643 results on '"S. Mack"'
Search Results
2. Identification of FIG-ROS1 fusion in tumor ID 749 from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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Herbert Haack, Xinmin Zhou, Matthew R. Silver, Jennifer S. Mack, Ting-Lei Gu, Meghan E. Kelly, Yerong Hu, Daiqiang Li, Katherine E. Crosby, and Victoria M. Rimkunas
- Abstract
(A) Schematic representation of the genomic region containing fig and ros1. Probes set 1 derived from ros1 (orange) and the deleted region (green). Probe set 2 derived from ros1 (orange) and fig (green). (B,C) Yellow arrows point to split signals indicative of balanced translocation in the HCC78 cell line and white arrows point to intact chromosome. (D,F) In both U-118 MG and tumor ID 749 only the ros1 (orange) probe anneals and the deleted region (green probe) does not. (E,G) ros1 (orange) and fig (green) probes overlap indicating fig-ros1 fusion. (H)
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- 2023
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3. Analysis of ALK and EGFR L858R expression in tumor ID 664 from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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Herbert Haack, Xinmin Zhou, Matthew R. Silver, Jennifer S. Mack, Ting-Lei Gu, Meghan E. Kelly, Yerong Hu, Daiqiang Li, Katherine E. Crosby, and Victoria M. Rimkunas
- Abstract
(A) A representative image of ALK break apart FISH (yellow arrows point to break apart). Images of ALK /L858R positive lung adenocarcinoma stained with (B) ALK D5F3, (C) total EGFR, (D) EGFR A746-E750del and (E) EGFR L858R antibodies.
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- 2023
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4. Supplementary Table 1 from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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Herbert Haack, Xinmin Zhou, Matthew R. Silver, Jennifer S. Mack, Ting-Lei Gu, Meghan E. Kelly, Yerong Hu, Daiqiang Li, Katherine E. Crosby, and Victoria M. Rimkunas
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XLSX file, 43KB, RT-PCR Results for FFPE ROS positive tumors.
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- 2023
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5. Data from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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Herbert Haack, Xinmin Zhou, Matthew R. Silver, Jennifer S. Mack, Ting-Lei Gu, Meghan E. Kelly, Yerong Hu, Daiqiang Li, Katherine E. Crosby, and Victoria M. Rimkunas
- Abstract
Purpose: To deepen our understanding of mutant ROS1 expression, localization, and frequency in non–small cell lung cancer (NSCLC), we developed a highly specific and sensitive immunohistochemistry (IHC)-based assay that is useful for the detection of wild-type and mutant ROS1.Experimental Design: We analyzed 556 tumors with the ROS1 D4D6 rabbit monoclonal antibody IHC assay to assess ROS1 expression levels and localization. A subset of tumors was analyzed by FISH to determine the percentage of these tumors harboring ROS1 translocations. Using specific and sensitive IHC assays, we analyzed the expression of anaplastic lymphoma kinase (ALK), EGFR L858R, and EGFR E746-A750del mutations in a subset of lung tumors, including those expressing ROS1.Results: In our NSCLC cohort of Chinese patients, we identified 9 (1.6%) tumors expressing ROS1 and 22 (4.0%) tumors expressing ALK. FISH identified tumors with ALK or ROS1 rearrangements, and IHC alone was capable of detecting all cases with ALK and ROS1 rearrangements. ROS1 fusion partners were determined by reverse transcriptase PCR identifying CD74-ROS1, SLC34A2-ROS1, and FIG-ROS1 fusions. Some of the ALK and ROS1 rearranged tumors may also harbor coexisting EGFR mutations.Conclusions: NSCLC tumors with ROS1 rearrangements are uncommon in the Chinese population and represent a distinct entity of carcinomas. The ROS1 IHC assay described here is a valuable tool for identifying patients expressing mutant ROS1 and could be routinely applied in clinical practice to detect lung cancers that may be responsive to targeted therapies. Clin Cancer Res; 18(16); 4449–57. ©2012 AACR.
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- 2023
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6. CCR Translation for This Article from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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Herbert Haack, Xinmin Zhou, Matthew R. Silver, Jennifer S. Mack, Ting-Lei Gu, Meghan E. Kelly, Yerong Hu, Daiqiang Li, Katherine E. Crosby, and Victoria M. Rimkunas
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CCR Translation for This Article from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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- 2023
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7. Supplementary Figure 2 from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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Herbert Haack, Xinmin Zhou, Matthew R. Silver, Jennifer S. Mack, Ting-Lei Gu, Meghan E. Kelly, Yerong Hu, Daiqiang Li, Katherine E. Crosby, and Victoria M. Rimkunas
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PDF file, 5111KB, (A) A representative image of ALK break apart FISH (yellow arrows point to break apart). Images of ALK /L858R positive lung adenocarcinoma stained with (B) ALK D5F3, (C) total EGFR, (D) EGFR A746-E750del and (E) EGFR L858R antibodies.
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- 2023
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8. RT-PCR Results for FFPE ROS positive tumors from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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Herbert Haack, Xinmin Zhou, Matthew R. Silver, Jennifer S. Mack, Ting-Lei Gu, Meghan E. Kelly, Yerong Hu, Daiqiang Li, Katherine E. Crosby, and Victoria M. Rimkunas
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Supplemental Table I RT-PCR Results for FFPE ROS1 positive tumors
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- 2023
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9. Supplementary Figure 1 from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion
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Herbert Haack, Xinmin Zhou, Matthew R. Silver, Jennifer S. Mack, Ting-Lei Gu, Meghan E. Kelly, Yerong Hu, Daiqiang Li, Katherine E. Crosby, and Victoria M. Rimkunas
- Abstract
PDF file, 3170KB, (A) Schematic representation of the genomic region containing fig and ros1. Probes set 1 derived from ros1 (orange) and the deleted region (green). Probe set 2 derived from ros1 (orange) and fig (green). (B,C) Yellow arrows point to split signals indicative of balanced translocation in the HCC78 cell line and white arrows point to intact chromosome. (D,F) In both U-118 MG and tumor ID 749 only the ros1 (orange) probe anneals and the deleted region (green probe) does not. (E,G) ros1 (orange) and fig (green) probes overlap indicating fig-ros1 fusion. (H)
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- 2023
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10. Drivers of survival of translocated tortoises
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Jeremy S. Mack and Kristin H. Berry
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Ecology ,General Earth and Planetary Sciences ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation ,General Environmental Science - Published
- 2023
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11. Adaptations of cognitive remediation therapy for adolescents with anorexia nervosa for delivery via telehealth
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Natalia C. Orloff, Kate McGinley, Katrina Lenz, Amy S. Mack, and C. Alix Timko
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Psychiatry and Mental health - Abstract
The COVID-19 pandemic hastened a transition to treatment delivery via telehealth. While barriers still exist, the increased uptake of telehealth has the potential to increase access to mental health treatment for all diagnoses, including eating disorders. Delivery of evidence-based treatment as well as adjunctive treatments, including those that are hard to find in-person, have been modified to virtual format to increase accessibility and allow for continuity of care for adolescents with anorexia nervosa.We describe how to modify and deliver Cognitive Remediation Therapy for youth with anorexia nervosa (CRT-AN) via a telehealth platform. Preliminary and practical guidance for best practice for both group and individual delivery is established.With minimal modifications, CRT-AN can be delivered via telehealth for both individual and group delivery. More disengagement in group delivery was noted; however, overall application of the treatment via a remote platform was observed.As more treatment moves to a telehealth format, highlighting how an adjunctive treatment like CRT-AN can combined with other treatments in a telehealth format has the potential to increase research in its implementation and furthermore increase its dissemination.Cognitive Remediation Therapy for Anorexia Nervosa (CRT-AN) requires significant manipulation of materials and supplementary human guidance. Suggestions for how to modify CRT-AN for remote delivery via telehealth are provided. Modifications grew out of immediate changes made during the beginning of the COVID-19 pandemic and can be used to inform changes therapists and programs can make to continue to or begin to use CRT-AN in a remote fashion.
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- 2022
12. Methodological Challenges for Epidemiologic Studies of Deprescribing at the End of Life
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Attah K Mbrah, Cara L. McDermott, Jennifer L. Lund, Seun Osundolire, Jennifer Tjia, Deborah S Mack, Yiyang Yuan, and Qiaoxi Chen
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medicine.medical_specialty ,Operationalization ,business.industry ,Outcome measurement ,Context (language use) ,Caregiver burden ,Article ,03 medical and health sciences ,0302 clinical medicine ,Harm ,Quality of life (healthcare) ,Deprescribing ,Medication appropriateness ,030220 oncology & carcinogenesis ,End of life ,Methods ,medicine ,Life expectancy ,General Earth and Planetary Sciences ,In patient ,Methodological ,030212 general & internal medicine ,Intensive care medicine ,business - Abstract
Purpose of Review To describe approaches to measuring deprescribing and associated outcomes in studies of patients approaching end of life (EOL). Recent Findings We reviewed studies published through 2020 that evaluated deprescribing in patients with limited life expectancy and approaching EOL. Deprescribing includes reducing the number of medications, decreasing medication dose(s), and eliminating potentially inappropriate medications. Tools such as STOPPFrail, OncPal, and the Unnecessary Drug Use Measure can facilitate deprescribing. Outcome measures vary and selection of measures should align with the operationalized deprescribing definition used by study investigators. Summary EOL deprescribing considerations include medication appropriateness in the context of patient goals for care, expected benefit from medication given life expectancy, and heightened potential for medication-related harm as death nears. Additional data are needed on how EOL deprescribing impacts patient quality of life, caregiver burden, and out-of-pocket medication-related costs to patients and caregivers. Investigators should design deprescribing studies with this information in mind.
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- 2021
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13. 8 Novel enhancement of multimodality treatment of prostate cancer, combining radiotherapy,vascular-targeted photodynamic therapy, and immunotherapy
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H.T. Sjoberg, S. Macklin, Y. Philippou, E.A. Murphy, I.D.C. Tullis, K.I. Jones, S.M. Stribbling, E.E. Parkes, E.F. Edmondson, D.A. Scheiblin, S.J. Lockett, D.A. Wink, J. Rittscher, D. Preise, L. Agemy, T. Yechezkel, A. Giaccia, I.G. Mills, R.J. Muschel, A. Vojnovic B.,Scherz, F.C. Hamdy, and R.J. Bryant
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Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2025
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14. Prevalence of Pain on Admission by Level of Cognitive Impairment in Nursing Homes
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Deborah S Mack, Kate L. Lapane, Shao-Hsien Liu, Reynolds A. Morrison, Bill M. Jesdale, Catherine Dubé, and Anthony P. Nunes
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Minimum Data Set ,medicine.medical_specialty ,business.industry ,Psychological intervention ,Cognition ,Pain management ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,030202 anesthesiology ,medicine ,Physical therapy ,Dementia ,Cognitive impairment ,Nursing homes ,business ,030217 neurology & neurosurgery - Abstract
Purpose To provide contemporary estimates of pain by level of cognitive impairment among US nursing home residents without cancer. Methods Newly admitted US nursing home residents without cancer assessed with the Minimum Data Set 3.0 at admission (2010-2016) were eligible (n=8,613,080). The Cognitive Function Scale was used to categorize level of cognitive impairment. Self-report or staff-assessed pain was used based on a 5-day look-back period. Estimates of adjusted prevalence ratios (aPR) were derived from modified Poisson models. Results Documented prevalence of pain decreased with increased levels of cognitive impairment in those who self-reported pain (68.9% no/mild, 32.9% severe) and those with staff-assessed pain (50.6% no/mild, 37.2% severe staff-assessed pain). Relative to residents with no/mild cognitive impairment, pharmacologic pain management was less prevalent in those with severe cognitive impairment (self-reported: 51.3% severe vs 76.9% in those with no/mild; staff assessed: 52.0% severe vs 67.7% no/mild). Conclusion Pain was less frequently documented in those with severe cognitive impairment relative to those with no/mild impairments. Failure to identify pain may result in untreated or undertreated pain. Interventions to improve evaluation of pain in nursing home residents with cognitive impairment are needed.
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- 2020
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15. Impact of nutrients on photoacclimation of phytoplankton in an oligotrophic lake measured with long-term and high-frequency data: implications for chlorophyll as an estimate of phytoplankton biomass
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Mark W. Buktenica, Jeremy S. Mack, and Scott F. Girdner
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0106 biological sciences ,Deep chlorophyll maximum ,010504 meteorology & atmospheric sciences ,Range (biology) ,010604 marine biology & hydrobiology ,Aquatic Science ,01 natural sciences ,chemistry.chemical_compound ,Oceanography ,Nutrient ,Water column ,chemistry ,Crater lake ,Chlorophyll ,Phytoplankton ,Environmental science ,Trophic state index ,0105 earth and related environmental sciences - Abstract
Chlorophyll measurements are commonly used to estimate phytoplankton biomass. However, phytoplankton readily acclimate to variations in light through a range of phenotypic responses, including major adjustments in chlorophyll pigmentation at the cellular level. The ratio of pigment chlorophyll to carbon concentration (Chl:C) is a commonly used metric in the oceanographic community to explore photoacclimation responses to varied light levels, yet is relatively rare in freshwater studies. Here we explore how nutrient variability impacted summertime Chl:C ratios of a natural phytoplankton community throughout the water column of a stratified oligotrophic lake. We utilized both long-term (18–24 years) and high-frequency (daily) data from Crater Lake, Oregon, a deep mountain lake with little anthropogenic disturbance. As expected, fluctuation in nutrients had a strong impact on phytoplankton particle density, primary productivity, light penetration, and water clarity. However, chlorophyll concentration did not register predictable changes even though the vertical location of the deep chlorophyll maximum was responsive to the overlying algal density. The impact of elevated nutrients on the Chl:C ratio was further complicated by upward shifts in chlorophyll distribution. The muted response of chlorophyll concentration to nutrients may be partially explained by variations in phytoplankton community composition or iron stress.
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- 2020
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16. Prevalent Statin Use in Long‐Stay Nursing Home Residents with Life‐Limiting Illness
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Kate L. Lapane, Anne L. Hume, Jennifer Tjia, and Deborah S Mack
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Male ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Population ,Ethnic group ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,medicine ,Homes for the Aged ,Humans ,Medicare Part D ,030212 general & internal medicine ,Medical prescription ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Palliative Care ,Statin treatment ,Drug Utilization ,United States ,Nursing Homes ,Cross-Sectional Studies ,Chronic Disease ,Emergency medicine ,Polypharmacy ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Geriatrics and Gerontology ,Nursing homes ,business - Abstract
To evaluate the prevalence and factors associated with statin pharmacotherapy in long-stay nursing home residents with life-limiting illness.Cross-sectional.US Medicare- and Medicaid-certified nursing home facilities.Long-stay nursing home resident Medicare fee-for-service beneficiaries aged 65 years or older with life-limiting illness (n = 424 212).Prevalent statin use was estimated as any low-moderate intensity (daily dose low-density lipoprotein-cholesterol [LDL-C] reduction30%-50%) and high-intensity (daily dose LDL-C reduction50%) use via Medicare Part D claims for a prescription supply on September 30, 2016, with a 90-day look-back period. Life-limiting illness was operationally defined to capture those near the end of life using evidence-based criteria to identify progressive terminal conditions or limited prognoses (6 mo). Poisson models provided estimates of adjusted prevalence ratios and 95% confidence intervals for resident factors.A total of 34% of residents with life-limiting illness were prescribed statins (65-75 y = 44.0%, high intensity = 11.1%;75 y = 31.1%, high intensity = 5.4%). Prevalence of statins varied by life-limiting illness definition. Of those with a prognosis of less than 6 months, 23% of the 65 to 75 and 12% of the older than 75 age groups were on statins. Factors positively associated with statin use included minority race or ethnicity, use of more than five concurrent medications, and atherosclerotic cardiovascular disease or risk factors.Despite having a life-limiting illness, more than one-third of clinically compromised long-stay nursing home residents remain on statins. Although recent national guidelines have expanded indications for statins, the benefit of continued therapy in an advanced age population near the end of life is questionable. Efforts to deprescribe statins in the nursing home setting may be warranted. J Am Geriatr Soc 68:708-716, 2020.
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- 2020
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17. When Political Parties Die: A Cross-National Analysis of Disalignment and Realignment
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Charles S. Mack
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- 2010
18. Screening Mammography Among Older Women: A Review of United States Guidelines and Potential Harms
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Kate L. Lapane and Deborah S Mack
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medicine.medical_specialty ,Special populations ,Breast Neoplasms ,Medical Overuse ,03 medical and health sciences ,Health services ,Life Expectancy ,0302 clinical medicine ,Breast cancer ,medicine ,Humans ,Mass Screening ,Mammography ,030212 general & internal medicine ,Limited evidence ,Early Detection of Cancer ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Screening mammography ,Age Factors ,Original Articles ,General Medicine ,medicine.disease ,United States ,030220 oncology & carcinogenesis ,Family medicine ,Practice Guidelines as Topic ,Female ,Observational study ,business ,Nursing homes - Abstract
In the United States, older women (aged ≥65 years) continue to receive routine screening mammography surveillance, despite limited evidence supporting the benefits to this subpopulation. This article reviews screening mammography guidelines and the potential harms of such screening for older women in the United States. Published guidelines and recommendations on screening mammography for older women from professional medical societies and organizations in the United States were reviewed from the mid-20th century to present. Observational data were then synthesized to present the documented harms from screening mammography among older women. In 1976, the American Cancer Society recommended to screen all women aged ≥40 years with no upper age limit. With time, other major U.S. medical societies adopted their own screening guidelines without a consensus on age of screening cessation. A population-wide screening effort has largely continued without an upper age limit and with it, a growing body of literature on the harms of screening older women. Reported harms from screening mammography procedures have included physical pain, psychological distress, excessive use of health services from overdiagnoses/false positives, and undue financial expenses. These costs are particularly pronounced among special populations with limited life expectancies such as those of very advanced age ≥80 years, long-term nursing home residents, and the cognitively impaired. When potential harms, remaining life years, and the viability of available treatments are considered, the burdens of screening mammography often outweigh the benefits for older women. For some cases, an individualized approach to recommendations would be appropriate. National guidelines should be updated to provide clear guidance for screening women of advanced age, especially those in special populations with limited life expectancies.
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- 2019
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19. Racial Segregation Across U.S. Nursing Homes: A Systematic Review of Measurement and Outcomes
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Deborah S Mack, Christine M. Ulbricht, Kate L. Lapane, Pryce Michener, Bill M. Jesdale, and Sarah Forrester
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Gerontology ,Research design ,Ethnic group ,Scopus ,Black People ,White People ,03 medical and health sciences ,Generalized entropy index ,0302 clinical medicine ,Humans ,030212 general & internal medicine ,Healthcare Disparities ,Review Articles ,Aged ,Quality of Health Care ,Minimum Data Set ,Social Segregation ,Gini coefficient ,030503 health policy & services ,General Medicine ,United States ,Nursing Homes ,Index of dissimilarity ,Long-term care ,Geriatrics and Gerontology ,0305 other medical science ,Psychology - Abstract
Background and Objectives Nursing homes remain subjected to institutional racial segregation in the United States. However, a standardized approach to measure segregation in nursing homes does not appear to be established. A systematic review was conducted to identify all formal measurement approaches to evaluate racial segregation among nursing home facilities, and to then identify the association between segregation and quality of care in this context. Research Design and Methods PubMed, Scopus, and Web of Science databases were searched (January 2018) for publications relating to nursing home segregation. Following the PRISMA guidelines, studies were included that formally measured racial segregation of nursing homes residents across facilities with regional-level data. Results Eight studies met the inclusion criteria. Formal segregation measures included the Dissimilarity Index, Disparities Quality Index, Modified Thiel’s Entropy Index, Gini coefficient, and adapted models. The most common data sources were the Minimum Data Set (MDS; resident-level), the Certification and Survey Provider Enhanced Reporting data (CASPER; facility-level), and the Area Resource File/ U.S. Census Data (regional-level). Most studies showed evidence of racial segregation among U.S. nursing home facilities and documented a negative impact of segregation on racial minorities and facility-level quality outcomes. Discussion and Implications The measurement of racial segregation among nursing homes is heterogeneous. While there are limitations to each methodology, this review can be used as a reference when trying to determine the best approach to measure racial segregation in future studies. Moreover, racial segregation among nursing homes remains a problem and should be further evaluated.
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- 2019
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20. Work-in-Progress-Watershed Explorers: Designing a Virtual Reality Game to Promote Local Watershed Literacy
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Thomas Hammond, Kate Semmens, David J. Anastasio, Chad Schwartz, Robson Araujo-Junior, Jason Slipp, Alec M. Bodzin, Jeremy S. Mack, Daphne Mayer, Robert Neitz, and Beigie Lam
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Watershed ,business.industry ,Situated learning ,media_common.quotation_subject ,ComputingMilieux_PERSONALCOMPUTING ,Usability ,Virtual reality ,Literacy ,Local community ,Multidisciplinary approach ,Mathematics education ,business ,Curriculum ,media_common - Abstract
This work-in-progress paper overviews the development of a multidisciplinary place-based virtual reality learning game to increase learners' watershed literacy by playing guided exploration of the Lehigh River watershed's historical and environmental issues. This desktop VR game aligns to the National Geography Standards to support schools' adopted curricula. Its design is informed by digital game-based and situated learning theories focusing on place-based and gaming features that support learning. “Watershed Explorers” may assist learners' emotional connection to their region through authentic and relevant learning experiences that might inspire them to support their local community welfare. The usability studies with the prototype version showed that players were engaged, felt immersed, and experienced a sense of presence. The game storyline is presented.
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- 2021
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21. Geographic Variation of Statin Use Among US Nursing Home Residents With Life-limiting Illness
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Deborah S Mack, Kate L. Lapane, Jennifer Tjia, and Jonggyu Baek
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Research design ,Male ,Palliative care ,Referral ,Clinical Decision-Making ,Medicare ,Drug Prescriptions ,Article ,03 medical and health sciences ,0302 clinical medicine ,Health care ,Medicare Part D ,Medicine ,Humans ,030212 general & internal medicine ,Geography, Medical ,Practice Patterns, Physicians' ,Aged ,Aged, 80 and over ,Minimum Data Set ,business.industry ,030503 health policy & services ,Public Health, Environmental and Occupational Health ,Age Factors ,Odds ratio ,Patient Acceptance of Health Care ,United States ,Nursing Homes ,Long-term care ,Cross-Sectional Studies ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,0305 other medical science ,business ,Demography - Abstract
BACKGROUND Medically compromised nursing home residents continue to be prescribed statins, despite questionable benefits. OBJECTIVE To describe regional variation in statin use among residents with life-limiting illness. RESEARCH DESIGN Cross-sectional study using 2016 Minimum Data Set 3.0 assessments linked to Medicare administrative data and health service utilization area resource files. SETTING Nursing homes (n=14,147) within hospital referral regions (n=306) across the United States. SUBJECTS Long-stay residents (aged 65 y and older) with life-limiting illness (eg, serious illness, palliative care, or prognosis
- Published
- 2021
22. National Trends in Statin Use among the United States Nursing Home Population (2011-2016)
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Kate L. Lapane, Anne L. Hume, Jennifer Tjia, and Deborah S Mack
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Statin ,medicine.drug_class ,Guidelines as Topic ,Medicare ,Article ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,Medicare Part D ,Medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Aged ,Skilled Nursing Facilities ,Minimum Data Set ,business.industry ,Guideline ,Statin treatment ,Confidence interval ,Drug Utilization ,United States ,Nursing Homes ,Cross-Sectional Studies ,Geriatrics and Gerontology ,Deprescribing ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,030217 neurology & neurosurgery ,Demography - Abstract
BACKGROUND: Little is known about trends in statin use in United States (US) nursing homes. OBJECTIVES: To describe national trends in statin use in nursing homes and evaluate the impact of the introduction of generic statins, safety warnings, and guideline recommendations on statin use. METHODS: This study employed a repeated cross-sectional prevalence design to evaluate monthly statin use in long-stay US nursing home residents enrolled in Medicare fee-for-service using the Minimum Data Set 3.0 and Medicare Part D claims between April 2011– December 2016. Stratified by age in years (65–75, ≥76), analyses estimated trends and level changes with 95% confidence intervals (CI) following statin-related events (the availability of generic statins, American Heart Association/American College of Cardiology guideline updates, and US Food and Drug Administration safety warnings) through segmented regression models corrected for autocorrelation. RESULTS: Statin use increased from April 2011 to December 2016 (65–75 years: 38.6% to 43.3%; ≥76 years: 26.5% to 30.0%), as did high intensity statin use (65–75 years: 4.8% to 9.5%; ≥76 years: 2.3% to 4.5%). The introduction of generic statins yielded little impact on prevalence of statins in nursing home residents. Positive trend changes in high intensity statin use occurred following national guideline updates in December 2011 (65 to 75 years: β = 0.16; 95% CI: 0.09 to 0.22; ≥76 years: β = 0.09; 95% CI: 0.06 to 0.12) and November 2013 (65 to 75 years: β = 0.11; 95% CI: 0.09 to 0.13; ≥76 years: β = 0.04; 95% CI: 0.03 to 0.05). There were negative trend changes for any statin use concurrent with FDA statin safety warnings in March 2012 among both age groups (65–75 years: β trend change=−0.06; 95% CI: −0.10 to −0.02; ≥76 years: β trend change= −0.05; 95% CI: −0.08 to −0.01). The publication of a statin deprescribing trial results yielded a decrease in any statin use among the ≥76 years age group (β level change= −0.25, 95% CI: −0.48 to −0.09; β trend change= −0.03, 95% CI: −0.04 to −0.01) with both age groups observing a positive trend change with high intensity statins (65 to 75 year age group: β = 0.11; 95% CI: 0.02 to 0.21; ≥76 years age group: β = 0.05; 95% CI: 0.01 to 0.09). CONCLUSION: Overall, statin use in US nursing homes increased from 2011 to 2016. Guidelines and statin-related events appeared to impact use in the nursing home setting. As such, statin guidelines and messaging should provide special consideration for nursing home populations, who may have more risk than benefit from statin pharmacotherapy.
- Published
- 2021
23. Business Strategy for an Era of Political Change
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Charles S. Mack
- Published
- 2001
24. Statin Discontinuation and Life-Limiting Illness in Non-Skilled Stay Nursing Homes at Admission
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Kate L. Lapane, Jennifer Tjia, Deborah S Mack, and Jonggyu Baek
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Male ,medicine.medical_specialty ,Palliative care ,030204 cardiovascular system & hematology ,Medicare ,Severity of Illness Index ,Article ,03 medical and health sciences ,0302 clinical medicine ,Deprescriptions ,Medicine ,Medicare Part D ,Humans ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Aged, 80 and over ,Minimum Data Set ,business.industry ,Palliative Care ,Retrospective cohort study ,Fee-for-Service Plans ,United States ,Discontinuation ,Nursing Homes ,Long-term care ,Relative risk ,Emergency medicine ,Female ,Geriatrics and Gerontology ,Deprescribing ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business - Abstract
OBJECTIVES To estimate 30-day statin discontinuation among newly admitted nursing home residents overall and within categories of life-limiting illness. DESIGN Retrospective cohort using Minimum Data Set 3.0 nursing home admission assessments from 2015 to 2016 merged to Medicare administrative data files. SETTING U.S. Medicare- and Medicaid-certified nursing home facilities (n = 13,092). PARTICIPANTS Medicare fee-for-service beneficiaries, aged 65 years and older, newly admitted to nursing homes for non-skilled nursing facility stays on statin pharmacotherapy at the time of admission (n = 73,247). MEASUREMENTS Residents were categorized using evidence-based criteria to identify progressive, terminal conditions or limited prognoses (
- Published
- 2020
25. Crowding Affects Health, Growth, and Behavior in Headstart Pens for Agassiz's Desert Tortoise
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Heather E. Schneider, Kristin H. Berry, and Jeremy S. Mack
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0106 biological sciences ,Desert (philosophy) ,Tortoise ,010604 marine biology & hydrobiology ,Endangered species ,Biology ,010603 evolutionary biology ,01 natural sciences ,Crowding ,Spinal column ,Condition index ,Threatened species ,Juvenile ,Animal Science and Zoology ,Ecology, Evolution, Behavior and Systematics ,Demography - Abstract
Worldwide, scientists have headstarted threatened and endangered reptiles to augment depleted populations. Not all efforts have been successful. For the threatened Agassiz's desert tortoise (Gopherus agassizii), one challenge to recovery is poor recruitment of juveniles into adult populations, and this is being addressed through headstart programs. We evaluated 8 cohorts of juvenile desert tortoises from 1 to 8 yrs old in a headstart program at Edwards Air Force Base, California, for health, behavior, and growth. We also examined capacities of the headstart pens. Of 148 juveniles evaluated for health, 99.3% were below a prime condition index; 14.9% were lethargic and unresponsive; 59.5% had protruding spinal columns and associated concave scutes; 29.1% had evidence of ant bites; and 14.2% had moderate to severe injuries to limbs or shell. Lifetime growth rates for juveniles 1–8 yrs of age were approximately two times less than growth rates reported for wild populations. Tortoises in older cohorts...
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- 2018
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26. Non-Hispanic Black-White disparities in pain and pain management among newly admitted nursing home residents with cancer
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Deborah S Mack, Jacob N. Hunnicutt, Kate L. Lapane, and Bill M. Jesdale
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medicine.medical_specialty ,Minimum Data Set ,business.industry ,Cancer ,nursing homes ,Pain management ,medicine.disease ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,pain management ,Pro re nata ,Family medicine ,Health care ,medicine ,cancer ,pain ,030212 general & internal medicine ,Journal of Pain Research ,business ,Nursing homes ,race ,030217 neurology & neurosurgery ,Original Research - Abstract
Deborah S Mack,1 Jacob N Hunnicutt,1 Bill M Jesdale,2 Kate L Lapane2 1Department of Quantitative Health Sciences, Clinical and Population Health Research Program, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA, USA; 2Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA Background: Racial disparities in pain management persist across health care settings and likely extend into nursing homes. No recent studies have evaluated racial disparities in pain management among residents with cancer in nursing homes at time of admission.Methods: Using a cross-sectional study design, we compared reported pain and pain management between non-Hispanic White and non-Hispanic Black newly admitted nursing home residents with cancer (n=342,920) using the de-identified Minimum Data Set version 3.0. Pain management strategies included the use of scheduled analgesics, pro re nata analgesics, and non-pharmacological methods. Presence of pain was based on self-report when residents were able, and staff report when unable. Robust Poisson models provided estimates of adjusted prevalence ratios (aPR) and 95% CIs for reported pain and pain management strategies.Results: Among nursing home residents with cancer, ~60% reported pain with non-Hispanic Blacks less likely to have both self-reported pain (aPR [Black versus White]: 0.98, 95% CI: 0.97–0.99) and staff-reported pain (aPR: 0.89, 95% CI: 0.86–0.93) documentation compared with Non-Hispanic Whites. While most residents received some pharmacologic pain management, Blacks were less likely to receive any compared with Whites (Blacks: 66.6%, Whites: 71.1%; aPR: 0.98, 95% CI: 0.97–0.99), consistent with differences in receipt of non-pharmacologic treatments (Blacks: 25.8%, Whites: 34.0%; aPR: 0.98, 95 CI%: 0.96–0.99).Conclusion: Less pain was reported for Black compared with White nursing home residents and White residents subsequently received more frequent pain management at admission. The extent to which unequal reporting and management of pain persists in nursing homes should be further explored. Keywords: nursing homes, cancer, pain, pain management, race 
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- 2018
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27. Developments and results in the context of the JEM-EUSO program obtained with the ESAF simulation and analysis framework
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S. Abe, J. H. Adams, D. Allard, P. Alldredge, L. Anchordoqui, A. Anzalone, E. Arnone, B. Baret, D. Barghini, M. Battisti, J. Bayer, R. Bellotti, A. A. Belov, M. Bertaina, P. F. Bertone, M. Bianciotto, P. L. Biermann, F. Bisconti, C. Blaksley, S. Blin-Bondil, P. Bobik, K. Bolmgren, S. Briz, J. Burton, F. Cafagna, G. Cambié, D. Campana, F. Capel, R. Caruso, M. Casolino, C. Cassardo, A. Castellina, K. Černý, M. J. Christl, R. Colalillo, L. Conti, G. Cotto, H. J. Crawford, R. Cremonini, A. Creusot, A. Cummings, A. de Castro Gónzalez, C. de la Taille, L. del Peral, R. Diesing, P. Dinaucourt, A. Di Nola, A. Ebersoldt, T. Ebisuzaki, J. Eser, F. Fenu, S. Ferrarese, G. Filippatos, W. W. Finch, F. Flaminio, C. Fornaro, D. Fuehne, C. Fuglesang, M. Fukushima, D. Gardiol, G. K. Garipov, A. Golzio, P. Gorodetzky, F. Guarino, C. Guépin, A. Guzmán, A. Haungs, T. Heibges, J. Hernández-Carretero, F. Isgrò, E. G. Judd, F. Kajino, I. Kaneko, Y. Kawasaki, M. Kleifges, P. A. Klimov, I. Kreykenbohm, J. F. Krizmanic, V. Kungel, E. Kuznetsov, F. López Martínez, S. Mackovjak, D. Mandát, M. Manfrin, A. Marcelli, L. Marcelli, W. Marszał, J. N. Matthews, A. Menshikov, T. Mernik, M. Mese, S. S. Meyer, J. Mimouni, H. Miyamoto, Y. Mizumoto, A. Monaco, J.A Morales de los Ríos, S. Nagataki, J. M. Nachtman, D. Naumov, A. Neronov, T. Nonaka, T. Ogawa, S. Ogio, H. Ohmori, A. V. Olinto, Y. Onel, G. Osteria, A. Pagliaro, B. Panico, E. Parizot, I. H. Park, B. Pastircak, T. Paul, M. Pech, F. Perfetto, P. Picozza, L. W. Piotrowski, Z. Plebaniak, J. Posligua, R. Prevete, G. Prévôt, H. Prieto, M. Przybylak, M. Putis, E. Reali, P. Reardon, M. H. Reno, M. Ricci, M. Rodríguez Frías, G. Romoli, G. Sáez Cano, H. Sagawa, N. Sakaki, A. Santangelo, O. A. Saprykin, F. Sarazin, M. Sato, H. Schieler, P. Schovánek, V. Scotti, S. Selmane, S. A. Sharakin, K. Shinozaki, J. F. Soriano, J. Szabelski, N. Tajima, T. Tajima, Y. Takahashi, M. Takeda, Y. Takizawa, C. Tenzer, S. B. Thomas, L. G. Tkachev, T. Tomida, S. Toscano, M. Traïche, D. Trofimov, K. Tsuno, P. Vallania, L. Valore, T. M. Venters, C. Vigorito, P. von Ballmoos, M. Vrabel, S. Wada, J. Watts, A. Weindl, L. Wiencke, J. Wilms, D. Winn, H. Wistrand, I. V. Yashin, R. Young, and M. Yu. Zotov
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract JEM-EUSO is an international program for the development of space-based Ultra-High Energy Cosmic Ray observatories. The program consists of a series of missions which are either under development or in the data analysis phase. All instruments are based on a wide-field-of-view telescope, which operates in the near-UV range, designed to detect the fluorescence light emitted by extensive air showers in the atmosphere. We describe the simulation software ESAF in the framework of the JEM-EUSO program and explain the physical assumptions used. We present here the implementation of the JEM-EUSO, POEMMA, K-EUSO, TUS, Mini-EUSO, EUSO-SPB1 and EUSO-TA configurations in ESAF. For the first time ESAF simulation outputs are compared with experimental data.
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- 2023
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28. The Executive's Handbook of Trade and Business Associations: How They Work--And How to Make Them Work Effectively for You
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Charles S. Mack
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- 1990
29. Replacement of a unique population of newts (Taricha granulosa mazamae) by introduced signal crayfish (Pacifastacus leniusculus) in Crater Lake, Oregon
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Jeremy S. Mack, Andrew M. Ray, Mark W. Buktenica, David K. Hering, John Umek, and Scott F. Girdner
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0106 biological sciences ,education.field_of_study ,Ecology ,biology ,010604 marine biology & hydrobiology ,Rough-skinned newt ,Population ,biology.organism_classification ,Crayfish ,010603 evolutionary biology ,01 natural sciences ,Signal crayfish ,Pacifastacus ,biology.animal ,Crater lake ,Taricha ,Salamander ,education ,Ecology, Evolution, Behavior and Systematics - Abstract
The signal crayfish (Pacifastacus leniusculus) was introduced to Crater Lake in 1915 and now threatens the local extinction of an endemic salamander, the Mazama newt (Taricha granulosa mazamae). More than a century after their introduction, crayfish have expanded in distribution to occupy nearly 80% of the lakeshore. Although newts remain in uninvaded areas, they are almost entirely absent in crayfish occupied areas. Abundance of benthic macroinvertebrates was dramatically reduced in locations with crayfish compared with areas of the lake where crayfish were absent. Isotopic signatures of newt and crayfish tissue confirm overlap in the diets of the two species and demonstrate their similar position in the Crater Lake food web. Mesocosm experiments conducted with newts and crayfish revealed that crayfish prey directly on newts, displace newts from cover, and generally alter newt behavior. Combined, this evidence suggests that further crayfish expansion likely will cause additional declines in newt abundance and distribution, and could lead to extinction of the unique population of newts in Crater Lake.
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- 2017
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30. Is There a Role for Internal Medicine Residency Preparation Courses in the Fourth Year Curriculum? A Single-Center Experience
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Lauren A. Heidemann, Mark S Kolbe, Eric Walford, Jacob S. Mack, and Helen Morgan
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Medical education ,020205 medical informatics ,business.industry ,MEDLINE ,Internship and Residency ,Pilot Projects ,02 engineering and technology ,Single Center ,Undergraduate methods ,03 medical and health sciences ,0302 clinical medicine ,0202 electrical engineering, electronic engineering, information engineering ,Internal Medicine ,Humans ,Medicine ,Clinical Competence ,Curriculum ,030212 general & internal medicine ,Clinical competence ,business ,Concise Research Reports ,Education, Medical, Undergraduate - Published
- 2018
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31. Improving Advanced Care Planning through Physician Orders for Life-Sustaining Treatment (POLST) Expansion across the United States: Lessons Learned from State-Based Developments
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David Dosa and Deborah S Mack
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Advance care planning ,Palliative care ,Inservice Training ,Attitude of Health Personnel ,media_common.quotation_subject ,Interviews as Topic ,03 medical and health sciences ,Advance Care Planning ,0302 clinical medicine ,Nursing ,State (polity) ,Life sustaining treatment ,030502 gerontology ,Medicine ,Humans ,Longitudinal Studies ,Prospective Studies ,media_common ,Terminal Care ,business.industry ,General Medicine ,United States ,Life Support Care ,030220 oncology & carcinogenesis ,0305 other medical science ,business - Abstract
Background: The Physician Orders for Life-Sustaining Treatment (POLST) Paradigm is an effective advance care planning tool. However, barriers to implementation persist. In the United States, POLST program development occurs at the state-level. Substantial differences between states has left POLST implementation largely unstandardized. No peer-reviewed studies to date have evaluated state-based POLST program development over time. Objective: To assess and learn from the successes and barriers in state-based POLST program development over time to improve the reach of POLST or similar programs across the United States. Design: An exploratory, prospective cohort study that utilized semistructured telephone interviews was conducted over a 3-year period (2012-2015). Stakeholder representatives from state POLST coalitions (n = 14) were repeatedly queried on time-relevant successes, barriers, and innovations during POLST program development with levels of legislative and medical barriers rated 1 to 10. Interviews were transcribed and analyzed using techniques grounded in qualitative theory. Results: All coalition representatives reported continuous POLST expansion with improved outreach and community partnerships. Significant barriers to expansion included difficulty in securing funding for training and infrastructure, lack of statewide metric systems to adequately assess expansion, lack of provider support, and legislative concerns. Medical barriers (mean [standard deviation]: 5.0 [0.2]) were rated higher than legislative (3.0 [0.6]; P < .001). Conclusion: POLST programs continue to grow, but not without barriers. Based on the experiences of developing coalitions, we were able to identify strategies to expand POLST programs and overcome barriers. Ultimately the “lessons learned” in this study can serve as a guide to improve the reach of POLST or similar programs.
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- 2019
32. Formal Recognition as a Means of Advancing Deutschlandpolitik
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Kathryn S. Mack
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- 2019
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33. P.448 BI 1358894 attenuates cholecystokinin tetrapeptide (CCK-4) induced anxiety and panic symptoms in healthy male volunteers
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M. Goettel, S. Mack, S. Just, V. Sharma, R. Fuertig, and J.A. den Boer
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Pharmacology ,medicine.medical_specialty ,Tetrapeptide ,business.industry ,Panic symptoms ,Psychiatry and Mental health ,Endocrinology ,Neurology ,Internal medicine ,medicine ,CCK-4 ,Anxiety ,Pharmacology (medical) ,Neurology (clinical) ,medicine.symptom ,business ,Biological Psychiatry ,Cholecystokinin ,medicine.drug - Published
- 2020
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34. 15 Years of the MOVE! Weight Management Program
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D. Longerbone, P. Dadyar, C. Richie, M. Coffelt, S. Raffa, S. Mack, G. Eichenlaub, S. Richards, C. Robson, H. Stanley-Sutton, E. Arra, and H. Schumacker
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Nutrition and Dietetics ,business.industry ,Weight management ,Medicine ,Operations management ,General Medicine ,business ,Food Science - Published
- 2020
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35. Cancer Pain in Relation to Metropolitan Area Segregation and Nursing Home Racial and Ethnic Composition
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Deborah S Mack, Kate L. Lapane, Sarah Forrester, and Bill M. Jesdale
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Ethnic group ,Article ,White People ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Humans ,Medicine ,030212 general & internal medicine ,General Nursing ,Minimum Data Set ,business.industry ,Health Policy ,Ethnic composition ,Cancer Pain ,Hispanic or Latino ,General Medicine ,Pain management ,Metropolitan area ,United States ,Confidence interval ,Nursing Homes ,Cross-Sectional Studies ,Geriatrics and Gerontology ,business ,Nursing homes ,Cancer pain ,030217 neurology & neurosurgery ,Demography - Abstract
Objectives To estimate pain reporting among residents with cancer in relation to metropolitan area segregation and NH racial and ethnic composition. Design Cross-sectional study. Setting and Participants 383,757 newly admitted black (B), Hispanic (H), or white (W) residents with cancer in 12,096 US NHs (2011-2013). Methods Using the Minimum Data Set 3.0, pain in past 5 days was determined by self-report or use of pain management. The Theil entropy index, a measure of metropolitan area segregation, was categorized [high (up to 0.20), very high (0.20-0.30), or extreme (0.30-0.53)]. Results Pain prevalence decreased across segregation level (black: high = 77%, very high = 75%, extreme = 72%; Hispanic: high = 79%, very high = 77%, extreme = 70%; white: high = 80%, very high = 77%, extreme = 74%). In extremely segregated areas, all residents were less likely to have recorded pain [adjusted prevalence ratios: blacks, 4.6% less likely, 95% confidence interval (CI) 3.1%-6.1%; Hispanics, 6.9% less likely, 95% CI 4.2%-9.6%; whites, 7.4% less likely, 95% CI 6.5%-8.2%] than in the least segregated areas. At all segregation levels, pain was recorded more frequently for residents (black or white) in predominantly white (>80%) NHs than in mostly black (>50%) NHs or residents (Hispanic or white) in predominantly white NHs than mostly Hispanic (>50%) NHs. Conclusions and Implications We observed decreased pain recording in metropolitan areas with greater racial and ethnic segregation. This may occur through the inequitable distribution of resources between NHs, resident-provider empathy, provider implicit bias, resident trust, and other factors.
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- 2020
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36. Biomarkers for predicting cancer in women with a suspicious mammogram
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Jennifer May, Richard A. Hoefer, Alessandra Luchini, Virginia Espina, Ngoc Vuong, Lance A. Liotta, Maxwell L. Smith, Denitra S Mack, and Claudius Mueller
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Oncology ,Biomarker identification ,Cancer Research ,medicine.medical_specialty ,business.industry ,Cancer ,Surgical procedures ,medicine.disease ,Internal medicine ,Healthy control ,medicine ,business ,Early breast cancer - Abstract
e15533 Background: Biomarker identification for early breast cancer diagnosis is confounded by comparing healthy control patients to patients undergoing surgical procedures and stress of a potential cancer diagnosis. We implemented a clinical research protocol that combines biomarker harvesting and identification with Breast Imaging-Reporting and Data System (BIRADS) results, within a cohort of women with a suspicious mammogram who donated samples prior to biopsy. The primary goals were to discover candidate novel plasma markers for stage I breast cancer versus benign lesions, and validate the markers by mass spectrometry and immunohistochemistry. Methods: 150 women found on screening mammography to have a BIRADS IV or V mammographic abnormality were enrolled in the IRB approved study, with one year follow-up. After informed consent, serum, plasma, and saliva specimens were obtained and frozen. The patient underwent image guided biopsy of the mammographic abnormality. Hydrogel nanoparticles were used to harvest and concentrate low abundance protein biomarkers from plasma. Proteins were identified by mass spectrometry. The BIRADS score and biopsy outcome were blinded to the laboratory researchers. Results: 37/150 women (median age 64, 73% ER+, 70% PR+) were diagnosed with biopsy-proven breast cancer. 15/37 had a family history of breast cancer. Within the context of stress of an abnormal mammogram and invasive biopsy, we identified 5478 plasma peptides. A model to predict endpoints that discriminate cancer vs no cancer was developed using cross-validation and lasso shrinkage method. The best fit multi-analyte ROC/AUC model of peptide spectral matches revealed 10 candidate peptides, including PLAA, TRAPPC9, PROS1, DDX41, ANKRD63, EGFLAM (AUC = 0.81), that discriminated cancer versus no cancer. The functional mechanisms of these proteins are calcium metabolism, GPI anchor biosynthesis, neural-immune crosstalk, DNA repair, and ubiquitin-mediated protein trafficking. Conclusions: Molecular profiling of blood can potentially complement imaging to improve diagnostic specificity in the setting of a suspicious mammogram. This unique trial design, enhanced by nanotechnology protein harvesting, identified potential novel cancer biomarkers in the presence of a suspicious mammogram. A confirmation trial is underway.
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- 2020
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37. An Uncertain Future for a Population of Desert Tortoises Experiencing Human Impacts
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Julie L. Yee, Lisa L. Lyren, Jeremy S. Mack, and Kristin H. Berry
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0106 biological sciences ,education.field_of_study ,Desert (philosophy) ,Ecology ,Population ,Global warming ,010607 zoology ,010603 evolutionary biology ,01 natural sciences ,Geography ,Threatened species ,Animal Science and Zoology ,education ,Ecology, Evolution, Behavior and Systematics - Abstract
We evaluated the status of a population of Mojave Desert Tortoises (Gopherus agassizii), a threatened species, in the El Paso Mountains of the northwestern Mojave Desert in California, USA...
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- 2020
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38. Targeted Molecular Therapy in Palliative Cancer Management
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H, Staats, primary, C, Cassidy, additional, J, Kelso, additional, S, Mack, additional, S, Morand, additional, K, Choucair, additional, H, Qaqish, additional, O, Willis, additional, D, Craig, additional, J, Duff, additional, L, Stanbery, additional, G, Edelman, additional, L, Dworkin, additional, and J, Nemunaitis, additional
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- 2020
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39. Some Aspects of Male Infertility
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William S, Mack
- Published
- 2018
40. Renal Tuberculosis and Excretory Bacilluria
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William S, Mack
- Published
- 2018
41. LESS IS MORE: POTENTIAL OVERSCREENING FOR BREAST CANCER IN U.S. NURSING HOMES
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Deborah S Mack, Mara M. Epstein, Kate L. Lapane, Catherine Dubé, and Robin E. Clark
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medicine.medical_specialty ,Abstracts ,Health (social science) ,Overscreening ,Breast cancer ,business.industry ,Family medicine ,Medicine ,Life-span and Life-course Studies ,business ,Nursing homes ,medicine.disease ,Health Professions (miscellaneous) - Abstract
US guidelines regarding when to stop routine breast cancer surveillance with mammography screening remain unclear. Consequently, it is unclear if a long-term care population receives this service. The objectives of this cross-sectional study were to estimate the extent to which mammography screening occurs among US long-term care nursing home residents, and to identify resident- and regional- level factors associated with its use including geographic variation. The study sample included women aged ≥65 years residing in nursing homes for at least one year, with an annual Minimum Data Set (MDS) 3.0 assessment, continuous Medicare Part B enrollment, and no strong clinical indication for mammography screening (n=389,821). Using 2011 Physician/Supplier Part B claims, we estimated the prevalence of mammography screening stratified by guideline age classification (65–74, ≥75 years). Associations between mammography screening and independent predictor variables were estimated by crude and adjusted prevalence ratios from robust Poisson regression models accounting for the clustering of residents within nursing homes. Mammography screening among long-term nursing home residents occurs, despite being an older population that is mostly disabled (77.9%) and cognitively impaired (76.3%) with an average life expectancy 75 years (95% CI: 1.7% - 1.8%), with geographic variation observed. Older age, cognitive impairment, frailty, and hospice were inversely associated with screening. Thoughtful consideration about individual screening recommendations and the implementation of more specific guidelines is warranted to prevent overscreening.
- Published
- 2018
42. Bidirectional recovery patterns of Mojave Desert vegetation in an aqueduct pipeline corridor after 36 years: I. Perennial shrubs and grasses
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Kristin H. Berry, Timothy A. Gowan, James F. Weigand, and Jeremy S. Mack
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0106 biological sciences ,010504 meteorology & atmospheric sciences ,Ecology ,biology ,Perennial plant ,Species diversity ,Vegetation ,biology.organism_classification ,Ambrosia dumosa ,010603 evolutionary biology ,01 natural sciences ,Grayia spinosa ,Geography ,Road verge ,Species richness ,Larrea ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences ,Earth-Surface Processes - Abstract
We studied recovery of 21 perennial plant species along a severely disturbed aqueduct corridor in a Larrea tridentata-Ambrosia dumosa plant alliance in the Mojave Desert 36 years after construction. The 97-m wide corridor contained a central dirt road and buried aqueduct pipeline. We established transects at 0 m (road verge), 20 m and 40 m into the disturbance corridor, and at 100 m in undisturbed habitat (the control). Although total numbers of shrubs per transect did not vary significantly with distance from the verge, canopy cover of shrubs, species richness, and species diversity were higher in the control than at the verge and other distances. Canopy cover of common shrubs (Ericameria nauseosa, Ambrosia salsola, A. dumosa, L. tridentata, Grayia spinosa) and perennial grasses (Elymus elymoides, Poa secunda) also varied significantly by location. Discriminant analysis clearly separated the four distances based on plant composition. Patterns of recovery were bidirectional: secondary succession from the control into the disturbance corridor and inhibition from the verge in the direction of the control. Time estimated for species composition to resemble the control is dependent on location within the disturbance corridor and could be centuries at the road verge. Our findings have applications to other deserts.
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- 2016
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43. Bidirectional recovery patterns of Mojave Desert vegetation in an aqueduct pipeline corridor after 36 years: II. Annual plants
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Denise LaBerteaux, James F. Weigand, Jeremy S. Mack, Kristin H. Berry, and Timothy A. Gowan
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Hydrology ,Biomass (ecology) ,Secondary succession ,Ecology ,Species diversity ,Ecological succession ,Vegetation ,Environmental science ,Species richness ,Road verge ,Annual plant ,Ecology, Evolution, Behavior and Systematics ,Earth-Surface Processes - Abstract
We studied recovery of winter annual plants in a 97-m wide disturbed aqueduct corridor in the Mojave Desert 36 years after construction. We established plots at 0, 20, and 40 m from the road verge at the corridor center and at 100 m in undisturbed vegetation. We recorded 47 annual species, of which 41 were native and six were exotic. Exotic species composed from 64 to 91% of total biomass. We describe a bilateral process of recovery: from the road verge to the outward edge of the corridor and from undisturbed habitat into the corridor. Native annual plants significantly increased in richness from road verge to undisturbed vegetation, but not in density, biomass, or cover. In contrast, exotic annual plants increased in density, biomass, cover and richness with increasing distance from the road verge. The species of colonizing shrubs and type of canopy cover affected density, biomass, and richness of annuals. Species composition of native annuals differed significantly by distance, suggesting secondary succession. In general, native annuals were closer to achieving recovery on the 40-m plots than at the road verge. Recovery estimates were in centuries and dependent on location, canopy type, and whether considering all annuals or natives only.
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- 2015
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44. Factors Affecting the Thermal Environment of Agassiz's Desert Tortoise (Gopherus agassizii) Cover Sites in the Central Mojave Desert during Periods of Temperature Extremes
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Jeremy S. Mack, Andrea S. Carlson, Kristin H. Berry, and David M. Miller
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Surficial geology ,Hydrology ,Tortoise ,Ecology ,Soil cover ,Multivariate regression tree ,Opening height ,Animal Science and Zoology ,Cover (algebra) ,Biology ,Extreme temperature ,Ecology, Evolution, Behavior and Systematics - Abstract
Agassiz's Desert Tortoises (Gopherus agassizii) spend >95% of their lives underground in cover sites that serve as thermal buffers from temperatures, which can fluctuate >40°C on a daily and seasonal basis. We monitored temperatures at 30 active tortoise cover sites within the Soda Mountains, San Bernardino County, California, from February 2004 to September 2006. Cover sites varied in type and structural characteristics, including opening height and width, soil cover depth over the opening, aspect, tunnel length, and surficial geology. We focused our analyses on periods of extreme temperature: in summer, between July 1 and September 1, and winter, between November 1 and February 15. With the use of multivariate regression tree analyses, we found cover-site temperatures were influenced largely by tunnel length and subsequently opening width and soil cover. Linear regression models further showed that increasing tunnel length increased temperature stability and dampened seasonal temperature extrem...
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- 2015
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45. Screening mammography among nursing home residents in the United States: Current guidelines and practice
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Deborah S Mack, Kate L. Lapane, Mara M. Epstein, Robin E. Clark, and Catherine Dubé
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medicine.medical_specialty ,Population ,Context (language use) ,Breast Neoplasms ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,Breast cancer screening ,0302 clinical medicine ,Medicine ,Homes for the Aged ,Humans ,Mass Screening ,030212 general & internal medicine ,Medicare Part B ,education ,Aged ,Aged, 80 and over ,Minimum Data Set ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Guideline ,Confidence interval ,United States ,Nursing Homes ,Cross-Sectional Studies ,Oncology ,Family medicine ,Female ,Geriatrics and Gerontology ,business ,Medicaid ,Mammography - Abstract
Objective United States (US) guidelines regarding when to stop routine breast cancer screening remain unclear. No national studies to-date have evaluated the use of screening mammography among US long-stay nursing home residents. This cross-sectional study was designed to identify prevalence, predictors, and geographic variation of screening mammography among that population in the context of current US guidelines. Materials and Methods Screening mammography prevalence, identified with Physician/Supplier Part B claims and stratified by guideline age classification (65–74, ≥75 years), was estimated for all women aged ≥65 years residing in US Medicare- and Medicaid- certified nursing homes (≥1 year) with an annual Minimum Data Set (MDS) 3.0 assessment, continuous Medicare Part B enrollment, and no clinical indication for screening mammography as of 2011 (n = 389,821). The associations between resident- and regional- level factors, and screening mammography, were estimated by crude and adjusted prevalence ratios from robust Poisson regressions clustered by facility. Results Women on average were 85.4 (standard deviation ±8.1) years old, 77.9% were disabled, and 76.3% cognitively impaired. Screening mammography prevalence was 7.1% among those aged 65–74 years (95% Confidence Interval (CI): 6.8%–7.3%) and 1.7% among those ≥75 years (95% CI, 1.7%–1.8%), with geographic variation observed. Predictors of screening in both age groups included race, cognitive impairment, frailty, hospice, and some comorbidities. Conclusions These results shed light on the current screening mammography practices in US nursing homes. Thoughtful consideration about individual screening recommendations and the implementation of more clear guidelines for this special population are warranted to prevent overscreening.
- Published
- 2018
46. Cognitive Impairment and Pain Among Nursing Home Residents With Cancer
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Kate L. Lapane, Catherine Dubé, Deborah S Mack, and Jacob N. Hunnicutt
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Male ,medicine.medical_specialty ,Context (language use) ,Article ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Neoplasms ,medicine ,Prevalence ,Humans ,Pain Management ,Cognitive Dysfunction ,030212 general & internal medicine ,Effects of sleep deprivation on cognitive performance ,Poisson regression ,Cognitive impairment ,General Nursing ,Aged ,Pain Measurement ,Aged, 80 and over ,Minimum Data Set ,business.industry ,Cancer ,Cancer Pain ,Pain management ,Middle Aged ,medicine.disease ,Nursing Homes ,Anesthesiology and Pain Medicine ,Cross-Sectional Studies ,symbols ,Physical therapy ,Female ,Neurology (clinical) ,business ,Nursing homes ,030217 neurology & neurosurgery - Abstract
Context The prevalence of pain and its management has been shown to be inversely associated with greater levels of cognitive impairment. Objectives To evaluate whether the documentation and management of pain varies by level of cognitive impairment among nursing home residents with cancer. Methods Using a cross-sectional study, we identified all newly admitted U.S. nursing home residents with a cancer diagnosis in 2011–2012 (n = 367,462). Minimum Data Set 3.0 admission assessment was used to evaluate pain/pain management in the past five days and cognitive impairment (assessed via the Brief Interview for Mental Status or the Cognitive Performance Scale for 91.6% and 8.4%, respectively). Adjusted prevalence ratios with 95% CI were estimated from robust Poisson regression models. Results For those with staff-assessed pain, pain prevalence was 55.5% with no/mild cognitive impairment and 50.5% in those severely impaired. Pain was common in those able to self-report (67.9% no/mild, 55.9% moderate, and 41.8% severe cognitive impairment). Greater cognitive impairment was associated with reduced prevalence of any pain (adjusted prevalence ratio severe vs. no/mild cognitive impairment; self-assessed pain 0.77; 95% CI 0.76–0.78; staff-assessed pain 0.96; 95% CI 0.93–0.99). Pharmacologic pain management was less prevalent in those with severe cognitive impairment (59.4% vs. 74.9% in those with no/mild cognitive impairment). Conclusion In nursing home residents with cancer, pain was less frequently documented in those with severe cognitive impairment, which may lead to less frequent use of treatments for pain. Techniques to improve documentation and treatment of pain in nursing home residents with cognitive impairment are needed.
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- 2017
47. Ferromagnetic order controlled by the magnetic interface of LaNiO3/La2/3Ca1/3MnO3 superlattices
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S. Soltan, S. Macke, S. E. Ilse, T. Pennycook, Z. L. Zhang, G. Christiani, E. Benckiser, G. Schütz, and E. Goering
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Medicine ,Science - Abstract
Abstract Interface engineering in complex oxide superlattices is a growing field, enabling manipulation of the exceptional properties of these materials, and also providing access to new phases and emergent physical phenomena. Here we demonstrate how interfacial interactions can induce a complex charge and spin structure in a bulk paramagnetic material. We investigate a superlattice (SLs) consisting of paramagnetic LaNiO3 (LNO) and highly spin-polarized ferromagnetic La2/3Ca1/3MnO3 (LCMO), grown on SrTiO3 (001) substrate. We observed emerging magnetism in LNO through an exchange bias mechanism at the interfaces in X-ray resonant magnetic reflectivity. We find non-symmetric interface induced magnetization profiles in LNO and LCMO which we relate to a periodic complex charge and spin superstructure. High resolution scanning transmission electron microscopy images reveal that the upper and lower interfaces exhibit no significant structural variations. The different long range magnetic order emerging in LNO layers demonstrates the enormous potential of interfacial reconstruction as a tool for tailored electronic properties.
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- 2023
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48. Distance to human populations influences epidemiology of respiratory disease in desert tortoises
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Ashley A. Coble, Julie L. Yee, William M. Perry, Mary Bomberger Brown, Kristin H. Berry, Jeremy S. Mack, and Kemp M. Anderson
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medicine.medical_specialty ,Ecology ,Mycoplasma agassizii ,Tortoise ,Prevalence ,Vegetation ,Biology ,biology.organism_classification ,Spatial distribution ,Specific antibody ,Habitat ,Epidemiology ,medicine ,General Earth and Planetary Sciences ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation ,General Environmental Science - Abstract
We explored variables likely to affect health of Agassiz's desert tortoises (Gopherus agassizii) in a 1,183-km2 study area in the central Mojave Desert of California between 2005 and 2008. We evaluated 1,004 tortoises for prevalence and spatial distribution of 2 pathogens, Mycoplasma agassizii and M. testudineum, that cause upper respiratory tract disease. We defined tortoises as test-positive if they were positive by culture and/or DNA identification or positive or suspect for specific antibody for either of the two pathogens. We used covariates of habitat (vegetation, elevation, slope, and aspect), tortoise size and sex, distance from another test-positive tortoise, and anthropogenic variables (distances to roads, agricultural areas, playas, urban areas, and centroids of human-populated census blocks). We used both logistic regression models and regression trees to evaluate the 2 species of Mycoplasma separately. The prevalence of test-positive tortoises was low: 1.49% (15/1,004) for M. agassizii and 2.89% (29/1,004) for M. testudineum. The spatial distributions of test-positive tortoises for the 2 Mycoplasma species showed little overlap; only 2 tortoises were test-positive for both diseases. However, the spatial distributions did not differ statistically between the 2 species. We consistently found higher prevalence of test-positive tortoises with shorter distances to centroids of human-populated census blocks. The relationship between distance to human-populated census blocks and tortoises that are test-positive for M. agassizii and potentially M. testudineum may be related to release or escape of captive tortoises because the prevalence of M. agassizii in captive tortoises is high. Our findings have application to other species of chelonians where both domestic captive and wild populations exist. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
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- 2014
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49. MEDULLOBLASTOMA
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G. Vaidyanathan, S. Gururangan, D. Bigner, M. Zalutsky, M. Morfouace, A. Shelat, J. Megan, B. B. Freeman, S. Robinson, S. Throm, J. M. Olson, X.-N. Li, K. R. Guy, G. Robinson, C. Stewart, A. Gajjar, M. Roussel, N. Sirachainan, S. Pakakasama, U. Anurathapan, A. Hansasuta, M. Dhanachai, C. Khongkhatithum, S. Hongeng, A. Feroze, K.-S. Lee, S. Gholamin, Z. Wu, B. Lu, S. Mitra, S. Cheshier, P. Northcott, C. Lee, T. Zichner, P. Lichter, J. Korbel, R. Wechsler-Reya, S. Pfister, I. P. T. Project, K. K.-W. Li, T. Xia, F. M. T. Ma, R. Zhang, L. Zhou, K.-M. Lau, H.-K. Ng, L. Lafay-Cousin, S. Chi, J. Madden, A. Smith, E. Wells, E. Owens, D. Strother, N. Foreman, R. Packer, E. Bouffet, T. Wataya, J. Peacock, M. D. Taylor, D. Ivanov, M. Garnett, T. Parker, C. Alexander, L. Meijer, R. Grundy, P. Gellert, M. Ashford, D. Walker, J. Brent, F. Z. Cader, D. Ford, A. Kay, R. Walsh, G. Solanki, A. Peet, M. English, T. Shalaby, G. Fiaschetti, S. Baulande, N. Gerber, M. Baumgartner, M. Grotzer, T. Hayase, Y. Kawahara, M. Yagi, T. Minami, N. Kanai, T. Yamaguchi, A. Gomi, A. Morimoto, R. Hill, S. Kuijper, J. Lindsey, E. Schwalbe, K. Barker, J. Boult, D. Williamson, Z. Ahmad, A. Hallsworth, S. Ryan, E. Poon, R. Ruddle, F. Raynaud, L. Howell, C. Kwok, A. Joshi, S. L. Nicholson, S. Crosier, S. Wharton, K. Robson, A. Michalski, D. Hargrave, T. Jacques, B. Pizer, S. Bailey, F. Swartling, K. Petrie, W. Weiss, L. Chesler, S. Clifford, L. Kitanovski, T. Prelog, B. F. Kotnik, M. Debeljak, M. A. Grotzer, A. Gevorgian, E. Morozova, I. Kazantsev, T. Iukhta, S. Safonova, E. Kumirova, Y. Punanov, B. Afanasyev, O. Zheludkova, W. Grajkowska, M. Pronicki, B. Cukrowska, B. Dembowska-Baginska, M. Lastowska, A. Murase, S. Nobusawa, Y. Gemma, F. Yamazaki, A. Masuzawa, T. Uno, T. Osumi, Y. Shioda, C. Kiyotani, T. Mori, K. Matsumoto, H. Ogiwara, N. Morota, J. Hirato, A. Nakazawa, K. Terashima, T. Fay-McClymont, K. Walsh, D. Mabbott, D. Sturm, P. A. Northcott, D. T. W. Jones, A. Korshunov, S. M. Pfister, M. Kool, C. Hooper, S. Hawes, U. Kees, N. Gottardo, P. Dallas, A. Siegfried, A. I. Bertozzi, A. Sevely, N. Loukh, C. Munzer, C. Miquel, F. Bourdeaut, T. Pietsch, C. Dufour, M. B. Delisle, D. Kawauchi, J. Rehg, D. Finkelstein, F. Zindy, T. Phoenix, R. Gilbertson, J. Trubicka, M. Borucka-Mankiewicz, E. Ciara, K. Chrzanowska, M. Perek-Polnik, D. Abramczuk-Piekutowska, D. Jurkiewicz, S. Luczak, P. Kowalski, M. Krajewska-Walasek, C. Sheila, S. Lee, C. Foster, B. Manoranjan, M. Pambit, R. Berns, A. Fotovati, C. Venugopal, K. O'Halloran, A. Narendran, C. Hawkins, V. Ramaswamy, M. Taylor, A. Singhal, J. Hukin, R. Rassekh, S. Yip, S. Singh, C. Duhman, S. Dunn, T. Chen, S. Rush, H. Fuji, Y. Ishida, T. Onoe, T. Kanda, Y. Kase, H. Yamashita, S. Murayama, Y. Nakasu, T. Kurimoto, A. Kondo, S. Sakaguchi, J. Fujimura, M. Saito, T. Arakawa, H. Arai, T. Shimizu, E. Jurkiewicz, P. Daszkiewicz, M. Drogosiewicz, V. Hovestadt, I. Buchhalter, N. N. Jager, A. Stuetz, P. Johann, C. Schmidt, M. Ryzhova, P. Landgraf, M. Hasselblatt, U. Schuller, M.-L. Yaspo, A. von Deimling, R. Eils, A. Modi, M. Patel, M. Berk, L.-x. Wang, G. Plautz, H. Camara-Costa, A. Resch, C. Lalande, V. Kieffer, G. Poggi, C. Kennedy, K. Bull, G. Calaminus, J. Grill, F. Doz, S. Rutkowski, M. Massimino, R.-D. Kortmann, B. Lannering, G. Dellatolas, M. Chevignard, D. Solecki, P. McKinnon, J. Olson, J. Hayden, D. Ellison, M. Buss, M. Remke, J. Lee, T. Caspary, R. Castellino, M. Sabel, G. Gustafsson, G. Fleischhack, M. Benesch, A. Navajas, R. Reddingius, M.-B. Delisle, D. Lafon, N. Sevenet, G. Pierron, O. Delattre, J. Ecker, I. Oehme, R. Mazitschek, M. Lodrini, H. E. Deubzer, A. E. Kulozik, O. Witt, T. Milde, D. Patmore, N. Boulos, K. Wright, S. Boop, T. Janicki, S. Burzynski, G. Burzynski, A. Marszalek, J. Triscott, M. Green, S. R. Rassekh, B. Toyota, C. Dunham, S. E. Dunn, K.-W. Liu, Y. Pei, L. Genovesi, P. Ji, M. Davis, C. G. Ng, Y.-J. Cho, N. Jenkins, N. Copeland, B. Wainwright, Y. Tang, S. Schubert, B. Nguyen, S. Masoud, A. Lee, M. Willardson, P. Bandopadhayay, G. Bergthold, S. Atwood, R. Whitson, J. Qi, R. Beroukhim, J. Tang, A. Oro, B. Link, J. Bradner, S. G. Vallero, D. Bertin, M. E. Basso, C. Milanaccio, P. Peretta, A. Cama, A. Mussano, S. Barra, G. Morana, I. Morra, P. Nozza, F. Fagioli, M. L. Garre, A. Darabi, E. Sanden, E. Visse, N. Stahl, P. Siesjo, D. Vaka, F. Vasquez, B. Weir, G. Cowley, C. Keller, W. Hahn, I. C. Gibbs, S. Partap, K. Yeom, M. Martinez, H. Vogel, S. S. Donaldson, P. Fisher, S. Perreault, L. Guerrini-Rousseau, S. Pujet, V. Kieffer-Renaux, M. A. Raquin, P. Varlet, A. Longaud, C. Sainte-Rose, D. Valteau-Couanet, J. Staal, L. S. Lau, H. Zhang, W. J. Ingram, Y. J. Cho, Y. Hathout, K. Brown, B. R. Rood, M. Handler, T. Hankinson, B. K. Kleinschmidt-Demasters, S. Hutter, D. T. Jones, N. Kagawa, R. Hirayama, N. Kijima, Y. Chiba, M. Kinoshita, K. Takano, D. Eino, S. Fukuya, F. Yamamoto, K. Nakanishi, N. Hashimoto, Y. Hashii, J. Hara, T. Yoshimine, J. Wang, C. Guo, Q. Yang, Z. Chen, I. Filipek, E. Swieszkowska, M. Tarasinska, D. Perek, R. Kebudi, B. Koc, O. Gorgun, F. Y. Agaoglu, J. Wolff, E. Darendeliler, K. Kerl, J. Gronych, J. McGlade, R. Endersby, H. Hii, T. Johns, J. Sastry, D. Murphy, M. Ronghe, C. Cunningham, F. Cowie, R. Jones, A. Calisto, M. Sangra, C. Mathieson, J. Brown, K. Phuakpet, V. Larouche, U. Bartels, T. Ishida, D. Hasegawa, K. Miyata, S. Ochi, A. Saito, A. Kozaki, T. Yanai, K. Kawasaki, K. Yamamoto, A. Kawamura, T. Nagashima, Y. Akasaka, T. Soejima, M. Yoshida, Y. Kosaka, A. von Bueren, T. Goschzik, R. Kortmann, K. von Hoff, C. Friedrich, A. z. Muehlen, M. Warmuth-Metz, N. Soerensen, F. Deinlein, I. Zwiener, A. Faldum, J. Kuehl, K. KRAMER, N. P. -Taskar, P. Zanzonico, J. L. Humm, S. L. Wolden, N.-K. V. Cheung, S. Venkataraman, I. Alimova, P. Harris, D. Birks, I. Balakrishnan, A. Griesinger, N. K. Foreman, R. Vibhakar, A. Margol, N. Robison, J. Gnanachandran, L. Hung, R. Kennedy, M. Vali, G. Dhall, J. Finlay, A. Erdrich-Epstein, M. Krieger, R. Drissi, M. Fouladi, F. Gilles, A. Judkins, R. Sposto, S. Asgharzadeh, A. Peyrl, M. Chocholous, S. Holm, P. Grillner, K. Blomgren, A. Azizi, T. Czech, B. Gustafsson, K. Dieckmann, U. Leiss, I. Slavc, S. Babelyan, I. Dolgopolov, R. Pimenov, G. Mentkevich, S. Gorelishev, M. Laskov, A. O. von Bueren, J. Nowak, R. D. Kortmann, M. Mynarek, K. Muller, N. U. Gerber, H. Ottensmeier, R. Kwiecien, M. Yankelevich, V. Boyarshinov, I. Glekov, S. Ozerov, S. Gorelyshev, A. Popa, N. Subbotina, A. M. Martin, C. Nirschl, M. Polanczyk, R. Bell, D. Martinez, L. M. Sullivan, M. Santi, P. C. Burger, J. M. Taube, C. G. Drake, D. M. Pardoll, M. Lim, L. Li, W.-G. Wang, J.-X. Pu, H.-D. Sun, R. Ruggieri, M. H. Symons, M. I. Vanan, S. Bolin, S. Schumacher, R. Zeid, F. Yu, N. Vue, W. Gibson, B. Paolella, F. J. Swartling, M. W. Kieran, J. E. Bradner, O. Maher, S. Khatua, N. Tarek, W. Zaky, T. Gupta, S. Mohanty, S. Kannan, R. Jalali, E. Kapitza, D. Denkhaus, A. z. Muhlen, D. G. van Vuurden, M. Garami, J. Fangusaro, T. B. Davidson, M. J. G. da Costa, J. Sterba, S. C. Clifford, J. L. Finlay, R. Schmidt, J. Felsberg, H. Skladny, F. Cremer, G. Reifenberger, R. Kunder, E. Sridhar, A. A. Moiyadi, A. Goel, N. Goel, N. Shirsat, R. Othman, L. Storer, I. Kerr, B. Coyle, N. Law, M. L. Smith, M. Greenberg, S. Laughlin, D. Malkin, F. Liu, I. Moxon-Emre, N. Scantlebury, A. Nasir, D. Onion, A. Lourdusamy, A. Grabowska, Y. Cai, T. Bradshaw, R. S. S. de Medeiros, A. Beaugrand, S. Soares, S. Epelman, W. Wang, M. Sultan, R. J. Wechsler-Reya, M. Zapatka, B. Radlwimmer, D. Alderete, L. Baroni, F. Lubinieki, F. Auad, M. L. Gonzalez, W. Puya, P. Pacheco, O. Aurtenetxe, A. Gaffar, L. Gros, O. Cruz, C. Calvo, N. Shinojima, H. Nakamura, J.-i. Kuratsu, A. Hanaford, C. Eberhart, T. Archer, P. Tamayo, S. Pomeroy, E. Raabe, K. De Braganca, S. Gilheeney, Y. Khakoo, K. Kramer, S. Wolden, I. Dunkel, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, D. Shih, X. Wang, C. Faria, C. Raybaud, U. Tabori, J. Rutka, S. Jacobs, F. De Vathaire, I. Diallo, D. Llanas, C. Verez, F. Diop, A. Kahlouche, S. Puget, E. Thompson, E. Prince, V. Amani, P. Sin-Chan, M. Lu, C. Kleinman, T. Spence, D. Picard, K. C. Ho, J. Chan, J. Majewski, N. Jabado, P. Dirks, A. Huang, J. R. Madden, A. M. Donson, D. M. Mirsky, A. Dubuc, S. Mack, D. Gendoo, B. Luu, T. MacDonald, T. Van Meter, S. Croul, A. Laureano, W. Brugmann, C. Denman, H. Singh, H. Huls, J. Moyes, D. Sandberg, L. Silla, L. Cooper, and D. Lee
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Oncology ,Abstracts ,Cancer Research ,medicine.medical_specialty ,Cns pnet ,business.industry ,Internal medicine ,Meta-analysis ,medicine ,Neurology (clinical) ,business - Published
- 2014
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50. Multicomponent phase transition kinetics in cereal foam—Part I: developing a lattice Boltzmann model
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Mohamed A. Hussein, Thomas Becker, and S. Mack
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Length scale ,Phase transition ,Chemistry ,Lattice Boltzmann methods ,Thermodynamics ,Condensed Matter Physics ,Thermal conduction ,Electronic, Optical and Magnetic Materials ,Mass transfer ,visual_art ,Heat transfer ,Materials Chemistry ,visual_art.visual_art_medium ,Process optimization ,Ceramic - Abstract
Foam thermo-physics is a significant point of interest in current research in a broad range of applications reaching from material science, geology, chemical, biotechnology, ceramic processing to food science. The latter involves the challenge of continuous quality in combination with high-temperature processing. Thermal treatment strongly influences foam structure, stability and as well enforces chemical reactions or physical processes such as phase transitions. From a process engineering point of view, such reactions can be used for process optimization considerations. In cereal foam, heat transfer is suggested to depend, besides heat conduction in the lamella, on evaporation–condensation processes inside the foam bubbles. According to the meso-scale incidence of physical processes within complex foam micro-structures, the lattice Boltzmann method verifies its application to numerical investigations on the considered length scale. Thus, the objective of this study is the development of a lattice Boltzmann model covering heat and mass diffusion in combination with phase transition processes.
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- 2014
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