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1. Measurement of shower development and its Molière radius with a four-plane LumiCal test set-up

Author

H. Abramowicz, A. Abusleme, K. Afanaciev, Y. Benhammou, L. Bortko, O. Borysov, M. Borysova, I. Bozovic-Jelisavcic, G. Chelkov, W. Daniluk, D. Dannheim, K. Elsener, M. Firlej, E. Firu, T. Fiutowski, V. Ghenescu, M. Gostkin, M. Hempel, H. Henschel, M. Idzik, A. Ignatenko, A. Ishikawa, S. Kananov, O. Karacheban, W. Klempt, S. Kotov, J. Kotula, D. Kozhevnikov, V. Kruchonok, B. Krupa, Sz. Kulis, W. Lange, J. Leonard, T. Lesiak, A. Levy, I. Levy, W. Lohmann, S. Lukic, J. Moron, A. Moszczynski, A. T. Neagu, F.-X. Nuiry, M. Pandurovic, B. Pawlik, T. Preda, O. Rosenblat, A. Sailer, B. Schumm, S. Schuwalow, I. Smiljanic, P. Smolyanskiy, K. Swientek, P. Terlecki, U. I. Uggerhoj, T. N. Wistisen, T. Wojton, H. Yamamoto, L. Zawiejski, I. S. Zgura, and A. Zhemchugov

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A prototype of a luminometer, designed for a future $$e^+e^-$$ e+e- collider detector, and consisting at present of a four-plane module, was tested in the CERN PS accelerator T9 beam. The objective of this beam test was to demonstrate a multi-plane tungsten/silicon operation, to study the development of the electromagnetic shower and to compare it with MC simulations. The Molière radius has been determined to be 24.0 ± 0.6 (stat.) ± 1.5 (syst.) mm using a parametrization of the shower shape. Very good agreement was found between data and a detailed Geant4 simulation.

Published
2018
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2. Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia

Author

V Borghesani, CL Dale, S Lukic, LBN Hinkley, M Lauricella, W Shwe, D Mizuiri, S Honma, Z Miller, B Miller, JF Houde, ML Gorno-Tempini, and SS Nagarajan

Subjects
primary progressive aphasia, semantic categorization, magnetoencephalography, semantic variant ppa, semantic dementia, anterior temporal lobe, Medicine, Science, Biology (General), QH301-705.5
Abstract

Semantic representations are processed along a posterior-to-anterior gradient reflecting a shift from perceptual (e.g., it has eight legs) to conceptual (e.g., venomous spiders are rare) information. One critical region is the anterior temporal lobe (ATL): patients with semantic variant primary progressive aphasia (svPPA), a clinical syndrome associated with ATL neurodegeneration, manifest a deep loss of semantic knowledge. We test the hypothesis that svPPA patients perform semantic tasks by over-recruiting areas implicated in perceptual processing. We compared MEG recordings of svPPA patients and healthy controls during a categorization task. While behavioral performance did not differ, svPPA patients showed indications of greater activation over bilateral occipital cortices and superior temporal gyrus, and inconsistent engagement of frontal regions. These findings suggest a pervasive reorganization of brain networks in response to ATL neurodegeneration: the loss of this critical hub leads to a dysregulated (semantic) control system, and defective semantic representations are seemingly compensated via enhanced perceptual processing.

Published
2021
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3. OC.06.3 POST-COVID-19 IRRITABLE BOWEL SYNDROME

Author

G. Marasco, C. Cremon, M.R. Barbaro, F. Falangone, G. Cacciari, A. Kagramanova, D. Bordin, V. Drug, P. Fusaroli, S. Mohamed, C. Ricci, M. Bellini, M. Rahman, L. Melcarne, J. Santos, S. Bor, S. Yapali, S. Lukic, M. Trajkovska, K. Hod, D. Dumitrascu, A. Pietrangelo, M. Simren, U. Ghoshal, O. Kolokolnikova, A. Colecchia, J. Serra, G. Maconi, R. De Giorgio, S. Danese, P. Portincasa, A. Di Sabatino, M. Maggio, E. Philippou, V. Stanghellini, and G. Barbara

Subjects
Hepatology, Gastroenterology
Published
2023

4. Riluzole, a glutamate modulator, slows cerebral glucose metabolism decline in patients with Alzheimer’s disease

Author

Neeva Shafiian, P. David Mozley, Kathleen Dowd, Dawn C. Matthews, Caroline Meuser, Jihyun Lee, Nicholas Hampilos, Randolph D. Andrews, Ana S. Lukic, Diamanto Tsakanikas, Mary Sano, Howard Fillit, Xiangling Mao, Bruce S. McEwen, Ana C. Pereira, Dikoma C. Shungu, and Caroline S. Jiang

Subjects
Male, Oncology, medicine.medical_specialty, Precuneus, Hippocampus, Placebo, Double-Blind Method, Alzheimer Disease, Internal medicine, medicine, Humans, Effects of sleep deprivation on cognitive performance, Amyotrophic lateral sclerosis, Aged, Aged, 80 and over, Riluzole, business.industry, Glutamate receptor, Brain, Original Articles, Middle Aged, medicine.disease, Glucose, Neuroprotective Agents, medicine.anatomical_structure, Posterior cingulate, Female, Neurology (clinical), business, medicine.drug
Abstract

Dysregulation of glutamatergic neural circuits has been implicated in a cycle of toxicity, believed among the neurobiological underpinning of Alzheimer’s disease. Previously, we reported preclinical evidence that the glutamate modulator riluzole, which is FDA approved for the treatment of amyotrophic lateral sclerosis, has potential benefits on cognition, structural and molecular markers of ageing and Alzheimer’s disease. The objective of this study was to evaluate in a pilot clinical trial, using neuroimaging biomarkers, the potential efficacy and safety of riluzole in patients with Alzheimer’s disease as compared to placebo. A 6-month phase 2 double-blind, randomized, placebo-controlled study was conducted at two sites. Participants consisted of males and females, 50 to 95 years of age, with a clinical diagnosis of probable Alzheimer’s disease, and Mini-Mental State Examination between 19 and 27. Ninety-four participants were screened, 50 participants who met inclusion criteria were randomly assigned to receive 50 mg riluzole (n = 26) or placebo (n = 24) twice a day. Twenty-two riluzole-treated and 20 placebo participants completed the study. Primary end points were baseline to 6 months changes in (i) cerebral glucose metabolism as measured with fluorodeoxyglucose-PET in prespecified regions of interest (hippocampus, posterior cingulate, precuneus, lateral temporal, inferior parietal, frontal); and (ii) changes in posterior cingulate levels of the neuronal viability marker N-acetylaspartate as measured with in vivo proton magnetic resonance spectroscopy. Secondary outcome measures were neuropsychological testing for correlation with neuroimaging biomarkers and in vivo measures of glutamate in posterior cingulate measured with magnetic resonance spectroscopy as a potential marker of target engagement. Measures of cerebral glucose metabolism, a well-established Alzheimer’s disease biomarker and predictor of disease progression, declined significantly less in several prespecified regions of interest with the most robust effect in posterior cingulate, and effects in precuneus, lateral temporal, right hippocampus and frontal cortex in riluzole-treated participants in comparison to the placebo group. No group effect was found in measures of N-acetylaspartate levels. A positive correlation was observed between cognitive measures and regional cerebral glucose metabolism. A group × visit interaction was observed in glutamate levels in posterior cingulate, potentially suggesting engagement of glutamatergic system by riluzole. In vivo glutamate levels positively correlated with cognitive performance. These findings support our main primary hypothesis that cerebral glucose metabolism would be better preserved in the riluzole-treated group than in the placebo group and provide a rationale for more powered, longer duration studies of riluzole as a potential intervention for Alzheimer’s disease.

Published
2021

11. Exploratory imaging outcomes of a phase 1b/2a clinical trial of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: Structural effects and functional connectivity outcomes

Author

Adam C, Raikes, Gerson D, Hernandez, Dawn C, Matthews, Ana S, Lukic, Meng, Law, Yonggang, Shi, Lon S, Schneider, and Roberta D, Brinton

Subjects
Psychiatry and Mental health, Neurology (clinical)
Abstract

Allopregnanolone (ALLO), an endogenous neurosteroid, promoted neurogenesis and oligogenesis and restored cognitive function in animal models of Alzheimer's disease (AD). Based on these discovery research findings, we conducted a randomized-controlled phase 1b/2a multiple ascending dose trial of ALLO in persons with early AD (NCT02221622) to assess safety, tolerability, and pharmacokinetics. Exploratory imaging outcomes to determine whether ALLO impacted hippocampal structure, white matter integrity, and functional connectivity are reported.Twenty-four individuals participated in the trial (Rate of decline in hippocampal volume was slowed, and in some cases reversed, in the ALLO group compared to placebo. Gain of hippocampal volume was evident inIndicators of regeneration from previous preclinical studies and these exploratory MRI-based outcomes from this phase 1b/2a clinical cohort support advancement to a phase 2 proof-of-concept efficacy clinical trial of ALLO as a regenerative therapeutic for mild AD (REGEN-BRAIN study; NCT04838301).

Published
2022

12. Measurement of neurodegeneration using a multivariate early frame amyloid PET classifier

Author

Dawn C, Matthews, Ana S, Lukic, Randolph D, Andrews, Miles N, Wernick, Stephen C, Strother, and Mark E, Schmidt

Abstract

Amyloid measurement provides important confirmation of pathology for Alzheimer's disease (AD) clinical trials. However, many amyloid positive (Am+) early-stage subjects do not worsen clinically during a clinical trial, and a neurodegenerative measure predictive of decline could provide critical information. Studies have shown correspondence between perfusion measured by early amyloid frames post-tracer injection and fluorodeoxyglucose (FDG) positron emission tomography (PET), but with limitations in sensitivity. Multivariate machine learning approaches may offer a more sensitive means for detection of disease related changes as we have demonstrated with FDG.Using summed dynamic florbetapir image frames acquired during the first 6 minutes post-injection for 107 Alzheimer's Disease Neuroimaging Initiative subjects, we applied optimized machine learning to develop and test image classifiers aimed at measuring AD progression. Early frame amyloid (EFA) classification was compared to that of an independently developed FDG PET AD progression classifier by scoring the FDG scans of the same subjects at the same time point. Score distributions and correlation with clinical endpoints were compared to those obtained from FDG. Region of interest measures were compared between EFA and FDG to further understand discrimination performance.The EFA classifier produced a primary pattern similar to that of the FDG classifier whose expression correlated highly with the FDG pattern (R-squared 0.71), discriminated cognitively normal (NL) amyloid negative (Am-) subjects from all Am+ groups, and that correlated in Am+ subjects with Mini-Mental State Examination, Clinical Dementia Rating Sum of Boxes, and Alzheimer's Disease Assessment Scale-13-item Cognitive subscale (Our results support the ability to use EFA with a multivariate machine learning-derived classifier to obtain a sensitive measure of AD-related loss in neuronal function that correlates with FDG PET in preclinical and early prodromal stages as well as in late mild cognitive impairment and dementia.The summed initial post-injection minutes of florbetapir positron emission tomography correlate with fluorodeoxyglucose.A machine learning classifier enabled sensitive detection of early prodromal Alzheimer's disease.Early frame amyloid (EFA) classifier scores correlate with subsequent change in Mini-Mental State Examination, Clinical Dementia Rating Sum of Boxes, and Alzheimer's Disease Assessment Scale-13-item Cognitive subscale.EFA classifier effect sizes and clinical prediction outperformed region of interest standardized uptake value ratio.EFA classification may aid in stratifying patients to assess treatment effect.

Published
2021

13. Astrophysics at n_TOF facility

Author

G. Tagliente, U. Abbondanno, G. Aerts, H. Alvarez, F. Alvarez-Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulos, L. Audouin, G. Badurek, P. Baumann, F. Becvar, F. Belloni, E. Berthoumieux, S. Bisterzo, F. Calvino, M. Calviani, D. Cano-Ott, R. Capote, C. Carrapico, P. Cennini, V. Chepel, E. Chiaveri, N. Colonna, G. Cortes, A. Couture, J. Cox, M. Dahlfors, S. David, I. Dillman, C. Domingo-Pardo, W. Dridi, I. Duran, C. Eleftheriadis, M. Embid-Segura, L. Ferrant, A. Ferrari, R. Ferreira-Marques, K. Fujii, W. Furman, R. Gallino, I. Goncalves, E. Gonzalez-Romero, F. Gramegna, C. Guerrero, F. Gunsing, B. Haas, R. Haight, M. Heil, A. Herrera-Martinez, M. Igashira, E. Jericha, F. Kappeler, Y. Kadi, D. Karadimos, D. Karamanis, M. Kerveno, P. Koehler, E. Kossionides, M. Krticka, C. Lamboudis, H. Leeb, A. Lindote, I. Lopes, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, T. Martinez, C. Massimi, P. Mastinu, A. Mengoni, P. M.Milazzo, C. Moreau, M. Mosconi, F. Neves, H. Oberhummer, S. O'Brien, J. Pancin, C. Papachristodoulou, C. Papadopoulos, C. Paradela, N. Patronis, A. Pavlik, P. Pavlopoulos, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Plukis, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, C. Santos, L. Sarchiapone, I. Savvidis, C. Stephan, J. L. Tain, L. Tassan-Got, L. Tavora, R. Terlizzi, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, M. C. Vincente, V. Vlachoudis, R. Vlastou, F. Voss, S. Walter, H. Wendler, M. Wiescher, K. Wisshak

Subjects
Astrophysics, r-process., Atomic physics. Constitution and properties of matter, QC170-197
Abstract

The neutron time of flight (n_TOF) facility at CERN is a neutron spallation source, its white neutron energy spectrum ranges from thermal to several GeV, covering the full energy range of interest for nuclear astrophysics, in particular for measurements of the neutron capture cross-section required in s-process nucleosynthesis. This contribution gives an overview on the astrophysical program made at n_TOF facility, the results and the implications will be considered.

Published
2009
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14. Functionally Defective T Cells After Chemotherapy of B-Cell Malignancies Can Be Activated by the Tetravalent Bispecific CD19/CD3 Antibody AFM11

Author

Leo Rasche, Uwe Reusch, Margarete Karg, Johannes Duell, Eugene Zhukovsky, Dragana S Lukic, Max S. Topp, Florian Eisele, Martin Treder, Erich Rajkovic, Hermann Einsele, and Joachim Koch

Subjects
Adult, Male, 0301 basic medicine, Bendamustine, Cancer Research, Lymphoma, B-Cell, CD3 Complex, T-Lymphocytes, medicine.medical_treatment, Antigens, CD19, Immunology, CHOP, Lymphocyte Activation, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Antigen, hemic and lymphatic diseases, Antibodies, Bispecific, Antineoplastic Combined Chemotherapy Protocols, Leukemia, B-Cell, medicine, Humans, Immunology and Allergy, B cell, Aged, Pharmacology, business.industry, Immunotherapy, Middle Aged, medicine.disease, Lymphoma, Leukemia, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, Cytokines, Female, Rituximab, business, T-Lymphocytes, Cytotoxic, medicine.drug
Abstract

Immunotherapy of B-cell malignancies with bispecific antibodies is an emerging treatment option. However, not all patients benefit from these therapies, presumably due to pretreatment regimens. Therefore, we determined the effect of different treatment lines on the activity of T cells and their responsiveness to AFM11. AFM11 is a tetravalent, bispecific CD19/CD3 immunoengager based on Affimed's ROCK platform, currently being investigated in phase I clinical trials for non-Hodgkin lymphoma and acute lymphoblastic leukemia. T cells from B-cell lymphoma patients treated with either rituximab+bendamustine (R-Benda), rituximab+CHOP (R-CHOP), or with high-dose BEAM chemotherapy (HD-BEAM) and autologous HSCT were compared with T cells from healthy donors. Overall, in these patients, T-cell numbers were significantly reduced. To determine whether distinct chemotherapy affects AFM11 efficacy, functional T-cell assays were performed. It is interesting to note that, only in assays that combine target cell lysis, cytokine production and proliferation over 4 days at an effector to target ratio of up to 1:25 significant differences could be detected between the different treatment groups: T cells after R-CHOP showed only modest decrease in their functionality when compared with healthy controls, whereas R-Benda and HD-BEAM had a profound effect on AFM11-induced T-cell cytotoxicity. In conclusion, T cells from lymphoma patients are reduced in number and have functional defects following treatment with certain chemotherapy regimens, also reducing AFM11 efficacy. Importantly, AFM11 was still able to trigger B-cell-directed T-cell immunity in all treatment groups.

Published
2019

15. Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer's dementia

Author

Howard Feldman, Dawn C. Matthews, Randolph D. Andrews, James B. Leverenz, Howard Fillit, Aaron Ritter, Ronald G. Thomas, Ana S. Lukic, Carolyn Revta, Babak Tousi, Jefferson W. Kinney, Jeffrey L. Cummings, and Kate Zhong

Subjects
Oncology, Aging, Neurodegenerative, law.invention, chemistry.chemical_compound, Randomized controlled trial, Quality of life, law, Clinical endpoint, Memory span, Verbal fluency test, FDG-PET, Research Articles, rasagiline, QoL‐AD, Alzheimer's disease, Psychiatry and Mental health, tau PET, 6.1 Pharmaceuticals, Neurological, Biomedical Imaging, dopamine, Research Article, medicine.medical_specialty, FDG‐PET, QoL-AD, glucose metabolism, Clinical Trials and Supportive Activities, MAO‐B, flortaucipir, Placebo, MAO-B, Clinical Research, Internal medicine, Acquired Cognitive Impairment, medicine, Adverse effect, RC346-429, Rasagiline, business.industry, Neurosciences, RC952-954.6, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, chemistry, Geriatrics, Dementia, Neurology (clinical), Neurology. Diseases of the nervous system, business
Abstract

Author(s): Matthews, Dawn C; Ritter, Aaron; Thomas, Ronald G; Andrews, Randolph D; Lukic, Ana S; Revta, Carolyn; Kinney, Jefferson W; Tousi, Babak; Leverenz, James B; Fillit, Howard; Zhong, Kate; Feldman, Howard H; Cummings, Jeffrey | Abstract: BackgroundA Phase II proof of concept (POC) randomized clinical trial was conducted to evaluate the effects of rasagiline, a monoamine oxidase B (MAO-B) inhibitor approved for Parkinson disease, in mild to moderate Alzheimer's disease (AD). The primary objective was to determine if 1nmg of rasagiline daily for 24nweeks is associated with improved regional brain metabolism (fluorodeoxyglucose-positron emission tomography [FDG-PET]) compared to placebo. Secondary objectives included measurement of effects on tau PET and evaluation of directional consistency of clinical end points.MethodsThis was a double-blind, parallel group, placebo-controlled, community-based, three-site trial of 50 participants randomized 1:1 to receive oral rasagiline or placebo (NCT02359552). FDG-PET was analyzed for the presence of an AD-like pattern as an inclusion criterion and as a longitudinal outcome using prespecified regions of interest and voxel-based analyses. Tau PET was evaluated at baseline and longitudinally. Clinical outcomes were analyzed using an intention-to-treat (ITT) model.ResultsFifty patients were randomized and 43 completed treatment. The study met its primary end point, demonstrating favorable change in FDG-PET differences in rasagiline versus placebo in middle frontal (Pnln0.025), anterior cingulate (Pnln0.041), and striatal (Pnln0.023) regions. Clinical measures showed benefit in quality of life (Pnln0.04). Digit Span, verbal fluency, and Neuropsychiatric Inventory (NPI) showed non-significant directional favoring of rasagiline; no effects were observed in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) or activities of daily living. Rasagiline was generally well tolerated with low rates of adverse events and notably fewer neuropsychiatric symptoms in the active treatment group.DiscussionThese outcomes illustrate the potential benefits of rasagiline on clinical and neuroimaging measures in patients with mild to moderate AD. Rasagiline appears to affect neuronal activity in frontostriatal pathways, with associated clinical benefit potential warranting a more fully powered trial. This study illustrated the potential benefit of therapeutic repurposing and an experimental medicine proof-of-concept design with biomarkers to characterize patient and detect treatment response.

Published
2021

16. The effects of rasagiline on cerebral glucose metabolism, cognition, and tau in a double-blind, placebo-controlled Phase II clinical trial in Alzheimer’s dementia

Author

Dawn C. Matthews, Howard Fillit, Jefferson W. Kinney, Kate Zhong, Aaron Ritter, Babak Tousi, James B. Leverenz, Ana S. Lukic, Randolph D. Andrews, Carolyn Revta, Jeffrey L. Cummings, Ronald G. Thomas, and Howard H. Feldman

Subjects
Double blind, Rasagiline, Clinical trial, chemistry.chemical_compound, chemistry, business.industry, Cerebral glucose metabolism, Medicine, Cognition, Alzheimer s dementia, Pharmacology, Placebo, business
Abstract

BackgroundA Phase II proof of concept (POC) randomized clinical trial was conducted to evaluate the effects of rasagiline, a MAO-B inhibitor, in mild to moderate Alzheimer’s disease (AD). The primary objective was to determine if 1 mg of rasagiline daily for 24 weeks is associated with improved regional brain metabolism (fluoro-2-deoxyglucose positron emission tomography (FDG PET)) compared to placebo. Secondary objectives included use of flortaucipir PET to assess effects on tau pathology and determination of directional consistency of clinical endpoints.MethodsThis was a double-blind, parallel group, placebo-controlled, community-based, three-site trial of 50 participants randomized 1:1 to receive oral rasagiline or placebo (NCT02359552). FDG PET was analyzed at screening for the presence of an AD-like pattern as an inclusion criterion and as an outcome using prespecified regions of interest and image classification for longitudinal data. Participants who completed baseline and 24-week FDG PET scans and passed quality control were included in the primary analysis; secondary clinical outcomes were analyzed using an Intention-to-Treat (ITT) model.FindingsBetween May 19, 2015 and January 26, 2018, 96 participants were screened, 50 randomized, and 43 completed treatment. The study met its primary endpoint, demonstrating favorable change in FDG PET differences in rasagiline vs. placebo in middle frontal (2.5%,95%CI 0.3–4.7%,p

Published
2020

17. The Effects of Rasagiline on Glucose Metabolism and Cognition and Their Relationship to Tau Burden in a Double-Blind, Placebo-Controlled Phase Ii Clinical Trial of Participants with Alzheimer's Dementia

Author

Aaron Ritter, Carolyn Revta, Howard Fillit, James B. Leverenz, Howard Feldman, Kate Zhong, Jeffrey L. Cummings, Ronald G. Thomas, Ana S. Lukic, Randolph D. Andrews, Babak Tousi, and Dawn C. Matthews

Subjects
Rasagiline, medicine.medical_specialty, business.industry, medicine.disease, Placebo, Institutional review board, law.invention, Clinical trial, chemistry.chemical_compound, Randomized controlled trial, chemistry, Quality of life, law, medicine, Clinical endpoint, Dementia, Psychiatry, business
Abstract

Background: A Phase II proof of concept (POC) randomized clinical trial was conducted to evaluate the effects of rasagiline, a MAO-B inhibitor, in mild to moderate Alzheimer’s disease. The primary objective was to determine if 1 mg of rasagiline daily for 24 weeks is associated with improved regional brain metabolism (FDG PET) compared to placebo. Secondary objectives included use of flortaucipir PET to assess effects on tau pathology and determination of directional consistency of clinical endpoints with FDG PET. Methods: This was a double-blind, parallel group, placebo-controlled, community-based, three-site trial of 50 participants randomized 1:1 to receive oral rasagiline or placebo (NCT02359552). FDG PET was analyzed at screening for the presence of an AD-like pattern as an inclusion criterion and longitudinally using prespecified regions of interest and image classification. Participants who completed baseline and 24-week FDG PET scans and passed quality control were included in the primary analysis; secondary clinical outcomes were analyzed using an ITT model. Findings: Between May 19, 2015 and January 26, 2018, 96 participants were screened, 50 randomized, and 43 completed treatment. The study met its primary endpoint, demonstrating favorable change in FDG PET differences in rasagiline vs. placebo in middle frontal (2·5%,95%CI 0·3–4·7%,p

Published
2020

18. FDG PET Parkinson’s disease-related pattern as a biomarker for clinical trials in early stage disease

Author

Miles N. Wernick, Nir Giladi, Einat Even-Sapir, Stephen C. Strother, Dawn C. Matthews, Ana S. Lukic, Hedva Lerman, Randolph D. Andrews, Anat Mirelman, Jesse M. Cedarbaum, and Karleyton C. Evans

Subjects
0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Parkinson's disease, Cognitive Neuroscience, Disease, lcsh:Computer applications to medicine. Medical informatics, PDRP, Classifier, Motor symptoms, lcsh:RC346-429, Fluorodeoxyglucose positron emission tomography, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Fluorodeoxyglucose F18, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Parkinson, lcsh:Neurology. Diseases of the nervous system, Aged, Aged, 80 and over, Clinical Trials as Topic, business.industry, Therapeutic effect, Regular Article, Parkinson Disease, Biomarker, Middle Aged, medicine.disease, Clinical trial, 030104 developmental biology, Neurology, Positron-Emission Tomography, Cohort, Multivariate Analysis, FDG PET, Disease Progression, lcsh:R858-859.7, Female, Neurology (clinical), Early stage disease, business, 030217 neurology & neurosurgery
Abstract

Background The development of therapeutic interventions for Parkinson disease (PD) is challenged by disease complexity and subjectivity of symptom evaluation. A Parkinson's Disease Related Pattern (PDRP) of glucose metabolism via fluorodeoxyglucose positron emission tomography (FDG-PET) has been reported to correlate with motor symptom scores and may aid the detection of disease-modifying therapeutic effects. Objectives We sought to independently evaluate the potential utility of the PDRP as a biomarker for clinical trials of early-stage PD. Methods Two machine learning approaches (Scaled Subprofile Model (SSM) and NPAIRS with Canonical Variates Analysis) were performed on FDG-PET scans from 17 healthy controls (HC) and 23 PD patients. The approaches were compared regarding discrimination of HC from PD and relationship to motor symptoms. Results Both classifiers discriminated HC from PD (p, Graphical abstract Unlabelled Image, Highlights • The Parkinson's disease-related pattern (PDRP) of glucose metabolic effects is demonstrated in an independent cohort of early stage PD patients. • The PDRP pattern of metabolic changes is robust to variations in image processing and choice of classification model. • Age-related metabolic changes show partial overlap with the PDRP, suggesting that age-adjustment is an important consideration. • The PDRP correlates with motor function as defined by Hoehn & Yahr stage and UPDRS score. • An additional data driven metabolic classifier highlights pattern aspects associated with early stage motor decline.

Published
2018

19. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)

Author

William C. Mobley, Dawn C. Matthews, Miles N. Wernick, James B. Brewer, Robert A. Rissman, Michael S. Rafii, Ana S. Lukic, Seth Ness, Craig Pennington, Randolph D. Andrews, and Stephen C. Strother

Subjects
Adult, Male, 0301 basic medicine, Amyloid, Down syndrome, Pathology, medicine.medical_specialty, Population, tau Proteins, Cohort Studies, 03 medical and health sciences, Apolipoproteins E, 0302 clinical medicine, Atrophy, Fluorodeoxyglucose F18, Cerebellum, mental disorders, medicine, Humans, Dementia, Cognitive decline, education, Proportional Hazards Models, education.field_of_study, business.industry, General Neuroscience, Neurodegeneration, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Positron-Emission Tomography, Biomarker (medicine), Female, Down Syndrome, Geriatrics and Gerontology, Cognition Disorders, business, 030217 neurology & neurosurgery
Abstract

Background Adults with Down syndrome (DS) represent an enriched population for the development of Alzheimer's disease (AD), which could aid the study of therapeutic interventions, and in turn, could benefit from discoveries made in other AD populations. Objectives 1) Understand the relationship between tau pathology and age, amyloid deposition, neurodegeneration (MRI and FDG PET), and cognitive and functional performance; 2) detect and differentiate AD-specific changes from DS-specific brain changes in longitudinal MRI. Methods Twelve non-demented adults, ages 30 to 60, with DS were enrolled in the Down Syndrome Biomarker Initiative (DSBI), a 3-year, observational, cohort study to demonstrate the feasibility of conducting AD intervention/prevention trials in adults with DS. We collected imaging data with 18F-AV-1451 tau PET, AV-45 amyloid PET, FDG PET, and volumetric MRI, as well as cognitive and functional measures and additional laboratory measures. Results All amyloid negative subjects imaged were tau-negative. Among the amyloid positive subjects, three had tau in regions associated with Braak stage VI, two at stage V, and one at stage II. Amyloid and tau burden correlated with age. The MRI analysis produced two distinct volumetric patterns. The first differentiated DS from normal (NL) and AD, did not correlate with age or amyloid, and was longitudinally stable. The second pattern reflected AD-like atrophy and differentiated NL from AD. Tau PET and MRI atrophy correlated with several cognitive and functional measures. Conclusions Tau accumulation is associated with amyloid positivity and age, as well as with progressive neurodegeneration measurable using FDG and MRI. Tau correlates with cognitive decline, as do AD-specific hypometabolism and atrophy.

Published
2017

20. Neutron-rich fragments produced by in-flight fission of U-238

Author

K. Sümmerer, Andreas Martin Heinz, J. L. Rodriguez-Sanchez, Kerttuli Helariutta, D. Pérez-Loureiro, M. Staniou, L. Pienkowski, A. Trzcińska, J. Díaz-Cortes, M. Gascon, J. Taieb, V. Föhr, K. Subotic, Enrique Casarejos, J. Benlliure, W. Gawlikowicz, K.-H. Schmidt, S. Lukic, B. Blank, Fernando Montes, H. Alvarez-Pol, D. Dragosavac, A. Kelic-Heil, and Department of Chemistry

Subjects
Physics, COLLISIONS, Isotope, 010308 nuclear & particles physics, Fission, Projectile, Nuclear Theory, 116 Chemical sciences, Separator (oil production), 01 natural sciences, 114 Physical sciences, CROSS-SECTIONS, Nuclear physics, MODEL, YIELDS, 0103 physical sciences, Coulomb, RESIDUES, ISOTOPES, Neutron, PROJECTILE-FISSION, 010306 general physics, Nuclear Experiment, NUCLEUS
Abstract

The production cross sections of neutron-rich fission residues in reactions induced by U238 projectiles at 950A MeV impinging on Pb and Be targets are investigated at the Fragment Separator at GSI. These two targets allow us to investigate fission processes induced by two reaction mechanisms, Coulomb and nuclear excitations, and to study the role of these mechanisms in the neutron excess of the final fragments. © 2019 American Physical Society.

Published
2019

21. Systematic Investigation of Nucleon Knockout around $^{132}$Sn

Author

J. L. Rodriguez-Sanchez, M. Staniou, L. Pienkowski, J. Díaz-Cortes, V. Föhr, J. Taieb, Enrique Casarejos, D. Cortina-Gil, Thomas Aumann, S. Lukic, Fernando Montes, J. Benlliure, Andreas Martin Heinz, K. Subotic, D. Dragosavac, K. H. Schmidt, A. Kelic-Heil, A. Trzcińska, W. Gawlikowicz, H. Alvarez-Pol, A. Gargano, Kerttuli Helariutta, B. Blank, M. Gascón, Carlos A. Bertulani, D. Pérez-Loureiro, K. Sümmerer, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Physics, Tracers in Molecular Imaging (TRIM), Department of Chemistry, and Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear physics, Physics, 010308 nuclear & particles physics, 0103 physical sciences, education, Nuclear Theory, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010306 general physics, Nucleon, Nuclear Experiment, 01 natural sciences, 114 Physical sciences
Abstract

International audience; Neutron- and proton-removal cross sections for nuclei around ^132Sn have been systematically measured. The measurements clearly show the effect of the N = 82 closed shells. Model calculations describing all processes leading to single nucleon removal residual nuclei provide a reasonable description of the neutron removal process but clearly overestimate the proton removal ones. This overestimation of the proton removal channels could be explained as due to the presence of short-range correlated neutron-proton pairs in nuclei.

Published
2018

22. Systematic reduction of the proton-removal cross section in neutron-rich medium-mass nuclei

Author

Andreas Martin Heinz, K.-H. Schmidt, B. Blank, M. Staniou, J. Benlliure, A. Kelic-Heil, K. Helariutta, W. Gawlikowicz, Enrique Casarejos, J. L. Rodriguez-Sanchez, Thomas Aumann, L. Pienkowski, K. Sümmerer, J. Díaz-Cortes, D. Cortina-Gil, M. Gascon, A. Gargano, Carlos A. Bertulani, H. Alvarez-Pol, A. Trzcińska, S. Lukic, D. Dragosavac, Fernando Montes, J. Taieb, V. Föhr, D. Pérez-Loureiro, K. Subotic, Materials Physics, Tracers in Molecular Imaging (TRIM), Department of Chemistry, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
inorganic chemicals, Nuclear and High Energy Physics, Nuclear Theory, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 114 Physical sciences, 01 natural sciences, Nuclear Theory (nucl-th), Nuclear physics, Medium-mass neutron-rich nuclei, 0103 physical sciences, ddc:530, Neutron, Nuclear Experiment (nucl-ex), Nuclear Experiment, 010306 general physics, Short-range correlations, Nuclear theory, Physics, 010308 nuclear & particles physics, technology, industry, and agriculture, 115 Astronomy, Space science, lcsh:QC1-999, Nucleon removal, 3. Good health, biological sciences, Physics::Accelerator Physics, lipids (amino acids, peptides, and proteins), Nucleon, lcsh:Physics
Abstract

Single-neutron and single-proton removal cross sections have been measured for medium-mass neutron-rich nuclei around Z=50 and energies around 1000A MeV using the FRagment Separator (FRS) at GSI. The measured cross sections confirm the relative low values of the proton-removal cross sections, observed since a long time ago and not yet understood. Model calculations considering the knock-out process together with initial- and final-state interactions describe the measured neutron-removal cross sections. Proton-removal cross sections are, however, significantly over-predicted by the same calculations. The observed difference can be explained to a large extent by the knock-out of short-range correlated nucleons from dominant neutron-proton pairs in neutron-rich nuclei.

Published
2020

23. Dissociation of Down syndrome and Alzheimer's disease effects with imaging

Author

Miles N. Wernick, Seth Ness, Dawn C. Matthews, Ana S. Lukic, Robert A. Rissman, Lisa Mosconi, James B. Brewer, Michael S. Rafii, Randolph D. Andrews, Boris Marendic, Stephen C. Strother, Mark E. Schmidt, and William C. Mobley

Subjects
0301 basic medicine, Oncology, Amyloid, medicine.medical_specialty, Pathology, Down syndrome, NPAIRS, FDG, Population, Disease, Classifier, Imaging, 03 medical and health sciences, Clinical trials, 0302 clinical medicine, Neuroimaging, Internal medicine, medicine, Dementia, AV-45, education, Biomarker initiative, Glucose metabolism, education.field_of_study, medicine.diagnostic_test, Magnetic resonance imaging, Featured Article, Alzheimer's, medicine.disease, DSBI, 3. Good health, Psychiatry and Mental health, PET, 030104 developmental biology, Prodromal, Neurology (clinical), Alzheimer's disease, Psychology, 030217 neurology & neurosurgery, MRI
Abstract

IntroductionDown Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of therapeutic intervention, it is necessary to dissociate the contributions of DS and AD from overall phenotype. Imaging biomarkers offer the potential to characterize and stratify patients who will worsen clinically but have yielded mixed findings in DS subjects.MethodsWe evaluated 18F fluorodeoxyglucose positron emission tomography (PET), florbetapir PET, and structural magnetic resonance (sMR) image data from 12 nondemented DS adults using advanced multivariate machine learning methods.ResultsOur results showed distinctive patterns of glucose metabolism and brain volume enabling dissociation of DS and AD effects. AD-like pattern expression corresponded to amyloid burden and clinical measures.DiscussionThese findings lay groundwork to enable AD clinical trials with characterization and disease-specific tracking of DS adults.

Published
2016

24. O4‐09‐06: MRI, FDG, AND EARLY FRAME AMYLOID IMAGE CLASSIFIERS TO CHARACTERIZE AND DIFFERENTIATE ALZHEIMER'S DISEASE VARIANTS AND NON‐AD DEMENTIAS

Author

Randolph D. Andrews, Ucsf Aging, Dawn C. Matthews, Ana S. Lukic, Gil D. Rabinovici, and Viktoriya Bourakova

Subjects
Amyloid, Epidemiology, business.industry, Health Policy, Frame (networking), Disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, 030220 oncology & carcinogenesis, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience
Published
2018

25. P1‐380: MRI CLASSIFIERS CHARACTERIZE MILD TRAUMATIC BRAIN INJURY IN SYMPTOMATIC AND PRESYMPTOMATIC STAGES AND DIFFERENTIATE FROM ALZHEIMER'S DISEASE–RELATED IMPAIRMENT

Author

Dawn C. Matthews, Alzheimer’s Disease Neuroimaging Initiative, Virendra Mishra, Charles Bernick, Jeffrey L. Cummings, Ana S. Lukic, Sarah J. Banks, and Randolph D. Andrews

Subjects
Pathology, medicine.medical_specialty, Epidemiology, Traumatic brain injury, business.industry, Health Policy, Disease, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2018

27. Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer’s: A Multi-Modality Brain Imaging Study

Author

John D. Murray, Schantel Williams, Dawn C. Matthews, Randolph D. Andrews, Yi Li, Lisa Mosconi, Ana S. Lukic, Wai H. Tsui, Michelle Davies, Mony J. de Leon, Shankar Vallabhajosula, and Pauline McHugh

Subjects
Oncology, Apolipoprotein E, Amyloid, medicine.medical_specialty, Mediterranean diet, Disease, Article, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Glucose Metabolism, Neuroimaging, Internal medicine, Early Detection, medicine, Alzheimer’s Disease, Family history, Brain Aging, 030304 developmental biology, 0303 health sciences, Mediterranean Diet, Physical activity, business.industry, Neuropsychology, General Medicine, PET Imaging, medicine.disease, 3. Good health, Biomarker (medicine), business, 030217 neurology & neurosurgery, MRI
Abstract

Increased physical activity and higher adherence to a Mediterranean-type diet (MeDi) have been independently associated with reduced risk of Alzheimer’s disease (AD). Their association has not been investigated with the use of biomarkers. This study examines whether, among cognitively normal (NL) individuals, those who are less physically active and show lower MeDi adherence have brain biomarker abnormalities consistent with AD. Methods Forty-five NL individuals (age 54 ± 11, 71% women) with complete leisure time physical activity (LTA), dietary information, and cross-sectional 3D T1-weigthed MRI, 11C-Pittsburgh Compound B (PiB) and 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scans were examined. Voxel-wise multivariate partial least square (PLS) regression was used to examine the effects of LTA, MeDi and their interaction on brain biomarkers. Age, gender, ethnicity, education, caloric intake, BMI, family history of AD, Apolipoprotein E (APOE) genotype, presence of hypertension and insulin resistance were examined as confounds. Subjects were dichotomized into more and less physically active (LTA+ vs. LTA−; n = 21 vs. 24), and into higher vs. lower MeDi adherence groups (n = 18 vs. 27) using published scoring methods. Spatial patterns of brain biomarkers that represented the optimal association between the images and the groups were generated for all modalities using voxel-wise multivariate Partial Least Squares (PLS) regression. Results Groups were comparable for clinical and neuropsychological measures. Independent effects of LTA and MeDi factors were observed in AD-vulnerable brain regions for all modalities (p < 0.001). Increased AD-burden (in particular higher Aβ load and lower glucose metabolism) were observed in LTA− compared to LTA+ subjects, and in MeDi− as compared to MeDi+ subjects. A gradient effect was observed for all modalities so that LTA−/MeDi− subjects had the highest and LTA+/MeDi+ subjects had the lowest AD-burden (p < 0.001), although the LTA × MeDi interaction was significant only for FDG measures (p < 0.03). Adjusting for covariates did not attenuate these relationships. Conclusion Lower physical activity and MeDi adherence were associated with increased brain AD-burden among NL individuals, indicating that lifestyle factors may modulate AD risk. Studies with larger samples and longitudinal evaluations are needed to determine the predictive power of the observed associations

Published
2014

28. Analysis of a Mn–Zn Ferrite Bundle EMI Suppressor Using Different Suppressing Principles and Configurations

Author

Nelu Blaz, Ljiljana Zivanov, Obrad S. Aleksic, Maria Vesna Nikolić, Miloljub D. Lukovic, and Lazar S. Lukic

Subjects
010302 applied physics, Materials science, business.industry, Ferrite bead, 020208 electrical & electronic engineering, 02 engineering and technology, 01 natural sciences, Electromagnetic interference, Electronic, Optical and Magnetic Materials, Nuclear magnetic resonance, EMI, Bundle, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Optoelectronics, Ferrite (magnet), Electromagnetic coupling, Electrical and Electronic Engineering, business, Electrical impedance, Electronic circuit
Abstract

A novel round cable electromagnetic interference (EMI) suppressor comprising a bundle of Mn-Zn ferrite tubes was realized using different principles of suppressing, such as direct suppressing, inverting/suppressing, transform/inverting suppressing, and transform/short circuited secondary suppressing. Different primary to secondary configurations were realized for each suppressing principle and characterized in the EMI frequency region. The results obtained for different bundle configurations were compared with known commercial round cable ferrite suppressors and the initial bundle configuration made of a half turn wire through the central ferrite tube of the bundle. The results obtained for different principles and configurations were correlated in order to optimize the electromagnetic coupling between primary and secondary circuits. The values such as maximums of impedance Zm, frequency of maximum impedance Fm and suppressing range Δf around Fm calculated on 0.707 Zm were defined as the main parameters for each configuration. Certain correlations were noticed between impedance Zm and frequency Fm changes. Finally, the realized configurations were considered as devices suitable for EMI suppressing applications.

Published
2013

29. P3‐250: Measurement of Amyloid Burden Using the Early Frames of Amyloid PET and a Multivariate Classifier

Author

Miles N. Wernick, Alzheimer’s Disease Neuroimaging Initiative, Ana S. Lukic, Stephen C. Strother, Mark E. Schmidt, Randolph D. Andrews, and Dawn C. Matthews

Subjects
Multivariate statistics, Epidemiology, business.industry, Health Policy, Amyloid pet, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Amyloid burden, Neurology (clinical), Geriatrics and Gerontology, business, Classifier (UML), Neuroscience
Published
2016

30. P4‐170: Combining Neurodegenerative Characterization With Amyloid Burden Measurement Using an Early Frame Amyloid PET Multivariate Classifier

Author

Randolph D. Andrews, Mark E. Schmidt, Miles N. Wernick, Dawn C. Matthews, Stephen C. Strother, and Ana S. Lukic

Subjects
Multivariate statistics, Epidemiology, business.industry, Health Policy, Amyloid pet, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Amyloid burden, Neurology (clinical), Geriatrics and Gerontology, business, Classifier (UML), Neuroscience
Published
2016

31. P4‐346: Relationships Between TAU Burden Measured Using AV1451 PET, Regional Cerebral Glucose Metabolism, and Cognitive Status

Author

Stephen C. Strother, Dawn C. Matthews, Randolph D. Andrews, Midori Yokoyama, Ana S. Lukic, Boris Marendic, and Miles N. Wernick

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Cerebral glucose metabolism, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Internal medicine, medicine, Cognitive status, Neurology (clinical), Geriatrics and Gerontology, business
Published
2016

32. Neutron-induced fission cross section of U-234 measured at the CERN n_TOF facility

Author

D. Karadimos, R. Vlastou, K. Ioannidis, P. Demetriou, M. Diakaki, V. Vlachoudis, P. Pavlopoulos, V. Konovalov, U. Abbondanno, G. Aerts, H. Alvarez, F. Alvarez Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulos, L. Audouin, G. Badurek, P. Baumann, F. Becvar, E. Berthoumieux, F. Calvino, D. Cano Ott, R. Capote, A. C. de, V. Chepel, E. Chiaveri, N. Colonna, G. Cortes, A. Couture, J. Cox, S. David, R. Dolfini, C. Domingo Pardo, A. Dorochenko, W. Dridi, I. Duran, C. Eleftheriadis, M. Embid Segura, L. Ferrant, A. Ferrari, R. Ferreira Marques, L. Fitzpatrick, H. Frais Koelbl, K. Fuji, W. Furman, I. Goncalves, R. Gallino, P. Cennini, E. Gonzalez Romero, A. Goverdovski, F. Gramegna, E. Griesmayer, C. Guerrero, F. Gunsing, B. Haas, R. Haight, M. Heil, A. Herrera Martinez, M. Igashira, S. Isaev, E. Jericha, Y. Kadi, F. Kaeppeler, D. Karamanis, M. Kerveno, V. Ketlerov, P. Koehler, D. Kolokolov, M. Krticka, C. Lamboudis, H. Leeb, A. Lindote, I. Lopes, M. Lozano, S. Lukic, J. Marganiec, L. Marques, S. Marrone, P. Mastinu, A. Mengoni, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neves, H. Oberhummer, S. O'Brien, M. Oshima, J. Pancin, C. Papadopoulos, C. Paradela, N. Patronis, A. Pavlik, L. Perrot, R. Plag, A. Plompen, A. Plukis, A. Poch, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, M. Rosetti, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, L. Sarchiapone, I. Savvidis, M. Sedysheva, K. Stamoulis, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan Got, L. Tavora, R. Terlizzi, A. Tsinganis, P. Vaz, A. Ventura, D. Villamarin, M. C. Vincente, F. Voss, H. Wendler, M. Wiescher, K. Wisshak, MASSIMI, CRISTIAN, VANNINI, GIANNI, D. Karadimo, R. Vlastou, K. Ioannidi, P. Demetriou, M. Diakaki, V. Vlachoudi, P. Pavlopoulo, V. Konovalov, U. Abbondanno, G. Aert, H. Alvarez, F. Alvarez-Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulo, L. Audouin, G. Badurek, P. Baumann, F. Becvar, E. Berthoumieux, F. Calvino, D. Cano-Ott, R. Capote, A. C. de, V. Chepel, E. Chiaveri, N. Colonna, G. Corte, A. Couture, J. Cox, S. David, R. Dolfini, C. Domingo-Pardo, A. Dorochenko, W. Dridi, I. Duran, C. Eleftheriadi, M. Embid-Segura, L. Ferrant, A. Ferrari, R. Ferreira-Marque, L. Fitzpatrick, H. Frais-Koelbl, K. Fuji, W. Furman, I. Goncalve, R. Gallino, P. Cennini, E. Gonzalez-Romero, A. Goverdovski, F. Gramegna, E. Griesmayer, C. Guerrero, F. Gunsing, B. Haa, R. Haight, M. Heil, A. Herrera-Martinez, M. Igashira, S. Isaev, E. Jericha, Y. Kadi, F. Kaeppeler, D. Karamani, M. Kerveno, V. Ketlerov, P. Koehler, D. Kolokolov, M. Krticka, C. Lamboudi, H. Leeb, A. Lindote, I. Lope, M. Lozano, S. Lukic, J. Marganiec, L. Marque, S. Marrone, C. Massimi, P. Mastinu, A. Mengoni, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neve, H. Oberhummer, S. O'Brien, M. Oshima, J. Pancin, C. Papadopoulo, C. Paradela, N. Patroni, A. Pavlik, L. Perrot, R. Plag, A. Plompen, A. Pluki, A. Poch, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, M. Rosetti, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, L. Sarchiapone, I. Savvidi, M. Sedysheva, K. Stamouli, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan-Got, L. Tavora, R. Terlizzi, A. Tsingani, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, M. C. Vincente, F. Vo, H. Wendler, M. Wiescher, and K. Wisshak

Subjects
MINOR ACTINIDES TRANSMUTATIONS, Nuclear Experiment, NEUTRON TIME OF FLIGHT, NEUTRON INDUCED FISSION
Abstract

The neutron-induced fission cross section of U234 has been measured at the CERN n_TOF facility relative to the standard fission cross section of U235 from 20 keV to 1.4 MeV and of U238 from 1.4 to 200 MeV. A fast ionization chamber (FIC) was used as a fission fragment detector with a detection efficiency of no less than 97%. The high instantaneous flux and the low background characterizing the n_TOF facility resulted in wide-energy-range data (0.02 to 200 MeV), with high energy resolution, high statistics, and systematic uncertainties bellow 3%. Previous investigations around the energy of the fission threshold revealed structures attributed to β-vibrational levels, which have been confirmed by the present measurements. Theoretical calculations have been performed, employing the talys code with model parameters tuned to fairly reproduce the experimental data.

Published
2014

33. Measurement and analysis of the Am-243 neutron capture cross section at the n_TOF facility at CERN

Author

E. Mendoza, D. Cano Ott, C. Guerrero, E. Berthoumieux, U. Abbondanno, G. Aerts, F. Alvarez Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulos, L. Audouin, G. Badurek, J. Balibrea, P. Baumann, F. Becvar, F. Belloni, F. Calvino, M. Calviani, R. Capote, C. Carrapico, A. C. de, P. Cennini, V. Chepel, E. Chiaveri, N. Colonna, G. Cortes, A. Couture, J. Cox, M. Dahlfors, S. David, I. Dillmann, R. Dolfini, C. Domingo Pardo, W. Dridi, I. Duran, C. Eleftheriadis, L. Ferrant, A. Ferrari, R. Ferreira Marques, L. Fitzpatrick, H. Frais Koelbl, K. Fujii, W. Furman, I. Goncalves, E. Gonzalez Romero, A. Goverdovski, F. Gramegna, E. Griesmayer, F. Gunsing, B. Haas, R. Haight, M. Heil, A. Herrera Martinez, M. Igashira, S. Isaev, E. Jericha, F. Kaeppeler, Y. Kadi, D. Karadimos, D. Karamanis, V. Ketlerov, M. Kerveno, P. Koehler, V. Konovalov, E. Kossionides, M. Krticka, C. Lampoudis, H. Leeb, A. Lindote, S. L. Meo, I. Lopes, R. Lossito, M. Lozano, S. Lukic, J. Marganiec, L. Marques, S. Marrone, T. Martinez, MASSIMI, CRISTIAN, P. Mastinu, A. Mengoni, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neves, H. Oberhummer, S. O'Brien, M. Oshima, J. Pancin, C. Papachristodoulou, C. Papadopoulos, C. Paradela, N. Patronis, A. Pavlik, P. Pavlopoulos, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Plukis, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, C. Santos, L. Sarchiapone, I. Savvidis, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan Got, L. Tavora, R. Terlizzi, VANNINI, GIANNI, P. Vaz, A. Ventura, D. Villamarin, M. C. Vicente, V. Vlachoudis, R. Vlastou, F. Voss, S. Walter, H. Wendler, M. Wiescher, K. Wisshak, E. Mendoza, D. Cano-Ott, C. Guerrero, E. Berthoumieux, U. Abbondanno, G. Aert, F. Alvarez-Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulo, L. Audouin, G. Badurek, J. Balibrea, P. Baumann, F. Becvar, F. Belloni, F. Calvino, M. Calviani, R. Capote, C. Carrapico, A. C. de, P. Cennini, V. Chepel, E. Chiaveri, N. Colonna, G. Corte, A. Couture, J. Cox, M. Dahlfor, S. David, I. Dillmann, R. Dolfini, C. Domingo-Pardo, W. Dridi, I. Duran, C. Eleftheriadi, L. Ferrant, A. Ferrari, R. Ferreira-Marque, L. Fitzpatrick, H. Frais-Koelbl, K. Fujii, W. Furman, I. Goncalve, E. Gonzalez-Romero, A. Goverdovski, F. Gramegna, E. Griesmayer, F. Gunsing, B. Haa, R. Haight, M. Heil, A. Herrera-Martinez, M. Igashira, S. Isaev, E. Jericha, F. Kaeppeler, Y. Kadi, D. Karadimo, D. Karamani, V. Ketlerov, M. Kerveno, P. Koehler, V. Konovalov, E. Kossionide, M. Krticka, C. Lampoudi, H. Leeb, A. Lindote, S. L. Meo, I. Lope, R. Lossito, M. Lozano, S. Lukic, J. Marganiec, L. Marque, S. Marrone, T. Martinez, C. Massimi, P. Mastinu, A. Mengoni, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neve, H. Oberhummer, S. O'Brien, M. Oshima, J. Pancin, C. Papachristodoulou, C. Papadopoulo, C. Paradela, N. Patroni, A. Pavlik, P. Pavlopoulo, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Pluki, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, C. Santo, L. Sarchiapone, I. Savvidi, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan-Got, L. Tavora, R. Terlizzi, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, M. C. Vicente, V. Vlachoudi, R. Vlastou, F. Vo, S. Walter, H. Wendler, M. Wiescher, and K. Wisshak

Subjects
RADIATIVE NEUTRON CAPTURE, NEUTRON TIME OF FLIGHT
Abstract

Background: The design of new nuclear reactors and transmutation devices requires to reduce the present neutron cross section uncertainties of minor actinides. Purpose: Improvement of the Am243(n,γ) cross section uncertainty. Method: The Am243(n,γ) cross section has been measured at the n-TOF facility at CERN with a BaF2 total absorption calorimeter, in the energy range between 0.7 eV and 2.5 keV. Results: The Am243(n,γ) cross section has been successfully measured in the mentioned energy range. The resolved resonance region has been extended from 250 eV up to 400 eV. In the unresolved resonance region our results are compatible with one of the two incompatible capture data sets available below 2.5 keV. The data available in EXFOR and in the literature have been used to perform a simple analysis above 2.5 keV. Conclusions: The results of this measurement contribute to reduce the Am243(n,γ) cross section uncertainty and suggest that this cross section is underestimated up to 25% in the neutron energy range between 50 eV and a few keV in the present evaluated data libraries. Background: The design of new nuclear reactors and transmutation devices requires to reduce the present neutron cross section uncertainties of minor actinides. Purpose: Improvement of the Am243(n,γ) cross section uncertainty. Method: The Am243(n,γ) cross section has been measured at the n-TOF facility at CERN with a BaF2 total absorption calorimeter, in the energy range between 0.7 eV and 2.5 keV. Results: The Am243(n,γ) cross section has been successfully measured in the mentioned energy range. The resolved resonance region has been extended from 250 eV up to 400 eV. In the unresolved resonance region our results are compatible with one of the two incompatible capture data sets available below 2.5 keV. The data available in EXFOR and in the literature have been used to perform a simple analysis above 2.5 keV. Conclusions: The results of this measurement contribute to reduce the Am243(n,γ) cross section uncertainty and suggest that this cross section is underestimated up to 25% in the neutron energy range between 50 eV and a few keV in the present evaluated data libraries.

Published
2014

34. Neutron-induced fission cross section ofNp237in the keV to MeV range at the CERN n_TOF facility

Author

L. Sarchiapone, S. Andriamonje, G. Cortes, J. Marganiec, R. C. Haight, P. E. Koehler, H. Álvarez, Masayuki Igashira, K. Ioannidis, M. Oshima, C. Lamboudis, J. L. Tain, C. Paradela, E. Chiaveri, P. F. Mastinu, A. Dorochenko, J. Andrzejewski, G. Aerts, J. Cox, A. J. M. Plompen, Isabel Lopes, B. Haas, Matthias Heil, J. Pancin, E. Skordis, L. Audouin, F. Voss, P. Cennini, S. David, Roberto Capote, P.A. Assimakopoulos, Thomas Rauscher, F. Neves, P. M. Milazzo, A. Tsinganis, Y. Kadi, G. Tagliente, I. Duran, H. Frais-Koelbl, Carlos Guerrero, U. Abbondanno, M. Mosconi, P. Pavlopoulos, D. Karadimos, Nicola Colonna, C. Rubbia, M. Kokkoris, Michael Wiescher, V. Konovalov, F. Bečvář, Heinz Oberhummer, S. O'Brien, E. González-Romero, Isabel S. Gonçalves, K. C. Stamoulis, S. Marrone, W. Dridi, I. Savvidis, J. Salgado, D. Cano-Ott, Marco Calviani, M. Diakaki, A. Poch, Vasilis Vlachoudis, A. Lindote, M. Sedysheva, R. Terlizzi, A. Goverdovski, M. Kerveno, Rene Reifarth, E. Griesmayer, V. Ketlerov, A. Plukis, F. Alvarez-Velarde, A. Carrillo de Albornoz, C. Papadopoulos, M. Embid-Segura, L. Ferrant, L. Tavora, K. Fuji, Gerald Badurek, F. Käppeler, Paraskevi Demetriou, L. Fitzpatrick, F. Gramegna, Ralf Plag, R. Dolfini, A. Pavlik, J. M. Quesada, C. Eleftheriadis, M. Rosetti, C. Pretel, Manuel Lozano, C. Domingo-Pardo, L. Tassan-Got, M. C. Vincente, D. Villamarin, P. Rullhusen, M. Krtička, F. Calviño, W.I. Furman, L. Perrot, Corrie S. Moreau, R. Ferreira-Marques, S. Lukic, V. Chepel, A. Herrera-Martinez, N. Patronis, G. Rudolf, L. Marques, P. Vaz, Arnaud Ferrari, Aaron Couture, P. Baumann, Alberto Mengoni, S. Isaev, A. Ventura, R. Vlastou, E. Berthoumieux, G. Vannini, R. Gallino, K. Wisshak, D. Karamanis, H. Wendler, D. Kolokolov, H. Leeb, C. Stephan, F. Gunsing, Cristian Massimi, and E. Jericha

Subjects
Physics, Large Hadron Collider, 010308 nuclear & particles physics, Fission, Model parameters, 7. Clean energy, 01 natural sciences, Nuclear physics, 0103 physical sciences, Homogeneity (physics), Ionization chamber, Neutron cross section, Neutron, Atomic physics, Nuclear Experiment, 010306 general physics, Spectroscopy
Abstract

The neutron-induced fission cross section of Np237 was experimentally determined at the high-resolution and high-intensity facility n-TOF, at CERN, in the energy range 100 keV to 9 MeV, using the U235(n,f) and U238(n,f) cross section standards below and above 2 MeV, respectively. A fast ionization chamber was used in order to detect the fission fragments from the reactions and the targets were characterized as far as their mass and homogeneity are concerned by means of α spectroscopy and Rutherford backscattering spectroscopy respectively. Theoretical calculations within the Hauser-Feshbach formalism have been performed, employing the empire code, and the model parameters were tuned in order to successfully reproduce the experimental fission cross-sectional data and simultaneously all the competing reaction channels.

Published
2016

35. Multispectral Diagnostic Imaging of the Iris in Pigment Dispersion Syndrome

Author

Daniel K. Roberts, Ana S. Lukic, Jacob T. Wilensky, Yongyi Yang, and Miles N. Wernick

Subjects
Adult, Diagnostic Imaging, Male, genetic structures, Multispectral image, Iris recognition, Iris, Exfoliation Syndrome, White People, Article, Optics, Region of interest, medicine, Humans, Iris (anatomy), Aged, Spectroscopy, Near-Infrared, Eye Color, business.industry, Near-infrared spectroscopy, Middle Aged, medicine.disease, Black or African American, Ophthalmology, Wavelength, medicine.anatomical_structure, Iris transillumination defect, Pigment dispersion syndrome, Female, sense organs, business
Abstract

PURPOSE To determine if wavelength selection with near infrared iris imaging may enhance iris transillumination defects (ITDs) in pigment dispersion syndrome. METHODS An experimental apparatus was used to acquire iris images in 6 African-American (AA) and 6 White patients with pigment dispersion syndrome. Light-emitting diode probes of 6 different spectral bands (700 to 950 nm) were used to project light into patients' eyes. Iris patterns were photographed, ITD regions of interest were outlined, and region of interest contrasts were calculated for each spectral band. RESULTS Contrasts varied as a function of wavelength (P

Published
2012

36. 237Np(n,f) Cross Section: New Data and Present Status

Author

B. Haas, I. Savvidis, C. Lampoudis, A. Pavlik, C. Domingo-Pardo, G. Cortes, Martin Heil, P. Cennini, S. David, D. Tarrío, D. Cano-Ott, W. Dridi, Roberto Capote, P.A. Assimakopoulos, M. Mosconi, S. O'Brien, G. Tagliente, Marco Calviani, M. Oshima, R. Terlizzi, Corrie S. Moreau, S. Walter, J. Andrzejewski, L. Tavora, Ralf Plag, F. Calviño, H. Leeb, J. Salgado, Isabel Lopes, P. Rullhusen, J. Marganiec, S. Andriamonje, A. Poch, C. Santos, E. Kossionides, E. Chiaveri, K. Wisshak, P. F. Mastinu, A. J. M. Plompen, Christoph A. Stephan, J. Pancin, A. Herrera-Martinez, N. Patronis, A. Ventura, F. Gunsing, D. Trubert, L. Ferrant, Cristian Massimi, Javier Praena, I. Duran, Arnaud Ferrari, G. Aerts, M. Dahlfors, Y. Kadi, R. C. Haight, M. Embid-Segura, P. Vaz, Rene Reifarth, H. Álvarez, S. Lukic, D. Villamarin, Alberto Mengoni, James L. Cox, C. Paradela, M. C. Vicente, C. Eleftheriadis, Thomas Rauscher, Aaron Couture, M. Krtička, S. Isaev, J. M. Quesada, Manuel Lozano, L. Tassan-Got, Carlos Guerrero, U. Abbondanno, J. L. Tain, L. Audouin, B. Berthier, P. E. Koehler, L. Sarchiapone, D. Karadimos, R. Ferreira-Marques, T. Martinez, Heinz Oberhummer, E. Jericha, C. Le Naour, E. González-Romero, P. Pavlopoulos, Michael Wiescher, F. Voss, F. Becvar, W.I. Furman, F. Alvarez-Velarde, R. Vlastou, Marco T. Pigni, Nicola Colonna, Masayuki Igashira, E. Berthoumieux, Gerald Badurek, A. Plukis, Vasilis Vlachoudis, C. A. Papachristodoulou, F. Gramegna, K. Fujii, C. T. Papadopoulos, A. Lindote, C. Rubbia, C. Pretel, F. Käppeler, Isabel S. Gonçalves, S. Marrone, M. Kerveno, F. Neves, P. M. Milazzo, L. Perrot, V. Chepel, G. Rudolf, P. Baumann, G. Vannini, C. Carrapiço, D. Karamanis, I. Dillmann, Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya. GREENER - Grup de recerca d'estudis energètics i de les radiacions, Paradela C., Tassan-Got L., Audouin L., Berthier B., Ferrant L., Isaev S., Naour C. Le, Stephan C., Trubert D., David S., Duran I., Tarrio D., Alvarez H., Abbondanno U., Fujii K., Milazzo P. M., Moreau C., Aerts G., Alvarez-Velarde F., Cano-Ott D., Embid-Segura M., Gonzalez-Romero E., Guerrero C., Martinez T., Villamarin D., Vicente M. C., Andriamonje S., Berthoumieux E., Dridi W., Gunsing F., Pancin J., Perrot L., Plukis A., Andrzejewski J., Marganiec J., Assimakopoulos P., Karadimos D., Karamanis D., Papachristodoulou C., Patronis N., Badurek G., Jericha E., Leeb H., Oberhummer H., Pigni M. T., Baumann P., Kerveno M., Lukic S., Rudolf G., Becvar F., Krticka M., Calvino F., Cortes G., Poch A., Pretel C., Calviani M., Gramegna F., Mastinu P., Praena J., Capote R., Carrapico C., Cennini P., Chiaveri E., Dahlfors M., Ferrari A., Herrera-Martinez A., Kadi Y., Sarchiapone L., Vlachoudis V., Chepel V., Ferreira-Marques R., Lindote A., Lopes I., Neves F., Colonna N., Tagliente G., Terlizzi R., Couture A., Cox J., Marrone S., Obrien S., Wiescher M., Dillmann I., Heil M., Kappeler F., Mosconi M., Voss F., Walter S., Wisshak K., Domingo-Pardo C., Plag R., Plompen A., Tain J. L., Eleftheriadis C., Savvidis I., Furman W., Goncalves I., Salgado J., Santos C., Tavora L., Vaz P., Haas B., Haight R., Reifarth R., Igashira M., Koehler P., Kossionides E., Lampoudis C., Lozano M., Quesada J., Massimi C., Vannini G., Mengoni A., Oshima M., Papadopoulos C., Pavlik A., Pavlopoulos P., Vlastou R., Rauscher T., Rubbia C., Rullhusen P., Ventura A., Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Aval du cycle et Energie Nucléaire (ACEN), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Pôle Universitaire Léonard de Vinci, Pôle Universitaire Léonard de Vinci (PULV), nTOF, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Energies::Energia nuclear [Àrees temàtiques de la UPC], Physics, neutron fission cross section, Np-237, Fission, Nuclear data, General Physics and Astronomy, Nuclear energy, 020206 networking & telecommunications, Energies::Energia nuclear::Reactors nuclears de fissió [Àrees temàtiques de la UPC], 02 engineering and technology, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear physics, TIME-OF-FLIGHT, Cross section (physics), Fusion reactors, Reactors nuclears, n TOF experiment, 0202 electrical engineering, electronic engineering, information engineering, Energia nuclear, 020201 artificial intelligence & image processing, Energy (signal processing), Neutron-induced ssion reactions
Abstract

In this document, we present the nal result obtained at the n TOF experiment for the neutron- induced ssion cross section of the 237Np, from the ssion threshold up to 1 GeV. The method applied to get this result is brie y discussed. n TOF data are compared to the last experimental measurements using other TOF facilities or the surrogate method, reported experiments performed with monoenergetic sources and the FISCAL systematic, including a discussion about the existing discrepancies.

Published
2011

37. High-energy Neutron-induced Fission Cross Sections of Natural Lead and Bismuth-209

Author

D. Tarrio, L. Tassan-Got, L. Audouin, B. Berthier, L. Ferrant, S. Isaev, C. Le Naour, C. Stephan, D. Trubert, S. David, I. Duran, C. Paradela, H. Alvarez, U. Abbondanno, K. Fujii, P. M. Milazzo, C. Moreau, G. Aerts, F. Alvarez-Velarde, D. Cano-Ott, M. Embid-Segura, E. Gonzalez-Romero, C. Guerrero, T. Martinez, D. Villamarin, M. C. Vicente, S. Andriamonje, E. Berthoumieux, W. Dridi, F. Gunsig, J. Pancin, L. Perrot, A. Plukis, J. Andrzejewski, J. Marganiec, P. Assimakopoulos, D. Karadimos, D. Karamanis, C. Papachristodoulou, N. Patronis, G. Badurek, E. Jericha, H. Leeb, H. Oberhummer, M. T. Pigni, P. Baumann, M. Kerveno, S. Lukic, G. Rudolf, F. Becvar, M. Krticka, F. Calvino, G. Cortes, A. Poch, C. Pretel, M. Calviani, F. Gramegna, P. Mastinu, J. Praena, R. Capote, C. Carrapico, P. Cennini, E. Chiaveri, M. Dahlfors, A. Ferrari, I. Goncalves, A. Herrera-Martinez, Y. Kadi, L. Sarchiapone, V. Vlachoudis, V. Chepel, R. Ferreira-Marques, A. Lindote, I. Lopes, F. Neves, N. Colonna, G. Tagliente, R. Terlizzi, A. Couture, J. Cox, S. Marrone, S. O'brien, M. Wiescher, I. Dillmann, M. Heil, F. Kappeler, M. Mosconi, F. Voss, S. Walter, K. Wisshak, C. Domingo-Pardo, R. Plag, A. Plompen, J. L. Tain, C. Eleftheriadis, I. Savvidis, W. Furman, B. Haas, R. Haight, R. Reifarth, M. Igashira, P. Koehler, E. Kossionides, C. Lampoudis, M. Lozano, J. Quesada, C. Massimi, G. Vannini, A. Mengoni, M. Oshima, C. Papadopoulos, A. Pavlik, P. Pavlopoulos, R. Vlastou, T. Rauscher, C. Rubbia, P. Rullhusen, J. Salgado, C. Santos, L. Tavora, P. Vaz, A. Ventura, Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya. GREENER - Grup de recerca d'estudis energètics i de les radiacions, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Aval du cycle et Energie Nucléaire (ACEN), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Pôle Universitaire Léonard de Vinci, Pôle Universitaire Léonard de Vinci (PULV), nTOF, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Tarrno D., Tassan-Got L., Audouin L., Berthier B., Ferrant L., Isaev S., Naour C. Le, Stephan C., Trubert D., David S., Duran I., Paradela C., Alvarez H., Abbondanno U., Fujii K., Milazzo P. M., Moreau C., Aerts G., Alvarez-Velarde F., Cano-Ott D., Embid-Segura M., Gonzalez-Romero E., Guerrero C., Martinez T., Villamarin D., Vicente M. C., Andriamonje S., Berthoumieux E., Dridi W., Gunsig F., Pancin J., Perrot L., Plukis A., Andrzejewski J., Marganiec J., Assimakopoulos P., Karadimos D., Karamanis D., Papachristodoulou C., Patronis N., Badurek G., Jericha E., Leeb H., Oberhummer H., Pigni M. T., Baumann P., Kerveno M., Lukic S., Rudolf G., Becvar F., Krticka M., Calvino F., Cortes G., Poch A., Pretel C., Calviani M., Gramegna F., Mastinu P., Praena J., Capote R., Carrapico C., Cennini P., Chiaveri E., Dahlfors M., Ferrari A., Goncalves I., Herrera-Martinez A., Kadi Y., Sarchiapone L., Vlachoudis V., Chepel V., Ferreira-Marques R., Lindote A., Lopes I., Neves F., Colonna N., Tagliente G., Terlizzi R., Couture A., Cox J., Marrone S., Obrien S., Wiescher M., Dillmann I., Heil M., Kappeler F., Mosconi M., Voss F., Walter S., Wisshak K., Domingo-Pardo C., Plag R., Plompen A., Tain J. L., Eleftheriadis C., Savvidis I., Furman W., Haas B., Haight R., Reifarth R., Igashira M., Koehler P., Kossionides E., Lampoudis C., Lozano M., Quesada J., Massimi C., Vannini G., Mengoni A., Oshima M., Papadopoulos C., Pavlik A., Pavlopoulos P., Vlastou R., Rauscher T., Rubbia C., Rullhusen P., Salgado J., Santos C., Tavora L., Vaz P., and Ventura A.

Subjects
Pb-nat(n, Fission, Nuclear data, Nuclear Theory, General Physics and Astronomy, chemistry.chemical_element, f), Energies::Energia nuclear::Reactors nuclears de fissió [Àrees temàtiques de la UPC], [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, Bismuth, Nuclear physics, Nuclear reactors, Reactors nuclears, Neutron, Spallation, Nuclear Experiment, EMERGING NUCLEAR TECHNOLOGIES, Neutron-induced ssion reactions, Energies::Energia nuclear [Àrees temàtiques de la UPC], Physics, Cluster decay, Nuclear energy, Bi-209(n, n TOF facility, TIME-OF-FLIGHT, chemistry, Spallation neutron source, Energia nuclear, Neutron source, PPAC fission detector, Spallation Neutron Source
Abstract

The CERN Neutron Time-Of-Flight (n-TOF) facility is well suited to measure small neutron-induced fission cross sections, as those of subactinides. The cross section ratios of {sup nat}Pb and {sup 209}Bi relative to {sup 235}U and {sup 238}U were measured using PPAC detectors. The fragment coincidence method allows to unambiguously identify the fission events. The present experiment provides the first results for neutron-induced fission up to 1 GeV for {sup nat}Pb and {sup 209}Bi. A good agreement with previous experimental data below 200 MeV is shown. The comparison with proton-induced fission indicates that the limiting regime where neutron-induced and proton-induced fission reach equal cross section is close to 1 GeV.

Published
2011

38. Dimensionality estimation for optimal detection of functional networks in BOLD fMRI data

Author

Miles N. Wernick, Grigori Yourganov, Steven L. Small, Xu Chen, Cheryl L. Grady, Stephen C. Strother, and Ana S. Lukic

Subjects
Adult, Cognitive Neuroscience, Multivariate normal distribution, Article, 050105 experimental psychology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Image Processing, Computer-Assisted, Humans, 0501 psychology and cognitive sciences, Detection theory, Minimum description length, Aged, Mathematics, Brain Mapping, business.industry, 05 social sciences, Brain, Reproducibility of Results, Estimator, Pattern recognition, Middle Aged, Linear discriminant analysis, Magnetic Resonance Imaging, ROC Curve, Neurology, Area Under Curve, Principal component analysis, Metric (mathematics), Artificial intelligence, Nerve Net, business, Algorithms, 030217 neurology & neurosurgery, Curse of dimensionality
Abstract

Estimation of the intrinsic dimensionality of fMRI data is an important part of data analysis that helps to separate the signal of interest from noise. We have studied multiple methods of dimensionality estimation proposed in the literature and used these estimates to select a subset of principal components that was subsequently processed by linear discriminant analysis (LDA). Using simulated multivariate Gaussian data, we show that the dimensionality that optimizes signal detection (in terms of the receiver operating characteristic (ROC) metric) goes through a transition from many dimensions to a single dimension as a function of the signal-to-noise ratio. This transition happens when the loci of activation are organized into a spatial network and the variance of the networked, task-related signals is high enough for the signal to be easily detected in the data. We show that reproducibility of activation maps is a metric that captures this switch in intrinsic dimensionality. Except for reproducibility, all of the methods of dimensionality estimation we considered failed to capture this transition: optimization of Bayesian evidence, minimum description length, supervised and unsupervised LDA prediction, and Stein's unbiased risk estimator. This failure results in sub-optimal ROC performance of LDA in the presence of a spatially distributed network, and may have caused LDA to underperform in many of the reported comparisons in the literature. Using real fMRI data sets, including multi-subject group and within-subject longitudinal analysis we demonstrate the existence of these dimensionality transitions in real data.

Published
2011

39. Novel Observations and Potential Applications Using Digital Infrared Iris Imaging

Author

Miles N. Wernick, Ana S. Lukic, Yongyi Yang, Sayoko E. Moroi, Daniel K. Roberts, and Jacob T. Wilensky

Subjects
Adult, Diagnostic Imaging, Male, business.product_category, Adolescent, Infrared Rays, Microscopy, Acoustic, Article, Vascular anomaly, Cataracts, Photography, medicine, Humans, Iris (anatomy), Child, Aged, Digital camera, Aged, 80 and over, business.industry, Middle Aged, medicine.disease, Oculocutaneous albinism, medicine.anatomical_structure, Iris Diseases, Child, Preschool, Pigment dispersion syndrome, Optometry, Female, business, Pseudophakia
Abstract

Digital infrared iris photography using a modified digital camera system was performed on approximately 300 subjects seen during routine clinical care and research at one facility. Because this image database offered an opportunity to gain new insight into the potential utility of infrared iris imaging, it was surveyed for unique image patterns. Then, a selection of photographs was compiled that would illustrate the spectrum of this imaging experience. Potentially informative image patterns were observed in subjects with cataracts, diabetic retinopathy, Posner–Schlossman syndrome, iridociliary cysts, long anterior lens zonules, nevi, oculocutaneous albinism, pigment dispersion syndrome, pseudophakia, suspected vascular anomaly, and trauma. Image patterns were often unanticipated regardless of preexisting information and suggest that infrared iris imaging may have numerous potential clinical and research applications, some of which may still not be recognized. These observations suggest further development and study of this technology.

Published
2009

40. Neutron reactions and nuclear cosmo-chronology

Author

I. Goncalves, D. Karamanis, L. Ferrant, Thomas Rauscher, L. Fitzpatrick, D. Karadimos, M. Dahlfors, F. Gramegna, P. Vaz, P. Cennini, M. Rosetti, J. Cox, Rene Reifarth, M. C. Vincente, Alberto Ventura, Aaron Couture, Laurent Tassan-Got, P. M. Milazzo, V. Ketlerov, A. Pavlik, P. Pavlopoulos, Ralf Plag, J. M. Quesada, D. Villamarin, C. Lamboudis, J. L. Tain, G. Vannini, M. Oshima, F. Voss, E. Jericha, L. Sarchiapone, M. Mosconi, J. Andrzejewski, W.I. Furman, R. Gallino, Carlo Rubbia, V. Vlachoudis, Nicola Colonna, M. Embid-Segura, C. T. Papadopoulos, A. Lindote, J. Pancin, E. Griesmayer, C. Stephan, S. O'Brien, V. Konovalov, E. Chiaveri, D. Cano-Ott, K. Fujii, H. Alvarez-Pol, R. Vlastou, C. A. Papachristodoulou, R. Terlizzi, B. Haas, Michael Heil, Manuel Lozano, C. Paradela, A. Carrillo de Albornoz, F. Calviño, H. Leeb, S. Marrone, A. J. M. Plompen, I. Dillman, G. Aerts, S. Lukic, L. Tavora, Carlos Guerrero, C. Eleftheriadis, Masayuki Igashira, S. Isaev, U. Abbondanno, E. Kossionides, M. Kerveno, Heinz Oberhummer, G. Rudolf, Yacine Kadi, I. Lopes, G. Cortes, P. Rullhusen, C. Domingo Pardo, R. C. Haight, H. Frais-Koelbl, A. Herrera-Martinez, Alfredo Ferrari, R. Ferreira-Marques, Alberto Mengoni, C. Pretel, N. Patronis, W. Dridi, S. Bisterzo, K. Wisshak, L. Audouin, Roberto Capote, P.A. Assimakopoulos, Michael Wiescher, E. Berthoumieux, F. Neves, S. Walter, H. Wendler, A. Goverdovski, F. Gunsing, F. Alvarez-Velarde, I. Savvidis, Gerald Badurek, R. Dolfini, P. E. Koehler, I. Duran, V. Chepel, P. Baumann, J. Marganiec, S. Andriamonje, P. F. Mastinu, L. Perrot, F. Käppeler, M. Krtička, C. Moreau, J. Salgado, L. Marques, A. Poch, E. Gonzalez-Romero, A. Plukis, F. Bečvář, S. David, G. Tagliente, Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Pole Universitaire Leonard de Vinci, Pôle Universitaire Léonard de Vinci (PULV), nTOF, Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya. GREENER - Grup de recerca d'estudis energètics i de les radiacions, and Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
stars, Neutron capture, Nuclear and High Energy Physics, Estels -- Estructura, Inelastic scattering, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Nuclear physics, Stellar cross sections, Cross section (physics), 0103 physical sciences, Stars--Structure, Neutron cross section, Neutron, cross-sections, capture, 010303 astronomy & astrophysics, milky-way, isotopes, Physics, Neutrons, Física [Àrees temàtiques de la UPC], Re/Os cosmo-chronometer, 010308 nuclear & particles physics, stellar cross sections, nucleosynthesis, inelastic scattering, Neutron temperature, re/os cosmo-chronometer, age, 13. Climate action, r-process, Atomic physics, s-process, s process, neutron capture
Abstract

The beta-decay of Re-187 (t(1/2) = 42.3 Gyr) represents a suited cosmo-chronometer for the age of the r-process abundances, since the radiogenic part of the daughter isotope (OS)-O-187 is defined by the difference between the solar Os-187 abundance and s-process contribution to Os-187. The latter component can be determined via the s-process systematics based on the stellar neutron capture cross sections of Os-186 and Os-187. The laboratory cross section of Os-187 requires a significant correction for the effect of the low-lying excited state at 9.75 keV, which is strongly populated under stellar conditions. This theoretical correction can be improved by an experimental cross section for inelastic scattering to the 9.75 keV state. High resolution time-of-flight measurements of (n, gamma) cross sections of (OS)-O-186,187,188 from I eV to I MeV at CERN n-TOF facility are reported. The inferred stellar cross sections differ from previously recommended values. In addition, the inelastic scattering cross section has been measured at 30 keV neutron energy via time-of-flight at the Karlsruhe 3.7 MV Van de Graaff. The implications of these results for the Re/Os clock are discussed. (c) 2007 Elsevier B.V. All rights reserved. ispartof: Progress in Particle and Nuclear Physics vol:59 issue:1 pages:165-173 ispartof: location:ITALY, Erice status: published

Published
2007

41. O1‐07‐04: Neurodegenerative variability among amyloid positive MCI patients: Implications for clinical trials and clinical care

Author

Dawn C. Matthews, Midori Yokoyama, Boris Marendic, Ana S. Lukic, and Randolph D. Andrews

Subjects
medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, Clinical trial, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Physical therapy, medicine, Neurology (clinical), Geriatrics and Gerontology, Clinical care, business
Published
2015

42. Dissipative effects in spallation-induced fission ofPb208at high excitation energies

Author

D. Pérez-Loureiro, B. Jurado, A. Bacquias, S. Lukic, V. Henzl, M. V. Ricciardi, F. Farget, Y. Ayyad, C. Schmitt, J. L. Rodriguez-Sanchez, R. Pleskac, P. N. Nadtochy, T. Enqvist, J. Benlliure, Marcos Antônio Fernandez, E. Casarejos, K.-H. Schmidt, V. Henzlova, T. Kurtukian, A. Boudard, A. Kelic-Heil, and Son Nguyen Ngoc

Subjects
Physics, Nuclear and High Energy Physics, Proton, Fissile material, Fission, Nuclear Theory, Dissipation, 7. Clean energy, Nuclear physics, Nuclear fission, Physics::Atomic and Molecular Clusters, Dissipative system, Spallation, Atomic number, Nuclear Experiment
Abstract

Spallation reactions on fissile nuclei represent an appropriate tool to investigate dissipative effects in nuclear fission. In this work, we have studied transient and dissipative effects in proton- and deuteron-induced fission on Pb208 at 500A MeV. A dedicated experimental setup optimized for inverse kinematics measurements made it possible to identify in atomic number both fission fragments with high resolution, and reconstruct the charge of the fissioning system. We could then determine the width of the fission fragments charge distribution as well as partial fission cross sections, both as a function of the charge of the fissioning system. These two complementary observables permitted us to investigate the dynamics of the process at small deformation, i.e., from the ground state to the saddle point. The description of these observables with advanced model calculations reveals the influence of the nuclear dissipation in the fission process at high excitation energy and in particular its manifestation through transient time effects.

Published
2015

43. High accuracy U-235(n,f) data in the resonance energy region

Author

Carlos Guerrero, U. Abbondanno, I. Dillmann, I. Savvidis, M. Kerveno, C. Lederer, H. Leeb, A. Pavlik, L. Ferrant, F. Gramegna, D. Villamarin, Ralf Plag, I. Duran, A. Goverdovski, F. Gunsing, Christoph A. Stephan, F. Alvarez-Velarde, P. Pavlopoulos, C. Le Naour, M. Embid-Segura, S. David, A. Ventura, Cristian Massimi, P. Rullhusen, Gerald Badurek, Marco Calviani, F. Voss, P. M. Milazzo, G. Tagliente, A. Plukis, S. Lukic, A. Couture, G. Cortes, W.I. Furman, C. Rubbia, S. Isaev, C. Eleftheriadis, R. C. Haight, S. Marrone, K. Fujii, C. Paradela, P. Baumann, L. Perrot, K. Wisshak, J. Salgado, Thomas Rauscher, P. Cennini, A. Poch, Roberto Capote, L. Audouin, M. Krtička, F. Calviño, I. F. Gonçalves, D. Karadimos, R. Vlastou, E. Berthoumieux, V. Chepel, W. Dridi, C. Santos, M.C. Vincente, L. Tavora, M. Mosconi, L. Sarchiapone, E. González-Romero, E. Jericha, G. Aerts, R. Ferreira-Marques, T. Martinez, Rene Reifarth, S. Walter, J. L. Tain, P. E. Koehler, F. Becvar, A. Lindote, Diego Tarrio, J. M. Quesada, L. Tassan-Got, J. Marganiec, Nicola Colonna, S. Andriamonje, C. Carrapiço, R. Terlizzi, C. Weiss, V. Ketlerov, Vasilis Vlachoudis, H. Alvarez-Pol, E. Chiaveri, Javier Praena, P. F. Mastinu, Y. Kadi, C. Pretel, G. Rudolf, B. Berthier, Michael Heil, A. J. M. Plompen, Corrie S. Moreau, C. Lampoudis, C. Domingo-Pardo, M. Dahlfors, M. Wiesher, P. Vaz, D. Cano-Ott, Arnaud Ferrari, Alberto Mengoni, J. Andrzejewski, V. Konovalov, J. Cox, Masayuki Igashira, F. Kaeppeler, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, Serot, O., Paradela, C., Duran, I., Tassan-Got, L., Audouin, L., Berthier, B., Isaev, S., Le Naour, C., Stephan, C., Tarrío, D., Abbondanno, U., Aerts, G., Álvarez-Pol, H., Álvarez-Velarde, F., Andriamonje, S., Andrzejewski, J., Badurek, G., Baumann, P., Becvar, F., Berthoumieux, E., Calviño, F., Calviani, M., Cano-Ott, D., Capote, R., Carrapiço, C., Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Couture, A., Cox, J., Dahlfors, M., David, S., Dillmann, I., Domingo-Pardo, C., Dridi, W., Eleftheriadis, C., Embid-Segura, M., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Fujii, K., Furman, W., Gonçalves, I.F., Gonzalez-Romero, E., Goverdovski, A., Gramegna, F., Guerrero, C., Gunsing, F., Haight, R., Heil, M., Igashira, M., Jericha, E., Kadi, Y., Kaeppeler, F., Karadimos, D., Kerveno, M., Ketlerov, V., Koehler, P., Konovalov, V., Krticka, M., Lampoudis, C., Lederer, C., Leeb, H., Lindote, A., Lukic, S., Marganiec, J., Martinez, T., Marrone, S., Massimi, C., Mastinu, P., Mengoni, A., Milazzo, P.M., Moreau, C., Mosconi, M., Pancin, S, Pavlik, A., Pavlopoulos, P., Perrot, L., Plag, R., Plompen, A., Plukis, A., Poch, A., Pretel, C., Praena, J., Quesada, J., Rauscher, T., Reifarth, R., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Santos, C., Sarchiapone, L., Savvidis, I., Tagliente, G., Tain, J.L., Tavora, L., Terlizzi, R., Vaz, P., Ventura, A., Villamarin, D., Vincente, M.C., Vlachoudis, V., Vlastou, R., Voss, F., Walter, S., Weiss, C., Wiesher, M., and Wisshak, K.

Subjects
Nuclear reaction, Fission, nTOF, QC1-999, Neutron, 01 natural sciences, Resonance (particle physics), Nuclear physics, Subatomär fysik, Cross section (physics), U235, Ionization, 0103 physical sciences, Subatomic Physics, CERN, ddc:530, 010306 general physics, Physics, Energies::Energia nuclear [Àrees temàtiques de la UPC], Neutrons, Range (particle radiation), Large Hadron Collider, Física [Àrees temàtiques de la UPC], Reaccions nuclears, Cross section, 010308 nuclear & particles physics, Nuclear fission, nuclear technologies, Engineering physics, Física nuclear, Nuclear reactions
Abstract

The $^{235}$U neutron-induced cross section is widely used as reference cross section for measuring other fission cross sections, but in the resonance region it is not considered as an IAEA standard because of the scarce experimental data covering the full region. In this work, we deal with a new analysis of the experimental data obtained with a detection setup based on parallel plate ionization chambers (PPACs) at the CERN n_TOF facility in the range from 1 eV to 10 keV. The relative cross section has been normalised to the IAEA value in the region between 7.8 and 11 eV, which is claimed as well-known. Comparison with the ENDF/B-VII evaluation and the IAEA reference file from 100 eV to 10 keV are provided.

Published
2015

44. Dynamic range of the Barber filters

Author

Gordana S. Lukic

Subjects
Engineering, Dynamic range, business.industry, Low-pass filter, Transfer function, Band-pass filter, Control and Systems Engineering, Control theory, Parallel communication, Signal Processing, Multiplier (economics), Prototype filter, Computer Vision and Pattern Recognition, Electrical and Electronic Engineering, business, Frequency modulation, Software
Abstract

In this paper, the filters which consist of two parallel transmission paths (channels) will be presented. Each of them contains two multipliers and a lowpass filter, composed of standard components.The influence of non-identical channels will be considered towards the output signal. The "parasitical" signal appears as the consequence of non-identical channels. It limits the dynamic range of the Barber filters. The amplitudes of the "parasitical" signal components with a double modulation frequency are equal for both filters, the Barber bandpass filter and the Barber lowpass filter as it will be shown in the paper. The obtained relations ensure the determination of the dynamic range magnitude at definite frequency, order and approximation. The dynamic range value is inversely proportional to the magnitude of the channels non-identity. Analytical and graphical dependencies are provided for the correction of the permitted channels non-identity with the dynamic range necessary value of the filter. It is very important for the construction of the Barber filters to provide extremely low sensitivity by their application of the disposable elementary base. The Barber filters are very suitable for dynamic examinations and for creating polychannel filters.

Published
2006

45. Resonance neutron-capture cross sections of stable magnesium isotopes and their astrophysical implications

Author

MASSIMI, CRISTIAN, VANNINI, GIANNI, P. Koehler, S. Bisterzo, N. Colonna, R. Gallino, F. Gunsing, F. Käppeler, G. Lorusso, A. Mengoni, M. Pignatari, U. Abbondanno, G. Aerts, H. Álvarez, F. Álvarez Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulos, L. Audouin, G. Badurek, M. Barbagallo, P. Baumann, F. Bečvář, F. Belloni, M. Bennett, E. Berthoumieux, M. Calviani, F. Calviño, D. Cano Ott, R. Capote, C. Carrapiço, A. Carrillo de Albornoz, P. Cennini, V. Chepel, E. Chiaveri, G. Cortes, A. Couture, J. Cox, M. Dahlfors, S. David, I. Dillmann, R. Dolfini, C. Domingo Pardo, W. Dridi, I. Duran, C. Eleftheriadis, M. Embid Segura, L. Ferrant, A. Ferrari, R. Ferreira Marques, L. Fitzpatrick, H. Frais Koelbl, K. Fujii, W. Furman, I. Goncalves, E. González Romero, A. Goverdovski, F. Gramegna, E. Griesmayer, C. Guerrero, B. Haas, R. Haight, M. Heil, A. Herrera Martinez, F. Herwig, R. Hirschi, M. Igashira, S. Isaev, E. Jericha, Y. Kadi, D. Karadimos, D. Karamanis, M. Kerveno, V. Ketlerov, V. Konovalov, S. Kopecky, E. Kossionides, M. Krtička, C. Lampoudis, H. Leeb, C. Lederer, A. Lindote, I. Lopes, R. Losito, M. Lozano, S. Lukic, J. Marganiec, L. Marques, S. Marrone, T. Martínez, P. Mastinu, E. Mendoza, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neves, H. Oberhummer, S. O’Brien, M. Oshima, J. Pancin, C. Papachristodoulou, C. Papadopoulos, C. Paradela, N. Patronis, A. Pavlik, P. Pavlopoulos, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Plukis, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, G. Rockefeller, M. Rosetti, C. Rubbia, G. Rudolf, J. Salgado, C. Santos, L. Sarchiapone, R. Sarmento, I. Savvidis, C. Stephan, G. Tagliente, J. L. Tain, D. Tarrío, L. Tassan Got, L. Tavora, R. Terlizzi, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, V. Vlachoudis, R. Vlastou, F. Voss, S. Walter, H. Wendler, M. Wiescher, K. Wisshak, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Aval du cycle et Energie Nucléaire (ACEN), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Theorical Division (LANL), Los Alamos National Laboratory (LANL), Pôle Universitaire Léonard de Vinci, Pôle Universitaire Léonard de Vinci (PULV), C. Massimi, P. Koehler, S. Bisterzo, N. Colonna, R. Gallino, F. Gunsing, F. Käppeler, G. Lorusso, A. Mengoni, M. Pignatari, G. Vannini, U. Abbondanno, G. Aert, H. Álvarez, F. Álvarez-Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulo, L. Audouin, G. Badurek, M. Barbagallo, P. Baumann, F. Bečvář, F. Belloni, M. Bennett, E. Berthoumieux, M. Calviani, F. Calviño, D. Cano-Ott, R. Capote, C. Carrapiço, A. Carrillo de Albornoz, P. Cennini, V. Chepel, E. Chiaveri, G. Corte, A. Couture, J. Cox, M. Dahlfor, S. David, I. Dillmann, R. Dolfini, C. Domingo-Pardo, W. Dridi, I. Duran, C. Eleftheriadi, M. Embid-Segura, L. Ferrant, A. Ferrari, R. Ferreira-Marque, L. Fitzpatrick, H. Frais-Koelbl, K. Fujii, W. Furman, I. Goncalve, E. González-Romero, A. Goverdovski, F. Gramegna, E. Griesmayer, C. Guerrero, B. Haa, R. Haight, M. Heil, A. Herrera-Martinez, F. Herwig, R. Hirschi, M. Igashira, S. Isaev, E. Jericha, Y. Kadi, D. Karadimo, D. Karamani, M. Kerveno, V. Ketlerov, V. Konovalov, S. Kopecky, E. Kossionide, M. Krtička, C. Lampoudi, H. Leeb, C. Lederer, A. Lindote, I. Lope, R. Losito, M. Lozano, S. Lukic, J. Marganiec, L. Marque, S. Marrone, T. Martínez, P. Mastinu, E. Mendoza, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neve, H. Oberhummer, S. O’Brien, M. Oshima, J. Pancin, C. Papachristodoulou, C. Papadopoulo, C. Paradela, N. Patroni, A. Pavlik, P. Pavlopoulo, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Pluki, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, G. Rockefeller, M. Rosetti, C. Rubbia, G. Rudolf, J. Salgado, C. Santo, L. Sarchiapone, R. Sarmento, I. Savvidi, C. Stephan, G. Tagliente, J. L. Tain, D. Tarrío, L. Tassan-Got, L. Tavora, R. Terlizzi, P. Vaz, A. Ventura, D. Villamarin, V. Vlachoudi, R. Vlastou, F. Vo, S. Walter, H. Wendler, M. Wiescher, K. Wisshak, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, Universitat Politècnica de Catalunya. GREENER - Grup de recerca d'estudis energètics i de les radiacions, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and TOF

Subjects
Nuclear and High Energy Physics, STELLAR CROSS SECTION, Astrophysics and Astronomy, Neutrons--Captura, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Neutrons--Capture, Nuclear physics, 0103 physical sciences, Neutron, Nuclear Physics - Experiment, 010306 general physics, Nuclear Experiment, Isotopes of magnesium, Physics, NUCLEAR ASTROPHYSICS, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider, Isotope, 010308 nuclear & particles physics, Nuclear energy, NEUTRON INDUCED NUCLEAR REACTION, Neutron spectroscopy, Neutron capture, 13. Climate action, S PROCESS, Energia nuclear, RESONANCE SPECTROSCOPY, Atomic physics, s-process, Shape analysis (digital geometry)
Abstract

We have measured the neutron capture cross sections of the stable magnesium isotopes 24,25,26Mg in the energy range of interest to the s process using the neutron time-of-flight facility n_TOF at CERN. Capture events from a natural metal sample and from samples enriched in 25Mg and 26Mg were recorded using the total energy method based on C6 2H6 detectors. Neutron resonance parameters were extracted by a simultaneous resonance shape analysis of the present capture data and existing transmission data on a natural isotopic sample. Maxwellian-averaged capture cross sections for the three isotopes were calculated up to thermal energies of 100 keV and their impact on s-process analyses was investigated. At 30 keV the new values of the stellar cross section for 24Mg, 25Mg, and 26Mg are 3.8±0.2 mb, 4.1±0.6 mb, and 0.14±0.01 mb, respectively.

Published
2012

46. Neutron-induced fission cross section measurement of233U,241Am and243Am in the energy range 0.5 MeV ⩽En⩽ 20 MeV at n_TOF at CERN

Author

G. Cortes, J. Pancin, C. Lederer, R. Vlastou, H. Leeb, S. David, L. Perrot, P. Cennini, F. Calvino, Anton Wallner, Corrie S. Moreau, V. Chepel, Roberto Capote, P. Baumann, Y. Kadi, G. Tagliente, P.A. Assimakopoulos, M. Kerveno, C. Eleftheriadis, A. Goverdovski, F. Alvarez-Velarde, H. Frais-Koelbl, Thomas Rauscher, M. Dahlfors, F. Gunsing, Gerald Badurek, R. Dolfini, G. Aerts, M. Mosconi, P. Vaz, G. Vannini, J. Marganiec, S. Andriamonje, Marco Calviani, Cristian Massimi, P. Pavlopoulos, Aaron Couture, J. Salgado, A. J. M. Plompen, F. Belloni, C. Stephan, S. O'Brien, Mario Barbagallo, Carlos Guerrero, A. Poch, Marco T. Pigni, D. Karadimos, I. Dillmann, G. Rudolf, F. Cerutti, D. Cano-Ott, C. Pretel, E. Chiaveri, E. Jericha, L. Marques, I. Lopes, Michael Heil, A. Pavlik, Heinz Oberhummer, C. Santos, P. F. Mastinu, R. Terlizzi, S. Walter, C. Domingo-Pardo, L. Ferrant, K. Wisshak, A. Lindote, James L. Cox, E. González-Romero, L. Fitzpatrick, L. Tavora, K. Fujii, R. C. Haight, Masayuki Igashira, C. Paradela, H. Wendler, L. Audouin, M. Embid-Segura, D. Villamarin, P. E. Koehler, P. Rullhusen, V. Ketlerov, Michael Wiescher, L. Sarchiapone, ntof, F. Bečvář, M. Meaze, Manuel Lozano, Ralf Plag, H. Álvarez, M. Oshima, M. Krtička, J. L. Tain, C Lampoudis, J. Andrzejewski, M. Rosetti, F. Voss, W.I. Furman, C. T. Papadopoulos, E. Kossionides, R. Ferreira-Marques, T. Martinez, I. Duran, C. A. Papachristodoulou, F. Neves, P. M. Milazzo, C. Rubbia, V. Konovalov, Javier Praena, Isabel S. Gonçalves, A. Plukis, S. Marrone, A. Carrillo de Albornoz, F. Käppeler, E. Griesmayer, S. Lukic, Nicola Colonna, A. Herrera-Martinez, N. Patronis, Arnaud Ferrari, Vasilis Vlachoudis, Alberto Mengoni, A. Ventura, F. Gramegna, I. Savvidis, B. Haas, M. C. Vincente, W. Dridi, Rene Reifarth, J. M. Quesada, L. Tassan-Got, S. Isaev, U. Abbondanno, E. Berthoumieux, C. Carrapiço, D. Karamanis, F Belloni, P M Milazzo, M Calviani, N Colonna, P Mastinu, U Abbondanno, G Aert, H Álvarez, F Álvarez-Velarde, S Andriamonje, J Andrzejewski, P Assimakopoulo, L Audouin, G Badurek, M Barbagallo, P Baumann, F Bečvář, E Berthoumieux, F Calviño, F Cerutti, D Cano-Ott, R Capote, C Carrapiço, A Carrillo de Albornoz, P Cennini, V Chepel, E Chiaveri, G Corte, A Couture, J Cox, M Dahlfor, S David, I Dillmann, R Dolfini, C Domingo-Pardo, W Dridi, I Duran, C Eleftheriadi, M Embid-Segura, L Ferrant, A Ferrari, R Ferreira-Marque, L Fitzpatrick, H Frais-Koelbl, K Fujii, W Furman, I Goncalve, E González-Romero, A Goverdovski, F Gramegna, E Griesmayer, C Guerrero, F Gunsing, B Haa, R Haight, M Heil, A Herrera-Martinez, M Igashira, S Isaev, E Jericha, F Käppeler, Y Kadi, D Karadimo, D Karamani, V Ketlerov, M Kerveno, P Koehler, V Konovalov, E Kossionide, M Krtička, C Lampoudi, C Lederer, H Leeb, A Lindote, I Lope, M Lozano, S Lukic, J Marganiec, L Marque, S Marrone, T Martínez, C Massimi, M H Meaze, A Mengoni, C Moreau, M Mosconi, F Neve, H Oberhummer, S O'Brien, M Oshima, J Pancin, C Papachristodoulou, C Papadopoulo, C Paradela, N Patroni, A Pavlik, P Pavlopoulo, L Perrot, M T Pigni, R Plag, A Plompen, A Pluki, A Poch, J Praena, C Pretel, J Quesada, T Rauscher, R Reifarth, M Rosetti, C Rubbia, G Rudolf, P Rullhusen, J Salgado, C Santo, L Sarchiapone, I Savvidi, C Stephan, G Tagliente, J L Tain, L Tassan-Got, L Tavora, R Terlizzi, G Vannini, P Vaz, A Ventura, D Villamarin, M C Vincente, V Vlachoudi, R Vlastou, F Vo, A Wallner, S Walter, H Wendler, M Wiescher, and K Wisshak

Subjects
Fission, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, 01 natural sciences, 7. Clean energy, Nuclear physics, Cross section (physics), 0103 physical sciences, Neutron cross section, Neutron, 010306 general physics, Nuclear Experiment, Mathematical Physics, EMERGING NUCLEAR TECHNOLOGIES, Physics, Large Hadron Collider, 010308 nuclear & particles physics, Neutron radiation, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, NEUTRON INDUCED FISSION, Time of flight, TIME-OF-FLIGHT, Ionization chamber, Physics::Accelerator Physics, Atomic physics
Abstract

Neutron-induced fission cross section measurements of U-233, Am-243 and Am-241 relative to U-235 have been carried out at the neutron time-of-flight facility n_TOF at CERN. A fast ionization chamber has been employed. All samples were located in the same detector; therefore the studied elements and the reference U-235 target are subject to the same neutron beam.

Published
2012

47. New experimental validation of the pulse height weighting technique for capture cross-section measurements

Author

L. Perrot, J. Pancin, F. Voss, Marco Radici, K. Wisshak, Ch.O. Bacri, V. Chepel, E. Berthomieux, L. Zanini, S. Marrone, P. Baumann, A. Lindote, T. Papaevangelou, M. Vincente-Vincente, Nicola Colonna, C. Tapia, M. Dahlfors, P. Vaz, G. Vannini, Per Carlson, M. Embid-Segura, H. Frais-Koelbl, E. Savvidis, F. Rejmund, H. Wendler, J. Salgado, A. Poch, Y. Giomataris, H. Álvarez, J. L. Tain, Saed Dababneh, L. Tavora, K.G. Ioannides, F. Gramegna, I. Duran, Aaron Couture, D. Cortina, M. Terrani, A. Goverdovski, George Kitis, F. Neves, P. M. Milazzo, A. Herrera-Martinez, Manuel Lozano, B. Berthier, R. Vlastou, F. Gunsing, Gerald Badurek, Ralf Plag, J. Benlliure, Alberto Mengoni, G. Cortes, A. Molina-Coballes, G. Aerts, A. Pavlik, N. Tsangas, Enrico Chiaveri, M. Rosetti, W. Rapp, P. Rullhusen, E. Gonzalez-Romero, R. Dolfini, N. Janeva, C. Domingo-Pardo, C. Eleftheriadis, E. Boscolo-Marchi, C. Paradela, E. Jericha, S. Markov, Roberto Capote, S. Lukic, A. Perez-Parra, Rene Reifarth, P. E. Koehler, P.A. Assimakopoulos, A. Kelic, I. F. Gonçalves, D. Cano-Ott, A. Plukis, P. Pavlopoulos, M.I. Lopes, F. Bečvář, P. Cennini, José M. Martínez-Val, S. David, J. M. Quesada, L. Tassan-Got, Sigfrido Boffi, S. Andriamonje, G. Tagliente, U. Abbondanno, Yacine Kadi, J.C. Soares, José Manuel Perlado, L. Ferrant, D. Karamanis, C. Borcea, C. Coceva, L. Ferreira-Lourenco, R. C. Haight, Heinz Oberhummer, Alfredo Ferrari, R. Ferreira-Marques, C. Stephan, S. O'Brien, E. Griesmayer, P. F. Mastinu, Michael Heil, A. Ventura, H. Beer, R. Terlizzi, E. Kossionides, H. Leeb, V. Ketlerov, D. Villamarin-Fernandez, F. Käppeler, Michael Wiescher, W.I. Furman, Carlo Rubbia, E. Mínguez, Subramanian Raman, A. J. M. Plompen, V. Peskov, V. Vlachoudis, A. Angelopoulos, N. Bustreo, G. Rudolf, P. Calviño, C. Moreau, V. Konovalov, V. Lacoste, C. Pretel, James L. Cox, Thomas Rauscher, A.J.P.L. Policarpo, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), TOF, U.Abbondanno, G.Aert, H.Alvarez, S.Adriamonje, A.Angelopoulo, P.Assimakopoulo, C.Bacri, C.Badurek, P.Bauman, F.Becvar, H.Beer, J.Benlliure, B.Berthier, E.Berthoumieux, S.Boffi, C.Borcea, N.Bustreo, F.Calvino, D.Cano-Ott, R.Capote, P.Carlson, P.Cennini, V.Chepel, E.Chiaveri, N.Colonna, G.Corte, D.Cortina, A.Couture, J.Cox, S.Dababneh, M.Dahlfor, S.David, R.Dolfini, C.Domingo, I.Dura-Escribano, C.Eleftheriadi, M.Embid-Segura, L.Ferrant, A.Ferrari, L.Ferreira-Lourenco, R.Ferreira-Marque, H.Frais-Koelbl, W.Furman, Y.Giomatari, I.Goncalve, E.Gonzales-Romero, A.Goverdovski, F.Gramegna, E.Griiesmayer, F.GGunsing, R.Haight, M.Heil, A.Errera-Martinez, K.Ioannide, N.Janeva, E.Jericha, Y.Kadi, F.Kappeler, D.Karamani, A.Kelic, V.Ketlerov, G.Kiti, P.Koehler, V.Konovalov, E.Kossionide, V.Lacoste, H.Leeb, A.Lindote, I.Lope, M.Lozano, S.Lukic, S.Markov, S.Marrone, J.Martinez-Val, P.Mastinu, A.Mengoni, P.Milazzo, E.Minguez, C.Moreau, F.Neve, H.Oberhummer, S.O’Brien, J.Pancin, C.Paradela, A.Pavlik, P.Pavlopoulo, A.Perez-Parra, J.Perlado, L.Perrot, V.Peskov, R.Plag, A.Plomplen, A.Pluki, A.Poch, A.policarpo, C.Pretel, J.Quesada, M.Radici, W.Rapp, R.Reifarth, F.Rejmund, M.Rosetti, C.Rubbia, G.Rudolf, P.Rullhusen, J.Salgado, E.Savvidi, C.Stephan, G.Tagliente, J.Tain, C.Tapia, L.Tassan-Got, L.Tavora, M.Terrani, N.Tsanga, G.Vannini, P.Vaz, A.Ventura, D.Villamarin-Fernandez, M.Vincente-Vincente, V.Vlachoudi, R.Vlastou, F.Vo, H.Wendler, M.Wiescher, K.Wisshak, and L.Zanini

Subjects
Nuclear and High Energy Physics, TheoryofComputation_COMPUTATIONBYABSTRACTDEVICES, Monte Carlo method, NUCLEAR PHYSICS, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], ComputingMethodologies_ARTIFICIALINTELLIGENCE, 01 natural sciences, monte carlo simulations, Cross section (physics), Optics, 0103 physical sciences, neutron capture cross-sections, 010306 general physics, Instrumentation, Pulse height, Physics, 010308 nuclear & particles physics, business.industry, Liquid scintillation counting, Detector, TheoryofComputation_GENERAL, Experimental validation, NEUTRON CROSS SECTIONS, pulse height weighting technique, c6d6 scintillation detectors, Weighting, Neutron capture, ComputingMethodologies_PATTERNRECOGNITION, business
Abstract

The accuracy of the pulse height weighting technique for the determination of neutron capture cross-sections is investigated. The technique is applied to measurements performed with C6D6 liquid scintillation detectors of two different types using capture samples of various dimensions. The data for well-known (n, gamma) resonances are analyzed using weighting functions obtained from Monte Carlo simulations of the experimental set-up. Several causes of systematic deviation are identified and their effect is quantified. In all the cases measured the reaction yield agrees with the standard value within 2%. (C) 2003 Elsevier B.V. All rights reserved. Nuclear Instruments & Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment

Published
2004

48. Neutron-induced fission cross section of nat-Pb and 209-Bi from threshold to 1 GeV: An improved parametrization

Author

D. Tarrío, L. Tassan Got, L. Audouin, B. Berthier, I. Duran, L. Ferrant, S. Isaev, C. Le Naour, C. Paradela, C. Stephan, D. Trubert, U. Abbondanno, G. Aerts, H. Álvarez, F. Álvarez Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulos, G. Badurek, P. Baumann, F. Bečvář, E. Berthoumieux, F. Calviño, M. Calviani, D. Cano Ott, R. Capote, C. Carrapiço, P. Cennini, V. Chepel, E. Chiaveri, N. Colonna, G. Cortes, A. Couture, J. Cox, M. Dahlfors, S. David, I. Dillmann, C. Domingo Pardo, W. Dridi, C. Eleftheriadis, M. Embid Segura, A. Ferrari, R. Ferreira Marques, K. Fujii, W. Furman, I. Goncalves, E. González Romero, F. Gramegna, C. Guerrero, F. Gunsing, B. Haas, R. Haight, M. Heil, A. Herrera Martinez, M. Igashira, E. Jericha, Y. Kadi, F. Käppeler, D. Karadimos, D. Karamanis, M. Kerveno, P. Koehler, E. Kossionides, M. Krtička, C. Lampoudis, H. Leeb, A. Lindote, I. Lopes, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, T. Martínez, P. Mastinu, A. Mengoni, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neves, H. Oberhummer, S. O’Brien, M. Oshima, J. Pancin, C. Papachristodoulou, C. Papadopoulos, N. Patronis, A. Pavlik, P. Pavlopoulos, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Plukis, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, C. Santos, L. Sarchiapone, I. Savvidis, G. Tagliente, J. L. Tain, L. Tavora, R. Terlizzi, P. Vaz, A. Ventura, D. Villamarin, M. C. Vincente, V. Vlachoudis, R. Vlastou, F. Voss, S. Walter, M. Wiescher, K. Wisshak, MASSIMI, CRISTIAN, VANNINI, GIANNI, D. Tarrío, L. Tassan-Got, L. Audouin, B. Berthier, I. Duran, L. Ferrant, S. Isaev, C. Le Naour, C. Paradela, C. Stephan, D. Trubert, U. Abbondanno, G. Aert, H. Álvarez, F. Álvarez-Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulo, G. Badurek, P. Baumann, F. Bečvář, E. Berthoumieux, F. Calviño, M. Calviani, D. Cano-Ott, R. Capote, C. Carrapiço, P. Cennini, V. Chepel, E. Chiaveri, N. Colonna, G. Corte, A. Couture, J. Cox, M. Dahlfor, S. David, I. Dillmann, C. Domingo-Pardo, W. Dridi, C. Eleftheriadi, M. Embid-Segura, A. Ferrari, R. Ferreira-Marque, K. Fujii, W. Furman, I. Goncalve, E. González-Romero, F. Gramegna, C. Guerrero, F. Gunsing, B. Haa, R. Haight, M. Heil, A. Herrera-Martinez, M. Igashira, E. Jericha, Y. Kadi, F. Käppeler, D. Karadimo, D. Karamani, M. Kerveno, P. Koehler, E. Kossionide, M. Krtička, C. Lampoudi, H. Leeb, A. Lindote, I. Lope, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, T. Martínez, C. Massimi, P. Mastinu, A. Mengoni, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neve, H. Oberhummer, S. O’Brien, M. Oshima, J. Pancin, C. Papachristodoulou, C. Papadopoulo, N. Patroni, A. Pavlik, P. Pavlopoulo, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Pluki, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, C. Santo, L. Sarchiapone, I. Savvidi, G. Tagliente, J. L. Tain, L. Tavora, R. Terlizzi, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, M. C. Vincente, V. Vlachoudi, R. Vlastou, F. Vo, S. Walter, M. Wiescher, and K. Wisshak.

Subjects
Physics::Instrumentation and Detectors, NEUTRON-INDUCED REACTION, Nuclear Theory, Nuclear Experiment, FISSION
Abstract

Neutron-induced fission cross sections for natPb and 209Bi were measured with a white-spectrum neutron source at the CERN Neutron Time-of-Flight (n_TOF) facility. The experiment, using neutrons from threshold up to 1 GeV, provides the first results for these nuclei above 200 MeV. The cross sections were measured relative to 235U and 238U in a dedicated fission chamber with parallel plate avalanche counter detectors. Results are compared with previous experimental data. Upgraded parametrizations of the cross sections are presented, from threshold energy up to 1 GeV. The proposed new sets of fitting parameters improve former results along the whole energy range.

Published
2011

49. 197-Au(n,gamma) cross section in the uresolved resonance region

Author

C. Lederer, N. Colonna, C. Domingo Pardo, F. Gunsing, F. Käppeler, A. Mengoni, A. Wallner, U. Abbondanno, G. Aerts, H. Álvarez, F. Álvarez Velarde, S. Andriamonje, J. Andrzejewski, L. Audouin, P. Assimakopoulos, G. Badurek, P. Baumann, F. Bečvář, F. Belloni, E. Berthoumieux, F. Calviño, M. Calviani, D. Cano Ott, R. Capote, C. Carrapiço, P. Cennini, V. Chepel, E. Chiaveri, G. Cortes, A. Couture, J. Cox, M. Dahlfors, S. David, I. Dillmann, W. Dridi, I. Duran, C. Eleftheriadis, L. Ferrant, A. Ferrari, R. Ferreira Marques, K. Fujii, W. Furman, S. Galanopoulos, I. F. Gonçalves, E. González Romero, F. Gramegna, C. Guerrero, B. Haas, R. Haight, M. Heil, A. Herrera Martinez, M. Igashira, E. Jericha, Y. Kadi, D. Karadimos, D. Karamanis, M. Kerveno, P. Koehler, E. Kossionides, M. Krtička, C. Lampoudis, H. Leeb, A. Lindote, I. Lopes, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, T. Martínez, P. Mastinu, E. Mendoza, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neves, H. Oberhummer, S. O’Brien, J. Pancin, C. Papadopoulos, C. Paradela, A. Pavlik, P. Pavlopoulos, G. Perdikakis, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Plukis, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, M. Rosetti, C. Rubbia, G. Rudolf, P. Rullhusen, L. Sarchiapone, R. Sarmento, I. Savvidis, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan Got, L. Tavora, R. Terlizzi, P. Vaz, A. Ventura, D. Villamarin, V. Vlachoudis, R. Vlastou, F. Voss, S. Walter, M. Wiescher, K. Wisshak, MASSIMI, CRISTIAN, VANNINI, GIANNI, C. Lederer, N. Colonna, C. Domingo-Pardo, F. Gunsing, F. Käppeler, C.Massimi, A. Mengoni, A. Wallner, U. Abbondanno, G. Aert, H. Álvarez, F. Álvarez-Velarde, S. Andriamonje, J. Andrzejewski, L. Audouin, P. Assimakopoulo, G. Badurek, P. Baumann, F. Bečvář, F. Belloni, E. Berthoumieux, F. Calviño, M. Calviani, D. Cano-Ott, R. Capote, C. Carrapiço, P. Cennini, V. Chepel, E. Chiaveri, G. Corte, A. Couture, J. Cox, M. Dahlfor, S. David, I. Dillmann, W. Dridi, I. Duran, C. Eleftheriadi, L. Ferrant, †, A. Ferrari, R. Ferreira-Marque, K. Fujii, W. Furman, S. Galanopoulo, I. F. Gonçalve, E. González-Romero, F. Gramegna, C. Guerrero, B. Haa, R. Haight, M. Heil, A. Herrera-Martinez, M. Igashira, E. Jericha, Y. Kadi, D. Karadimo, D. Karamani, M. Kerveno, P. Koehler, E. Kossionide, M. Krtička, C. Lampoudi, H. Leeb, A. Lindote, I. Lope, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, T. Martínez, P. Mastinu, E. Mendoza, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neve, H. Oberhummer, S. O’Brien, J. Pancin, C. Papadopoulo, C. Paradela, A. Pavlik, P. Pavlopoulo, G. Perdikaki, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Pluki, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, M. Rosetti, C. Rubbia, G. Rudolf, P. Rullhusen, L. Sarchiapone, R. Sarmento, I. Savvidi, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan-Got, L. Tavora, R. Terlizzi, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, V. Vlachoudi, R. Vlastou, F. Vo, S. Walter, M. Wiescher, and K. Wisshak.

Subjects
NEUTRON-INDUCED REACTION, NEUTRON CAPTURE
Abstract

The cross section of the reaction 197Au(n,γ) was measured with the time-of-flight technique at the n_TOF (neutron time-of-flight) facility in the unresolved resonance region between 5 and 400 keV using a pair of C6D6 (where D denotes 2H) liquid scintillators for the detection of prompt capture γ rays. The results with a total uncertainty of 3.9%–6.7% for a resolution of 20 bins per energy decade show fair agreement with the Evaluated Nuclear Data File Version B-VII.0 (ENDF/B-VII.0), which contains the standard evaluation. The Maxwellian-averaged cross section (MACS) at 30 keV is in excellent agreement with the one according to the ENDF/B-VII.0 evaluation and 4.7% higher than the MACS measured independently by activation technique. Structures in the cross section, which had also been reported earlier, have been interpreted as being due to clusters of resonances.

Published
2011

50. Neutron-induced fission cross-sectionof 233-U in the energy range 0.5<20 MeV

Author

The n_TOF Collaboration, F. Belloni, M. Calviani, N. Colonna, P. Mastinu, P. M. Milazzo, U. Abbondanno, G. Aerts, H. Álvarez, F. Alvarez Velarde, S. Andriamonje, J. Andrzejewski, L. Audouin, G. Badurek, P. Baumann, F. Bečvář, E. Berthoumieux, F. Calviño, D. Cano Ott, R. Capote, C. Carrapiço, P. Cennini, V. Chepel, E. Chiaveri, G. Cortes, A. Couture, J. Cox, M. Dahlfors, S. David, I. Dillmann, C. Domingo Pardo, W. Dridi, I. Duran, C. Eleftheriadis, M. Embid Segura, A. Ferrari, R. Ferreira Marques, K. Fujii, W. Furman, I. Goncalves, E. Gonzalez Romero, A. Goverdovski, F. Gramegna, C. Guerrero, F. Gunsing, B. Haas, R. Haight, M. Heil, A. Herrera Martinez, M. Igashira, E. Jericha, F. Käppeler, Y. Kadi, D. Karadimos, D. Karamanis, M. Kerveno, P. Koehler, E. Kossionides, M. Krtička, C. Lamboudis, H. Leeb, A. Lindote, I. Lopes, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, T. Martınez, MASSIMI, CRISTIAN, M. H. Meaze, A. Mengoni, C. Moreau, M. Mosconi, F. Neves, H. Oberhummer, S. O’Brien, J. Pancin, C. Papachristodoulou, C. Papadopoulos, C. Paradela, N. Patronis, A. Pavlik, P. Pavlopoulos, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Plukis, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, M. Rosetti, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, C. Santos, L. Sarchiapone, I. Savvidis, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan Got, L. Tavora, R. Terlizzi, VANNINI, GIANNI, P. Vaz, A. Ventura, D. Villamarin, M. C. Vincente, V. Vlachoudis, R. Vlastou, F. Voss, S. Walter, M. Wiescher, K. Wisshak, The n_TOF Collaboration, F. Belloni, M. Calviani, N. Colonna, P. Mastinu, P. M. Milazzo, U. Abbondanno, G. Aert, H. Álvarez, F. Alvarez-Velarde, S. Andriamonje, J. Andrzejewski, L. Audouin, G. Badurek, P. Baumann, F. Bečvář, E. Berthoumieux, F. Calviño, D. Cano-Ott, R. Capote, C. Carrapiço, P. Cennini, V. Chepel, E. Chiaveri, G. Corte, A. Couture, J. Cox, M. Dahlfor, S. David, I. Dillmann, C. Domingo-Pardo, W. Dridi, I. Duran, C. Eleftheriadi, M. Embid-Segura, A. Ferrari, R. Ferreira-Marque, K. Fujii, W. Furman, I. Goncalve, E. Gonzalez-Romero, A. Goverdovski, F. Gramegna, C. Guerrero, F. Gunsing, B. Haa, R. Haight, M. Heil, A. Herrera-Martinez, M. Igashira, E. Jericha, F. Käppeler, Y. Kadi, D. Karadimo, D. Karamani, M. Kerveno, P. Koehler, E. Kossionide, M. Krtička, C. Lamboudi, H. Leeb, A. Lindote, I. Lope, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, T. Martınez, C. Massimi, M. H. Meaze, A. Mengoni, C. Moreau, M. Mosconi, F. Neve, H. Oberhummer, S. O’Brien, J. Pancin, C. Papachristodoulou, C. Papadopoulo, C. Paradela, N. Patroni, A. Pavlik, P. Pavlopoulo, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Pluki, A. Poch, J. Praena, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, M. Rosetti, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, C. Santo, L. Sarchiapone, I. Savvidi, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan-Got, L. Tavora, R. Terlizzi, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, M. C. Vincente, V. Vlachoudi, R. Vlastou, F. Vo, S. Walter, M. Wiescher, and K. Wisshak

Subjects
NEUTRON-INDUCED REACTION, Nuclear Experiment, FISSION
Abstract

The neutron-induced fission cross-section of 233U has been measured at the CERN n_TOF facility relative to the standard fission cross-section of 235U between 0.5 and 20MeV. The experiment was performed with a fast ionization chamber for the detection of the fission fragments and to discriminate against α -particles from the natural radioactivity of the samples. The high instantaneous flux and the low background of the n_TOF facility result in data with uncertainties of ≈ 3% , which were found in good agreement with previous experiments. The high quality of the present results allows to improve the evaluation of the 233U (n,f) cross-section and, consequently, the design of energy systems based on the Th/U cycle.

Published
2011

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