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243 results on '"S. Khatua"'

1. Activity performance and kinetics for glycerol carbonylation with urea over <scp>Zn‐Co</scp> mixed metal oxide catalyst

Author: Sharda E. Kondawar, Gaytri B. Kasar, Angshuman S. Khatua, and Chandrashekhar V. Rode
Subjects: General Chemical Engineering
Published: 2022
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2. Assessment of functional disability among patients attending a geriatric psychiatry clinic

Author: C. Sharma, S. Khatua, and P. Dey
Subjects: Gerontology, Psychosis, 030219 obstetrics & reproductive medicine, Activities of daily living, business.industry, Cross-sectional study, Specialty, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Functional disability, Informed consent, medicine, Dementia, 030212 general & internal medicine, Neurology (clinical), Geriatrics and Gerontology, business, Geriatric psychiatry
Abstract: Summary Background Aging is associated with physical impairment and functional disability, mainly assessed in terms of activities of daily living (ADL). Assessment using this tool is one of the best ways to evaluate the health status of the elderly. Earlier studies have considered different variables such as those linked to functional disabilities, but psychiatric morbidity has been very little explored in the existing literature. Aims and objectives To estimate the prevalence of functional disability in terms of restriction in the activities of daily living (ADL) and the factors associated with it among elderly subjects attending a geriatric psychiatry clinic. Materials and methods Hospital-based cross sectional study. One hundred and fifty patients over sixty years old attending a geriatric psychiatry clinic in a tertiary care specialty hospital in eastern India were enrolled in the study after their informed consent, using a purposive sampling method. After clinical diagnosis, the activities of daily living were assessed using Barthel's 10-item index, and patients were graded accordingly. The data was analyzed on SPSS version 25.0. Results On the basis of Barthel's 10-item Index score, 72% of the subjects exhibited dependency, among whom 4% were totally dependent. Patients aged over 66 years and those with dementia, psychosis or other psychiatric diseases exhibited significantly higher levels of impairment. Impairments were mostly in the self-care domain. Conclusion The high prevalence of functional disability among elderly subjects with psychiatric morbidity in this study suggests the need for a comprehensive geriatric assessment for these patients, in particular for autonomy, to improve their functional status and promote speedy recovery.
Published: 2021
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3. Evolving Role and Translation of Radiomics and Radiogenomics in Adult and Pediatric Neuro-Oncology

Author: Murat Ak, K.Z. Hein, Rivka R. Colen, S. Khatua, and S.A. Toll
Subjects: Diagnostic Imaging, medicine.medical_specialty, Modalities, business.industry, Adult Brain, Radiogenomics, Genomics, Radiomics, Neurology, Pediatric Neuro-Oncology, Artificial Intelligence, Neoplasms, Medical imaging, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Neurology (clinical), business, Child, Pseudoprogression
Abstract: Exponential technologic advancements in imaging, high-performance computing, and artificial intelligence, in addition to increasing access to vast amounts of diverse data, have revolutionized the role of imaging in medicine. Radiomics is defined as a high-throughput feature-extraction method that unlocks microscale quantitative data hidden within standard-of-care medical imaging. Radiogenomics is defined as the linkage between imaging and genomics information. Multiple radiomics and radiogenomics studies performed on conventional and advanced neuro-oncology image modalities show that they have the potential to differentiate pseudoprogression from true progression, classify tumor subgroups, and predict recurrence, survival, and mutation status with high accuracy. In this article, we outline the technical steps involved in radiomics and radiogenomics analyses with the use of artificial intelligence methods and review current applications in adult and pediatric neuro-oncology.
Published: 2022

4. Author response for 'Activity performance and kinetics for glycerol carbonylation with urea over <scp>Zn‐Co</scp> mixed metal oxide catalyst'

Author: null Sharda E. Kondawar, null Gaytri B. Kasar, null Angshuman S. Khatua, and null Chandrashekhar V. Rode
Published: 2022
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5. 380TiP A phase I/II dose-escalation and expansion cohort study of intracerebroventricular radioimmunotherapy using 177Lu-DTPA-omburtamab in pediatric and adolescent patients with recurrent or refractory medulloblastoma

Author: J.R. Nielsen, S. Khatua, C.L. Lind, and M. Düring
Subjects: Oncology, Medulloblastoma, medicine.medical_specialty, business.industry, medicine.medical_treatment, Hematology, medicine.disease, Phase i ii, Refractory, Internal medicine, Radioimmunotherapy, medicine, Dose escalation, business, Cohort study
Published: 2021
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6. Pharmacognostic Standardization and Free Radical Scavenging Evaluation of Meripilus giganteus (Pers.) P. Karst., A Potential Medicinal Mushroom

Author: K Acharya, S Khatua, and S Pal
Subjects: Meripilus giganteus, geography, Medicinal mushroom, geography.geographical_feature_category, biology, Traditional medicine, Pharmaceutical Science, biology.organism_classification, Karst, Scavenging
Abstract: Background: We aimed to assess the incidence of developing postoperative urethrocutaneous fistulae (UCF) while using either polyglactin 910 or polydioxanone for the repair of subcoronal hypospadias in paediatric patients. Methods: A multicenter, two-group posttest-only randomized experimental design was adopted for the study. The study was conducted at PNS Shifa Hospital Karachi, Combined Military Hospital Malir, Military Hospital Rawalpindi and Combined Military Hospital Multan from 2009 to 2016. Boys between the ages of 1 – 10 years with confirmed diagnosis of subcoronal hypospadias suitable for single stage repair with the Snodgrass technique and also completing a minimum follow up of 6 months were targeted for the study. The subjects were later randomized into PG group (those undergoing urethral repair with polyglactin 901) and PD group (those in whom polydioxanone was used). Both descriptive and inferential statistics were used for data analysis. SPSS v. 21.0 was used for data analysis with p > 0.05 taken as significant value. Results: Two hundred patients with confirmed diagnosis of subcoronal hypospadias were recruited for the study in the proposed study period. Twenty-nine patients (29%) in the PG and 26 (26%) in the PD group developed UCF. There were seven (7%) cases of wound infection in the PG group compared to four cases (4%) in the PD Group; all eleven of the said were among those who developed UCF. Meatal stenosis was observed in six patients (6%) in the PG group and in nine patients (9%) of the PD group. No significant difference in the incidence of postoperative urethral fistula formation with the use of polyglactin 910 versus polydioxanone was however reported by the study findings. Conclusion: As there was no significant difference in the incidence UCF between Polyglactin 910 and Polydioxanone, the choice of suture material should be based on economical variations and availability of the two products.
Published: 2017
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7. MEDULLOBLASTOMA

Author: G. Vaidyanathan, S. Gururangan, D. Bigner, M. Zalutsky, M. Morfouace, A. Shelat, J. Megan, B. B. Freeman, S. Robinson, S. Throm, J. M. Olson, X.-N. Li, K. R. Guy, G. Robinson, C. Stewart, A. Gajjar, M. Roussel, N. Sirachainan, S. Pakakasama, U. Anurathapan, A. Hansasuta, M. Dhanachai, C. Khongkhatithum, S. Hongeng, A. Feroze, K.-S. Lee, S. Gholamin, Z. Wu, B. Lu, S. Mitra, S. Cheshier, P. Northcott, C. Lee, T. Zichner, P. Lichter, J. Korbel, R. Wechsler-Reya, S. Pfister, I. P. T. Project, K. K.-W. Li, T. Xia, F. M. T. Ma, R. Zhang, L. Zhou, K.-M. Lau, H.-K. Ng, L. Lafay-Cousin, S. Chi, J. Madden, A. Smith, E. Wells, E. Owens, D. Strother, N. Foreman, R. Packer, E. Bouffet, T. Wataya, J. Peacock, M. D. Taylor, D. Ivanov, M. Garnett, T. Parker, C. Alexander, L. Meijer, R. Grundy, P. Gellert, M. Ashford, D. Walker, J. Brent, F. Z. Cader, D. Ford, A. Kay, R. Walsh, G. Solanki, A. Peet, M. English, T. Shalaby, G. Fiaschetti, S. Baulande, N. Gerber, M. Baumgartner, M. Grotzer, T. Hayase, Y. Kawahara, M. Yagi, T. Minami, N. Kanai, T. Yamaguchi, A. Gomi, A. Morimoto, R. Hill, S. Kuijper, J. Lindsey, E. Schwalbe, K. Barker, J. Boult, D. Williamson, Z. Ahmad, A. Hallsworth, S. Ryan, E. Poon, R. Ruddle, F. Raynaud, L. Howell, C. Kwok, A. Joshi, S. L. Nicholson, S. Crosier, S. Wharton, K. Robson, A. Michalski, D. Hargrave, T. Jacques, B. Pizer, S. Bailey, F. Swartling, K. Petrie, W. Weiss, L. Chesler, S. Clifford, L. Kitanovski, T. Prelog, B. F. Kotnik, M. Debeljak, M. A. Grotzer, A. Gevorgian, E. Morozova, I. Kazantsev, T. Iukhta, S. Safonova, E. Kumirova, Y. Punanov, B. Afanasyev, O. Zheludkova, W. Grajkowska, M. Pronicki, B. Cukrowska, B. Dembowska-Baginska, M. Lastowska, A. Murase, S. Nobusawa, Y. Gemma, F. Yamazaki, A. Masuzawa, T. Uno, T. Osumi, Y. Shioda, C. Kiyotani, T. Mori, K. Matsumoto, H. Ogiwara, N. Morota, J. Hirato, A. Nakazawa, K. Terashima, T. Fay-McClymont, K. Walsh, D. Mabbott, D. Sturm, P. A. Northcott, D. T. W. Jones, A. Korshunov, S. M. Pfister, M. Kool, C. Hooper, S. Hawes, U. Kees, N. Gottardo, P. Dallas, A. Siegfried, A. I. Bertozzi, A. Sevely, N. Loukh, C. Munzer, C. Miquel, F. Bourdeaut, T. Pietsch, C. Dufour, M. B. Delisle, D. Kawauchi, J. Rehg, D. Finkelstein, F. Zindy, T. Phoenix, R. Gilbertson, J. Trubicka, M. Borucka-Mankiewicz, E. Ciara, K. Chrzanowska, M. Perek-Polnik, D. Abramczuk-Piekutowska, D. Jurkiewicz, S. Luczak, P. Kowalski, M. Krajewska-Walasek, C. Sheila, S. Lee, C. Foster, B. Manoranjan, M. Pambit, R. Berns, A. Fotovati, C. Venugopal, K. O'Halloran, A. Narendran, C. Hawkins, V. Ramaswamy, M. Taylor, A. Singhal, J. Hukin, R. Rassekh, S. Yip, S. Singh, C. Duhman, S. Dunn, T. Chen, S. Rush, H. Fuji, Y. Ishida, T. Onoe, T. Kanda, Y. Kase, H. Yamashita, S. Murayama, Y. Nakasu, T. Kurimoto, A. Kondo, S. Sakaguchi, J. Fujimura, M. Saito, T. Arakawa, H. Arai, T. Shimizu, E. Jurkiewicz, P. Daszkiewicz, M. Drogosiewicz, V. Hovestadt, I. Buchhalter, N. N. Jager, A. Stuetz, P. Johann, C. Schmidt, M. Ryzhova, P. Landgraf, M. Hasselblatt, U. Schuller, M.-L. Yaspo, A. von Deimling, R. Eils, A. Modi, M. Patel, M. Berk, L.-x. Wang, G. Plautz, H. Camara-Costa, A. Resch, C. Lalande, V. Kieffer, G. Poggi, C. Kennedy, K. Bull, G. Calaminus, J. Grill, F. Doz, S. Rutkowski, M. Massimino, R.-D. Kortmann, B. Lannering, G. Dellatolas, M. Chevignard, D. Solecki, P. McKinnon, J. Olson, J. Hayden, D. Ellison, M. Buss, M. Remke, J. Lee, T. Caspary, R. Castellino, M. Sabel, G. Gustafsson, G. Fleischhack, M. Benesch, A. Navajas, R. Reddingius, M.-B. Delisle, D. Lafon, N. Sevenet, G. Pierron, O. Delattre, J. Ecker, I. Oehme, R. Mazitschek, M. Lodrini, H. E. Deubzer, A. E. Kulozik, O. Witt, T. Milde, D. Patmore, N. Boulos, K. Wright, S. Boop, T. Janicki, S. Burzynski, G. Burzynski, A. Marszalek, J. Triscott, M. Green, S. R. Rassekh, B. Toyota, C. Dunham, S. E. Dunn, K.-W. Liu, Y. Pei, L. Genovesi, P. Ji, M. Davis, C. G. Ng, Y.-J. Cho, N. Jenkins, N. Copeland, B. Wainwright, Y. Tang, S. Schubert, B. Nguyen, S. Masoud, A. Lee, M. Willardson, P. Bandopadhayay, G. Bergthold, S. Atwood, R. Whitson, J. Qi, R. Beroukhim, J. Tang, A. Oro, B. Link, J. Bradner, S. G. Vallero, D. Bertin, M. E. Basso, C. Milanaccio, P. Peretta, A. Cama, A. Mussano, S. Barra, G. Morana, I. Morra, P. Nozza, F. Fagioli, M. L. Garre, A. Darabi, E. Sanden, E. Visse, N. Stahl, P. Siesjo, D. Vaka, F. Vasquez, B. Weir, G. Cowley, C. Keller, W. Hahn, I. C. Gibbs, S. Partap, K. Yeom, M. Martinez, H. Vogel, S. S. Donaldson, P. Fisher, S. Perreault, L. Guerrini-Rousseau, S. Pujet, V. Kieffer-Renaux, M. A. Raquin, P. Varlet, A. Longaud, C. Sainte-Rose, D. Valteau-Couanet, J. Staal, L. S. Lau, H. Zhang, W. J. Ingram, Y. J. Cho, Y. Hathout, K. Brown, B. R. Rood, M. Handler, T. Hankinson, B. K. Kleinschmidt-Demasters, S. Hutter, D. T. Jones, N. Kagawa, R. Hirayama, N. Kijima, Y. Chiba, M. Kinoshita, K. Takano, D. Eino, S. Fukuya, F. Yamamoto, K. Nakanishi, N. Hashimoto, Y. Hashii, J. Hara, T. Yoshimine, J. Wang, C. Guo, Q. Yang, Z. Chen, I. Filipek, E. Swieszkowska, M. Tarasinska, D. Perek, R. Kebudi, B. Koc, O. Gorgun, F. Y. Agaoglu, J. Wolff, E. Darendeliler, K. Kerl, J. Gronych, J. McGlade, R. Endersby, H. Hii, T. Johns, J. Sastry, D. Murphy, M. Ronghe, C. Cunningham, F. Cowie, R. Jones, A. Calisto, M. Sangra, C. Mathieson, J. Brown, K. Phuakpet, V. Larouche, U. Bartels, T. Ishida, D. Hasegawa, K. Miyata, S. Ochi, A. Saito, A. Kozaki, T. Yanai, K. Kawasaki, K. Yamamoto, A. Kawamura, T. Nagashima, Y. Akasaka, T. Soejima, M. Yoshida, Y. Kosaka, A. von Bueren, T. Goschzik, R. Kortmann, K. von Hoff, C. Friedrich, A. z. Muehlen, M. Warmuth-Metz, N. Soerensen, F. Deinlein, I. Zwiener, A. Faldum, J. Kuehl, K. KRAMER, N. P. -Taskar, P. Zanzonico, J. L. Humm, S. L. Wolden, N.-K. V. Cheung, S. Venkataraman, I. Alimova, P. Harris, D. Birks, I. Balakrishnan, A. Griesinger, N. K. Foreman, R. Vibhakar, A. Margol, N. Robison, J. Gnanachandran, L. Hung, R. Kennedy, M. Vali, G. Dhall, J. Finlay, A. Erdrich-Epstein, M. Krieger, R. Drissi, M. Fouladi, F. Gilles, A. Judkins, R. Sposto, S. Asgharzadeh, A. Peyrl, M. Chocholous, S. Holm, P. Grillner, K. Blomgren, A. Azizi, T. Czech, B. Gustafsson, K. Dieckmann, U. Leiss, I. Slavc, S. Babelyan, I. Dolgopolov, R. Pimenov, G. Mentkevich, S. Gorelishev, M. Laskov, A. O. von Bueren, J. Nowak, R. D. Kortmann, M. Mynarek, K. Muller, N. U. Gerber, H. Ottensmeier, R. Kwiecien, M. Yankelevich, V. Boyarshinov, I. Glekov, S. Ozerov, S. Gorelyshev, A. Popa, N. Subbotina, A. M. Martin, C. Nirschl, M. Polanczyk, R. Bell, D. Martinez, L. M. Sullivan, M. Santi, P. C. Burger, J. M. Taube, C. G. Drake, D. M. Pardoll, M. Lim, L. Li, W.-G. Wang, J.-X. Pu, H.-D. Sun, R. Ruggieri, M. H. Symons, M. I. Vanan, S. Bolin, S. Schumacher, R. Zeid, F. Yu, N. Vue, W. Gibson, B. Paolella, F. J. Swartling, M. W. Kieran, J. E. Bradner, O. Maher, S. Khatua, N. Tarek, W. Zaky, T. Gupta, S. Mohanty, S. Kannan, R. Jalali, E. Kapitza, D. Denkhaus, A. z. Muhlen, D. G. van Vuurden, M. Garami, J. Fangusaro, T. B. Davidson, M. J. G. da Costa, J. Sterba, S. C. Clifford, J. L. Finlay, R. Schmidt, J. Felsberg, H. Skladny, F. Cremer, G. Reifenberger, R. Kunder, E. Sridhar, A. A. Moiyadi, A. Goel, N. Goel, N. Shirsat, R. Othman, L. Storer, I. Kerr, B. Coyle, N. Law, M. L. Smith, M. Greenberg, S. Laughlin, D. Malkin, F. Liu, I. Moxon-Emre, N. Scantlebury, A. Nasir, D. Onion, A. Lourdusamy, A. Grabowska, Y. Cai, T. Bradshaw, R. S. S. de Medeiros, A. Beaugrand, S. Soares, S. Epelman, W. Wang, M. Sultan, R. J. Wechsler-Reya, M. Zapatka, B. Radlwimmer, D. Alderete, L. Baroni, F. Lubinieki, F. Auad, M. L. Gonzalez, W. Puya, P. Pacheco, O. Aurtenetxe, A. Gaffar, L. Gros, O. Cruz, C. Calvo, N. Shinojima, H. Nakamura, J.-i. Kuratsu, A. Hanaford, C. Eberhart, T. Archer, P. Tamayo, S. Pomeroy, E. Raabe, K. De Braganca, S. Gilheeney, Y. Khakoo, K. Kramer, S. Wolden, I. Dunkel, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, D. Shih, X. Wang, C. Faria, C. Raybaud, U. Tabori, J. Rutka, S. Jacobs, F. De Vathaire, I. Diallo, D. Llanas, C. Verez, F. Diop, A. Kahlouche, S. Puget, E. Thompson, E. Prince, V. Amani, P. Sin-Chan, M. Lu, C. Kleinman, T. Spence, D. Picard, K. C. Ho, J. Chan, J. Majewski, N. Jabado, P. Dirks, A. Huang, J. R. Madden, A. M. Donson, D. M. Mirsky, A. Dubuc, S. Mack, D. Gendoo, B. Luu, T. MacDonald, T. Van Meter, S. Croul, A. Laureano, W. Brugmann, C. Denman, H. Singh, H. Huls, J. Moyes, D. Sandberg, L. Silla, L. Cooper, and D. Lee
Subjects: Oncology, Abstracts, Cancer Research, medicine.medical_specialty, Cns pnet, business.industry, Internal medicine, Meta-analysis, medicine, Neurology (clinical), business
Published: 2014
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8. RADIOLOGY

Author: T. Kelly, M. Prah, S. Jogal, M. Maheshwari, S. Lew, K. Schmainda, G. Kannan, S. Khatua, W. Zaky, L. Ketonen, M. Drogosiewicz, B. Dembowska-Baginska, E. Jurkiewicz, K. Nowak, D. Perek, D. Hirpara, M. Bhatt, K. Scheinemann, Y. Shimizu, A. Kondo, M. Miyajima, H. Arai, R. Dvir, S. Shiran, L. B.- Sira, J. Roth, U. Tabori, E. Bouffet, C. Durno, M. Aronson, S. Constantini, R. Elhasid, J. Fangusaro, J. Marsh, C. Bregman, A. Diaz, R. Byrne, E. Ziel, S. Goldman, R. Calmon, D. Grevent, T. Blauwblomme, S. Puget, C. Sainte-Rose, P. Varlet, C. Dufour, J. Grill, A. Saitovich, M. Zilbovicius, F. Brunelle, N. Boddaert, L. Wei, A. M. Tan, P. H. Tang, E. Orphanidou-Vlachou, N. Vlachos, N. Davies, T. Arvanitis, R. Grundy, A. Peet, S. Withey, J. Novak, L. MacPherson, S. Avula, R. Kumar, B. Pizer, B. Pettorini, D. Garlick, C. Mallucci, W. Reddick, J. Guo, J. Glass, J. Pryweller, A. Gajjar, S. Thust, E. Blanco, K. Mankad, and A. Michalski
Subjects: Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published: 2014
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9. CLIN-RADIATION THERAPY

Author: W.-S. Yoon, J.-T. Kim, Y.-M. Han, D.-S. Chung, Y.-S. Park, K. J. Lizarraga, M. Allen-Auerbach, A. A. De Salles, W. H. Yong, W. Chen, M. I. Ruge, P. Kickingereder, T. Simon, H. Treuer, V. Sturm, P. R. D'Alessandro, J. Jarrett, S. A. Walling, I. G. Fleetwood, T. G. Kim, D. H. Lim, S. L. McGovern, D. Grosshans, M. F. McAleer, M. Chintagumpala, S. Khatua, T. Vats, A. Mahajan, P. D. Beauchesne, G. Faure, G. Noel, T. Schmitt, L. Martin, E. Jadaud, C. Carnin, A. Astradsson, P. M. a. Rosenschold, A. K. W. Lund, U. Feldt-Rasmussen, H. Roed, M. Juhler, N. Kumar, R. Kumar, S. C. Sharma, K. K. Mukherjee, N. Khandelwal, P. K. Gupta, A. Bansal, R. Kapoor, S. Ghosal, C. L. Barney, A. P. Brown, M. C. Lowe, D. R. Grosshans, J. F. de Groot, V. Puduvalli, M. R. Gilbert, T. S. Vats, P. D. Brown, B. E. Pollock, S. L. Stafford, M. J. Link, Y. I. Garces, R. L. Foote, S. Ryu, E. Y. Kim, R. Yechieli, J. K. Kim, T. Mikkelsen, S. Kalkanis, J. Rock, G. K. Prithviraj, P. Oppelt, L. Arfons, K. C. Cuneo, J. Vredenburgh, A. Desjardins, K. Peters, J. Sampson, Z. Chang, J. Kirkpatrick, S. K. Nath, A. D. Sheridan, P. J. Rauch, J. N. Contessa, J. B. Yu, J. P. Knisely, F. J. Minja, A. O. Vortmeyer, V. L. Chiang, M. Koto, A. Hasegawa, R. Takagi, G. Sasahara, H. Ikawa, T. Kamada, Y. Iwadate, M. Matsutani, A. A. Kanner, G. Sela, E. Gez, D. Matceyevsky, N. Strauss, B. W. Corn, D. G. Brachman, K. A. Smith, P. Nakaji, S. Sorensen, K. J. Redmond, E. M. Mahone, L. Kleinberg, S. Terezakis, T. McNutt, H. Agbahiwe, K. Cohen, M. Lim, M. Wharam, A. Horska, B. Amendola, A. Wolf, S. Coy, L. Blach, F. Mesfin, D. Suki, G. Rao, V. A. R. Palkonda, N. More, P. Ganesan, R. Kesavan, M. Shunmugavel, T. Kasirajan, V. R. Maram, S. Kakkar, P. Upadhyay, S. Das, S. Nigudgi, J. S. Katz, M. Ghaly, M. Schulder, R. B. Taylor, P. E. Schaner, A. F. Dragovic, J. M. Markert, B. L. Guthrie, M. C. Dobelbower, S. A. Spencer, J. B. Fiveash, L. Chen, H. Guerrero-Cazares, E. Ford, A. Quinones-Hinojosa, K. Redmond, A. G. Wernicke, K. C. Chao, D. Nori, B. Parashar, M. Yondorf, J. A. Boockvar, S. Pannullo, P. Stieg, T. H. Schwartz, J. E. Leeman, D. A. Clump, J. C. Flickinger, S. A. Burton, A. H. Mintz, D. E. Heron, S. H. O'Neil, K. Wong, C. Buranahirun, B. Gonzalez-Morkos, R. J. Brown, A. Hamilton, J. Malvar, R. Sposto, G. Dhall, J. Finlay, A. Olch, K. Reddy, D. Damek, L. Gaspar, D. Ney, B. Kavanagh, A. Waziri, K. Lillehei, K. Stuhr, C. Chen, K. Kalakota, O. Offor, R. Patel, R. Dess, A. Schumacher, I. Helenowski, M. Marymont, P. Sperduto, S. J. Chmura, M. Mehta, G. Zadeh, W. Shi, H. Liu, M. Studenski, L. Fu, C. Peng, V. Gunn, S. Rudoler, C. Farrell, D. Andrews, J. Chu, J. Turian, J. W. Rooney, J. A. B. Ramiscal, N. N. Laack, K. Shah, M. Surucu, E. Melian, D. Anderson, V. Prabhu, T. Origitano, A. Sethi, and B. Emami
Subjects: Oncology, Radiation therapy, Abstracts, Cancer Research, medicine.medical_specialty, Text mining, business.industry, Internal medicine, medicine.medical_treatment, medicine, Neurology (clinical), business
Published: 2012
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10. EPENDYMOMA

Author: M. Zaghloul, M. Elbeltagy, A. Mousa, E. Eldebawy, A. Amin, Z. Pavelka, V. Vranova, I. Valaskova, L. Tomasikova, A. Oltova, J. Ventruba, Z. Mackerle, L. Kren, J. Skotakova, K. Zitterbart, J. Sterba, T. Milde, S. Kleber, A. Korshunov, H. Witt, T. Hielscher, P. Koch, H.-G. Koch, M. Jugold, H. E. Deubzer, I. Oehme, M. Lodrini, H.-J. Grone, A. Benner, O. Brustle, R. J. Gilbertson, A. von Deimling, A. E. Kulozik, S. M. Pfister, M.-V. Ana, O. Witt, M. Kool, S. C. Mack, M. D. Taylor, F. Fouyssac, E. Schmitt, L. Mansuy, J.-C. Marchal, L. Coffinet, V. Bernier, P. Chastagner, D. Sperl, S. Zacharoulis, M. Massimino, E. Schiavello, B. Pizer, C. Piette, L. Kitanovski, K. von Hoff, F. Quehenberger, S. Rutkowski, M. Benesch, T.-D. Tzaridis, S. Bender, E. Pfaff, S. Barbus, J. Bageritz, D.-T.-W. Jones, A. Kulozik, P. Lichter, S.-M. Pfister, S.-H. Song, C.-W. Kang, S.-H. Kim, P. Bandopadhayay, N. Ullrich, L. Goumnerova, R. M. Scott, V. M. Silvera, K. L. Ligon, K. J. Marcus, N. Robison, P. E. Manley, S. Chi, M. W. Kieran, V. Biassoni, P. Pierani, S. Cesaro, M. Maura, S. Mack, N. Jager, D. T. W. Jones, A. Stutz, P. A. Northcott, D. W. Fults, N. Gupta, M. Karajannis, J. T. Rutka, J. Korbel, A. C. P. de Rezende, M. J. Chen, N. S. da Silva, A. Cappellano, S. Cavalheiro, E. Weltman, S. Currle, R. Thiruvenkatam, M. Murugesan, T. Kranenburg, T. Phoenix, K. Gupta, R. Gilbertson, H. Rogers, J.-P. Kilday, C. Mayne, J. Ward, M. Adamowicz-Brice, E. Schwalbe, S. Clifford, B. Coyle, R. Grundy, B. Mitra, C. Domerg, F. Andreiuolo, T. Osteso-Ibanez, A. Mauguen, P. Varlet, M.-C. Le Deley, J. Lowe, D. W. Ellison, J. Grill, R. G. Grundy, G. Fleischhack, K. Pajtler, M. Zimmermann, M. Warmuth-Metz, R.-D. Kortmann, T. Pietsch, A. Faldum, U. Bode, L. Gandola, E. Pecori, G. Scarzello, S. Barra, M. Mascarin, S. Scoccianti, A. Mussano, M. L. Garre, S. Jacopo, E. Viscardi, R. Balter, D. Bertin, F. Giangaspero, M. Pearlman, S. Khatua, T. Van Meter, D. Koul, A. Yung, A. Paulino, J. Su, R. Dauser, W. Whitehead, B. Teh, M. Chintagumpala, D. Perek, M. Drogosiewicz, I. Filipek, M. P. Polnik, B. D. Baginska, J. Wachowiak, B. Kazmierczak, G. Sobol, K. Musiol, J. Kowalczyk, H. W. Slusarz, J. Peregud-Pogorzelski, W. Grajkowska, M. Roszkowski, W.-Y. Teo, F. Okcu, A. Mahajan, A. Adesina, A. Jea, R. Bollo, A. C. Paulino, N. Velez-Char, E. Doerner, A. z. Muehlen, V. Vladimirova, R. Kortmann, C. Friedrich, A. O. von Bueren, M. Barszczyk, P. Buczkowicz, A. Morrison, U. Tabori, C. Hawkins, K. Krajewski, G. Kammler, A. von Bueren, J. Krauss, C. Ferreira, G. Dieffenbach, C. Barbosa, P. Cuny, E. Piccinin, M. Brenca, E. Lorenzetto, I. Sardi, L. Genitori, B. Pollo, R. Maestro, P. Modena, S. MacDonald, D. Ebb, B. Lavally, B. Yeap, K. Marcus, N. Tarbell, T. Yock, S. Schittone, A. Donson, D. Birks, V. Amani, A. Griesinger, M. Handler, M. Madey, T. Merchant, N. Foreman, J. Hukin, T. Ailon, C. Dunham, A.-S. Carret, P. D. McNeely, S. Zelcer, B. Wilson, L. Lafay-Cousin, D. Johnston, D. Eisenstat, M. Silva, N. Jabado, S. Yip, K. Goddard, C. Fryer, G. Hendson, S. Dunn, A. Singhal, Y. Lassen-Ramshad, A. Vestergaard, K. Seiersen, H. P. Schultz, M. Hoeyer, J. B. Petersen, L. Moreno, S. Popov, A. Jury, S. Al Sarraj, C. Jones, D. Bowers, L. Gargan, C. J. Horton, D. Rakheja, L. Margraf, J. Yeung, R. Hamilton, H. Okada, R. Jakacki, I. Pollack, A. Fleming, C. Saint-Martin, C. Freeman, S. Albrecht, and J.-L. Montes
Subjects: Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published: 2012
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11. BIOLOGY

Author: J. H. Kim, H. B. Song, D. H. Kim, K. D. Park, B. J. Lee, S. Khatua, E. Kalkan, R. Brown, M. Pearlman, T. Vats, L. Abela, G. Fiaschetti, T. Shalaby, E. Grunder, M. Ma, J. Grahlert, M. Baumgartner, U. Siler, N. Nonoguchi, H. Ohgaki, M. Grotzer, J.-i. Adachi, T. Suzuki, K. Fukuoka, T. Yanagisawa, K. Mishima, T. Koga, M. Matsutani, R. Nishikawa, I. Sardi, L. Giunti, C. Bresci, S. Cardellicchio, M. Da Ros, A. M. Buccoliero, S. Farina, M. Arico, L. Genitori, M. Massimino, L. Filippi, A. Erdreich-Epstein, H. Zhou, X. Ren, M. Schur, T. B. Davidson, L. Ji, R. Sposto, S. Asgharzadeh, Y. Tong, E. White, M. Murugesan, B. Nimmervoll, M. Wang, D. Marino, D. Ellison, D. Finkelstein, S. Pounds, D. Malkin, R. Gilbertson, C. Eden, B. Ju, T. Phoenix, H. Poppleton, C. Lessman, M. Taylor, G. la Marca, S. Malvagia, V. Fratoni, M. G. Giovannini, F. Giangaspero, M. Badiali, V. Gleize, S. Paris, L. Moi, S. Elhouadani, A. Arcella, R. Morace, M. Antonelli, F. Buttarelli, K. Mokhtari, M. Sanson, S. Smith, J. Ward, M. Wilson, C. Rahman, F. Rose, A. Peet, D. Macarthur, R. Grundy, R. Rahman, S. Venkatraman, D. Birks, I. Balakrishnan, I. Alimova, P. Harris, P. Patel, N. Foreman, R. Vibhakar, H. Wu, Q. Zhou, D. Wang, G. Wang, D. Dang, E. Pencreach, A. Nguyen, E. Guerin, C. Lasthaus, D. Guenot, N. Entz-Werle, R. Unland, S. Schlosser, N. Farwick, T. Plagemann, G. Richter, H. Juergens, M. Fruehwald, C.-L. Chien, Y.-H. Lee, C.-I. Lin, J.-Y. Hsieh, S.-C. Lin, T.-T. Wong, D. M.-T. Ho, H.-W. Wang, S. Lagah, I.-L. Tan, S. Malcolm, Y. Majani, D. G. van Vuurden, E. Aronica, L. E. Wedekind, E. Hulleman, D. Biesmans, M. Bugiani, W. P. Vandertop, G. J. L. Kaspers, T. Wurdinger, D. P. Noske, P. M. Van der Stoop, S. Shukla, G. K. Kuipers, B. J. Slotman, J. Cloos, T. Sun, N. Warrington, J. Luo, S. Ganzhorn, U. Tabori, T. Druley, D. Gutmann, J. Rubin, P. Castelo-Branco, S. Choufani, S. Mack, D. Galagher, C. Zhang, T. Lipman, N. Zhukova, D. Martin, D. Merino, J. Wasserman, C. Samuel, N. Alon, J. Hitzler, J. C. Y. Wang, G. Keller, P. B. Dirks, S. Pfister, M. D. Taylor, R. Weksberg, P. Leblond, S. Meignan, A. Dewitte, F. Le Tinier, N. Wattez, E. Lartigau, A. Lansiaux, R. Hanson, I. Gordon, S. Zhao, K. Camphausen, K. Warren, N. M. Warrington, D. H. Gutmann, J. B. Rubin, M. Jaillet, Z. Kovacs, E. Martin-Fiori, M. Bernasconi, B. Werner, C. Dyberg, N. Baryawno, J. Milosevic, M. Wickstrom, P. A. Northcott, M. Kool, P. Kogner, J. I. Johnsen, G. Reynolds, N. Davies, T. Arvanitis, A. Zoghbi, M. Meisterernst, M. C. Fruehwald, K. Kerl, B. Orr, M. Haffner, W. Nelson, S. Yegnasubramanian, C. Eberhart, A. Fotovati, S. Abu-Ali, P.-S. Wang, L. Deleyrolle, C. Lee, J. Triscott, J. Chen, S. Franciosi, Y. Nakamura, Y. Sugita, T. Uchiumi, M. Kuwano, B. Leavitt, S. Singh, A. Jury, C. Jones, H. Wakimoto, B. Reynolds, C. Pallen, S. Dunn, S. Fletcher, J. Levine, M. Li, N. Kagawa, R. Hirayama, Y. Chiba, N. Kijima, H. Arita, M. Kinoshita, N. Hashimoto, S. Izumoto, M. Maruno, and T. Yoshimine
Subjects: Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published: 2012
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12. Neuro-cognitive

Author: S. H. O'Neil, J. Azoff, C. Buranahirun, G. Dhall, A. Panigrahy, M. Borchert, S. Khatua, L. Ji, R. Sposto, J. Finlay, X. Gong, P. Schwartz, M. Linskey, D. A. Bota, J. S. Wefel, S. Y. Patwardhan, C. Strange, F. Emily, A. Celine, K. Penelope, C. Anne-Sophie, D. M. Rolando, P. Michael, D. D. Correa, W. Shi, L. Abrey, L. DeAngelis, H. Thaler, E. J. Habets, R. Walchenbach, A. Kloet, H. Zwinkels, M. Klein, C. J. Vecht, M. J. Taphoorn, N. Ambachtsheer, D. van Nieuwenhuizen, J. J. Heimans, J. C. Reijneveld, S. M. Peerdeman, C. Lagemaat, K. B. Peters, D. A. Reardon, J. J. Vredenburgh, A. Desjardins, H. S. Friedman, P. H. Driever, E. Koustenis, G. Henze, L. De Sonneville, S. M. Rueckriegel, K. Mok, D. Klein, R. Del Maestro, K. Petrecca, A. Olivier, B. D. Schanker, W. T. Curry, K. Edelstein, B. J. Spiegler, S. Fung, T. Panzarella, D. C. Hodgson, D. J. Mabbott, N. Laperriere, U. Tabori, E. Bouffet, and W. P. Mason
Subjects: Cancer Research, Oncology, Neurology (clinical)
Published: 2010
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13. Radiology

Author: B. M. Ellingson, W. B. Pope, A. Lai, P. L. Nghiemphu, T. F. Cloughesy, C. Juhasz, S. Mittal, O. Muzik, D. C. Chugani, P. K. Chakraborty, G. Bahl, G. R. Barger, J. A. Carrillo, P. Nghiemphu, A. Tran, P. Moftakhar, C. Bruggers, K. Moore, S. Khatua, M. K. Gumerlock, E. Stolzenberg, K.-M. Fung, M. L. Smith, K. Kedzierska, G. Chacko, R. B. Epstein, J. Holter, R. Parvataneni, A. Kadambi, I. Park, A. Elkhaled, E. Essock-Burns, I. Khayal, N. Butowski, K. Lamborn, S. Chang, S. Nelson, E. Sanverdi, B. Ozgen, K. K. Oguz, F. Soylemezoglu, M. Mut, J.-J. Zhu, R. Pfannl, D. Do-Dai, K. Yao, J. Mignano, J. K. Wu, N. Linendoll, K. Beal, T. Chan, Y. Yamamda, A. Holodny, P. H. Gutin, Z. Zhang, R. J. Young, J. M. Lupo, S. Cha, S. M. Chang, S. J. Nelson, N. Laperriere, J. Perry, D. Macdonald, W. Mason, J. Easaw, R. Del Maestro, W. Kucharczyk, D. Hussey, K. Greaves, S. Moore, J.-F. Pouliot, P. K. Rauschkolb, S. D. Smith, C. J. Belden, E. C. Lallana, C. E. Fadul, L. Bosscher, M. Slot, E. Sanchez, B. M. Uitdehaag, W. P. Vandertop, S. M. Peerdeman, D. T. Blumenthal, F. Bokstein, M. Artzi, M. Palmon, O. Aizenstein, R. Sitt, K. Gurevich, A. Kanner, Z. Ram, B. Corn, D. Ben Bashat, N. Martinez, R. Gorniak, L. Tartaglino, M. Scanlan, J. Glass, A. Kleijn, J. W. Chen, P. Z. Sun, J. Buhrman, S. D. Rabkin, R. Weissleder, R. L. Martuza, M. L. Lamfers, G. Fulci, K. A. Brong, K. Hekmatyar, N. Jerome, M. Wilson, R. A. Kauppinen, K. Mok, M. M. Valenca, E. Sherafat, A. Olivier, E. Pentsova, M. Rosenblum, L. Palomba, A. Omuro, G. J. Murad, A. T. Yachnis, E. M. Dunbar, Y. Li, J. Lupo, M.-Y. Polley, N. Kohler, R. Quisling, K. R. Swanson, S. Gu, G. Chakraborty, A. Alessio, J. Claridge, R. C. Rockne, M. Muzi, K. A. Krohn, A. M. Spence, E. C. Alvord, A. R. Anderson, P. Kinahan, A. E. Boone, M. M. Mrugala, M. Gutova, V. Khankaldyyan, K. A. Herrmann, I. Harutyunyan, Y. Abramyants, A. J. Annala, J. Najbauer, R. A. Moats, G. M. Shackleford, M. E. Barish, and K. S. Aboody
Subjects: Cancer Research, Oncology, Neurology (clinical)
Published: 2010
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14. Estimation of Self-Injection Length in Heterostructures of YBa2Cu3O7-δ Superconductor and La0.67Ca0.33MnO3 Manganite

Author: C.M. Thakar, S. Wanchoo, T. Bannerjee, S.K. Malik, and S. Khatua
Subjects: Length scale, Superconductivity, Materials science, Condensed matter physics, Spintronics, Magnetism, General Materials Science, Heterojunction, Condensed Matter Physics, Epitaxy, Manganite, Atomic and Molecular Physics, and Optics, Pulsed laser deposition
Abstract: Epitaxial bilayers of YBa2Cu3O7-δ (YBCO) and La0.67Ca0.33MnO3 (LCMO) heterostructures have been prepared by pulsed laser deposition technique, the growth sequence being YBCO on LCMO. The length scale of the YBCO layer, which is rendered non-superconductor/insulator by selfinjection of the spin polarized quasiparticles, is estimated to be 850Å. This can be an important guiding parameter in spintronic device configuration/fabrication.
Published: 2006
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15. Metastasis from cervical carcinoma presenting with acute intestinal obstruction a case report

Author: S Khatua, Uma Banerjee, Manish Nigam, and Soma Datta
Subjects: medicine.medical_specialty, Hysterectomy, business.industry, medicine.medical_treatment, General Medicine, medicine.disease, Metastasis, Surgery, Gross examination, medicine.anatomical_structure, Cervical carcinoma, medicine, Mesenteric lymph nodes, Presentation (obstetrics), business, Cervix, Lymph node
Abstract: A 55 yr. old woman attended emergency with acute intestinal obstruction. The patient underwent emergency surgical procedure of intestinal resection after straight X-ray,few haematological and biochemical investigations. On gross examination ileal stricture due to mass in ileocaecal region with mesenteric lymph nodes found which on histological examination came out to be a squamous cell carcinoma with metastatic deposit in lymph node. The patient had a hysterectomy done 3&1/2 years back for Stage IIB squamous cell carcinoma of cervix for which she received chemoradiation.The intestinal obstruction very likely to be a metastatic presentation. DOI: http://dx.doi.org/10.3329/bjms.v12i4.16666 Bangladesh Journal of Medical Science Vol. 12 No. 04 October 13 Page 439-441
Published: 2013
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16. RADIATION ONCOLOGY

Author: B. Kunheri, A. Arjunan, P. Krishnan, B. Pillai, S. Prasad, V. Bernier-Chastagner, E. Desandes, C. Carrie, C. Alapetite, T. Hankinson, D. Jones, M. Handler, N. Foreman, A. Liu, N. P. Smiley, T. Alden, W. Hartsell, J. Fangusaro, C. E. Hill-Kayser, R. A. Lustig, J. E. Minturn, S. Both, A. J. Waanders, J. B. Belasco, C. Armstrong, P. C. Phillips, M. J. Fisher, I. Paltin, K. A. Cole, E. Wells, G. Vezina, L. Kilburn, B. Rood, F. Crozier, E. Hwang, R. Packer, G. O. Janssens, S. van den Bosch, P. G. van Kollenburg, C. E. Gidding, J. H. Schieving, J. H. Kaanders, E. J. van Lindert, K. Kramer, N. Pandit-Taskar, M. M. Souweidane, S. Wolden, C. DeSelm, N.-K. V. Cheung, Y. Lassen-Ramshad, J. Hansen, K. Seiersen, J. B. B. Petersen, A. Mahajan, D. Grosshans, D. Ris, M. Chintagumpala, F. Okcu, M. F. McAleer, B. Moore, H. Stancel, C. Minard, D. Guffey, L. Kahalley, K. Blomgren, K. Zhou, C. Xie, C. Zhu, Z. Zhao, J. Weinberg, D. Sandberg, D. Hughes, P. Anderson, N. Guha-Thakurta, K. Muller, M. Hoffmann, C. Seidel, M. Warmuth-Metz, T. Pietsch, U. Kordes, A. Sander, J. Rossler, N. Graf, H. Scheithauer, R.-D. Kortmann, C. M. Kramm, A. O. von Bueren, J. Gunther, M. Sato, E. Jo, A. Paulino, A. Adesina, L. Ketonen, J. Jones, J. Su, S. Khatua, R. Dauser, W. Whitehead, L. Gandola, E. Pecori, V. Biassoni, C. Chiruzzi, E. Schiavello, S. Meroni, F. Spreafico, E. Pignoli, M. Massimino, R. Jalali, U. Krishna, T. Gupta, S. Goswami, J. Deodhar, D. Dutta, S. Kannan, A. Goel, R. Sarin, J. Sastry, M. Ronghe, D. Murphy, K. Forbes, R. Jones, F. Cowie, J. Brown, D. Indelicato, E. O. Goksel, E. Tezcanli, H. Bilge, null Yasemin, Y. Yarar, M. Okcu, M. F. Okcu, A. Danielsson, M. Tisell, B. Rydenhag, and H. Caren
Subjects: Cancer Research, Abstracts, Oncology, business.industry, Medicine, Neurology (clinical), Irradiation, Nuclear medicine, business
Published: 2014

17. TUMOUR BIOLOGY

Author: T. Geller, V. Prakash, J. Batanian, M. Guzman, E. Duncavage, T. Gershon, A. Crowther, J. Wu, H. Liu, F. Fang, I. Davis, D. Tripolitsioti, M. Ma, K. Kumar, J. Grahlert, K. Egli, G. Fiaschetti, T. Shalaby, M. Grotzer, M. Baumgartner, M. Braoudaki, G. I. Lambrou, K. Giannikou, V. Millionis, S. A. Papadodima, N. Settas, G. Sfakianos, K. Stefanaki, A. Kattamis, C. A. Spiliopoulou, F. Tzortzatou-Stathopoulou, E. Kanavakis, S. Gholamin, S. Mitra, A. Feroze, M. Zhang, R. Esparza, S. Kahn, C. Richard, A. Achrol, A. Volkmer, J. Liu, J. Volkmer, R. Majeti, I. Weissman, S. Cheshier, K. Bhatia, N. Brown, J. Teague, P. Lo, J. Challis, V. Beshay, M. Sullivan, F. Mechinaud, J. Hansford, M. Z. Arifin, R. H. Dahlan, M. Sobana, P. Saputra, M. T. Tisell, A. Danielsson, H. Caren, R. Bhardwaj, M. Chakravadhanula, C. Hampton, V. Ozals, J. Georges, W. Decker, V. Kodibagkar, A. Nguyen, M. Legrain, M. P. Gaub, E. Pencreach, M. P. Chenard, D. Guenot, N. Entz-Werle, Y. Kanemura, K. Ichimura, T. Shofuda, R. Nishikawa, M. Yamasaki, S. Shibui, H. Arai, J. Xia, A. Brian, R. Prins, C. Pennell, C. Moertel, M. Olin, L. Bie, X. Zhang, M. Olsson, T. Kling, S. Nelander, V. Biassoni, I. Bongarzone, P. Verderio, M. Massimino, R. Magni, S. Pizzamiglio, C. Ciniselli, E. Taverna, M. De Bortoli, A. Luchini, L. Liotta, E. Barzano, F. Spreafico, E. Visse, E. Sanden, A. Darabi, P. Siesjo, S. Jackson, K. Cohen, D. Lin, P. Burger, F. Rodriguez, X. Yao, R. Liucheng, L. Qin, T. Na, W. Meilin, Z. Zhengdong, F. Yongjun, S. Pfeifer, M. Nister, T. D. de Stahl, E. Basmaci, E. Orphanidou-Vlachou, M.-A. Brundler, Y. Sun, N. Davies, M. Wilson, X. Pan, T. Arvanitis, R. Grundy, A. Peet, C. Eden, B. Ju, T. Phoenix, B. Nimmervoll, Y. Tong, D. Ellison, C. Lessman, M. Taylor, R. Gilbertson, V. Folgiero, F. del Bufalo, A. Carai, M. G. Cefalo, A. Citti, S. Rutella, F. Locatelli, A. Mastronuzzi, O. Maher, S. Khatua, W. Zaky, A. Lourdusamy, L. Meijer, R. Layfield, D. T. W. Jones, D. Capper, M. Sill, V. Hovestadt, L. Schweizer, P. Lichter, D. Zagzag, M. A. Karajannis, K. D. Aldape, A. Korshunov, A. von Deimling, S. Pfister, A. Chakrabarty, R. Feltbower, E. Sheridon, H. Hassan, M. Shires, S. Picton, K. Hatziagapiou, F. Tsorteki, K. Bethanis, V. Gemou-Engesaeth, S. N. Chi, P. Bandopadhayay, K. Janeway, N. Pinches, H. Malkin, M. W. Kieran, P. E. Manley, A. Green, L. Goumnerova, S. Ramkissoon, M. H. Harris, K. L. Ligon, U. Kahlert, M. Suarez, J. Maciaczyk, E. Bar, C. Eberhart, R. Kenchappa, N. Krishnan, P. Forsyth, B. McKenzie, A. Pisklakova, G. McFadden, W. Pan, L. Rodriguez, J. Glod, J. M. Levy, J. Thompson, A. Griesinger, V. Amani, A. Donson, D. Birks, M. Morgan, M. Handler, N. Foreman, A. Thorburn, R. R. Lulla, J. Laskowski, J. Fangusaro, A. J. DiPatri, T. Alden, T. Tomita, E. F. Vanin, S. Goldman, M. B. Soares, M. Remke, V. Ramaswamy, X. Wang, F. Jorgensen, A. S. Morrissy, M. Marra, R. Packer, E. Bouffet, N. Jabado, B. Cole, E. Rudzinski, M. Anderson, K. Bloom, A. Lee, S. Leary, G. Leprivier, B. Rotblat, S. Agnihotri, M. Kool, B. Derry, M. D. Taylor, P. H. Sorensen, T. Dobson, E. Busschers, H. Taylor, R. Hatcher, R. Lulla, V. Rajaram, C. Das, and V. Gopalakrishnan
Subjects: Cancer Research, Abstracts, Oncology, Neurology (clinical)
Published: 2014

18. HIGH GRADE GLIOMAS AND DIPG

Author: C. F. Classen, D. William, M. Linnebacher, A. Farhod, W. Kedr, B. Elsabe, S. Fadel, S. Van Gool, S. De Vleeschouwer, C. Koks, A. Garg, M. Ehrhardt, M. Riva, P. Agostinis, N. Graf, T.-W. Yao, Y. Yoshida, J. Zhang, T. Ozawa, D. James, T. Nicolaides, R. Kebudi, F. B. Cakir, O. Gorgun, F. Y. Agaoglu, E. Darendeliler, A. Al-Kofide, E. Al-Shail, Y. Khafaga, H. Al-Hindi, M. Dababo, A. U. Haq, M. Anas, M. G. Barria, K. Siddiqui, M. Hassounah, M. Ayas, S. V. van Zanten, M. Jansen, D. van Vuurden, M. Huisman, D. Vugts, O. Hoekstra, G. van Dongen, G. Kaspers, J. Cockle, E. Ilett, K. Scott, A. Bruning-Richardson, S. Picton, S. Short, A. Melcher, M. Benesch, M. Warmuth-Metz, A. O. von Bueren, M. Hoffmann, T. Pietsch, R.-D. Kortmann, M. Eyrich, S. Rutkowski, M. C. Fruhwald, J. Faber, C. Kramm, M. Porkholm, L. Valanne, T. Lonnqvist, S. Holm, B. Lannering, P. Riikonen, D. Wojcik, A. Sehested, N. Clausen, A. Harila-Saari, E. Schomerus, H. K. Thorarinsdottir, P. Lahteenmaki, M. Arola, H. Thomassen, U. M. Saarinen-Pihkala, S.-M. Kivivuori, P. Buczkowicz, C. Hoeman, P. Rakopoulos, S. Pajovic, A. Morrison, E. Bouffet, U. Bartels, O. Becher, C. Hawkins, T. W. A. Gould, C. V. Rahman, S. J. Smith, D. A. Barrett, K. M. Shakesheff, R. G. Grundy, R. Rahman, N. Barua, D. Cronin, S. Gill, S. Lowisl, A. Hochart, C.-A. Maurage, N. Rocourt, M. Vinchon, O. Kerdraon, F. Escande, J. Grill, V. K. Pick, P. Leblond, G. Burzynski, T. Janicki, S. Burzynski, A. Marszalek, N. Ramani, W. Zaky, G. Kannan, A. Morani, D. Sandberg, L. Ketonen, O. Maher, F. Corrales-Medina, H. Meador, S. Khatua, M. Brassesco, L. Delsin, G. Roberto, C. Silva, L. Ana, E. Rego, C. Scrideli, K. Umezawa, L. Tone, S. J. Kim, C.-Y. Kim, I.-A. Kim, J. H. Han, B.-S. Choi, H. S. Ahn, H. S. Choi, F. Haque, R. Layfield, R. Grundy, L. Gandola, E. Pecori, V. Biassoni, E. Schiavello, C. Chiruzzi, F. Spreafico, P. Modena, F. Bach, E. Pignoli, M. Massimino, M. Drogosiewicz, B. Dembowska-Baginska, E. Jurkiewicz, I. Filipek, M. Perek-Polnik, E. Swieszkowska, D. Perek, S. Bender, D. T. Jones, H.-J. Warnatz, B. Hutter, T. Zichner, J. Gronych, A. Korshunov, R. Eils, J. O. Korbel, M.-L. Yaspo, P. Lichter, S. M. Pfister, S. Yadavilli, O. J. Becher, M. Kambhampati, R. J. Packer, J. Nazarian, F. C. Lechon, L. Fowkes, K. Khabra, L. M. Martin-Retortillo, L. V. Marshall, S. Vaidya, D.-M. Koh, M. O. Leach, A. D. Pearson, S. Zacharoulis, D. Schrey, G. Barone, E. Panditharatna, M. Stampar, A. Siu, H. Gordish-Dressman, J. Devaney, E. I. Hwang, A. H. Chung, R. K. Mittapalli, W. F. Elmquist, D. Castel, M.-A. Debily, C. Philippe, N. Truffaux, K. Taylor, R. Calmon, N. Boddaert, L. Le Dret, P. Saulnier, L. Lacroix, A. Mackay, C. Jones, S. Puget, C. Sainte-Rose, T. Blauwblomme, P. Varlet, N. Entz-Werle, C. Maugard, G. Bougeard, A. Nguyen, M. P. Chenard, A. Schneider, M. P. Gaub, M. Tsoli, A. Vanniasinghe, P. Luk, P. Dilda, M. Haber, P. Hogg, D. Ziegler, S. Simon, M. Monje, K. Gurova, A. Gudkov, M. Zapotocky, M. Churackova, B. Malinova, J. Zamecnik, M. Kyncl, M. Tichy, A. Puchmajerova, J. Stary, D. Sumerauer, J. Boult, M. Vinci, L. Perryman, G. Box, A. Jury, S. Popov, W. Ingram, S. Eccles, S. Robinson, S. Emir, H. A. Demir, C. Bayram, F. Cetindag, G. B. Kabacam, A. Fettah, J. Li, Y. Jamin, C. Cummings, J. Bamber, R. Sinkus, M. Nandhabalan, L. Bjerke, A. Burford, A. von Bueren, M. Baudis, P. Clarke, I. Collins, P. Workman, N. Olaciregui, J. Mora, A. Carcaboso, A. Bullock, M. Alonso, C. de Torres, O. Cruz, E. Pencreach, F. M. Moussalieh, D. Guenot, I. Namer, I. Pollack, R. Jakacki, L. Butterfield, R. Hamilton, A. Panigrahy, D. Potter, A. Connelly, S. Dibridge, T. Whiteside, H. Okada, S. Ahsan, E. Raabe, M. Haffner, K. Warren, M. Quezado, L. Ballester, C. Eberhart, F. Rodriguez, C. Ramachandran, S. Nair, K.-W. Quirrin, Z. Khatib, E. Escalon, S. Melnick, M. Hofmann, I. Schmid, T. Simon, E. Maass, A. Russo, G. Fleischhack, M. Becker, H. Hauch, A. Sander, C. Grasso, N. Berlow, L. Liu, L. Davis, E. Huang, P. Woo, Y. Tang, A. Ponnuswami, S. Chen, Y. Huang, M. Hutt-Cabezas, L. Dret, P. Meltzer, H. Mao, J. Abraham, M. Fouladi, M. N. Svalina, N. Wang, E. Hulleman, X.-N. Li, C. Keller, P. T. Spellman, R. Pal, M. H. A. Jansen, A. C. P. Sewing, T. Lagerweij, D. J. Vuchts, D. G. van Vuurden, V. Caretti, P. Wesseling, G. J. L. Kaspers, K. Cohen, M. Pearl, M. Kogiso, L. Zhang, L. Qi, H. Lindsay, F. Lin, S. Berg, J. Muscal, N. Amayiri, U. Tabori, B. Campbel, D. Bakry, M. Aronson, C. Durno, S. Gallinger, D. Malkin, I. Qaddumi, A. Musharbash, M. Swaidan, M. Al-Hussaini, S. Shandilya, C. McCully, R. Murphy, S. Akshintala, D. Cole, R. P. Macallister, R. Cruz, B. Widemann, R. Salloum, A. Smith, M. Glaunert, A. Ramkissoon, S. Peterson, S. Baker, L. Chow, J. Sandgren, S. Pfeifer, S. Popova, I. Alafuzoff, T. D. de Stahl, S. Pietschmann, M. J. Kerber, I. Zwiener, G. Henke, K. Muller, N. Y.-F. Sieow, R. H. M. Hoe, A. M. Tan, M. Y. Chan, S. Y. Soh, K. Burrell, Y. Chornenkyy, M. Remke, B. Golbourn, M. Barzczyk, M. Taylor, J. Rutka, P. Dirks, G. Zadeh, S. Agnihotri, R. Hashizume, Y. Ihara, N. Andor, X. Chen, R. Lerner, X. Huang, M. Tom, D. Solomon, S. Mueller, C. Petritsch, Z. Zhang, N. Gupta, T. Waldman, A. Dujua, J. Co, F. Hernandez, D. Doromal, M. Hegde, A. Wakefield, V. Brawley, Z. Grada, T. Byrd, K. Chow, S. Krebs, H. Heslop, S. Gottschalk, E. Yvon, N. Ahmed, G. Cornilleau, J. Paulsson, F. Andreiuolo, L. Guerrini-Rousseau, B. Geoerger, G. Vassal, A. Ostman, D. W. Parsons, L. R. Trevino, F. Gao, X. Shen, O. Hampton, M. Kosigo, P. A. Baxter, J. M. Su, M. Chintagumpala, R. Dauser, A. Adesina, S. E. Plon, D. A. Wheeler, C. C. Lau, G. Gielen, A. z. Muehlen, R. Kwiecien, J. Wolff, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, J. Fangusaro, M. Kieran, A. Fontebasso, S. Papillon-Cavanagh, J. Schwartzentruber, H. Nikbakht, N. Gerges, P.-O. Fiset, D. Bechet, D. Faury, N. De Jay, L. Ramkissoon, A. Corcoran, D. Jones, D. Sturm, P. Johann, T. Tomita, M. Nagib, A. Bendel, L. Goumnerova, D. C. Bowers, J. R. Leonard, J. B. Rubin, T. Alden, A. DiPatri, S. Browd, S. Leary, G. Jallo, M. D. Prados, A. Banerjee, A.-S. Carret, B. Ellezam, L. Crevier, A. Klekner, L. Bognar, P. Hauser, M. Garami, J. Myseros, Z. Dong, P. M. Siegel, W. Gump, K. Ayyanar, J. Ragheb, M. Krieger, E. Kiehna, N. Robison, D. Harter, S. Gardner, M. Handler, N. Foreman, B. Brahma, T. MacDonald, H. Malkin, S. Chi, P. Manley, P. Bandopadhayay, L. Greenspan, A. Ligon, S. Albrecht, K. L. Ligon, J. Majewski, N. Jabado, F. Cordero, K. Halvorson, I. Taylor, M. Hutt, M. Weingart, A. Price, M. Kantar, S. Onen, S. Kamer, T. Turhan, O. Kitis, Y. Ertan, N. Cetingul, Y. Anacak, T. Akalin, Y. Ersahin, G. Mason, C. Ho, F. Crozier, G. Vezina, R. Packer, E. Hwang, S. Gilheeney, N. Millard, K. DeBraganca, Y. Khakoo, K. Kramer, S. Wolden, M. Donzelli, C. Fischer, M. Petriccione, I. Dunkel, S. Afzal, A. Fleming, V. Larouche, S. Zelcer, D. L. Johnston, M. Kostova, C. Mpofu, J.-C. Decarie, D. Strother, L. Lafay-Cousin, D. Eisenstat, C. Fryer, J. Hukin, M. Hsu, J. Lasky, T. Moore, L. Liau, T. Davidson, R. Prins, T. Hassal, J. Baugh, J. Kirkendall, R. Doughman, J. Leach, B. Jones, L. Miles, D. Hargrave, T. Jacques, S. Savage, D. Saunders, R. Wallace, B. Flutter, D. Morgenestern, E. Blanco, K. Howe, M. Lowdell, E. Samuel, A. Michalski, J. Anderson, Y. Arakawa, K. Umeda, K.-i. Watanabe, T. Mizowaki, M. Hiraoka, H. Hiramatsu, S. Adachi, T. Kunieda, Y. Takagi, S. Miyamoto, S. Venneti, M. Santi, M. M. Felicella, L. M. Sullivan, I. Dolgalev, D. Martinez, A. Perry, P. W. Lewis, D. C. Allis, C. B. Thompson, and A. R. Judkins
Subjects: Oncology, Cancer Research, medicine.medical_specialty, business.industry, 03 medical and health sciences, Abstracts, 0302 clinical medicine, Text mining, 030220 oncology & carcinogenesis, Internal medicine, medicine, Neurology (clinical), business, 030217 neurology & neurosurgery
Published: 2014

19. RARE TUMOURS

Author: E. Panosyan, M. Gotesman, T. Kallay, S. Martinez, M. Bolaris, J. Lasky, F. Fouyssac, J.-C. Gentet, D. Frappaz, C. Piguet, S. Gorde-Grosjean, J. Grill, E. Schmitt, S. Pall-Kondolff, P. Chastagner, R. Dudley, M. Torok, D. Gallegos, A. Liu, M. Handler, T. Hankinson, K. Fukuoka, T. Yanagisawa, T. Suzuki, M. Shirahata, J.-i. Adachi, K. Mishima, T. Fujimaki, M. Matsutani, A. Sasaki, S. Wada, R. Nishikawa, M. Suzuki, A. Kondo, M. Miyajima, H. Arai, S. Morin, E. Uro-Coste, C. Munzer, M. Gambart, S. Puget, C. Miquel, C.-A. Maurage, C. Dufour, P. Leblond, N. Andre, J. Kanold, C. Icher, A.-a. I. Bertozzi, B. Diez, A. Muggeri, S. Cerrato, B. Calabrese, N. Arakaki, A. Marron, G. Sevlever, M. J. Fisher, B. C. Widemann, E. Dombi, P. Wolters, A. Cantor, A. Vinks, J. Parentesis, N. Ullrich, D. Gutmann, D. Viskochil, J. Tonsgard, B. Korf, R. Packer, B. Weiss, L. Marcus, A. Kim, A. Baldwin, P. Whitcomb, S. Martin, A. Gillespie, A. Doyle, C. Bulwer, H.-W. Gan, A. Ederies, M. Korbonits, M. Powell, O. Jeelani, T. Jacques, E. Stern, H. Spoudeas, M. Kimpo, J. Tang, C. L. Tan, T. T. Yeo, Q. T. Chong, V. Ruland, S. Hartung, U. Kordes, J. E. Wolff, W. Paulus, M. Hasselblatt, S. Patil, W. Zaky, S. Khatua, Y. Lassen-Ramshad, L. Christensen, N. Clausen, A. Bendel, W. Dobyns, J. Bennett, M. Reyes-Mugica, J. Petronio, M. Nikiforova, H. Mueller, E. Kirches, A. Korshunov, S. Pfister, C. Mawrin, M. Hemenway, N. Foreman, A. Kumar, S. Kalra, R. Acharya, N. Radhakrishnan, A. Sachdeva, B. Nimmervoll, D. Hadjadj, Y. Tong, A. A. Shelat, J. Low, G. Miller, C. F. Stewart, R. K. Guy, R. J. Gilbertson, T. Miwa, Y. Nonaka, S. Oi, H. Sasaki, K. Yoshida, R. Northup, L. Klesse, R. McNall-Knapp, M. Blagia, F. Romeo, S. Toscano, A. D'Agostino, L. Lafay-Cousin, G. Lindzon, E. Bouffet, M. Taylor, W. Hader, R. Nordal, C. Hawkins, N. Laperriere, S. Laughlin, H. Shash, P. McDonald, J. Wrogemann, A. Ahsanuddin, K. Matsuda, R. Soni, M. I. Vanan, K. Cohen, I. Taylor, F. Rodriguez, P. Burger, J. Yeh, S. Rao, B. Iskandar, B. A.- Kienitz, R. Bruce, L. Keller, S. Salamat, D. Puccetti, N. Patel, A. Hana, V. R. N. Gunness, C. Berthold, L. Bofferding, C. Neuhaeuser, E. Scalais, I. Kieffer, W. Feiden, N. Graf, H. Boecher-Schwarz, F. Hertel, O. Cruz, A. Morales, C. de Torres, A. Vicente, M. A. Gonzalez, M. Sunol, J. Mora, G. Garcia, A. Guillen, J. Muchart, M. Yankelevich, S. Sood, J. Diver, S. Savasan, J. Poulik, K. Bhambhani, A. Hochart, V. Gaillard, N.-X. Bonne, M. Baroncini, J.-P. Vannier, F. Dubrulle, J.-P. Lejeune, C. Vincent, A. Japp, M. Gessi, A. z. Muehlen, L. Klein-Hitpass, T. Pietsch, M. Sharma, R. Yadav, P. B. Malgulwar, P. Pathak, E. Sigamani, V. Suri, C. Sarkar, A. Jagdevan, M. Singh, B. S. Sharma, A. Garg, S. Bakhshi, M. Faruq, D. Doromal, C. J. Villafuerte, E. Tezcanli, M. Yilmaz, M. Sengoz, S. Peker, G. Dhall, N. Robison, A. Margol, A. Evans, M. Krieger, J. Finlay, T. Rosser, Y. Khakoo, C. Pratilas, A. Marghoob, M. Berger, T. Hollmann, M. Rosenblum, M. Mrugala, P. Giglio, C. Keene, M. Ferreira, D. Garcia, A. Weil, Z. Khatib, A. Diaz, T. Niazi, S. Bhatia, J. Ragheb, K. Rangan, F. Gilles, C. Morris, Y. Chen, V. Shetty, S. Elbabaa, M. Guzman, M. S. Abdel-Baki, S. Waguespack, J. Jones, S. Stapleton, D. Baskin, null M, and F. Okcu
Subjects: Cancer Research, Abstracts, Oncology, Neurology (clinical)
Published: 2014

20. [Untitled]

Author: Ning Pan, X. S. Zhang, S. Khatua, S. H. Zeronian, J. Thompson, H. C. Chen, and M. K. Inglesby
Subjects: Brittleness, Materials science, Mechanics of Materials, Mechanical Engineering, Solid mechanics, Ultimate tensile strength, Modulus, General Materials Science, Slippage, Gauge (firearms), Strain rate, Composite material, Weibull distribution
Abstract: The size of a fibre affects its mechanical properties and thus is of theoretical and practical importance for studies of the rupturing process during loading of a fibrous structure. This paper investigates the overall effects of length on the mechanical behaviour of single fibres. Four types of fibres, ranging from brittle to highly extensible, were tested for their tensile properties at several different gauge lengths. Different from most previous studies where the focus has been on the gauge length effects on a single property such as fibre strength or breaking strain, this paper look comprehensively into the effects of length on all three of the most commonly studied mechanical properties, namely strength, breaking strain and initial modulus. Particular emphasis is placed on initial modulus and on the interactions between all three parameters. Influences of strain rate and fibre type on the size effects are also investigated. The effect of potential fibre slippage on experimental error is examined. An image analysis method is used to measure the real fibre elongation in comparison to the same fibre elongation obtained directly from an Instron tester. Finally, a statistical analysis is carried out using the experimental data to test the fitness of the Weibull theory to polymeric fibres. This was done as the Weibull model has been extensively utilized in examining fibre strength and breaking strain, although it is supposed to be valid only for the so-called classic fibres to which more extensible polymeric fibres do not belong.
Published: 1997
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21. RADIATION THERAPY

Author: M. Anwar, J. Lupo, A. Molinaro, J. Clarke, N. Butowski, M. Prados, S. Chang, D. HaasKogan, S. Nelson, J. Ashman, J. Drazkowski, R. Zimmerman, T. Lidner, C. Giannini, A. Porter, N. Patel, I. Atean, N. Shin, A. Toltz, C. Laude, C. Freeman, J. Seuntjens, D. Roberge, M. Back, M. Kastelan, L. Guo, H. Wheeler, P. Beauchesne, G. Faure, G. Noel, T. Schmitt, L. Martin, E. Jadaud, C. Carnin, J. Bowers, N. Bennion, H. Lomas, K. Spencer, M. Richardson, W. McAllister, J. Sheehan, D. Schlesinger, R. Kersh, J. Brower, S. Gans, W. Hartsell, S. Goldman, J. H.-C. Chang, N. Mohammed, M. Siddiqui, V. Gondi, E. Christensen, S. Klawikowski, A. Garg, M. McAleer, L. Rhines, J. Yang, P. Brown, E. Chang, S. Settle, A. Ghia, M. Edson, G. N. Fuller, P. Allen, J. Li, A. Garsa, S. Badiyan, J. Simpson, J. Dowling, K. Rich, M. Chicoine, E. Leuthardt, A. Kim, C. Robinson, B. Gill, D. Peskorski, R. Lalonde, M. S. Huq, J. Flickinger, A. Graff, P. Clerkin, H. Smith, R. Isaak, J. Dinh, D. Grosshans, J. de Groot, S. McGovern, M. Gilbert, A. Mahajan, T. Gupta, S. Mohanty, S. Kannan, R. Jalali, J. Hardie, N. Laack, S. Kizilbash, J. Buckner, J. Uhm, I. Parney, R. Jenkins, P. Decker, J. Voss, R. Hiramatsu, S. Kawabata, M. Furuse, S.-I. Niyatake, T. Kuroiwa, M. Suzuki, K. Ono, C. Hobbs, L. Vallow, J. Peterson, K. Jaeckle, M. Heckman, R. Bhupendra, D. Horowitz, C.-S. Wuu, W. Feng, D. Drassinower, A. Lasala, A. Lassman, T. Wang, D. Indelicato, R. Rotondo, J. Bradley, E. Sandler, P. Aldana, N. Mendenhall, R. Marcus, R. Kabarriti, W. F. Mourad, D. M. Mejia, J. Glanzman, S. Patel, R. Young, M. Bernstein, L. Hong, J. Fox, P. LaSala, S. Kalnicki, M. Garg, S. Khatua, P. Hou, J. Wolff, J. Hamilton, W. Zaky, L. Ketonen, S.-H. Kim, S. R. Lee, null Ji, Y. Oh, U. Krishna, N. Shah, R. Pathak, A. Lila, P. Menon, A. Goel, R. Lall, T. Smith, A. Schumacher, A. McCaslin, J. Kalapurakal, J. Chandler, W. Magnuson, H. I. Robins, P. Mohindra, S. Howard, D. Manfredi, C. L. Rogers, M. Palmer, E. Hillebrandt, S. Bilton, G. Robinson, K. Velasco, M. Mehta, J. McGregor, J. Grecula, M. Ammirati, C. Pelloski, L. Lu, N. Gupta, S. Bell, S. Moller, I. Law, P. M. a. Rosenschold, J. Costa, H. S. Poulsen, S. A. Engelholm, A. Morrison, B. Cuglievan, Z. Khatib, T. Santiago, D. M. Blakaj, M. Welch, J. Graber, L. X. Hong, A. Patel, A. Tandon, M. B. Bernstein, R. A. Shourbaji, M. D. Kinon, J. L. Fox, P. Lasala, M. K. Garg, S. Nicholas, R. Salvatori, M. Lim, K. Redmond, A. Quinones, G. Gallia, D. Rigamonti, L. Kleinberg, W. Mourad, R. Yaparpalvi, O. Mian, M. Degaonkar, H. Sair, S. Terezakis, T. McNutt, M. Wharam, M. Mahone, A. Horska, U. Rezvi, E. Melian, M. Surucu, I. Mescioglu, V. Prabhu, J. Clark, D. Anderson, J. Robbins, R. Yechieli, S. Ryu, M. I. Ruge, B. Suchorska, C. Hamisch, K. Mahnkopf, R. Lehrke, H. Treuer, V. Sturm, J. Voges, A. Sahgal, A. Al-Omair, L. Masucci, L. Masson-Cote, E. Atenafu, D. Letourneau, E. Yu, R. Rampersaud, S. Lewis, A. Yee, I. Thibault, M. Fehlings, W. Shi, J. Palmer, L. Kenyon, J. Glass, L. Kim, M. Werner-wasik, D. Andrews, S. Susheela, S. Revannasiddaiah, S. Muzumder, G. Mallarajapatna, A. Basavalingaiah, M. Gupta, K. Kallur, M. Hassan, R. Bilimagga, K. Tamura, M. Aoyagi, N. Ando, T. Ogishima, M. Yamamoto, K. Ohno, T. Maehara, Z. Xu, M. L. Vance, D. Blakaj, P. A. LaSala, J. J. Graber, A. L. Zimmerman, M. A. Vogelbaum, G. H. Barnett, E. S. Murphy, J. H. Suh, L. Angelov, C. A. Reddy, and S. T. Chao
Subjects: Cancer Research, Abstracts, Oncology, Neurology (clinical)
Published: 2013

22. Toward single-molecule spectroscopy on a smart phone

Author: S. Khatua and M. Orrit
Published: 2013

23. Mononuclear bis(dithiolene) Mo(<scp>iv</scp>) and W(<scp>iv</scp>) complexes with P,P; S,S; O,S and O,O donor ligands: a comparative reactivity study

Author: S. Khatua, Amit Majumdar, T. Naskar, and C. Nandi
Subjects: 010405 organic chemistry, Stereochemistry, Chemistry, Materials Chemistry, Reactivity (chemistry), General Chemistry, 010402 general chemistry, 01 natural sciences, Redox, Catalysis, 0104 chemical sciences
Abstract: A new general synthetic strategy for a series of mononuclear bis(maleonitriledithiolato)MoIV and WIV complexes with S,S; S,O and O,O donor ligands is described. The strategy includes the synthesis of two compounds, [M(mnt)2(dppe)] (M = Mo, 1a; W, 1b; dppe, 1,2-bis diphenylphosphinoethane; mnt, maleonitrile dithiolate), which were then utilized for the synthesis of the complexes [M(mnt)2(o-O,S-C6H4)](X)2 (M = Mo, X = ‘PNP’, 2a; M = W, X = Ph4P, 2b), [M(mnt)2(o-O,O-C6H4)](Ph4P)2 (M = Mo, 3a; M = W, 3b) and [M (mnt)2(bdt)](PNP)2 (M = Mo, 4a; M = W, 4b). A detailed comparative description of the molecular structures, solution stability and redox reactions of these complexes is presented.
Published: 2017
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24. EPIDEMIOLOGY

Author: S. Khatua, R. Brown, M. Pearlman, T. Vats, D. Satge, C. Stiller, S. Rutkowski, A. O. von Bueren, B. Lacour, D. Sommelet, M. Nishi, M. Massimino, M.-L. Garre, F. Moreno, H. Hasle, Z. Jakab, M. Greenberg, N. von der Weid, C. Kuehni, O. Zurriaga, M.-L. Vicente, R. Peris-Bonet, M. Benesch, M. Vekemans, S. Sullivan, C. Rickert, P. G. Fisher, J. Von Behren, D. O. Nelson, P. Reynolds, K. Fukuoka, T. Yanagisawa, T. Suzuki, T. Koga, K. Wakiya, J.-i. Adachi, K. Mishima, T. Fujimaki, M. Matsutani, R. Nishikawa, C. Gidding, J. Schieving, P. Wesseling, M. Ligtenberg, N. Hoogerbrugge, M. Jongmans, S. Crosier, S. L. Nicholson, K. Robson, T. Jacques, S. Wharton, N. Bown, A. Michalski, B. Pizer, S. Clifford, E. Sanden, E. Visse, P. Siesjo, A. Darabi, D. Nousome, P. J. Lupo, M. E. Scheurer, I. Nulman, M. Barrera, C. Maxwell, G. Koren, S. Gorelyshev, K. Matuev, A. Lubnin, M. Laskov, N. Lemeneva, N. Mazerkina, E. Khuhlaeva, K. Muller, F. Bruns, T. Pietsch, R.-D. Kortmann, R. Krishnatry, N. Shirsat, R. Kunder, S. Epari, T. Gupta, P. Kurkure, T. Vora, B. Arora, A. Moiyadi, R. Jalali, E. Swieszkowska, B. Dembowska-Baginska, M. Drogosiewicz, I. Filipek, M. Perek-Polnik, W. Grajkowska, D. Perek, D. Johnston, J. Cyr, D. Strother, L. Lafay-Cousin, C. Fryer, K. Scheinemann, A.-S. Carret, A. Fleming, V. Larouche, E. Bouffet, C. Friedrich, A. K. Gnekow, G. Fleischhack, C. M. Kramm, M. C. Fruehwald, H. L. Muller, G. Calaminus, U. Kordes, A. Faldum, M. Warmuth-Metz, R. D. Kortmann, I. Jung, P. Kaatsch, V. Caretti, M. Bugiani, I. Boor, P. Schellen, W. P. Vandertop, D. P. Noske, G. Kaspers, T. Wurdinger, G. Robinson, M. Chingtagumpala, A. Adesina, J. Dalton, M. Santi, A. Sievert, K. Wright, G. Armstrong, D. Boue, R. Olshefski, S. Scott, A. Huang, R. Cohn, S. Gururangan, D. Bowers, R. Gilbertson, A. Gajjar, D. Ellison, E. Chick, A. Donson, E. Owens, A. A. Smith, J. R. Madden, N. K. Foreman, D. Bakry, M. Aronson, C. Durno, R. Hala, R. Farah, N. Amayiri, Q. Alharbi, A. Shamvil, S. Ben-Shachar, S. Constantini, D. Rina, J. Ellise, S. Keiles, A. Pollet, I. Qaddoumi, S. Gallinger, D. Malkin, C. Hawkins, U. Tabori, M. Trivedi, J. Goodden, P. Chumas, A. Tyagi, R. O'kane, R. O'Kane, D. Crimmins, S. Picton, and M. Elliott
Subjects: CD antigen, Cancer Research, Pathology, medicine.medical_specialty, Cluster of differentiation, CD24, business.industry, Cancer, CD15, medicine.disease, Malignancy, Abstracts, Immune system, Oncology, Parenchyma, Medicine, Neurology (clinical), business
Abstract: BACKGROUND: Malignant pediatric brain tumors constitute a heterogeneic group of central nervous system tumors, and general markers of diagnosis and prognosis are not available. Recently, a panel of CD markers (CD15, CD24, CD29) was used to define increasing neural differentiation of embryonic stem cells. Although these CD markers have been associated with worse prognosis due to presence of tumor propagating cells, alterations in adhesion and migration in various cancer types, no studies of multiple CD markers in pediatric brain tumors have been performed. METHODS: We have collected tumors, including medulloblastomas (MB), ependymomas (EP) and juvenile astrocytomas, from >20 pediatric brain tumor patients. Frozen tumor sections and cultured tumor cells were stained for CD15, CD24 and CD29 and analyzed using fluorescence microscopy or flowcytometry. RESULTS: MB contained a mixture of cells with strong CD15 labeling inside vessels and cells with diffuse CD15 staining in the parenchyma of the tumor tissue. Cells strongly labeled with CD15 were also positive for the leukocyte marker CD45. The previously proposed association between CD15 expression and prognosis in MB could instead of reflecting abundance of tumor propagating cells depend on infiltrating immune cells. In low-grade pediatric tumors and EP, larger areas stained weakly for CD15 while few cells displayed strong staining. CD24 was expressed on the vast majority of cells in pediatric brain tumors, despite grade of malignancy. MB, however, displayed an intense and aberrant staining for CD24. Computerized image analysis of frozen tumor sections showed that proliferation of cells and the expression of CD29 correlated in a sub-group of MB. CONCLUSIONS: Our preliminary data show that CD15, CD24 and CD29 are differentially expressed in high- and low-malignant pediatric brain tumors in vivo. By defining the patterns of CD antigen expression in different pediatric tumors their relationship to biological behavior and thus prognosis can be established. (Less)
Published: 2012

25. CLINICAL TRIALS

Author: S. Stapleton, J. Flanary, F. Hamblin, S. Steinbrueck, L. Rodriguez, G. Tuite, C. Carey, B. Storrs, R. Lavey, J. Fangusaro, R. Jakacki, S. Kaste, S. Goldman, I. Pollack, J. Boyett, L. Kun, S. Gururangan, E. Dombi, S. Steinberg, M. Kieran, N. Ullrich, B. Widemann, R. Lulla, N. Reinholdt, M. Newmark, M. Urban, S. Chi, P. Manley, N. Robison, H.-A. Kroon, T. Stancokova, K. Husakova, L. Deak, A. Onar-Thomas, R. Packer, H. Friedman, T. Y. Poussaint, F. Gudrun, S. Tippelt, M. Zimmermann, S. Rutkowski, M. Warmuth-Metz, T. Pietsch, A. Faldum, U. Bode, I. Slavc, A. Peyrl, M. Chocholous, A. Azizi, T. Czech, K. Dieckmann, C. Haberler, M. Macy, K. Cohen, T. MacDonald, A. Smith, M. Etzl, A. Naranderan, L. Gore, J. DiRenzo, T. Trippett, N. Foreman, I. Dunkel, M. J. Fisher, J. Meyer, T. Roberts, J. B. Belasco, P. C. Phillips, R. Lustig, A. M. Cahill, A. Laureano, H. Huls, S. Somanchi, C. Denman, I. Liadi, S. Khatua, N. Varadarajan, R. Champlin, D. Lee, L. Cooper, L. Silla, V. Gopalakrishnan, G. Legault, M. Hagiwara, M. Ballas, K. Brown, E. Vega, A. Nusbaum, M. Bloom, T. Hochman, J. Goldberg, J. Golfinos, J. T. Roland, J. Allen, M. Karajannis, A. Bergner, M. Giovannini, D. B. Welling, J. Niparko, W. Slattery, J. Blakeley, C. Owens, L. Sung, S. Lowis, J.-C. Gentet, E. Bouffet, J. Henry, A. Bala, S. Freeman, A. King, S. Rutherford, S. Mills, S. Huson, C. McBain, S. Lloyd, G. Evans, M. McCabe, Y. Lee, U. Bartels, U. Tabori, L. Jansen, D. Mabbott, A. Huang, D. Aguilera, C. Mazewski, R. McNall, L. Hayes, Y. Liu, R. Castellino, D. Cole, C. Lester-McCully, K. Warren, F. Campigotto, C. Turner, M. A. Zimmerman, C. Chordas, J. Rubin, M. Isakoff, W. Pan, Z. Khatib, M. Comito, A. Bendel, J. Pietrantonio, L. Kondrat, S. Hubbs, D. Neuberg, C. Wetmore, A. Broniscer, K. Wright, G. Armstrong, J. Baker, A. Pai-Panandiker, Z. Patay, A. Ramachandran, D. Turner, A. Gajjar, and C. Stewart
Subjects: Cancer Research, Abstracts, Oncology, Neurology (clinical)
Published: 2012

26. MEDICAL AND NEURO-ONCOLOGY

Author: G. K. Prithviraj, S. R. Sommers, R. L. Jump, B. Halmos, L. B. Chambless, S. L. Parker, L. Hassam-Malani, M. J. McGirt, R. C. Thompson, K. Hunter, M. C. Chamberlain, E. M. Le, E. L. T. Lee, Z. S. Sadighi, M. L. Pearlman, J. M. Slopis, T. S. Vats, S. Khatua, N. C. DeVito, M. Yu, R. Chen, E. Pan, T. Cloughesy, J. Raizer, J. Drappatz, M. Gerena-Lewis, J. Rogerio, S. Yacoub, A. Desjardin, M. D. Groves, J. DeGroot, M. Loghin, C. A. Conrad, K. Hess, J. Ni, S. Ictech, W. A. Yung, A. B. Porter, A. C. Dueck, N. J. Karlin, J. Olson, J. Silber, A. S. Reiner, K. S. Panageas, F. M. Iwamoto, T. F. Cloughesy, K. D. Aldape, A. L. Rivera, A. F. Eichler, D. N. Louis, N. A. Paleologos, B. J. Fisher, L. S. Ashby, J. G. Cairncross, G. B. Roldan, P. Y. Wen, K. L. Ligon, D. Shiff, H. I. Robins, B. G. Rocque, W. P. Mason, S. A. Weaver, R. M. Green, F. G. Kamar, L. E. Abrey, L. M. DeAngelis, S. C. Jhanwar, M. K. Rosenblum, A. B. Lassman, D. Cachia, L. Alderson, R. Moser, T. Smith, S. Yunus, K. Saito, A. Mukasa, Y. Narita, Y. Tabei, N. Shinoura, S. Shibui, N. Saito, B. Flechl, M. Ackerl, C. Sax, K. Dieckmann, R. Crevenna, G. Widhalm, M. Preusser, C. Marosi, C. Ay, D. Dunkler, I. Pabinger, C. Zielinski, M. Belongia, S. Jogal, K.-H. Schlingensiepen, U. Bogdahn, G. Stockhammer, A. K. Mahapatra, N. K. Venkataramana, V. Oliushine, V. Parfenov, I. Poverennova, P. Hau, P. Jachimczak, H. Heinrichs, A. G. Mammoser, N. A. Shonka, J. F. de Groot, I. Shibahara, Y. Sonoda, T. Kumabe, R. Saito, M. Kanamori, Y. Yamashita, M. Watanabe, C. Ishioka, T. Tominaga, A. Silvani, P. Gaviani, E. Lamperti, A. Botturi, F. DiMeco, G. Broggi, L. Fariselli, C. L. Solero, A. Salmaggi, E. A. Woyshner, F. Shu, Y. S. Oh, S. Iganej, G. Singh, S. L. Vemuri, B. J. Theeler, B. Ellezam, M. R. Gilbert, T. Aoki, H. Kobayashi, S. Takano, R. Nishikawa, M. Nagane, Y. Muragaki, K. Sugiyama, J. Kuratsu, M. Matsutani, L. A. Langford, V. K. Puduvalli, D. Shen, Z.-p. Chen, J.-p. Zhang, D. Bedekar, S. Rand, J. Connelly, M. Malkin, E. Paulson, W. Mueller, K. Schmainda, O. Gallego, M. Benavides, P. P. Segura, C. Balana, M. Gil, A. Berrocal, G. Reynes, J. L. Garcia, P. Murata, S. Bague, M. J. Quintana, V. G. Vasishta, K. Kobayashi, M. Tanaka, K. Tsuchiya, Y. Shiokawa, A. A. Bavle, K. Ayyanar, M. P. Prado, K. R. Hess, V. Liu, J. de Groot, M. E. Loghin, H. Colman, V. A. Levin, W. K. Alfred Yung, J. R. Hackney, C. A. Palmer, J. M. Markert, J. Cure, K. O. Riley, H. Fathallah-Shaykh, L. B. Nabors, M. G. Saria, C. Corle, J. Hu, J. Rudnick, S. Phuphanich, M. M. Mrugala, L. K. Lee, B. D. Fu, D. A. Bota, R. Y. Kim, T. Brown, H. Feely, A. Hu, J. W. Lee, B. Carter, S. Kesari, X.-T. Kong, S. Sparagana, E. Belousova, S. Jozwiak, B. Korf, M. Frost, R. Kuperman, M. Kohrman, O. Witt, J. Wu, R. Flamini, A. Jansen, P. Curtalolo, E. Thiele, V. Whittemore, P. De Vries, J. Ford, G. Shah, H. Cauwel, P. Edrich, T. Sahmoud, D. Franz, M. Khasraw, C. Brown, D. M. Ashley, M. A. Rosenthal, X. Jiang, Y. g. Mou, Z. p. Chen, M. Oh, E. kim, J. Chang, T. A. Juratli, M. Kirsch, G. Schackert, D. Krex, M. Wang, R. Stupp, M. Hegi, K. A. Jaeckle, T. S. Armstrong, J. S. Wefel, M. Won, D. T. Blumenthal, A. Mahajan, C. J. Schultz, S. C. Erridge, P. D. Brown, A. Chakravarti, W. J. Curran, M. P. Mehta, K. F. Hofland, S. Hansen, M. Sorensen, H. Schultz, A. Muhic, S. Engelholm, A. Ask, C. Kristiansen, C. Thomsen, H. S. Poulsen, U. N. Lassen, O. Zalatimo, C. Weston, C. Zoccoli, M. Glantz, S. Rahmanuddin, M. S. Shiroishi, S. Y. Cen, J. Jones, T. Chen, P. Pagnini, J. Go, A. Lerner, J. Gomez, M. Law, Z. Ram, E. T. Wong, P. H. Gutin, M. S. Bobola, M. Alnoor, D. L. Silbergeld, R. C. Rostomily, J. R. Silber, N. Martha, S. Jacqueline, G. Thaddaus, P. Daniel, M. Hans, M. Armin, T. Eugen, S. Gunther, M. Hutterer, H.-M. Tseng, C. M. Zoccoli, A. Patel, K. Rizzo, J. M. Sheehan, A. L. Sumrall, J. J. Vredenburgh, A. Desjardins, D. A. Reardon, H. S. Friiedman, K. B. Peters, L. P. Taylor, M. Stewart, N. A. Blondin, J. M. Baehring, T. Foote, N. Laack, J. Call, M. G. Hamilton, S. Walling, M. Eliasziw, J. Easaw, N. V. Shirsat, R. Kundar, A. Gokhale, A. Goel, A. A. Moiyadi, J. Wang, E. Mutlu, A. Oyan, T. Yan, O. Tsinkalovsky, H. K. Jacobsen, K. M. Talasila, L. Sleire, K. Pettersen, H. Miletic, S. Andersen, S. Mitra, I. Weissman, X. Li, K.-H. Kalland, P. O. Enger, J. Sepulveda, C. Belda, R. Sitt, L. Phishniak, F. Bokstein, M. Philippe, C. Carole, M. d. P. Andre, B. Marylin, C. Olivier, O. L'Houcine, F.-B. Dominique, N.-M. Isabelle, F. Frederic, F. Stephane, D. Henry, M. A. Errico, L. J. Kunschner, R. Soffietti, E. Trevisan, R. Ruda, L. Bertero, C. Bosa, M. G. Fabrini, I. Lolli, R. Jalali, P. K. Julka, A. K. Anand, D. Bhavsar, N. Singhal, R. Naik, S. John, B. S. Mathew, I. Thaipisuttikul, J. Graber, M. Shirinian, A. M. Fontebasso, K. Jacob, N. Gerges, A. Montpetit, A. Nantel, S. Albrecht, N. Jabado, K. Shah, K. Di, M. Linskey, N. Thon, S. Eigenbrod, S. Kreth, J. Lutz, J.-C. Tonn, H. Kretzschmar, A. Peraud, F.-W. Kreth, A. D. Muggeri, J. P. Alderuccio, B. D. Diez, P. Jiang, Y. Chao, M. Gallagher, R. Kim, S. Pastorino, V. Fogal, J. D. Rudnick, C. Bresee, A. Rogatko, S. Sakowsky, M. Franco, S. Lim, A. Lopez, L. Yu, K. Ryback, V. Tsang, M. Lill, A. Steinberg, R. Sheth, S. Grimm, I. Helenowski, A. Rademaker, F. P. Nunes, V. Merker, D. Jennings, P. Caruso, A. Muzikansky, A. Stemmer-Rachamimov, S. Plotkin, A. C. Spalding, T. W. Vitaz, D. A. Sun, S. Parsons, M. R. Welch, A. Omuro, K. Beal, D. Correa, T. Chan, L. DeAngelis, I. Gavrilovic, C. Nolan, A. Hormigo, T. Kaley, I. Mellinghoff, C. Grommes, K. Panageas, A. Reiner, R. Barradas, L. Abrey, P. Gutin, S. Y. Lee, B. Slagle-Webb, M. J. Glantz, J. R. Connor, C. A. Schlimper, H. Schlag, G. Stoffels, F. Weber, D. A. Krueger, M. M. Care, K. Holland, K. Agricola, C. Tudor, A. Byars, D. N. Franz, L. Rice, J. Chandler, R. Levy, K. Muro, L. Nayak, A. D. Norden, T. J. Kaley, A. A. Thomas, C. E. Fadul, L. P. Meyer, E. C. Lallana, M. Gilbert, K. Aldape, J. De Groot, C. Conrad, V. Levin, M. Groves, P. Chris, V. Puduvalli, S. Nagpal, A. Feroze, L. Recht, H. G. Rangarajan, M. W. Kieran, R. M. Scott, S. M. Lew, S. Y. Firat, A. D. Segura, S. A. Jogal, P. U. Kumthekar, S. A. Grimm, M. Avram, J. Patel, V. Kaklamani, K. McCarthy, M. Cianfrocca, W. Gradishar, M. Mulcahy, J. Von Roenn, E. Galanis, S. K. Anderson, J. M. Lafky, T. J. Kaufmann, J. H. Uhm, C. Giannini, S. K. Kumar, D. W. Northfelt, P. J. Flynn, J. C. Buckner, A. I. Omar, D. Schiff, A. Delios, A. Jakubowski, I. Melguizo-Gavilanes, W. Qiao, X. Wang, N. Hashemi-Sadraei, H. Bawa, G. Rahmathulla, M. Patel, P. Elson, G. Stevens, D. Peereboom, M. Vogelbaum, R. Weil, G. Barnett, M. S. Ahluwalia, E. C. Alvord, R. C. Rockne, J. K. Rockhill, R. Rostomily, A. Lai, J. Wardlaw, A. M. Spence, K. R. Swanson, G. Zadeh, H. Alahmadi, J. Wilson, F. Gentili, J. J. Beumer, J. Wright, N. Takebe, R. Gaur, M. Werner-Wasik, A. J. Gupta, A. Campos-Gines, K. Le, C. Arango, M. Richards, M. Landeros, H. Juan, J. H. Chang, J. S. Kim, J. H. Cho, C. O. Seo, A. L. Baldock, R. Rockne, P. Canoll, D. Born, K. Yagle, D. Alexandru, D. Bota, M. E. Linskey, S. Nabeel, S. N. Raval, J. Rosenow, M. Bredel, P. Z. New, S. R. Plotkin, J. G. Supko, W. T. Curry, A. S. Chi, E. R. Gerstner, T. T. Batchelor, N. Hashemi, S. T. Chao, R. J. Weil, J. H. Suh, M. A. Vogelbaum, G. H. Stevens, G. H. Barnett, D. Corwin, C. Holdsworth, R. Stewart, K. Swanson, J. J. Graber, A. R. Anderson, S. Jeyapalan, M. Goldman, J. Boxerman, J. Donahue, H. Elinzano, D. Evans, B. O'Connor, M. Y. Puthawala, A. Oyelese, D. Cielo, M. Blitstein, M. Dargush, A. Santaniello, M. Constantinou, T. DiPetrillo, H. Safran, C. Halpin, F. G. Barker, E. A. Maher, S. Ganji, R. DeBerardinis, K. Hatanpaa, D. Rakheja, X.-L. Yang, T. Mashimo, J. Raisanen, C. Madden, B. Mickey, C. Malloy, R. Bachoo, C. Choi, T. Ranjan, N. Yono, S. J. Han, M. Sun, M. S. Berger, M. Aghi, N. Gupta, and A. T. Parsa
Subjects: Cancer Research, medicine.medical_specialty, Abstracts, Oncology, business.industry, Neuro oncology, medicine, Medical physics, Neurology (clinical), business
Published: 2011

27. Estimation of Self-Injection Length in Heterostructures of YBa2Cu3O7-δ Superconductor and La0.67Ca0.33MnO3 Manganite

Author: S. Khatua, S. Wanchoo, T. Bannerjee, C.M. Thakar, and S.K. Malik
Published: 2006
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28. Development of diclofenac sodium-loaded alginate-PVP K 30 microbeads using central composite design.

Author: A. K., Nayak, S., Khatua, M. S., Hasnain, and K. K., Sen
Subjects: *PHARMACEUTICAL chemistry, *DRUG development, *DICLOFENAC
Abstract: Background and the purpose of the study: Diclofenac sodium is a non-steroidal anti-inflammatory agent with a short biological half-life (1-2 hr) and requires multiple dosing. This research was carried out to develop and optimize diclofenac sodium loaded alginate-PVP K 30 microbeads to eliminate the need for multiple dosing and adverse effects. Methods: Diclofenac sodium loaded alginate-PVP K 30 microbeads were prepared by ionotropic gelation. Particle size, drug release, swelling, FTIR and SEM analyses were performed. Results: Optimized microbeads showed particle size of 0.589 ± 0.054 to 0.620 ± 0.067 mm, and drug entrapment efficiency of 97.88 ± 2.86 to 98.60 ± 3.55 %. The in vitro drug release from microbeads was sustained over 10 hrs and followed controlled-release pattern. FTIR analysis indicated the possibility of intermolecular hydrogen bonding interactions, i.e., -OH...O=C in microbeads. Conclusion: Microbeads for oral controlled delivery of diclofenac sodium were successfully developed by ionotropic gelation. [ABSTRACT FROM AUTHOR]
Published: 2011

29. Immunoglobulin level of low birth weight infants and relation with infective diseases

Author: S P, Khatua, R, Lahiry, S K, Batabyal, S, Khatua, and T, Sabui
Subjects: Pregnancy, Infant, Newborn, Humans, Immunoglobulins, Female, Infant, Low Birth Weight, Pregnancy Complications, Infectious, Infections
Published: 1984

30. Neonatal septicemia

Author: Anjan Das, B. Ghose, S. Khatua, S. P. Khatua, A. Saha, and B. D. Chatterjee
Subjects: Male, medicine.medical_specialty, Klebsiella, India, Microbial Sensitivity Tests, Gastroenterology, Lethargy, Cloxacillin, Ampicillin, Internal medicine, Sepsis, medicine, Humans, Blood culture, Bacteriological Techniques, medicine.diagnostic_test, biology, Respiratory distress, Bacteria, business.industry, Infant, Newborn, biology.organism_classification, Diarrhea, Pediatrics, Perinatology and Child Health, Female, Peptococcus, medicine.symptom, business, medicine.drug
Abstract: A study of 92 consecutive cases of neonatal septicenia showed incidence of clinical and bacteriological positive septicemia of 10·97 and 6·55 per 1,000 live-births respectively. Blood culture was positive in 59·8% cases of which 76·3% showed Gram negative organisms like klebsiella, E. coli, citrobacter, pseudomonas and 23·7% Gram positive organisms predominantly staphylococci and streptococci. Only one anaerobic peptococcus was isolated. 68·5% cases had membrane rupture more than 24 hours before delivery. 70% cases developed septicemia within 5 days. Refusal of feeds, lethargy, diarrhea, hypothermia, abdominal distention and jaundice were the major presenting features. Respiratory distress, apnoeic spells, convulsion, sclerema were bad prognostic features. Gentamycin and cloxacillin were the drugs of choice for combating Gram negative and positive organisms respectively. All cases were resistant to ampicillin. Chloramphenicol showed better result than kanamycin. The overall mortality was 57·6%. Male sex, prematurity, LBW and Gram negative infection were associated with higher incidence and mortality.
Published: 1986

31. Immunological study of bronchial asthma

Author: S P, Khatua, S, Khatua, S K, Batabyal, and P K, Bhowmik
Subjects: Male, Adolescent, Child, Preschool, Humans, India, Infant, Female, Allergens, Immunoglobulin E, Child, Asthma
Published: 1986

32. Kocher Debre Semelaigne syndrome

Author: S P, Khatua, A, Gangwal, and S, Khatua
Subjects: Male, Hypothyroidism, Child, Preschool, Muscles, Humans, Hypertrophy
Published: 1984

33. Anticancer efficacy of thiazole-naphthyl derivatives targeting DNA: Synthesis, crystal structure, density functional theory, molecular docking, and molecular dynamics studies.

Author: Aher A, Bera P, Brandao P, Sharda S, Khatua S, Manna SK, Manhas A, and Bera P
Abstract: Two newly synthesized ligands, 1-((2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazono)methyl)naphthalen-2-ol (HL1) and 1-((2-(4-(naphthalen-1-yl)thiazol-2-yl)hydrazono)methyl)naphthalen-2-ol (HL2) were characterized using spectroscopy and single X-ray crystallography. Both belong to triclinic systems with space groups P21/c (HL1) and P-1 (HL2), exhibiting planar structures. Biological assays revealed significant antitumor activity, with HL2 showing significant antitumor activity against HepG2 cells (IC 50 : 3.2 ± 0.1 μM) compared to HL1 (IC 50 : 7.3 ± 0.3 μM). Mechanistic studies revealed HL2 induces apoptosis, while HL1 triggers necroptosis, and both were non-toxic to peripheral blood mononuclear cells (PBMC). UV-Vis titration showed that HL2 binds more strongly to DNA (K b : 1.08 ± 0.215 × 10 5 M -1 ) than HL1 (K b : 1.02 ± 0.155 × 10 4 M -1 ), attributed to stronger naphthyl chromophore stacking with DNA base pairs. Supporting this, hypochromic effects, circular dichroism spectra, and increased DNA viscosity suggest HL2 is a moderate intercalator, while HL1 functions as a groover binder. Docking studies revealed that in HL2, an additional naphthyl group enhances DNA binding affinity, explaining its superior efficacy. Molecular dynamics simulations further confirmed the stable binding of both ligands to DNA in the biological environment. These experimental and theoretical findings highlight the superior binding affinity of HL2 and its potential as a promising candidate for cancer therapy., Competing Interests: Declaration of competing interest The authors declare no conflict of interest regarding the publication of this manuscript., (Copyright © 2025 Elsevier B.V. All rights reserved.)
Published: 2025
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34. p53 mediated regulation of LINE1 retrotransposon derived R-loops.

Author: Paul P, Kumar A, Parida AS, De AK, Bhadke G, Khatua S, and Tiwari B
Abstract: Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons, which comprise 17% of the human genome, typically remain inactive in healthy somatic cells but are reactivated in several cancers. We previously demonstrated that p53 silences L1 transposons in human somatic cells, potentially acting as a tumor-suppressive mechanism. However, the precise molecular mechanisms underlying p53-mediated repression of L1 and its life cycle intermediates remain unclear. In this study, we used DRIP-sequencing experiments to investigate RNA-DNA hybrids, which are key intermediates formed during L1 retrotransposition. Our findings reveal that L1 mRNA-genomic DNA (cis L1 R-loops) and L1 mRNA-complementary DNA (trans L1 R-loops) hybrids, are de-repressed in p53 -/- cells. This increase is synergistic with L1 activation by HDAC inhibitors (HDACi). However, treatment with a reverse transcriptase inhibitor reduces this accumulation, indicating that retrotransposition activity plays a significant role in R-loop accumulation. Interestingly, in p53 wild-type cells, hyperactivated L1 transposons are re-silenced upon HDACi withdrawal. L1 resilecing in wt cells coincided with the recruitment of repressive marks, specifically H3K9me3 and H3K27me3, simultaneously preventing the addition of activating marks like H3K4me3, and H3K9ac at the L1 5'UTR. Mechanistically, we demonstrate that p53 cooperates with histone methyltransferases SETDB1 and G9A to deposit H3K9me3 marks at the L1 promoter, thereby silencing transposons. This study is the first to reveal novel roles of p53 in preventing the formation of L1-derived RNA-DNA hybrids (R-loops) and re-silencing of hyperactivated L1 elements by co-operating with histone methyltransferases, underscoring its critical role in maintaining genomic stability., Competing Interests: Conflict of Interests The authors declare no competing interests., (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2025
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35. In Vitro and In-Silico Assessment of Gaussian Curvature-driven Internalization Kinetics of Nanoparticles.

Author: Pandey PK, Singh PP, Khatua S, Ranganathan R, and Mishra A
Abstract: Nanoparticles have been of significant interest in various biomedical domains such as drug delivery, gene delivery, cytotoxicity analysis, and imaging. Despite the synthesis of a variety of nanoparticles, their cellular uptake efficiency remains a substantial obstacle, with only a small fraction of delivered nanoparticles (NPs) have been reported to traverse the cell membrane within 24 h. Consequently, higher doses are often necessitated, leading to increased toxicity concerns. In this investigation, we illustrate that nanoparticles having negative Gaussian curvature demonstrate rapid and efficient internalization into cells by lowering the energy barrier for membrane bending. Specifically, three types of gold nanoparticles; gold nanorods (GNR), gold nanodogbones at pH 4 (GDB4), and gold nanodogbones at pH 6 (GDB6) were synthesized, with Gaussian curvatures of 0, -166.91, and -376.62, respectively. Cellular uptake studies conducted via ICP-OES analysis reveal that GDB6 is taken up 140% more in A549 cells and 77% more in NIH3T3 cells compared to GNR. Confocal microscopy-based uptake studies further confirm the higher uptake of GDB6 compared to GNR. Additionally, molecular simulations indicate that GDB nanoparticles exhibit a significantly larger free energy change during translocation compared to GNR, emphasizing the impact of nanoparticle shape on uptake and translocation through the membrane and validating the efficacy of negative Gaussian curvature in enhancing cellular uptake, consistent with experimental observations. Overall, our findings emphasize the importance of nanoparticle curvature modulation in maximizing cellular uptake efficiency for improved biomedical applications, providing valuable insights into the design of nanomaterials for drug delivery purposes.
Published: 2024
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36. The emerging field of viroimmunotherapy for pediatric brain tumors.

Author: Garcia-Moure M, Laspidea V, Gupta S, Gillard AG, Khatua S, Parthasarathy A, He J, Lang FF, Fueyo J, Alonso MM, and Gomez-Manzano C
Subjects: Humans, Child, Animals, Oncolytic Viruses, Brain Neoplasms therapy, Oncolytic Virotherapy methods
Abstract: Pediatric brain tumors are the most common solid tumors in children. Even to date, with the advances in multimodality therapeutic management, survival outcomes remain dismal in some types of tumors, such as pediatric-type diffuse high-grade gliomas or central nervous system embryonal tumors. Failure to understand the complex molecular heterogeneity and the elusive tumor and microenvironment interplay continues to undermine therapeutic efficacy. Developing a strategy that would improve survival for these fatal tumors remains unmet in pediatric neuro-oncology. Oncolytic viruses (OVs) are emerging as a feasible, safe, and promising therapy for brain tumors. The new paradigm in virotherapy implies that the direct cytopathic effect is followed, under certain circumstances, by an antitumor immune response responsible for the partial or complete debulking of the tumor mass. OVs alone or combined with other therapeutic modalities have been primarily used in adult neuro-oncology. A surge in encouraging preclinical studies in pediatric brain tumor models recently led to the clinical translation of OVs with encouraging results in these tumors. In this review, we summarize the different virotherapy tested in preclinical and clinical studies in pediatric brain tumors, and we discuss the limitations and future avenues necessary to improve the response of these tumors to this type of therapy., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Published: 2024
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37. Unravelling structural insights into ligand-induced photoluminescence mechanisms of sulfur dots.

Author: Sahoo SR, Mukhopadhyay A, Mahata S, Kumari K, Praneeth NVS, Baksi A, Khatua S, Saha S, Rakshit S, and Goswami N
Abstract: Sulfur dots (S-QDs) hold promise as a new category of metal-free, luminescent nanomaterials, yet their practical application faces challenges primarily due to a limited understanding of their structure and its impact on their optical properties. Herein, by employing a spectrum of aliphatic and aromatic ligands, we identify the surface structure and composition of S-QDs while delineating the pivotal role of ligands in inducing photoluminescence. Thiol-functionalized ligands, such as 4-mercapto benzoic acid and glutathione, notably promote the formation of both green and blue luminescent S-QDs, boosting a high quantum yield of up to 56%. Further investigation on the synthesis of S-QDs with 4-mercapto benzoic acid unveils the dual role of H 2 O 2 : etching sulfur powder and oxidizing the -SH group to -SO 2 H. These oxidized ligands passivate the S-QD surface through hydrogen bonding. Electrospray ionization mass spectrometry analysis unveils the presence of distinct sulfur species such as [S 4 (C 6 H 5 SO 2 H) 4 (H 2 O) 2 H] + and [S 6 (C 6 H 5 SO 2 H) 6 (H 2 O) 3 H] + , while XPS analysis confirms the existence of zerovalent sulfur and oxidized sulfur species including SO 3 2- . Further detailed spectroscopic examination demonstrates that S-QDs predominantly exist as aggregated entities, with the emission wavelength correlating with the degree of aggregation. The absence of photoluminescence in aggregations devoid of ligands underscores the critical role of ligands in the photoluminescence genesis of S-QDs.4 2- . Further detailed spectroscopic examination demonstrates that S-QDs predominantly exist as aggregated entities, with the emission wavelength correlating with the degree of aggregation. The absence of photoluminescence in aggregations devoid of ligands underscores the critical role of ligands in the photoluminescence genesis of S-QDs.
Published: 2024
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38. Exploring the electrochemical performance of layered Bi 2 Se 3 hexagonal platelets as the anode material for lithium-ion batteries.

Author: Abzal SM, Khatua S, Kalyan K, Janga S, Patel R, Patro LN, and Dash JK
Abstract: The escalating need for lithium-ion batteries (LIBs), driven by their expanding range of applications in our daily lives, has led to a surge in interest in metal selenides as potential anode materials. Among them, Bi 2 Se 3 stands out as a promising anode material for LIBs due to its unique layered structure. Herein, we explored hexagonally structured layered Bi 2 Se 3 platelets synthesized using the solvothermal method. The electrochemical performance of these platelets in LIBs was thoroughly examined, revealing an impressive initial discharge specific capacity of 556 mA h g -1 at a current density of 100 mA g -1 and a coulombic efficiency of 66.5%. Improved cycling stability, rate performance, and discharge voltage profile at various current densities were observed. The plateaus observed during the charge/discharge profile were clearly illustrated by the CV results. The reaction kinetics indicated that both ion diffusion and pseudo-capacitance behavior are crucial for the observed high electrochemical performance. Moreover, the hexagonal Bi 2 Se 3 platelets exhibited a high ion-diffusion coefficient of 1.8 × 10 -13 cm 2 s -1 and a charge transfer impedance of 23 Ω post-cycling. Furthermore, the crystal structure, lattice vibrational bonding, and surface morphology of Bi 2 Se 3 were explored using X-ray diffraction, Raman spectroscopy, scanning electron microscopy, and transmission electron microscopy. FTIR spectroscopy was utilized for identifying the functional groups, while X-ray photoelectron spectroscopy (XPS) was used to identify the elemental composition and oxidation states of Bi 2 Se 3 .
Published: 2024
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39. Ruthenium complex based nanocomposite film with enhanced and selective electrochemical sensing of bifenthrin pesticide.

Author: Bhandari S, Sen B, Khatua S, Singh LR, Parihar VS, and Mahato M
Abstract: Bifenthrin (BF), a widely used pyrethroid pesticide in farming, lacks highly sensitive and selective sensors despite its extensive application. Ruthenium complexes are very effective for selective sensing applications but suffer from structural instability at elevated conditions, electrochemical activity, and the use of costly electrolytes. This work improves their electrochemical activity and mechanical strength by incorporating silver nanowires and replacing the costly electrolyte with abundant KCl + PBS, resulting in enhanced signal performance. Herein, a ruthenium complex containing composite film was immobilized on a platinum (Pt) electrode using Langmuir Blodgett technique. The fabricated sensor has been characterized by differential pulse voltammetry (DPV) based electrochemical technique. The BF pesticide sensing parameters, including the limit of detection (LOD), linear range (LR), and sensitivity, were evaluated using SWV, DPV, and CV techniques. Among these, the DPV technique demonstrated the best performance, achieving a sensitivity of 0.648 μA cm -2 μM -1 , a LR of 1-10 μM, and a LOD of 1 μM. The relative standard deviation (RSD) values using DPV are found to be 6.3% (repeatability study), 3% (reproducibility study), 8% (metal ion interference), 5% (organic species interference), and 2% (real sample study), which are much lesser than the World Health Organization (WHO) recommendation of RSD value on the pesticide ( i.e. 20%). The BF sensor demonstrated a selectivity of 2× difference of peak height response compared to similar pesticides. The reported pesticide sensor will open new options for sensor research using metal complex-based LB film nanocomposite., Competing Interests: The authors declare that there is no competing interest., (This journal is © The Royal Society of Chemistry.)
Published: 2024
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40. Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions.

Author: Nandi S, Sikder R, Nag A, Khatua S, Sen S, Chakraborty N, Naskar A, Zhakipbekov K, Acharya K, Habtemariam S, Arslan Ateşşahin D, Goloshvili T, Ahmed Aldahish A, Sharifi-Rad J, and Calina D
Abstract: Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements in diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on α-solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti-allergic, antipyretic, anti-inflammatory, anti-diabetic, and antibiotic properties. Recently, α-solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on α-solanine's anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses α-solanine's potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large-scale α-solanine extraction. The study concludes that α-solanine holds promise as a standalone or adjunctive cancer treatment. However, further research is necessary to optimize this lead compound and mitigate its toxicity through various strategies., Competing Interests: None., (© 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)
Published: 2024
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41. TlSn 2 F 5 , a SnF 2 -based solid electrolyte with high ionic conductivity and electrochemical stability for all-solid-state fluoride ion batteries.

Author: Ramakrushna Achary K, Khatua S, Kamala Bharathi K, and Patro LN
Abstract: Fluoride-ion batteries (FIBs) offer better theoretical energy densities and temperature stability, making them suitable alternatives to expensive Li-ion batteries. Major studies on FIBs operating at room temperature focus mainly on MSnF 4 (M: Ba and Pb) solid electrolytes due to their favourable ionic conductivity values. PbSnF 4 is the best fluoride ionic conductor known to date. However, it exhibits poor electrochemical stability. The present work demonstrates the development of TlSn 2 F 5 through a single-step mechanical milling method. TlSn 2 F 5 exhibits a better ionic conductivity value compared to the earlier reported various solid electrolytes, such as BaSnF 4 , KSn 2 F 5 , and La 0.9 Ba 0.1 F 2.9 , commonly considered for FIBs. Ionic transport number measurement using the dc polarization method indicates that TlSn 2 F 5 is an ionic conductor. Furthermore, 19 F NMR spectra measured at various temperatures demonstrate that the rise in conductivity with temperature is attributed to the rapid transport of fluoride ions. The present study indicates that TlSn 2 F 5 can be utilized as a potential solid electrolyte for fabricating FIBs.
Published: 2024
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42. Phenolate-thiazole based reversible "turn-on" chemosensor for the selective detection of carbonate anion: X-ray crystallography, DFT/TDFT, and cell study.

Author: Pramanik C, Jana A, Brandao P, Aher A, Bera P, Khatua S, Majumdar S, Mandal B, Kumar Manna S, and Bera P
Subjects: Crystallography, X-Ray, Humans, Models, Molecular, Spectrometry, Fluorescence, Hydrogen-Ion Concentration, Limit of Detection, Phenols chemistry, Phenols analysis, Fluorescent Dyes chemistry, Fluorescent Dyes chemical synthesis, Thiazoles chemistry, Anions analysis, Density Functional Theory, Carbonates chemistry
Abstract: A new phenolate-thiazole derivative (L) has been synthesized and structurally characterized.The chemo-sensing activity of L is detected by the naked eye for the aqueous carbonate anion in the pH range of 4 to 8. The selective 'turn-on' fluorescence occurs through the formation of a stable intermediate L∙CO 3 2- (1) following the PET mechanism. The limit of detection (LOD) is found 0.18 µM based on the absorbance-based assay.The quinonoid form of bromophenol unit binds strongly with CO 3 2- through thiazole nitrogen and hydrazinic nitrogen. Further, the selective holding of CO 3 2- anion over other planar tetranuclear anions (e.g., SO 3 2- , NO 3 - ) happens with several intra and intermolecular hydrogen bonds as envisaged by the DFT/TDFT study. The formation mechanism of L∙CO 3 2- is proposed based on experimental and theoretical studies. The biological experiments (MTT and cell imaging)reveal the non-cytotoxicity nature of L and the biocompatible uptake of L mostly in the cytoplasm at physiological pH., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
Published: 2024
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43. H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions.

Author: Nonnenbroich LF, Bouchal SM, Millesi E, Rechberger JS, Khatua S, and Daniels DJ
Subjects: Humans, Epigenesis, Genetic, Molecular Targeted Therapy, Mutation genetics, Animals, Glioma genetics, Glioma pathology, Glioma metabolism, Histones metabolism, Brain Stem Neoplasms genetics, Brain Stem Neoplasms pathology, Brain Stem Neoplasms metabolism, Brain Stem Neoplasms therapy
Abstract: Pediatric high-grade gliomas are a devastating subset of brain tumors, characterized by their aggressive pathophysiology and limited treatment options. Among them, H3 K27-altered diffuse midline gliomas (DMG) of the brainstem stand out due to their distinct molecular features and dismal prognosis. Recent advances in molecular profiling techniques have unveiled the critical role of H3 K27 alterations, particularly a lysine-to-methionine mutation on position 27 (K27M) of the histone H3 tail, in the pathogenesis of DMG. These mutations result in epigenetic dysregulation, which leads to altered chromatin structure and gene expression patterns in DMG tumor cells, ultimately contributing to the aggressive phenotype of DMG. The exploration of targeted therapeutic avenues for DMG has gained momentum in recent years. Therapies, including epigenetic modifiers, kinase inhibitors, and immunotherapies, are under active investigation; these approaches aim to disrupt aberrant signaling cascades and overcome the various mechanisms of therapeutic resistance in DMG. Challenges, including blood-brain barrier penetration and DMG tumor heterogeneity, require innovative approaches to improve drug delivery and personalized treatment strategies. This review aims to provide a comprehensive overview of the evolving understanding of DMG, focusing on the intricate molecular mechanisms driving tumorigenesis/tumor progression and the current landscape of emerging targeted interventions.
Published: 2024
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44. Myco-remediation of plastic pollution: current knowledge and future prospects.

Author: Khatua S, Simal-Gandara J, and Acharya K
Subjects: Polymers, Polyethylene metabolism, Biodegradation, Environmental, Alternaria metabolism, Plastics metabolism, Polyurethanes
Abstract: To date, enumerable fungi have been reported to participate in the biodegradation of several notorious plastic materials following their isolation from soil of plastic-dumping sites, marine water, waste of mulch films, landfills, plant parts and gut of wax moth. The general mechanism begins with formation of hydrophobin and biofilm proceding to secretion of specific plastic degarding enzymes (peroxidase, hydrolase, protease and urease), penetration of three dimensional substrates and mineralization of plastic polymers into harmless products. As a result, several synthetic polymers including polyethylene, polystyrene, polypropylene, polyvinyl chloride, polyurethane and/or bio-degradable plastics have been validated to deteriorate within months through the action of a wide variety of fungal strains predominantly Ascomycota (Alternaria, Aspergillus, Cladosporium, Fusarium, Penicillium spp.). Understanding the potential and mode of operation of these organisms is thus of prime importance inspiring us to furnish an up to date view on all the presently known fungal strains claimed to mitigate the plastic waste problem. Future research henceforth needs to be directed towards metagenomic approach to distinguish polymer degrading microbial diversity followed by bio-augmentation to build fascinating future of waste disposal., (© 2023. The Author(s).)
Published: 2024
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45. Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications.

Author: Khatua S, Nandi S, Nag A, Sen S, Chakraborty N, Naskar A, Gürer ES, Calina D, Acharya K, and Sharifi-Rad J
Subjects: Humans, Neoplasms drug therapy, Animals, Hematologic Neoplasms drug therapy, Homoharringtonine therapeutic use, Homoharringtonine pharmacology
Abstract: HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was conducted across various academic databases, including ScienceDirect, Web of Science, Scopus, American Chemical Society, Google Scholar, PubMed/MedLine, and Wiley. The review highlights HHT's diverse mechanisms of action, ranging from its role in leukemia treatment to its emerging applications in managing other cancers and various biomedical conditions. It underscores HHT's influence on cellular processes, its efficacy in clinical settings, and its potential to alter pathological pathways. HHT demonstrates significant promise in treating various hematological malignancies and cancers, offering a multifaceted approach to disease management. Its ability to impact various physiological pathways opens new avenues for therapeutic applications. This review provides a consolidated foundation for future research and clinical applications of HHT in diverse medical fields., (© 2024. The Author(s).)
Published: 2024
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46. Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3 K27M-mutant glioma.

Author: Odia Y, Koschmann C, Vitanza NA, de Blank P, Aguilera D, Allen J, Daghistani D, Hall M, Khatib Z, Kline C, MacDonald T, Mueller S, Faison SL, Allen JE, Naderer OJ, Ramage SC, Tarapore RS, McGovern SL, Khatua S, Zaky W, and Gardner SL
Subjects: Humans, Male, Female, Child, Adolescent, Child, Preschool, Histones, Antineoplastic Agents pharmacokinetics, Antineoplastic Agents administration & dosage, Antineoplastic Agents adverse effects, Pyrimidines pharmacokinetics, Pyrimidines administration & dosage, Pyrimidines adverse effects, Drug Administration Schedule, Maximum Tolerated Dose, Dose-Response Relationship, Drug, Prognosis, Follow-Up Studies, Glioma drug therapy, Glioma genetics, Glioma pathology, Mutation, Brain Neoplasms drug therapy, Brain Neoplasms genetics
Abstract: Background: This study evaluated the safety and pharmacokinetics (PK) of oral ONC201 administered twice-weekly on consecutive days (D1D2) in pediatric patients with newly diagnosed DIPG and/or recurrent/refractory H3 K27M glioma., Methods: This phase 1 dose-escalation and expansion study included pediatric patients with H3 K27M-mutant glioma and/or DIPG following ≥1 line of therapy (NCT03416530). ONC201 was administered D1D2 at 3 dose levels (DLs; -1, 1, and 2). The actual administered dose within DLs was dependent on weight. Safety was assessed in all DLs; PK analysis was conducted in DL2. Patients receiving once-weekly ONC201 (D1) served as a PK comparator., Results: Twelve patients received D1D2 ONC201 (DL1, n = 3; DL1, n = 3; DL2, n = 6); no dose-limiting toxicities or grade ≥3 treatment-related adverse events occurred. PK analyses at DL2 (D1-250 mg, n = 3; D1-625 mg, n = 3; D1D2-250 mg, n = 2; D1D2-625 mg, n = 2) demonstrated variability in Cmax, AUC0-24, and AUC0-48, with comparable exposures across weight groups. No accumulation occurred with D1D2 dosing; the majority of ONC201 cleared before administration of the second dose. Cmax was variable between groups but did not appear to increase with D1D2 dosing. AUC0-48 was greater with D1D2 than once-weekly., Conclusions: ONC201 given D1D2 was well tolerated at all DLs and associated with greater AUC0-48., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.)
Published: 2024
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47. Anticancer activity and other biomedical properties of β-sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches.

Author: Nandi S, Nag A, Khatua S, Sen S, Chakraborty N, Naskar A, Acharya K, Calina D, and Sharifi-Rad J
Subjects: Humans, Male, Animals, Plant Extracts pharmacology, Sitosterols pharmacology, Sitosterols therapeutic use, Phytochemicals pharmacology, Phytochemicals therapeutic use, Ethnopharmacology, Prostatic Neoplasms, Leukemia, Phytosterols
Abstract: Sterols, including β-sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of β-sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. β-sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of β-sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of β-sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of β-sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of β-sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of β-sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. β-sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of β-sitosterol have also shown anti-cancer effects. However, research in the field of drug delivery and the detailed mode of action of β-sitosterol-mediated anticancer activities remains limited. β-sitosterol, as a non-toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, β-sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of β-sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on β-sitosterol as a potent superfood in combating cancer., (© 2023 John Wiley & Sons Ltd.)
Published: 2024
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48. Elucidation of the structural dynamics of mutations in PHB2 protein associated with growth suppression and cancer progression.

Author: Khatua S, Roy A, Sen P, and Ray S
Abstract: Prohibitin is a multifunctional protein that plays an important role in numerous cellular processes. Membrane-associated mitochondrial prohibitin complex is made up of two subunits, PHB1 and PHB2 which are ubiquitously expressed and analogous to each other. High levels of prohibitin expression have consequently been found in esophageal cancer, endometrial adenocarcinoma, gastric cancer, hepatocellular carcinoma, breast cancer and bladder cancer. The aim of this study is to analyse two-point mutation PHB2_MT1(I → A) and PHB2_MT2(I → P), their effect on PHB2 protein and its effect on formation of mitochondrial complex. It is a residual level study, based on current experimental validation. To establish the effects of the two-point mutations, computational approaches such as molecular modelling, molecular docking, normal mode simulation, molecular dynamics simulations and MM/GBSA were used. An analysis of the energy dynamics of both unbound and complex proteins was conducted to elucidate how mutations impact the energy distribution of PHB2. Our study confirmed that the two mutations decreased the overall stability of PHB2. This was evidenced by heightened atomic fluctuations within the mutated region, accompanied by elevated deviations observed in RMSD and R g values. Furthermore, these mutations were correlated with a decline in the organization of secondary structural elements. The mutations in PHB2_MT1 and PHB2_MT2 resulted in formation a less stable prohibitin complex. Thus, PHB1 and PHB2 may act as molecular target or novel biomarkers for therapeutic intervention in numerous forms of malignancies., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
Published: 2024
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49. Aptamers in neuro-oncology: An emerging therapeutic modality.

Author: Doherty C, Wilbanks B, Khatua S, and Maher LJ 3rd
Subjects: Humans, Biomarkers, Aptamers, Nucleotide therapeutic use, Brain Neoplasms drug therapy
Abstract: Despite recent advances in the understanding of brain tumor pathophysiology, challenges associated with tumor location and characteristics have prevented significant improvement in neuro-oncology therapies. Aptamers are short, single-stranded DNA or RNA oligonucleotides that fold into sequence-specific, 3-dimensional shapes that, like protein antibodies, interact with targeted ligands with high affinity and specificity. Aptamer technology has recently been applied to neuro-oncology as a potential approach to innovative therapy. Preclinical research has demonstrated the ability of aptamers to overcome some obstacles that have traditionally rendered neuro-oncology therapies ineffective. Potential aptamer advantages include their small size, ability in some cases to penetrate the blood-brain barrier, inherent lack of immunogenicity, and applicability for discovering novel biomarkers. Herein, we review recent reports of aptamer applications in neuro-oncology including aptamers found by cell- and in vivo- Systematic Evolution of Ligands by Exponential Enrichment approaches, aptamer-targeted therapeutic delivery modalities, and aptamers in diagnostics and imaging. We further identify crucial future directions for the field that will be important to advance aptamer-based drugs or tools to clinical application in neuro-oncology., (© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.)
Published: 2024
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50. Cold Alkali-Extractable Antioxidative Polysaccharide from Russula pseudocyanoxantha (Agaricomycetes), a Novel Mushroom, Stimulates Immune Responses in RAW264.7 Cells by Regulating the TLR/NF-κB Pathway.

Author: Khatua S and Acharya K
Subjects: Animals, Mice, Antioxidants pharmacology, Antioxidants chemistry, NF-kappa B metabolism, Alkalies, Spectroscopy, Fourier Transform Infrared, RAW 264.7 Cells, Polysaccharides pharmacology, Polysaccharides chemistry, Immunity, Biopolymers, Agaricales chemistry, Basidiomycota metabolism
Abstract: In our previous study, we have established Russula pseudocyanoxantha as a unique species, playing a crucial role in indigenous diets through ages. The research also brought attention to bioactive potential of polysaccharide fraction extracted from the unexplored food using hot water. However, residue of the conventional process still contains therapeutic biopolymers that could further be utilized for pharmacological purposes instead of being discarded. Therefore, the current study aims to valorize the solid remnants, contributing to a deeper understanding of the novel taxon. Subsequently, the leftover was treated with cold alkali, leading to the preparation of a high-yield fraction (RP-CAP). Chemical characterization through FT-IR, GC-MS, HPTLC, and spectroscopy demonstrated presence of several monomers in the carbohydrate backbone, predominantly composed of β-glucan. Furthermore, GPC chromatogram indicated presence of a homogeneous polymer with molecular weight of ~ 129.28 kDa. Subsequently, potent antioxidant activity was noted in terms of radical scavenging (O2·-, OH·, DPPH· and ABTS·+), chelating ability, reducing power and total antioxidant activity where EC50 values ranged from 472-3600 μg/mL. Strong immune-boosting effect was also evident, as the biopolymers stimulated murine macrophage cell proliferation, phagocytic activity, pseudopod formation, and NO as well as ROS synthesis particularly at the concentration of 100 μg/mL. In-depth analysis through RT-PCR revealed that the fraction stimulated synthesis of several inflammatory mediators, elucidating the mode of action through TLR/ NF-κB pathway. Therefore, the findings collectively suggest that RP-CAP possesses great potential to serve as a healthimproving component in functional food and pharmaceutical sectors.
Published: 2024
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