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Superconducting (SC) tokamak JT-60SA plays an essential role in fusion research and development by supporting and complementing the ITER project, providing directions to the DEMO design activity and fostering next generation scientists and engineers. Since the short circuit incident at the terminal joints of equilibrium field coil #1 during the integrated commissioning (IC) in March 2021, both EU and JA implementing agencies (IAs) have examined how to ensure safe operation of JT-60SA by mitigating the risk of possible discharge occurrence inside the cryostat. Based on the experience of the global Paschen tests, the IAs have established a strategy of risk mitigation measures, which is a combination of (i) reinforcement of insulation, (ii) avoiding unnecessary voltage application to the coil systems and (iii) immediate de-energization of the coils when deteriorated vacuum conditions are detected. Thanks to the considerable efforts of the Integrated Project Team members, the IC restarted in May 2023. After confirmation of the SC state of the coil systems (TF, EF and CS), the coil energization test and the plasma operation phase 1 (OP-1) started. The first plasma was successfully achieved on 23 October 2023 with a limited value of voltage and current applied to the coils. The plasma configuration control was also confirmed with low plasma current and low auxiliary heating power conditions. Based on the IO–F4E–QST collaboration, activities of JT-60SA have been shared with the IO and provided an important lesson for ITER assembly and commissioning, and will provide an outstanding contribution to fusion research at large. After OP-1, maintenance & enhancement phase 1 (M/E-1) starts from January 2024, in which in-vessel components are installed, and heating and diagnostic systems are extensively upgraded to allow a high power heating experiment planned in OP-2. In order to make the best use of JT-60SA, a newly organized JT-60SA experiment team will refine the research plan for the future high heating power operation phase.

The roadmap for the commissioning and first operations of superconductive tokamaks envisages the possibility of running discharges with fairly elongated plasmas before the complete installation of the in-vessel components, including vertical stabilization coils, or any other specific sets of coils to be used for the magnetic control of fast transients. In the absence of dedicated actuators, the magnetic control system shall perform the essential fast control actions by using the out-vessel superconductive coils, if needed. These are typically less efficient in reacting to fast transients, due to the shielding effect of the vessel and imply a coupling with other control tasks relying on the same actuators, such as plasma current, position, and shape control. Hence, effective actuator-sharing strategies must be put in place. This paper presents an architecture and a possible control strategy that is able to cope with vertically unstable elongated plasmas subject to fast varying disturbances, in the absence of dedicated in-vessel coils. The architecture exploits a model-based actuator-sharing approach to effectively accomplish the main magnetic control objectives while minimizing the cross-couplings among the various tasks. The effectiveness of the approach is demonstrated by means of nonlinear simulations of realistic JT-60SA scenarios. In particular, an isoflux plasma shape controller is integrated with plasma current control and vertical stabilization. The proposed control approach proves to control vertical displacement events and plasma deformations due to fast variations of poloidal beta with satisfactory performance.

The world’s largest superconducting tokamak, JT-60SA, has successfully achieved its first plasma operation under the constraint of a low toroidal inductive electric field of 0.15 V m ^−1 . A plasma start-up scenario, leveraging the effective confinement of electrons accelerated by the electron cyclotron wave, proved to be instrumental in reaching this milestone under the challenging conditions. The demonstration of plasma start-up using second harmonic electron cyclotron heating, with an applied toroidal electric field of 0.15 V m ^−1 , strongly validates the feasibility of achieving first plasma operation in ITER.

Precise control of plasma shape parameters, such as elongation and triangularity is duly needed to achieve high-performance tokamak plasmas, for which we propose adaptive search schemes of (1) optimum regularization parameter for the Tikhonov regularization, and (2) control points to specify the key shape parameters such as elongation and triangularity. Many control points that exceed the number of actuator coils become an ill-conditioned problem, which is successfully resolved by Tikhonov regularization with adaptively optimized free parameters. Furthermore, we develop dynamically changed control points by using the Cauchy Condition Surface scheme, where elongation and triangularity become direct control values. By virtue of both the adaptive Tikhonov regularization scheme and the dynamic control point, we achieved accurate shape control with elongation up to 1.93 and triangularity up to 0.65 in JT-60SA, where the allowable speed for the change of the elongation is 0.1 s ^−1 . We also verified the resilience of our developed our logics to the noises. The sequence of the result will contribute to enhance equilibrium controllability in upcoming JT-60SA experiments and provide the robust shape parameter control scheme for ITER and DEMO.

Characteristics of the early current quench (CQ) time in mitigated disruptions are studied for a full-current (5.5 MA) scenario in the JT-60SA superconducting tokamak. Self-consistent evolution of the plasma temperature and current density profiles during the early CQ phase before the plasma moves vertically is simulated using the axisymmetric disruption code INDEX for given impurity source profiles. It is shown that the hollow (flat) impurity density profiles peaks (flattens) the current density, and it causes a temporal change in the internal inductance in this phase. However the resultant CQ time is found to be insensitive to the impurity source profile for the same assimilated quantity. The simulation results are interpreted by the L/R model including the temporal change in the internal inductance as well as the effect of a gap between the plasma and the conducting vessel structures and stabilizing plates. This results will improve the accuracy to estimate the amount of impurity assimilated into plasma from the observed CQ rate in the massive gas injection (MGI) experiment planned in JT-60SA. The accessible range in which the CQ time can be scanned as well as the electron densities to suppress runaway electrons is also shown for different injected amounts of neon, argon, and their deuterium mixture under the limitation of the MGI gas amount. Mitigated disruptions in JT-60SA typically lead to the CQ time shorter than the vessel wall time, which is expected to produce relevant contributions to disruption mitigation in ITER and future reactors.

The magnetic flux density change ΔB caused by the inverse magnetostrictive effect is key for achieving high-performance vibration power generation. As the magnetization curve of the polycrystalline Fe–47.6 at. % Co–2.3 at. % V (Fe–Co–V) alloy became easier to magnetize by applying tensile stresses, the value of ΔB estimated from the magnetization curves depended significantly on magnetic fields. Hence, the vibration power generation of a U-shaped unimorph device using a polycrystalline Fe–Co–V alloy core was demonstrated under various bias magnetic fields. As a result of bias magnetic field adjustment, the open-circuit voltage induced by the vibration of the device improved to ∼7.0 V. Such superior performance is attributable to a large ΔB of 1.1 T in the Fe–Co–V alloy core. Therefore, adjustment of bias magnetic fields is essential for obtaining large ΔB in Fe–Co–V alloys, which are promising inverse magnetostrictive materials for high-performance vibration power generation.

The plasma startup with ITER-relevant sub-mPa neutral pressures in the JT-60SA superconducting tokamak is studied using a zero-dimensional (0D) power balance model for the plasma burn-through phase. In the ohmic startup scenario assumed here, the lower limit of the operational neutral pressure is determined by the condition for the Townsend avalanche at a high $E/p$ limit, whereas the upper limit depends on the available ohmic heating power for the burn-through with the base power supply (PS) of the superconducting coils, corresponding to 0.2–0.3 V m ^−1 . The operational conditions that lead to RE generation are evaluated to mitigate the risk of RE discharges. The simulation shows that startup REs are generated during the temperature rise immediately after the burn-through under relatively low-density conditions, and then the RE current value is gradually increased in balance with the RE loss processes on the timescale of I _p ramp-up. Therefore, it is expected that REs can be avoided or mitigated if the electron density during the early build-up phase is tuned by a combination of prefill gas and additional fuelling. However, a startup with an excessive prefill gas will lose the margin of the density control, and a full RE discharge can be triggered when the plasma burn-through fails owing to a high concentration of impurities such as oxygen, if the operational point is marginal to the burn-through limit. The present modelling work implies that preparing the operation with sufficient margins against the failure of impurity burn-through is important for mitigating the risk of unintended plasma termination. Although the carbon wall environment may have a lower risk of RE generation, to alleviate the operational uncertainties of the new device, strategies for expanding the operational window are also discussed in support of JT-60SA initial operation.

When the severe accident or some crucial troubles happen in nuclear power plants, the stop of coolant system and the increase in temperature to far exceeding from the normal operating condition could be predicted. The sudden increase in temperature would change microstructure of structural materials. In order to investigate the influence of annealing on microstructure development, in-situ electron irradiation experiment was carried out in 316L model alloy.Electron irradiation at 288 °C resulted in the formation of black dots, Flank loops and cavities in 316L model alloy. Black dots and Frank loops formed in the early stage of electron-irradiation and transferred to Flank loops and perfect loops, respectively. Annealing experiment at 500 °C for 120 min indicated that the number density and the mean size of Frank loops decreased after annealing. In addition, the mean size of cavities decreased, while the number density seemed not to be changed after annealing. Comparing the size distribution change before and after annealing experiment, it is suggested that Frank loops could be shrunk as a result of absorbing vacancies released from cavities during annealing. Keywords: Electron irradiation, Frank loop, Annealing, 316L

In 2013, we reported that local renin-angiotensin system (local RAS) components express during the hypertrophic differentiation of chondrocytes and can modulate it, using ATDC5 cell line that involves differentiation from mesenchymal stem cells to calcified hypertrophic chondrocytes. However, the expressions of local RAS components in normal chondrocytes have not been revealed yet. The purpose of this study is to examine the expression of the local RAS components in chondrocytes in vivo and the conditions allowing the expression. We stained five major regions of 8-week-old C57BL/6 adult mice in which chondrocytes exist, including epiphyseal plates and hyaline cartilages, with antibodies to local RAS components. We also examined the expression of local RAS components in the cultured bovine’s articular cartilage chondrocytes using quantitative reverse transcription polymerase chain reaction and western blot analysis. In result, hypertrophic chondrocytes of epiphyseal plates included in the tibia and the lamina terminals expressed local RAS components. However, hyaline chondrocytes, including the knee articular cartilages, the parenchyma of nasal septums and of the tracheal walls, did not express local RAS components. Cultured bovine’s articular cartilage chondrocytes also did not express local RAS components. However, inducing hypertrophy by administering interleukin-1β or tumor necrosis factor-α, the cultured articular chondrocytes also expressed angiotensin II type 1 receptor and angiotensin II type 2 receptor. In conclusion, local RAS components express particularly in chondrocytes which occur hypertrophy and do not in hyaline chondrocytes. The results are in accord with our previous in vitro study. We think this novel knowledge is important to investigate cartilage hypertrophy and diseases induced by hypertrophic changes like osteoarthritis.

In developed countries, it is very difficult to demonstrate the effectiveness of pneumococcal vaccines because the incidence of pneumococcal pneumonia is very low. Vaccination against pneumococci infection was advised for 1378 outpatients, over 60 years of age, with chronic respiratory disease for more than one year. Of these patients, those who responded affirmatively to the advice were vaccinated against pneumococci between August and November 2002. The effectiveness of vaccination was evaluated by means of a 2-year cohort-study, comparing the vaccinated group (647) with the non-vaccinated group (731). The variables analyzed were the frequency of onset of bacterial respiratory infection, hospitalization due to bacterial respiratory infection and onset of pneumococcal respiratory infection. The incidence of bacterial respiratory infection and the incidence of pneumococcal respiratory infection to have decreased in the following 2 years (17.4%, 0.9%), as compared to the previous year (25.9%, 3.1%), in the vaccinated group. Conversely, the frequency was higher in the following 2 years (14.4%, 0.9%) as compared to the previous year (14.2%, 0.4%) in the non-vaccinated group. This inter-group difference was statistically significant. Simultaneous vaccination against pneumococci and influenza virus also resulted in a significant reduction in the incidence of bacterial respiratory infection. No decrease was observed in the frequency of hospitalization. These results indicate that pneumococcal vaccine is useful for elderly patients with chronic respiratory disease and that its efficacy may be enhanced by simultaneous vaccination against influenza.

A beam-monitor system for XFEL/SPring 8, “SACLA,” has been constructed. In order to maintain a stable self-amplified spontaneous emission (SASE) interaction, the straightness and overlap of the axes to within 3 μm between the electron beams and the radiated x rays for an undulator section of about 100 m length is necessary. This straightness means relative alignment to an experimental target sample. Furthermore, a temporal stability of 30 fs in order to maintain a constant peak beam current is also necessary to conduct stable SASE lasing. The monitor system was developed to satisfy these spatial and temporal stability and resolution criteria. The system comprises spatial monitors, such as cavity-type beam-position monitors and screen monitors, as well as temporal measurement instruments, such as current monitors, waveguide spectrometers, coherent synchrotron-radiation detectors, a streak camera, and an rf deflector. Commissioning of SACLA started from March 2011, and the monitors performed sufficient roles to tune the beams for lasing. The achieved overall performances of the system, including data acquisition, are: the beam position monitor has a spatial resolution of 600 nm in rms; the bunch-length monitors show ability to observe bunch lengths from 1 ns in an injector with velocity bunching to less than 30 fs after three-stage bunch compressors. The less than 3 μm spatial resolution of the screen monitor was also confirmed during practical beam operation. Owing to these fulfilled performances, such as the high spatial and temporal resolutions, stable lasing of SACLA has been achieved.

This study investigated the effectiveness of an 8-week foot-core exercise training program on foot-ankle kinematics during running and also on running kinetics (impact loads), with particular interest in biomechanical outcomes considered risk factors for running-related injuries in recreational runners. A single-blind, randomized, controlled trial was conducted with 87 recreational runners randomly allocated to either the control (CG) or intervention (IG) group and assessed at baseline and after 8 weeks. The IG underwent foot-core training 3 times/week, while the CG followed a placebo lower-limb stretching protocol. The participants ran on a force-instrumented treadmill at a self-selected speed while foot-segment motion was captured simultaneously with kinetic measurements. After the intervention, there were statistically significant changed in foot biomechanics, such as: IG participants strike the ground with a more inverted calcaneus and a less dorsiflexed midfoot than those in the CG; at midstance, ran with a less plantarflexed and more adducted forefoot and a more abducted hallux; and at push-off, ran with a less dorsiflexed midfoot and a less adducted and more dorsiflexed hallux. The IG runners also had significantly decreased medial longitudinal arch excursion (p = 0.024) and increased rearfoot inversion (p = 0.037). The 8-week foot-core exercise program had no effect on impact (p = 0.129) and breaking forces (p = 0.934) or on vertical loading rate (p = 0.537), but it was positively effective in changing foot-ankle kinematic patterns.”