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2. AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear

Author

Maryna V. Ivanchenko, Killian S. Hanlon, Daniel M. Hathaway, Alex J. Klein, Cole W. Peters, Yaqiao Li, Panos I. Tamvakologos, Josette Nammour, Casey A. Maguire, and David P. Corey

Subjects
inner ear, adeno-associated virus vector, non-human primate, cochlea, hair cells, hereditary deafness, Genetics, QH426-470, Cytology, QH573-671
Abstract

Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even so, there are few AAV capsids that transduce both inner and outer hair cells—the cells that express most deafness genes—and fewer still shown to transduce hair cells efficiently in primates. AAV capsids with robust transduction of inner and outer hair cells in primate cochlea will be needed for most clinical trials. Here, we test a capsid that we previously isolated from a random capsid library, AAV-S, for transduction in mouse and non-human primate inner ear. In both mice and cynomolgus macaques, AAV-S mediates highly efficient reporter gene expression in a variety of cochlear cells, including inner and outer hair cells, fibrocytes, and supporting cells. In a mouse model of Usher syndrome type 3A, AAV-S encoding CLRN1 robustly and durably rescues hearing. Overall, our data indicate that AAV-S is a promising candidate for therapeutic gene delivery to the human inner ear.

Published
2021
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3. Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction

Author

Naomi Chadderton, Arpad Palfi, Daniel M. Maloney, Matthew Carrigan, Laura K. Finnegan, Killian S. Hanlon, Ciara Shortall, Mary O’Reilly, Peter Humphries, Lorraine Cassidy, Paul F. Kenna, Sophia Millington-Ward, and G. Jane Farrar

Subjects
retinal ganglion cell (RGC), gene therapy, AAV, mitochondrial dysfunction, neuroprotection, oxidative stress, Pharmacy and materia medica, RS1-441
Abstract

AAV gene therapy for ocular disease has become a reality with the market authorisation of LuxturnaTM for RPE65-linked inherited retinal degenerations and many AAV gene therapies currently undergoing phase III clinical trials. Many ocular disorders have a mitochondrial involvement from primary mitochondrial disorders such as Leber hereditary optic neuropathy (LHON), predominantly due to mutations in genes encoding subunits of complex I, to Mendelian and multifactorial ocular conditions such as dominant optic atrophy, glaucoma and age-related macular degeneration. In this study, we have optimised the nuclear yeast gene, NADH-quinone oxidoreductase (NDI1), which encodes a single subunit complex I equivalent, creating a candidate gene therapy to improve mitochondrial function, independent of the genetic mutation driving disease. Optimisation of NDI1 (ophNdi1) substantially increased expression in vivo, protected RGCs and increased visual function, as assessed by optokinetic and photonegative response, in a rotenone-induced murine model. In addition, ophNdi1 increased cellular oxidative phosphorylation and ATP production and protected cells from rotenone insult to a significantly greater extent than wild type NDI1. Significantly, ophNdi1 treatment of complex I deficient patient-derived fibroblasts increased oxygen consumption and ATP production rates, demonstrating the potential of ophNdi1 as a candidate therapy for ocular disorders where mitochondrial deficits comprise an important feature.

Published
2023
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4. Selection of an Efficient AAV Vector for Robust CNS Transgene Expression

Author

Killian S. Hanlon, Jonah C. Meltzer, Tetyana Buzhdygan, Ming J. Cheng, Miguel Sena-Esteves, Rachel E. Bennett, Timothy P. Sullivan, Roshanak Razmpour, Yi Gong, Carrie Ng, Josette Nammour, Daniela Maiz, Simon Dujardin, Servio H. Ramirez, Eloise Hudry, and Casey A. Maguire

Subjects
Genetics, QH426-470, Cytology, QH573-671
Abstract

Adeno-associated virus (AAV) capsid libraries have generated improved transgene delivery vectors. We designed an AAV library construct, iTransduce, that combines a peptide library on the AAV9 capsid with a Cre cassette to enable sensitive detection of transgene expression. After only two selection rounds of the library delivered intravenously in transgenic mice carrying a Cre-inducible fluorescent protein, we flow sorted fluorescent cells from brain, and DNA sequencing revealed two dominant capsids. One of the capsids, termed AAV-F, mediated transgene expression in the brain cortex more than 65-fold (astrocytes) and 171-fold (neurons) higher than the parental AAV9. High transduction efficiency was sex-independent and sustained in two mouse strains (C57BL/6 and BALB/c), making it a highly useful capsid for CNS transduction of mice. Future work in large animal models will test the translation potential of AAV-F. Keywords: adeno-associated virus vector, AAV vector, gene therapy, gene delivery, central nervous system, transduction efficiency, AAV capsid library

Published
2019
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5. High levels of AAV vector integration into CRISPR-induced DNA breaks

Author

Killian S. Hanlon, Benjamin P. Kleinstiver, Sara P. Garcia, Mikołaj P. Zaborowski, Adrienn Volak, Stefan E. Spirig, Alissa Muller, Alexander A. Sousa, Shengdar Q. Tsai, Niclas E. Bengtsson, Camilla Lööv, Martin Ingelsson, Jeffrey S. Chamberlain, David P. Corey, Martin J. Aryee, J. Keith Joung, Xandra O. Breakefield, Casey A. Maguire, and Bence György

Subjects
Science
Abstract

In-depth characterization of adeno-associated virus (AAV)-mediated CRISPR delivery is still lacking. Here, the authors show high levels of integration into Cas9-induced double-strand breaks (DSBs) in therapeutically relevant genes in vivo.

Published
2019
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6. Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate

Author

Bence György, Elise J. Meijer, Maryna V. Ivanchenko, Kelly Tenneson, Frederick Emond, Killian S. Hanlon, Artur A. Indzhykulian, Adrienn Volak, K. Domenica Karavitaki, Panos I. Tamvakologos, Mark Vezina, Vladimir K. Berezovskii, Richard T. Born, Maureen O’Brien, Jean-François Lafond, Yvan Arsenijevic, Margaret A. Kenna, Casey A. Maguire, and David P. Corey

Subjects
Genetics, QH426-470, Cytology, QH573-671
Abstract

Hereditary hearing loss often results from mutation of genes expressed by cochlear hair cells. Gene addition using AAV vectors has shown some efficacy in mouse models, but clinical application requires two additional advances. First, new AAV capsids must mediate efficient transgene expression in both inner and outer hair cells of the cochlea. Second, to have the best chance of clinical translation, these new vectors must also transduce hair cells in non-human primates. Here, we show that an AAV9 capsid variant, PHP.B, produces efficient transgene expression of a GFP reporter in both inner and outer hair cells of neonatal mice. We show also that AAV9-PHP.B mediates almost complete transduction of inner and outer HCs in a non-human primate. In a mouse model of Usher syndrome type 3A deafness (gene CLRN1), we use AAV9-PHP.B encoding Clrn1 to partially rescue hearing. Thus, we have identified a vector with promise for clinical treatment of hereditary hearing disorders, and we demonstrate, for the first time, viral transduction of the inner ear of a primate with an AAV vector. Keywords: inner ear, AAV, non-human primate, cochlea, hair cells, adeno-associated virus vector, hereditary deafness, gene delivery

Published
2019
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7. Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression

Author

Thomas S. van Solinge, Erik R. Abels, Lieke L. van de Haar, Killian S. Hanlon, Sybren L. N. Maas, Rosalie Schnoor, Jeroen de Vrij, Xandra O. Breakefield, and Marike L. D. Broekman

Subjects
glioma, glioblastoma, extracellular vesicles, exosomes, tumor microenvironment, Rab27a, Biology (General), QH301-705.5
Abstract

Introduction: Glioma cells exert influence over the tumor-microenvironment in part through the release of extracellular vesicles (EVs), membrane-enclosed structures containing proteins, lipids, and RNAs. In this study, we evaluated the function of Ras-associated protein 27a (Rab27a) in glioma and evaluated the feasibility of assessing its role in EV release in glioma cells in vitro and in vivo.Methods: Rab27a was knocked down via a short hairpin RNA (shRNA) stably expressed in mouse glioma cell line GL261, with a scrambled shRNA as control. EVs were isolated by ultracentrifugation and quantified with Nanoparticle Tracking Analysis (NTA) and Tunable Resistive Pulse Sensing (TRPS). CellTiter-Glo viability assays and cytokine arrays were used to evaluate the impact of Rab27a knockdown. GL261.shRab27a cells and GL261.shControl were implanted into the left striatum of eight mice to assess tumor growth and changes in the tumor microenvironment.Results: Knockdown of Rab27a in GL261 glioma cells decreased the release of small EVs isolated at 100,000 × g in vitro (p = 0.005), but not the release of larger EVs, isolated at 10,000 × g. GL261.shRab27a cells were less viable compared to the scramble control in vitro (p < 0.005). A significant increase in CCL2 expression in shRab27a GL261 cells was also observed (p < 0.001). However, in vivo there was no difference in tumor growth or overall survival between the two groups, while shRab27a tumors showed lower proliferation at the tumor borders. Decreased infiltration of IBA1 positive macrophages and microglia, but not FoxP3 positive regulatory T cells was observed.Conclusion: Rab27a plays an important role in the release of small EVs from glioma cells, and also in their viability and expression of CCL2 in vitro. As interference in Rab27a expression influences glioma cell viability and expression profiles, future studies should be cautious in using the knockdown of Rab27a as a means of studying the role of small EVs in glioma growth.

Published
2020
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8. Delivering AAV to the Central Nervous and Sensory Systems

Author

Casey A. Maguire, Cole Peters, and Killian S. Hanlon

Subjects
0301 basic medicine, Cell type, Transgene, Genetic enhancement, Genetic Vectors, Sensory system, Toxicology, Article, Viral vector, 03 medical and health sciences, 0302 clinical medicine, Mainstream medicine, Humans, Medicine, Transgenes, Nerve Tissue, Mendelian disorders, Gene, Pharmacology, business.industry, Gene Transfer Techniques, Genetic Therapy, Dependovirus, 030104 developmental biology, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

As gene therapy enters mainstream medicine, it is more important than ever to have a grasp of exactly how to leverage it for maximum benefit. The development of new targeting strategies and tools makes treating patients with genetic diseases possible. Many Mendelian disorders are amenable to gene replacement or correction. These often affect post-mitotic tissues, meaning that a single stably expressing therapy can be applied. Recent years have seen the development of a large number of novel viral vectors for delivering specific therapies. These new vectors - predominately recombinant adeno-associated virus (AAV) variants - target nervous tissues with differing efficiencies. This review gives an overview of current gene therapies in the brain, ear, and eye, and describes the optimal approaches, depending on cell type and transgene. Overall, this work aims to serve as a primer for gene therapy in the central nervous and sensory systems.

Published
2021

9. A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors

Author

Killian S. Hanlon, Naomi Chadderton, Arpad Palfi, Alfonso Blanco Fernandez, Peter Humphries, Paul F. Kenna, Sophia Millington-Ward, and G. Jane Farrar

Subjects
retina, promoter, ganglion cell, gene therapy, AAV, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Significant advances in gene therapy have enabled exploration of therapies for inherited retinal disorders, many of which are in preclinical development or clinical evaluation. Gene therapy for retinal conditions has led the way in this growing field. The loss of retinal ganglion cells (RGCs) is a hallmark of a number of retinal disorders. As the field matures innovations that aid in refining therapies and optimizing efficacy are in demand. Gene therapies under development for RGC-related disorders, when delivered with recombinant adeno associated vectors (AAV), have typically been expressed from ubiquitous promoter sequences. Here we describe how a novel promoter from the murine Nefh gene was selected to drive transgene expression in RGCs. The Nefh promoter, in an AAV2/2 vector, was shown to drive preferential EGFP expression in murine RGCs in vivo following intravitreal injection. In contrast, EGFP expression from a CMV promoter was observed not only in RGCs, but throughout the inner nuclear layer and in amacrine cells located within the ganglion cell layer (GCL). Of note, the Nefh promoter sequence is sufficiently compact to be readily accommodated in AAV vectors, where transgene size represents a significant constraint. Moreover, this promoter should in principle provide a more targeted and potentially safer alternative for RGC-directed gene therapies.

Published
2017
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10. AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear

Author

Killian S. Hanlon, Casey A. Maguire, Daniel M. Hathaway, David P. Corey, Alex J. Klein, Josette Nammour, Panos I. Tamvakologos, Yaqiao Li, Maryna V. Ivanchenko, and Cole Peters

Subjects
0301 basic medicine, inner ear, hair cells, Genetic enhancement, Usher syndrome, viruses, cochlea, non-human primate, Gene delivery, Biology, QH426-470, 03 medical and health sciences, Transduction (genetics), adeno-associated virus vector, 0302 clinical medicine, medicine, Genetics, otorhinolaryngologic diseases, Inner ear, hereditary deafness, gene delivery, Molecular Biology, Cochlea, Reporter gene, QH573-671, AAV, medicine.disease, gene therapy, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Capsid, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, sense organs, Cytology
Abstract

Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even so, there are few AAV capsids that transduce both inner and outer hair cells—the cells that express most deafness genes—and fewer still shown to transduce hair cells efficiently in primates. AAV capsids with robust transduction of inner and outer hair cells in primate cochlea will be needed for most clinical trials. Here, we test a capsid that we previously isolated from a random capsid library, AAV-S, for transduction in mouse and non-human primate inner ear. In both mice and cynomolgus macaques, AAV-S mediates highly efficient reporter gene expression in a variety of cochlear cells, including inner and outer hair cells, fibrocytes, and supporting cells. In a mouse model of Usher syndrome type 3A, AAV-S encoding CLRN1 robustly and durably rescues hearing. Overall, our data indicate that AAV-S is a promising candidate for therapeutic gene delivery to the human inner ear., Graphical abstract, Progress toward gene therapy for deafness requires AAV capsids validated for transgene delivery in mouse and non-human primate cochleas, but just one exists. Ivanchenko and colleagues demonstrate that a new capsid, AAV-S, transduces clinically relevant cells in cochleas of both species and mediates robust rescue of hearing in deaf mice.

Published
2021

13. Selection of an Efficient AAV Vector for Robust CNS Transgene Expression

Author

Josette Nammour, Servio H. Ramirez, Tetyana P. Buzhdygan, Simon Dujardin, Casey A. Maguire, Eloise Hudry, Rachel E. Bennett, Ming J. Cheng, Timothy P. Sullivan, Roshanak Razmpour, Daniela Maiz, Miguel Sena-Esteves, Yi Gong, Jonah C. Meltzer, Killian S. Hanlon, and Carrie Ng

Subjects
0301 basic medicine, Genetically modified mouse, lcsh:QH426-470, Genetic enhancement, Transgene, viruses, Gene delivery, Biology, Virus, Article, 03 medical and health sciences, Transduction (genetics), adeno-associated virus vector, 0302 clinical medicine, AAV capsid library, Genetics, gene delivery, lcsh:QH573-671, Peptide library, Molecular Biology, transduction efficiency, lcsh:Cytology, central nervous system, gene therapy, 3. Good health, Cell biology, AAV vector, lcsh:Genetics, 030104 developmental biology, Capsid, 030220 oncology & carcinogenesis, Molecular Medicine
Abstract

Adeno-associated virus (AAV) capsid libraries have generated improved transgene delivery vectors. We designed an AAV library construct, iTransduce, that combines a peptide library on the AAV9 capsid with a Cre cassette to enable sensitive detection of transgene expression. After only two selection rounds of the library delivered intravenously in transgenic mice carrying a Cre-inducible fluorescent protein, we flow sorted fluorescent cells from brain, and DNA sequencing revealed two dominant capsids. One of the capsids, termed AAV-F, mediated transgene expression in the brain cortex more than 65-fold (astrocytes) and 171-fold (neurons) higher than the parental AAV9. High transduction efficiency was sex-independent and sustained in two mouse strains (C57BL/6 and BALB/c), making it a highly useful capsid for CNS transduction of mice. Future work in large animal models will test the translation potential of AAV-F., Graphical Abstract

Published
2019

15. The AAV9 Variant Capsid AAV-F Mediates Widespread Transgene Expression in Nonhuman Primate Spinal Cord After Intrathecal Administration

Author

Duane Bradley Welling, Killian S. Hanlon, James Kim, Anat Stemmer-Rachamimov, Konstantina M. Stankovic, Yi Gong, Carrie Ng, Adam Beharry, Florian Eichler, Casey A. Maguire, Josette Nammour, Ming Cheng, and Kate Hieber

Subjects
Pathology, medicine.medical_specialty, Transgene, Genetic Vectors, Gene delivery, medicine.disease_cause, Intrathecal, 03 medical and health sciences, Mice, 0302 clinical medicine, Capsid, Transduction, Genetic, Genetics, medicine, Animals, Transgenes, Molecular Biology, Adeno-associated virus, Research Articles, 030304 developmental biology, 0303 health sciences, biology, business.industry, Gene Transfer Techniques, Dependovirus, Spinal cord, Macaca fascicularis, medicine.anatomical_structure, Spinal Cord, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Subarachnoid space, Antibody, business
Abstract

Intrathecal delivery of AAV9 into the subarachnoid space has been shown to transduce spinal cord and brain and be less affected by preexisting antibodies, which are lower in cerebral spinal fluid. Still, efficiency of transduction needs to be improved. Recently, we identified a new capsid from a library selection in mice, called AAV-F, that allowed robust transduction of the spinal cord gray matter after lumbar injection. In this study, we test transduction of spinal cord by AAV-F (n = 3) compared to AAV9 (n = 2), using a reporter gene, in cynomolgus monkeys after lumbar intrathecal injection. Using an automated image analysis (IA) approach to sensitively quantitate reporter gene expression in spinal cord, we found that AAV-F capsid mediated slightly higher transgene expression (both in percentages of cells and intensity of immunostaining) in motor neurons and interneurons, in the lumbar and thoracic regions, compared to AAV9. Interestingly, although AAV-F mediated higher transgene expression in spinal cord, the number of genomes in spinal cord and periphery were on average lower for AAV-F than AAV9, which suggest that lower numbers of genomes were able to mediate higher transgene expression in spinal cord with this capsid. In contrast, dorsal root ganglion transduction efficiency was lower for AAV-F compared to AAV9 on average. Interestingly, we also observed transduction of Schwann cells in sciatic nerve in two nonhuman primates injected with AAV-F, but none with AAV9. Overall, our data demonstrate the utility of automated IA for quantitation of AAV transduction in the spinal cord and the favorable on-target:off-target transduction profile suggests that the AAV-F capsid be considered for gene therapy applications focused on treating the spinal cord after intrathecal delivery.

Published
2021

16. High levels of AAV vector integration into CRISPR-induced DNA breaks

Author

Alexander A. Sousa, J. Keith Joung, Casey A. Maguire, Xandra O. Breakefield, Adrienn Volak, Niclas E. Bengtsson, David P. Corey, Martin Ingelsson, Bence György, Martin J. Aryee, Jeffrey S. Chamberlain, Sara P. Garcia, Alissa Muller, Stefan E. Spirig, Camilla Lööv, Benjamin P. Kleinstiver, Killian S. Hanlon, Mikołaj Piotr Zaborowski, and Shengdar Q. Tsai

Subjects
0301 basic medicine, CRISPR-Cas9 genome editing, Male, viruses, General Physics and Astronomy, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy), Genome, Transduction (genetics), Mice, 0302 clinical medicine, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, lcsh:Science, Gene Editing, Neurons, Multidisciplinary, Muscles, Brain, Chromosome Mapping, Dependovirus, Bacteriophage lambda, 3. Good health, Cochlea, Treatment Outcome, 030220 oncology & carcinogenesis, Dna breaks, Gene Targeting, Transgene, Virus Integration, Science, Genetic Vectors, Mice, Transgenic, Computational biology, Biology, General Biochemistry, Genetics and Molecular Biology, Virus, Article, Cell Line, Vector integration, 03 medical and health sciences, Animals, Humans, Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci), DNA Breaks, General Chemistry, Genetic Therapy, Endonucleases, Mice, Inbred C57BL, Targeted gene repair, 030104 developmental biology, Cell culture, lcsh:Q, CRISPR-Cas Systems, Neuroscience
Abstract

Adeno-associated virus (AAV) vectors have shown promising results in preclinical models, but the genomic consequences of transduction with AAV vectors encoding CRISPR-Cas nucleases is still being examined. In this study, we observe high levels of AAV integration (up to 47%) into Cas9-induced double-strand breaks (DSBs) in therapeutically relevant genes in cultured murine neurons, mouse brain, muscle and cochlea. Genome-wide AAV mapping in mouse brain shows no overall increase of AAV integration except at the CRISPR/Cas9 target site. To allow detailed characterization of integration events we engineer a miniature AAV encoding a 465 bp lambda bacteriophage DNA (AAV-λ465), enabling sequencing of the entire integrated vector genome. The integration profile of AAV-465λ in cultured cells display both full-length and fragmented AAV genomes at Cas9 on-target sites. Our data indicate that AAV integration should be recognized as a common outcome for applications that utilize AAV for genome editing., In-depth characterization of adeno-associated virus (AAV)-mediated CRISPR delivery is still lacking. Here, the authors show high levels of integration into Cas9-induced double-strand breaks (DSBs) in therapeutically relevant genes in vivo.

Published
2019

17. Temperature and injection water source influence microbial community structure in four Alaskan North Slope hydrocarbon reservoirs.

Author

Yvette Marisa Piceno, Francine C Reid, Lauren M Tom, Mark E Conrad, Markus eBill, Christopher George Hubbard, Bruce William Fouke, Craig J Graff, Jiabin eHan, William T Stringfellow, Jeremy S Hanlon, Ping eHu, Terry C Hazen, and Gary L Andersen

Subjects
DNA microarray, microbial communities, Stable isotopes, Souring, Petroleum reservoirs, Microbiology, QR1-502
Abstract

A fundamental knowledge of microbial community structure in petroleum reservoirs can improve predictive modeling of these environments. We used hydrocarbon profiles, stable isotopes, and high-density DNA microarray analysis to characterize microbial communities in produced water from four Alaska North Slope hydrocarbon reservoirs. Produced fluids from Schrader Bluff (24-27°C), Kuparuk (47-70°C), Sag River (80°C), and Ivishak (80-83°C) reservoirs were collected, with paired soured/non-soured wells sampled from Kuparuk and Ivishak. Chemical and stable isotope data suggested Schrader Bluff had substantial biogenic methane, whereas methane was mostly thermogenic in deeper reservoirs. Acetoclastic methanogens (Methanosaeta) were most prominent in Schrader Bluff samples, and the combined δD and δ13C values of methane also indicated acetoclastic methanogenesis could be a primary route for biogenic methane. Conversely, hydrogenotrophic methanogens (e.g., Methanobacteriaceae) and sulfide-producing Archaeoglobus and Thermococcus were more prominent in Kuparuk samples. Sulfide-producing microbes were detected in all reservoirs, uncoupled from souring status (e.g., the non-soured Kuparuk samples had higher relative abundances of many sulfate-reducers compared to the soured sample, suggesting sulfate-reducers may be living fermentatively/syntrophically when sulfate is limited). Sulfate abundance via long-term seawater injection resulted in greater relative abundances of Desulfonauticus, Desulfomicrobium, and Desulfuromonas in the soured Ivishak well compared to the non-soured well. In the non-soured Ivishak sample, several taxa affiliated with Thermoanaerobacter and Halomonas predominated. Archaea were not detected in the deepest reservoirs. Functional group taxa differed in relative abundance among reservoirs, likely reflecting differing thermal and/or geochemical influences.

Published
2014
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18. In vivo engineering of lymphocytes after systemic exosome-associated AAV delivery

Author

Casey A. Maguire, Federico Mingozzi, Benjamin P. Kleinstiver, James J. Moon, Killian S. Hanlon, Amine Meliani, Jeya-shree Natasan, Cort B. Breuer, Adrienn Volak, Massachusetts General Hospital [Charlestown, MA, États-Unis], Harvard Medical School [Boston] (HMS), Immunologie moléculaire et biothérapies innovantes, École pratique des hautes études (EPHE)-Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Genethon, Thérapie des maladies du muscle strié, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Massachusetts General Hospital [Boston], This work was supported by the National Institutes of Health (R01-AI107020, R21-AI124143 to J.J.M., and R01-DC017117 to C.A.M.) and the European Research Council (Consolidator Grant 617432 to F.M.)., European Project: 617432,EC:FP7:ERC,ERC-2013-CoG,MOMAAV(2014), Approches génétiques intégrées et nouvelles thérapies pour les maladies rares (INTEGRARE), Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Généthon, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Bodescot, Myriam, and Molecular signatures and Modulation of immunity to Adeno-Associated Virus vectors - MOMAAV - - EC:FP7:ERC2014-07-01 - 2019-06-30 - 617432 - VALID

Subjects
Male, Viral vectors, Genetic enhancement, T cell, T-Lymphocytes, Genetic Vectors, Green Fluorescent Proteins, lcsh:Medicine, [SDV.GEN] Life Sciences [q-bio]/Genetics, Gene delivery, Biology, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Exosomes, Exosome, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, In vivo, Transduction, Genetic, medicine, Animals, Transgenes, lcsh:Science, 030304 developmental biology, 0303 health sciences, [SDV.GEN]Life Sciences [q-bio]/Genetics, Multidisciplinary, lcsh:R, Gene Transfer Techniques, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, Dependovirus, 3. Good health, Mice, Inbred C57BL, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, lcsh:Q, Stem cell, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, Genetic Engineering, CD8
Abstract

Ex-vivo gene therapy using stem cells or T cells transduced by retroviral or lentiviral vectors has shown remarkable efficacy in the treatment of immunodeficiencies and cancer. However, the process is expensive, technically challenging, and not readily scalable to large patient populations, particularly in underdeveloped parts of the world. Direct in vivo gene therapy would avoid these issues, and such approaches with adeno-associated virus (AAV) vectors have been shown to be safe and efficacious in clinical trials for diseases affecting differentiated tissues such as the liver and CNS. However, the ability to transduce lymphocytes with AAV in vivo after systemic delivery has not been carefully explored. Here, we show that both standard and exosome-associated preparations of AAV8 vectors can effectively transduce a variety of immune cell populations including CD4+ T cells, CD8+ T cells, B cells, macrophages, and dendritic cells after systemic delivery in mice. We provide direct evidence of T cell transduction through the detection of AAV genomes and transgene mRNA, and show that intracellular and transmembrane proteins can be expressed. These findings establish the feasibility of AAV-mediated in vivo gene delivery to immune cells which will facilitate both basic and applied research towards the goal of direct in vivo gene immunotherapies.

Published
2020

19. Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate

Author

Frederick Emond, David P. Corey, Bence György, Jean-François Lafond, Kelly Tenneson, Elise J. Meijer, Vladimir K. Berezovskii, Casey A. Maguire, Richard T. Born, Mark Vezina, Panos I. Tamvakologos, Maureen O’Brien, Maryna V. Ivanchenko, Adrienn Volak, Yvan Arsenijevic, K. Domenica Karavitaki, Margaret A. Kenna, Artur A. Indzhykulian, and Killian S. Hanlon

Subjects
0301 basic medicine, inner ear, lcsh:QH426-470, hair cells, Hearing loss, Usher syndrome, Transgene, viruses, cochlea, non-human primate, Gene delivery, Biology, Article, 03 medical and health sciences, Transduction (genetics), adeno-associated virus vector, 0302 clinical medicine, Genetics, medicine, otorhinolaryngologic diseases, Inner ear, lcsh:QH573-671, hereditary deafness, gene delivery, Molecular Biology, Gene, Cochlea, AAV, lcsh:Cytology, medicine.disease, Cell biology, lcsh:Genetics, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Molecular Medicine, sense organs, medicine.symptom
Abstract

Hereditary hearing loss often results from mutation of genes expressed by cochlear hair cells. Gene addition using AAV vectors has shown some efficacy in mouse models, but clinical application requires two additional advances. First, new AAV capsids must mediate efficient transgene expression in both inner and outer hair cells of the cochlea. Second, to have the best chance of clinical translation, these new vectors must also transduce hair cells in non-human primates. Here, we show that an AAV9 capsid variant, PHP.B, produces efficient transgene expression of a GFP reporter in both inner and outer hair cells of neonatal mice. We show also that AAV9-PHP.B mediates almost complete transduction of inner and outer HCs in a non-human primate. In a mouse model of Usher syndrome type 3A deafness (gene CLRN1), we use AAV9-PHP.B encoding Clrn1 to partially rescue hearing. Thus, we have identified a vector with promise for clinical treatment of hereditary hearing disorders, and we demonstrate, for the first time, viral transduction of the inner ear of a primate with an AAV vector. Keywords: inner ear, AAV, non-human primate, cochlea, hair cells, adeno-associated virus vector, hereditary deafness, gene delivery

Published
2018

20. Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea

Author

Frederick Emond, Maya K. Devine, Maryna V. Ivanchenko, David P. Corey, Margaret A. Kenna, Kelly Tenneson, Casey A. Maguire, Jean-François Lafond, and Killian S. Hanlon

Subjects
Primates, 0301 basic medicine, Transgene, Genetic Vectors, Biology, Article, Viral vector, Green fluorescent protein, Mice, 03 medical and health sciences, Transduction (genetics), 0302 clinical medicine, otorhinolaryngologic diseases, medicine, Animals, Inner ear, Transgenes, Cochlea, Vestibular system, Round window, Dependovirus, Sensory Systems, Cell biology, Macaca fascicularis, 030104 developmental biology, medicine.anatomical_structure, sense organs, 030217 neurology & neurosurgery
Abstract

In a number of mouse models of hereditary deafness, therapeutic transgene delivery to the cochlea and vestibular organs using adeno-associated viral vectors (AAVs) has shown striking rescue of hearing and balance. However, only a subset of AAV capsids have shown efficacy in transducing both inner hair cells and outer hair cells, and it is also not clear which of these can be translated to treatment of human inner ear. We recently reported efficient transgene expression of a GFP reporter in a non-human primate cochlea, in both inner and outer hair cells, following injection of the AAV9 capsid variant PHP.B via the round window membrane (RWM). However efficiency was poor at a lower dose. To further define the transduction potential of AAV9-PHP.B, we have performed a dosing study in the cynomolgus monkey and assessed vector-encoded GFP expression. Three animals were injected in both ears and four doses were tested. We describe a transmastoid surgical approach needed to access the RWM of this common primate model. We found that AAV9-PHP.B transduced nearly 100% of both IHCs and OHCs, from base to apex, at the higher doses (3.5 × 1011 and 7 × 1011 vector genomes). However, at lower doses there was a steep reduction in viral transduction. Thus, AAV9-PHP.B efficiently transduces the IHCs and OHCs of nonhuman primates, and should be considered as an AAV capsid for inner ear gene therapy in humans.

Published
2020

21. Evaluation of watershed-derived mass loads to prioritize TMDL decision-making

Author

William T. Stringfellow, Ashley Stubblefield, Mary Kay Camarillo, Chelsea Spier, Jeremy S. Hanlon, and Shelly Gulati

Subjects
Hydrology, geography, Environmental Engineering, geography.geographical_feature_category, Watershed, 0208 environmental biotechnology, 02 engineering and technology, 010501 environmental sciences, Waste Disposal, Fluid, 01 natural sciences, California, 020801 environmental engineering, Oxygen, Rivers, Total maximum daily load, Environmental monitoring, Tributary, Environmental science, Water quality, San Joaquin, Eutrophication, Environmental Monitoring, 0105 earth and related environmental sciences, Water Science and Technology, Main stem
Abstract

A total maximum daily load (TMDL) for oxygen demanding substances is being implemented in the San Joaquin River (SJR) in California (USA) due to frequently occurring low dissolved oxygen conditions. The SJR is a eutrophic river, heavily impacted by agriculture. A mass balance was developed to identify the sources of oxygen-demanding substances and nutrients to the river with the objective of providing a scientific basis for management actions needed to meet TMDL requirements. Data were collected for flow and water quality and mass loads calculated for sites within the main stem of the SJR, river inputs (tributaries), and diversions in the study area. Using a quadrant analysis, tributary flows and loads are ranked to identify targets for water quality improvement efforts. Additionally, all mass loads were summed (inputs minus diversions) and compared with observed loads at the downstream limit of the study area. The mass balance analysis identifies major contributors of mass loads and mass balance closure is assessed for each constituent. These analysis methods inform the TMDL process which includes a load allocation, and is useful for determining locations for implementation of improvement projects needed to improve the health of the river.

Published
2015

22. A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors

Author

Sophia Millington-Ward, Paul F. Kenna, Alfonso Blanco Fernández, Killian S. Hanlon, Naomi Chadderton, G. Jane Farrar, Arpad Palfi, and Peter Humphries

Subjects
0301 basic medicine, retina, ganglion cell, Retinal Disorder, Genetic enhancement, Transgene, Biology, Retinal ganglion, lcsh:RC321-571, 03 medical and health sciences, medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Ganglion cell layer, Original Research, Retina, promoter, General Neuroscience, AAV, gene therapy, Molecular biology, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Retinal ganglion cell, Inner nuclear layer, sense organs, Neuroscience
Abstract

Significant advances in gene therapy have enabled exploration of therapies for inherited retinal disorders, many of which are in preclinical development or clinical evaluation. Gene therapy for retinal conditions has led the way in this growing field. The loss of retinal ganglion cells (RGCs) is a hallmark of a number of retinal disorders. As the field matures innovations that aid in refining therapies and optimizing efficacy are in demand. Gene therapies under development for RGC-related disorders, when delivered with recombinant adeno associated vectors (AAV), have typically been expressed from ubiquitous promoter sequences. Here we describe how a novel promoter from the murine Nefh gene was selected to drive transgene expression in RGCs. The Nefh promoter, in an AAV2/2 vector, was shown to drive preferential EGFP expression in murine RGCs in vivo following intravitreal injection. In contrast, EGFP expression from a CMV promoter was observed not only in RGCs, but throughout the inner nuclear layer and in amacrine cells located within the ganglion cell layer (GCL). Of note, the Nefh promoter sequence is sufficiently compact to be readily accommodated in AAV vectors, where transgene size represents a significant constraint. Moreover, this promoter should in principle provide a more targeted and potentially safer alternative for RGC-directed gene therapies.

Published
2017

23. Intelligent Space Assembly Robot: Design and Ground Testing

Author

Bianca Rubiocastaneda, Edward A. S. Hanlon, Thomas Lai, Dakota L. Wenberg, and Jin Kang

Subjects
Ground testing, 020301 aerospace & aeronautics, 010504 meteorology & atmospheric sciences, 0203 mechanical engineering, Computer science, Control engineering, 02 engineering and technology, Space (commercial competition), 01 natural sciences, Robot design, Simulation, 0105 earth and related environmental sciences, Robot control
Published
2017

24. Search for stop production in R-parity-violating supersymmetry at HERA

Author

S. CHEKANOV, M. DERRICK, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, D. NICHOLASS, J. REPOND, R. YOSHIDA, M. C. K. MATTINGLY, N. PAVEL, A. G. YAGÜES MOLINA, S. ANTONELLI, P. ANTONIOLI, G. BARI, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, F. CINDOLO, M. CORRADI, S. DE PASQUALE, G. IACOBUCCI, A. MARGOTTI, R. NANIA, A. POLINI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, H. P. JAKOB, M. JÜNGST, O. M. KIND, E. PAUL, J. RAUTENBERG, R. RENNER, U. SAMSON, V. SCHÖNBERG, M. WANG, M. WLASENKO, N. H. BROOK, G. P. HEATH, J. D. MORRIS, T. NAMSOO, M. CAPUA, S. FAZIO, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, E. TASSI, J. Y. KIM, K. J. MA, Z. A. IBRAHIM, B. KAMALUDDIN, W. A. T. WAN ABDULLAH, Y. NING, Z. REN, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, M. GIL, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA BOLD, D. KISIELEWSKA, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, A. BONATO, K. BORRAS, N. COPPOLA, J. FOURLETOVA, A. GEISER, D. GLADKOV, P. GÖTTLICHER, I. GREGOR, O. GUTSCHE, T. HAAS, W. HAIN, C. HORN, B. KAHLE, U. KÖTZ, H. KOWALSKI, H. LIM, E. LOBODZINSKA, B. LÖHR, R. MANKEL, I. A. MELZER PELLMANN, A. MONTANARI, C. N. NGUYEN, D. NOTZ, A. E. NUNCIO QUIROZ, R. SANTAMARTA, U. SCHNEEKLOTH, H. STADIE, U. STÖSSLEIN, D. SZUBA, J. SZUBA, T. THEEDT, G. WATT, G. WOLF, K. WRONA, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, P. G. PELFER, A. BAMBERGER, D. DOBUR, F. KARSTENS, N. N. VLASOV, P. J. BUSSEY, A. T. DOYLE, W. DUNNE, J. FERRANDO, S. HANLON, D. H. SAXON, I. O. SKILLICORN, I. GIALAS, T. GOSAU, U. HOLM, R. KLANNER, E. LOHRMANN, H. SALEHI, P. SCHLEPER, T. SCHÖRNER SADENIUS, J. SZTUK, K. WICHMANN, K. WICK, C. FOUDAS, C. FRY, K. R. LONG, A. D. TAPPER, M. KATAOKA, T. MATSUMOTO, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A. N. BARAKBAEV, E. G. BOOS, A. DOSSANOV, N. S. POKROVSKIY, B. O. ZHAUTYKOV, D. SON, J. DE FAVEREAU, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, M. JIMENEZ, L. LABARGA, J. DEL PESO, E. RON, J. TERRÓN, M. ZAMBRANA, F. CORRIVEAU, C. LIU, R. WALSH, C. ZHOU, T. TSURUGAI, A. ANTONOV, B. A. DOLGOSHEIN, I. RUBINSKY, V. SOSNOVTSEV, A. STIFUTKIN, S. SUCHKOV, R. K. DEMENTIEV, P. F. ERMOLOV, L. K. GLADILIN, I. I. KATKOV, L. A. KHEIN, I. A. KORZHAVINA, V. A. KUZMIN, B. B. LEVCHENKO, O. Y.U. LUKINA, A. S. PROSKURYAKOV, L. M. SHCHEGLOVA, D. S. ZOTKIN, S. A. ZOTKIN, I. ABT, C. BÜTTNER, A. CALDWELL, D. KOLLAR, X. LIU, W. B. SCHMIDKE, J. SUTIAK, G. GRIGORESCU, A. KERAMIDAS, E. KOFFEMAN, P. KOOIJMAN, A. PELLEGRINO, H. TIECKE, M. VÁZQUEZ, L. WIGGERS, N. BRÜMMER, B. BYLSMA, L. S. DURKIN, A. LEE, T. Y. LING, P. D. ALLFREY, M. A. BELL, A. M. COOPER SARKAR, A. COTTRELL, R. C. E. DEVENISH, B. FOSTER, C. GWENLAN, K. KORCSAK GORZO, S. PATEL, V. ROBERFROID, A. ROBERTSON, P. B. STRAUB, C. URIBE ESTRADA, R. WALCZAK, P. BELLAN, A. BERTOLIN, R. BRUGNERA, R. CARLIN, R. CIESIELSKI, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, L. STANCO, M. TURCATO, B. Y. OH, A. RAVAL, J. J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, J. E. COLE, J. C. HART, H. ABRAMOWICZ, A. GABAREEN, R. INGBIR, S. KANANOV, A. LEVY, M. KUZE, R. HORI, S. KAGAWA, S. SHIMIZU, T. TAWARA, R. HAMATSU, H. KAJI, S. KITAMURA, O. OTA, Y. D. RI, M. I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, S. FOURLETOV, J. F. MARTIN, J. M. BUTTERWORTH, R. HALL WILTON, T. W. JONES, J. H. LOIZIDES, M. R. SUTTON, C. TARGETT ADAMS, M. WING, B. BRZOZOWSKA, J. CIBOROWSKI, G. GRZELAK, P. KULINSKI, P. LUZNIAK, J. MALKA, R. J. NOWAK, J. M. PAWLAK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A. F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, I. GILLER, D. HOCHMAN, U. KARSHON, E. BROWNSON, T. DANIELSON, A. EVERETT, D. KÇIRA, D. D. REEDER, M. ROSIN, P. RYAN, A. A. SAVIN, W. H. SMITH, H. WOLFE, S. BHADRA, C. D. CATTERALL, Y. CUI, G. HARTNER, S. MENARY, U. NOOR, M. SOARES, J. STANDAGE, J. WHYTE, BASILE, MAURIZIO, BINDI, MARCELLO, CIFARELLI, LUISA, CONTIN, ANDREA, RINALDI, LORENZO, SARTORELLI, GABRIELLA, S. CHEKANOV, M. DERRICK, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, D. NICHOLASS, J. REPOND, R. YOSHIDA, M.C.K. MATTINGLY, N. PAVEL, A.G. YAGÜES MOLINA, S. ANTONELLI, P. ANTONIOLI, G. BARI, M. BASILE, L. BELLAGAMBA, M. BINDI, D. BOSCHERINI, A. BRUNI, G. BRUNI, L. CIFARELLI, F. CINDOLO, A. CONTIN, M. CORRADI, S. DE PASQUALE, G. IACOBUCCI, A. MARGOTTI, R. NANIA, A. POLINI, L. RINALDI, G. SARTORELLI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, H.-P. JAKOB, M. JÜNGST, O.M. KIND, E. PAUL, J. RAUTENBERG, R. RENNER, U. SAMSON, V. SCHÖNBERG, M. WANG, M. WLASENKO, N.H. BROOK, G.P. HEATH, J.D. MORRIS, T. NAMSOO, M. CAPUA, S. FAZIO, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, E. TASSI, J.Y. KIM, K.J. MA, Z.A. IBRAHIM, B. KAMALUDDIN, W.A.T. WAN ABDULLAH, Y. NING, Z. REN, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, M. GIL, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA-BOLD, D. KISIELEWSKA, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, A. BONATO, K. BORRAS, N. COPPOLA, J. FOURLETOVA, A. GEISER, D. GLADKOV, P. GÖTTLICHER, I. GREGOR, O. GUTSCHE, T. HAAS, W. HAIN, C. HORN, B. KAHLE, U. KÖTZ, H. KOWALSKI, H. LIM, E. LOBODZINSKA, B. LÖHR, R. MANKEL, I.-A. MELZER-PELLMANN, A. MONTANARI, C.N. NGUYEN, D. NOTZ, A.E. NUNCIO-QUIROZ, R. SANTAMARTA, U. SCHNEEKLOTH, H. STADIE, U. STÖSSLEIN, D. SZUBA, J. SZUBA, T. THEEDT, G. WATT, G. WOLF, K. WRONA, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, P.G. PELFER, A. BAMBERGER, D. DOBUR, F. KARSTENS, N.N. VLASOV, P.J. BUSSEY, A.T. DOYLE, W. DUNNE, J. FERRANDO, S. HANLON, D.H. SAXON, I.O. SKILLICORN, I. GIALAS, T. GOSAU, U. HOLM, R. KLANNER, E. LOHRMANN, H. SALEHI, P. SCHLEPER, T. SCHÖRNER-SADENIUS, J. SZTUK, K. WICHMANN, K. WICK, C. FOUDAS, C. FRY, K.R. LONG, A.D. TAPPER, M. KATAOKA, T. MATSUMOTO, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A.N. BARAKBAEV, E.G. BOOS, A. DOSSANOV, N.S. POKROVSKIY, B.O. ZHAUTYKOV, D. SON, J. DE FAVEREAU, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, M. JIMENEZ, L. LABARGA, J. DEL PESO, E. RON, J. TERRÓN, M. ZAMBRANA, F. CORRIVEAU, C. LIU, R. WALSH, C. ZHOU, T. TSURUGAI, A. ANTONOV, B.A. DOLGOSHEIN, I. RUBINSKY, V. SOSNOVTSEV, A. STIFUTKIN, S. SUCHKOV, R.K. DEMENTIEV, P.F. ERMOLOV, L.K. GLADILIN, I.I. KATKOV, L.A. KHEIN, I.A. KORZHAVINA, V.A. KUZMIN, B.B. LEVCHENKO, O.YU. LUKINA, A.S. PROSKURYAKOV, L.M. SHCHEGLOVA, D.S. ZOTKIN, S.A. ZOTKIN, I. ABT, C. BÜTTNER, A. CALDWELL, D. KOLLAR, X. LIU, W.B. SCHMIDKE, J. SUTIAK, G. GRIGORESCU, A. KERAMIDAS, E. KOFFEMAN, P. KOOIJMAN, A. PELLEGRINO, H. TIECKE, M. VÁZQUEZ, L. WIGGERS, N. BRÜMMER, B. BYLSMA, L.S. DURKIN, A. LEE, T.Y. LING, P.D. ALLFREY, M.A. BELL, A.M. COOPER-SARKAR, A. COTTRELL, R.C.E. DEVENISH, B. FOSTER, C. GWENLAN, K. KORCSAK-GORZO, S. PATEL, V. ROBERFROID, A. ROBERTSON, P.B. STRAUB, C. URIBE-ESTRADA, R. WALCZAK, P. BELLAN, A. BERTOLIN, R. BRUGNERA, R. CARLIN, R. CIESIELSKI, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, L. STANCO, M. TURCATO, B.Y. OH, A. RAVAL, J.J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, J.E. COLE, J.C. HART, H. ABRAMOWICZ, A. GABAREEN, R. INGBIR, S. KANANOV, A. LEVY, M. KUZE, R. HORI, S. KAGAWA, S. SHIMIZU, T. TAWARA, R. HAMATSU, H. KAJI, S. KITAMURA, O. OTA, Y.D. RI, M.I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, S. FOURLETOV, J.F. MARTIN, J.M. BUTTERWORTH, R. HALL-WILTON, T.W. JONES, J.H. LOIZIDES, M.R. SUTTON, C. TARGETT-ADAMS, M. WING, B. BRZOZOWSKA, J. CIBOROWSKI, G. GRZELAK, P. KULINSKI, P. LUZNIAK, J. MALKA, R.J. NOWAK, J.M. PAWLAK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A.F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, I. GILLER, D. HOCHMAN, U. KARSHON, E. BROWNSON, T. DANIELSON, A. EVERETT, D. KÇIRA, D.D. REEDER, M. ROSIN, P. RYAN, A.A. SAVIN, W.H. SMITH, H. WOLFE, S. BHADRA, C.D. CATTERALL, Y. CUI, G. HARTNER, S. MENARY, U. NOOR, M. SOARES, J. STANDAGE, and J. WHYTE

Subjects
Particle physics, MONTE-CARLO GENERATOR, Physics and Astronomy (miscellaneous), STANDARD MODEL, HERA, FOS: Physical sciences, Lambda, 01 natural sciences, JET FRAGMENTATION, DECAYS, High Energy Physics - Experiment, E(+)E(-) COLLISIONS, High Energy Physics - Experiment (hep-ex), High Energy Physics, ZEUS Collaboration, R-parity, 0103 physical sciences, SCATTERING, ddc:530, 010306 general physics, Engineering (miscellaneous), Physics, E+E-PHYSICS, 010308 nuclear & particles physics, Supergravity, High Energy Physics::Phenomenology, ZEUS BARREL CALORIMETER, Supersymmetry, PHYSICS EVENT GENERATION, Coupling (probability), PARTON DISTRIBUTIONS, Production (computer science), High Energy Physics::Experiment, Minimal Supersymmetric Standard Model
Abstract

A search for stop production in R-parity-violating supersymmetry has been performed in $e^{+}p$ interactions with the ZEUS detector at HERA, using an integrated luminosity of 65 pb$^{-1}$. At HERA, the R-parity-violating coupling $\lambda'$ allows resonant squark production, $e^+d\to\tilde{q}$. Since the lowest-mass squark state in most supersymmetry models is the light stop, $\tilde{t}$, this search concentrated on production of $\tilde{t}$, followed either by a direct R-parity-violating decay, or by the gauge decay to $b\tilde{\chi}^+_{1}$. No evidence for stop production was found and limits were set on $\lambda'_{131}$ as a function of the stop mass in the framework of the Minimal Supersymmetric Standard Model. The results have also been interpreted in terms of constraints on the parameters of the minimal Supergravity model., Comment: 24 pages, 11 figures, 1 table, Accepted by European Physical Journal C

Published
2007

25. Performance of sanitary sewer collection system odour control devices operating in diverse conditions

Author

Jeremy S. Hanlon, Elizabeth Basha, William T. Stringfellow, and Mary Kay Camarillo

Subjects
Environmental Engineering, Sewage, Waste management, Chemistry, Equipment Design, Collection system, United States, Refuse Disposal, Volumetric flow rate, Volume (thermodynamics), Odorants, Oxidizing agent, Service life, medicine, Hydrogen Sulfide, Sanitary sewer, Relief valve, Environmental Monitoring, Water Science and Technology, Activated carbon, medicine.drug
Abstract

Controlling odours from sanitary sewer systems is challenging as a result of the expansive nature of these systems. Addition of oxidizing chemicals is often practiced as a mitigation strategy. One alternative is to remove odorous compounds in the gases vented from manholes using adsorptive media. In this study, odour control devices located at manholes were observed to determine the ability of these systems to reduce hydrogen sulphide from vented gases. The odour control devices incorporated pressure regulation to control gas flow out of manhole covers and adsorptive media to remove hydrogen sulphide in the vented gases prior to release. Pressure regulation was accomplished using a variable volume bladder and two pressure relief valves that permitted gas flow when pressures exceeded 1.3 to 2.5 cm water column. The reduction in gas flow vented from manholes was intended to extend the service life of the adsorptive media, as compared with odour control devices that do not incorporate pressure modulation. Devices were deployed at four locations and three adsorptive media were tested. Although measured collection system hydrogen sulphide concentrations varied from zero to over 1,000 ppm, the removal rates observed using odour control devices were typically above 90%. The lower removal rates observed at one of the sites (50.5 ± 36.1%) appeared related to high gas flow rates being emitted at this location. Activated carbon was used in most of the tests, although use of iron media resulted in the highest removal observed: 97.8 ± 3.6%. The expected service life of the adsorptive media contained within the odour control devices is a function of site-specific hydrogen sulphide concentrations and gas flow rates. The units used in this study were in service for more than 8 to 12 months prior to requiring media replacement.

Published
2013

26. Investigation of selective catalytic reduction for control of nitrogen oxides in full-scale dairy energy production

Author

William T. Stringfellow, Mary Kay Camarillo, Jeremy S. Hanlon, and Kyle A. Watson

Subjects
Mechanical Engineering, Inorganic chemistry, Exhaust gas, Selective catalytic reduction, Building and Construction, Management, Monitoring, Policy and Law, Ammonia, chemistry.chemical_compound, Anaerobic digestion, General Energy, chemistry, Biogas, Environmental chemistry, Urea, Diesel exhaust fluid, NOx
Abstract

Selective catalytic reduction (SCR) was used to reduce exhaust gas nitrogen oxides (NOx) from the emissions of a 710 kW combined heat and power system fueled by dairy biogas. Exhaust gas NOx was reduced from 63.1 ± 31.9 to 14.2 ± 17.5 ppmvd @ 15% O2 such that emissions were 0.33 ± 0.40 g kW � 1 h � 1 , based on data averaged over 15 min intervals. Online exhaust gas sensors with integrated process control algorithms were effective in improving NOx removal by automated control of urea, the ammonia source used for catal- ysis of NOx reduction reactions. Pre-SCR NOx was most strongly correlated with equivalence ratio (R 2 = 0.39), indicative of the air-fuel ratio. A concave relationship between NOx production and thermal conversion efficiency was not observed since lean-burn operation of the engine was consistent and only altered under low engine load. Following installation of pre- and post-SCR NOx sensors, average daily exhaust gas NOx reduction in the SCR was 82.6 ± 8.5%. Post-SCR NOx emissions were typically impacted by pre-SCR NOx (R

Published
2013

28. Economic sustainability of a biomass energy project located at a dairy in California, USA

Author

Michael Jue, William T. Stringfellow, Jeremy S. Hanlon, and Mary Kay Camarillo

Subjects
Engineering, Waste management, Power station, business.industry, Environmental engineering, Greenhouse, Biomass, Management, Monitoring, Policy and Law, Anaerobic digestion, General Energy, Electricity generation, Greenhouse gas, Waste heat, Sustainability, business
Abstract

Previous experience has demonstrated the tenuous nature of biomass energy projects located at livestock facilities in the U.S. In response, the economic sustainability of a 710 kW combined heat and power biomass energy system located on a dairy farm in California was evaluated. This biomass energy facility is unique in that a complete-mix anaerobic digester was used for treatment of manure collected in a flush-water system, co-digestates were used as additional digester feedstocks (whey, waste feed, and plant biomass), and the power plant is operating under strict regulatory requirements for stack gas emissions. Electricity was produced and sold wholesale, and cost savings resulted from the use of waste heat to offset propane demand. The impact of various operational factors was considered in the economic analysis, indicating that the system is economically viable as constructed but could benefit from introduction of additional substrates to increase methane and electricity production, additional utilization of waste heat, sale of digested solids, and possibly pursuing greenhouse gas credits. Use of technology for nitrogen oxide (NO x ) removal had a minimal effect on economic sustainability.

Published
2012

29. Operating an Anaerobic Digestion and Co-Generation System with Stringent Air Quality Regulations to Limit Nitrogen Oxides (NOx) and Sulfur Oxides (SOx) in Stack Gas Emissions

Author

Michael Jue, Mary Kay Camarillo, Jeremy S. Hanlon, and William T. Stringfellow

Subjects
Co generation, Anaerobic digestion, Waste management, chemistry, Stack (abstract data type), General Engineering, Environmental science, chemistry.chemical_element, Gas emissions, Limit (mathematics), Nitrogen oxides, Air quality index, Sulfur
Published
2012

30. Investigation of river eutrophication as part of a low dissolved oxygen total maximum daily load implementation

Author

Russ Brown, Carol Kendall, Joel Herr, Gary M. Litton, Carl W. Chen, Randy A. Dahlgren, Nigel W.T. Quinn, Mark Brunell, William T. Stringfellow, Remie Burks, Sharon Borglin, Jeremy S. Hanlon, and Justin Graham

Subjects
Chlorophyll, Environmental Engineering, Watershed, Models, Biological, California, Rivers, Tributary, Phytoplankton, Animals, Biomass, Environmental Restoration and Remediation, Water Science and Technology, Hydrology, geography, geography.geographical_feature_category, Geography, Chlorophyll A, Estuary, Eutrophication, Plankton, Oxygen, Total maximum daily load, Environmental science, Water quality, Environmental Monitoring
Abstract

In the United States, environmentally impaired rivers are subject to regulation under total maximum daily load (TMDL) regulations that specify watershed wide water quality standards. In California, the setting of TMDL standards is accompanied by the development of scientific and management plans directed at achieving specific water quality objectives. The San Joaquin River (SJR) in the Central Valley of California now has a TMDL for dissolved oxygen (DO). Low DO conditions in the SJR are caused in part by excessive phytoplankton growth (eutrophication) in the shallow, upstream portion of the river that create oxygen demand in the deeper estuary. This paper reports on scientific studies that were conducted to develop a mass balance on nutrients and phytoplankton in the SJR. A mass balance model was developed using WARMF, a model specifically designed for use in TMDL management applications. It was demonstrated that phytoplankton biomass accumulates rapidly in a 88 km reach where plankton from small, slow moving tributaries are diluted and combined with fresh nutrient inputs in faster moving water. The SJR-WARMF model was demonstrated to accurately predict phytoplankton growth in the SJR. Model results suggest that modest reductions in nutrients alone will not limit algal biomass accumulation, but that combined strategies of nutrient reduction and algal control in tributaries may have benefit. The SJR-WARMF model provides stakeholders a practical, scientific tool for setting remediation priorities on a watershed scale.

Published
2009

31. Comparison of wetland and agriculture drainage as sources of biochemical oxygen demand to the San Joaquin River, California

Author

Sharon Borglin, Jeremy S. Hanlon, William T. Stringfellow, and Nigel W.T. Quinn

Subjects
Biochemical oxygen demand, Hydrology, geography, Irrigation, geography.geographical_feature_category, food and beverages, Soil Science, Wetland, Total maximum daily load, Tributary, Environmental science, Water quality, San Joaquin, Drainage, Agronomy and Crop Science, Earth-Surface Processes, Water Science and Technology
Abstract

For many years, the San Joaquin River (SJR) has had low dissolved oxygen conditions intermittently during the late summer and early fall. The low dissolved oxygen conditions are impacting critical fish habitat and the SJR is being regulated under a state of California remediation plan that includes the development of a total maximum daily load (TMDL) allocation for oxygen demanding substances. In support of the development of a scientific TMDL allocation, studies are being conducted to characterize water quality in the many tributaries of the SJR. This study identified the sources of biochemical oxygen demand (BOD) in two western tributaries of the SJR, Mud Slough and Salt Slough, and measured the loads of BOD, algae, and ammonia entering the SJR from wetland and agricultural sources. Mud and Salt Sloughs drain the Grassland Watershed. The watershed contains seasonal wetlands, irrigated farmland, and other agricultural lands. This drainage is under close regulatory scrutiny, because it produces a majority of the selenium and boron entering the SJR. In this study, wetland and irrigated agricultural drainage were sampled separately and a comparison was made to determine differences in water quality. In addition, water entering the study area was compared to water exiting the study area to determine the effect of water use in the region on water quality. This study demonstrated that BOD loads from the Grassland Watershed to the SJR were proportional to flow during June–October, the most critical time for dissolved oxygen deficits in the lower SJR. This indicates that Mud and Salt Sloughs are not producing more BOD than other tributaries in the region that are not under close regulatory scrutiny. The BOD concentration of wetland drainage is higher than that of agricultural drainage, but the higher agricultural drainage flows result in a higher mass loading of BOD. Wetland flooding and irrigation of crops both had a negative impact on water quality. Algal growth was identified as the major source of BOD in agricultural drainage and locations where BOD control could potentially be implemented were identified.

Published
2008

33. Measurement of beauty production in deep inelastic scattering at HERA

Author

F. Sciulli, Kenneth Long, G. Bari, J. Repond, Af Zarnecki, K. C. Voss, Fernando Barreiro, Giovanna Bruni, H.-P. Jakob, M. Barbi, M. Basile, A. Stifutkin, T. Haas, S.I. Suchkov, R. Brugnera, LK Gladilin, Kerstin Borras, V. A. Kuzmin, E. Maddox, S.E.S. Schagen, D. Hochman, C. Youngman, Dong-Chul Son, S. Schlenstedt, P. J. Bussey, Didar Dobur, Elisabetta Gallo, S. Robins, G.P. Heath, M. Rosin, G. Romeo, Marco Schioppa, S. Magill, P. G. Pelfer, Inkyu Park, Leszek Adamczyk, Oliver Gutsche, Alessandro Montanari, Richard Hall-Wilton, H. Kowalski, S Lammers, M.I. Ferrero, P. Bellan, A. Galas, D. Szuba, L. M. Shcheglova, F. Karstens, J. H. Loizides, Allen Caldwell, Katsuo Tokushuku, D. Gladkov, P.F. Ermolov, M. Zambrana, Janusz Chwastowski, E. A. De Wolf, Xiaobing Liu, Luis Labarga, C. Collins-Tooth, K.J. Ma, James Ferrando, Giuseppe Iacobucci, S. Menary, Ada Solano, N. H. Brook, M. Derrick, T. Tymieniecka, P.M. Kooijman, Olga Lukina, N. A. McCubbin, P. Cloth, C.N. Nguyen, Sosnovtsev, H.G.J.M. Tiecke, Z. Ren, S. Limentani, A. Bruni, A. Parenti, T. Yamashita, T. Carli, U. Kötz, Tachishige Hirose, I. Gialas, D. Lelas, J. Ciborowski, A. Pesci, Adler, B. Foster, S. Dusini, Danuta Kisielewska, Anna Mastroberardino, P Ryan, Amanda Cooper-Sarkar, A.E. Nuncio-Quiroz, T. Koop, I. T. Lim, T. Namsoo, N. Pavel, J. J. Whitmore, J. Rautenberg, M. Inuzuka, AA Savin, M. Kowal, A. Kreisel, A. Cottrell, R. J. Nowak, A. Eskreys, A. T. Doyle, B. A. Dolgoshein, J. Szuba, Marta Ruspa, Iwona Grabowska-Bold, R. Yoshida, A. Ziegler, J. Fourletova, A. Antonov, S. Patel, B. B. Levchenko, K. Olkiewicz, T. Tawara, Pietro Antonioli, Luisa Cifarelli, R. K. Dementiev, I. Bloch, A. Benen, M. Vázquez, Ben Bylsma, G. Hartner, Sergei Chekanov, S. Kagawa, Jy Kim, I. A. Melzer-Pellmann, T. Kohno, R Corriveau, A. Longhin, M. Milite, T. Gosau, H. Hartmann, M. Wang, A.S. Proskuryakov, R. Walsh, Dirk-Uwe Bartsch, Michele Arneodo, P. Irrgang, A. Pellegrino, J. F. Martin, J. M. Pawlak, O.M. Kind, S. K. Dhawan, J. E. Cole, R. Renner, Claudia Glasman, G. F. Susinno, K. Nagano, R.C.E. Devenish, S. Stonjek, L. S. Durkin, L. Bellagamba, M. S. Soares, M. Y. Pac, D Kcira, A. Nigro, Chiochia, S. Goers, S. A. Zotkin, A. Garfagnini, Jonathan Butterworth, R. Hamatsu, A. M. Kowal, B. Löhr, Claire Gwenlan, J. Sutiak, G. Aghuzumtsyan, J. Standage, D. Dannheim, Lorenzo Rinaldi, Els Koffeman, Peter Schleper, C. Genta, Luca Stanco, Lev Khein, I. Abt, K. Matsuzawa, S. Kitamura, U. Fricke, Mck Mattingly, D. S. Bailey, S. De Pasquale, G. Grzelak, Halina Abramowicz, J. Tandler, N. Brümmer, J. Del Peso, J. Lukasik, Gy. Wolf, U. Stösslein, K. Wichmann, M. Adamus, A Polini, A. Keramidas, Monaco, C. Büttner, T. Fusayasu, A. Bertolin, A. Raval, P. Giusti, S. Kananov, G. Drews, P. Luzniak, J. de Favereau, C. Targett-Adams, G. Marini, U. Meyer, Wolfram Dietrich Zeuner, A. Bamberger, T. Tsurugai, S. Hanlon, Thomas Schörner-Sadenius, Y. Yamazaki, M. Kuze, Rosario Nania, E. Hilger, F. Palmonari, W. Hain, A. Kotański, J. Hamilton, L. Zawiejski, M. Turcato, H. Salehi, Edouard Boos, Costas Foudas, G. Kramberger, E. Lohrmann, M. Helbich, Jan Figiel, Mariusz Przybycien, M. Corradi, Tomasz Bold, Alexander Tapper, D. Notz, C. A. Heusch, P.B. Straub, E.A. Heaphy, C. D. Catterall, T. W. Jones, A Everett, A. Gabareen, WH Smith, B.Y. Oh, K. Wick, S. Gliga, G. Grigorescu, W.B. Schmidke, L. Suszycki, Andrea Contin, Antonino Zichichi, E. Tassi, H. Kaji, N.S. Pokrovskiy, J. Sztuk, I. O. Skillicorn, S. Bhadra, Marcella Capua, Detlef Filges, S. Padhi, N. Krumnack, S. Miglioranzi, A. Ukleja, L.W. Wiggers, C. Cormack, E. Paul, W. Słomiński, B.O. Zhautykov, A. N. Barakbaev, Marco Costa, Ulf Behrens, Federico Cindolo, C. Horn, J. Ukleja, O. González, Rainer Mankel, Achim Geiser, N.N. Vlasov, Juan Terron, M Wing, M. Posocco, B. Kahle, J. Lainesse, Roberto Carlin, S Hillert, Lightwood, U. Holm, M. Kataoka, Krzysztof Piotrzkowski, H. Lim, N. Coppola, DD Reeder, John Hart, F. Metlica, A. Mirea, B. Musgrave, D.G. Stairs, Katkov, S. Yamada, U. Schneekloth, Y. Iga, U. Karshon, D. Boscherini, Liang Li, P. Stopa, Ian Brock, Y. Ning, H. Labes, S. Fourletov, D. H. Saxon, P. Göttlicher, P. Danilov, Roberto Sacchi, Aharon Levy, Anselmo Margotti, Sutton, I. A. Korzhavina, M. Riveline, G. D'Agostini, T. Y. Ling, Pawel Plucinski, R. Gonçalo, Y. Eisenberg, R. Walczak, Giuseppe Barbagli, R. Ciesielski, G. Sartorelli, F. Dal Corso, S.J.L.A. Grijpink, S. Chekanov, M. Derrick, D. Krakauer, J.H. Loizides 1, S. Magill, B. Musgrave, J. Repond, R. Yoshida, M.C.K. Mattingly, P. Antonioli, G. Bari, M. Basile, L. Bellagamba, D. Boscherini, A. Bruni, G. Bruni, G. Cara Romeo, L. Cifarelli, F. Cindolo, A. Contin, M. Corradi, S. De Pasquale, P. Giusti, G. Iacobucci, A. Margotti, A. Montanari, R. Nania, F. Palmonari, A. Pesci, L. Rinaldi, G. Sartorelli, A. Zichichi, G. Aghuzumtsyan, D. Bartsch, I. Brock, S. Goer, H. Hartmann, E. Hilger, P. Irrgang, H., Zeus (IHEF, IoP, FNWI), and UCL - SC/PHYS - Département de physique

Subjects
Particle physics, Nuclear and High Energy Physics, ROOT S=1.8 TEV, HERA, P(P)OVER-BAR COLLISIONS, FOS: Physical sciences, Inelastic scattering, Jet (particle physics), 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), High Energy Physics, ZEUS Collaboration, CENTRAL TRACKING DETECTOR, PRODUCTION CROSS-SECTION, CARLO GENERATOR CASCADE, BOTTOM-QUARK PRODUCTION, HADRON-COLLISIONS, HEAVY QUARKS, ZEUS BARREL, B-MESONS, 0103 physical sciences, 010306 general physics, Nuclear Experiment, QC, Physics, Quantum chromodynamics, Muon, ZEUS (particle detector), 010308 nuclear & particles physics, Deep inelastic scattering, Pair production, High Energy Physics::Experiment
Abstract

The beauty production cross section for deep inelastic scattering events with at least one hard jet in the Breit frame together with a muon has been measured, for photon virtualities Q^2 > 2 GeV^2, with the ZEUS detector at HERA using integrated luminosity of 72 pb^-1. The total visible cross section is sigma_b-bbar (ep -> e jet mu X) = 40.9 +- 5.7 (stat.) +6.0 -4.4 (syst.) pb. The next-to-leading order QCD prediction lies about 2.5 standard deviations below the data. The differential cross sections are in general consistent with the NLO QCD predictions; however at low values of Q^2, Bjorken x, and muon transverse momentum, and high values of jet transverse energy and muon pseudorapidity, the prediction is about two standard deviations below the data., 18 pages, 4 figures

Published
2004
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34. Evidence for a narrow baryonic state decaying to K0Sp and K0Sp̄ in deep inelastic scattering at HERA

Author

S. Chekanov, M. Derrick, J.H. Loizides, S. Magill, S. Miglioranzi, B. Musgrave, J. Repond, R. Yoshida, M.C.K. Mattingly, N. Pavel, P. Antonioli, G. Bari, M. Basile, L. Bellagamba, D. Boscherini, A. Bruni, G. Bruni, G. Cara Romeo, L. Cifarelli, F. Cindolo, A. Contin, M. Corradi, S. De Pasquale, P. Giusti, G. Iacobucci, A. Margotti, A. Montanari, R. Nania, F. Palmonari, A. Pesci, L. Rinaldi, G. Sartorelli, A. Zichichi, G. Aghuzumtsyan, D. Bartsch, I. Brock, S. Goers, H. Hartmann, E. Hilger, P. Irrgang, H.-P. Jakob, O. Kind, U. Meyer, E. Paul, J. Rautenberg, R. Renner, A. Stifutkin, J. Tandler, K.C. Voss, M. Wang, D.S. Bailey, N.H. Brook, J.E. Cole, G.P. Heath, T. Namsoo, S. Robins, M. Wing, M. Capua, A. Mastroberardino, M. Schioppa, G. Susinno, J.Y. Kim, I.T. Lim, K.J. Ma, M.Y. Pac, M. Helbich, Y. Ning, Z. Ren, W.B. Schmidke, F. Sciulli, J. Chwastowski, A. Eskreys, J. Figiel, A. Galas, K. Olkiewicz, P. Stopa, L. Zawiejski, L. Adamczyk, T. Bołd, I. Grabowska-Bołd, D. Kisielewska, A.M. Kowal, M. Kowal, J. Łukasik, M. Przybycień, L. Suszycki, D. Szuba, J. Szuba, A. Kotański, W. Słomiński, V. Adler, U. Behrens, I. Bloch, K. Borras, V. Chiochia, D. Dannheim, G. Drews, J. Fourletova, U. Fricke, A. Geiser, P. Göttlicher, O. Gutsche, T. Haas, W. Hain, S. Hillert, C. Horn, B. Kahle, U. Kötz, H. Kowalski, G. Kramberger, H. Labes, D. Lelas, H. Lim, B. Löhr, R. Mankel, I.-A. Melzer-Pellmann, C.N. Nguyen, D. Notz, A.E. Nuncio-Quiroz, A. Polini, A. Raval, L. Rurua, U. Schneekloth, U. Stösslein, G. Wolf, C. Youngman, W. Zeuner, S. Schlenstedt, G. Barbagli, E. Gallo, C. Genta, P.G. Pelfer, A. Bamberger, A. Benen, F. Karstens, D. Dobur, N.N. Vlasov, M. Bell, P.J. Bussey, A.T. Doyle, J. Ferrando, J. Hamilton, S. Hanlon, D.H. Saxon, I.O. Skillicorn, I. Gialas, T. Carli, T. Gosau, U. Holm, N. Krumnack, E. Lohrmann, M. Milite, H. Salehi, P. Schleper, T. Schörner-Sadenius, S. Stonjek, K. Wichmann, K. Wick, A. Ziegler, Ar. Ziegler, C. Collins-Tooth, C. Foudas, R. Gonçalo, K.R. Long, A.D. Tapper, P. Cloth, D. Filges, M. Kataoka, K. Nagano, K. Tokushuku, S. Yamada, Y. Yamazaki, A.N. Barakbaev, E.G. Boos, N.S. Pokrovskiy, B.O. Zhautykov, D. Son, K. Piotrzkowski, F. Barreiro, C. Glasman, O. González, L. Labarga, J. del Peso, E. Tassi, J. Terrón, M. Zambrana, M. Barbi, F. Corriveau, S. Gliga, J. Lainesse, S. Padhi, D.G. Stairs, R. Walsh, T. Tsurugai, A. Antonov, P. Danilov, B.A. Dolgoshein, D. Gladkov, V. Sosnovtsev, S. Suchkov, R.K. Dementiev, P.F. Ermolov, I.I. Katkov, L.A. Khein, I.A. Korzhavina, V.A. Kuzmin, B.B. Levchenko, O.Yu. Lukina, A.S. Proskuryakov, L.M. Shcheglova, S.A. Zotkin, I. Abt, C. Büttner, A. Caldwell, X. Liu, J. Sutiak, N. Coppola, S. Grijpink, E. Koffeman, P. Kooijman, E. Maddox, A. Pellegrino, S. Schagen, H. Tiecke, M. Vázquez, L. Wiggers, E. de Wolf, N. Brümmer, B. Bylsma, L.S. Durkin, T.Y. Ling, A.M. Cooper-Sarkar, A. Cottrell, R.C.E. Devenish, B. Foster, G. Grzelak, C. Gwenlan, T. Kohno, S. Patel, P.B. Straub, R. Walczak, A. Bertolin, R. Brugnera, R. Carlin, F. Dal Corso, S. Dusini, A. Garfagnini, S. Limentani, A. Longhin, A. Parenti, M. Posocco, L. Stanco, M. Turcato, E.A. Heaphy, F. Metlica, B.Y. Oh, J.J. Whitmore, Y. Iga, G. D'Agostini, G. Marini, A. Nigro, C. Cormack, J.C. Hart, N.A. McCubbin, C. Heusch, I.H. Park, H. Abramowicz, A. Gabareen, S. Kananov, A. Kreisel, A. Levy, M. Kuze, T. Fusayasu, S. Kagawa, T. Tawara, T. Yamashita, R. Hamatsu, T. Hirose, M. Inuzuka, H. Kaji, S. Kitamura, K. Matsuzawa, M. Costa, M.I. Ferrero, V. Monaco, R. Sacchi, A. Solano, M. Arneodo, M. Ruspa, T. Koop, J.F. Martin, A. Mirea, J.M. Butterworth, R. Hall-Wilton, T.W. Jones, M.S. Lightwood, M.R. Sutton, C. Targett-Adams, J. Ciborowski, R. Ciesielski, P. Łużniak, R.J. Nowak, J.M. Pawlak, J. Sztuk, T. Tymieniecka, A. Ukleja, J. Ukleja, A.F. Żarnecki, M. Adamus, P. Plucinski, Y. Eisenberg, D. Hochman, U. Karshon, M. Riveline, A. Everett, L.K. Gladilin, D. Kçira, S. Lammers, L. Li, D.D. Reeder, M. Rosin, P. Ryan, A.A. Savin, W.H. Smith, S. Dhawan, S. Bhadra, C.D. Catterall, S. Fourletov, G. Hartner, S. Menary, M. Soares, J. Standage, Zeus (IHEF, IoP, FNWI), and UCL - SC/PHYS - Département de physique

Subjects
Physics, Particle physics, Nuclear and High Energy Physics, Luminosity (scattering theory), 010308 nuclear & particles physics, Hadron, FOS: Physical sciences, HERA, Inelastic scattering, Deep inelastic scattering, 01 natural sciences, Resonance (particle physics), Pentaquark, 3. Good health, High Energy Physics - Experiment, Nuclear physics, Baryon, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, High Energy Physics::Experiment, 010306 general physics, Nuclear Experiment
Abstract

A resonance search has been made in the K0s p and K0s pbar invariant-mass spectrum measured with the ZEUS detector at HERA using an integrated luminosity of 121 pb-1. The search was performed in the central rapidity region of inclusive deep inelastic scattering at an ep centre-of-mass energy of 300-318 GeV for exchanged photon virtuality, Q2, above 1 GeV2. Recent results from fixed-target experiments give evidence for a narrow baryon resonance decaying to K+ n and K0s p, interpreted as a pentaquark. The results presented here support the existence of such state, with a mass of 1521.5+/-1.5(stat.)^{+2.8}_{-1.7}(syst.) MeV and a Gaussian width consistent with the experimental resolution of 2 MeV. The signal is visible at high Q2 and, for Q2>20 GeV2, contains 221+/-48 events. The probability of a similar signal anywhere in the range 1500-1560 MeV arising from fluctuations of the background is below 6x10^{-5}., 4 eps figures, 15 pages, 1 table, accepted by Physics Letters B

Published
2004
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35. Scaling violations and determination of αs from jet production in γp interactions at HERA

Author

S Chekanov, D Krakauer, J.H Loizides, S Magill, B Musgrave, J Repond, R Yoshida, M.C.K Mattingly, P Antonioli, G Bari, M Basile, L Bellagamba, D Boscherini, A Bruni, G Bruni, G Cara Romeo, L Cifarelli, F Cindolo, A Contin, M Corradi, S De Pasquale, P Giusti, G Iacobucci, A Margotti, R Nania, F Palmonari, A Pesci, G Sartorelli, A Zichichi, G Aghuzumtsyan, D Bartsch, I Brock, S Goers, H Hartmann, E Hilger, P Irrgang, H.-P Jakob, A Kappes, U.F Katz, O Kind, E Paul, J Rautenberg, R Renner, H Schnurbusch, A Stifutkin, J Tandler, K.C Voss, M Wang, A Weber, D.S Bailey, N.H Brook, J.E Cole, B Foster, G.P Heath, H.F Heath, S Robins, E Rodrigues, J Scott, R.J Tapper, M Wing, M Capua, A Mastroberardino, M Schioppa, G Susinno, J.Y Kim, Y.K Kim, J.H Lee, I.T Lim, M.Y Pac, A Caldwell, M Helbich, X Liu, B Mellado, Y Ning, S Paganis, Z Ren, W.B Schmidke, F Sciulli, J Chwastowski, A Eskreys, J Figiel, K Olkiewicz, P Stopa, L Zawiejski, L Adamczyk, T Bołd, I Grabowska-Bołd, D Kisielewska, A.M Kowal, M Kowal, T Kowalski, M Przybycień, L Suszycki, D Szuba, J Szuba, A Kotański, W Słomiński, L.A.T Bauerdick, U Behrens, I Bloch, K Borras, V Chiochia, D Dannheim, M Derrick, G Drews, J Fourletova, A Fox-Murphy, U Fricke, A Geiser, F Goebel, P Göttlicher, O Gutsche, T Haas, W Hain, G.F Hartner, S Hillert, U Kötz, H Kowalski, G Kramberger, H Labes, D Lelas, B Löhr, R Mankel, I.-A Melzer-Pellmann, M Moritz, D Notz, M.C Petrucci, A Polini, A Raval, U Schneekloth, F Selonke, H Wessoleck, R Wichmann, G Wolf, C Youngman, W Zeuner, A Lopez-Duran Viani, A Meyer, S Schlenstedt, G Barbagli, E Gallo, C Genta, P.G Pelfer, A Bamberger, A Benen, N Coppola, M Bell, P.J Bussey, A.T Doyle, C Glasman, J Hamilton, S Hanlon, S.W Lee, A Lupi, D.H Saxon, I.O Skillicorn, I Gialas, B Bodmann, T Carli, U Holm, K Klimek, N Krumnack, E Lohrmann, M Milite, H Salehi, S Stonjek, K Wick, A Ziegler, Ar Ziegler, C Collins-Tooth, C Foudas, R Gonçalo, K.R Long, F Metlica, A.D Tapper, P Cloth, D Filges, M Kuze, K Nagano, K Tokushuku, S Yamada, Y Yamazaki, A.N Barakbaev, E.G Boos, N.S Pokrovskiy, B.O Zhautykov, H Lim, D Son, F Barreiro, O González, L Labarga, J del Peso, I Redondo, E Tassi, J Terrón, M Vázquez, M Barbi, A Bertolin, F Corriveau, S Gliga, J Lainesse, S Padhi, D.G Stairs, T Tsurugai, A Antonov, P Danilov, B.A Dolgoshein, D Gladkov, V Sosnovtsev, S Suchkov, R.K Dementiev, P.F Ermolov, Yu.A Golubkov, I.I Katkov, L.A Khein, I.A Korzhavina, V.A Kuzmin, B.B Levchenko, O.Yu Lukina, A.S Proskuryakov, L.M Shcheglova, N.N Vlasov, S.A Zotkin, C Bokel, J Engelen, S Grijpink, E Koffeman, P Kooijman, E Maddox, A Pellegrino, S Schagen, H Tiecke, N Tuning, J.J Velthuis, L Wiggers, E de Wolf, N Brümmer, B Bylsma, L.S Durkin, T.Y Ling, S Boogert, A.M Cooper-Sarkar, R.C.E Devenish, J Ferrando, G Grzelak, T Matsushita, M Rigby, O Ruske, M.R Sutton, R Walczak, R Brugnera, R Carlin, F Dal Corso, S Dusini, A Garfagnini, S Limentani, A Longhin, A Parenti, M Posocco, L Stanco, M Turcato, E.A Heaphy, B.Y Oh, P.R.B Saull, J.J Whitmore, Y Iga, G D'Agostini, G Marini, A Nigro, C Cormack, J.C Hart, N.A McCubbin, C Heusch, I.H Park, N Pavel, H Abramowicz, A Gabareen, S Kananov, A Kreisel, A Levy, T Abe, T Fusayasu, S Kagawa, T Kohno, T Tawara, T Yamashita, R Hamatsu, T Hirose, M Inuzuka, S Kitamura, K Matsuzawa, T Nishimura, M Arneodo, M.I Ferrero, V Monaco, M Ruspa, R Sacchi, A Solano, R Galea, T Koop, G.M Levman, J.F Martin, A Mirea, A Sabetfakhri, J.M Butterworth, C Gwenlan, R Hall-Wilton, T.W Jones, M.S Lightwood, B.J West, J Ciborowski, R Ciesielski, R.J Nowak, J.M Pawlak, B Smalska, J Sztuk, T Tymieniecka, A Ukleja, J Ukleja, A.F Żarnecki, M Adamus, P Plucinski, Y Eisenberg, L.K Gladilin, D Hochman, U Karshon, D Kçira, S Lammers, L Li, D.D Reeder, A.A Savin, W.H Smith, A Deshpande, S Dhawan, V.W Hughes, P.B Straub, S Bhadra, C.D Catterall, S Fourletov, S Menary, M Soares, and J Standage

Subjects
Physics, Quantum chromodynamics, Nuclear and High Energy Physics, Particle physics, Jet (fluid), ZEUS (particle detector), Luminosity (scattering theory), 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, HERA, Deep inelastic scattering, 01 natural sciences, Particle identification, Nuclear physics, Pseudorapidity, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics
Abstract

Differential cross sections for jet photoproduction in the reaction ep→e jet X have been measured with the ZEUS detector at HERA using 82.2 pb−1 of integrated luminosity. Inclusive jet cross sections are presented as a function of the jet transverse energy, ETjet, for jets with ETjet>17 GeV and pseudorapidity −1

Published
2003

36. Temperature and injection water source influence microbial community structure in four Alaskan North Slope hydrocarbon reservoirs

Author

Jiabin Han, Francine C. Reid, William T. Stringfellow, Craig J. Graff, Lauren M. Tom, Ping Hu, Yvette M. Piceno, Mark E. Conrad, Christopher G. Hubbard, Gary L. Andersen, Terry C. Hazen, Markus Bill, Bruce W. Fouke, and Jeremy S. Hanlon

Subjects
Microbiology (medical), reservoir, Methanogenesis, Souring, lcsh:QR1-502, microbial communities, Microbiology, Methane, lcsh:Microbiology, chemistry.chemical_compound, stomatognathic system, Original Research Article, Relative species abundance, Stable isotopes, Petroleum reservoirs, petroleum, phylochip, biology, δ13C, Ecology, Stable isotope ratio, DNA microarray, biology.organism_classification, chemistry, Microbial population biology, Environmental chemistry, Archaea
Abstract

A fundamental knowledge of microbial community structure in petroleum reservoirs can improve predictive modeling of these environments. We used hydrocarbon profiles, stable isotopes, and high-density DNA microarray analysis to characterize microbial communities in produced water from four Alaskan North Slope hydrocarbon reservoirs. Produced fluids from Schrader Bluff (24-27°C), Kuparuk (47-70°C), Sag River (80°C), and Ivishak (80-83°C) reservoirs were collected, with paired soured/non-soured wells sampled from Kuparuk and Ivishak. Chemical and stable isotope data suggested Schrader Bluff had substantial biogenic methane, whereas methane was mostly thermogenic in deeper reservoirs. Acetoclastic methanogens (Methanosaeta) were most prominent in Schrader Bluff samples, and the combined δD and δ(13)C values of methane also indicated acetoclastic methanogenesis could be a primary route for biogenic methane. Conversely, hydrogenotrophic methanogens (e.g., Methanobacteriaceae) and sulfide-producing Archaeoglobus and Thermococcus were more prominent in Kuparuk samples. Sulfide-producing microbes were detected in all reservoirs, uncoupled from souring status (e.g., the non-soured Kuparuk samples had higher relative abundances of many sulfate-reducers compared to the soured sample, suggesting sulfate-reducers may be living fermentatively/syntrophically when sulfate is limited). Sulfate abundance via long-term seawater injection resulted in greater relative abundances of Desulfonauticus, Desulfomicrobium, and Desulfuromonas in the soured Ivishak well compared to the non-soured well. In the non-soured Ivishak sample, several taxa affiliated with Thermoanaerobacter and Halomonas predominated. Archaea were not detected in the deepest reservoirs. Functional group taxa differed in relative abundance among reservoirs, likely reflecting differing thermal and/or geochemical influences.

Published
2014

37. Photoproduction of events with rapidity gaps between jets at HERA

Author

S. CHEKANOV, M. DERRICK, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, D. NICHOLASS, J. REPOND, R. YOSHIDA, M. C. K. MATTINGLY, N. PAVEL, A. G. YAGÜES MOLINA, P. ANTONIOLI, G. BARI, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, F. CINDOLO, M. CORRADI, S. DE PASQUALE, G. IACOBUCCI, A. MARGOTTI, R. NANIA, A. POLINI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, H. P. JAKOB, M. JÜNGST, O. M. KIND, E. PAUL, J. RAUTENBERG, R. RENNER, U. SAMSON, V. SCHÖNBERG, M. WANG, M. WLASENKO, N. H. BROOK, G. P. HEATH, J. D. MORRIS, T. NAMSOO, M. CAPUA, S. FAZIO, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, E. TASSI, J. Y. KIM, K. J. MA, Z. A. IBRAHIM, B. KAMALUDDIN, W. A. T. WAN ABDULLAH, Y. NING, Z. REN, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, M. GIL, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA BOLD, D. KISIELEWSKA, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, A. BONATO, K. BORRAS, N. COPPOLA, J. FOURLETOVA, A. GEISER, D. GLADKOV, P. GÖTTLICHER, I. GREGOR, O. GUTSCHE, T. HAAS, W. HAIN, C. HORN, B. KAHLE, U. KÖTZ, H. KOWALSKI, H. LIM, E. LOBODZINSKA, B. LÖHR, R. MANKEL, I. A. MELZER PELLMANN, A. MONTANARI, C. N. NGUYEN, D. NOTZ, A. E. NUNCIO QUIROZ, R. SANTAMARTA, U. SCHNEEKLOTH, H. STADIE, U. STÖSSLEIN, D. SZUBA, J. SZUBA, T. THEEDT, G. WATT, G. WOLF, K. WRONA, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, P. G. PELFER, A. BAMBERGER, D. DOBUR, F. KARSTENS, N. N. VLASOV, P. J. BUSSEY, A. T. DOYLE, W. DUNNE, J. FERRANDO, S. HANLON, D. H. SAXON, I. O. SKILLICORN, I. GIALAS, T. GOSAU, U. HOLM, R. KLANNER, E. LOHRMANN, H. SALEHI, P. SCHLEPER, T. SCHÖRNER SADENIUS, J. SZTUK, K. WICHMANN, K. WICK, C. FOUDAS, C. FRY, K. R. LONG, A. D. TAPPER, M. KATAOKA, T. MATSUMOTO, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A. N. BARAKBAEV, E. G. BOOS, A. DOSSANOV, N. S. POKROVSKIY, B. O. ZHAUTYKOV, D. SON, J. DE FAVEREAU, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, M. JIMENEZ, L. LABARGA, J. DEL PESO, E. RON, J. TERRÓN, M. ZAMBRANA, F. CORRIVEAU, C. LIU, R. WALSH, C. ZHOU, T. TSURUGAI, A. ANTONOV, B. A. DOLGOSHEIN, I. RUBINSKY, V. SOSNOVTSEV, A. STIFUTKIN, S. SUCHKOV, R. K. DEMENTIEV, P. F. ERMOLOV, L. K. GLADILIN, I. I. KATKOV, L. A. KHEIN, I. A. KORZHAVINA, V. A. KUZMIN, B. B. LEVCHENKO, O. Y.U. LUKINA, A. S. PROSKURYAKOV, L. M. SHCHEGLOVA, D. S. ZOTKIN, S. A. ZOTKIN, I. ABT, C. BÜTTNER, A. CALDWELL, D. KOLLAR, X. LIU, W. B. SCHMIDKE, J. SUTIAK, G. GRIGORESCU, A. KERAMIDAS, E. KOFFEMAN, P. KOOIJMAN, A. PELLEGRINO, H. TIECKE, M. VÁZQUEZ, L. WIGGERS, N. BRÜMMER, B. BYLSMA, L. S. DURKIN, A. LEE, T. Y. LING, P. D. ALLFREY, M. A. BELL, A. M. COOPER SARKAR, A. COTTRELL, R. C. E. DEVENISH, B. FOSTER, C. GWENLAN, K. KORCSAK GORZO, S. PATEL, V. ROBERFROID, A. ROBERTSON, P. B. STRAUB, C. URIBE ESTRADA, R. WALCZAK, P. BELLAN, A. BERTOLIN, R. BRUGNERA, R. CARLIN, R. CIESIELSKI, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, L. STANCO, M. TURCATO, B. Y. OH, A. RAVAL, J. J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, J. E. COLE, J. C. HART, H. ABRAMOWICZ, A. GABAREEN, R. INGBIR, S. KANANOV, A. LEVY, M. KUZE, R. HORI, S. KAGAWA, S. SHIMIZU, T. TAWARA, R. HAMATSU, H. KAJI, S. KITAMURA, O. OTA, Y. D. RI, M. I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, S. FOURLETOV, J. F. MARTIN, J. M. BUTTERWORTH, R. HALL WILTON, T. W. JONES, J. H. LOIZIDES, M. R. SUTTON, C. TARGETT ADAMS, M. WING, B. BRZOZOWSKA, J. CIBOROWSKI, G. GRZELAK, P. KULINSKI, P. LUZNIAK, J. MALKA, R. J. NOWAK, J. M. PAWLAK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A. F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, I. GILLER, D. HOCHMAN, U. KARSHON, E. BROWNSON, T. DANIELSON, A. EVERETT, D. KÇIRA, D. D. REEDER, M. ROSIN, P. RYAN, A. A. SAVIN, W. H. SMITH, H. WOLFE, S. BHADRA, C. D. CATTERALL, Y. CUI, G. HARTNER, S. MENARY, U. NOOR, M. SOARES, J. STANDAGE, J. WHYTE, ANTONELLI, STEFANO, BASILE, MAURIZIO, BINDI, MARCELLO, CIFARELLI, LUISA, CONTIN, ANDREA, RINALDI, LORENZO, SARTORELLI, GABRIELLA, S. CHEKANOV, M. DERRICK, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, D. NICHOLASS, J. REPOND, R. YOSHIDA, M.C.K. MATTINGLY, N. PAVEL, A.G. YAGÜES MOLINA, S. ANTONELLI, P. ANTONIOLI, G. BARI, M. BASILE, L. BELLAGAMBA, M. BINDI, D. BOSCHERINI, A. BRUNI, G. BRUNI, L. CIFARELLI, F. CINDOLO, A. CONTIN, M. CORRADI, S. DE PASQUALE, G. IACOBUCCI, A. MARGOTTI, R. NANIA, A. POLINI, L. RINALDI, G. SARTORELLI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, H.-P. JAKOB, M. JÜNGST, O.M. KIND, E. PAUL, J. RAUTENBERG, R. RENNER, U. SAMSON, V. SCHÖNBERG, M. WANG, M. WLASENKO, N.H. BROOK, G.P. HEATH, J.D. MORRIS, T. NAMSOO, M. CAPUA, S. FAZIO, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, E. TASSI, J.Y. KIM, K.J. MA, Z.A. IBRAHIM, B. KAMALUDDIN, W.A.T. WAN ABDULLAH, Y. NING, Z. REN, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, M. GIL, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA-BOLD, D. KISIELEWSKA, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, A. BONATO, K. BORRAS, N. COPPOLA, J. FOURLETOVA, A. GEISER, D. GLADKOV, P. GÖTTLICHER, I. GREGOR, O. GUTSCHE, T. HAAS, W. HAIN, C. HORN, B. KAHLE, U. KÖTZ, H. KOWALSKI, H. LIM, E. LOBODZINSKA, B. LÖHR, R. MANKEL, I.-A. MELZER-PELLMANN, A. MONTANARI, C.N. NGUYEN, D. NOTZ, A.E. NUNCIO-QUIROZ, R. SANTAMARTA, U. SCHNEEKLOTH, H. STADIE, U. STÖSSLEIN, D. SZUBA, J. SZUBA, T. THEEDT, G. WATT, G. WOLF, K. WRONA, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, P.G. PELFER, A. BAMBERGER, D. DOBUR, F. KARSTENS, N.N. VLASOV, P.J. BUSSEY, A.T. DOYLE, W. DUNNE, J. FERRANDO, S. HANLON, D.H. SAXON, I.O. SKILLICORN, I. GIALAS, T. GOSAU, U. HOLM, R. KLANNER, E. LOHRMANN, H. SALEHI, P. SCHLEPER, T. SCHÖRNER-SADENIUS, J. SZTUK, K. WICHMANN, K. WICK, C. FOUDAS, C. FRY, K.R. LONG, A.D. TAPPER, M. KATAOKA, T. MATSUMOTO, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A.N. BARAKBAEV, E.G. BOOS, A. DOSSANOV, N.S. POKROVSKIY, B.O. ZHAUTYKOV, D. SON, J. DE FAVEREAU, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, M. JIMENEZ, L. LABARGA, J. DEL PESO, E. RON, J. TERRÓN, M. ZAMBRANA, F. CORRIVEAU, C. LIU, R. WALSH, C. ZHOU, T. TSURUGAI, A. ANTONOV, B.A. DOLGOSHEIN, I. RUBINSKY, V. SOSNOVTSEV, A. STIFUTKIN, S. SUCHKOV, R.K. DEMENTIEV, P.F. ERMOLOV, L.K. GLADILIN, I.I. KATKOV, L.A. KHEIN, I.A. KORZHAVINA, V.A. KUZMIN, B.B. LEVCHENKO, O.YU. LUKINA, A.S. PROSKURYAKOV, L.M. SHCHEGLOVA, D.S. ZOTKIN, S.A. ZOTKIN, I. ABT, C. BÜTTNER, A. CALDWELL, D. KOLLAR, X. LIU, W.B. SCHMIDKE, J. SUTIAK, G. GRIGORESCU, A. KERAMIDAS, E. KOFFEMAN, P. KOOIJMAN, A. PELLEGRINO, H. TIECKE, M. VÁZQUEZ, L. WIGGERS, N. BRÜMMER, B. BYLSMA, L.S. DURKIN, A. LEE, T.Y. LING, P.D. ALLFREY, M.A. BELL, A.M. COOPER-SARKAR, A. COTTRELL, R.C.E. DEVENISH, B. FOSTER, C. GWENLAN, K. KORCSAK-GORZO, S. PATEL, V. ROBERFROID, A. ROBERTSON, P.B. STRAUB, C. URIBE-ESTRADA, R. WALCZAK, P. BELLAN, A. BERTOLIN, R. BRUGNERA, R. CARLIN, R. CIESIELSKI, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, L. STANCO, M. TURCATO, B.Y. OH, A. RAVAL, J.J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, J.E. COLE, J.C. HART, H. ABRAMOWICZ, A. GABAREEN, R. INGBIR, S. KANANOV, A. LEVY, M. KUZE, R. HORI, S. KAGAWA, S. SHIMIZU, T. TAWARA, R. HAMATSU, H. KAJI, S. KITAMURA, O. OTA, Y.D. RI, M.I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, S. FOURLETOV, J.F. MARTIN, J.M. BUTTERWORTH, R. HALL-WILTON, T.W. JONES, J.H. LOIZIDES, M.R. SUTTON, C. TARGETT-ADAMS, M. WING, B. BRZOZOWSKA, J. CIBOROWSKI, G. GRZELAK, P. KULINSKI, P. LUZNIAK, J. MALKA, R.J. NOWAK, J.M. PAWLAK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A.F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, I. GILLER, D. HOCHMAN, U. KARSHON, E. BROWNSON, T. DANIELSON, A. EVERETT, D. KÇIRA, D.D. REEDER, M. ROSIN, P. RYAN, A.A. SAVIN, W.H. SMITH, H. WOLFE, S. BHADRA, C.D. CATTERALL, Y. CUI, G. HARTNER, S. MENARY, U. NOOR, M. SOARES, J. STANDAGE, and J. WHYTE

Subjects
Particle physics, Physics and Astronomy (miscellaneous), Monte Carlo method, HERA, P(P)OVER-BAR COLLISIONS, COLOR-SINGLET EXCHANGE, FOS: Physical sciences, 01 natural sciences, Zeus (malware), High Energy Physics - Experiment, CROSS-SECTIONS, ENERGY, High Energy Physics - Experiment (hep-ex), High Energy Physics, ZEUS Collaboration, 0103 physical sciences, ddc:530, Rapidity, 010306 general physics, Nuclear Experiment, Engineering (miscellaneous), Physics, Luminosity (scattering theory), CENTRAL TRACKING DETECTOR, ZEUS BARREL CALORIMETER, (P)OVER-BAR-P COLLISIONS, ELASTIC-SCATTERING, HADRON-COLLISIONS, CONSTRUCTION, 010308 nuclear & particles physics, Transverse plane, Pseudorapidity, High Energy Physics::Experiment, Energy (signal processing)
Abstract

The photoproduction of dijet events, where the two jets with the highest transverse energy are separated by a large gap in pseudorapidity, have been studied with the ZEUS detector using an integrated luminosity of 39 pb$^{-1}$. Rapidity-gap events are defined in terms of the energy flow between the jets, such that the total summed transverse energy in this region is less than some value $E_{\rm T}^{\rm CUT}$. The data show a clear excess over the predictions of standard photoproduction models. This is interpreted as evidence for a strongly interacting exchange of a color-singlet object. Monte Carlo models which include such a color-singlet exchange are able to describe the data., Comment: 28 pages, 13 figures, accepted by EPJ C

Published
2007

38. An NLO QCD analysis of inclusive cross-section and jet-production data from the ZEUS experiment

Author

S. CHEKANOV, M. DERRICK, J. H. LOIZIDES, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M. C. K. MATTINGLY, N. PAVEL, P. ANTONIOLI, G. BARI, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, F. CINDOLO, M. CORRADI, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, S. DE PASQUALE, A. PESCI, G. CARA ROMEO, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H. P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, A. STIFUTKIN, J. TANDLER, K. C. VOSS, M. WANG, D. S. BAILEY, N. H. BROOK, J. E. COLE, G. P. HEATH, T. NAMSOO, S. ROBINS, M. WING, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, J. Y. KIM, I. T. LIM, K. J. MA, M. Y. PAC, M. HELBICH, Y. NING, Z. REN, W. B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA BOLD, D. KISIELEWSKA, A. M. KOWAL, M. KOWAL, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, D. SZUBA, J. SZUBA, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, V. CHIOCHIA, D. DANNHEIM, G. DREWS, J. FOURLETOVA, U. FRICKE, A. GEISER, P. GOTTLICHER, O. GUTSCHE, T. HAAS, W. HAIN, S. HILLERT, C. HORN, B. KAHLE, U. KOTZ, H. KOWALSKI, G. KRAMBERGER, H. LABES, D. LELAS, H. LIM, B. LOHR, R. MANKEL, I. A. MELZER PELLMANN, C. N. NGUYEN, D. NOTZ, A. E. NUNCIO QUIROZ, A. POLINI, A. RAVAL, L. RURUA, U. SCHNEEKLOTH, U. STOSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, D. DOBUR, F. KARSTENS, N. N. VLASOV, M. BELL, P. J. BUSSEY, A. T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D. H. SAXON, I. O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHORNER SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, A.R. ZIEGLER, C. COLLINS TOOTH, C. FOUDAS, R. GONCALO, K. R. LONG, A. D. TAPPER, P. CLOTH, D. FILGES, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A. N. BARAKBAEV, E. G. BOOS, N. S. POKROVSKIY, B. O. ZHAUTYKOV, D. SON, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZALEZ, L. LABARGA, J. DEL PESO, E. TASSI, J. TERRON, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, S. GLIGA, J. LAINESSE, S. PADHI, D. G. STAIRS, R. WALSH, T. TSURUGAI, A. ANTONOV, P. DANILOV, B. A. DOLGOSHEIN, D. GLADKOV, V. SOSNOVTSEV, S. SUCHKOV, R. K. DEMENTIEV, P. F. ERMOLOV, I. I. KATKOV, L. A. KHEIN, I. A. KORZHAVINA, V. A. KUZMIN, B. B. LEVCHENKO, O. Y.U. LUKINA, A. S. PROSKURYAKOV, L. M. SHCHEGLOVA, S. A. ZOTKIN, I. ABT, C. BUTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, S. GRIJPINK, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, MONICA L. VAZQUEZ, L. WIGGERS, E. DE WOLF, N. BRUMMER, B. BYLSMA, L. S. DURKIN, T. Y. LING, A. M. COOPER SARKAR, A. COTTRELL, R. C. E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P. B. STRAUB, R. WALCZAK, A. BERTOLIN, R. BRUGNERA, R. CARLIN, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, A. PARENTI, M. POSOCCO, L. STANCO, M. TURCATO, E. A. HEAPHY, F. METLICA, B. Y. OH, J. J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, C. CORMACK, J. C. HART, N. A. MCCUBBIN, C. HEUSCH, I. H. PARK, H. ABRAMOWICZ, A. GABAREEN, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, T. FUSAYASU, S. KAGAWA, T. TAWARA, T. YAMASHITA, R. HAMATSU, T. HIROSE, M. INUZUKA, H. KAJI, S. KITAMURA, K. MATSUZAWA, M. COSTA, M. I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, T. KOOP, J. F. MARTIN, A. MIREA, J. M. BUTTERWORTH, R. HALL WILTON, T. W. JONES, M. S. LIGHTWOOD, M. R. SUTTON, C. TARGETT ADAMS, J. CIBOROWSKI, R. CIESIELSKI, P. LUZNIAK, R. J. NOWAK, J. M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A. F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. RIVELINE, A. EVERETT, L. K. GLADILIN, D. KCIRA, S. LAMMERS, L. LI, D. D. REEDER, M. ROSIN, P. RYAN, A. A. SAVIN, W. H. SMITH, S. DHAWAN, S. BHADRA, C. D. CATTERALL, S. FOURLETOV, G. HARTNER, S. MENARY, M. SOARES, J. STANDAGE, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, PALMONARI, FEDERICO, RINALDI, LORENZO, SARTORELLI, GABRIELLA, ZICHICHI, ANTONINO, S. CHEKANOV, M. DERRICK, J.H. LOIZIDES, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M.C.K. MATTINGLY, N. PAVEL, P. ANTONIOLI, G. BARI, M. BASILE, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, L. CIFARELLI, F. CINDOLO, A. CONTIN, M. CORRADI, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, F. PALMONARI, S. DE PASQUALE, A. PESCI, L. RINALDI, G. CARA ROMEO, G. SARTORELLI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H.-P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, A. STIFUTKIN, J. TANDLER, K.C. VOSS, M. WANG, D.S. BAILEY, N.H. BROOK, J.E. COLE, G.P. HEATH, T. NAMSOO, S. ROBINS, M. WING, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, J.Y. KIM, I.T. LIM, K.J. MA, M.Y. PAC, M. HELBICH, Y. NING, Z. REN, W.B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA-BOLD, D. KISIELEWSKA, A.M. KOWAL, M. KOWAL, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, D. SZUBA, J. SZUBA, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, V. CHIOCHIA, D. DANNHEIM, G. DREWS, J. FOURLETOVA, U. FRICKE, A. GEISER, P. GOTTLICHER, O. GUTSCHE, T. HAAS, W. HAIN, S. HILLERT, C. HORN, B. KAHLE, U. KOTZ, H. KOWALSKI, G. KRAMBERGER, H. LABES, D. LELAS, H. LIM, B. LOHR, R. MANKEL, I.-A. MELZER-PELLMANN, C.N. NGUYEN, D. NOTZ, A.E. NUNCIO-QUIROZ, A. POLINI, A. RAVAL, L. RURUA, U. SCHNEEKLOTH, U. STOSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, D. DOBUR, F. KARSTENS, N.N. VLASOV, M. BELL, P.J. BUSSEY, A.T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D.H. SAXON, I.O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHORNER-SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, AR. ZIEGLER, C. COLLINS-TOOTH, C. FOUDAS, R. GONCALO, K.R. LONG, A.D. TAPPER, P. CLOTH, D. FILGES, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A.N. BARAKBAEV, E.G. BOOS, N.S. POKROVSKIY, B.O. ZHAUTYKOV, D. SON, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZALEZ, L. LABARGA, J. DEL PESO, E. TASSI, J. TERRON, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, S. GLIGA, J. LAINESSE, S. PADHI, D.G. STAIRS, R. WALSH, T. TSURUGAI, A. ANTONOV, P. DANILOV, B.A. DOLGOSHEIN, D. GLADKOV, V. SOSNOVTSEV, S. SUCHKOV, R.K. DEMENTIEV, P.F. ERMOLOV, I.I. KATKOV, L.A. KHEIN, I.A. KORZHAVINA, V.A. KUZMIN, B.B. LEVCHENKO, O.YU. LUKINA, A.S. PROSKURYAKOV, L.M. SHCHEGLOVA, S.A. ZOTKIN, I. ABT, C. BUTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, S. GRIJPINK, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, MONICA L. VAZQUEZ, L. WIGGERS, E. DE WOLF, N. BRUMMER, B. BYLSMA, L.S. DURKIN, T.Y. LING, A.M. COOPER-SARKAR, A. COTTRELL, R.C.E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P.B. STRAUB, R. WALCZAK, A. BERTOLIN, R. BRUGNERA, R. CARLIN, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, A. PARENTI, M. POSOCCO, L. STANCO, M. TURCATO, E.A. HEAPHY, F. METLICA, B.Y. OH, J.J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, C. CORMACK, J.C. HART, N.A. MCCUBBIN, C. HEUSCH, I.H. PARK, H. ABRAMOWICZ, A. GABAREEN, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, T. FUSAYASU, S. KAGAWA, T. TAWARA, T. YAMASHITA, R. HAMATSU, T. HIROSE, M. INUZUKA, H. KAJI, S. KITAMURA, K. MATSUZAWA, M. COSTA, M.I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, T. KOOP, J.F. MARTIN, A. MIREA, J.M. BUTTERWORTH, R. HALL-WILTON, T.W. JONES, M.S. LIGHTWOOD, M.R. SUTTON, C. TARGETT-ADAMS, J. CIBOROWSKI, R. CIESIELSKI, P. LUZNIAK, R.J. NOWAK, J.M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A.F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. RIVELINE, A. EVERETT, L.K. GLADILIN, D. KCIRA, S. LAMMERS, L. LI, D.D. REEDER, M. ROSIN, P. RYAN, A.A. SAVIN, W.H. SMITH, S. DHAWAN, S. BHADRA, C.D. CATTERALL, S. FOURLETOV, G. HARTNER, S. MENARY, M. SOARES, and J. STANDAGE

Subjects
Particle physics, Physics and Astronomy (miscellaneous), HERA, FOS: Physical sciences, Parton, Jet (particle physics), 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), High Energy Physics, ZEUS Collaboration, High Energy Physics - Phenomenology (hep-ph), 0103 physical sciences, 010306 general physics, Engineering (miscellaneous), Charged current, Quantum chromodynamics, Physics, ZEUS (particle detector), 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Deep inelastic scattering, Gluon, High Energy Physics - Phenomenology, High Energy Physics::Experiment
Abstract

The ZEUS inclusive differential cross-section data from HERA, for charged and neutral current processes taken with e+ and e- beams, together with differential cross-section data on inclusive jet production in e+ p scattering and dijet production in \gamma p scattering, have been used in a new NLO QCD analysis to extract the parton distribution functions of the proton. The input of jet data constrains the gluon and allows an accurate extraction of \alpha_s(M_Z) at NLO; \alpha_s(M_Z) = 0.1183 \pm 0.0028(exp.) \pm 0.0008(model) An additional uncertainty from the choice of scales is estimated as \pm 0.005. This is the first extraction of \alpha_s(M_Z) from HERA data alone., Comment: 37 pages, 14 figures, to be submitted to EPJC. PDFs available at http://durpdg.dur.ac.uk/hepdata in LHAPDFv4

Published
2005
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39. Search for lepton-flavor violation at HERA

Author

S. CHEKANOV, M. DERRICK, J. H. LOIZIDES, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M. C. K. MATTINGLY, N. PAVEL, P. ANTONIOLI, G. BARI, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, F. CINDOLO, M. CORRADI, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, S. DE PASQUALE, A. PESCI, G. CARA ROMEO, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H. P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, A. STIFUTKIN, J. TANDLER, K. C. VOSS, M. WANG, D. S. BAILEY, N. H. BROOK, J. E. COLE, G. P. HEATH, T. NAMSOO, S. ROBINS, M. WING, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, J. Y. KIM, I. T. LIM, K. J. MA, M. Y. PAC, M. HELBICH, Y. NING, Z. REN, W. B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA BOLD, D. KISIELEWSKA, A. M. KOWAL, M. KOWAL, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, D. SZUBA, J. SZUBA, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, V. CHIOCHIA, D. DANNHEIM, G. DREWS, J. FOURLETOVA, U. FRICKE, A. GEISER, P. GOTTLICHER, O. GUTSCHE, T. HAAS, W. HAIN, S. HILLERT, C. HORN, B. KAHLE, U. KOTZ, H. KOWALSKI, G. KRAMBERGER, H. LABES, D. LELAS, H. LIM, B. LOHR, R. MANKEL, I. A. MELZER PELLMANN, C. N. NGUYEN, D. NOTZ, A. E. NUNCIO QUIROZ, A. POLINI, A. RAVAL, L. RURUA, U. SCHNEEKLOTH, U. STOSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, D. DOBUR, F. KARSTENS, N. N. VLASOV, M. BELL, P. J. BUSSEY, A. T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D. H. SAXON, I. O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHORNER SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, A.R. ZIEGLER, C. COLLINS TOOTH, C. FOUDAS, R. GONCALO, K. R. LONG, A. D. TAPPER, P. CLOTH, D. FILGES, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A. N. BARAKBAEV, E. G. BOOS, N. S. POKROVSKIY, B. O. ZHAUTYKOV, D. SON, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZALEZ, L. LABARGA, J. DEL PESO, E. TASSI, J. TERRON, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, S. GLIGA, J. LAINESSE, S. PADHI, D. G. STAIRS, R. WALSH, T. TSURUGAI, A. ANTONOV, P. DANILOV, B. A. DOLGOSHEIN, D. GLADKOV, V. SOSNOVTSEV, S. SUCHKOV, R. K. DEMENTIEV, P. F. ERMOLOV, I. I. KATKOV, L. A. KHEIN, I. A. KORZHAVINA, V. A. KUZMIN, B. B. LEVCHENKO, O. Y.U. LUKINA, A. S. PROSKURYAKOV, L. M. SHCHEGLOVA, S. A. ZOTKIN, I. ABT, C. BUTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, S. GRIJPINK, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, MONICA L. VAZQUEZ, L. WIGGERS, E. DE WOLF, N. BRUMMER, B. BYLSMA, L. S. DURKIN, T. Y. LING, A. M. COOPER SARKAR, A. COTTRELL, R. C. E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P. B. STRAUB, R. WALCZAK, A. BERTOLIN, R. BRUGNERA, R. CARLIN, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, A. PARENTI, M. POSOCCO, L. STANCO, M. TURCATO, E. A. HEAPHY, F. METLICA, B. Y. OH, J. J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, C. CORMACK, J. C. HART, N. A. MCCUBBIN, C. HEUSCH, I. H. PARK, H. ABRAMOWICZ, A. GABAREEN, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, T. FUSAYASU, S. KAGAWA, T. TAWARA, T. YAMASHITA, R. HAMATSU, T. HIROSE, M. INUZUKA, H. KAJI, S. KITAMURA, K. MATSUZAWA, M. COSTA, M. I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, T. KOOP, J. F. MARTIN, A. MIREA, J. M. BUTTERWORTH, R. HALL WILTON, T. W. JONES, M. S. LIGHTWOOD, M. R. SUTTON, C. TARGETT ADAMS, J. CIBOROWSKI, R. CIESIELSKI, P. LUZNIAK, R. J. NOWAK, J. M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A. F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. RIVELINE, A. EVERETT, L. K. GLADILIN, D. KCIRA, S. LAMMERS, L. LI, D. D. REEDER, M. ROSIN, P. RYAN, A. A. SAVIN, W. H. SMITH, S. DHAWAN, S. BHADRA, C. D. CATTERALL, S. FOURLETOV, G. HARTNER, S. MENARY, M. SOARES, J. STANDAGE, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, PALMONARI, FEDERICO, RINALDI, LORENZO, SARTORELLI, GABRIELLA, ZICHICHI, ANTONINO, UCL, S. CHEKANOV, M. DERRICK, J.H. LOIZIDES, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M.C.K. MATTINGLY, N. PAVEL, P. ANTONIOLI, G. BARI, M. BASILE, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, L. CIFARELLI, F. CINDOLO, A. CONTIN, M. CORRADI, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, F. PALMONARI, S. DE PASQUALE, A. PESCI, L. RINALDI, G. CARA ROMEO, G. SARTORELLI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H.-P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, A. STIFUTKIN, J. TANDLER, K.C. VOSS, M. WANG, D.S. BAILEY, N.H. BROOK, J.E. COLE, G.P. HEATH, T. NAMSOO, S. ROBINS, M. WING, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, J.Y. KIM, I.T. LIM, K.J. MA, M.Y. PAC, M. HELBICH, Y. NING, Z. REN, W.B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA-BOLD, D. KISIELEWSKA, A.M. KOWAL, M. KOWAL, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, D. SZUBA, J. SZUBA, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, V. CHIOCHIA, D. DANNHEIM, G. DREWS, J. FOURLETOVA, U. FRICKE, A. GEISER, P. GOTTLICHER, O. GUTSCHE, T. HAAS, W. HAIN, S. HILLERT, C. HORN, B. KAHLE, U. KOTZ, H. KOWALSKI, G. KRAMBERGER, H. LABES, D. LELAS, H. LIM, B. LOHR, R. MANKEL, I.-A. MELZER-PELLMANN, C.N. NGUYEN, D. NOTZ, A.E. NUNCIO-QUIROZ, A. POLINI, A. RAVAL, L. RURUA, U. SCHNEEKLOTH, U. STOSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, D. DOBUR, F. KARSTENS, N.N. VLASOV, M. BELL, P.J. BUSSEY, A.T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D.H. SAXON, I.O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHORNER-SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, AR. ZIEGLER, C. COLLINS-TOOTH, C. FOUDAS, R. GONCALO, K.R. LONG, A.D. TAPPER, P. CLOTH, D. FILGES, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A.N. BARAKBAEV, E.G. BOOS, N.S. POKROVSKIY, B.O. ZHAUTYKOV, D. SON, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZALEZ, L. LABARGA, J. DEL PESO, E. TASSI, J. TERRON, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, S. GLIGA, J. LAINESSE, S. PADHI, D.G. STAIRS, R. WALSH, T. TSURUGAI, A. ANTONOV, P. DANILOV, B.A. DOLGOSHEIN, D. GLADKOV, V. SOSNOVTSEV, S. SUCHKOV, R.K. DEMENTIEV, P.F. ERMOLOV, I.I. KATKOV, L.A. KHEIN, I.A. KORZHAVINA, V.A. KUZMIN, B.B. LEVCHENKO, O.YU. LUKINA, A.S. PROSKURYAKOV, L.M. SHCHEGLOVA, S.A. ZOTKIN, I. ABT, C. BUTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, S. GRIJPINK, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, MONICA L. VAZQUEZ, L. WIGGERS, E. DE WOLF, N. BRUMMER, B. BYLSMA, L.S. DURKIN, T.Y. LING, A.M. COOPER-SARKAR, A. COTTRELL, R.C.E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P.B. STRAUB, R. WALCZAK, A. BERTOLIN, R. BRUGNERA, R. CARLIN, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, A. PARENTI, M. POSOCCO, L. STANCO, M. TURCATO, E.A. HEAPHY, F. METLICA, B.Y. OH, J.J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, C. CORMACK, J.C. HART, N.A. MCCUBBIN, C. HEUSCH, I.H. PARK, H. ABRAMOWICZ, A. GABAREEN, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, T. FUSAYASU, S. KAGAWA, T. TAWARA, T. YAMASHITA, R. HAMATSU, T. HIROSE, M. INUZUKA, H. KAJI, S. KITAMURA, K. MATSUZAWA, M. COSTA, M.I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, T. KOOP, J.F. MARTIN, A. MIREA, J.M. BUTTERWORTH, R. HALL-WILTON, T.W. JONES, M.S. LIGHTWOOD, M.R. SUTTON, C. TARGETT-ADAMS, J. CIBOROWSKI, R. CIESIELSKI, P. LUZNIAK, R.J. NOWAK, J.M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A.F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. RIVELINE, A. EVERETT, L.K. GLADILIN, D. KCIRA, S. LAMMERS, L. LI, D.D. REEDER, M. ROSIN, P. RYAN, A.A. SAVIN, W.H. SMITH, S. DHAWAN, S. BHADRA, C.D. CATTERALL, S. FOURLETOV, G. HARTNER, S. MENARY, M. SOARES, and J. STANDAGE

Subjects
Quark, Particle physics, Physics and Astronomy (miscellaneous), High Energy Physics::Lattice, HERA, FOS: Physical sciences, Lambda, 01 natural sciences, DECAYS, CROSS-SECTIONS, High Energy Physics - Experiment, Nuclear physics, DEEP-INELASTIC SCATTERING, High Energy Physics - Experiment (hep-ex), High Energy Physics, ZEUS Collaboration, EP COLLISIONS, 0103 physical sciences, EVENT GENERATOR, 010306 general physics, Engineering (miscellaneous), Event generator, Physics, Coupling constant, CENTRAL TRACKING DETECTOR, ZEUS BARREL CALORIMETER, OF-MASS ENERGY, HADRON-COLLISIONS, LEPTOQUARKS, 010308 nuclear & particles physics, Branching fraction, High Energy Physics::Phenomenology, Deep inelastic scattering, High Energy Physics::Experiment, Lepton
Abstract

A search for lepton-flavor-violating interactions $e p \to \mu X $ and $e p\to \tau X $ has been performed with the ZEUS detector using the entire HERA I data sample, corresponding to an integrated luminosity of 130 pb^{-1}. The data were taken at center-of-mass energies, $\sqrt{s}$, of 300 and 318 GeV. No evidence of lepton-flavor violation was found, and constraints were derived on leptoquarks (LQs) that could mediate such interactions. For LQ masses below $\sqrt{s}$, limits were set on $\lambda_{eq_1} \sqrt{\beta_{\ell q}}$, where $\lambda_{eq_1}$ is the coupling of the LQ to an electron and a first-generation quark $q_1$, and $\beta_{\ell q}$ is the branching ratio of the LQ to the final-state lepton $\ell$ ($\mu$ or $\tau$) and a quark $q$. For LQ masses much larger than $\sqrt{s}$, limits were set on the four-fermion interaction term $\lambda_{e q_\alpha} \lambda_{\ell q_\beta} / M_{\mathrm{LQ}}^2$ for LQs that couple to an electron and a quark $q_\alpha$ and to a lepton $\ell$ and a quark $q_\beta$, where $\alpha$ and $\beta$ are quark generation indices. Some of the limits are also applicable to lepton-flavor-violating processes mediated by squarks in $R$-Parity-violating supersymmetric models. In some cases, especially when a higher-generation quark is involved and for the process $e p\to \tau X $, the ZEUS limits are the most stringent to date., Comment: 37 pages, 10 figures, Accepted by EPJC. References and 1 figure (Fig. 6) added

Published
2005

40. Multijet production in neutral current deep inelastic scattering at HERA and determination of alpha(s)

Author

S. CHEKANOV, M. DERRICK, J. H. LOIZIDES, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M. C. K. MATTINGLY, N. PAVEL, P. ANTONIOLI, G. BARI, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, F. CINDOLO, M. CORRADI, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, S. DE PASQUALE, A. PESCI, G. CARA ROMEO, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H. P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, A. STIFUTKIN, J. TANDLER, K. C. VOSS, M. WANG, D. S. BAILEY, N. H. BROOK, J. E. COLE, G. P. HEATH, T. NAMSOO, S. ROBINS, M. WING, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, J. Y. KIM, I. T. LIM, K. J. MA, M. Y. PAC, M. HELBICH, Y. NING, Z. REN, W. B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA BOLD, D. KISIELEWSKA, A. M. KOWAL, M. KOWAL, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, D. SZUBA, J. SZUBA, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, V. CHIOCHIA, D. DANNHEIM, G. DREWS, J. FOURLETOVA, U. FRICKE, A. GEISER, P. GOTTLICHER, O. GUTSCHE, T. HAAS, W. HAIN, S. HILLERT, C. HORN, B. KAHLE, U. KOTZ, H. KOWALSKI, G. KRAMBERGER, H. LABES, D. LELAS, H. LIM, B. LOHR, R. MANKEL, I. A. MELZER PELLMANN, C. N. NGUYEN, D. NOTZ, A. E. NUNCIO QUIROZ, A. POLINI, A. RAVAL, L. RURUA, U. SCHNEEKLOTH, U. STOSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, D. DOBUR, F. KARSTENS, N. N. VLASOV, M. BELL, P. J. BUSSEY, A. T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D. H. SAXON, I. O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHORNER SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, A.R. ZIEGLER, C. COLLINS TOOTH, C. FOUDAS, R. GONCALO, K. R. LONG, A. D. TAPPER, P. CLOTH, D. FILGES, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A. N. BARAKBAEV, E. G. BOOS, N. S. POKROVSKIY, B. O. ZHAUTYKOV, D. SON, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZALEZ, L. LABARGA, J. DEL PESO, E. TASSI, J. TERRON, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, S. GLIGA, J. LAINESSE, S. PADHI, D. G. STAIRS, R. WALSH, T. TSURUGAI, A. ANTONOV, P. DANILOV, B. A. DOLGOSHEIN, D. GLADKOV, V. SOSNOVTSEV, S. SUCHKOV, R. K. DEMENTIEV, P. F. ERMOLOV, I. I. KATKOV, L. A. KHEIN, I. A. KORZHAVINA, V. A. KUZMIN, B. B. LEVCHENKO, O. Y.U. LUKINA, A. S. PROSKURYAKOV, L. M. SHCHEGLOVA, S. A. ZOTKIN, I. ABT, C. BUTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, S. GRIJPINK, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, MONICA L. VAZQUEZ, L. WIGGERS, E. DE WOLF, N. BRUMMER, B. BYLSMA, L. S. DURKIN, T. Y. LING, A. M. COOPER SARKAR, A. COTTRELL, R. C. E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P. B. STRAUB, R. WALCZAK, A. BERTOLIN, R. BRUGNERA, R. CARLIN, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, A. PARENTI, M. POSOCCO, L. STANCO, M. TURCATO, E. A. HEAPHY, F. METLICA, B. Y. OH, J. J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, C. CORMACK, J. C. HART, N. A. MCCUBBIN, C. HEUSCH, I. H. PARK, H. ABRAMOWICZ, A. GABAREEN, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, T. FUSAYASU, S. KAGAWA, T. TAWARA, T. YAMASHITA, R. HAMATSU, T. HIROSE, M. INUZUKA, H. KAJI, S. KITAMURA, K. MATSUZAWA, M. COSTA, M. I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, T. KOOP, J. F. MARTIN, A. MIREA, J. M. BUTTERWORTH, R. HALL WILTON, T. W. JONES, M. S. LIGHTWOOD, M. R. SUTTON, C. TARGETT ADAMS, J. CIBOROWSKI, R. CIESIELSKI, P. LUZNIAK, R. J. NOWAK, J. M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A. F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. RIVELINE, A. EVERETT, L. K. GLADILIN, D. KCIRA, S. LAMMERS, L. LI, D. D. REEDER, M. ROSIN, P. RYAN, A. A. SAVIN, W. H. SMITH, S. DHAWAN, S. BHADRA, C. D. CATTERALL, S. FOURLETOV, G. HARTNER, S. MENARY, M. SOARES, J. STANDAGE, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, PALMONARI, FEDERICO, RINALDI, LORENZO, SARTORELLI, GABRIELLA, ZICHICHI, ANTONINO, S. CHEKANOV, M. DERRICK, J.H. LOIZIDES, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M.C.K. MATTINGLY, N. PAVEL, P. ANTONIOLI, G. BARI, M. BASILE, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, L. CIFARELLI, F. CINDOLO, A. CONTIN, M. CORRADI, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, F. PALMONARI, S. DE PASQUALE, A. PESCI, L. RINALDI, G. CARA ROMEO, G. SARTORELLI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H.-P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, A. STIFUTKIN, J. TANDLER, K.C. VOSS, M. WANG, D.S. BAILEY, N.H. BROOK, J.E. COLE, G.P. HEATH, T. NAMSOO, S. ROBINS, M. WING, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, J.Y. KIM, I.T. LIM, K.J. MA, M.Y. PAC, M. HELBICH, Y. NING, Z. REN, W.B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA-BOLD, D. KISIELEWSKA, A.M. KOWAL, M. KOWAL, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, D. SZUBA, J. SZUBA, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, V. CHIOCHIA, D. DANNHEIM, G. DREWS, J. FOURLETOVA, U. FRICKE, A. GEISER, P. GOTTLICHER, O. GUTSCHE, T. HAAS, W. HAIN, S. HILLERT, C. HORN, B. KAHLE, U. KOTZ, H. KOWALSKI, G. KRAMBERGER, H. LABES, D. LELAS, H. LIM, B. LOHR, R. MANKEL, I.-A. MELZER-PELLMANN, C.N. NGUYEN, D. NOTZ, A.E. NUNCIO-QUIROZ, A. POLINI, A. RAVAL, L. RURUA, U. SCHNEEKLOTH, U. STOSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, D. DOBUR, F. KARSTENS, N.N. VLASOV, M. BELL, P.J. BUSSEY, A.T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D.H. SAXON, I.O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHORNER-SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, AR. ZIEGLER, C. COLLINS-TOOTH, C. FOUDAS, R. GONCALO, K.R. LONG, A.D. TAPPER, P. CLOTH, D. FILGES, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A.N. BARAKBAEV, E.G. BOOS, N.S. POKROVSKIY, B.O. ZHAUTYKOV, D. SON, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZALEZ, L. LABARGA, J. DEL PESO, E. TASSI, J. TERRON, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, S. GLIGA, J. LAINESSE, S. PADHI, D.G. STAIRS, R. WALSH, T. TSURUGAI, A. ANTONOV, P. DANILOV, B.A. DOLGOSHEIN, D. GLADKOV, V. SOSNOVTSEV, S. SUCHKOV, R.K. DEMENTIEV, P.F. ERMOLOV, I.I. KATKOV, L.A. KHEIN, I.A. KORZHAVINA, V.A. KUZMIN, B.B. LEVCHENKO, O.YU. LUKINA, A.S. PROSKURYAKOV, L.M. SHCHEGLOVA, S.A. ZOTKIN, I. ABT, C. BUTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, S. GRIJPINK, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, MONICA L. VAZQUEZ, L. WIGGERS, E. DE WOLF, N. BRUMMER, B. BYLSMA, L.S. DURKIN, T.Y. LING, A.M. COOPER-SARKAR, A. COTTRELL, R.C.E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P.B. STRAUB, R. WALCZAK, A. BERTOLIN, R. BRUGNERA, R. CARLIN, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, A. PARENTI, M. POSOCCO, L. STANCO, M. TURCATO, E.A. HEAPHY, F. METLICA, B.Y. OH, J.J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, C. CORMACK, J.C. HART, N.A. MCCUBBIN, C. HEUSCH, I.H. PARK, H. ABRAMOWICZ, A. GABAREEN, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, T. FUSAYASU, S. KAGAWA, T. TAWARA, T. YAMASHITA, R. HAMATSU, T. HIROSE, M. INUZUKA, H. KAJI, S. KITAMURA, K. MATSUZAWA, M. COSTA, M.I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, T. KOOP, J.F. MARTIN, A. MIREA, J.M. BUTTERWORTH, R. HALL-WILTON, T.W. JONES, M.S. LIGHTWOOD, M.R. SUTTON, C. TARGETT-ADAMS, J. CIBOROWSKI, R. CIESIELSKI, P. LUZNIAK, R.J. NOWAK, J.M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A.F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. RIVELINE, A. EVERETT, L.K. GLADILIN, D. KCIRA, S. LAMMERS, L. LI, D.D. REEDER, M. ROSIN, P. RYAN, A.A. SAVIN, W.H. SMITH, S. DHAWAN, S. BHADRA, C.D. CATTERALL, S. FOURLETOV, G. HARTNER, S. MENARY, M. SOARES, J. STANDAGE, and UCL

Subjects
Particle physics, Physics and Astronomy (miscellaneous), HERA, FOS: Physical sciences, Jet (particle physics), 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), High Energy Physics, ZEUS Collaboration, 0103 physical sciences, 010306 general physics, Nuclear Experiment, Engineering (miscellaneous), Boson, Quantum chromodynamics, Physics, Range (particle radiation), ZEUS (particle detector), Neutral current, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Deep inelastic scattering, High Energy Physics::Experiment
Abstract

Multijet production rates in neutral current deep inelastic scattering have been measured in the range of exchanged boson virtualities 10 < Q2 < 5000 GeV2. The data were taken at the ep collider HERA with centre-of-mass energy sqrt(s) = 318 GeV using the ZEUS detector and correspond to an integrated luminosity of 82.2 pb-1. Jets were identified in the Breit frame using the k_T cluster algorithm in the longitudinally invariant inclusive mode. Measurements of differential dijet and trijet cross sections are presented as functions of jet transverse energy E_{T,B}{jet}, pseudorapidity eta_{LAB}{jet} and Q2 with E_{T,B}{jet} > 5 GeV and -1 < eta_{LAB}{jet} < 2.5. Next-to-leading-order QCD calculations describe the data well. The value of the strong coupling constant alpha_s(M_Z), determined from the ratio of the trijet to dijet cross sections, is alpha_s(M_Z) = 0.1179 pm 0.0013(stat.) {+0.0028}_{-0.0046}(exp.) {+0.0064}_{-0.0046}(th.), 22 pages, 5 figures

Published
2005

41. Measurement of charm fragmentation ratios and fractions in photoproduction at HERA

Author

S. CHEKANOV, M. DERRICK, J. H. LOIZIDES, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M. C. K. MATTINGLY, N. PAVEL, P. ANTONIOLI, G. BARI, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, F. CINDOLO, M. CORRADI, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, S. DE PASQUALE, A. PESCI, G. CARA ROMEO, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H. P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, A. STIFUTKIN, J. TANDLER, K. C. VOSS, M. WANG, D. S. BAILEY, N. H. BROOK, J. E. COLE, G. P. HEATH, T. NAMSOO, S. ROBINS, M. WING, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, J. Y. KIM, I. T. LIM, K. J. MA, M. Y. PAC, M. HELBICH, Y. NING, Z. REN, W. B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA BOLD, D. KISIELEWSKA, A. M. KOWAL, M. KOWAL, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, D. SZUBA, J. SZUBA, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, V. CHIOCHIA, D. DANNHEIM, G. DREWS, J. FOURLETOVA, U. FRICKE, A. GEISER, P. GOTTLICHER, O. GUTSCHE, T. HAAS, W. HAIN, S. HILLERT, C. HORN, B. KAHLE, U. KOTZ, H. KOWALSKI, G. KRAMBERGER, H. LABES, D. LELAS, H. LIM, B. LOHR, R. MANKEL, I. A. MELZER PELLMANN, C. N. NGUYEN, D. NOTZ, A. E. NUNCIO QUIROZ, A. POLINI, A. RAVAL, L. RURUA, U. SCHNEEKLOTH, U. STOSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, D. DOBUR, F. KARSTENS, N. N. VLASOV, M. BELL, P. J. BUSSEY, A. T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D. H. SAXON, I. O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHORNER SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, A.R. ZIEGLER, C. COLLINS TOOTH, C. FOUDAS, R. GONCALO, K. R. LONG, A. D. TAPPER, P. CLOTH, D. FILGES, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A. N. BARAKBAEV, E. G. BOOS, N. S. POKROVSKIY, B. O. ZHAUTYKOV, D. SON, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZALEZ, L. LABARGA, J. DEL PESO, E. TASSI, J. TERRON, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, S. GLIGA, J. LAINESSE, S. PADHI, D. G. STAIRS, R. WALSH, T. TSURUGAI, A. ANTONOV, P. DANILOV, B. A. DOLGOSHEIN, D. GLADKOV, V. SOSNOVTSEV, S. SUCHKOV, R. K. DEMENTIEV, P. F. ERMOLOV, I. I. KATKOV, L. A. KHEIN, I. A. KORZHAVINA, V. A. KUZMIN, B. B. LEVCHENKO, O. Y.U. LUKINA, A. S. PROSKURYAKOV, L. M. SHCHEGLOVA, S. A. ZOTKIN, I. ABT, C. BUTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, S. GRIJPINK, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, MONICA L. VAZQUEZ, L. WIGGERS, E. DE WOLF, N. BRUMMER, B. BYLSMA, L. S. DURKIN, T. Y. LING, A. M. COOPER SARKAR, A. COTTRELL, R. C. E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P. B. STRAUB, R. WALCZAK, A. BERTOLIN, R. BRUGNERA, R. CARLIN, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, A. PARENTI, M. POSOCCO, L. STANCO, M. TURCATO, E. A. HEAPHY, F. METLICA, B. Y. OH, J. J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, C. CORMACK, J. C. HART, N. A. MCCUBBIN, C. HEUSCH, I. H. PARK, H. ABRAMOWICZ, A. GABAREEN, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, T. FUSAYASU, S. KAGAWA, T. TAWARA, T. YAMASHITA, R. HAMATSU, T. HIROSE, M. INUZUKA, H. KAJI, S. KITAMURA, K. MATSUZAWA, M. COSTA, M. I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, T. KOOP, J. F. MARTIN, A. MIREA, J. M. BUTTERWORTH, R. HALL WILTON, T. W. JONES, M. S. LIGHTWOOD, M. R. SUTTON, C. TARGETT ADAMS, J. CIBOROWSKI, R. CIESIELSKI, P. LUZNIAK, R. J. NOWAK, J. M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A. F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. RIVELINE, A. EVERETT, L. K. GLADILIN, D. KCIRA, S. LAMMERS, L. LI, D. D. REEDER, M. ROSIN, P. RYAN, A. A. SAVIN, W. H. SMITH, S. DHAWAN, S. BHADRA, C. D. CATTERALL, S. FOURLETOV, G. HARTNER, S. MENARY, M. SOARES, J. STANDAGE, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, PALMONARI, FEDERICO, RINALDI, LORENZO, SARTORELLI, GABRIELLA, ZICHICHI, ANTONINO, UCL, S. CHEKANOV, M. DERRICK, J.H. LOIZIDES, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M.C.K. MATTINGLY, N. PAVEL, P. ANTONIOLI, G. BARI, M. BASILE, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, L. CIFARELLI, F. CINDOLO, A. CONTIN, M. CORRADI, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, F. PALMONARI, S. DE PASQUALE, A. PESCI, L. RINALDI, G. CARA ROMEO, G. SARTORELLI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H.-P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, A. STIFUTKIN, J. TANDLER, K.C. VOSS, M. WANG, D.S. BAILEY, N.H. BROOK, J.E. COLE, G.P. HEATH, T. NAMSOO, S. ROBINS, M. WING, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, J.Y. KIM, I.T. LIM, K.J. MA, M.Y. PAC, M. HELBICH, Y. NING, Z. REN, W.B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, L. ZAWIEJSKI, L. ADAMCZYK, T. BOLD, I. GRABOWSKA-BOLD, D. KISIELEWSKA, A.M. KOWAL, M. KOWAL, J. LUKASIK, M. PRZYBYCIEN, L. SUSZYCKI, D. SZUBA, J. SZUBA, A. KOTANSKI, W. SLOMINSKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, V. CHIOCHIA, D. DANNHEIM, G. DREWS, J. FOURLETOVA, U. FRICKE, A. GEISER, P. GOTTLICHER, O. GUTSCHE, T. HAAS, W. HAIN, S. HILLERT, C. HORN, B. KAHLE, U. KOTZ, H. KOWALSKI, G. KRAMBERGER, H. LABES, D. LELAS, H. LIM, B. LOHR, R. MANKEL, I.-A. MELZER-PELLMANN, C.N. NGUYEN, D. NOTZ, A.E. NUNCIO-QUIROZ, A. POLINI, A. RAVAL, L. RURUA, U. SCHNEEKLOTH, U. STOSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, D. DOBUR, F. KARSTENS, N.N. VLASOV, M. BELL, P.J. BUSSEY, A.T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D.H. SAXON, I.O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHORNER-SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, AR. ZIEGLER, C. COLLINS-TOOTH, C. FOUDAS, R. GONCALO, K.R. LONG, A.D. TAPPER, P. CLOTH, D. FILGES, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A.N. BARAKBAEV, E.G. BOOS, N.S. POKROVSKIY, B.O. ZHAUTYKOV, D. SON, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZALEZ, L. LABARGA, J. DEL PESO, E. TASSI, J. TERRON, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, S. GLIGA, J. LAINESSE, S. PADHI, D.G. STAIRS, R. WALSH, T. TSURUGAI, A. ANTONOV, P. DANILOV, B.A. DOLGOSHEIN, D. GLADKOV, V. SOSNOVTSEV, S. SUCHKOV, R.K. DEMENTIEV, P.F. ERMOLOV, I.I. KATKOV, L.A. KHEIN, I.A. KORZHAVINA, V.A. KUZMIN, B.B. LEVCHENKO, O.YU. LUKINA, A.S. PROSKURYAKOV, L.M. SHCHEGLOVA, S.A. ZOTKIN, I. ABT, C. BUTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, S. GRIJPINK, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, MONICA L. VAZQUEZ, L. WIGGERS, E. DE WOLF, N. BRUMMER, B. BYLSMA, L.S. DURKIN, T.Y. LING, A.M. COOPER-SARKAR, A. COTTRELL, R.C.E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P.B. STRAUB, R. WALCZAK, A. BERTOLIN, R. BRUGNERA, R. CARLIN, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, A. PARENTI, M. POSOCCO, L. STANCO, M. TURCATO, E.A. HEAPHY, F. METLICA, B.Y. OH, J.J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, C. CORMACK, J.C. HART, N.A. MCCUBBIN, C. HEUSCH, I.H. PARK, H. ABRAMOWICZ, A. GABAREEN, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, T. FUSAYASU, S. KAGAWA, T. TAWARA, T. YAMASHITA, R. HAMATSU, T. HIROSE, M. INUZUKA, H. KAJI, S. KITAMURA, K. MATSUZAWA, M. COSTA, M.I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, T. KOOP, J.F. MARTIN, A. MIREA, J.M. BUTTERWORTH, R. HALL-WILTON, T.W. JONES, M.S. LIGHTWOOD, M.R. SUTTON, C. TARGETT-ADAMS, J. CIBOROWSKI, R. CIESIELSKI, P. LUZNIAK, R.J. NOWAK, J.M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. UKLEJA, J. UKLEJA, A.F. ZARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. RIVELINE, A. EVERETT, L.K. GLADILIN, D. KCIRA, S. LAMMERS, L. LI, D.D. REEDER, M. ROSIN, P. RYAN, A.A. SAVIN, W.H. SMITH, S. DHAWAN, S. BHADRA, C.D. CATTERALL, S. FOURLETOV, G. HARTNER, S. MENARY, M. SOARES, and J. STANDAGE

Subjects
Particle physics, Physics and Astronomy (miscellaneous), LUND MONTE-CARLO, HERA, FOS: Physical sciences, High Energy Physics, ZEUS Collaboration, DEEP INELASTIC-SCATTERING, CENTRAL TRACKING DETECTOR, ZEUS BARREL CALORIMETER, JET FRAGMENTATION, HADRON PRODUCTION, cross sections, EP-COLLISIONS, PARTON DISTRIBUTIONS, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, Charm (quantum number), Nuclear Experiment, 010306 general physics, Engineering (miscellaneous), Physics, ZEUS (particle detector), 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Fragmentation (computing), Deep inelastic scattering, High Energy Physics::Experiment
Abstract

The production of D^*+, D^0, D^+, D_s^+ and Lambda_c^+ charm hadrons and their antiparticles in ep scattering at HERA was measured with the ZEUS detector using an integrated luminosity of 79 pb^-1. The measurement has been performed in the photoproduction regime with the exchanged-photon virtuality Q^2 < 1 GeV^2 and for photon-proton centre-of-mass energies in the range 130 < W < 300 GeV. The charm hadrons were reconstructed in the range of transverse momentum p_T(D, Lambda_c) > 3.8 GeV and pseudorapidity |eta(D, Lambda_c)| < 1.6. The production cross sections were used to determine the ratio of neutral and charged D-meson production rates, R_u/d, the strangeness-suppression factor, gamma_s, and the fraction of charged D mesons produced in a vector state, P_v^d. The measured R_u/d and gamma_s values agree with those obtained in deep inelastic scattering and in e^+e^- annihilations. The measured P_v^d value is smaller than, but consistent with, the previous measurements. The fractions of c quarks hadronising as a particular charm hadron, f(c -> D, Lambda_c), were derived in the given kinematic range. The measured open-charm fragmentation fractions are consistent with previous results, although the measured f(c -> D^*+) is smaller and f(c -> Lambda_c^+) is larger than those obtained in e^+e^- annihilations. These results generally support the hypothesis that fragmentation proceeds independently of the hard sub-process., 29 pages, 5 figures, 6 tables; minor text revisions

Published
2005

42. Bose-Einstein correlations in one and two dimensions in deep inelastic scattering

Author

S. CHEKANOV, M. DERRICK, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M. C. K. MATTINGLY, N. PAVEL, A. G. YAGÜES MOLINA, P. ANTONIOLI, G. BARI, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, G. CARA ROMEO, F. CINDOLO, M. CORRADI, S. DE PASQUALE, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, A. PESCI, A. POLINI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H. P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, K. C. VOSS, M. WANG, M. WLASENKO, D. S. BAILEY, N. H. BROOK, J. E. COLE, G. P. HEATH, T. NAMSOO, S. ROBINS, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, E. TASSI, J. Y. KIM, K. J. MA, M. HELBICH, Y. NING, Z. REN, W. B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, D. SZUBA, L. ZAWIEJSKI, L. ADAMCZYK, T. BO_D, I. GRABOWSKA BO_D, D. KISIELEWSKA, A. M. KOWAL, J. _UKASIK, M. PRZYBYCIE, L. SUSZYCKI, J. SZUBA, A. KOTA_SKI, W. S_OMI_SKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, D. G. CASSEL, G. DREWS, J. FOURLETOVA, A. GEISER, D. GLADKOV, F. GOEBEL, P. GÖTTLICHER, R. GRACIANI DIAZ, O. GUTSCHE, T. HAAS, W. HAIN, C. HORN, B. KAHLE, M. KASEMANN, U. KÖTZ, H. KOWALSKI, G. KRAMBERGER, D. LELAS, H. LIM, B. LÖHR, R. MANKEL, M. MARTINEZ, I. A. MELZER PELLMANN, C. N. NGUYEN, D. NOTZ, A. E. NUNCIO QUIROZ, A. RAVAL, R. SANTAMARTA, U. SCHNEEKLOTH, U. STÖSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, F. KARSTENS, D. DOBUR, N. N. VLASOV, P. J. BUSSEY, A. T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D. H. SAXON, I. O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHÖRNER SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, A.R. ZIEGLER, C. COLLINS TOOTH, C. FOUDAS, C. FRY, R. GONÇALO, K. R. LONG, A. D. TAPPER, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A. N. BARAKBAEV, E. G. BOOS, N. S. POKROVSKIY, B. O. ZHAUTYKOV, D. SON, J. DE FAVEREAU, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZÁLEZ, M. JIMENEZ, L. LABARGA, J. DEL PESO, J. TERRÓN, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, C. LIU, S. PADHI, M. PLAMONDON, D. G. STAIRS, R. WALSH, C. ZHOU, T. TSURUGAI, A. ANTONOV, P. DANILOV, B. A. DOLGOSHEIN, V. SOSNOVTSEV, A. STIFUTKIN, S. SUCHKOV, R. K. DEMENTIEV, P. F. ERMOLOV, L. K. GLADILIN, I. I. KATKOV, L. A. KHEIN, I. A. KORZHAVINA, V. A. KUZMIN, B. B. LEVCHENKO, O. Y.U. LUKINA, A. S. PROSKURYAKOV, L. M. SHCHEGLOVA, D. S. ZOTKIN, S. A. ZOTKIN, I. ABT, C. BÜTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, G. GRIGORESCU, S. GRIJPINK, A. KERAMIDAS, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, M. VÁZQUEZ, L. WIGGERS, E. DE WOLF, N. BRÜMMER, B. BYLSMA, L. S. DURKIN, T. Y. LING, P. D. ALLFREY, M. A. BELL, A. M. COOPER SARKAR, A. COTTRELL, R. C. E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P. B. STRAUB, R. WALCZAK, P. BELLAN, A. BERTOLIN, R. BRUGNERA, R. CARLIN, R. CIESIELSKI, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, L. STANCO, M. TURCATO, E. A. HEAPHY, F. METLICA, B. Y. OH, J. J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, J. C. HART, H. ABRAMOWICZ, A. GABAREEN, M. GROYS, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, S. KAGAWA, T. TAWARA, R. HAMATSU, H. KAJI, S. KITAMURA, K. MATSUZAWA, O. OTA, Y. D. RI, M. COSTA, M. I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, S. FOURLETOV, T. KOOP, J. F. MARTIN, A. MIREA, J. M. BUTTERWORTH, R. HALL WILTON, T. W. JONES, J. H. LOIZIDES, M. R. SUTTON, C. TARGETT ADAMS, M. WING, J. CIBOROWSKI, P. KULINSKI, P. _U˝NIAK, J. MALKA, R. J. NOWAK, J. M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. TYSZKIEWICZ, A. UKLEJA, J. UKLEJA, A. F. ˚ARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. S. LIGHTWOOD, A. EVERETT, D. KÇIRA, S. LAMMERS, L. LI, D. D. REEDER, M. ROSIN, P. RYAN, A. A. SAVIN, W. H. SMITH, S. DHAWAN, S. BHADRA, C. D. CATTERALL, Y. CUI, G. HARTNER, S. MENARY, U. NOOR, M. SOARES, J. STANDAGE, J. WHYTE, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, PALMONARI, FEDERICO, RINALDI, LORENZO, SARTORELLI, GABRIELLA, ZICHICHI, ANTONINO, Zeus (IHEF, IoP, FNWI), UCL, S. CHEKANOV, M. DERRICK, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M.C.K. MATTINGLY, N. PAVEL, A.G. YAGÜES MOLINA, P. ANTONIOLI, G. BARI, M. BASILE, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, G. CARA ROMEO, L. CIFARELLI, F. CINDOLO, A. CONTIN, M. CORRADI, S. DE PASQUALE, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, F. PALMONARI, A. PESCI, A. POLINI, L. RINALDI, G. SARTORELLI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H.-P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, K.C. VOSS, M. WANG, M. WLASENKO, D.S. BAILEY, N.H. BROOK, J.E. COLE, G.P. HEATH, T. NAMSOO, S. ROBINS, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, E. TASSI, J.Y. KIM, K.J. MA, M. HELBICH, Y. NING, Z. REN, W.B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, D. SZUBA, L. ZAWIEJSKI, L. ADAMCZYK, T. BO_D, I. GRABOWSKA-BO_D, D. KISIELEWSKA, A.M. KOWAL, J. _UKASIK, M. PRZYBYCIE, L. SUSZYCKI, J. SZUBA, A. KOTA_SKI, W. S_OMI_SKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, D.G. CASSEL, G. DREWS, J. FOURLETOVA, A. GEISER, D. GLADKOV, F. GOEBEL, P. GÖTTLICHER, R. GRACIANI DIAZ, O. GUTSCHE, T. HAAS, W. HAIN, C. HORN, B. KAHLE, M. KASEMANN, U. KÖTZ, H. KOWALSKI, G. KRAMBERGER, D. LELAS, H. LIM, B. LÖHR, R. MANKEL, M. MARTINEZ, I.-A. MELZER-PELLMANN, C.N. NGUYEN, D. NOTZ, A.E. NUNCIO-QUIROZ, A. RAVAL, R. SANTAMARTA, U. SCHNEEKLOTH, U. STÖSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P.G. PELFER, A. BAMBERGER, A. BENEN, F. KARSTENS, D. DOBUR, N.N. VLASOV, P.J. BUSSEY, A.T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D.H. SAXON, I.O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHÖRNER-SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, AR. ZIEGLER, C. COLLINS-TOOTH, C. FOUDAS, C. FRY, R. GONÇALO, K.R. LONG, A.D. TAPPER, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A.N. BARAKBAEV, E.G. BOOS, N.S. POKROVSKIY, B.O. ZHAUTYKOV, D. SON, J. DE FAVEREAU, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZÁLEZ, M. JIMENEZ, L. LABARGA, J. DEL PESO, J. TERRÓN, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, C. LIU, S. PADHI, M. PLAMONDON, D.G. STAIRS, R. WALSH, C. ZHOU, T. TSURUGAI, A. ANTONOV, P. DANILOV, B.A. DOLGOSHEIN, V. SOSNOVTSEV, A. STIFUTKIN, S. SUCHKOV, R.K. DEMENTIEV, P.F. ERMOLOV, L.K. GLADILIN, I.I. KATKOV, L.A. KHEIN, I.A. KORZHAVINA, V.A. KUZMIN, B.B. LEVCHENKO, O.YU. LUKINA, A.S. PROSKURYAKOV, L.M. SHCHEGLOVA, D.S. ZOTKIN, S.A. ZOTKIN, I. ABT, C. BÜTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, G. GRIGORESCU, S. GRIJPINK, A. KERAMIDAS, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, M. VÁZQUEZ, L. WIGGERS, E. DE WOLF, N. BRÜMMER, B. BYLSMA, L.S. DURKIN, T.Y. LING, P.D. ALLFREY, M.A. BELL, A.M. COOPER-SARKAR, A. COTTRELL, R.C.E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P.B. STRAUB, R. WALCZAK, P. BELLAN, A. BERTOLIN, R. BRUGNERA, R. CARLIN, R. CIESIELSKI, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, L. STANCO, M. TURCATO, E.A. HEAPHY, F. METLICA, B.Y. OH, J.J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, J.C. HART, H. ABRAMOWICZ, A. GABAREEN, M. GROYS, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, S. KAGAWA, T. TAWARA, R. HAMATSU, H. KAJI, S. KITAMURA, K. MATSUZAWA, O. OTA, Y.D. RI, M. COSTA, M.I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, S. FOURLETOV, T. KOOP, J.F. MARTIN, A. MIREA, J.M. BUTTERWORTH, R. HALL-WILTON, T.W. JONES, J.H. LOIZIDES, M.R. SUTTON, C. TARGETT-ADAMS, M. WING, J. CIBOROWSKI, P. KULINSKI, P. _U˝NIAK, J. MALKA, R.J. NOWAK, J.M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. TYSZKIEWICZ, A. UKLEJA, J. UKLEJA, A.F. ˚ARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M.S. LIGHTWOOD, A. EVERETT, D. KÇIRA, S. LAMMERS, L. LI, D.D. REEDER, M. ROSIN, P. RYAN, A.A. SAVIN, W.H. SMITH, S. DHAWAN, S. BHADRA, C.D. CATTERALL, Y. CUI, G. HARTNER, S. MENARY, U. NOOR, M. SOARES, J. STANDAGE, and J. WHYTE

Subjects
Particle physics, Nuclear and High Energy Physics, Photon, HERA, FOS: Physical sciences, TRACKING DETECTOR, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Particle tracking detectors, 0103 physical sciences, HADRONIC Z(0) DECAYS, ZEUS BARREL CALORIMETER, REAR CALORIMETER, BREIT FRAME, LOW Q(2), Bibliography, High Energy Physics, 010306 general physics, QC, ZEUS Collaboration, Interferometry, MULTIPLICITY, Physics, Neutral current, 010308 nuclear & particles physics, Scattering, Bose–Einstein correlations, Deep inelastic scattering, Transverse plane, High Energy Physics::Experiment
Abstract

Bose-Einstein correlations in one and two dimensions have been studied in deep inelastic EP scattering events measured with the ZEUS detector at HERA using an integrated luminosity of 121 pb-1. The correlations are independent of the virtuality of the exchanged photon, Q2, in the range 0.1100 GeV2. The two-dimensional shape of the particle-production source was investigated, and a significant difference between the transverse and the longitudinal dimensions of the source is observed.This difference also shows no Q2 dependence.The results demonstrate that Bose-Einstein interference, and hence the size of the particle-production source, is insensitive to the hard subprocess., Comment: 17 pages, 4 EPS figures, 2 tables

Published
2004

43. Evidence for a narrow baryonic state decaying to K0s-(anti)proton in deep inelastic scattering at HERA

Author

S. CHEKANOV, M. DERRICK, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M. C. K. MATTINGLY, N. PAVEL, A. G. YAGÜES MOLINA, P. ANTONIOLI, G. BARI, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, G. CARA ROMEO, F. CINDOLO, M. CORRADI, S. DE PASQUALE, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, A. PESCI, A. POLINI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H. P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, K. C. VOSS, M. WANG, M. WLASENKO, D. S. BAILEY, N. H. BROOK, J. E. COLE, G. P. HEATH, T. NAMSOO, S. ROBINS, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, E. TASSI, J. Y. KIM, K. J. MA, M. HELBICH, Y. NING, Z. REN, W. B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, D. SZUBA, L. ZAWIEJSKI, L. ADAMCZYK, T. BO_D, I. GRABOWSKA BO_D, D. KISIELEWSKA, A. M. KOWAL, J. _UKASIK, M. PRZYBYCIE, L. SUSZYCKI, J. SZUBA, A. KOTA_SKI, W. S_OMI_SKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, D. G. CASSEL, G. DREWS, J. FOURLETOVA, A. GEISER, D. GLADKOV, F. GOEBEL, P. GÖTTLICHER, R. GRACIANI DIAZ, O. GUTSCHE, T. HAAS, W. HAIN, C. HORN, B. KAHLE, M. KASEMANN, U. KÖTZ, H. KOWALSKI, G. KRAMBERGER, D. LELAS, H. LIM, B. LÖHR, R. MANKEL, M. MARTINEZ, I. A. MELZER PELLMANN, C. N. NGUYEN, D. NOTZ, A. E. NUNCIO QUIROZ, A. RAVAL, R. SANTAMARTA, U. SCHNEEKLOTH, U. STÖSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P. G. PELFER, A. BAMBERGER, A. BENEN, F. KARSTENS, D. DOBUR, N. N. VLASOV, P. J. BUSSEY, A. T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D. H. SAXON, I. O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHÖRNER SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, A.R. ZIEGLER, C. COLLINS TOOTH, C. FOUDAS, C. FRY, R. GONÇALO, K. R. LONG, A. D. TAPPER, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A. N. BARAKBAEV, E. G. BOOS, N. S. POKROVSKIY, B. O. ZHAUTYKOV, D. SON, J. DE FAVEREAU, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZÁLEZ, M. JIMENEZ, L. LABARGA, J. DEL PESO, J. TERRÓN, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, C. LIU, S. PADHI, M. PLAMONDON, D. G. STAIRS, R. WALSH, C. ZHOU, T. TSURUGAI, A. ANTONOV, P. DANILOV, B. A. DOLGOSHEIN, V. SOSNOVTSEV, A. STIFUTKIN, S. SUCHKOV, R. K. DEMENTIEV, P. F. ERMOLOV, L. K. GLADILIN, I. I. KATKOV, L. A. KHEIN, I. A. KORZHAVINA, V. A. KUZMIN, B. B. LEVCHENKO, O. Y.U. LUKINA, A. S. PROSKURYAKOV, L. M. SHCHEGLOVA, D. S. ZOTKIN, S. A. ZOTKIN, I. ABT, C. BÜTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, G. GRIGORESCU, S. GRIJPINK, A. KERAMIDAS, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, M. VÁZQUEZ, L. WIGGERS, E. DE WOLF, N. BRÜMMER, B. BYLSMA, L. S. DURKIN, T. Y. LING, P. D. ALLFREY, M. A. BELL, A. M. COOPER SARKAR, A. COTTRELL, R. C. E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P. B. STRAUB, R. WALCZAK, P. BELLAN, A. BERTOLIN, R. BRUGNERA, R. CARLIN, R. CIESIELSKI, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, L. STANCO, M. TURCATO, E. A. HEAPHY, F. METLICA, B. Y. OH, J. J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, J. C. HART, H. ABRAMOWICZ, A. GABAREEN, M. GROYS, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, S. KAGAWA, T. TAWARA, R. HAMATSU, H. KAJI, S. KITAMURA, K. MATSUZAWA, O. OTA, Y. D. RI, M. COSTA, M. I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, S. FOURLETOV, T. KOOP, J. F. MARTIN, A. MIREA, J. M. BUTTERWORTH, R. HALL WILTON, T. W. JONES, J. H. LOIZIDES, M. R. SUTTON, C. TARGETT ADAMS, M. WING, J. CIBOROWSKI, P. KULINSKI, P. _U, 733, NIAK, J. MALKA, R. J. NOWAK, J. M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. TYSZKIEWICZ, A. UKLEJA, J. UKLEJA, A. F. , #730, ARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M. S. LIGHTWOOD, A. EVERETT, D. KÇIRA, S. LAMMERS, L. LI, D. D. REEDER, M. ROSIN, P. RYAN, A. A. SAVIN, W. H. SMITH, S. DHAWAN, S. BHADRA, C. D. CATTERALL, Y. CUI, G. HARTNER, S. MENARY, U. NOOR, M. SOARES, J. STANDAGE, J. WHYTE, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, PALMONARI, FEDERICO, RINALDI, LORENZO, SARTORELLI, GABRIELLA, ZICHICHI, ANTONINO, S. CHEKANOV, M. DERRICK, S. MAGILL, S. MIGLIORANZI, B. MUSGRAVE, J. REPOND, R. YOSHIDA, M.C.K. MATTINGLY, N. PAVEL, A.G. YAGÜES MOLINA, P. ANTONIOLI, G. BARI, M. BASILE, L. BELLAGAMBA, D. BOSCHERINI, A. BRUNI, G. BRUNI, G. CARA ROMEO, L. CIFARELLI, F. CINDOLO, A. CONTIN, M. CORRADI, S. DE PASQUALE, P. GIUSTI, G. IACOBUCCI, A. MARGOTTI, A. MONTANARI, R. NANIA, F. PALMONARI, A. PESCI, A. POLINI, L. RINALDI, G. SARTORELLI, A. ZICHICHI, G. AGHUZUMTSYAN, D. BARTSCH, I. BROCK, S. GOERS, H. HARTMANN, E. HILGER, P. IRRGANG, H.-P. JAKOB, O. KIND, U. MEYER, E. PAUL, J. RAUTENBERG, R. RENNER, K.C. VOSS, M. WANG, M. WLASENKO, D.S. BAILEY, N.H. BROOK, J.E. COLE, G.P. HEATH, T. NAMSOO, S. ROBINS, M. CAPUA, A. MASTROBERARDINO, M. SCHIOPPA, G. SUSINNO, E. TASSI, J.Y. KIM, K.J. MA, M. HELBICH, Y. NING, Z. REN, W.B. SCHMIDKE, F. SCIULLI, J. CHWASTOWSKI, A. ESKREYS, J. FIGIEL, A. GALAS, K. OLKIEWICZ, P. STOPA, D. SZUBA, L. ZAWIEJSKI, L. ADAMCZYK, T. BO_D, I. GRABOWSKA-BO_D, D. KISIELEWSKA, A.M. KOWAL, J. _UKASIK, M. PRZYBYCIE_, L. SUSZYCKI, J. SZUBA, A. KOTA_SKI, W. S_OMI_SKI, V. ADLER, U. BEHRENS, I. BLOCH, K. BORRAS, D.G. CASSEL, G. DREWS, J. FOURLETOVA, A. GEISER, D. GLADKOV, F. GOEBEL, P. GÖTTLICHER, R. GRACIANI DIAZ, O. GUTSCHE, T. HAAS, W. HAIN, C. HORN, B. KAHLE, M. KASEMANN, U. KÖTZ, H. KOWALSKI, G. KRAMBERGER, D. LELAS, H. LIM, B. LÖHR, R. MANKEL, M. MARTINEZ, I.-A. MELZER-PELLMANN, C.N. NGUYEN, D. NOTZ, A.E. NUNCIO-QUIROZ, A. RAVAL, R. SANTAMARTA, U. SCHNEEKLOTH, U. STÖSSLEIN, G. WOLF, C. YOUNGMAN, W. ZEUNER, S. SCHLENSTEDT, G. BARBAGLI, E. GALLO, C. GENTA, P.G. PELFER, A. BAMBERGER, A. BENEN, F. KARSTENS, D. DOBUR, N.N. VLASOV, P.J. BUSSEY, A.T. DOYLE, J. FERRANDO, J. HAMILTON, S. HANLON, D.H. SAXON, I.O. SKILLICORN, I. GIALAS, T. CARLI, T. GOSAU, U. HOLM, N. KRUMNACK, E. LOHRMANN, M. MILITE, H. SALEHI, P. SCHLEPER, T. SCHÖRNER-SADENIUS, S. STONJEK, K. WICHMANN, K. WICK, A. ZIEGLER, AR. ZIEGLER, C. COLLINS-TOOTH, C. FOUDAS, C. FRY, R. GONÇALO, K.R. LONG, A.D. TAPPER, M. KATAOKA, K. NAGANO, K. TOKUSHUKU, S. YAMADA, Y. YAMAZAKI, A.N. BARAKBAEV, E.G. BOOS, N.S. POKROVSKIY, B.O. ZHAUTYKOV, D. SON, J. DE FAVEREAU, K. PIOTRZKOWSKI, F. BARREIRO, C. GLASMAN, O. GONZÁLEZ, M. JIMENEZ, L. LABARGA, J. DEL PESO, J. TERRÓN, M. ZAMBRANA, M. BARBI, F. CORRIVEAU, C. LIU, S. PADHI, M. PLAMONDON, D.G. STAIRS, R. WALSH, C. ZHOU, T. TSURUGAI, A. ANTONOV, P. DANILOV, B.A. DOLGOSHEIN, V. SOSNOVTSEV, A. STIFUTKIN, S. SUCHKOV, R.K. DEMENTIEV, P.F. ERMOLOV, L.K. GLADILIN, I.I. KATKOV, L.A. KHEIN, I.A. KORZHAVINA, V.A. KUZMIN, B.B. LEVCHENKO, O.YU. LUKINA, A.S. PROSKURYAKOV, L.M. SHCHEGLOVA, D.S. ZOTKIN, S.A. ZOTKIN, I. ABT, C. BÜTTNER, A. CALDWELL, X. LIU, J. SUTIAK, N. COPPOLA, G. GRIGORESCU, S. GRIJPINK, A. KERAMIDAS, E. KOFFEMAN, P. KOOIJMAN, E. MADDOX, A. PELLEGRINO, S. SCHAGEN, H. TIECKE, M. VÁZQUEZ, L. WIGGERS, E. DE WOLF, N. BRÜMMER, B. BYLSMA, L.S. DURKIN, T.Y. LING, P.D. ALLFREY, M.A. BELL, A.M. COOPER-SARKAR, A. COTTRELL, R.C.E. DEVENISH, B. FOSTER, G. GRZELAK, C. GWENLAN, T. KOHNO, S. PATEL, P.B. STRAUB, R. WALCZAK, P. BELLAN, A. BERTOLIN, R. BRUGNERA, R. CARLIN, R. CIESIELSKI, F. DAL CORSO, S. DUSINI, A. GARFAGNINI, S. LIMENTANI, A. LONGHIN, L. STANCO, M. TURCATO, E.A. HEAPHY, F. METLICA, B.Y. OH, J.J. WHITMORE, Y. IGA, G. D'AGOSTINI, G. MARINI, A. NIGRO, J.C. HART, H. ABRAMOWICZ, A. GABAREEN, M. GROYS, S. KANANOV, A. KREISEL, A. LEVY, M. KUZE, S. KAGAWA, T. TAWARA, R. HAMATSU, H. KAJI, S. KITAMURA, K. MATSUZAWA, O. OTA, Y.D. RI, M. COSTA, M.I. FERRERO, V. MONACO, R. SACCHI, A. SOLANO, M. ARNEODO, M. RUSPA, S. FOURLETOV, T. KOOP, J.F. MARTIN, A. MIREA, J.M. BUTTERWORTH, R. HALL-WILTON, T.W. JONES, J.H. LOIZIDES, M.R. SUTTON, C. TARGETT-ADAMS, M. WING, J. CIBOROWSKI, P. KULINSKI, P. _U&#733, NIAK, J. MALKA, R.J. NOWAK, J.M. PAWLAK, J. SZTUK, T. TYMIENIECKA, A. TYSZKIEWICZ, A. UKLEJA, J. UKLEJA, A.F. &#730, and ARNECKI, M. ADAMUS, P. PLUCINSKI, Y. EISENBERG, D. HOCHMAN, U. KARSHON, M.S. LIGHTWOOD, A. EVERETT, D. KÇIRA, S. LAMMERS, L. LI, D.D. REEDER, M. ROSIN, P. RYAN, A.A. SAVIN, W.H. SMITH, S. DHAWAN, S. BHADRA, C.D. CATTERALL, Y. CUI, G. HARTNER, S. MENARY, U. NOOR, M. SOARES, J. STANDAGE, J. WHYTE

Subjects
High Energy Physics::Experiment, Nuclear Experiment
Abstract

A resonance search has been made in the K0s p and K0s pbar invariant-mass spectrum measured with the ZEUS detector at HERA using an integrated luminosity of 121 pb-1. The search was performed in the central rapidity region of inclusive deep inelastic scattering at an ep centre-of-mass energy of 300-318 GeV for exchanged photon virtuality, Q2, above 1 GeV2. Recent results from fixed-target experiments give evidence for a narrow baryon resonance decaying to K+ n and K0s p, interpreted as a pentaquark. The results presented here support the existence of such state, with a mass of 1521.5+/-1.5(stat.)^{+2.8}_{-1.7}(syst.) MeV and a Gaussian width consistent with the experimental resolution of 2 MeV. The signal is visible at high Q2 and, for Q2>20 GeV2, contains 221+/-48 events. The probability of a similar signal anywhere in the range 1500-1560 MeV arising from fluctuations of the background is below 6x10^{-5}.

Published
2004

44. Proton equilibria in the minor groove of DNA

Author

G.R. Pack, S. Hanlon, and Lid B. Wong

Subjects
Models, Molecular, Circular dichroism, Stereochemistry, Guanine, Carboxylic acid, Glycine, Biophysics, Adduct, chemistry.chemical_compound, DNA Adducts, Deprotonation, Amino Acids, Caproates, gamma-Aminobutyric Acid, chemistry.chemical_classification, Alanine, Circular Dichroism, DNA, Models, Theoretical, Amino acid, Solvent, Crystallography, Kinetics, chemistry, Nucleic Acid Conformation, Thermodynamics, Research Article
Abstract

Poisson-Boltzmann calculations by Pack and co-workers suggest the presence of regions of increased hydrogen ion density in the grooves of DNA. As an experimental test of this prediction, we have attached proton-sensitive probes, with variable linker lengths, to random-sequence DNA at G sites in the minor groove. The amino groups of beta-alanine, gamma-aminobutyric acid (GABA), and epsilon-aminocaproic acid have been coupled at pH 5, via a formaldehyde link, to the exocyclic amino group of guanine, utilizing a reaction that has been extensively investigated by Hanlon and co-workers. The resulting adducts at pH 5 retained duplex B form but exhibited typical circular dichroism (CD) changes previously shown to be correlated with the presence of a net positive charge in the minor groove. Increases in the solvent pH reversed the CD spectral changes in a manner suggesting deprotonation of the carboxylic acid group of the adduct. These data were used to calculate an apparent pK(a) for the COOH. The pK(a) was increased by 2.4 units for beta-alanine, by 1.7 units for GABA, and by 1.5 units for epsilon-amino caproic acid, relative to their values in the free amino acid. This agrees well with Poisson-Boltzmann calculations and the energy minimization of the structures of the adducts that place the carboxyl groups in acidic domains whose hydrogen ion density is approximately 2 orders of magnitude greater than that of bulk solvent.

Published
1997
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45. Impact of co-digestion on existing salt and nutrient mass balances for a full-scale dairy energy project

Author

Chelsea Spier, Jeremy K. Domen, Jeremy S. Hanlon, Mary Kay Camarillo, and William T. Stringfellow

Subjects
Environmental Engineering, Silage, Nitrogen, Biomass, Industrial Waste, Management, Monitoring, Policy and Law, Wastewater, Wine grape, Nutrient, Chlorides, Waste Management, Bioenergy, Animals, Vitis, Anaerobiosis, Renewable Energy, Waste Management and Disposal, Waste management, Chemistry, Pomace, food and beverages, Phosphorus, General Medicine, Manure, Carbon, Anaerobic digestion, Dairying, Biofuels, Potassium, Salts, Methane, Sulfur
Abstract

Anaerobic digestion of manure and other agricultural waste streams with subsequent energy production can result in more sustainable dairy operations; however, importation of digester feedstocks onto dairy farms alters previously established carbon, nutrient, and salinity mass balances. Salt and nutrient mass balance must be maintained to avoid groundwater contamination and salination. To better understand salt and nutrient contributions of imported methane-producing substrates, a mass balance for a full-scale dairy biomass energy project was developed for solids, carbon, nitrogen, sulfur, phosphorus, chloride, and potassium. Digester feedstocks, consisting of thickened manure flush-water slurry, screened manure solids, sudan grass silage, and feed-waste, were tracked separately in the mass balance. The error in mass balance closure for most elements was less than 5%. Manure contributed 69.2% of influent dry matter while contributing 77.7% of nitrogen, 90.9% of sulfur, and 73.4% of phosphorus. Sudan grass silage contributed high quantities of chloride and potassium, 33.3% and 43.4%, respectively, relative to the dry matter contribution of 22.3%. Five potential off-site co-digestates (egg waste, grape pomace, milk waste, pasta waste, whey wastewater) were evaluated for anaerobic digestion based on salt and nutrient content in addition to bio-methane potential. Egg waste and wine grape pomace appeared the most promising co-digestates due to their high methane potentials relative to bulk volume. Increasing power production from the current rate of 369 kW to the design value of 710 kW would require co-digestion with either 26800 L d(-1) egg waste or 60900 kg d(-1) grape pomace. However, importation of egg waste would more than double nitrogen loading, resulting in an increase of 172% above the baseline while co-digestion with grape pomace would increase potassium by 279%. Careful selection of imported co-digestates and management of digester effluent is required to manage salt and nutrient mass loadings and reduce groundwater impacts.

Published
2013

46. Weight bias among UK trainee dietitians, doctors, nurses and nutritionists

Author

L. El-Redy, Judy A. Swift, Cris Glazebrook, S. Hanlon, and Rebecca M. Puhl

Subjects
Gerontology, Adult, Male, Students, Medical, Demographics, Adolescent, Attitude of Health Personnel, Psychological intervention, Medicine (miscellaneous), Nurses, Overweight, Fat phobia, Body Mass Index, Young Adult, Professional Competence, Physicians, Surveys and Questionnaires, medicine, Humans, Nutritionists, Obesity, Students, Nutrition and Dietetics, business.industry, Multilevel model, Body Weight, medicine.disease, United Kingdom, Adipose Tissue, Scale (social sciences), Female, Perception, Students, Nursing, Self Report, medicine.symptom, business, Body mass index, Prejudice
Abstract

Background Trainee dietitians, nutritionists, nurses and doctors will direct the future of obesity treatment and prevention. To do so effectively, they must be willing and able to engage empathically with overweight and obese people. The present study aimed to assess weight bias among UK trainee healthcare professionals and to investigate the factors predicting weight bias, both static and potentially modifiable. Methods A self-completed questionnaire collected data on demographics, weight and height, the Fat Phobia Scale (F-scale), and the Beliefs about Obese People (BOAP) scale from 1130 students. Results Overall, participants demonstrated significant levels of fat phobia [F-scale score mean (SD) = 3.8 (0.5)]. Only 1.4% of participants could be said to have expressed ‘positive or neutral attitudes’ (i.e. achieved a F-scale score ≤ 2.5). Hierarchical multiple regression revealed that lower fat phobia (as measured by the F-scale) was uniquely predicted by a higher self-reported body mass index, being on the Nursing BSc course and a stronger perception that obesity is not under a person's control (as measured by the BOAP scale). Conclusions There are unacceptable levels of weight bias among UK students training to become nurses, doctors, nutritionists and dietitians. The results of the present study suggest that a promising approach for future interventions would be the provision of balanced education about the controllability of obesity, focusing upon genetic and environmental factors, as well as diet and exercise.

Published
2012

47. Sizing mitigation wetlands in agricultural watersheds

Author

Chelsea Spier, William T. Stringfellow, Jeremy S. Hanlon, Justin Graham, and M. Ekrem Karpuzcu

Subjects
Geological Phenomena, Environmental Engineering, Watershed, Removal kinetics, Wetland, California, chemistry.chemical_compound, Nitrate, Water Movements, Water Science and Technology, Hydrology, geography, Mass removal, geography.geographical_feature_category, Nitrates, business.industry, Agriculture, Kinetics, chemistry, Wetlands, Environmental science, San Joaquin, Microcosm, business, Water Pollutants, Chemical, Environmental Monitoring
Abstract

In this study, we investigated use of microcosms to supplement field studies for establishing the size of wetlands required to mitigate nitrate pollution in agricultural watersheds. Wetlands investigated in this study were located in San Joaquin Valley (California, USA) and demonstrated mean nitrate-nitrogen mass removal efficiencies ranging between 10 and 34%. Mean areal nitrate removal rates (J) ranged from 142 to 380 mg-N m −2 d −1 . First-order rate constants determined from field data had a high variance, with confidence intervals greater than 57% of mean values. Sediments and rooted plants from one site were placed in a flow-through microcosm and measurements of nitrate removal kinetics were made and compared with field results. The apparent half-saturation constant ( K m ) and maximum removal rate ( J max ) for nitrate-nitrogen were 43.8 mg/L and 4.11 g m −2 d −1 in the microcosm. The first-order rate constant from the microcosm (10.4 cm d −1 ) was in close agreement with the value for the field site (11.9 cm d −1 ) and had a confidence interval of less than 16%. Using this improved first-order rate constant, it was determined that between 1.3 and 3.6% of the land in the watershed should be managed as mitigation wetland, with the area required dependent on the level of nitrate reduction desired and how closely the wetland design approximates plug-flow.

Published
2012

48. Enhanced Sustainability of Dairy Operations through Implementation of a Biomass Energy Project

Author

Michael Jue, Mary Kay Camarillo, William T. Stringfellow, and Jeremy S. Hanlon

Subjects
Engineering, Anaerobic digestion, Payback period, Biogas, Waste management, business.industry, Waste heat, Environmental engineering, Biomass, Carbon credit, business, Tonne, Net present value
Abstract

A full-scale biomass energy system located at a dairy farm in Central California was rigorously studied for 15-months following construction in 2009 to determine the sustainability of continued operations. During that time period the anaerobic digesters produced 6,300 m3/d of biogas containing 49.7% methane, resulting in greenhouse gas reduction equivalent to 6,900 metric tons of carbon dioxide annually. Of the biogas produced 97.1% was used in a combined heat and power unit, which resulted in power production of 9,700 kWh/d. Revenues and cost savings from the project appeared sufficient to offset system costs (reduced by state and federal grants) over the 20 year projected lifespan of the project when a 4% discount rate was applied. The estimated net present value of the project was $1.1 million and the estimated payback period was 12.1 years. Sustainability of continued operations could be improved by operating the system closer to capacity, importing off-site digester feedstocks, obtaining carbon credits, and pursing additional use of waste heat.

Published
2012

49. Fiscalini Farms Biomass Energy Project

Author

Chelsea Spier, William T. Stringfellow, Jeremy S. Hanlon, Michael Jue, and Mary Kay Camarillo

Subjects
Energy crop, Anaerobic digestion, Engineering, Electricity generation, Power station, Waste management, business.industry, Greenhouse gas, Fossil fuel, Alternative energy, Environmental engineering, Biomass, business
Abstract

In this final report describes and documents research that was conducted by the Ecological Engineering Research Program (EERP) at the University of the Pacific (Stockton, CA) under subcontract to Fiscalini Farms LP for work under the Assistance Agreement DE-EE0001895 'Measurement and Evaluation of a Dairy Anaerobic Digestion/Power Generation System' from the United States Department of Energy, National Energy Technology Laboratory. Fiscalini Farms is operating a 710 kW biomass-energy power plant that uses bio-methane, generated from plant biomass, cheese whey, and cattle manure via mesophilic anaerobic digestion, to produce electricity using an internal combustion engine. The primary objectives of the project were to document baseline conditions for the anaerobic digester and the combined heat and power (CHP) system used for the dairy-based biomass-energy production. The baseline condition of the plant was evaluated in the context of regulatory and economic constraints. In this final report, the operation of the plant between start-up in 2009 and operation in 2010 are documented and an interpretation of the technical data is provided. An economic analysis of the biomass energy system was previously completed (Appendix A) and the results from that study are discussed briefly in this report. Results from the start-up and first year of operation indicate that mesophilic anaerobic digestion of agricultural biomass, combined with an internal combustion engine, is a reliable source of alternative electrical production. A major advantage of biomass energy facilities located on dairy farms appears to be their inherent stability and ability to produce a consistent, 24 hour supply of electricity. However, technical analysis indicated that the Fiscalini Farms system was operating below capacity and that economic sustainability would be improved by increasing loading of feedstocks to the digester. Additional operational modifications, such as increased utilization of waste heat and better documentation of potential of carbon credits, would also improve the economic outlook. Analysis of baseline operational conditions indicated that a reduction in methane emissions and other greenhouse gas savings resulted from implementation of the project. The project results indicate that using anaerobic digestion to produce bio-methane from agricultural biomass is a promising source of electricity, but that significant challenges need to be addressed before dairy-based biomass energy production can be fully integrated into an alternative energy economy. The biomass energy facility was found to be operating undercapacity. Economic analysis indicated a positive economic sustainability, even at the reduced power production levels demonstrated during the baseline period. However, increasing methane generation capacity (via the importation of biomass codigestate) will be critical for increasing electricity output and improving the long-term economic sustainability of the operation. Dairy-based biomass energy plants are operating under strict environmental regulations applicable to both power-production and confined animal facilities and novel approached are being applied to maintain minimal environmental impacts. The use of selective catalytic reduction (SCR) for nitrous oxide control and a biological hydrogen sulfide control system were tested at this facility. Results from this study suggest that biomass energy systems can be compliant with reasonable scientifically based air and water pollution control regulations. The most significant challenge for the development of biomass energy as a viable component of power production on a regional scale is likely to be the availability of energy-rich organic feedstocks. Additionally, there needs to be further development of regional expertise in digester and power plant operations. At the Fiscalini facility, power production was limited by the availability of biomass for methane generation, not the designed system capacity. During the baseline study period, feedstocks included manure, sudan grass silage, and refused-feed. The ability of the dairy to produce silage in excess of on-site feed requirements limited power production. The availability of biomass energy crops and alternative feedstocks, such as agricultural and food wastes, will be a major determinant to the economic and environmental sustainability of biomass based electricity production.

Published
2011

50. High sodium chloride diets injure arteries and raise mortality without changing blood pressure

Author

S Hanlon and Louis Tobian

Subjects
medicine.medical_specialty, medicine.medical_treatment, High sodium, Blood Pressure, Sodium Chloride, Chloride, Catheterization, Animal science, Weight Loss, Internal Medicine, Animals, Medicine, Mortality, Saline, Increase blood pressure, business.industry, Rats, Inbred Strains, Arteries, Diet, Rats, Surgery, Femoral Artery, Blood pressure, Creatinine, Deoxycorticosterone acetate, business, medicine.drug
Abstract

High NaCl diets often increase blood pressure and thereby accelerate lesions in arterial walls. Could high NaCl diets increase arterial lesions without raising blood pressure? To test this, 100 uninephrectomized Dahl salt-resistant (DR) rats (highly resistant to NaCl hypertension) were administered deoxycorticosterone acetate (DOCA) (250 mg/kg) in silicone implants and drinking water containing 1% NaCl for 6 weeks. Then the DOCA and saline were removed, and the rats were allowed to recover for 4 weeks. Intra-arterial mean blood pressures on all rats allowed division of the rats into two matched groups, each group with an average blood pressure of 160 mm Hg. One group continued on a 0.3% NaCl diet, whereas the other group began an 8% NaCl diet for 8 weeks. After 5 weeks on these two diets, the intra-arterial blood pressure averaged 158 mm Hg in both groups. Thus, the 8% NaCl diet produced no further increase in blood pressure in the DR rats. Nevertheless, after 8 weeks on the 8% NaCl diet, 53% of the rats (26 of 49) had died; whereas in the group on the 0.3% NaCl diet, not one rat (0 of 51) had died (p less than 0.000001). After 7 more weeks on the 8% NaCl diet, all the rats in this group had died.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1990

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