10 results on '"S. Garrè"'
Search Results
2. Impacts of soil management and climate on saturated and near-saturated hydraulic conductivity: analyses of the Open Tension-disk Infiltrometer Meta-database (OTIM)
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G. Blanchy, L. Albrecht, G. Bragato, S. Garré, N. Jarvis, and J. Koestel
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Technology ,Environmental technology. Sanitary engineering ,TD1-1066 ,Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 - Abstract
Saturated and near-saturated soil hydraulic conductivities Kh (mm h−1) determine the partitioning of precipitation into surface runoff and infiltration and are fundamental to soils' susceptibility to preferential flow. Recent studies found indications that climate factors influence Kh, which is highly relevant in the face of climate change. In this study, we investigated relationships between pedoclimatic factors and Kh and also evaluated effects of land use and soil management. To this end, we collated the Open Tension-disk Infiltrometer Meta-database (OTIM), which contains 1297 individual data entries from 172 different publication sources. We analysed a spectrum of saturated and near-saturated hydraulic conductivities at matric potentials between 0 and 100 mm. We found that methodological details like the direction of the wetting sequence or the choice of method for calculating infiltration rates to hydraulic conductivities had a large impact on the results. We therefore restricted ourselves to a subset of 466 of the 1297 data entries with similar methodological approaches. Correlations between Ks and Kh at higher supply tensions decreased especially close to saturation, indicating a different flow mechanism at and very close to saturation than towards the dry end of the investigated tension range. Climate factors were better correlated with topsoil near-saturated hydraulic conductivities at supply tensions ≥ 30 mm than soil texture, bulk density and organic carbon content. We find it most likely that the climate variables are proxies for soil macropore networks created by the respective biological activity, pedogenesis and climate-specific land use and management choices. Due to incomplete documentation in the source publications of OTIM, we were able to investigate only a few land use types and agricultural management practices. Land use, tillage system and soil compaction significantly influenced Kh, with effect sizes appearing comparable to the ones of soil texture and soil organic carbon. The data in OTIM show that experimental bias is present, introduced by the choice of measurement time relative to soil tillage, experimental design or data evaluation procedures. The establishment of best-practice rules for tension-disk infiltrometer measurements would therefore be helpful. Future studies are needed to investigate how climate shapes soil macropore networks and how land use and management can be adapted to improve soil hydraulic properties. Both tasks require large numbers of new measurement data with improved documentation on soil biology and land use and management history.
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- 2023
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3. Potential of natural language processing for metadata extraction from environmental scientific publications
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G. Blanchy, L. Albrecht, J. Koestel, and S. Garré
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Summarizing information from large bodies of scientific literature is an essential but work-intensive task. This is especially true in environmental studies where multiple factors (e.g., soil, climate, vegetation) can contribute to the effects observed. Meta-analyses, studies that quantitatively summarize findings of a large body of literature, rely on manually curated databases built upon primary publications. However, given the increasing amount of literature, this manual work is likely to require more and more effort in the future. Natural language processing (NLP) facilitates this task, but it is not clear yet to which extent the extraction process is reliable or complete. In this work, we explore three NLP techniques that can help support this task: topic modeling, tailored regular expressions and the shortest dependency path method. We apply these techniques in a practical and reproducible workflow on two corpora of documents: the Open Tension-disk Infiltrometer Meta-database (OTIM) and the Meta corpus. The OTIM corpus contains the source publications of the entries of the OTIM database of near-saturated hydraulic conductivity from tension-disk infiltrometer measurements (https://github.com/climasoma/otim-db, last access: 1 March 2023). The Meta corpus is constituted of all primary studies from 36 selected meta-analyses on the impact of agricultural practices on sustainable water management in Europe. As a first step of our practical workflow, we identified different topics from the individual source publications of the Meta corpus using topic modeling. This enabled us to distinguish well-researched topics (e.g., conventional tillage, cover crops), where meta-analysis would be useful, from neglected topics (e.g., effect of irrigation on soil properties), showing potential knowledge gaps. Then, we used tailored regular expressions to extract coordinates, soil texture, soil type, rainfall, disk diameter and tensions from the OTIM corpus to build a quantitative database. We were able to retrieve the respective information with 56 % up to 100 % of all relevant information (recall) and with a precision between 83 % and 100 %. Finally, we extracted relationships between a set of drivers corresponding to different soil management practices or amendments (e.g., “biochar”, “zero tillage”) and target variables (e.g., “soil aggregate”, “hydraulic conductivity”, “crop yield”) from the source publications' abstracts of the Meta corpus using the shortest dependency path between them. These relationships were further classified according to positive, negative or absent correlations between the driver and the target variable. This quickly provided an overview of the different driver–variable relationships and their abundance for an entire body of literature. Overall, we found that all three tested NLP techniques were able to support evidence synthesis tasks. While human supervision remains essential, NLP methods have the potential to support automated evidence synthesis which can be continuously updated as new publications become available.
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- 2023
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4. Soil and crop management practices and the water regulation functions of soils: a qualitative synthesis of meta-analyses relevant to European agriculture
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G. Blanchy, G. Bragato, C. Di Bene, N. Jarvis, M. Larsbo, K. Meurer, and S. Garré
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Adopting soil and crop management practices that conserve or enhance soil structure is critical for supporting the sustainable adaptation of agriculture to climate change, as it should help maintain agricultural production in the face of increasing drought or water excess without impairing environmental quality. In this paper, we evaluate the evidence for this assertion by synthesizing the results of 34 published meta-analyses of the effects of such practices on soil physical and hydraulic properties relevant for climate change adaptation in European agriculture. We also review an additional 127 meta-analyses that investigated synergies and trade-offs or help to explain the effects of soil and crop management in terms of the underlying processes and mechanisms. Finally, we identify how responses to alternative soil–crop management systems vary under contrasting agro-environmental conditions across Europe. This information may help practitioners and policymakers to draw context-specific conclusions concerning the efficacy of management practices as climate adaptation tools. Our synthesis demonstrates that organic soil amendments and the adoption of practices that maintain “continuous living cover” result in significant benefits for the water regulation function of soils, mostly arising from the additional carbon inputs to soil and the stimulation of biological processes. These effects are clearly related to improved soil aggregation and enhanced bio-porosity, both of which reduce surface runoff and increase infiltration. One potentially negative consequence of these systems is a reduction in soil water storage and groundwater recharge, which may be problematic in dry climates. Some important synergies are reductions in nitrate leaching to groundwater and greenhouse gas emissions for nonleguminous cover crop systems. The benefits of reducing tillage intensity appear much less clear-cut. Increases in soil bulk density due to traffic compaction are commonly reported. However, biological activity is enhanced under reduced tillage intensity, which should improve soil structure and infiltration capacity and reduce surface runoff and the losses of agro-chemicals to surface water. However, the evidence for these beneficial effects is inconclusive, while significant trade-offs include yield penalties and increases in greenhouse gas emissions and the risks of leaching of pesticides and nitrate. Our synthesis also highlights important knowledge gaps on the effects of management practices on root growth and transpiration. Thus, conclusions related to the impacts of management on the crop water supply and other water regulation functions are necessarily based on inferences derived from proxy variables. Based on these knowledge gaps, we outlined several key avenues for future research on this topic.
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- 2023
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5. Evaluation of Southern Ocean cloud in the HadGEM3 general circulation model and MERRA-2 reanalysis using ship-based observations
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P. Kuma, A. J. McDonald, O. Morgenstern, S. P. Alexander, J. J. Cassano, S. Garrett, J. Halla, S. Hartery, M. J. Harvey, S. Parsons, G. Plank, V. Varma, and J. Williams
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Southern Ocean (SO) shortwave (SW) radiation biases are a common problem in contemporary general circulation models (GCMs), with most models exhibiting a tendency to absorb too much incoming SW radiation. These biases have been attributed to deficiencies in the representation of clouds during the austral summer months, either due to cloud cover or cloud albedo being too low. The problem has been the focus of many studies, most of which utilised satellite datasets for model evaluation. We use multi-year ship-based observations and the CERES spaceborne radiation budget measurements to contrast cloud representation and SW radiation in the atmospheric component Global Atmosphere (GA) version 7.1 of the HadGEM3 GCM and the MERRA-2 reanalysis. We find that the prevailing bias is negative in GA7.1 and positive in MERRA-2. GA7.1 performs better than MERRA-2 in terms of absolute SW bias. Significant errors of up to 21 W m−2 (GA7.1) and 39 W m−2 (MERRA-2) are present in both models in the austral summer. Using ship-based ceilometer observations, we find low cloud below 2 km to be predominant in the Ross Sea and the Indian Ocean sectors of the SO. Utilising a novel surface lidar simulator developed for this study, derived from an existing Cloud Feedback Model Intercomparison Project (CFMIP) Observation Simulator Package (COSP) – active remote sensing simulator (ACTSIM) spaceborne lidar simulator, we find that GA7.1 and MERRA-2 both underestimate low cloud and fog occurrence relative to the ship observations on average by 4 %–9 % (GA7.1) and 18 % (MERRA-2). Based on radiosonde observations, we also find the low cloud to be strongly linked to boundary layer atmospheric stability and the sea surface temperature. GA7.1 and MERRA-2 do not represent the observed relationship between boundary layer stability and clouds well. We find that MERRA-2 has a much greater proportion of cloud liquid water in the SO in austral summer than GA7.1, a likely key contributor to the difference in the SW radiation bias. Our results suggest that subgrid-scale processes (cloud and boundary layer parameterisations) are responsible for the bias and that in GA7.1 a major part of the SW radiation bias can be explained by cloud cover underestimation, relative to underestimation of cloud albedo.
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- 2020
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6. 238 Gemcitabine (GEM) as salvage treatment in patients (pts) with advanced colorectal cancer (CRC) progressing after treatment with 5-fluorouracil (FU), irinotecan (lrl) and oxaliplatin (oxa)
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L. Gallo, C. Caroti, C. Aschele, Mauro D'Amico, Sara Lonardi, S. Garrè, Silvio Monfardini, P. Pronzato, Micaela Stefani, and L.M. Pasetto
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Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Salvage treatment ,Gemcitabine ,Oxaliplatin ,Irinotecan ,Advanced colorectal cancer ,Fluorouracil ,Internal medicine ,medicine ,In patient ,business ,After treatment ,medicine.drug - Published
- 2003
7. 284 DCC protein expression in colorectal cancer (CRC) metastases and lack of response to biochemically-modulated 5-fluorouracil (FU) among patients (pts) with low level of thymidylate synthase (TS) protein expression
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Domizia Debernardis, S. Casazza, S. Garrè, C. Aschele, Silvio Monfardini, Sara Lonardi, and L. Gallo
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Oncology ,Cancer Research ,medicine.medical_specialty ,biology ,business.industry ,Colorectal cancer ,medicine.disease ,Thymidylate synthase ,Protein expression ,Fluorouracil ,Internal medicine ,biology.protein ,Medicine ,business ,medicine.drug - Published
- 2003
8. Characterization of stony soils' hydraulic conductivity using laboratory and numerical experiments
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E. Beckers, M. Pichault, W. Pansak, A. Degré, and S. Garré
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Determining soil hydraulic properties is of major concern in various fields of study. Although stony soils are widespread across the globe, most studies deal with gravel-free soils, so that the literature describing the impact of stones on the hydraulic conductivity of a soil is still rather scarce. Most frequently, models characterizing the saturated hydraulic conductivity of stony soils assume that the only effect of rock fragments is to reduce the volume available for water flow, and therefore they predict a decrease in hydraulic conductivity with an increasing stoniness. The objective of this study is to assess the effect of rock fragments on the saturated and unsaturated hydraulic conductivity. This was done by means of laboratory experiments and numerical simulations involving different amounts and types of coarse fragments. We compared our results with values predicted by the aforementioned predictive models. Our study suggests that it might be ill-founded to consider that stones only reduce the volume available for water flow. We pointed out several factors of the saturated hydraulic conductivity of stony soils that are not considered by these models. On the one hand, the shape and the size of inclusions may substantially affect the hydraulic conductivity. On the other hand, laboratory experiments show that an increasing stone content can counteract and even overcome the effect of a reduced volume in some cases: we observed an increase in saturated hydraulic conductivity with volume of inclusions. These differences are mainly important near to saturation. However, comparison of results from predictive models and our experiments in unsaturated conditions shows that models and data agree on a decrease in hydraulic conductivity with stone content, even though the experimental conditions did not allow testing for stone contents higher than 20 %.
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- 2016
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9. Technetium-99m-sestamibi scintigraphy in multiple myeloma and related gammopathies: a useful tool for the identification and follow-up of myeloma bone disease.
- Author
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Balleari E, Villa G, Garrè S, Ghirlanda P, Agnese G, Carletto M, Clavio M, Ferrando F, Gobbi M, Mariani G, and Ghio R
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- Adult, Aged, Aged, 80 and over, Bone Marrow diagnostic imaging, Bone Marrow pathology, Bone Neoplasms diagnostic imaging, Bone Neoplasms pathology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Paraproteinemias diagnostic imaging, Radionuclide Imaging, Multiple Myeloma diagnostic imaging, Technetium Tc 99m Sestamibi
- Abstract
Background and Objectives: Technetium-99m 2-methoxy-isobutyl-isonitrile ((99m)Tc-sestamibi) has recently been proposed as a potential tracer in patients with multiple myeloma (MM), as its increased uptake in the bone marrow has been reported as indicator of myeloma activity. We evaluated the role of (99m)Tc-sestamibi scintigraphy in the detection of myeloma bone disease in MM and related gammopathies, and also assessed its relationship with clinical status and stage of the disease, focusing in particular on the early follow-up of a small series of MM patients treated with high-dose therapy., Design and Methods: Forty-six consecutive patients affected by MM or monoclonal gammopathy of undefined significance (MGUS) were studied by whole body scans obtained 20 minutes after administration of 740 MBq of (99m)Tc-sestamibi. A semiquantitative uptake score was used and scintigraphic findings were correlated with clinical and laboratory data., Results: All the MGUS patients showed a negative (99m)Tc-sestamibi scan. Among the 32 MM patients (25 with active disease and 7 in clinical remission) 24 showed a positive scan, while 8 presented only a physiologic uptake of the tracer. The uptake score correlated significantly with all the most relevant clinical variables. In the follow-up of 8 MM patients treated with high-dose chemotherapy (99m)Tc-sestamibi closely paralleled the activity of myeloma bone disease. Comparison with X-ray skeletal survey showed discordant results in 14 out of the overall 56 scans obtained (27%), with 10 cases of negative (99m)Tc-sestamibi scans but lytic bone lesions revealed by X-ray (7 of them were in clinical remission), and 4 negative X-ray surveys in patients with positive (99m)Tc-sestamibi scans. Overall sensitivity and specificity of (99m)Tc-sestamibi scintigraphy in detecting myeloma bone disease were 90% and 88%, respectively., Interpretation and Conclusions: This study provides additional evidence indicating that (99m)Tc-sestamibi scintigraphy closely reflects myeloma disease activity in bone marrow, with very high sensitivity and specificity. (99m)Tc-sestamibi scintigraphy is therefore suggested as a reliable new tool for the staging and follow-up of myeloma bone disease.
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- 2001
10. Gender-related analysis of thrombopoietic cytokine pattern in patients with immune thrombocytopenic purpura.
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Balleari E, Ghirlanda P, Garrè S, Casciaro S, Massa G, and Ghio R
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- Adolescent, Adult, Aged, Cytokines blood, Female, Humans, Interleukin-11 blood, Interleukin-3 blood, Interleukin-6 blood, Male, Middle Aged, Thrombopoietin blood, Cytokines physiology, Purpura, Thrombocytopenic, Idiopathic blood, Sex Characteristics, Thrombosis etiology
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- 1999
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