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Of all the world thinkers on whom the author of The Philosophy of the Common Task [Filosofiia obshchego dela] reflected, the one to whom he devoted the most attention, thought, and passion was perhaps a contemporary of his who, though fifteen years his junior, had already thrown some "impossible" works in the face of a fascinated, flabbergasted, and shocked public and had lived for almost ten years outside the world of culture and history, in a state of complete insanity. I speak, of course, of Friedrich Nietzsche. He burst into Russia as a deafening European intellectual novelty, which intoxicated and swept away quite a few young people and even some experienced wise heads with the audacity of his "transvaluation of all values," his prophetic eruptions of new ideas and life principles, his exciting style of free philosophizing, and, finally, his existential tragedy. Fedorov could not but have been sensitive to and, I would say, personally affected by this phenomenon-Nietzsche and Nietzscheanism and the f...

Effect of morphine and naloxone on nociceptive sensitivity were studied in 3 rat strains, with high, low, and intermediate thresholds of nervous system excitability. The highest sensitivity to morphine correlated with its dose dependence was revealed in rats with low and high thresholds of excitability. The lowest sensitivity was found in rats with intermediate thresholds of excitability. The obtained data led to the conclusion about essential contribution of genetical control of excitability in the mechanisms of functioning of the opiate system.

Rat experiments have shown that the histograms of intervals between the self-injections of narcotic analgesics (morphine, promedol, buprenorphine) and psychomotor stimulants (cocaine, amphetamine) were essentially different. The quantitative measures of these differences are presented as discrepancy coefficients in the interval distribution between self-injections. The computerized "real time" system for collecting and analyzing the experimental findings of intravenous self-injection was used in rats.