Search

The Kuialnyk Estuary belongs to the group of closed estuaries of the Northwestern Black Sea coast and is a unique water body of national importance with therapeutic properties. The natural territories of the Kuialnyk Estuary were declared as a resort of national importance and form a part of the Kuialnyk National Nature Park. The purpose of the research is to introduce the results of the hydrological, hydrochemical, hydrobiological and medico-biological studies of the condition of the Kuialnyk Estuary and seawater in the Odesa Bay that were conducted in 2021 and to compare them with the results of previous years. This would help to determine the conditions under which the estuary’s natural system is functioning, to ensure preservation and restoration of its natural resources, to prevent their pollution, clogging and depletion, as well as to identify changes of the natural resources of the Kuialnyk Estuary in the context of its artificial replenishment with seawater from the Odesa Bay and varying hydro-ecological factors. The general conclusion is as follows: replenishment of the estuary with seawater during the cold period of 2020-2021, increasing amount of atmospheric precipitation and decreasing rate of evaporation from the estuary’s water surface in 2021 raised the Kuialnyk Estuary’s water level. This led to significant improvement of the estuary’s hydro-ecological condition compared to 2020, however, because of its contamination with petroleum hydrocarbons, some toxic and polycyclic aromatic hydrocarbons, the water quality in 2021 is still assessed as satisfactory. The quality of the bottom sediments of the Kuialnyk Estuary from the environmental perspective is assessed as very poor because of their contamination with petroleum hydrocarbons, organochlorine pesticides and polycyclic aromatic hydrocarbons. The physicochemical composition of colloidal dispersions of the Kuialnyk Estuary’s peloids is barely different as compared to previous years. As per indicators of Eh (2017-2021) and pH (2020-2021), the quality of the peloids within the area used by the sanatorium did not meet the established conditions and the Medical (Balneological) Conclusion. Compared to 2020, the sanitary and microbiological condition of peloids improved in 2021, however, was still unsatisfactory. The characteristics of peloids’ biological activity during different periods of studies correlate with general mineralization fluctuations. Maintaining oil mineralization at a level not higher than 250 g/dm3 is quite important in order to preserve the unique deposit of natural healing resources of the Kuialnyk Estuary. Therefore, solving the following problems remains a priority: reducing the mineralization of the estuary’s water via increase of the rate of clean fresh water supply from various sources instead of using salty seawater; preventing the pollution from anthropogenic sources from entering the estuary (through water runoff from the watercourses flowing into the Kuialnyk Estuary such as the chute from the sandbar, Korsuntsivska and Hildendorfska gullies and others).

In experiments on rats of the Wi-star line, the influence of two iron-containing weakly mineralized mineral waters with a high content of organic matter (MW) from the sources № 13 and № 15 of Skhidnytsia deposit (Ukraine). It was determined that both MW do not have a toxic effect on their use on animals, as evidenced by the lack of significant structural and functional changes in the tissues of the stomach, kidneys, liver, and heart. It is established that MW from source No. 13 changes the activity of transamination processes in hepatocytes, increases bile formation and biliary excretion, and activates red blood counts. MW from source No. 15 has a similar effect, but more significantly affects the metabolism, red blood, and immune system. The research results justify the use of these iron-containing MW for the correction of iron deficiency conditions in laboratory animals.

The article presents the results of studies that indicate that with hypertrophy of the lingual tonsil, weakening of the resistance of the oral mucosa to external influences is observed. This is due to sensitization, intoxication, depletion of the body by various pathogens that disrupt the regulation and repair processes in the body.

The article reviews the pathogenesis and the course of autism. Authors define autism as a psychosomatic disorder. A distinctive feature of mineral waters, as natural therapeutic factors of weak intensity, is their pronounced biological activity, the absence of side effects and the possibility of long-term use in combination with medication therapy. The paper presents data substantiating the possibility of using mineral water with an increased content of organic substances for the correction of the somatic component of autism (problems of the gastrointestinal tract, carbohydrate metabolism disorders, neurosis).

The article presents data on the effect of silicon-containing mineral waters (MW) and their artificial analogues with the corresponding content of metasilicic acid on the state of the stomach wall in the modeling of gastritis in white rats. It was established that the use of MW with different content of metasilicic acid has a unidirectional, positive effect on the course of gastritis. MW with greater mineralization, molarity and high content of methacrylic acid completely eliminate inflammation and moderately stimulate reparative processes. In the application of MW with less mineralization, molarity and lower content of metasilicic acid, there were definitive inflammation manifestations, but the manifestations of reparative processes were more pronounced. The same trend was observed with the use of artificial analogues - model solutions on distilled water with the corresponding content of metasilicic acid. It is determined the same restorative in the direction, but much weaker corrective effect than the corresponding MW. The important component of the corrective action of these silicon MW when used in animals with gastritis is determined by the peculiarities of the macro component composition and the proportion of the main macro components - Na +, K +, Mg2 +, Ca2 +, НСО3, Cl-, SO42- and, to a lesser extent, silicon content.

Under certain conditions, skin damage may be accompanied by a complication in the form of hypertrophic scars, keloids. A significant role in the pathogenesis of the development of keloids is attributed to immune mechanisms, neuro-endocrine disorders, hereditary factors. The most effective way to treat keloid scars is still surgical. At the same time, simple excision of keloid stimulates additional collagen synthesis, increases the risk of relapse. Traditionally used steroid drugs, metered pressure, X-rays and radiotherapy. However, these methods can lead to undesirable consequences, which justifies the search for new, less aggressive methods. To increase the effectiveness of treatment of keloids of the earlobe using a new medical complex consisting of cryotherapy, a course of injections of the drug based on hyaluronidase and a course of drawing of sulphide-peloid extracts. A study of the state of keloid scar after cryodestruction and subsequent use of the drug based on hyaluronidase was carried out in 14 people. The cryoexposure was carried out by the two-cycle method with an exposure time of 30 to 90 s. To increase the efficiency and improve the performance in the complex treatment, a spinner made of silt-sulfide peloids was used, whose components stimulate collagen resorption by fibroclasts. As a result of treatment, all patients showed a significant improvement: subsidence of paresthesia, itching, leveling the height of keloid in relation to unchanged skin. Findings. The results obtained allow us to recommend the proposed method for the introduction into the practice of cosmetologists and otorhinolaryngologists.

The article is devoted to the study of the influence of arsenic mineral water (MW) with its internal application to the organism of healthy white rats. MW does not have toxic effects and does not cause pathological changes in the organism of animals. There was established a slight sedative effect on the functional state of the central nervous system and emotional activity of animals, a significant stimulating effect on the functional state of the kidneys and a moderate stimulating effect on the bile-excretory function of the liver. A decrease in the activity of aerobic oxidation in the tissues of the studied organs (stomach, liver, kidneys) was detected. Directions for further experimental studies are formulated.

The article reviews the pathogenesis and the course of autism. Authors define autism as a psychosomatic disorder. A distinctive feature of mineral waters, as natural therapeutic factors of weak intensity, is their pronounced biological activity, the absence of side effects and the possibility of long-term use in combination with medication therapy. The paper presents data substantiating the possibility of using mineral water with an increased content of organic substances for the correction of the somatic component of autism (problems of the gastrointestinal tract, carbohydrate metabolism disorders, neurosis).

Dragomiretska N. V., Zabolotna I. B., Gushcha S. G. Пути коррекции инсулинорезистентности. Роль бишофита = Ways of correction of insulin resistance. The role of bishofite. Journal of Education, Health and Sport. 2015;5(9):663-670. ISSN 2391-8306. DOI10.5281/zenodo.31762 http://dx.doi.org/10.5281/zenodo.31762 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%289%29%3A663-670 https://pbn.nauka.gov.pl/works/642311 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.08.2015. Revised 05.09.2015. Accepted: 29.09.2015. ПУТИ КОРРЕКЦИИ ИНСУЛИНОРЕЗИСТЕНТНОСТИ. РОЛЬ БИШОФИТА WAYS OF CORRECTION OF INSULIN RESISTANCE. THE ROLE OF BISHOFITE Н. В. Драгомирецкая, И. Б. Заболотная, С. Г. Гуща N. V. Dragomiretska, I. B. Zabolotna, S. G. Gushcha Государственное учреждение «Украинский научно-исследовательский институт медицинской реабилитации и курортологи МЗ Украины», Одесса State Institution «Ukrainian Scientific Research Institute of Medical Rehabilitation and Resort Therapy of the Ministry of Health of Ukraine», Odessa Abstract The state of insulin resistance was reproduced in white Wistar rats by injection of alloxan in the original dosage. This state was characterized by increased level of glucose during glucose tolerance test. Two-week internal application of aqueous solution of Poltava bishofite prevented disruption of the basal level of glucose in the blood of rats. The obtained data served as an experimental justification of application of bishofite in clinical practice on patients with the syndrome of insulin resistance affected by nonalcoholic fatty liver disease. Decrease in concentration of total cholesterol, triglycerides and tendency to decrease in low density lipoprotein were noted after one month of application of the Poltava bishofite by these patients. Glucose level of the blood serum in the treatment process did not change significantly but insulin level decreased significantly, i.e. effectiveness of insulin activity increased. This resulted in a decrease of HOMA-IR index especially for patients with baseline hyperinsulinemia with insulin level decreasing in 1.6 times during treatment. Keywords: aqueous solution of Poltava bishofite, insulin resistance. Реферат У белых крыс линии Вистар было воспроизведено состояние инсулинорезистентности путем введения аллоксана в оригинальной дозировке. Это состояние характеризовалось повышением уровня глюкозы при проведении теста толерантности к глюкозе. Двухнедельное внутреннее применение водного раствора Полтавского бишофита предотвращало нарушение базального уровня глюкозы в крови крыс. Полученные данные послужили експериментальным обоснованием применения бишофита в клинической практике у больных с синдромом инсулинорезистентности на фоне неалкогольной жировой болезни печени. У этих больных после месячного приема Полтавского бишофита было установлено уменьшение концентрации общего холестерина, триглицеридов, тенденция к уменьшению липопротеидов низкой плотности. Уровень глюкозы сыворотки крови в процессе лечения существенно не изменился, но уровень инсулина значительно снизился, т.е., эффективность инсулиновой активности повысилась. Это привело к снижению индекса НОМА-IR особенно у больных с исходной гиперинсулинемией, у которых уровень инсулина в процессе лечения снизился в 1,6 раза. Ключевые слова: водный раствор Полтавской бишофит, резистентность к инсулину.

Gushcha S. G. Наукове обгрунтування оздоровлюючого лікувального застосування мінеральної води з підвищенним умістом органічних речовин при психоемоційних розладах = Scientific substantiation of health-improving medical application of mineral water with higt content of organic substances at psycho-emotional disorders. Journal of Education, Health and Sport. 2015;5(6):496-502. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.31895 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%286%29%3A496-502 https://pbn.nauka.gov.pl/works/646301 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.04.2015. Revised 05.05.2015. Accepted: 06.06.2015. НАУКОВЕ ОБГРУНТУВАННЯ ОЗДОРОВЛЮЮЧОГО ЛІКУВАЛЬНОГО ЗАСТОСУВАННЯ МІНЕРАЛЬНОЇ ВОДИ З ПІДВИЩЕННИМ УМІСТОМ ОРГАНІЧНИХ РЕЧОВИН ПРИ ПСИХОЕМОЦІЙНИХ РОЗЛАДАХ SCIENTIFIC SUBSTANTIATION OF HEALTH-IMPROVING MEDICAL APPLICATION OF MINERAL WATER WITH HIGT CONTENT OF ORGANIC SUBSTANCES AT PSYCHO-EMOTIONAL DISORDERS С. Г. Гуща S. G. Gushcha Государственное учреждение «Украинский научно-исследовательский институт медицинской реабилитации и курортологи МЗ Украины», Одесса State Institution «Ukrainian Scientific Research Institute of Medical Rehabilitation and Resort Therapy of the Ministry of Health of Ukraine», Odessa Abstract Experimental studies have established a mild calming effect of mineral water with a high content of organic substances "Zbruchanskaya" on the functional state of the central nervous system and the emotional strain of the animals. This character of the biological activity allowed us to determine the direction of further clinical trials. The group of persons with psycho-emotional disorders drank mineral water "Zbruchanskaya" a daily dose of 1% of body weight 3 times a day for 40 minutes before a meal, a course of 21 days. Application of mineral water "Zbruchanskaya" leads to the normalization of psychoemotional condition at 80% of the investigated. At the end of treatment remained only weakly manifestation of psychoemotional disorders. Keywords: functional state of the central nervous system and the emotional strain of experimental animals, correction of psycho-emotional disorders in patients, mineral water "Zbruchanskaya". Реферат Експериментальними дослідженнями встановлено м’який заспокійливий вплив мінеральної води з підвищеним умістом органічних речовин «Збручанська» на функціональний стан центральної нервової системи та емоційну напруженість тварин. Такий характер біологічної активності дозволив визначити напрямок подальших клінічних випробувань. У осіб з психо-емоційними розладами, які вживали мінеральну воду «Збручанська» встановлено нормалізація психоемоційниого стану у 80 % випадків. Наприкінці лікування зберігались лише осточні прояви психоемоційних розладів. Ключові слова: функціональний стан центральної нервової системи та емоційна напруга експериментальних тварин, корекція психоемоційних розладів у хворих, мінеральна вода «Збручанська».