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1. Comparison of somatostatin receptor expression in patients with neuroendocrine tumours with and without somatostatin analogue treatment imaged with [18F]SiTATE

Author

Ralf S. Eschbach, Markus Hofmann, Lukas Späth, Gabriel T. Sheikh, Astrid Delker, Simon Lindner, Klaus Jurkschat, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Reinhold Tiling, Matthias Brendel, Vera Wenter, Franziska J. Dekorsy, Mathias J. Zacherl, Andrei Todica, Harun Ilhan, Freba Grawe, Clemens C. Cyran, Marcus Unterrainer, Johannes Rübenthaler, Thomas Knösel, Tanja Paul, Stefan Boeck, Christoph Benedikt Westphalen, Christine Spitzweg, Christoph J. Auernhammer, Peter Bartenstein, Lena M. Unterrainer, and Leonie Beyer

Subjects
NET, PET/CT, [18F]SiTATE, somatostatin analogues, somatostatin receptor, molecular imaging, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

PurposeSomatostatin analogues (SSA) are frequently used in the treatment of neuroendocrine tumours. Recently, [18F]SiTATE entered the field of somatostatin receptor (SSR) positron emission tomography (PET)/computed tomography (CT) imaging. The purpose of this study was to compare the SSR-expression of differentiated gastroentero-pancreatic neuroendocrine tumours (GEP-NET) measured by [18F]SiTATE-PET/CT in patients with and without previous treatment with long-acting SSAs to evaluate if SSA treatment needs to be paused prior to [18F]SiTATE-PET/CT.Methods77 patients were examined with standardised [18F]SiTATE-PET/CT within clinical routine: 40 patients with long-acting SSAs up to 28 days prior to PET/CT examination and 37 patients without pre-treatment with SSAs. Maximum and mean standardized uptake values (SUVmax and SUVmean) of tumours and metastases (liver, lymphnode, mesenteric/peritoneal and bones) as well as representative background tissues (liver, spleen, adrenal gland, blood pool, small intestine, lung, bone) were measured, SUV ratios (SUVR) were calculated between tumours/metastases and liver, likewise between tumours/metastases and corresponding specific background, and compared between the two groups.ResultsSUVmean of liver (5.4 ± 1.5 vs. 6.8 ± 1.8) and spleen (17.5 ± 6.8 vs. 36.7 ± 10.3) were significantly lower (p < 0.001) and SUVmean of blood pool (1.7 ± 0.6 vs. 1.3 ± 0.3) was significantly higher (p < 0.001) in patients with SSA pre-treatment compared to patients without. No significant differences between tumour-to-liver and specific tumour-to-background SUVRs were observed between both groups (all p > 0.05).ConclusionIn patients previously treated with SSAs, a significantly lower SSR expression ([18F]SiTATE uptake) in normal liver and spleen tissue was observed, as previously reported for 68Ga-labelled SSAs, without significant reduction of tumour-to-background contrast. Therefore, there is no evidence that SSA treatment needs to be paused prior to [18F]SiTATE-PET/CT.

Published
2023
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2. Identification and characterization of myocardial metastases in neuroendocrine tumor patients using 68Ga-DOTATATE PET-CT

Author

Wolfgang G. Kunz, Ralf S. Eschbach, Robert Stahl, Philipp M. Kazmierczak, Peter Bartenstein, Axel Rominger, Christoph J. Auernhammer, Christine Spitzweg, Jens Ricke, and Clemens C. Cyran

Subjects
Myocardium, Neuroendocrine tumors, Positron-emission tomography, Multidetector computed tomography, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Focal 68Ga-DOTATATE PET lesions within the myocardium of neuroendocrine tumor (NET) patients are observed in clinical practice. We determined the frequency and characteristics of lesions that are consistent with cardiac metastasis and assessed the lesion detection rate of conventional imaging. Methods 629 patients who underwent 68Ga-DOTATATE PET-CT at a supraregional comprehensive cancer center on NET were included from a consecutive registry. Inclusion criteria were: (1) focal 68Ga-DOTATATE tracer uptake within the myocardium in more than two sequential PET exams, and (2) contrast-enhanced CT. To determine the diagnostic accuracy of conventional CT imaging, a case-control cohort with a ratio of 1:3 was used. PET and CT were independently analyzed by two blinded readers. Cohen’s κ was assessed for interreader agreement. Descriptive statistics were applied for frequencies and characteristics and group comparisons were analyzed using the Fisher’s exact test. Results The prevalence of myocardial metastases related to the registry was 2.4% (15 of 629 NET patients fulfilling the inclusion criteria), for a total of 21 myocardial 68Ga-DOTATATE foci detected. Myocardial lesions were most frequently located in the left ventricle (43%) and the septum (43%). No patient demonstrated a pericardial effusion. Patients with myocardial metastases did not differ in demographics, tumor grading, disease stage or circulating tumor markers compared to the overall registry (all p > 0.05). Higher Ki67-Indices were observed (p = 0.049) for patients with myocardial metastases. Interreader agreement for PET assessment was excellent (Cohen’s κ = 1.0). CT reading showed a sensitivity of 19% (95% confidence interval: 6–43%) at a specificity of 100% (95% confidence interval: 90–100%). Conclusions 68Ga-DOTATATE PET enables detection of myocardial metastatic lesions in NET patients. In contrast, standard morphologic CT imaging provides very limited sensitivity.

Published
2018
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3. 18F–FDG-PET/CT and diffusion-weighted MRI for monitoring a BRAF and CDK 4/6 inhibitor combination therapy in a murine model of human melanoma

Author

Ralf S. Eschbach, Philipp M. Kazmierczak, Maurice M. Heimer, Andrei Todica, Heidrun Hirner-Eppeneder, Moritz J. Schneider, Georg Keinrath, Olga Solyanik, Jessica Olivier, Wolfgang G. Kunz, Maximilian F. Reiser, Peter Bartenstein, Jens Ricke, and Clemens C. Cyran

Subjects
Melanoma, BRAF inhibitor, CDK inhibitor, 18F–FDG-PET, Diffusion-weighted MRI, Therapy monitoring, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The purpose of the study was to investigate a novel BRAF and CDK 4/6 inhibitor combination therapy in a murine model of BRAF-V600-mutant human melanoma monitored by 18F–FDG-PET/CT and diffusion-weighted MRI (DW-MRI). Methods Human BRAF-V600-mutant melanoma (A375) xenograft-bearing balb/c nude mice (n = 21) were imaged by 18F–FDG-PET/CT and DW-MRI before (day 0) and after (day 7) a 1-week BRAF and CDK 4/6 inhibitor combination therapy (n = 12; dabrafenib, 20 mg/kg/d; ribociclib, 100 mg/kg/d) or placebo (n = 9). Animals were scanned on a small animal PET after intravenous administration of 20 MBq 18F–FDG. Tumor glucose uptake was calculated as the tumor-to-liver-ratio (TTL). Unenhanced CT data sets were subsequently acquired for anatomic coregistration. Tumor diffusivity was assessed by DW-MRI using the apparent diffusion coefficient (ADC). Anti-tumor therapy effects were assessed by ex vivo immunohistochemistry for validation purposes (microvascular density – CD31; tumor cell proliferation – Ki-67). Results Tumor glucose uptake was significantly suppressed under therapy (∆TTLTherapy − 1.00 ± 0.53 vs. ∆TTLControl 0.85 ± 1.21; p

Published
2018
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4. Integrin-targeted quantitative optoacoustic imaging with MRI correlation for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma.

Author

Philipp M Kazmierczak, Neal C Burton, Georg Keinrath, Heidrun Hirner-Eppeneder, Moritz J Schneider, Ralf S Eschbach, Maurice Heimer, Olga Solyanik, Andrei Todica, Maximilian F Reiser, Jens Ricke, and Clemens C Cyran

Subjects
Medicine, Science
Abstract

PURPOSE:To investigate αvβ3-integrin-targeted optoacoustic imaging and MRI for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. MATERIALS AND METHODS:Human BRAF V600E-positive melanoma xenograft (A375)-bearing Balb/c nude mice (n = 10) were imaged before (day 0) and after (day 7) a BRAF/MEK inhibitor combination therapy (encorafenib, 1.3 mg/kg/d; binimetinib, 0.6 mg/kg/d, n = 5) or placebo (n = 5), respectively. Optoacoustic imaging was performed on a preclinical system unenhanced and 5 h after i. v. injection of an αvβ3-integrin-targeted fluorescent probe. The αvβ3-integrin-specific tumor signal was derived by spectral unmixing. For morphology-based tumor response assessments, T2w MRI data sets were acquired on a clinical 3 Tesla scanner. The imaging results were validated by multiparametric immunohistochemistry (ß3 -integrin expression, CD31 -microvascular density, Ki-67 -proliferation). RESULTS:The αvβ3-integrin-specific tumor signal was significantly reduced under therapy, showing a unidirectional decline in all animals (from 7.98±2.22 to 1.67±1.30; p = 0.043). No significant signal change was observed in the control group (from 6.60±6.51 to 3.67±1.93; p = 0.500). Immunohistochemistry revealed a significantly lower integrin expression (ß3: 0.20±0.02 vs. 0.39±0.05; p = 0.008) and microvascular density (CD31: 119±15 vs. 292±49; p = 0.008) in the therapy group. Tumor volumes increased with no significant intergroup difference (therapy: +107±42 mm3; control +112±44mm3, p = 0.841). In vivo blocking studies with αvβ3-integrin antagonist cilengitide confirmed the target specificity of the fluorescent probe. CONCLUSIONS:αvβ3-integrin-targeted optoacoustic imaging allowed for the early non-invasive monitoring of a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma, adding molecular information on tumor receptor status to morphology-based tumor response criteria.

Published
2018
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5. 68Ga-TRAP-(RGD)3 Hybrid Imaging for the In Vivo Monitoring of αvß3-Integrin Expression as Biomarker of Anti-Angiogenic Therapy Effects in Experimental Breast Cancer.

Author

Philipp M Kazmierczak, Andrei Todica, Franz-Josef Gildehaus, Heidrun Hirner-Eppeneder, Matthias Brendel, Ralf S Eschbach, Magdalena Hellmann, Konstantin Nikolaou, Maximilian F Reiser, Hans-Jürgen Wester, Saskia Kropf, Axel Rominger, and Clemens C Cyran

Subjects
Medicine, Science
Abstract

To investigate 68Ga-TRAP-(RGD)3 hybrid imaging for the in vivo monitoring of αvß3-integrin expression as biomarker of anti-angiogenic therapy effects in experimental breast cancer.Human breast cancer (MDA-MB-231) xenografts were implanted orthotopically into the mammary fat pads of n = 25 SCID mice. Transmission/emission scans (53 min to 90 min after i.v. injection of 20 MBq 68Ga-TRAP-(RGD)3) were performed on a dedicated small animal PET before (day 0, baseline) and after (day 7, follow-up) a 1-week therapy with the VEGF antibody bevacizumab or placebo (imaging cohort n = 13; therapy n = 7, control n = 6). The target-to-background ratio (TBR, VOImaxtumor/VOImeanmuscle) served as semiquantitative measure of tumor radiotracer uptake. Unenhanced CT data sets were subsequently acquired for anatomic coregistration and morphology-based tumor response assessments (CT volumetry). The imaging results were validated by multiparametric ex vivo immunohistochemistry (αvß3-integrin, microvascular density-CD31, proliferation-Ki-67, apoptosis-TUNEL) conducted in a dedicated immunohistochemistry cohort (n = 12).68Ga-TRAP-(RGD)3 binding was significantly reduced under VEGF inhibition and decreased in all bevacizumab-treated animals (ΔTBRfollow-up/baseline: therapy -1.07±0.83, control +0.32±1.01, p = 0.022). No intergroup difference in tumor volume development between day 0 and day 7 was observed (Δvolumetherapy 134±77 μL, Δvolumecontrol 132±56 μL, p = 1.000). Immunohistochemistry revealed a significant reduction of αvß3-integrin expression (308±135 vs. 635±325, p = 0.03), microvascular density (CD31, 168±108 vs. 432±70, p = 0.002), proliferation (Ki-67, 5,195±1,002 vs. 7,574±418, p = 0.004) and significantly higher apoptosis (TUNEL, 14,432±1,974 vs. 3,776±1,378, p = 0.002) in the therapy compared to the control group.68Ga-TRAP-(RGD)3 hybrid imaging allows for the in vivo assessment of αvß3-integrin expression as biomarker of anti-angiogenic therapy effects in experimental breast cancer.

Published
2016
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6. Correlation of perfusion MRI and 18F-FDG PET imaging biomarkers for monitoring regorafenib therapy in experimental colon carcinomas with immunohistochemical validation.

Author

Ralf S Eschbach, Wolfgang P Fendler, Philipp M Kazmierczak, Marcus Hacker, Axel Rominger, Janette Carlsen, Heidrun Hirner-Eppeneder, Jessica Schuster, Matthias Moser, Lukas Havla, Moritz J Schneider, Michael Ingrisch, Lukas Spaeth, Maximilian F Reiser, Konstantin Nikolaou, and Clemens C Cyran

Subjects
Medicine, Science
Abstract

OBJECTIVES:To investigate a multimodal, multiparametric perfusion MRI / 18F-fluoro-deoxyglucose-(18F-FDG)-PET imaging protocol for monitoring regorafenib therapy effects on experimental colorectal adenocarcinomas in rats with immunohistochemical validation. MATERIALS AND METHODS:Human colorectal adenocarcinoma xenografts (HT-29) were implanted subcutaneously in n = 17 (n = 10 therapy group; n = 7 control group) female athymic nude rats (Hsd:RH-Foxn1rnu). Animals were imaged at baseline and after a one-week daily treatment protocol with regorafenib (10 mg/kg bodyweight) using a multimodal, multiparametric perfusion MRI/18F-FDG-PET imaging protocol. In perfusion MRI, quantitative parameters of plasma flow (PF, mL/100 mL/min), plasma volume (PV, %) and endothelial permeability-surface area product (PS, mL/100 mL/min) were calculated. In 18F-FDG-PET, tumor-to-background-ratio (TTB) was calculated. Perfusion MRI parameters were correlated with TTB and immunohistochemical assessments of tumor microvascular density (CD-31) and cell proliferation (Ki-67). RESULTS:Regorafenib significantly (p

Published
2015
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7. Detection of very-high-energy γ -ray emission from the colliding wind binary η Car with H.E.S.S

Author

E. O. Angüner, Ramin Marx, M. Panter, U. Katz, G. Heinzelmann, Iryna Lypova, S. Nakashima, Yvonne Becherini, G. Martí-Devesa, Stefan Klepser, H. Yoneda, A. Fiasson, L. Giunti, P. deWilt, J. King, R. Adam, I. Jung-Richardt, James Davies, F. Eichhorn, Michael Punch, Maria Haupt, R. J. Tuffs, Michal Ostrowski, J.-P. Lenain, Stefan Ohm, Łukasz Stawarz, J. F. Glicenstein, Frank M. Rieger, Markus Holler, Michelle Tsirou, C. Levy, S. Pita, S. Colafrancesco, L. Rinchiuso, Q. Remy, Felix Jankowsky, J. Zorn, M.-H. Grondin, Mischa Breuhaus, C. Arcaro, Stefano Gabici, F. Niederwanger, Jacco Vink, Sabrina Casanova, Halim Ashkar, M. Curyło, Stefan Funk, Alicja Wierzcholska, Gavin Rowell, M. Bryan, Felix Aharonian, N. Shafi, R. D. Parsons, H. Ndiyavala, B. van Soelen, B. Rudak, Dmitriy Kostunin, K. Nakashima, Nu. Komin, Natalia Żywucka, M. de Naurois, T. Chand, Jhilik Majumdar, L. Oakes, A. Lemière, Heinrich J. Völk, M. Renaud, R. Rauth, Axel Donath, A. W. Chen, M. Büchele, S. Eschbach, M. Barnard, Marek Jamrozy, J. Bolmont, Gianluca Giavitto, K. Bernlöhr, Helene Sol, V. Poireau, H. Odaka, M. Füßling, Jacek Niemiec, Rafal Moderski, C. Perennes, K. Egberts, Dieter Horns, Olaf Reimer, M. Lemoine-Goumard, J. Dyks, Ruizhi Yang, Francois Brun, Reinhard Schlickeiser, Zorawar Wadiasingh, M. Böttcher, Michael Kreter, S. Chandra, Paolo Marchegiani, P. Vincent, S. J. Fegan, A. Djannati-Ataï, V. Barbosa Martins, S. Raab, L. Dirson, F. Gaté, Kirsty Feijen, S. Bonnefoy, Constantin Steppa, Alexandre Marcowith, M. Zacharias, Rachel Simoni, Masanori Arakawa, Celine Armand, Thomas Murach, Joachim Hahn, T. Vuillaume, A. Schulz, Clemens Hoischen, A. A. Zdziarski, Ullrich Schwanke, V. Joshi, V. Sahakian, A. Carosi, F. Werner, F. Ait Benkhali, E. de Oña Wilhelmi, Anton Dmytriiev, Isak Delberth Davids, S. Schwemmer, Arnaud Mares, Andrea Santangelo, Jim Hinton, Roberta Zanin, C. Trichard, S. Sailer, Dmitry Khangulyan, P. J. Meintjes, Tom Armstrong, Matteo Cerruti, D. A. Sanchez, M. Seglar-Arroyo, P.-O. Petrucci, Johan Bregeon, R. J. White, J. Devin, F. Schüssler, M. Scalici, A. Priyana Noel, Domenico Tiziani, D. Malyshev, Tadayuki Takahashi, A.M. Taylor, Werner Hofmann, Michael Backes, Jonathan Mackey, Victor Doroshenko, Gilles Henri, Heike Prokoph, C. Moore, Q. Piel, Dorit Glawion, Tim Holch, E. Moulin, Tomasz Bulik, S. Caroff, D. Huber, Marion Spir-Jacob, G. Maurin, H. Iwasaki, A.S. Seyffert, Naomi Tsuji, D. Jankowsky, Gerard Fontaine, M. Katsuragawa, Andreas Quirrenbach, Hester Schutte, Riaan Steenkamp, Andreas Specovius, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, L. Mohrmann, C. van Rensburg, Misao Sasaki, D. J. van der Walt, M. Hörbe, T. Tavernier, E. Leser, P. T. O'Brien, B. Khélifi, G. Hermann, Regis Terrier, Carlo Romoli, Christo Venter, Y. A. Gallant, Atreyee Sinha, C. van Eldik, A. Zech, M. Mohamed, Garret Cotter, D. A. Prokhorov, K. Kosack, B. Peyaud, G. Pühlhofer, A. Reimer, Pierre Brun, Jean-Pierre Ernenwein, Johannes Veh, R. Blackwell, E. Ruiz-Velasco, G. Emery, S. Saito, Thomas Bylund, M. Tluczykont, Armelle Jardin-Blicq, Jacques Muller, Samuel Timothy Spencer, H. Abdalla, M. A. Kastendieck, G. Vasileiadis, Włodek Kluźniak, Krzysztof Katarzynski, Catherine Boisson, Christoph Deil, Mohanraj Senniappan, D. Berge, Paul J. Morris, Kleopas Shiningayamwe, Lenka Tomankova, Jason John Watson, V. Marandon, D. Gottschall, Thomas Lohse, G. Lamanna, Alexander von Humboldt Foundation, Southern California Earthquake Center, EGI Foundation, Science and Technology Facilities Council (UK), Australian Research Council, German Research Foundation, Japan Society for the Promotion of Science, University of Amsterdam, Federal Ministry of Education and Research (Germany), Austrian Science Fund, Knut and Alice Wallenberg Foundation, Max Planck Society, National Science Centre (Poland), Centre National de la Recherche Scientifique (France), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), Helmholtz Association, National Commission on Research Science and Technology (Namibia), University of Namibia, Federal Ministry of Education, Science and Research (Austria), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), H.E.S.S., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, H.E.S.S. Collaboration, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)

Subjects
individual: η CarStars: Wolf-Rayet [Stars], Photon, stars: individual: η Car, Astrophysics::High Energy Astrophysical Phenomena, Flux, Cosmic ray, Astrophysics, 01 natural sciences, cosmic rays, 0103 physical sciences, individual: η Car [stars], High Energy Stereoscopic System, 010303 astronomy & astrophysics, Cosmic rays, Colliding-wind binary, Astroparticle physics, Physics, Spectral index, non-thermal [Radiation mechanisms], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], general [Binaries], 010308 nuclear & particles physics, Astronomy and Astrophysics, radiation mechanisms: non-thermal, Wolf-Rayet [stars], binaries: general, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], astroparticle physics, ddc:520, HESS - Abteilung Hinton, stars: Wolf-Rayet, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Stars: individual: η CarStars: Wolf-Rayet, Noise (radio)
Abstract

Aims. Colliding wind binary systems have long been suspected to be high-energy (HE; 100 MeV < E < 100 GeV) {\gamma}-ray emitters. {\eta} Car is the most prominent member of this object class and is confirmed to emit phase-locked HE {\gamma} rays from hundreds of MeV to ~100 GeV energies. This work aims to search for and characterise the very-high-energy (VHE; E >100 GeV) {\gamma}-ray emission from {\eta} Car around the last periastron passage in 2014 with the ground-based High Energy Stereoscopic System (H.E.S.S.). Methods. The region around {\eta} Car was observed with H.E.S.S. between orbital phase p = 0.78 - 1.10, with a closer sampling at p {\approx} 0.95 and p {\approx} 1.10 (assuming a period of 2023 days). Optimised hardware settings as well as adjustments to the data reduction, reconstruction, and signal selection were needed to suppress and take into account the strong, extended, and inhomogeneous night sky background (NSB) in the {\eta} Car field of view. Tailored run-wise Monte-Carlo simulations (RWS) were required to accurately treat the additional noise from NSB photons in the instrument response functions. Results. H.E.S.S. detected VHE {\gamma}-ray emission from the direction of {\eta} Car shortly before and after the minimum in the X-ray light-curve close to periastron. Using the point spread function provided by RWS, the reconstructed signal is point-like and the spectrum is best described by a power law. The overall flux and spectral index in VHE {\gamma} rays agree within statistical and systematic errors before and after periastron. The {\gamma}-ray spectrum extends up to at least ~400 GeV. This implies a maximum magnetic field in a leptonic scenario in the emission region of 0.5 Gauss. No indication for phase-locked flux variations is detected in the H.E.S.S. data., Comment: 9 pages, 4 figures, 3 tables, in press with A&A

Published
2020

8. Resolving the Crab pulsar wind nebula at teraelectronvolt energies

Author

Natalia Żywucka, M. de Naurois, T. Chand, Frank M. Rieger, J. Bolmont, S. Colafrancesco, Ruizhi Yang, W. Kluźniak, S. Eschbach, Jim Hinton, R. Simoni, Dmitry Khangulyan, Christopher J. Moore, G. Fontaine, M. Büchele, D. A. Sanchez, T. Tavernier, L. Mohrmann, Denys Malyshev, J. Veh, S. Klepser, B. Khélifi, H. M. Schutte, C. Perennes, D. Glawion, Christoph Deil, Mohanraj Senniappan, A.A. Zdziarski, A. Djannati-Ataï, Y.A. Gallant, Gavin Rowell, Stefan Funk, T. Takahashi, Gianluca Giavitto, Axel Donath, A. W. Chen, M. Bryan, J. Dyks, D. Zaborov, I. Oya, G. Heinzelmann, K. Shiningayamwe, T. Lohse, Yvonne Becherini, M. Renaud, H. Iwasaki, M. Holler, J.-P. Ernenwein, P. Vincent, R. D. Parsons, G. Emery, H. Odaka, Christo Venter, D. Huber, M. Arakawa, D. Berge, M. Capasso, Matteo Cerruti, Nachiketa Chakraborty, F. Niederwanger, A. Marcowith, A. Zech, E. Leser, Jacco Vink, R. Rauth, Sabrina Casanova, C. Arcaro, I. Jung-Richardt, T. Vuillaume, G. Hermann, D. Gottschall, Werner Hofmann, Regis Terrier, J. Becker Tjus, A. Schulz, Carlo Romoli, M. Panter, M. Seglar-Arroyo, H. Ndiyavala, B. van Soelen, Felix Aharonian, M. Haupt, Lukasz Stawarz, Michael Punch, V. Doroshenko, M. Spir-Jacob, R. Tuffs, R. C. G. Chaves, E. O. Angüner, A. Priyana Noel, L. O'c. Drury, S. Saito, J.F. Glicenstein, D. J. van der Walt, S. Raab, Andreas Quirrenbach, C. Steppa, J.-P. Lenain, N. Shafi, K. Egberts, Robert Wagner, K. Kosack, J. Hahn, Reinhard Schlickeiser, M. Tsirou, G. Vasileiadis, M. Kraus, S. Chandra, S. Nakashima, G. Martí-Devesa, M. Katsuragawa, Ruben Lopez-Coto, M.-H. Grondin, M. Böttcher, R. Blackwell, E. Ruiz-Velasco, L. Dirson, Stefan Ohm, Léa Jouvin, S. Pita, F. Schüssler, P. deWilt, J. King, F. Voisin, Julien Lefaucheur, A. Dmytriiev, R. Moderski, S. Gabici, A. Fiasson, J. Lau, L. Oakes, I.D. Davids, Alison Mitchell, L. Rinchiuso, P.J. Meintjes, Heike Prokoph, Zorawar Wadiasingh, R. J. White, S. Fegan, Dieter Horns, V. Poireau, Monica Barnard, P.-O. Petrucci, H. Abdalla, D. Jankowsky, Q. Piel, C. Stegmann, Nu. Komin, Marek Jamrozy, Catherine Boisson, Helene Sol, Pierre Brun, A.S. Seyffert, A. Carosi, M. Füßling, M.A. Kastendieck, S. Bonnefoy, N. Tsuji, F. Gaté, J. Devin, G. Henri, D. A. Prokhorov, D. Tiziani, C. Hoischen, Ullrich Schwanke, A. Specovius, R. Steenkamp, A. Reimer, J. Bregeon, Francois Brun, B. Condon, Michael Backes, H. Yoneda, Tim Holch, M. Tluczykont, E. Moulin, Tomasz Bulik, T. Bylund, A. Jacholkowska, S. Caroff, Celine Armand, F. Jankowsky, Stefan Wagner, Yasunobu Uchiyama, C. van Rensburg, M. Zacharias, C. Trichard, F. Ait Benkhali, Manami Sasaki, S. Schwemmer, Andrea Santangelo, A. Ziegler, G. Maurin, A. Wierzcholska, C. Mariaud, Jacek Niemiec, Olaf Reimer, Thomas Murach, A. Lemière, M. Lemoine-Goumard, I. Shilon, Heinrich J. Völk, R. Marx, P. Bordas, I. Lypova, G. Lamanna, J. Zorn, U. Katz, J.-P. Tavernet, B. Rudak, V. Marandon, K. Katarzyński, A.M. Taylor, V. Sahakian, M. Mohamed, M. Ostrowski, Konrad Bernlöhr, B. Peyaud, G. Pühlhofer, R. Zanin, P. T. O'Brien, Atreyee Sinha, C. van Eldik, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, H.E.S.S., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), European Commission, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Armagh Observatory, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 26403366 - Ndiyavala, Hambeleleni, 10060499 - Van der Walt, Diederick Johannes, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 29092086 - Zacharias, Michael, and Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
010504 meteorology & atmospheric sciences, Electromagnetic spectrum, electron: relativistic, magnetic field, Astrophysics, positron: energy, 01 natural sciences, 7. Clean energy, Pulsar wind nebula, particle: acceleration, Raigs gamma, Astrophysics::Solar and Stellar Astrophysics, HESS - Abteilung Hofmann, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, pulsar, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, [PHYS]Physics [physics], Nebula, radio wave, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 4. Education, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], photon, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, High-energy astrophysics, Particle astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Camps magnètics, accelerator, High-energy astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, gap, X-ray, energy loss: rotation, Pulsar, 0103 physical sciences, synchrotron, Astrophysics::Galaxy Astrophysics, gamma ray: energy, 0105 earth and related environmental sciences, Crab Pulsar, Gamma rays, Astronomy and Astrophysics, Crab Nebula, electromagnetic, gamma ray: VHE, [SDU]Sciences of the Universe [physics], Magnetic fields, ddc:520, Physics::Accelerator Physics
Abstract

arXiv:1909.09494v2, H.E.S.S. Collaboration: et al., The support of the Namibian authorities and of the University of Namibia in facilitating the construction and operation of H.E.S.S. is gratefully acknowledged, as is the support by the German Ministry for Education and Research (BMBF), the Max Planck Society, the German Research Foundation (DFG), the Helmholtz Association, the Alexander von Humboldt Foundation, the French Ministry of Higher Education, Research and Innovation, the Centre National de la Recherche Scientifique (CNRS/IN2P3 and CNRS/INSU), the Commissariat à l’énergie atomique et aux énergies alternatives (CEA), the UK Science and Technology Facilities Council (STFC), the Knut and Alice Wallenberg Foundation, the National Science Centre, Poland (grant number 2016/22/M/ST9/00382), the South African Department of Science and Technology and the National Research Foundation, the University of Namibia, the National Commission on Research, Science and Technology of Namibia (NCRST), the Austrian Federal Ministry of Education, Science and Research and the Austrian Science Fund (FWF), the Australian Research Council (ARC), the Japan Society for the Promotion of Science and the University of Amsterdam. We appreciate the excellent work of the technical support staff in Berlin, Zeuthen, Heidelberg, Palaiseau, Paris, Saclay, Tübingen and Namibia in the construction and operation of the equipment. This work benefited from services provided by the H.E.S.S. Virtual Organisation, supported by the national resource providers of the EGI Federation. R.C.G.C. was funded by EU FP7 Marie Curie (grant agreement number PIEF-GA-2012-332350).

Published
2020

9. Trigger performance verification of the FlashCam prototype camera

Author

F. Garrecht, S. Steiner, D. Wolf, Giacomo Principe, U. Straumann, Robert Lahmann, S. Bernhard, Thomas Kihm, I. Jung, Sebastian Diebold, F. Canelli, D. Florin, S. Pürckhauer, Olaf Reimer, C. Kalkuhl, O. Kalekin, M. Biegger, F. Eisenkolb, T. Schwab, M. Pfeifer, C. Tenzer, S. Eschbach, C. Föhr, A. Gadola, G. Pühlhofer, A. Vollhardt, Andrea Santangelo, Simon Sailer, C. Bauer, M. Barcelo, M. Scalici, F. Werner, M. Capasso, G. Hermann, Thomas Schanz, and Stefan Funk

Subjects
Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, business.industry, Monte Carlo method, Night sky, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Parameter space, Continuous light, Cherenkov Telescope Array, 01 natural sciences, Front and back ends, Data acquisition, Optics, 0103 physical sciences, business, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Instrumentation, Intensity (heat transfer)
Abstract

FlashCam is a camera proposed for the medium-sized telescopes of the Cherenkov Telescope Array (CTA). We compare camera trigger rates obtained from measurements with the camera prototype in the laboratory and Monte-Carlo simulations, when scanning the parameter space of the fully-digital trigger logic and the intensity of a continuous light source mimicking the night sky background (NSB) during on-site operation. The comparisons of the measured data results to the Monte-Carlo simulations are used to verify the FlashCam trigger logic and the expected trigger performance., 14th Pisa Meeting on Advanced Detectors

Published
2019

10. H.E.S.S. and Suzaku observations of the Vela X pulsar wind nebula

Author

P. deWilt, J. King, C. Mariaud, J. Zorn, J. Dyks, Matteo Cerruti, Nachiketa Chakraborty, Jacek Niemiec, D. J. van der Walt, Florian Gaté, R. C. G. Chaves, E. O. Angüner, G. Lamanna, S. Nakashima, Olaf Reimer, H. Yoneda, Werner Hofmann, J. Lau, Michelle Tsirou, N. Shafi, Natalia Żywucka, M. de Naurois, Michael Punch, L. Rinchiuso, Michael Backes, Sami Caroff, Thomas Murach, D. A. Prokhorov, K. Kosack, Konrad Bernlöhr, M.-H. Grondin, G. Emery, Stefan Ohm, S. Saito, Axel Donath, A. W. Chen, F. Niederwanger, Markus Böttcher, M. Seglar-Arroyo, S. Pita, G. Pühlhofer, Krzysztof Katarzynski, Tim Holch, Ramin Marx, M. Panter, U. Katz, Jacco Vink, Catherine Boisson, A. Reimer, Marek Jamrozy, Ruizhi Yang, Stefano Gabici, Naomi Tsuji, Emmanuel Moulin, Pierre Brun, V. Marandon, I. Oya, M. Kraus, Helene Sol, I. Shilon, Sabrina Casanova, M. Büchele, F. Ait Benkhali, Anton Dmytriiev, Jean-Pierre Ernenwein, A. Fiasson, Manami Sasaki, L. Oakes, C. Perennes, S. Schwemmer, Andrea Santangelo, J. Bolmont, S. J. Fegan, A. Djannati-Ataï, R. D. Parsons, V. Poireau, Dieter Horns, D. Jankowsky, Johannes Veh, M. Tluczykont, F. Schüssler, A. Schulz, S. Bonnefoy, H. Abdalla, M. A. Kastendieck, T. Chand, G. Vasileiadis, Constantin Steppa, E. de Oña Wilhelmi, Isak Delberth Davids, M. Mohamed, E. Leser, Włodek Kluźniak, Roberta Zanin, Y. A. Gallant, Clemens Hoischen, A. A. Zdziarski, Nu. Komin, Iryna Lypova, Gianluca Giavitto, Heinrich J. Völk, Yvonne Becherini, P. T. O'Brien, Ullrich Schwanke, M. Renaud, B. van Soelen, B. Condon, Riaan Steenkamp, B. Khélifi, G. Hermann, Regis Terrier, Rachel Simoni, Carlo Romoli, Christoph Deil, B. Rudak, D. Gottschall, Anne Lemiere, Justine Devin, Mohanraj Senniappan, A. Carosi, K. Egberts, Masanori Arakawa, Pascal Vincent, H. Odaka, Frank M. Rieger, R. Blackwell, E. Ruiz-Velasco, Thomas Bylund, S. Raab, I. Jung-Richardt, Tadayuki Takahashi, A. S. Seyffert, Atreyee Sinha, Kirsty Feijen, C. van Eldik, Victor Doroshenko, Markus Holler, G. Heinzelmann, Felix Jankowsky, D. Berge, M. Füßling, N. Maxted, R. J. Tuffs, Felix Aharonian, G. Martí-Devesa, H. Prokoph, Jim Hinton, Dmitry Khangulyan, Alison Mitchell, S. Eschbach, Thomas Lohse, H. Iwasaki, L. Tibaldo, J.-P. Tavernet, Kleopas Shiningayamwe, F. Voisin, Reinhard Schlickeiser, S. Colafrancesco, S. Chandra, M. Capasso, Michal Ostrowski, V. Sahakian, J.-P. Lenain, Dmitriy Kostunin, L. Dirson, R. J. White, R. Rauth, Gilles Maurin, Zorawar Wadiasingh, Stefan Funk, Alicja Wierzcholska, Domenico Tiziani, D. Malyshev, Monica Barnard, Thomas Tavernier, B. Peyaud, Maria Haupt, Hester Schutte, L. O'c. Drury, A.M. Taylor, Rafal Moderski, Andreas Specovius, Christo Venter, C. Trichard, P. J. Meintjes, A. Zech, David Sánchez, A. Ziegler, Léa Jouvin, Marion Spir-Jacob, D. Huber, C. Arcaro, Gavin Rowell, M. Bryan, D. Zaborov, C. Moore, Dorit Glawion, Tomasz Bulik, M. Katsuragawa, A. Jacholkowska, Andreas Quirrenbach, Michael Zacharias, Joachim Hahn, P.-O. Petrucci, Stefan Klepser, Łukasz Stawarz, Gilles Henri, Q. Piel, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, L. Mohrmann, C. van Rensburg, T. Vuillaume, J. F. Glicenstein, A. Priyana Noel, Francois Brun, J. Bregeon, Celine Armand, Ruben Lopez-Coto, M. Lemoine-Goumard, Gilles Fontaine, A. Marcowith, Hambeleleni Ndiyavala, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), H.E.S.S. Collaboration, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), API Other Research (FNWI), Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, M., 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 31125417 - Chandra, Sunil, 26403366 - Ndiyavala, Hambeleleni, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, 30366755 - Chand, T.B., 34208968 - Zywucka-Hejzner, Natalia, 10060499 - Van der Walt, Diederick Johannes, 28644743 - Backes, Michael, 30366755 - Chand, Tej B., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Camps magnètics, Astrophysics::High Energy Astrophysical Phenomena, Synchrotron radiation, FOS: Physical sciences, Cosmic ray, Astrophysics, Vela, gamma rays: stars, 01 natural sciences, 7. Clean energy, Pulsar wind nebula, outflows, Relativistic particle, Raigs gamma, Pulsar, 0103 physical sciences, ddc:530, winds, outflows [stars], 010303 astronomy & astrophysics, individual: PSR B0833-45 [pulsars], Astrophysics::Galaxy Astrophysics, acceleration of particles, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, Computer Science::Information Retrieval, Gamma rays, Institut für Physik und Astronomie, Astronomy and Astrophysics, radiation mechanisms: non-thermal, non-thermal [radiation mechanisms], stars [gamma rays], pulsars: individual: PSR B0833-45, Crab Nebula, 13. Climate action, Space and Planetary Science, stars: winds, Magnetic fields, ddc:520, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Heliosphere
Abstract

Pulsar Wind Nebulae (PWNe) represent the most prominent population of Galactic very-high-energy gamma-ray sources and are thought to be an efficient source of leptonic cosmic rays. Vela X is a nearby middle-aged PWN, which shows bright X-ray and TeV gamma-ray emission toward an elongated structure called the cocoon. Since TeV emission is likely inverse-Compton emission of electrons while X-ray emission is synchrotron radiation of the same electrons, we aim to derive the properties of the relativistic particles and of magnetic fields with minimal modelling. We use data from the Suzaku XIS to derive the spectra from three compact regions in Vela X covering distances from 0.3 pc to 4 pc from the pulsar along the cocoon. We obtain gamma-ray spectra of the same regions from H.E.S.S. observations and fit a radiative model to the multi-wavelength spectra. The TeV electron spectra and magnetic field strengths are consistent within the uncertainties for the three regions, with energy densities of the order $10^{-12}\rm\,erg\,cm^{-3}$. The data indicate the presence of a cutoff in the electron spectrum at energies of $\sim$100 TeV and a magnetic field strength of $\sim$$6\,\rm\mu G$. Constraints on the presence of turbulent magnetic fields are weak. The pressure of TeV electrons and magnetic fields in the cocoon is dynamically negligible, requiring the presence of another dominant pressure component. Sub-TeV electrons cannot account completely for the missing pressure, that may be provided either by relativistic ions or from mixing of the ejecta with the pulsar wind. The electron spectra are consistent with expectations from transport scenarios dominated either by advection via the reverse shock or by diffusion. Constraints on turbulent magnetic fields and the shape of the electron cutoff can be improved by spectral measurements in the energy range $\gtrsim 10\rm\,keV$. (abridged), Comment: Accepted for publication in A&A

Published
2019

11. Analysis of the H.E.S.S. public data release with ctools

Author

Andreas Specovius, Jürgen Knödlseder, Maria Haupt, Andreas Ziegler, Leonardo Di Venere, Josh Cardenzana, Thierry Louge, Francois Brun, Domenico Tiziani, Rolf Bühler, N. Kelley-Hoskins, S. Eschbach, S. Bonnefoy, Luigi Tibaldo, Pierrick Martin, Michael Mayer, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Erlangen Centre for Astroparticle Physics (ECAP), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Deutsches Elektronen-Synchrotron [Zeuthen] (DESY), Helmholtz-Gemeinschaft = Helmholtz Association, Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Computer science, FOS: Physical sciences, 01 natural sciences, law.invention, law, 0103 physical sciences, MAGIC (telescope), 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, Remote sensing, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, Event (computing), [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astronomy and Astrophysics, VERITAS, Cherenkov Telescope Array, methods: data analysis, Sextant (astronomical), Crab Nebula, astroparticle physics, Space and Planetary Science, ddc:520, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The ctools open-source software package was developed for the scientific analysis of astronomical data from Imaging Air Cherenkov Telescopes (IACTs), such as H.E.S.S., VERITAS, MAGIC, and the future Cherenkov Telescope Array (CTA). To date, the software has been mainly tested using simulated CTA data; however, upon the public release of a small set of H.E.S.S. observations of the Crab nebula, MSH 15-52, RX J1713.7-3946, and PKS 2155-304 validation using real data is now possible. We analysed the data of the H.E.S.S. public data release using ctools version 1.6 and compared our results to those published by the H.E.S.S. Collaboration for the respective sources. We developed a parametric background model that satisfactorily describes the expected background rate as a function of reconstructed energy and direction for each observation. We used that model, and tested all analysis methods that are supported by ctools, including novel unbinned and joint or stacked binned analyses of the measured event energies and reconstructed directions, and classical On-Off analysis methods that are comparable to those used by the H.E.S.S. Collaboration. For all analysis methods, we found a good agreement between the ctools results and the H.E.S.S. Collaboration publications considering that they are not always directly comparable due to differences in the datatsets and event processing software. We also performed a joint analysis of H.E.S.S. and Fermi-LAT data of the Crab nebula, illustrating the multi-wavelength capacity of ctools. The joint Crab nebula spectrum is compatible with published literature values within the systematic uncertainties. We conclude that the ctools software is mature for the analysis of data from existing IACTs, as well as from the upcoming CTA., Comment: 34 pages, 47 figures

Published
2019
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12. A very-high-energy component deep in the $\gamma$-ray burst afterglow

Author

H. Abdalla, R. Adam, F. Aharonian, F. Ait Benkhali, E. O. Angüner, M. Arakawa, C. Arcaro, C. Armand, H. Ashkar, M. Backes, V. Barbosa Martins, M. Barnard, Y. Becherini, D. Berge, K. Bernlöhr, E. Bissaldi, R. Blackwell, M. Böttcher, C. Boisson, J. Bolmont, S. Bonnefoy, J. Bregeon, M. Breuhaus, F. Brun, P. Brun, M. Bryan, M. Büchele, T. Bulik, T. Bylund, M. Capasso, S. Caroff, A. Carosi, S. Casanova, M. Cerruti, T. Chand, S. Chandra, A. Chen, S. Colafrancesco, M. Curyło, I. D. Davids, C. Deil, J. Devin, P. deWilt, L. Dirson, A. Djannati-Ataï, A. Dmytriiev, A. Donath, V. Doroshenko, J. Dyks, K. Egberts, G. Emery, J.-P. Ernenwein, S. Eschbach, K. Feijen, S. Fegan, A. Fiasson, G. Fontaine, S. Funk, M. Füßling, S. Gabici, Y. A. Gallant, F. Gaté, G. Giavitto, L. Giunti, D. Glawion, J. F. Glicenstein, D. Gottschall, M.-H. Grondin, J. Hahn, M. Haupt, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, W. Hofmann, C. Hoischen, T. L. Holch, M. Holler, D. Horns, D. Huber, H. Iwasaki, M. Jamrozy, D. Jankowsky, F. Jankowsky, A. Jardin-Blicq, I. Jung-Richardt, M. A. Kastendieck, K. Katarzyński, M. Katsuragawa, U. Katz, D. Khangulyan, B. Khélifi, J. King, S. Klepser, W. Kluźniak, Nu. Komin, K. Kosack, D. Kostunin, M. Kreter, G. Lamanna, A. Lemière, M. Lemoine-Goumard, J.-P. Lenain, E. Leser, C. Levy, T. Lohse, I. Lypova, J. Mackey, J. Majumdar, D. Malyshev, V. Marandon, A. Marcowith, A. Mares, C. Mariaud, G. Martí-Devesa, R. Marx, G. Maurin, P. J. Meintjes, A. M. W. Mitchell, R. Moderski, M. Mohamed, L. Mohrmann, C. Moore, E. Moulin, J. Muller, T. Murach, S. Nakashima, M. de Naurois, H. Ndiyavala, F. Niederwanger, J. Niemiec, L. Oakes, P. O’Brien, H. Odaka, S. Ohm, E. de Ona Wilhelmi, M. Ostrowski, I. Oya, M. Panter, R. D. Parsons, C. Perennes, P.-O. Petrucci, B. Peyaud, Q. Piel, S. Pita, V. Poireau, A. Priyana Noel, D. A. Prokhorov, H. Prokoph, G. Pühlhofer, M. Punch, A. Quirrenbach, S. Raab, R. Rauth, A. Reimer, O. Reimer, Q. Remy, M. Renaud, F. Rieger, L. Rinchiuso, C. Romoli, G. Rowell, B. Rudak, E. Ruiz-Velasco, V. Sahakian, S. Sailer, S. Saito, D. A. Sanchez, A. Santangelo, M. Sasaki, R. Schlickeiser, F. Schüssler, A. Schulz, H. M. Schutte, U. Schwanke, S. Schwemmer, M. Seglar-Arroyo, M. Senniappan, A. S. Seyffert, N. Shafi, K. Shiningayamwe, R. Simoni, A. Sinha, H. Sol, A. Specovius, M. Spir-Jacob, Ł. Stawarz, R. Steenkamp, C. Stegmann, C. Steppa, T. Takahashi, T. Tavernier, A. M. Taylor, R. Terrier, D. Tiziani, M. Tluczykont, C. Trichard, M. Tsirou, N. Tsuji, R. Tuffs, Y. Uchiyama, D. J. van der Walt, C. van Eldik, C. van Rensburg, B. van Soelen, G. Vasileiadis, J. Veh, C. Venter, P. Vincent, J. Vink, H. J. Völk, T. Vuillaume, Z. Wadiasingh, S. J. Wagner, R. White, A. Wierzcholska, R. Yang, H. Yoneda, M. Zacharias, R. Zanin, A. A. Zdziarski, A. Zech, A. Ziegler, J. Zorn, N. Żywucka, F. de Palma, M. Axelsson, O. J. Roberts, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Abdalla, H., Adam, R., Aharonian, F., Ait Benkhali, F., Anguner, E. O., Arakawa, M., Arcaro, C., Armand, C., Ashkar, H., Backes, M., Barbosa Martins, V., Barnard, M., Becherini, Y., Berge, D., Bernlohr, K., Bissaldi, E., Blackwell, R., Bottcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Buchele, M., Bulik, T., Bylund, T., Capasso, M., Caroff, S., Carosi, A., Casanova, S., Cerruti, M., Chand, T., Chandra, S., Chen, A., Colafrancesco, S., Curylo, M., Davids, I. D., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Emery, G., Ernenwein, J. -P., Eschbach, S., Feijen, K., Fegan, S., Fiasson, A., Fontaine, G., Funk, S., Fussling, M., Gabici, S., Gallant, Y. A., Gate, F., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Heinzelmann, G., Henri, G., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horns, D., Huber, D., Iwasaki, H., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Jung-Richardt, I., Kastendieck, M. A., Katarzynski, K., Katsuragawa, M., Katz, U., Khangulyan, D., Khelifi, B., King, J., Klepser, S., Kluzniak, W., Komin, N., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Leser, E., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marcowith, A., Mares, A., Mariaud, C., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Moore, C., Moulin, E., Muller, J., Murach, T., Nakashima, S., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., de Ona Wilhelmi, E., Ostrowski, M., Oya, I., Panter, M., Parsons, R. D., Perennes, C., Petrucci, P. -O., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Priyana Noel, A., Prokhorov, D. A., Prokoph, H., Puhlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Saito, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Schlickeiser, R., Schussler, F., Schulz, A., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spir-Jacob, M., Stawarz, L., Steenkamp, R., Stegmann, C., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Trichard, C., Tsirou, M., Tsuji, N., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Volk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., White, R., Wierzcholska, A., Yang, R., Yoneda, H., Zacharias, M., Zanin, R., Zdziarski, A. A., Zech, A., Ziegler, A., Zorn, J., Zywucka, N., de Palma, F., Axelsson, M., Roberts, O. J., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 26403366 - Ndiyavala, Hambeleleni, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 10060499 - Van der Walt, Diederick Johannes, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, 34208968 - Zywucka-Hejzner, Natalia, 33379009 - Kreter, Michael, Faculty of Science, and High Energy Astrophys. & Astropart. Phys (API, FNWI)

Subjects
electron, Brightness, Photon, Astrophysics::High Energy Astrophysical Phenomena, brightness, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Radiation, gamma ray: burst, 7. Clean energy, 01 natural sciences, VHE, Transient astrophysical phenomena, 0103 physical sciences, synchrotron, ddc:530, 010303 astronomy & astrophysics, X-ray: flux, Astrophysics::Galaxy Astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Range (particle radiation), Multidisciplinary, 010308 nuclear & particles physics, particle: energy, photon, Gamma ray, Time-domain astronomy, Institut für Physik und Astronomie, Afterglow, High-energy astrophysics, Automatic Keywords, gamma ray: UHE, Orders of magnitude (time), 13. Climate action, Gamma-ray burst, Particle astrophysics, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

Gamma-ray bursts (GRBs) are brief flashes of gamma rays, considered to be the most energetic explosive phenomena in the Universe. The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow -- produced by the interaction between the ejected matter and the circumburst medium -- slows down, and a gradual decrease in brightness is observed. GRBs typically emit most of their energy via gamma-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments. However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elussive. Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow -ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies., Comment: Preprint version of Nature paper. Contacts: E.Ruiz-Velasco, F. Aharonian, E.Bissaldi, C.Hoischen, R.D Parsons, Q.Piel, A.Taylor, D.Khangulyan

Published
2019

13. Publisher Correction: Resolving acceleration to very high energies along the jet of Centaurus A

Author

T. Bulik, Stefan Klepser, Axel Donath, A. W. Chen, Seb. Funk, Nukri Komin, Matteo Cerruti, D. Berge, F. Schüssler, Florian Gaté, D. Gottschall, Anne Lemiere, Iryna Lypova, Yvonne Becherini, Kleopas Shiningayamwe, S. Raab, Kirsty Feijen, Michael Punch, E. O. Angüner, Werner Hofmann, Riaan Steenkamp, Gilles Fontaine, H. Iwasaki, M. Seglar-Arroyo, A. Carosi, K. Egberts, S. Nakashima, D. Khangulyan, W. Kluźniak, Michael Backes, Rachel Simoni, Thomas Lohse, D.A. Prokhorov, M. Kraus, D. Jankowsky, A. S. Seyffert, Francois Brun, Masanori Arakawa, R. Blackwell, Ramin Marx, M. Panter, U. Katz, Markus Böttcher, Thomas Bylund, H. Yoneda, L. B. Oakes, Tim Holch, C. Mariaud, Dieter Horns, Jim Hinton, M. Füßling, Jacques Muller, J. Bregeon, Gavin Rowell, Clemens Hoischen, A. A. Zdziarski, F. Ait Benkhali, Anton Dmytriiev, Naomi Tsuji, S. Schwemmer, J. Zorn, M. Bryan, Celine Armand, M. Büchele, H. M. Schutte, M. Lemoine-Goumard, C. Perennes, Edna Ruiz-Velasco, G. Martí-Devesa, Gilles Henri, Q. Piel, Dmitriy Kostunin, Stefan Ohm, Andrea Santangelo, M.-H. Grondin, G. Emery, G. Lamanna, Jacek Niemiec, R. Rauth, D. J. van der Walt, Zorawar Wadiasingh, Olaf Reimer, J. Lau, P. T. O'Brien, M. Katsuragawa, Arnaud Mares, S. J. Fegan, A. Djannati-Ataï, S. Pita, Stefano Gabici, Thomas Tavernier, Monica Barnard, C. Boisson, J. Dyks, G. Heinzelmann, P.-O. Petrucci, R. D. Parsons, Thomas Murach, I. Jung-Richardt, Sami Caroff, J. Vink, Gianluca Giavitto, J.-P. Lenain, Regis Terrier, Krzysztof Katarzynski, M. Capasso, T. Chand, V. Barbosa Martins, Jonathan Mackey, Markus Holler, Q. Remy, E. Leser, Andreas Quirrenbach, Felix Jankowsky, Armelle Jardin-Blicq, B. Peyaud, Shun Saito, M. Ostrowski, N. Shafi, Pierre Brun, Natalia Żywucka, Felix Aharonian, U. Schwanke, B. Khélifi, G. Hermann, J. Bolmont, Alicja Wierzcholska, Jean-Pierre Ernenwein, C. Arcaro, R. White, Atreyee Sinha, V. Marandon, H. Odaka, C. van Eldik, Christian Stegmann, Domenico Tiziani, Alison Mitchell, S. Eschbach, Dorit Glawion, Johannes Veh, M. de Naurois, E. Moulin, Reinhard Schlickeiser, L. Mohrmann, C. van Rensburg, P. deWilt, M. Tluczykont, J. King, Misao Sasaki, S. Chandra, V. Sahakian, Y. A. Gallant, T. Vuillaume, Jhilik Majumdar, Justine Devin, K. Kosack, Pascal Vincent, Joachim Hahn, M. Zacharias, Konrad Bernlöhr, L. Dirson, G. Pühlhofer, Michelle Tsirou, R. J. Tuffs, Ł. Stawarz, Ruizhi Yang, H. Prokoph, Christoph Deil, J. F. Glicenstein, A. Priyana Noel, L. Rinchiuso, D. Huber, A. Reimer, Mohanraj Senniappan, Mischa Breuhaus, S. Bonnefoy, Constantin Steppa, A. Schulz, I. Oya, E. de Oña Wilhelmi, Isak Delberth Davids, A. Fiasson, V. Poireau, Roberta Zanin, H. Abdalla, M. A. Kastendieck, S. J. Wagner, G. Vasileiadis, M. Mohamed, Marek Jamrozy, Tadayuki Takahashi, Victor Doroshenko, D. Malyshev, Helene Sol, Christo Venter, R. Moderski, A. Zech, David Sánchez, Andreas Specovius, Christopher J. Moore, Y. Uchiyama, L. O'c. Drury, A.M. Taylor, A. Marcowith, Hambeleleni Ndiyavala, Heinrich J. Völk, M. Renaud, R. Adam, Gilles Maurin, Halim Ashkar, B. van Soelen, B. Rudak, Frank M. Rieger, F. Voisin, C. Levy, S. Colafrancesco, F. Niederwanger, Sabrina Casanova, M. Curyło, C. Trichard, P. J. Meintjes, A. Ziegler, Maria Haupt, C. Romoli, and Marion Spir-Jacob

Subjects
Physics, Acceleration, Jet (fluid), Multidisciplinary, Centaurus A, Astrophysics
Published
2020

14. VHE γ-ray discovery and multi-wavelength study of the blazar 1ES 2322-409

Author

M. Zacharias, Marek Jamrozy, Jim Hinton, A. Schulz, R. Tuffs, R. Simoni, Dmitry Khangulyan, D. A. Sanchez, Helene Sol, H. Ndiyavala, S. Bernhard, J. Devin, M. Böttcher, F. Ait Benkhali, S. Eschbach, C. Stegmann, Nu. Komin, M. Holler, B. van Soelen, Gerd Puehlhofer, F. Jankowsky, J. Veh, D. J. van der Walt, M. Fuessling, M. Lemoine-Goumard, M.A. Kastendieck, S. Bonnefoy, Axel Donath, A. W. Chen, I. Shilon, T. Tavernier, G. Emery, Matteo Cerruti, Michael Punch, M. Spir-Jacob, Manami Sasaki, S. Schwemmer, Andrea Santangelo, J. Lau, B. Peyaud, E. Leser, G. Hermann, Regis Terrier, Carlo Romoli, F. Gaté, R. Rauth, Fabian Schüssler, A. Jacholkowska, M. de Naurois, A. Woernlein, P. Bordas, D. A. Prokhorov, R. Marx, Werner Hofmann, Felix Spanier, Catherine Boisson, Stefan Funk, R. Zanin, R. C. G. Chaves, E. O. Angüner, D. Tiziani, I. Lypova, Stefan Wagner, Yasunobu Uchiyama, Christo Venter, D. Berge, D. Huber, D. Gottschall, P. T. O'Brien, Ullrich Schwanke, C. Perennes, Ruizhi Yang, S. Gabici, C. van Rensburg, J.F. Glicenstein, A. Marcowith, C. Hoischen, Wlodek Kluzniak, S. Saito, G. Fontaine, A. Zech, G. Maurin, K. Kosack, Jacek Niemiec, M. Lorentz, J. Becker Tjus, P.-O. Petrucci, L. Mohrmann, R. Steenkamp, A. Djannati-Ataï, S. Nakashima, Robert Wagner, J. Lefaucheur, A. Wierzcholska, Atreyee Sinha, C. van Eldik, C. Mariaud, A.M. Taylor, Aion Viana, S. Klepser, Olaf Reimer, R. J. White, G. Martí-Devesa, J.-P. Lenain, N. Shafi, Pierre Brun, T. Takahashi, Michael Backes, Gianluca Giavitto, T. Garrigoux, R. Blackwell, J. Hahn, N. Zywucka, Dieter Horns, I.D. Davids, S. Raab, Thomas Murach, E. Ruiz-Velasco, K. Egberts, Tim Holch, Reinhard Schlickeiser, M. Tsirou, G. Henri, A. M. W. Mitche, M. Mohamed, G. Vasileiadis, M. Ostrowski, H. Odaka, S. Chandra, P.J. Meintjes, S. Fegan, Marco Padovani, T. Lohse, A. Reimer, J. Bregeon, M. Renaud, H. Iwasaki, A. Carosi, R. R. Kruger, A. Lemière, H. Abdalla, B. Khélifi, Denys Malyshev, Nachiketa Chakraborty, K. Bernloehr, Stefan Ohm, S. Caroff, S. Pita, E. Moulin, Tomasz Bulik, D. Glawion, M. Panter, T. Bylund, Mohanraj Senniappan, A. Fiasson, L. Dirson, V. Poireau, L. Oakes, I. Sushch, A.A. Zdziarski, I. Jung-Richardt, Yvonne Becherini, D. Kerszberg, Masanori Arakawa, I. Oya, G. Heinzelmann, Felix Aharonian, L. Tibaldo, Zorawar Wadiasingh, B. Condon, Monica Barnard, F. Zefi, M. Buechele, M. Capasso, S. Krakau, V. Sahakian, D. Jankowsky, Q. Piel, J. Zorn, U. Katz, A.S. Seyffert, J.-P. Tavernet, P. Vincent, G. Lamanna, T. Vuillaume, P. deWilt, M. Seglar-Arroyo, J. King, B. Rudak, A. Priyana Noel, A. Dmytriiev, R. Moderski, V. Marandon, K. Katarzyński, L. Rinchiuso, L. Jouvin, M. Katsuragawa, C. Arcaro, M. Kraus, A. Specovius, Francois Brun, M. Tluczykont, Celine Armand, C. Steppa, M. Arrieta, Heike Prokoph, M. Haupt, Lukasz Stawarz, J. Dyks, K. Shiningayamwe, Andreas Quirrenbach, N. Tsuji, C. Trichard, J.-P. Ernenwein, R. D. Parsons, A. Ziegler, L. O. 'C. Drury, Ruben Lopez-Coto, M.-H. Grondin, P. Wagner, C. Dei, Y.A. Gallant, Gavin Rowell, M. Bryan, D. Zaborov, F. Niederwanger, Jacco Vink, Sabrina Casanova, H. J. Voelk, Frank M. Rieger, F. Voisin, J. Bolmont, S. Colafrancesco, Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Collège de France (CdF), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique (ex SAP) (DAP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), H.E.S.S., H.E.S.S. Collaboration, 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 31125417 - Chandra, Sunil, 26909995 - Garrigoux, Tania, 11749903 - Krüger, Petrus Paulus, 26403366 - Ndiyavala, Hambeleleni, 20126999 - Seyffert, Albertus Stefanus, 25161814 - Spanier, Felix Alexander, 24922986 - Sushch, Iurii, 10060499 - Van der Walt, Diederick Johannes, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Collège de France (CdF (institution)), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Faculty of Science, and High Energy Astrophys. & Astropart. Phys (API, FNWI)

Subjects
gamma-rays: galaxies, principal component analysis, Energy flux, Astrophysics, 01 natural sciences, pixel, HESS, ultraviolet, optical, energy: flux, HESS - Abteilung Hofmann, photon: flux, 010303 astronomy & astrophysics, model: leptonic, Physics, radio wave, density, active, [Galaxies], Gamma ray, galaxies [Gamma-rays], individual: 1ES 2322-409 [BL Lacertae objects], active [galaxies], infrared, Spectral energy distribution, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::High Energy Astrophysical Phenomena, galaxies: active, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: energy spectrum, GLAST, blazar, X-ray, 0103 physical sciences, Blazar, Astroparticle physics, non-thermal [Radiation mechanisms], synchrotron radiation, background, 010308 nuclear & particles physics, Institut für Physik und Astronomie, Astronomy and Astrophysics, radiation mechanisms: non-thermal, redshift, proton synchrotron, MAGIC, Redshift, Crab Nebula, gamma ray: VHE, Space and Planetary Science, spectral, ddc:520, High Energy Physics::Experiment, BL Lacertae objects: individual: 1ES 2322−409, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract

著者人数: H.E.S.S. Collaboration 233名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 桂川, 美穂; 中島, 真也; 小高, 裕和; 高橋, 忠幸), Number of authors: H.E.S.S. Collaboration 233 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Katsuragawa, Miho; Nakashima, Shinya; Odaka, Hirokazu; Takahashi, Tadayuki), Accepted: 2018-09-29, 資料番号: SA1180422000

Published
2018

15. Identification and characterization of myocardial metastases in neuroendocrine tumor patients using 68Ga-DOTATATE PET-CT

Author

Jens Ricke, Robert Stahl, Peter Bartenstein, Christoph J. Auernhammer, Clemens C. Cyran, Christine Spitzweg, Axel Rominger, Wolfgang G. Kunz, Ralf S. Eschbach, and Philipp M. Kazmierczak

Subjects
Adult, Male, lcsh:Medical physics. Medical radiology. Nuclear medicine, lcsh:R895-920, 030204 cardiovascular system & hematology, Neuroendocrine tumors, lcsh:RC254-282, Pericardial effusion, Heart Neoplasms, Multidetector computed tomography, 03 medical and health sciences, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, Organometallic Compounds, medicine, Humans, Radiology, Nuclear Medicine and imaging, Stage (cooking), Aged, PET-CT, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Myocardium, Cancer, General Medicine, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Confidence interval, Exact test, Oncology, Positron emission tomography, 030220 oncology & carcinogenesis, Female, Positron-emission tomography, Nuclear medicine, business
Abstract

Background Focal 68Ga-DOTATATE PET lesions within the myocardium of neuroendocrine tumor (NET) patients are observed in clinical practice. We determined the frequency and characteristics of lesions that are consistent with cardiac metastasis and assessed the lesion detection rate of conventional imaging. Methods 629 patients who underwent 68Ga-DOTATATE PET-CT at a supraregional comprehensive cancer center on NET were included from a consecutive registry. Inclusion criteria were: (1) focal 68Ga-DOTATATE tracer uptake within the myocardium in more than two sequential PET exams, and (2) contrast-enhanced CT. To determine the diagnostic accuracy of conventional CT imaging, a case-control cohort with a ratio of 1:3 was used. PET and CT were independently analyzed by two blinded readers. Cohen’s κ was assessed for interreader agreement. Descriptive statistics were applied for frequencies and characteristics and group comparisons were analyzed using the Fisher’s exact test. Results The prevalence of myocardial metastases related to the registry was 2.4% (15 of 629 NET patients fulfilling the inclusion criteria), for a total of 21 myocardial 68Ga-DOTATATE foci detected. Myocardial lesions were most frequently located in the left ventricle (43%) and the septum (43%). No patient demonstrated a pericardial effusion. Patients with myocardial metastases did not differ in demographics, tumor grading, disease stage or circulating tumor markers compared to the overall registry (all p > 0.05). Higher Ki67-Indices were observed (p = 0.049) for patients with myocardial metastases. Interreader agreement for PET assessment was excellent (Cohen’s κ = 1.0). CT reading showed a sensitivity of 19% (95% confidence interval: 6–43%) at a specificity of 100% (95% confidence interval: 90–100%). Conclusions 68Ga-DOTATATE PET enables detection of myocardial metastatic lesions in NET patients. In contrast, standard morphologic CT imaging provides very limited sensitivity.

Published
2018

17. Population study of Galactic supernova remnants at very high γ-ray energies with H.E.S.S

Author

Christo Venter, H. Iwasaki, Gilles Maurin, Q. Piel, J. F. Glicenstein, J. Becker Tjus, A. Zech, M. Büchele, Julien Lefaucheur, Nachiketa Chakraborty, R. Liu, C. Mariaud, L. O'c. Drury, A.M. Taylor, C. Perennes, T. Garrigoux, Riaan Steenkamp, Ruben Lopez-Coto, Pierre Brun, M. Lemoine-Goumard, A. Wörnlein, P.-O. Petrucci, H. Ndiyavala, G. Lamanna, S. J. Fegan, A. Djannati-Ataï, N. W. Pekeur, P. Wagner, Alison Mitchell, Dieter Horns, Jean-Pierre Ernenwein, Zorawar Wadiasingh, B. Condon, I. Shilon, M. Seglar-Arroyo, Jan Conrad, Marco Padovani, Clemens Hoischen, A. A. Zdziarski, Frank M. Rieger, Johannes Veh, D. Gottschall, D. A. Sanchez, J. Hawkes, Anne Lemiere, Gavin Rowell, M. Bryan, R. C. G. Chaves, E. O. Angüner, Reinhard Schlickeiser, D. Zaborov, D. Jankowsky, Monica Barnard, A. S. Seyffert, Axel Donath, R. de los Reyes, A. W. Chen, M. Tluczykont, D. Fernandez, V. Poireau, Cameron B Rulten, C. Romoli, K. Morå, F. Gaté, Felix Spanier, I. Jung-Richardt, Manuel Meyer, H. Abdalla, Christian Stegmann, I. Oya, Stefan Wagner, Yasunobu Uchiyama, D. Wouters, M. A. Kastendieck, G. Vasileiadis, Nu. Komin, Jim Hinton, Y. A. Gallant, Fabian Schüssler, Matteo Cerruti, Stefan Ohm, Markus Holler, Felix Jankowsky, J. Decock, M. Mayer, S. Pita, Dmitry Khangulyan, Dorit Glawion, E. Moulin, Tomasz Bulik, S. Nakashima, J. Zorn, Robert Wagner, Thomas Lohse, L. Mohrmann, Felix Aharonian, L. Dirson, C. Farnier, Ramin Marx, E. Leser, M. Panter, U. Katz, Stefano Gabici, J. Dyks, C. van Rensburg, Werner Hofmann, G. Emery, Samar Safi-Harb, Thomas Vuillaume, B. Khélifi, S. Saito, Justine Devin, M. Lorentz, S. Bonnefoy, Constantin Steppa, M. Füßling, S. Eschbach, Jacek Niemiec, G. Hermann, Regis Terrier, Stefan Klepser, A. Balzer, Heinrich J. Völk, M. Mohamed, Olaf Reimer, P. P. Krüger, F. Voisin, D. Klochkov, Alexandre Marcowith, D.A. Prokhorov, M. Renaud, F. Zefi, D. Kerszberg, Rachel Simoni, Helen Poon, M. Jingo, R. D. Parsons, D. J. van der Walt, L. Oakes, J. Bolmont, I. Sushch, A. Ivascenko, R. Blackwell, S. Colafrancesco, Michael Backes, H. Prokoph, Masanori Arakawa, Gianluca Giavitto, V. Marandon, K. Dutson, Thomas Murach, Joachim Hahn, J. Lau, M. Settimo, Andreas Quirrenbach, Sami Caroff, Włodek Kluźniak, M. Capasso, S. Krakau, V. Sahakian, P. Bordas, Michael Zacharias, F. Niederwanger, J. P. Lees, H. Odaka, Tim Holch, S. Raab, A. Abramowski, G. Heinzelmann, N. Maxted, Krzysztof Katarzynski, A. Jacholkowska, Naomi Tsuji, Tanya Edwards, K. Kosack, Konrad Bernlöhr, Jacco Vink, Catherine Boisson, L. Tibaldo, D. Berge, Christoph Deil, Sabrina Casanova, Gerard Fontaine, G. Pelletier, B. Peyaud, Ullrich Schwanke, G. Pühlhofer, Johan Bregeon, J.-P. Tavernet, Kleopas Shiningayamwe, R. J. White, A. Reimer, A. Viana, Domenico Tiziani, D. Malyshev, Łukasz Stawarz, S. Bernhard, B. van Soelen, Michal Ostrowski, B. Rudak, J.-P. Lenain, F. Ait Benkhali, P. T. O'Brien, M. V. Fernandes, Manami Sasaki, S. Schwemmer, Andrea Santangelo, Gilles Henri, C. van Eldik, Stefan Funk, Alicja Wierzcholska, Marek Jamrozy, Helene Sol, B. Giebels, R. J. Tuffs, L. Jouvin, Iryna Lypova, Yvonne Becherini, K. Egberts, J. Chevalier, R. Rauth, Thomas Tavernier, N. Shafi, Natalia Żywucka, M. de Naurois, Ruizhi Yang, Tadayuki Takahashi, A. Schulz, Isak Delberth Davids, A. Fiasson, Roberta Zanin, P. Willmann, C. Trichard, P. J. Meintjes, A. Ziegler, H. Laffon, M. Arrieta, P. deWilt, J. King, Marion Spir-Jacob, Maria Haupt, Michelle Tsirou, L. Rinchiuso, Rafal Moderski, A. Carosi, Francois Brun, P. Vincent, M.-H. Grondin, Markus Böttcher, M. Katsuragawa, Pierre-Henri Aubert, M. Kraus, Michael Punch, Laboratoire Univers et Théories ( LUTH ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Univers et Particules de Montpellier ( LUPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ), Centre d'Etudes Nucléaires de Bordeaux Gradignan ( CENBG ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Laboratoire Leprince-Ringuet ( LLR ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Centre de Physique des Particules de Marseille ( CPPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Aix Marseille Université ( AMU ), Institut de Planétologie et d'Astrophysique de Grenoble ( IPAG ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), HESS, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), and API Other Research (FNWI)

Subjects
electron, Milky Way, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astrophysics::High Energy Astrophysical Phenomena, Hochenergie-Astrophysik Theorie - Abteilung Hofmann, Infrarot-Astrophysik - Abteilung Hofmann, Cosmic ray, magnetic field, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Compact star, 7. Clean energy, 01 natural sciences, Luminosity, HESS, 0103 physical sciences, supernova, ddc:530, luminosity, flux: upper limit, cosmic radiation: acceleration, 010303 astronomy & astrophysics, HESS - Abteilung Hofmann, Astrophysics::Galaxy Astrophysics, ISM: supernova remnants, Astroparticle physics, Physics, radio wave, density, energy: high, cosmic radiation: spectrum, 010308 nuclear & particles physics, supernova remnants [ISM], Molecular cloud, shell model, Institut für Physik und Astronomie, Astronomy and Astrophysics, gamma rays: general, Galactic plane, Supernova, gamma ray: VHE, Space and Planetary Science, cosmic radiation: galaxy, ddc:520, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], general [gamma rays]
Abstract

著者人数: H.E.S.S. Collaboration 253名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 桂川, 美穂; 中島, 真也; 小高, 裕和; 高橋, 忠幸), Number of authors: H.E.S.S. Collaboration 253 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Katsuragawa, Miho; Nakashima, Shinya; Odaka, Hirokazu; Takahashi, Tadayuki), Accepted: 2018-02-08, 資料番号: SA1170368000

Published
2018

18. The supernova remnant W49B as seen with H.E.S.S. and Fermi-LAT

Author

M. Jingo, Ullrich Schwanke, I. Jung-Richardt, Markus Holler, Victor Zabalza, A. G. Akhperjanian, Michael Punch, Felix Jankowsky, I. Shilon, K. Dutson, D. Jankowsky, Felix Spanier, N. Shafi, Natalia Żywucka, T. Garrigoux, M. de Naurois, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, J. Dyks, Mateusz Janiak, Felix Aharonian, H. Laffon, S. Eschbach, F. Spies, Ruizhi Yang, Marco Padovani, L. Mohrmann, C. van Rensburg, Thomas Tavernier, F. Niederwanger, A. Marcowith, C. Mariaud, Dieter Horns, Clemens Hoischen, A. A. Zdziarski, M. Lorentz, A. Schulz, Christoph Deil, T. Jogler, Gavin Rowell, M. Bryan, D. Zaborov, R. de los Reyes, P. Bordas, Nachiketa Chakraborty, Jacco Vink, Sabrina Casanova, R. Liu, C. Romoli, David Salek, E. Moulin, Tomasz Bulik, G. Lamanna, A. Fiasson, Christo Venter, Daniel Kerszberg, Ruben Lopez-Coto, M. Lemoine-Goumard, J. Lau, A. Jacholkowska, P. Willmann, Francois Brun, M. Chrétien, R. Moderski, A. Zech, B. Condon, Riaan Steenkamp, P. Wagner, M. Mayer, David Sánchez, Jacek Niemiec, Maria Haupt, Olaf Reimer, J. Becker Tjus, Thomas Murach, J. Chevalier, J. Hawkes, Krzysztof Katarzynski, Gilles Fontaine, Frank M. Rieger, Denis Wouters, Julien Lefaucheur, J. Bregeon, P.-O. Petrucci, Guillaume Dubus, L. O'c. Drury, Matteo Cerruti, F. Krayzel, R. Chalme-Calvet, Reinhard Schlickeiser, A. S. Seyffert, W. Kluźniak, D. Klochkov, M.-H. Grondin, N. W. Pekeur, Markus Böttcher, F. Zefi, Alison Mitchell, Zorawar Wadiasingh, D.A. Prokhorov, Michal Ostrowski, R. C. G. Chaves, J.-P. Lenain, Stefan Ohm, K. Morå, R. Blackwell, E. O. Angüner, Werner Hofmann, J. Decock, Pierre-Henri Aubert, S. Pita, J. Jeffrey Carr, Monica Barnard, L. Dirson, S. Öttl, F. Voisin, G. Heinzelmann, S. Colafrancesco, Stefano Gabici, Regis Terrier, Jan Conrad, N. Maxted, Aion Viana, C. Perennes, Nu. Komin, K. Egberts, M. Kraus, B. Peyaud, G. Pelletier, M. Kieffer, P. deWilt, A. Wörnlein, H. Odaka, Andrew M. Taylor, Stefan Funk, Alicja Wierzcholska, Ramin Marx, M. Panter, J. King, F. Ait Benkhali, Manami Sasaki, U. Katz, S. Schwemmer, R. J. Tuffs, S. J. Fegan, A. Djannati-Ataï, Andrea Santangelo, L. Tibaldo, M. Füßling, F. Schüssler, A. Balzer, R. J. White, Marek Jamrozy, Helene Sol, Domenico Tiziani, C. Trichard, I. D. Davids, Olivier Hervet, C. B. Rulten, P. J. Meintjes, Mariangela Settimo, Pierre Brun, Y. Cui, Rachel Simoni, Helen Poon, Joachim Hahn, M. Capasso, A. Ziegler, S. Krakau, V. Sahakian, C. Boisson, C. Farnier, M. Gajdus, E. Leser, Jean-Pierre Ernenwein, G. Cologna, Daniela Hadasch, B. Khélifi, G. Hermann, Johannes Veh, V. Lefranc, Heinrich J. Völk, M. Renaud, S. Bernhard, B. van Soelen, B. Rudak, M. Tluczykont, B. Degrange, H. Abdalla, M. A. Kastendieck, D. Gottschall, Anne Lemiere, Stefan Klepser, G. Vasileiadis, A. Ivascenko, Gilles Maurin, Y. A. Gallant, Łukasz Stawarz, Andreas Quirrenbach, Robert Wagner, Thomas Lohse, Justine Devin, Michael Zacharias, Léa Jouvin, T. Andersson, D. Kolitzus, M. Arrieta, Pascal Vincent, T. Vuillaume, Heike Prokoph, A. Förster, K. Stycz, J. F. Glicenstein, D. J. van der Walt, L. Oakes, J. Bolmont, I. Sushch, Axel Donath, A. W. Chen, Gilles Henri, Q. Piel, R. D. Parsons, F. Stinzing, B. Giebels, Junichiro Katsuta, Gianluca Giavitto, I. Oya, Tanya Edwards, S. Rosier-Lees, G. Spengler, Jim Hinton, M. Mohamed, Michael Backes, W. Domainko, J. P. Lees, S. Raab, A. Abramowski, P. P. Krüger, V. Marandon, D. Berge, Arti Goyal, J.-P. Tavernet, Iryna Lypova, Yvonne Becherini, P. T. O'Brien, Manuel Meyer, M. V. Fernandes, Peter Eger, C. van Eldik, K. Kosack, Konrad Bernlöhr, G. Pühlhofer, A. Reimer, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), API Other Research (FNWI), ATLAS (IHEF, IoP, FNWI), Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), HESS, Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire d'Annecy de Physique des Particules (LAPP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Hochenergie-Astrophysik Theorie - Abteilung Hofmann, Infrarot-Astrophysik - Abteilung Hofmann, FOS: Physical sciences, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 7. Clean energy, Spectral line, 0103 physical sciences, Binary star, ddc:530, Supernova remnant, 010303 astronomy & astrophysics, HESS - Abteilung Hofmann, Cherenkov radiation, Astrophysics::Galaxy Astrophysics, Astroparticle physics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Computer Science::Information Retrieval, supernova remnants [ISM], [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Institut für Physik und Astronomie, Astronomy and Astrophysics, Supernova, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], ddc:520, Astrophysics - High Energy Astrophysical Phenomena, general [gamma rays], clouds [ISM], Fermi Gamma-ray Space Telescope
Abstract

The supernova remnant (SNR) W49B originated from a core-collapse supernova that occurred between one and four thousand years ago, and subsequently evolved into a mixed-morphology remnant, which is interacting with molecular clouds (MC). $\gamma$-ray observations of SNR/MC associations are a powerful tool to constrain the origin of Galactic cosmic-rays, as they can probe the acceleration of hadrons through their interaction with the surrounding medium and subsequent emission of non-thermal photons. The detection of a $\gamma$-ray source coincident with W49B at very high energies (VHE; E > 100 GeV) with the H.E.S.S. Cherenkov telescopes is reported together with a study of the source with 5 years of Fermi-LAT high energy $\gamma$-ray (0.06 - 300 GeV) data. The smoothly-connected combined source spectrum, measured from 60 MeV to multi-TeV energies, shows two significant spectral breaks at $304\pm20$ MeV and $8.4_{-2.5}^{+2.2}$ GeV, the latter being constrained by the joint fit from the two instruments. The detected spectral features are similar to those observed in several other SNR/MC associations and are found to be indicative of $\gamma$-ray emission produced through neutral-pion decay., Comment: 10 pages, 6 figures. Accepted for publication in A&A

Published
2018

19. 18F–FDG-PET/CT and diffusion-weighted MRI for monitoring a BRAF and CDK 4/6 inhibitor combination therapy in a murine model of human melanoma

Author

Georg Keinrath, Jens Ricke, Maurice Heimer, Wolfgang G. Kunz, Ralf S. Eschbach, Andrei Todica, Philipp M. Kazmierczak, Peter Bartenstein, Clemens C. Cyran, Heidrun Hirner-Eppeneder, Maximilian F. Reiser, Moritz Schneider, Jessica Olivier, and Olga Solyanik

Subjects
BRAF inhibitor, lcsh:Medical physics. Medical radiology. Nuclear medicine, 0301 basic medicine, Combination therapy, lcsh:R895-920, Diffusion-weighted MRI, lcsh:RC254-282, CDK inhibitor, 18F–FDG-PET, 03 medical and health sciences, 0302 clinical medicine, Cyclin-dependent kinase, Medicine, Radiology, Nuclear Medicine and imaging, Melanoma, Therapy monitoring, Radiological and Ultrasound Technology, biology, Cyclin-dependent kinase 4, business.industry, Dabrafenib, General Medicine, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Cyclin-dependent kinase 6, business, Ex vivo, Research Article, medicine.drug
Abstract

Background The purpose of the study was to investigate a novel BRAF and CDK 4/6 inhibitor combination therapy in a murine model of BRAF-V600-mutant human melanoma monitored by 18F–FDG-PET/CT and diffusion-weighted MRI (DW-MRI). Methods Human BRAF-V600-mutant melanoma (A375) xenograft-bearing balb/c nude mice (n = 21) were imaged by 18F–FDG-PET/CT and DW-MRI before (day 0) and after (day 7) a 1-week BRAF and CDK 4/6 inhibitor combination therapy (n = 12; dabrafenib, 20 mg/kg/d; ribociclib, 100 mg/kg/d) or placebo (n = 9). Animals were scanned on a small animal PET after intravenous administration of 20 MBq 18F–FDG. Tumor glucose uptake was calculated as the tumor-to-liver-ratio (TTL). Unenhanced CT data sets were subsequently acquired for anatomic coregistration. Tumor diffusivity was assessed by DW-MRI using the apparent diffusion coefficient (ADC). Anti-tumor therapy effects were assessed by ex vivo immunohistochemistry for validation purposes (microvascular density – CD31; tumor cell proliferation – Ki-67). Results Tumor glucose uptake was significantly suppressed under therapy (∆TTLTherapy − 1.00 ± 0.53 vs. ∆TTLControl 0.85 ± 1.21; p

Published
2018

20. A search for new supernova remnant shells in the Galactic plane with H.E.S.S

Author

Maria Haupt, Michael Backes, H. Iwasaki, Jacek Niemiec, Axel Donath, A. W. Chen, J. P. Lees, Ramin Marx, M. Panter, U. Katz, Gilles Henri, I. Oya, Tim Holch, Olaf Reimer, M.-H. Grondin, Nachiketa Chakraborty, K. Dutson, Markus Böttcher, F. Spies, S. Raab, A. Abramowski, G. Spengler, Thomas Tavernier, Naomi Tsuji, M. Mohamed, Nu. Komin, L. Jouvin, Włodek Kluźniak, G. Cologna, Rafal Moderski, S. Bonnefoy, P. T. O'Brien, M. V. Fernandes, W. Domainko, J. Carr, Matteo Cerruti, C. van Eldik, Gerard Fontaine, M. Jingo, Yasuo Fukui, Emmanuel Moulin, G. Lamanna, Konrad Bernlöhr, Clemens Hoischen, A. A. Zdziarski, G. Pühlhofer, Thomas Murach, Ullrich Schwanke, A. Reimer, Manuel Meyer, Arache Djannati-Ataï, M. Katsuragawa, Pierre-Henri Aubert, K. Egberts, Anne Lemiere, Heinrich J. Völk, M. Renaud, B. Giebels, H. Prokoph, Victor Zabalza, Christoph Deil, F. Niederwanger, C. Trichard, A. G. Akhperjanian, F. Zefi, M. Kraus, I. D. Davids, P. J. Meintjes, Y. Cui, Werner Hofmann, Tadayuki Takahashi, G. Pelletier, B. Peyaud, R. C. G. Chaves, E. O. Angüner, A. Ziegler, R. Liu, Jacco Vink, H. Laffon, Alexandre Marcowith, P. deWilt, Robert Wagner, Thomas Lohse, Stefan Klepser, I. Shilon, K. Morå, Sabrina Casanova, F. Ait Benkhali, J. King, M. Füßling, Ruben Lopez-Coto, Manami Sasaki, M. Lemoine-Goumard, S. Schwemmer, A. Balzer, D. Klochkov, P. Bordas, J. Chevalier, Stefan Ohm, A. Ivascenko, D. Berge, S. Pita, P. Wagner, M. Gajdus, Michael Punch, Andrea Santangelo, Marek Jamrozy, T. Andersson, D. Kolitzus, R. Blackwell, C. Farnier, Michal Ostrowski, Helene Sol, E. Leser, Stefano Gabici, Thomas Vuillaume, S. Nakashima, P. Eger, M. Arrieta, S. Saito, Aya Bamba, C. Romoli, J. Hawkes, A. Förster, Hidetoshi Sano, J.-P. Tavernet, J.-P. Lenain, M. Capasso, J. Dyks, Christo Venter, Andrew M. Taylor, D. Jankowsky, Aion Viana, Christian Stegmann, Stefan Wagner, Q. Piel, Johan Bregeon, Karl Kosack, M. Mayer, Felix Spanier, Arti Goyal, Iryna Lypova, Stefan Funk, Alicja Wierzcholska, Łukasz Stawarz, Yvonne Becherini, B. Khélifi, G. Hermann, Yasunobu Uchiyama, S. Krakau, L. Mohrmann, Regis Terrier, F. Schüssler, A. Zech, N. Shafi, Natalia Żywucka, N. Maxted, M. de Naurois, V. Sahakian, L. Oakes, R. J. White, V. Lefranc, J. Bolmont, I. Sushch, M. Janiak, C. van Rensburg, S. Bernhard, Francois Brun, B. van Soelen, B. Rudak, Dieter Horns, S. Richter, D. A. Sanchez, T. Garrigoux, P. Vincent, Joachim Hahn, B. Degrange, R. J. Tuffs, Frank M. Rieger, M. Seglar-Arroyo, Domenico Tiziani, Andreas Quirrenbach, M. Lorentz, Gilles Maurin, Riaan Steenkamp, H. Abdalla, D. Gottschall, D. Kerszberg, M. A. Kastendieck, K. Stycz, Michael Zacharias, C. Mariaud, J. Becker Tjus, Ruizhi Yang, G. Vasileiadis, Denis Wouters, Rachel Simoni, Helen Poon, J. Decock, P.-O. Petrucci, Masanori Arakawa, F. Voisin, J. F. Glicenstein, N. W. Pekeur, A. Schulz, S. Colafrancesco, D.A. Prokhorov, Cameron B Rulten, I. Jung-Richardt, A. Fiasson, Roberta Zanin, S. Öttl, Marco Padovani, Jim Hinton, P. Willmann, Dmitry Khangulyan, A. S. Seyffert, D. J. van der Walt, Gavin Rowell, M. Bryan, O. Hervet, D. Zaborov, Markus Holler, Jan Conrad, Felix Jankowsky, R. de los Reyes, A. Jacholkowska, G. Heinzelmann, Tanya Edwards, Felix Aharonian, David Salek, Tomasz Bulik, S. Eschbach, Julien Lefaucheur, M. Coffaro, R. D. Parsons, Alison Mitchell, Zorawar Wadiasingh, B. Condon, Gianluca Giavitto, Monica Barnard, M. Settimo, L. Tibaldo, H. Odaka, Reinhard Schlickeiser, Pierre Brun, Jean-Pierre Ernenwein, L. Dirson, Johannes Veh, M. Tluczykont, Y. A. Gallant, Justine Devin, J. Lau, Satoshi Yoshiike, Krzysztof Katarzynski, Catherine Boisson, T. Jogler, P. P. Krüger, M. Büchele, C. Perennes, A. Wörnlein, L. O. 'C. Drury, S. J. Fegan, V. Marandon, Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), H.E.S.S., Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Univers et Théories ( LUTH ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Univers et Particules de Montpellier ( LUPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ), Centre d'Etudes Nucléaires de Bordeaux Gradignan ( CENBG ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Centre de Physique des Particules de Marseille ( CPPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Aix Marseille Université ( AMU ), Laboratoire Leprince-Ringuet ( LLR ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Institut de Planétologie et d'Astrophysique de Grenoble ( IPAG ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), API Other Research (FNWI), and ATLAS (IHEF, IoP, FNWI)

Subjects
accelerator, Milky Way, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astrophysics::High Energy Astrophysical Phenomena, leptonic, Population, Hochenergie-Astrophysik Theorie - Abteilung Hofmann, Infrarot-Astrophysik - Abteilung Hofmann, FOS: Physical sciences, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, hadronic, cosmic rays, HESS, 0103 physical sciences, supernova, ddc:530, High Energy Stereoscopic System, Supernova remnant, education, 010303 astronomy & astrophysics, HESS - Abteilung Hofmann, Astrophysics::Galaxy Astrophysics, Computer Science::Information Theory, ISM: supernova remnants, High Energy Astrophysical Phenomena (astro-ph.HE), Astroparticle physics, Physics, education.field_of_study, radio wave, particle: relativistic, 010308 nuclear & particles physics, supernova remnants [ISM], Institut für Physik und Astronomie, Astronomy and Astrophysics, Galactic plane, Supernova, Space and Planetary Science, gamma ray, astroparticle physics, cosmic radiation: galaxy, ddc:520, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

著者人数: H.E.S.S. Collaboration 264名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 桂川, 美穂; 中島, 真也; 小高, 裕和; 高橋, 忠幸), Number of authors: H.E.S.S. Collaboration 264 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Katsuragawa, Miho; Nakashima, Shinya; Odaka, Hirokazu; Takahashi, Tadayuki), Accepted: 2017-12-11, 資料番号: SA1170364000

Published
2018

21. DCE-MRI biomarkers for monitoring an anti-angiogenic triple combination therapy in experimental hypopharynx carcinoma xenografts with immunohistochemical validation

Author

Lukas Havla, Brigitte Mack, A. Sterzik, Pamela Zengel, Ralf S. Eschbach, Svenja Roßpunt, Michael Ingrisch, Philipp M. Paprottka, Clemens C. Cyran, Heidrun Hirner, Konstantin Nikolaou, Maximilian F. Reiser, and Matthias Moser

Subjects
Pathology, medicine.medical_specialty, CONTRAST ENHANCED MRI, Cancer therapy, Contrast Media, Angiogenesis Inhibitors, Piperazines, Rats, Nude, Oximes, Biomarkers, Tumor, medicine, Carcinoma, Triple combination, Animals, Radiology, Nuclear Medicine and imaging, Sulfonamides, Hypopharyngeal Neoplasms, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Head and neck tumors, Anti angiogenic, Reproducibility of Results, Magnetic resonance imaging, Dipeptides, General Medicine, Image Enhancement, medicine.disease, Combined Modality Therapy, Immunohistochemistry, Magnetic Resonance Imaging, Xenograft Model Antitumor Assays, Rats, Disease Models, Animal, Celecoxib, Carcinoma, Squamous Cell, Pyrazoles, business
Abstract

Background Novel anti-angiogenic treatments are increasingly complementing established cancer therapy strategies in head and neck tumors. Contrast-enhanced magnetic resonance imaging (MRI) can be applied for early and non-invasive therapy monitoring by non-invasive quantitative assessment of tumor microcirculation as in vivo imaging biomarkers of therapy response. Purpose To monitor the anti-angiogenic effects of a novel combination therapy on experimental head and neck squamous cell carcinomas (HNSCC) with dynamic contrast-enhanced (DCE)-MRI. Material and Methods Athymic rats ( n = 18) with subcutaneous HNSCC xenografts were investigated by DCE-MRI before and after 7 days of a daily triple therapy regimen combining the COX-II-inhibitor celecoxib, the matrix-metalloproteinase-inhibitor GM6001, and the uPA-inhibitor upamostat. Quantitative measurements of tumor blood flow (tBF), tumor blood volume (tBV), and permeability-surface area product (PS) were calculated and validated by immunohistochemistry. Results Mean tBF and tBV in triple-therapy animals decreased significantly from day 0 to day 7 (tBF, 41.0 ± 14.2 to 20.4 ± 5.7 mL/100 mL/min; P 0.05). Immunohistochemical analysis showed a significantly lower tumor vascularity in the therapy group than in the control group (CD31), significantly fewer Ki-67+ proliferating tumor cells and significantly more Capase-3+ apoptotic tumor cells ( P Conclusion DCE-MRI may be a suitable tool for the non-invasive monitoring of the anti-vascular effects of this innovative triple therapy regimen with potential for clinical translation.

Published
2015

22. Readout electronics testing during mass production of FlashCam cameras for the Cherenkov Telescope Array

Author

A. Gadola, Christian Bauer, Gerd Puehlhofer, M. Barcelo, P. J. Rajda, Thomas Kihm, Andrea Santangelo, M. Biegger, S. Bernhard, D. Florin, I. Jung, Giacomo Principe, A. Vollhardt, Jerzy Kasperek, D. Wolf, O. Kalekin, German Hermann, S. Sailer, Robert Lahmann, C. Tenzer, S. Eschbach, Sebastian Diebold, M. Capasso, F. Werner, C. Kalkuhl, C. Foehr, T. Schwab, Thomas Schanz, Olaf Reimer, A. Marszałek, M. Pfeifer, Stefan Funk, K. Zietara, S. Puerckhauer, F. Eisenkolb, U. Straumann, F. Garrecht, and S. Steiner

Subjects
business.industry, Computer science, Astrophysics::High Energy Astrophysical Phenomena, Pulse generator, Astrophysics::Instrumentation and Methods for Astrophysics, Control reconfiguration, Astronomy, Gamma-ray astronomy, Cherenkov Telescope Array, Signal, Observatory, business, Computer hardware, Cherenkov radiation, Energy (signal processing)
Abstract

The Cherenkov Telescope Array (CTA) will be the future observatory for ground-based TeV gamma-ray astronomy. At two sites, one in the northern and one in the southern hemisphere, CTA will feature about one hundred telescopes of different size classes in order to significantly improve the sensitivity and energy range with respect to current Cherenkov facilities. FlashCam is a camera system proposed for the medium-sized telescopes of CTA that implements a fully-digital readout and trigger processing, which allows the reconfiguration of the trigger algorithm and the signal shaping. For the mass production of a substantial number of FlashCam cameras, efficient and reliable testing routines have been developed. In this contribution, the concept and the procedures for large-scale testing of the readout electronics are outlined. Additionally, a fast multi-channel pulse generator specifically designed for the functional testing of FlashCam FADC modules setup is presented.

Published
2017

23. Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7−3946

Author

Csaba Balázs, M. Servillat, F. D'Ammando, D. Nosek, T. Yamamoto, A. Bilinsky, H.-S. Zechlin, Francesco Dazzi, A. Fernández-Barral, Satoshi Yoshiike, Catherine Boisson, Philippe Laporte, K. Nishijima, Yutaka Fujita, T. Armstrong, A. Shalchi, S. Kimura, D. Nakajima, Fuyuki Tokanai, Francesco Longo, S. Pavy, Philip Kaaret, W. van Driel, Gianpiero Tagliaferri, L. Nogués, F. Di Pierro, Wystan Benbow, T. Stolarczyk, Marco Padovani, T. Di Girolamo, Johan Bregeon, J. Rico, R. Wischnewski, A. Sillanpää, T. Grabarczyk, E. Pueschel, P. Blasi, S. D. Vergani, A. De Franco, C. Bonavolontà, J. Prast, J. Zorn, Elisabetta Bissaldi, Giuseppe Malaguti, A. Pe'Er, Stefano Covino, Akira Okumura, Takashi Saito, C. Aramo, Hermine Landt, R. Zanin, E. Fedorova, Shinji Hara, Yutaka Ohira, Petr Janecek, Petar Temnikov, T. B. Humensky, E. Fiandrini, C. Townsley, R. J. White, A. Fiasson, Koji Noda, Takanori Yoshikoshi, Y. Ikeno, Elena Amato, Yasuo Fukui, J. P. Lees, M. Nievas-Rosillo, Vito Conforti, Kazunori Kohri, I. Oya, M. Trifoglio, Gavin Rowell, Jacek Niemiec, Juan Abel Barrio, R. Walter, Stefan Wagner, Teresa Mineo, J. J. Watson, Reiko Orito, Masahiro Teshima, Jim Hinton, A. Pisarski, G. Rodriguez Fernandez, F. De Frondat, Robert Wagner, Pedro L. Luque-Escamilla, G. Morlino, Thomas Lohse, B. Rudak, Olaf Reimer, Josep Martí, Subir Sarkar, Martin White, Johann Cohen-Tanugi, Michiyuki Chikawa, Dusan Mandat, T. Montaruli, M. Mohammed, M. Iori, Oscar Blanch, Giovanni Bonanno, Benjamin Koch, M. A. Lopez, Julien Rousselle, M. Heller, Yusuke Konno, G. Maurin, J. Palacio, S. Gunji, C. Di Giulio, M. Zavrtanik, J.-P. Lenain, Adrian Biland, Michael Backes, Miroslav Filipovic, M. I. Martínez, M. Vazquez Acosta, Nicola Giglietto, J. M. Paredes, G. Fontaine, R. Moderski, A.A. Zdziarski, D. Tescaro, V. Vassiliev, C. van Eldik, H. Siejkowski, Stefan Kimeswenger, Shu Koyama, A. Bonardi, R. Gnatyk, S. Vorobiov, Oleh Petruk, M. Del Santo, Michał Szanecki, C. Delgado, Carole Mundell, Tomasz Szepieniec, Michael G. Burton, Bohdan Hnatyk, M. Capalbi, Kunihito Ioka, Jonathan Granot, Bohdan Novosyadlyj, Petr Schovanek, A. Weinstein, M. Stephan, Vikram V. Dwarkadas, L. Valore, Sabrina Einecke, P. Goldoni, J. Jacquemier, Hiroshi Muraishi, Andreas Quirrenbach, Takeshi Nakamori, Stefan Ohm, G. Busetto, Marcos Santander, A. Wierzcholska, Jaime Rosado, M. Yoshida, M. Huetten, S. Eschbach, Tatsuo Yoshida, Tomasz Bulik, Gino Tosti, Valentina Fioretti, Makoto Sawada, D. Zavrtanik, P. A. Caraveo, Mohamed Rameez, Sylvain Chaty, Nu. Komin, D. Dumas, Michael Zacharias, J. M. Huet, Reshmi Mukherjee, F. Lucarelli, L. Di Venere, Shuta J. Tanaka, F. de Palma, Shiu-Hang Lee, A. W. Chen, A. Giuliani, R. L. C. Starling, V. Beshley, Jonathan S. Lapington, Gilles Ferrand, Giovanni Covone, Rodrigo Nemmen, Tsuyoshi Inoue, R. C. Shellard, P. Cumani, G. Lamanna, Stefan Funk, Michele Doro, Koji Mori, G. Pühlhofer, Hidetoshi Sano, Susumu Inoue, Luis Ángel Tejedor, G. Kukec Mezek, Anderson Caproni, L. Freixas Coromina, M. de Naurois, D. Jankowsky, Yoshiyuki Inoue, Elina Lindfors, Saverio Lombardi, D. della Volpe, Giancarlo Cusumano, Andrea Orlati, S. Mangano, Samar Safi-Harb, Alexandre Marcowith, R. López-Coto, Martin Pohl, J. Lefaucheur, Vincenzo Rizi, Masayuki Tanaka, Shigehiro Nagataki, J. L. Rodriguez, Diego Falceta-Gonçalves, J. E. Ward, Petr Travnicek, I. Sadeh, Dominik Elsässer, P. Wilcox, Tsunefumi Mizuno, Kohta Murase, K. Lalik, M. Ostrowski, Vincenzo Testa, Tsuguya Naito, Matteo Cerruti, N. La Palombara, Yukikatsu Terada, Emmanuel Moulin, A. Balzer, M. Palatka, Samo Stanič, D. D'Urso, Łukasz Stawarz, D. Simone, Giuseppe Romeo, Francesco Giordano, Luca Zampieri, Michiko Ohishi, Giuseppe Leto, J.F. Glicenstein, G. De Cesare, Eleonora Torresi, R. A. Cameron, Katsuaki Asano, Ricardo Graciani, Gernot Maier, Paweł Wójcik, R. A. Ong, Jörg R. Hörandel, Carlo Vigorito, S. P. Wakely, Valerio Vagelli, Andrea Bulgarelli, J. Takeda, S. Brau-Nogué, Garret Cotter, Claudio Melioli, Hiroaki Yamamoto, M. Vrastil, Ryo Yamazaki, G. Maneva, N. Maxted, David A. Williams, K. Kosack, Konrad Bernlöhr, Markus Böttcher, Andreas Zech, Jürgen Knödlseder, Daniel Nieto, Paola Grandi, Maria Concetta Maccarone, Y. Inome, I. Telezhinsky, Fabio Acero, Michael C. B. Ashley, D. A. Sanchez, C. de Lisio, Francisco J. Franco, J. L. Dournaux, M. Kraus, G. Bonnoli, Xian Chen, Massimo Persic, Jonathan Blazek, Giacomo Principe, Louis Antonelli, H. Hakobyan, A. De Angelis, Marek Nikolajuk, F. Schüssler, T. Nagayoshi, P.-O. Petrucci, P. Sangiorgi, N. Sakaki, Anthony M. Brown, S. Tsujimoto, J. J. Rodríguez Vázquez, A. Morselli, B. De Lotto, Juan Carlos Helo, S. Nozaki, M. Takahashi, Lili Yang, H. Schoorlemmer, Catherine Braiding, Justin Vandenbroucke, J. A. Graham, P. Vallania, Stanislav Stefanik, M. Fesquet, Roberto Aloisio, Diego F. Torres, Ciro Bigongiari, C. Díaz, Shohei Yanagita, M. Garczarczyk, Abelardo Moralejo, Hideaki Katagiri, R. de los Reyes Lopez, A. Burtovoi, M. Hussein, Hiroyasu Tajima, M. Prouza, M. Renaud, C. Trichard, M. K. Daniel, Maria Chernyakova, Tarek M. Hassan, A. Ziegler, E. M. de Gouveia Dal Pino, Ll. Font, J. Kocot, Jiri Chudoba, J. P. Amans, Enrico Junior Schioppa, Alessandro Costa, Aya Bamba, A. Förster, F. Arqueros, Jan Ebr, M. Hayashida, A. J. Green, Marc Ribó, Olga Sergijenko, Hidetoshi Kubo, A. Porcelli, Tomohiro Inada, J. Biteau, J. Kushida, Jose Luis Contreras, S. Colafrancesco, Nestor Mirabal, V. Bugaev, R. J. García López, Vitalii Sliusar, I. Jung, Kathrin Egberts, G. Fasola, Maxim V. Barkov, Seiji Masuda, P. Romano, Enrico Cascone, V. I. Zhdanov, Elisa Prandini, Helene Sol, Rodolfo Carosi, S. Vercellone, Manuela Vecchi, German Martinez, A. Gadola, S. Griffiths, Satyendra Thoudam, Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPP), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CTA Consortium, High Energy Astrophys. & Astropart. Phys (API, FNWI), Acero F., Aloisio R., Amans J., Amato E., Antonelli L. A., Aramo C., Armstrong T., Arqueros F., Asano K., Ashley M., Backes M., Balazs C., Balzer A., Bamba A., Barkov M., Barrio J. A., Benbow W., Bernlöhr K., Beshley V., Bigongiari C., Biland A., Bilinsky A., Bissaldi E., Biteau J., Blanch O., Blasi P., Blazek J., Boisson C., Bonanno G., Bonardi A., Bonavolontà C., Bonnoli G., Braiding C., Brau-Nogué S., Bregeon J., Brown A. M., Bugaev V., Bulgarelli A., Bulik T., Burton M., Burtovoi A., Busetto G., Böttcher M., Cameron R., Capalbi M., Caproni A., Caraveo P., Carosi R., Cascone E., Cerruti M., Chaty S., Chen A., Chen X., Chernyakova M., Chikawa M., Chudoba J., Cohen-Tanugi J., Colafrancesco S., Conforti V., Contreras J. L., Costa A., Cotter G., Covino S., Covone G., Cumani P., Cusumano G., D’Ammando F., D’Urso D., Daniel M., Dazzi F., De Angelis A., De Cesare G., De Franco A., De Frondat F., de Gouveia Dal Pino E. M., De Lisio C., de los Reyes Lopez R., De Lotto B., de Naurois M., De Palma F., Del Santo M., Delgado C., della Volpe D., Di Girolamo T., Di Giulio C., Di Pierro F., Di Venere L., Doro M., Dournaux J., Dumas D., Dwarkadas V., Díaz C., Ebr J., Egberts K., Einecke S., Elsässer D., Eschbach S., Falceta-Goncalves D., Fasola G., Fedorova E., Fernández-Barral A., Ferrand G., Fesquet M., Fiandrini E., Fiasson A., Filipovíc M. D., Fioretti V., Font L., Fontaine G., Franco F. J., Coromina L. Freixa, Fujita Y., Fukui Y., Funk S., Förster A., Gadola A., López R. Garcia, Garczarczyk M., Giglietto N., Giordano F., Giuliani A., Glicenstein J., Gnatyk R., Goldoni P., Grabarczyk T., Graciani R., Graham J., Grandi P., Granot J., Green A. J., Griffiths S., Gunji S., Hakobyan H., Hara S., Hassan T., Hayashida M., Heller M., Helo J. C., Hinton J., Hnatyk B., Huet J., Huetten M., Humensky T. B., Hussein M., Hörandel J., Ikeno Y., Inada T., Inome Y., Inoue S., Inoue T., Inoue Y., Ioka K., Iori M., Jacquemier J., Janecek P., Jankowsky D., Jung I., Kaaret P., Katagiri H., Kimeswenger S., Kimura S., Knödlseder J., Koch B., Kocot J., Kohri K., Komin N., Konno Y., Kosack K., Koyama S., Kraus M., Kubo H., Mezek G. Kukec, Kushida J., Palombara N. La, Lalik K., Lamanna G., Landt H., Lapington J., Laporte P., Lee S., Lees J., Lefaucheur J., Lenain J.-P., Leto G., Lindfors E., Lohse T., Lombardi S., Longo F., Lopez M., Lucarelli F., Luque-Escamilla P. L., López-Coto R., Maccarone M. C., Maier G., Malaguti G., Mandat D., Maneva G., Mangano S., Marcowith A., Martí J., Martínez M., Martínez G., Masuda S., Maurin G., Maxted N., Melioli C., Mineo T., Mirabal N., Mizuno T., Moderski R., Mohammed M., Montaruli T., Moralejo A., Mori K., Morlino G., Morselli A., Moulin E., Mukherjee R., Mundell C., Muraishi H., Murase K., Nagataki S., Nagayoshi T., Naito T., Nakajima D., Nakamori T., Nemmen R., Niemiec J., Nieto D., Nievas-Rosillo M., Nikołajuk M., Nishijima K., Noda K., Nogues L., Nosek D., Novosyadlyj B., Nozaki S., Ohira Y., Ohishi M., Ohm S., Okumura A., Ong R. A., Orito R., Orlati A., Ostrowski M., Oya I., Padovani M., Palacio J., Palatka M., Paredes J. M., Pavy S., Pe’Er A., Persic M., Petrucci P., Petruk O., Pisarski A., Pohl M., Porcelli A., Prandini E., Prast J., Principe G., Prouza M., Pueschel E., Pühlhofer G., Quirrenbach A., Rameez M., Reimer O., Renaud M., Ribó M., Rico J., Rizi V., Rodriguez J., Fernandez G. Rodriguez, Vázquez J. J. Rodríguez, Romano P., Romeo G., Rosado J., Rousselle J., Rowell G., Rudak B., Sadeh I., Safi-Harb S., Saito T., Sakaki N., Sanchez D., Sangiorgi P., Sano H., Santander M., Sarkar S., Sawada M., Schioppa E. J., Schoorlemmer H., Schovanek P., Schussler F., Sergijenko O., Servillat M., Shalchi A., Shellard R. C., Siejkowski H., Sillanpää A., Simone D., Sliusar V., Sol H., Stanič S., Starling R., Stawarz Ł., Stefanik S., Stephan M., Stolarczyk T., Szanecki M., Szepieniec T., Tagliaferri G., Tajima H., Takahashi M., Takeda J., Tanaka M., Tanaka S., Tejedor L. A., Telezhinsky I., Temnikov P., Terada Y., Tescaro D., Teshima M., Testa V., Thoudam S., Tokanai F., Torres D. F., Torresi E., Tosti G., Townsley C., Travnicek P., Trichard C., Trifoglio M., Tsujimoto S., Vagelli V., Vallania P., Valore L., van Driel W., van Eldik C., Vandenbroucke J., Vassiliev V., Vecchi M., Vercellone S., Vergani S., Vigorito C., Vorobiov S., Vrastil M., Acosta M. L. Vázquez, Wagner S. J., Wagner R., Wakely S. P., Walter R., Ward J. E., Watson J. J., Weinstein A., White M., White R., Wierzcholska A., Wilcox P., Williams D. A., Wischnewski R., Wojcik P., Yamamoto T., Yamamoto H., Yamazaki R., Yanagita S., Yang L., Yoshida T., Yoshida M., Yoshiike S., Yoshikoshi T., Zacharias M., Zampieri L., Zanin R., Zavrtanik M., Zavrtanik D., Zdziarski A., Zech A., Zechlin H., Zhdanov V., Ziegler A., Zorn J., Acero, F., Aloisio, R., Amans, J., Amato, E., Antonelli, L. A., Aramo, C., Armstrong, T., Arqueros, F., Asano, K., Ashley, M., Backes, M., Balazs, C., Balzer, A., Bamba, A., Barkov, M., Barrio, J. A., Benbow, W., Bernlöhr, K., Beshley, V., Bigongiari, C., Biland, A., Bilinsky, A., Bissaldi, E., Biteau, J., Blanch, O., Blasi, P., Blazek, J., Boisson, C., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Braiding, C., Brau Nogué, S., Bregeon, J., Brown, A. M., Bugaev, V., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Böttcher, M., Cameron, R., Capalbi, M., Caproni, A., Caraveo, P., Carosi, R., Cascone, E., Cerruti, M., Chaty, S., Chen, A., Chen, X., Chernyakova, M., Chikawa, M., Chudoba, J., Cohen Tanugi, J., Colafrancesco, S., Conforti, V., Contreras, J. L., Costa, A., Cotter, G., Covino, S., Covone, G., Cumani, P., Cusumano, G., D’Ammando, F., D’Urso, D., Daniel, M., Dazzi, F., De Angelis, A., De Cesare, G., De Franco, A., De Frondat, F., de Gouveia Dal Pino, E. M., De Lisio, C., de los Reyes Lopez, R., De Lotto, B., de Naurois, M., De Palma, F., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Giulio, C., Di Pierro, F., Di Venere, L., Doro, M., Dournaux, J., Dumas, D., Dwarkadas, V., Díaz, C., Ebr, J., Egberts, K., Einecke, S., Elsässer, D., Eschbach, S., Falceta Goncalves, D., Fasola, G., Fedorova, E., Fernández Barral, A., Ferrand, G., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovíc, M. D., Fioretti, V., Font, L., Fontaine, G., Franco, F. J., Coromina, L. Freixa, Fujita, Y., Fukui, Y., Funk, S., Förster, A., Gadola, A., López, R. Garcia, Garczarczyk, M., Giglietto, N., Giordano, F., Giuliani, A., Glicenstein, J., Gnatyk, R., Goldoni, P., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Green, A. J., Griffiths, S., Gunji, S., Hakobyan, H., Hara, S., Hassan, T., Hayashida, M., Heller, M., Helo, J. C., Hinton, J., Hnatyk, B., Huet, J., Huetten, M., Humensky, T. B., Hussein, M., Hörandel, J., Ikeno, Y., Inada, T., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Ioka, K., Iori, M., Jacquemier, J., Janecek, P., Jankowsky, D., Jung, I., Kaaret, P., Katagiri, H., Kimeswenger, S., Kimura, S., Knödlseder, J., Koch, B., Kocot, J., Kohri, K., Komin, N., Konno, Y., Kosack, K., Koyama, S., Kraus, M., Kubo, H., Mezek, G. Kukec, Kushida, J., Palombara, N. La, Lalik, K., Lamanna, G., Landt, H., Lapington, J., Laporte, P., Lee, S., Lees, J., Lefaucheur, J., Lenain, J. P., Leto, G., Lindfors, E., Lohse, T., Lombardi, S., Longo, Francesco, Lopez, M., Lucarelli, F., Luque Escamilla, P. L., López Coto, R., Maccarone, M. C., Maier, G., Malaguti, G., Mandat, D., Maneva, G., Mangano, S., Marcowith, A., Martí, J., Martínez, M., Martínez, G., Masuda, S., Maurin, G., Maxted, N., Melioli, C., Mineo, T., Mirabal, N., Mizuno, T., Moderski, R., Mohammed, M., Montaruli, T., Moralejo, A., Mori, K., Morlino, G., Morselli, A., Moulin, E., Mukherjee, R., Mundell, C., Muraishi, H., Murase, K., Nagataki, S., Nagayoshi, T., Naito, T., Nakajima, D., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas Rosillo, M., Nikołajuk, M., Nishijima, K., Noda, K., Nogues, L., Nosek, D., Novosyadlyj, B., Nozaki, S., Ohira, Y., Ohishi, M., Ohm, S., Okumura, A., Ong, R. A., Orito, R., Orlati, A., Ostrowski, M., Oya, I., Padovani, M., Palacio, J., Palatka, M., Paredes, J. M., Pavy, S., Pe’Er, A., Persic, M., Petrucci, P., Petruk, O., Pisarski, A., Pohl, M., Porcelli, A., Prandini, E., Prast, J., Principe, G., Prouza, M., Pueschel, E., Pühlhofer, G., Quirrenbach, A., Rameez, M., Reimer, O., Renaud, M., Ribó, M., Rico, J., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Rosado, J., Rousselle, J., Rowell, G., Rudak, B., Sadeh, I., Safi Harb, S., Saito, T., Sakaki, N., Sanchez, D., Sangiorgi, P., Sano, H., Santander, M., Sarkar, S., Sawada, M., Schioppa, E. J., Schoorlemmer, H., Schovanek, P., Schussler, F., Sergijenko, O., Servillat, M., Shalchi, A., Shellard, R. C., Siejkowski, H., Sillanpää, A., Simone, D., Sliusar, V., Sol, H., Stanič, S., Starling, R., Stawarz, Ł., Stefanik, S., Stephan, M., Stolarczyk, T., Szanecki, M., Szepieniec, T., Tagliaferri, G., Tajima, H., Takahashi, M., Takeda, J., Tanaka, M., Tanaka, S., Tejedor, L. A., Telezhinsky, I., Temnikov, P., Terada, Y., Tescaro, D., Teshima, M., Testa, V., Thoudam, S., Tokanai, F., Torres, D. F., Torresi, E., Tosti, G., Townsley, C., Travnicek, P., Trichard, C., Trifoglio, M., Tsujimoto, S., Vagelli, V., Vallania, P., Valore, L., van Driel, W., van Eldik, C., Vandenbroucke, J., Vassiliev, V., Vecchi, M., Vercellone, S., Vergani, S., Vigorito, C., Vorobiov, S., Vrastil, M., Acosta, M. L. Vázquez, Wagner, S. J., Wagner, R., Wakely, S. P., Walter, R., Ward, J. E., Watson, J. J., Weinstein, A., White, M., White, R., Wierzcholska, A., Wilcox, P., Williams, D. A., Wischnewski, R., Wojcik, P., Yamamoto, T., Yamamoto, H., Yamazaki, R., Yanagita, S., Yang, L., Yoshida, T., Yoshida, M., Yoshiike, S., Yoshikoshi, T., Zacharias, M., Zampieri, L., Zanin, R., Zavrtanik, M., Zavrtanik, D., Zdziarski, A., Zech, A., Zechlin, H., Zhdanov, V., Ziegler, A., Zorn, J., Acero et al, F., PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Acero, F, Aloisio, R, Amans, J, De Lisio, C, Di Girolamo, T, Valore, L, Covone, G, and Al., Et

Subjects
electron, Supernova Remnants, PARTICLE-ACCELERATION, Cherenkov Telescope Array, Astronomy, leptonic, Telescope Array Experiment, pi, Astrophysics, 01 natural sciences, Supernova Remnant, LARGE-AREA TELESCOPE, Spectral line, spectrum, ISM: individual objects, HESS, Supernova remnant, 010303 astronomy & astrophysics, cosmic ray, Physics, cosmic rays gamma rays: ISM ISM: individual objects (RX J1713.7-3946, G347.3-0.5), spatial distribution, Gamma Ray, Cherenkov radiation, MAGNETIC-FIELD, Gamma ray, COSMIC-RAYS, ISM: individual objects (RX J1713.7–3946, G347.3–0.5), Supernova, cosmic rays, gamma rays: ISM, ISM: individual objects (RX J1713.7-3946, G347.3-0.5), Astronomy and Astrophysics, Space and Planetary Science, gamma ray: emission, G347.3–0.5, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, DIFFUSIVE SHOCK ACCELERATION, Electrónica, Física nuclear, Electricidad, individual objects: RX J1713.7–3946 [ISM], Compton scattering, Gamma Rays, G347.3-0.5), NONTHERMAL, accelerator, X-RAYS, Astrophysics::High Energy Astrophysical Phenomena, INSTABILITY, Cosmic ray, hadronic, GLAST, ISM: individual objects (RX J1713.7-3946, ISM [gamma rays], gas, 0103 physical sciences, supernova, ddc:530, X-ray: emission, GAMMA-RAY EMISSION, AMPLIFICATION, BROAD-BAND EMISSION, MOLECULAR CLOUDS, STREAMING, Astrophysics::Galaxy Astrophysics, Astroparticle physics, 010308 nuclear & particles physics, p: relativistic, Institut für Physik und Astronomie, ASTROFÍSICA, gamma ray: VHE, ddc:520, time dependence, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], RAIOS CÓSMICOS
Abstract

著者人数: 382名 (JAXA職員: 井上, 芳幸 : 小山, 志勇 : Lee, Shiu-Hang), Accepted: 2017-04-12, 資料番号: SA1170071000

Published
2017

24. A polarized fast radio burst at low Galactic latitude

Author

M. de Jong, Michael Punch, Mansi M. Kasliwal, T. A. Pritchard, S. Galatà, K. Egberts, S. Loucatos, C. Tönnis, S. Öttl, G. Pelletier, Ivan Felis, Mitchell B. Mickaliger, Jacek Niemiec, G. Cologna, Robert Wagner, A. Gleixner, C. Racca, P. J. Meintjes, Thomas Lohse, Jamie Farnes, Olaf Reimer, F. Ait Benkhali, L. O'c. Drury, P. de Wilt, R. Chalme-Calvet, I. Salvadori, Kay Graf, Karel Melis, A. Vizzoca, I. El Bojaddaini, G. Heinzelmann, C. B. Rulten, Bruny Baret, Heinrich J. Völk, Manami Sasaki, S. Schwemmer, Q. Piel, Andrea Santangelo, Thomas Vuillaume, Guillaume Dubus, A. Jacholkowska, Simon Johnston, J. Chevalier, Julien Lefaucheur, M. Renaud, K. Dutson, F. Spies, D. Dornic, C. Farnier, A. Trovato, E. Leser, Tanya Edwards, Jean-Pierre Macquart, L. Tibaldo, Thomas Murach, C. Lachaud, A. Marinelli, I. D. Davids, Ramin Marx, M. Panter, U. Katz, Silvia Celli, Timothée Grégoire, D. Kiessling, Antoine Kouchner, Marco Padovani, Matthias Kadler, Francois Brun, A. Ivascenko, E. D. Barr, C. W. James, Daniela Hadasch, C. Perrina, Maria Tselengidou, G. Hermann, Regis Terrier, D. Klochkov, Johan Bregeon, W. Kluzniak, M. Kieffer, P. Vincent, Y. Cui, S. Bernhard, L. Stawarz, A. Ziegler, M.C. Bouwhuis, C. Romoli, Dieter Horns, Mateusz Janiak, B. van Soelen, B. Rudak, T. Michael, Nachiketa Chakraborty, Caterina Tiburzi, N. Zywucka, Alison Mitchell, B. Degrange, Santiago Pita, R. Blackwell, Reinhard Schlickeiser, I. Kreykenbohm, Annarita Margiotta, Jutta Schnabel, M. Jingo, R. J. White, Thomas Eberl, H. Laffon, M. Lotze, Christo Venter, Tommaso Chiarusi, M. Anghinolfi, Maura McLaughlin, Zorawar Wadiasingh, B. Condon, D. A. Sanchez, M. Mayer, V. Lefranc, H. Abdalla, M. A. Kastendieck, S. Bourret, G. Vasileiadis, Iryna Lypova, Yvonne Becherini, G. Illuminati, Clemens Hoischen, A. A. Zdziarski, S. Geisselsoder, I. Shilon, E. O. Angüner, Domenico Tiziani, K. Kosack, Konrad Bernlöhr, A. Enzenhöfer, R. Moderski, V. S. Dhillon, Evan Keane, G. Lamanna, Riaan Steenkamp, Matthew Bailes, M. Füssling, A. Zech, V. Van Elewyck, M. Taiuti, J. Decock, Ullrich Schwanke, Monica Barnard, D. Zaborov, O. Kalekin, M. Circella, Y. A. Gallant, N. D. R. Bhat, A. Creusot, Victor Zabalza, Th. Stolarczyk, B. Vallage, N. Maxted, Dominique Lefèvre, L. Dirson, E. Petroff, D. Jankowsky, M.-H. Grondin, C. Perennes, Markus Böttcher, E. Nezri, A. G. Akhperjanian, Maria Haupt, Jürgen Brunner, G. Pühlhofer, S. Klepser, A. Wörnlein, Denis Wouters, Armin Rest, A. Possenti, R. C. G. Chaves, C. Mueller, P. Coyle, F. Zefi, Poonam Chandra, F. Niederwanger, R. D. Parsons, Anne Deschamps, T. Seitz, Daniele Vivolo, D. J. Champion, C. Sieger, J. Dyks, F. Schüssler, L. Caramete, A. Reimer, Felix Spanier, Dominik Elsässer, H. van Haren, S. R. Bernard, T. Garrigoux, K. Morå, I. Di Palma, L. K. Hardy, David Salek, E. Moulin, Justine Devin, Michal Ostrowski, Tomasz Bulik, J.-P. Lenain, Luigi Antonio Fusco, Thomas Tavernier, Matteo Sanguineti, A. Sánchez-Losa, M. Capasso, S. J. Fegan, A. Djannati-Ataï, G. Riccobene, Gianluca Giavitto, Benjamin Stappers, Gilles Maurin, I. Oya, L. Quinn, Axel Donath, Jacco Vink, A. W. Chen, J. Zúñiga, A. S. Seyffert, R. Miller, Pierre-Henri Aubert, Nu. Komin, Sabrina Casanova, Andrew M. Taylor, Jörn Wilms, M. Kreter, Mark Sullivan, Michael Kramer, S. Krakau, V. Sahakian, R. Bruijn, Andreas Quirrenbach, J-J. Aubert, R. Borrnuth, M. Saldaña, Aion Viana, C. Mariaud, Joao A B Coelho, J. P. Lees, P. Migliozzi, D. J. van der Walt, M. Settimo, C. Vallée, Christian Stegmann, Stefan Wagner, Gisela Anton, Bruno Khelifi, Jan Conrad, M. Marcelin, V. Giordano, M. Lorentz, M. Kraus, D. Kerszberg, T. Avgitas, Rachel Simoni, Helen Poon, J.A. Martínez-Mora, Alexis Coleiro, Antonia Rowlinson, S. Raab, Stefan Funk, Alicja Wierzcholska, B. Peyaud, Yasunobu Uchiyama, R. J. Tuffs, L. Mohrmann, Juan José Hernández-Rey, T. Jogler, D.A. Prokhorov, Michel André, Frank M. Rieger, J.D. Zornoza, A. Schulz, T. Pradier, S. Wagner, A. Abramowski, R. Mele, S. Rosier-Lees, G. Spengler, Yann Hello, J. Lau, C. van Rensburg, M. Holler, R. Coniglione, Arnauld Albert, Emanuele Leonora, A. Balzer, Michael Zacharias, M. Mohamed, Yahya Tayalati, J. Carr, I. Jung-Richardt, A. Mathieu, A. Fiasson, Roberta Zanin, P. Willmann, Hervé Glotin, K. Geyer, K. Roensch, Michael Backes, Alexandre Marcowith, J. King, J. Hofestädt, P. P. Krüger, K. Stycz, Jeff Cooke, S. P. Littlefair, H. Odaka, Felix Jankowsky, N. Shafi, M. de Naurois, Krzysztof Katarzynski, Jim Hinton, Matteo Cerruti, P. Bordas, Robert Lahmann, F. Krayzel, V. Bertin, J. Barrios-Martí, R. Liu, Stefan Ohm, W. van Straten, Christoph Deil, J. Hossl, P. Jaroenjittichai, Léa Jouvin, R. Gracia-Ruiz, T. Andersson, W. Domainko, Gerard Fontaine, Felix Aharonian, J. F. Glicenstein, Maurizio Spurio, V. Popa, Catherine Boisson, D. Drouhin, Paolo Piattelli, Olivier Hervet, Pierre Brun, F. Voisin, M. Jongen, D. Kolitzus, C. Trichard, M. Arrieta, Utane Sawangwit, Heike Prokoph, P. T. O'Brien, Paolo Sapienza, A. Förster, Ruben Lopez-Coto, M. Lemoine-Goumard, Abdelilah Moussa, S. Eschbach, M. V. Fernandes, A.J. Heijboer, Steffen Hallmann, C. Hugon, Ruizhi Yang, D. Turpin, Werner Hofmann, Stefano Gabici, S.F. Biagi, P. Wagner, V. Marandon, Jean-Pierre Ernenwein, C. Distefano, S. Colafrancesco, D. F. E. Samtleben, Vladimir Kulikovskiy, Marek Jamrozy, I. Andreoni, Corinne Donzaud, Vikram Ravi, Joachim Hahn, Shivani Bhandari, L. Oakes, Johannes Veh, M. Tluczykont, M. Caleb, Gilles Henri, J. Bolmont, J. Hawkes, I. Sushch, S. Basa, M. Chrétien, Sarah Burke-Spolaor, M. Gajdus, G.E. Păvălaş, C. Pellegrino, H. Costantini, Peter Eger, F. Stinzing, C. van Eldik, D. Berge, G. De Bonis, B. Giebels, A. Capone, Helene Sol, J. Busto, J. Becker Tjus, J.-P. Tavernet, Gavin Rowell, M. Bryan, R. de los Reyes, P.-O. Petrucci, N. W. Pekeur, Manuel Meyer, A. Goya, M. Burgay, Miguel Ardid, D. Gottschall, Anne Lemiere, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Petroff, E, Burke-Spolaor, S, Keane, Ef, Mclaughlin, Ma, Miller, R, Andreoni, I, Bailes, M, Barr, Ed, Bernard, Sr, Bhandari, S, Bhat, Ndr, Burgay, M, Caleb, M, Champion, D, Chandra, P, Cooke, J, Dhillon, V, Farnes, J, Hardy, Lk, Jaroenjittichai, P, Johnston, S, Kasliwal, M, Kramer, M, Littlefair, Sp, Macquart, Jp, Mickaliger, M, Possenti, A, Pritchard, T, Ravi, V, Rest, A, Rowlinson, A, Sawangwit, U, Stappers, B, Sullivan, M, Tiburzi, C, van Straten, W, Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Avgitas, T, Baret, B, Barrios-Marti, J, Basa, S, Bertin, V, Biagi, S, Borrnuth, R, Bourret, S, Bouwhuis, Mc, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chiarusi, T, Circella, M, Coelho, Jab, Coleiro, A, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Deschamps, A, De Bonis, G, Distefano, C, Di Palma, I, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, Elsasser, D, Enzenhofer, A, Felis, I, Fusco, La, Galata, S, Gay, P, Geisselsoder, S, Geyer, K, Giordano, V, Gleixner, A, Glotin, H, Gregoire, T, Gracia-Ruiz, R, Graf, K, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hossl, J, Hofestadt, J, Hugon, C, Illuminati, G, James, Cwcw, de Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Kiessling, D, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Lefevre, D, Leonora, E, Lotze, M, Loucatos, S, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mathieu, A, Mele, R, Melis, K, Michael, T, Migliozzi, P, Moussa, A, Mueller, C, Nezri, E, Pavalas, Ge, Pellegrino, C, Perrina, C, Piattelli, P, Popa, V, Pradier, T, Quinn, L, Racca, C, Riccobene, G, Roensch, K, Sanchez-Losa, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schnabel, J, Seitz, T, Sieger, C, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Trovato, A, Tselengidou, M, Turpin, D, Tonnis, C, Vallage, B, Vallee, C, Van Elewyck, V, Vivolo, D, Vizzoca, A, Wagner, S, Wilms, J, Zornoza, Jd, Zuniga, J, Abdalla, H, Abramowski, A, Aharonian, F, Benkhali, Fa, Akhperjanian, Ag, Andersson, T, Anguner, Eo, Arrieta, M, Aubert, P, Backes, M, Balzer, A, Barnard, M, Becherini, Y, Tjus, Jb, Berge, D, Bernhard, S, Bernlohr, K, Blackwell, R, Bottcher, M, Boisson, C, Bolmont, J, Bordas, P, Bregeon, J, Brun, F, Brun, P, Bryan, M, Bulik, T, Capasso, M, Casanova, S, Cerruti, M, Chakraborty, N, Chalme-Calvet, R, Chaves, Rcg, Chen, A, Chevalier, J, Chretien, M, Colafrancesco, S, Cologna, G, Condon, B, Conrad, J, Cui, Y, Davids, Id, Decock, J, Degrange, B, Deil, C, Devin, J, de Wilt, P, Dirson, L, Djannati-Atai, A, Domainko, W, Donath, A, Drury, Lo, Dubus, G, Dutson, K, Dyks, J, Edwards, T, Egberts, K, Eger, P, Ernenwein, Jp, Eschbach, S, Farnier, C, Fegan, S, Fernandes, Mv, Fiasson, A, Fontaine, G, Forster, A, Funk, S, Fussling, M, Gabici, S, Gajdus, M, Gallant, Ya, Garrigoux, T, Giavitto, G, Giebels, B, Glicenstein, Jf, Gottschall, D, Goya, A, Grondin, Mh, Hadasch, D, Hahn, J, Haupt, M, Hawkes, J, Heinzelmann, G, Henri, G, Hermann, G, Hervet, O, Hinton, Ja, Hofmann, W, Hoischen, C, Holler, M, Horns, D, Ivascenko, A, Jacholkowska, A, Jamrozy, M, Janiak, M, Jankowsky, D, Jankowsky, F, Jingo, M, Jogler, T, Jouvin, L, Jung-Richardt, I, Kastendieck, Ma, Katarzynski, K, Kerszberg, D, Khelifi, B, Kieffer, M, King, J, Klepser, S, Klochkov, D, Kluzniak, W, Kolitzus, D, Komin, N, Kosack, K, Krakau, S, Kraus, M, Krayzel, F, Kruger, Pp, Laffon, H, Lamanna, G, Lau, J, Lees, Jp, Lefaucheur, J, Lefranc, V, Lemiere, A, Lemoine-Goumard, M, Lenain, Jp, Leser, E, Lohse, T, Lorentz, M, Liu, R, Lopez-Coto, R, Lypova, I, Marandon, V, Marcowith, A, Mariaud, C, Marx, R, Maurin, G, Maxted, N, Mayer, M, Meintjes, Pj, Meyer, M, Mitchell, Amw, Moderski, R, Mohamed, M, Mohrmann, L, Mora, K, Moulin, E, Murach, T, de Naurois, M, Niederwanger, F, Niemiec, J, Oakes, L, O'Brien, P, Odaka, H, Ottl, S, Ohm, S, Ostrowski, M, Oya, I, Padovani, M, Panter, M, Parsons, Rd, Pekeur, Nw, Pelletier, G, Perennes, C, Petrucci, Po, Peyaud, B, Piel, Q, Pita, S, Poon, H, Prokhorov, D, Prokoph, H, Puhlhofer, G, Punch, M, Quirrenbach, A, Raab, S, Reimer, A, Reimer, O, Renaud, M, de los Reyes, R, Rieger, F, Romoli, C, Rosier-Lees, S, Rowell, G, Rudak, B, Rulten, Cb, Sahakian, V, Salek, D, Sanchez, Da, Santangelo, A, Sasaki, M, Schlickeiser, R, Schulz, A, Schussler, F, Schwanke, U, Schwemmer, S, Settimo, M, Seyffert, A, Shafi, N, Shilon, I, Simoni, R, Sol, H, Spanier, F, Spengler, G, Spies, F, Stawarz, L, Steenkamp, R, Stegmann, C, Stinzing, F, Stycz, K, Sushch, I, Tavernet, Jp, Tavernier, T, Taylor, Am, Terrier, R, Tibaldo, L, Tiziani, D, Tluczykont, M, Trichard, C, Tuffs, R, Uchiyama, Y, van der Walt, Dj, van Eldik, C, van Rensburg, C, van Soelen, B, Vasileiadis, G, Veh, J, Venter, C, Viana, A, Vincent, P, Vink, J, Voisin, F, Volk, Hj, Vuillaume, T, Wadiasingh, Z, Wagner, Sj, Wagner, P, Wagner, Rm, White, R, Wierzcholska, A, Willmann, P, Wornlein, A, Wouters, D, Yang, R, Zabalza, V, Zaborov, D, Zacharias, M, Zanin, R, Zdziarski, Aa, Zech, A, Zefi, F, Ziegler, A, Zywucka, N, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Petroff, E., Burke-Spolaor, S., Keane, E. F., Mclaughlin, M. A., Miller, R., Andreoni, I., Bailes, M., Barr, E. D., Bernard, S. R., Bhandari, S., Bhat, N. D. R., Burgay, M., Caleb, M., Champion, D., Chandra, P., Cooke, J., Dhillon, V. S., Farnes, J. S., Hardy, L. K., Jaroenjittichai, P., Johnston, S., Kasliwal, M., Kramer, M., Littlefair, S. P., Macquart, J. P., Mickaliger, M., Possenti, A., Pritchard, T., Ravi, V., Rest, A., Rowlinson, A., Sawangwit, U., Stappers, B., Sullivan, M., Tiburzi, C., van Straten, W., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., Avgitas, T., Baret, B., Barrios-Martí, J., Basa, S., Bertin, V., Biagi, S., Bormuth, R., Bourret, S., Bouwhuis, M.C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chiarusi, T., Circella, M., Coelho, J.A.B., Coleiro, A., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Deschamps, A., De Bonis, G., Distefano, C., Palma, I. Di, Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Bojaddaini, I., Elsässer, D., Enzenhöfer, A., Felis, I., Fusco, L.A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Glotin, H., Grégoire, T., Gracia-Ruiz, R., Graf, K., Hallmann, S., van Haren, H., Heijboer, A.J., Hello, Y., Hernández-Rey, J.J., Hößl, J., Hofestädt, J., Hugon, C., Illuminati, G., James, C.W, de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefèvre, D., Leonora, E., Lotze, M., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J.A., Mathieu, A., Mele, R., Melis, K., Michael, T., Migliozzi, P., Moussa, A., Mueller, C., Nezri, E., Păvălaş, G.E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Riccobene, G., Roensch, K., Sánchez-Losa, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schnabel, J., Seitz, T., Sieger, C., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Trovato, A., Tselengidou, M., Turpin, D., Tönnis, C., Vallage, B., Vallée, C., Van Elewyck, V., Vivolo, D., Vizzoca, A., Wagner, S., Wilms, J., Zornoza, J.D., Zúñiga, J., Abdalla, H., Abramowski, A., Aharonian, F., Benkhali, F. Ait, Akhperjanian, A.G., Andersson, T., Angüner, E.O., Arrieta, M., Aubert, P., Backes, M., Balzer, A., Barnard, M., Becherini, Y., Becker Tjus, J., Berge, D., Bernhard, S., Bernlöhr, K., Blackwell, R., Böttcher, M., Boisson, C., Bolmont, J., Bordas, P., Bregeon, J., Brun, F., Brun, P., Bryan, M., Bulik, T., Capasso, M., Casanova, S., Cerruti, M., Chakraborty, N., Chalme-Calvet, R., Chaves, R.C.G., Chen, A., Chevalier, J., Chrétien, M., Colafrancesco, S., Cologna, G., Condon, B., Conrad, J., Cui, Y., Davids, I.D., Decock, J., Degrange, B., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Ataï, A., Domainko, W., Donath, A., Drury, L.O’C., Dubus, G., Dutson, K., Dyks, J., Edwards, T., Egberts, K., Eger, P., Ernenwein, J.-P., Eschbach, S., Farnier, C., Fegan, S., Fernandes, M.V., Fiasson, A., Fontaine, G., Förster, A., Funk, S., Füßling, M., Gabici, S., Gajdus, M., Gallant, Y.A., Garrigoux, T., Giavitto, G., Giebels, B., Glicenstein, J.F., Gottschall, D., Goyal, A., Grondin, M.-H., Hadasch, D., Hahn, J., Haupt, M., Hawkes, J., Heinzelmann, G., Henri, G., Hermann, G., Hervet, O., Hinton, J.A., Hofmann, W., Hoischen, C., Holler, M., Horns, D., Ivascenko, A., Jacholkowska, A., Jamrozy, M., Janiak, M., Jankowsky, D., Jankowsky, F., Jingo, M., Jogler, T., Jouvin, L., Jung-Richardt, I., Kastendieck, M.A., Katarzyński, K., Kerszberg, D., Khélifi, B., Kieffer, M., King, J., Klepser, S., Klochkov, D., Kluźniak, W., Kolitzus, D., Komin, Nu., Kosack, K., Krakau, S., Kraus, M., Krayzel, F., Krüger, P.P., Laffon, H., Lamanna, G., Lau, J., Lees, J.-P., Lefaucheur, J., Lefranc, V., Lemière, A., Lemoine-Goumard, M., Lenain, J.-P., Leser, E., Lohse, T., Lorentz, M., Liu, R., López-Coto, R., Lypova, I., Marandon, V., Marcowith, A., Mariaud, C., Marx, R., Maurin, G., Maxted, N., Mayer, M., Meintjes, P.J., Meyer, M., Mitchell, A.M.W., Moderski, R., Mohamed, M., Mohrmann, L., Morå, K., Moulin, E., Murach, T., de Naurois, M., Niederwanger, F., Niemiec, J., Oakes, L., O’Brien, P., Odaka, H., Öttl, S., Ohm, S., Ostrowski, M., Oya, I., Padovani, M., Panter, M., Parsons, R.D., Pekeur, N.W., Pelletier, G., Perennes, C., Petrucci, P.-O., Peyaud, B., Piel, Q., Pita, S., Poon, H., Prokhorov, D., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Reimer, A., Reimer, O., Renaud, M., Reyes, R. de lo, Rieger, F., Romoli, C., Rosier-Lees, S., Rowell, G., Rudak, B., Rulten, C.B., Sahakian, V., Salek, D., Sanchez, D.A., Santangelo, A., Sasaki, M., Schlickeiser, R., Schulz, A., Schüssler, F., Schwanke, U., Schwemmer, S., Settimo, M., Seyffert, A.S., Shafi, N., Shilon, I., Simoni, R., Sol, H., Spanier, F., Spengler, G., Spies, F., Stawarz, Ł., Steenkamp, R., Stegmann, C., Stinzing, F., Stycz, K., Sushch, I., Tavernet, J.-P., Tavernier, T., Taylor, A.M., Terrier, R., Tibaldo, L., Tiziani, D., Tluczykont, M., Trichard, C., Tuffs, R., Uchiyama, Y., Walt, D.J. van der, van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Viana, A., Vincent, P., Vink, J., Voisin, F., Völk, H.J., Vuillaume, T., Wadiasingh, Z., Wagner, S.J., Wagner, P., Wagner, R.M., White, R., Wierzcholska, A., Willmann, P., Wörnlein, A., Wouters, D., Yang, R., Zabalza, V., Zaborov, D., Zacharias, M., Zanin, R., Zdziarski, A.A., Zech, A., Zefi, F., Ziegler, A., Żywucka, N., High Energy Astrophys. & Astropart. Phys (API, FNWI), KM3NeT (IHEF, IoP, FNWI), Faculty of Science, Gravitation and Astroparticle Physics Amsterdam, ATLAS (IHEF, IoP, FNWI), GRAPPA (ITFA, IoP, FNWI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Andre, M., Aubert, J. -J., Barrios-Marti, J., Bouwhuis, M. C., Coelho, J. A. B., Di Palma, I., Elsasser, D., Enzenhofer, A., Fusco, L. A., Galata, S., Geisselsoder, S., Gregoire, T., Heijboer, A. J., Hernandez-Rey, J. J., Hobl, J., Hofestadt, J., James, C. W., Kiebling, D., Lefevre, D., Martinez-Mora, J. A., Pavalas, G. E., Sanchez-Losa, A., Saldana, M., Stolarczyk, T., Tonnis, C., Vallee, C., Zornoza, J. D., Zuniga, J., Ait Benkhali, F., Akhperjanian, A. G., Anguner, E. O., Bernlohr, K., Bottcher, M., Chaves, R. C. G., Chretien, M., Davids, I. D., Djannati-Atai, A., Drury, L. O'C., Ernenwein, J. -P., Fernandes, M. V., Forster, A., Fubling, M., Gallant, Y. A., Glicenstein, J. F., Grondin, M. -H., Hinton, J. A., Kastendieck, M. A., Katarzynski, K., Khelifi, B., Kluzniak, W., Komin, N., Kruger, P. P., Lees, J. -P., Lemiere, A., Lenain, J. -P., Lopez-Coto, R., Meintjes, P. J., Mitchell, A. M. W., Mora, K., O'Brien, P., Ottl, S., Parsons, R. D., Pekeur, N. W., Petrucci, P. -O., Puhlhofer, G., de los Reyes, R., Rulten, C. B., Sanchez, D. A., Schussler, F., Seyffert, A. S., Stawarz, L., Tavernet, J. -P., Taylor, A. M., van der Walt, D. J., Volk, H. J., Wagner, S. J., Wagner, R. M., Wornlein, A., Zdziarski, A. A., Zywucka, N., Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques

Subjects
Astrofísica, Astronomy, Astrophysics, Surveys, ISM: structure, Methods: data analysis, Polarization, Astronomy and Astrophysics, Space and Planetary Science, 01 natural sciences, Radio telescopes, data analysis [Methods], 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Line-of-sight, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Linear polarization, Fast radio burst, Galactic Center, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Astrophysics - High Energy Astrophysical Phenomena, polarization–methods, dataanalysis–surveys–ISM, structure, Milky Way, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Radio telescope, 0103 physical sciences, Neutrins, Neutrinos, Astrophysics::Galaxy Astrophysics, Astroparticle physics, Telescopis, 010308 nuclear & particles physics, Galactic plane, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, ddc:520, polarization – methods: data analysis – surveys – ISM: structure, structure [ISM], Methods: data analysi
Abstract

Monthly notices of the Royal Astronomical Society 469(4), 4465 – 4482 (2017). doi:10.1093/mnras/stx1098, We report on the discovery of a new fast radio burst (FRB), FRB 150215, with the Parkes radio telescope on 2015 February 15. The burst was detected in real time with a dispersion measure (DM) of 1105.6 ± 0.8 pc cm$^{−3}$, a pulse duration of 2.8 $^{+1.2}_{-0.5}$ ms, and a measured peak flux density assuming that the burst was at beam centre of 0.7$^{+0.2}_{-0.1}$ Jy. The FRB originated at a Galactic longitude and latitude of 24.66°, 5.28° and 25° away from the Galactic Center. The burst was found to be 43 ± 5 per cent linearly polarized with a rotation measure (RM) in the range −9, Published by Oxford Univ. Press, Oxford

Published
2017

25. αvß3-Integrin-Targeted Magnetic Resonance Imaging for the Assessment of Early Antiangiogenic Therapy Effects in Orthotopic Breast Cancer Xenografts

Author

Thomas Habereder, Ralf S. Eschbach, Konstantin Nikolaou, Philipp M. Kazmierczak, Heidrun Hirner-Eppeneder, Kirsten Lauber, Clemens C. Cyran, Maximilian F. Reiser, Matthias Moser, and Moritz Schneider

Subjects
CD31, Relaxometry, Bevacizumab, Contrast Media, Angiogenesis Inhibitors, Breast Neoplasms, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Breast cancer, In vivo, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, Magnetite Nanoparticles, medicine.diagnostic_test, business.industry, Cancer, Magnetic resonance imaging, Dextrans, General Medicine, medicine.disease, Integrin alphaVbeta3, Magnetic Resonance Imaging, Vascular endothelial growth factor, Disease Models, Animal, Treatment Outcome, chemistry, 030220 oncology & carcinogenesis, Heterografts, Female, business, Nuclear medicine, medicine.drug
Abstract

The aim of this study was to investigate magnetic resonance imaging (MRI) with αvß3-integrin-targeted ultrasmall superparamagnetic iron oxide nanoparticles (RGD-USPIO) for the in vivo monitoring of early antiangiogenic therapy effects in experimental breast cancer.Orthotopic human breast cancer (MDA-MB-231) xenograft-bearing severe combined immunodeficiency mice were imaged before and after a 1-week therapy with the vascular endothelial growth factor receptor-antibody bevacizumab or placebo (n = 10 per group, daily intraperitoneal injections of bevacizumab or a volume-equivalent placebo solution, respectively) on a clinical 3 T scanner (Magnetom Skyra; Siemens Healthcare, Erlangen, Germany) before and 60 minutes after the intravenous injection of RGD-USPIO (P04000; Guerbet, Villepinte, France). R2 relaxometry employing a T2-weighted spin-echo sequence with 4 echo times (echo time, 20/40/60/80 milliseconds; repetition time, 3800 milliseconds; matrix, 128 × 128; field of view, 50 × 50; slice thickness, 1.2 mm; time to acquisition, 25 minutes) was used as semiquantitative measure to determine RGD-USPIO endothelial binding. In addition, the T2-weighted images were used to perform volumetric tumor response assessments. Imaging results were validated by ex vivo multiparametric immunohistochemistry with regard to αvß3-integrin expression, microvascular density (CD31), proliferation (Ki-67), and apoptosis (TUNEL).RGD-USPIO endothelial binding was significantly reduced after vascular endothelial growth factor inhibition, compared with the control group in which an increased endothelial binding was detected ([INCREMENT]R2Therapy = -0.80 ± 0.78 s; [INCREMENT]R2Control = +0.27 ± 0.59 s; P = 0.002). Correspondingly, immunohistochemistry revealed a significantly lower αvß3-integrin expression (91 ± 30 vs 357 ± 72; P0.001), microvascular density (CD31, 109 ± 46 vs 440 ± 208; P0.001), tumor cell proliferation (Ki-67, 4040 ± 1373 vs 6530 ± 1217; P0.001), as well as significantly higher apoptosis (TUNEL, 11186 ± 4387 vs 4017 ± 1191; P = 0.004) in the therapy compared with the control group. Contrary to the changes in αvß3-integrin expression detected by RGD-USPIO MRI, morphology-based tumor response assessments did not show a significant intergroup difference in tumor volume development over the course of the experiment (ΔVolTherapy +71 ± 40 μL vs ΔVolControl +125 ± 81 μL; P0.05).RGD-USPIO MRI allows for the noninvasive assessment of αvß3-integrin expression in the investigated breast cancer model. RGD-USPIO MRI may be applicable for the in vivo monitoring of early antiangiogenic therapy effects in experimental breast cancer, generating possible complementary molecular imaging biomarkers to morphology-based tumor response assessments.

Published
2016

26. Contrast-Enhanced Ultrasound with VEGFR2-Targeted Microbubbles for Monitoring Regorafenib Therapy Effects in Experimental Colorectal Adenocarcinomas in Rats with DCE-MRI and Immunohistochemical Validation

Author

Maximilian F. Reiser, Matthias Moser, Dirk-André Clevert, Jessica Schuster, Heidrun Hirner-Eppeneder, Moritz Schneider, Philipp M. Kazmierczak, Ralf S. Eschbach, Dina Tadros, Michael Ingrisch, and Clemens C. Cyran

Subjects
Pathology, Pyridines, Physiology, Tumor Physiology, Cancer Treatment, lcsh:Medicine, Contrast Media, Apoptosis, Cardiovascular Physiology, Biochemistry, 030218 nuclear medicine & medical imaging, Diagnostic Radiology, chemistry.chemical_compound, 0302 clinical medicine, Basic Cancer Research, Ultrasound Imaging, Medicine and Health Sciences, lcsh:Science, Multidisciplinary, Microbubbles, medicine.diagnostic_test, Cell Death, Chemistry, Radiology and Imaging, Ultrasound, Area under the curve, Immunohistochemistry, Magnetic Resonance Imaging, Oncology, Cell Processes, 030220 oncology & carcinogenesis, Tumor Angiogenesis, Colonic Neoplasms, Blood Circulation, Female, Perfusion, HT29 Cells, Contrast-enhanced ultrasound, Research Article, medicine.medical_specialty, Imaging Techniques, Research and Analysis Methods, 03 medical and health sciences, Rats, Nude, Diagnostic Medicine, Regorafenib, medicine, Animals, Humans, Colorectal Cancer, business.industry, Phenylurea Compounds, Microcirculation, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Magnetic resonance imaging, Cell Biology, Vascular Endothelial Growth Factor Receptor-2, Rats, lcsh:Q, Angiogenesis, Nuclear medicine, business, Biomarkers, Developmental Biology
Abstract

Objectives To investigate contrast-enhanced ultrasound (CEUS) with VEGFR2-targeted microbubbles for monitoring therapy effects of regorafenib on experimental colon carcinomas in rats with correlation to dynamic contrast-enhanced MRI (DCE-MRI) and immunohistochemistry. Materials and Methods Human colorectal adenocarcinoma xenografts (HT-29) were implanted subcutaneously in n =21 (n = 11 therapy group;n = 10 control group) female athymic nude rats (Hsd: RH-Foxn1 (mu)). Animals were imaged at baseline and after a one-week daily treatment with regorafenib or a placebo (10 mg/kg bodyweight), using CEUS with VEGFR2-targeted microbubbles and DCE-MRI. In CEUS tumor perfusion was assessed during an early vascular phase (wash-in area under the curve = WiAUC) and VEGFR2-specific binding during a late molecular phase (signal intensity after 8 (SI8min) and 10 minutes (SI10min)), using a conventional 15L8 linear transducer (transmit frequency 7 MHz, dynamic range 80 dB, depth 25 mm). In DCE-MRI functional parameters plasma flow (PF) and plasma volume (PV) were quantified. For validation purposes, CEUS parameters were correlated with DCE-MRI parameters and immunohistochemical VEGFR2, CD31, Ki-67 and TUNEL stainings. Results CEUS perfusion parameter WiAUC decreased significantly (116,989 +/- 77,048 a.u. to 30,076 +/- 27,095a.u.;p = 0.005) under therapy with no significant changes (133,932 +/- 65,960 a.u. to 84,316 +/- 74,144 a.u.;p = 0.093) in the control group. In the therapy group, the amount of bound microbubbles in the late phase was significantly lower in the therapy than in the control group on day 7 (SI8min: 283 +/- 191 vs. 802 +/- 460 a.u.;p = 0.006);SI10min: 226 +/- 149 vs. 645 +/- 461 a.u.;p = 0.009). PF and PV decreased significantly (PF: 147 +/- 58 mL/100 mL/min to 71 +/- 15 mL/100 mL/min;p = 0.003;PV: 13 +/- 3% to 9 +/- 4%;p = 0.040) in the therapy group. Immunohistochemistry revealed significantly fewer VEGFR2 (7.2 +/- 1.8 vs. 17.8 +/- 4.6;p < 0.001), CD31 (8.1 +/- 3.0 vs. 20.8 +/- 5.7;p < 0.001) and Ki-67 (318.7 +/- 94.0 vs. 468.0 +/- 133.8;p = 0.004) and significantly more TUNEL (672.7 +/- 194.0 vs. 357.6 +/- 192.0;p = 0.003) positive cells in the therapy group. CEUS parameters showed significant (p < 0.05) correlations to DCE-MRI parameters and immunohistochemistry. Conclusions CEUS with VEGFR2-targeted microbubbles allowed for monitoring regorafenib functional and molecular therapy effects on experimental colorectal adenocarcinomas with a significant decline of CEUS and DCE-MRI perfusion parameters as well as a significant reduction of specifically bound microbubbles under therapy, consistent with a reduced expression of VEGFR2.

Published
2016

29. Performance Verification of the FlashCam Prototype Camera for the Cherenkov Telescope Array

Author

A. Gadola, C. Kalkuhl, C. Bauer, G. Hermann, D. Florin, A. Vollhardt, T. Schwab, Robert Lahmann, S. Steiner, D. Wolf, S. Eschbach, M. Capasso, S. Pürckhauer, A. Marszałek, M. Pfeifer, S. Bernhard, F. Werner, I. Jung, Thomas Schanz, Olaf Reimer, Thomas Kihm, Stefan Funk, G. Pühlhofer, C. Tenzer, Sebastian Diebold, K. Zietara, F. Eisenkolb, U. Straumann, F. Garrecht, Giacomo Principe, Jerzy Kasperek, P. J. Rajda, O. Kalekin, C. Föhr, and Andrea Santangelo

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, 01 natural sciences, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Optics, Observatory, 0103 physical sciences, 010303 astronomy & astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Digital signal processing, Cherenkov radiation, Physics, Signal processing, business.industry, Signal reconstruction, Astrophysics::Instrumentation and Methods for Astrophysics, Gamma-ray astronomy, Instrumentation and Detectors (physics.ins-det), Cherenkov Telescope Array, Signal chain, Astrophysics - Instrumentation and Methods for Astrophysics, business, Computer hardware
Abstract

The Cherenkov Telescope Array (CTA) is a future gamma-ray observatory that is planned to significantly improve upon the sensitivity and precision of the current generation of Cherenkov telescopes. The observatory will consist of several dozens of telescopes with different sizes and equipped with different types of cameras. Of these, the FlashCam camera system is the first to implement a fully digital signal processing chain which allows for a traceable, configurable trigger scheme and flexible signal reconstruction. As of autumn 2016, a prototype FlashCam camera for the medium-sized telescopes of CTA nears completion. First results of the ongoing system tests demonstrate that the signal chain and the readout system surpass CTA requirements. The stability of the system is shown using long-term temperature cycling., Comment: 5 pages, 13 figures, Proceedings of the 9th International Workshop on Ring Imaging Cherenkov Detectors (RICH 2016), Lake Bled, Slovenia

Published
2016
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30. A cohort study of haemoglobin and zinc protoporphyrin levels in term Zambian infants

Author

Bernard J. Brabin, P. van Rheenen, S. Eschbach, L. T. T. de Moor, Paediatric Infectious Diseases / Rheumatology / Immunology, and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
Male, Pediatrics, Placenta Diseases, breastfeeding, Placenta, Medicine (miscellaneous), Physiology, Protoporphyrins, FETAL ANEMIA, Cohort Studies, chemistry.chemical_compound, Hemoglobins, Pregnancy, Risk Factors, Odds Ratio, CRITERIA, Infant Nutritional Physiological Phenomena, Nutrition and Dietetics, Anemia, Iron-Deficiency, DEFICIENCY, Breast Feeding, Gestation, GROWTH, Female, Cohort study, medicine.medical_specialty, YOUNG-CHILDREN, Anemia, Zambia, Weaning, iron-deficiency anaemia, complementary feeding, AGE, Predictive Value of Tests, parasitic diseases, medicine, Confidence Intervals, MALAWI, Animals, Humans, HUMAN-MILK, business.industry, Zinc protoporphyrin, Infant, Newborn, Nutritional Requirements, placenta/parasitology, Infant, medicine.disease, Malaria, zinc protoporphyrin, BREAST-FED INFANTS, chemistry, Iron-deficiency anemia, Pregnancy Complications, Parasitic, RISK-FACTORS, Protoporphyrin, business, Breast feeding
Abstract

Objective:To examine zinc-protoporphyrin (ZPP) and haemoglobin levels, and to determine predictors of iron deficiency anaemia (IDA) in Zambian infants.Subjects and methods:Ninety-one women and their normal birth weight (NBW) infants were followed bi-monthly during the first 6 months of life, and iron status, food intake, malaria parasitaemia and growth were monitored. At 4 months, the infants were divided into two groups, and the data were analysed according to whether or not they were exclusively breastfed.Results:Almost two-third of infants were born with low iron stores as defined by ZPP levels, and this proportion increased with age. Over 50% had developed IDA by 6 months. Exclusive breastfeeding at 4 months could be a protective factor for IDA (odds ratio (OR): 0.2; 95% confidence interval (CI): 0.0-1.1). Exclusively breastfed infants had higher haemoglobin values at 4 and 6 months (mean difference 0.6; 95% CI: 0.1-1.2 g/dl and mean difference 0.9; 95% CI: 0.2-1.7 g/dl, respectively), compared with infants with early complementary feeding. In univariate analysis, past or chronic placental malaria appeared to be a predictor of IDA at 4 and 6 months, but the significance was lost in multivariate analysis.Conclusions:Zambian NBW infants are born with low iron stores and have a high risk to develop IDA in the first 6 months of life. Continuation of exclusive breastfeeding after 4 months is associated with a reduction of anaemia. The effect of placental malaria infection on increased risk of infant IDA could not be proven.European Journal of Clinical Nutrition advance online publication, 1 August 2007; doi:10.1038/sj.ejcn.1602862

Published
2008

31. Monitoring Cell Death in Regorafenib-Treated Experimental Colon Carcinomas Using Annexin-Based Optical Fluorescence Imaging Validated by Perfusion MRI

Author

Lukas Havla, Konstantin Nikolaou, Heidrun Hirner-Eppeneder, Matthias Moser, Egon Burian, Ralf S. Eschbach, Maximilian F. Reiser, Philipp M. Kazmierczak, Michel Eisenblätter, and Clemens C. Cyran

Subjects
CD31, Pathology, medicine.medical_specialty, Annexins, Pyridines, Transplantation, Heterologous, lcsh:Medicine, Apoptosis, Biology, Signal-To-Noise Ratio, chemistry.chemical_compound, Rats, Nude, Annexin, Regorafenib, medicine, Biomarkers, Tumor, Animals, Humans, lcsh:Science, Cell Proliferation, Multidisciplinary, medicine.diagnostic_test, Phenylurea Compounds, lcsh:R, Optical Imaging, Microvascular Density, Magnetic resonance imaging, Immunohistochemistry, Magnetic Resonance Imaging, Rats, Platelet Endothelial Cell Adhesion Molecule-1, Ki-67 Antigen, chemistry, Colonic Neoplasms, lcsh:Q, Perfusion, HT29 Cells, Research Article
Abstract

Objective To investigate annexin-based optical fluorescence imaging (OI) for monitoring regorafenib-induced early cell death in experimental colon carcinomas in rats, validated by perfusion MRI and multiparametric immunohistochemistry. Materials and Methods Subcutaneous human colon carcinomas (HT-29) in athymic rats (n = 16) were imaged before and after a one-week therapy with regorafenib (n = 8) or placebo (n = 8) using annexin-based OI and perfusion MRI at 3 Tesla. Optical signal-to-noise ratio (SNR) and MRI tumor perfusion parameters (plasma flow PF, mL/100mL/min;plasma volume PV,%) were assessed. On day 7, tumors underwent immunohistochemical analysis for tumor cell apoptosis (TUNEL),proliferation (Ki-67),and microvascular density (CD31). Results Apoptosis-targeted OI demonstrated a tumor-specific probe accumulation with a significant increase of tumor SNR under therapy (mean Delta +7.78 +/- 2.95, control: -0.80 +/- 2.48, p = 0.021). MRI detected a significant reduction of tumor perfusion in the therapy group (mean Delta PF -8.17 +/- 2.32 mL/100 mL/min, control -0.11 +/- 3.36 mL/100 mL/min, p = 0.036). Immunohistochemistry showed significantly more apoptosis (TUNEL;11392 +/- 1486 vs. 2921 +/- 334, p = 0.001),significantly less proliferation (Ki-67;1754 +/- 184 vs. 2883 +/- 323, p = 0.012),and significantly lower microvascular density (CD31;107 +/- 10 vs. 182 +/- 22, p = 0.006) in the therapy group. Conclusions Annexin-based OI allowed for the non-invasive monitoring of regorafenib-induced early cell death in experimental colon carcinomas, validated by perfusion MRI and multiparametric immunohistochemistry.

Published
2015

33. Primary Care Practitioners’ Understanding of Physiatric Practice: Effects on Intention to Refer

Author

Cristin McKenna, Virginia U. Collier, Kelly S. Eschbach, and Neil J. Farber

Subjects
Male, Scope of practice, Attitude of Health Personnel, Internal medicine physicians, medicine.medical_treatment, Psychological intervention, Physical Therapy, Sports Therapy and Rehabilitation, Primary care, Nursing, Surveys and Questionnaires, Humans, Medicine, Referral and Consultation, Setting national, Analysis of Variance, Rehabilitation, business.industry, Outcome measures, Physicians, Family, Middle Aged, Physical and Rehabilitation Medicine, Physiatrists, Logistic Models, Female, business
Abstract

McKenna C, Farber NJ, Eschbach KS, Collier VU. Primary care practitioners' understanding of physiatric practice: effects on intention to refer. Objectives To learn what family practice and internal medicine physicians understand about the scope of practice of physical medicine and rehabilitation (PM&R) and to study what effect that understanding and various demographic variables have on their intention to refer to physiatrists. Design Survey-based. Setting National survey. Participants One thousand internal medicine and family practice physicians were contacted, with 460 respondents. Interventions Not applicable. Main outcome measures Intention to refer patients to physiatrists using 13 case scenarios (10 appropriate referrals, 4 inappropriate referrals) and self-reported number of referrals per year associated with understanding of 7 skills of physiatrists analyzed by multiple logistic regression analyses. Results Although most respondents were likely to refer to physiatrists, a wide variation existed in the types of patients referred. Physicians with a greater understanding of the scope of physiatric practice were more likely to refer ( P =.003). Female physicians were more likely to refer than male physicians ( P =.003). Conclusions There appears to be an association between an understanding of physiatric practice and primary care practitioners' willingness to refer to PM&R. Primary care physicians should be educated about the benefits of referring patients to physiatrists.

Published
2005

34. Systematic search for high-energy gamma-ray emission from bow shocks of runaway stars

Author

Olivier Hervet, J. Bregeon, H. Iwasaki, Pierre Brun, R. C. G. Chaves, E. O. Angüner, I.D. Davids, F. Ait Benkhali, M. Haupt, G. Cologna, Matteo Cerruti, A. F¨orster, M. Coffaro, Gilles Henri, D. Gottschall, P. Bordas, Tomasz Bulik, A. Jacholkowska, H. Abdalla, Werner Hofmann, S. Gabici, J. Bolmont, S. Colafrancesco, A. Balzer, Marek Jamrozy, S. Fegan, M. Büchele, B. Giebels, Yuzhu Cui, Jim Hinton, N. Chakraborty, Justine Devin, Dieter Horns, A. Djannati-Ataï, B. Condon, M. Böttcher, A. Ivascenko, J. Dyks, Clemens Hoischen, T. Andersson, Mateusz Janiak, K. Dutson, M. Capasso, M. Arrieta, G. Heinzelmann, C. Farnier, Joachim Hahn, Sabrina Casanova, Francois Brun, M. Chrétien, Monica Barnard, Stefan Funk, Y.A. Gallant, T. Garrigoux, Christoph Deil, G. Hermann, M. Füßling, Axel Donath, A. W. Chen, Michael Backes, M. Bryan, M. Gajdus, J. Chevalier, Catherine Boisson, J. Becker Tjus, Jan Conrad, R. Chalme-Calvet, J. Jeffrey Carr, M.-H. Grondin, J.-P. Ernenwein, W. Domainko, S. Bernhard, J.F. Glicenstein, B. Degrange, Pierre-Henri Aubert, L. O'c. Drury, Konrad Bernlöhr, Gianluca Giavitto, A. Abramowski, R. Blackwell, J. Hawkes, P. deWilt, M. V. Fernes, Markus Holler, Peter Eger, D. Berge, Felix Aharonian, A. G. Akhperjanian, Tanya Edwards, S. Eschbach, G. Fontaine, A. Fiasson, K. Egberts, Masanori Arakawa, J. Decock, L. Dirson, Arti Goyal, and Yvonne Becherini

Subjects
Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Photon, Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, Astronomy, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Kinetic energy, Radio spectrum, Interstellar medium, Stars, Space and Planetary Science, ddc:520, Astrophysics::Solar and Stellar Astrophysics, Bow shock (aerodynamics), Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics, Fermi Gamma-ray Space Telescope
Abstract

Context. It has been suggested that the bow shocks of runaway stars are sources of high-energy gamma rays (E > 100 MeV). Theoretical models predicting high-energy gamma-ray emission from these sources were followed by the first detection of non-thermal radio emission from the bow shock of BD+43$^��$ 3654 and non-thermal X-ray emission from the bow shock of AE Aurigae. Aims. We perform the first systematic search for MeV and GeV emission from 27 bow shocks of runaway stars using data collected by the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope (Fermi). Methods. We analysed 57 months of Fermi-LAT data at the positions of 27 bow shocks of runaway stars extracted from the Extensive stellar BOw Shock Survey catalogue (E-BOSS). A likelihood analysis was performed to search for gamma-ray emission that is not compatible with diffuse background or emission from neighbouring sources and that could be associated with the bow shocks. Results. None of the bow shock candidates is detected significantly in the Fermi-LAT energy range. We therefore present upper limits on the high-energy emission in the energy range from 100 MeV to 300 GeV for 27 bow shocks of runaway stars in four energy bands. For the three cases where models of the high-energy emission are published we compare our upper limits to the modelled spectra. Our limits exclude the model predictions for Zeta Ophiuchi by a factor $\approx$ 5., 5 pages, 5 figures, 1 table, accepted by A&A

Published
2014
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35. Regorafenib effects on human colon carcinoma xenografts monitored by dynamic contrast-enhanced computed tomography with immunohistochemical validation

Author

Maximilian F. Reiser, Matthias Moser, Michael Ingrisch, Christiane Bruns, Ralf S. Eschbach, Konstantin Nikolaou, Alexandra Michels, Clemens C. Cyran, Philipp M. Kazmierczak, Lukas Havla, B. Schwarz, and Heidrun Hirner

Subjects
Pathology, medicine.medical_specialty, Pyridines, Science, Vascular permeability, Microcirculation, Capillary Permeability, chemistry.chemical_compound, Regorafenib, In Situ Nick-End Labeling, Carcinoma, medicine, Animals, Humans, Multidisciplinary, TUNEL assay, business.industry, Phenylurea Compounds, Microvascular Density, medicine.disease, Immunohistochemistry, Rats, chemistry, Apoptosis, Colonic Neoplasms, Heterografts, Medicine, Female, Drug Monitoring, Tomography, X-Ray Computed, Nuclear medicine, business, Research Article
Abstract

ObjectiveTo investigate dynamic contrast-enhanced computed tomography for monitoring the effects of regorafenib on experimental colon carcinomas in rats by quantitative assessments of tumor microcirculation parameters with immunohistochemical validation.Materials and methodsColon carcinoma xenografts (HT-29) implanted subcutaneously in female athymic rats (n = 15) were imaged at baseline and after a one-week treatment with regorafenib by dynamic contrast-enhanced computed tomography (128-slice dual-source computed tomography). The therapy group (n = 7) received regorafenib daily (10 mg/kg bodyweight). Quantitative parameters of tumor microcirculation (plasma flow, mL/100 mL/min), endothelial permeability (PS, mL/100 mL/min), and tumor vascularity (plasma volume, %) were calculated using a 2-compartment uptake model. Dynamic contrast-enhanced computed tomography parameters were validated with immunohistochemical assessments of tumor microvascular density (CD-31), tumor cell apoptosis (TUNEL), and proliferation (Ki-67).ResultsRegorafenib suppressed tumor vascularity (15.7±5.3 to 5.5±3.5%; pConclusionsRegorafenib significantly suppressed tumor vascularity (plasma volume) quantified by dynamic contrast-enhanced computed tomography in experimental colon carcinomas in rats with good-to-moderate correlations to an immunohistochemical gold standard. Tumor response biomarkers assessed by dynamic contrast-enhanced computed tomography may be a promising future approach to a more personalized and targeted cancer therapy.

Published
2013

36. Dynamic contrast-enhanced computed tomography imaging biomarkers correlated with immunohistochemistry for monitoring the effects of sorafenib on experimental prostate carcinomas

Author

Philipp M. Paprottka, Dirk A. Clevert, Bernd J. Wintersperger, Maximilian F. Reiser, Clemens C. Cyran, Jobst C. von Einem, Michael Ingrisch, Olaf Dietrich, Christiane Bruns, Konstantin Nikolaou, Ralf S. Eschbach, B. Schwarz, and Rabea Hinkel

Subjects
Sorafenib, Male, Niacinamide, medicine.medical_specialty, Pyridines, Iohexol, Tumor microcirculation, Statistics as Topic, Contrast Media, Computed tomography, Antineoplastic Agents, Sensitivity and Specificity, Prostate, Cell Line, Tumor, medicine, Animals, Radiology, Nuclear Medicine and imaging, medicine.diagnostic_test, business.industry, Phenylurea Compounds, Benzenesulfonates, Prostatic Neoplasms, Reproducibility of Results, Dynamic Contrast Enhanced Computed Tomography, General Medicine, Rats, Tomography x ray computed, medicine.anatomical_structure, Treatment Outcome, Immunohistochemistry, Radiology, business, Tomography, X-Ray Computed, Biomarkers, medicine.drug
Abstract

To investigate dynamic contrast-enhanced computed tomography (DCE-CT) for monitoring the effects of sorafenib on experimental prostate carcinomas in rats by quantitative assessments of tumor microcirculation parameters with immunohistochemical validation.Prostate carcinoma allografts (MLLB-2) implanted subcutaneously in male Copenhagen rats (n=16) were imaged at baseline and after a 1-week treatment course of sorafenib using DCE-CT with iopromide (Ultravist 370, Bayer Pharma, Berlin, Germany) on a dual-source 128-slice CT (Somatom Definition FLASH, Siemens Healthcare, Forchheim, Germany). Scan parameters were as follows: detector width, 38.4 mm; contrast agent volume, 2 mL/kg bodyweight; injection rate, 0.5 mL/s; scan duration, 90 seconds; and temporal resolution, 0.5 seconds. The treatment group (n=8) received daily applications of sorafenib (10 mg/kg bodyweight) via gavage. Quantitative parameters of tumor microcirculation (plasma flow, mL/100 mL/min), endothelial permeability-surface area product (PS, mL/100 mL/min), and tumor vascularity (plasma volume, %) were calculated using a 2-compartment uptake model. DCE-CT parameters were correlated with immunohistochemical assessments of tumor vascularity (RECA-1), cell proliferation (Ki-67), and apoptosis (TUNEL).Sorafenib significantly (P0.05) suppressed tumor perfusion (25.1 ± 9.8 to 9.5 ± 6.0 mL/100 mL/min), tumor vascularity (15.6% ± 11.4% to 5.4% ± 2.1%), and PS (8.7 ± 4.5 to 2.7 ± 2.5 mL/100 mL/min) in prostate carcinomas during the treatment course. Immunohistochemistry revealed significantly lower tumor vascularity in the therapy group than in the control group (RECA-1; 181 ± 24 vs. 314 ± 47; P0.05). In sorafenib-treated tumors, significantly more apoptotic cells (TUNEL; 7132 ± 3141 vs. 3722 ± 1445; P0.05) and significantly less proliferating cells (Ki-67; 9628 ± 1.298 vs. 17,557 ± 1446; P0.05) were observed than those in the control group. DCE-CT tumor perfusion correlated significantly (P0.05) with tumor cell proliferation (Ki-67; r=0.55). DCE-CT tumor vascularity correlated significantly (P0.05) with immunohistochemical tumor cell apoptosis (TUNEL; r=-0.59) and tumor cell proliferation (Ki-67; r=0.68). DCE-CT endothelial PS correlated significantly (P0.05) with immunohistochemical tumor cell apoptosis (TUNEL; r=-0.6) and tumor vascularity (RECA-1; r=0.53). While performing corrections for multiple comparisons, we observed a significant correlation only between DCE-CT tumor vascularity (RECA-1) and tumor cell proliferation (Ki-67).Sorafenib significantly suppressed tumor perfusion, tumor vascularity, and PS quantified by DCE-CT in experimental prostate carcinomas in rats. These functional CT surrogate markers showed moderate correlations with antiangiogenic, antiproliferative, and proapoptotic effects observed by immunohistochemistry. DCE-CT may be applicable for the quantification of noninvasive imaging biomarkers of therapy response to antiangiogenic therapy.

Published
2011

37. Performance

Author

Kelly S, Eschbach

Subjects
Physician Incentive Plans, Quality Assurance, Health Care, Physicians, Insurance, Health, Reimbursement, Humans, Efficiency, Organizational, United States, Quality Indicators, Health Care
Published
2008

38. Is anybody out there?

Author

Kelly S, Eschbach

Subjects
Information Dissemination, Communication, Humans, Societies, Medical
Published
2008

39. A reassuring glimpse into the future

Author

Kelly S, Eschbach

Subjects
Adult, Students, Medical, Career Choice, Education, Medical, Humans, Fellowships and Scholarships, Delaware
Published
2008

41. Alternaria toxins: DNA strand-breaking activity in mammalian cellsin vitro

Author

S. Eschbach, Manfred Metzler, and Erika Pfeiffer

Subjects
Gene isoform, Cell type, Toxin, Alternariol, Glucuronidation, Biology, Toxicology, medicine.disease_cause, biology.organism_classification, Microbiology, Chinese hamster, In vitro, chemistry.chemical_compound, chemistry, Biochemistry, medicine, DNA, Biotechnology
Abstract

Treatment, for 1 h, of cultured Chinese hamster V79 cells, human liver HepG2 cells, and human colon HT-29 cells with theAlternaria toxins alternariol (AOH) and alternariol methyl ether (AME) caused a concentration-dependent induction of DNA strand breaks at concentrations ranging from 5 to 50 micromolar. After treatment for 24 h, DNA strand breaks were observed in HepG2 but not HT-29 cells. Analysis of the 24 h-incubation media of HT-29 cells showed that both toxins were completely conjugated, whereas 75% were still present as unconjugated compounds in the 24 h-media of HepG2 cells. Lysates of both cell types fortified with UDPGA were found to convert both toxins into two glucuronides each, but HT-29 cells exhibited a much high activity than HepG2 cells and gave rise to a different ratio of glucuronides. It is concluded that glucuronidation eliminates the DNA strandbreaking potential of AOH and AME, and that the two glucuronides of eachAlternaria toxin are generated by different UGT isoforms.

Published
2007

42. Correlation of Perfusion MRI and 18F-FDG PET Imaging Biomarkers for Monitoring Regorafenib Therapy in Experimental Colon Carcinomas with Immunohistochemical Validation

Author

Philipp M. Kazmierczak, Lukas Spaeth, Michael Ingrisch, Heidrun Hirner-Eppeneder, Axel Rominger, Jessica Schuster, Janette Carlsen, Ralf S. Eschbach, Lukas Havla, Marcus Hacker, Wolfgang P. Fendler, Moritz Schneider, Clemens C. Cyran, Konstantin Nikolaou, Maximilian F. Reiser, and Matthias Moser

Subjects
Pyridines, lcsh:Medicine, Antineoplastic Agents, Magnetic resonance angiography, Microcirculation, Rats, Nude, chemistry.chemical_compound, Fluorodeoxyglucose F18, In vivo, Regorafenib, Biomarkers, Tumor, medicine, Animals, Humans, lcsh:Science, Multidisciplinary, medicine.diagnostic_test, business.industry, Phenylurea Compounds, lcsh:R, Magnetic resonance imaging, Neoplasms, Experimental, Immunohistochemistry, Rats, chemistry, Positron emission tomography, Positron-Emission Tomography, Colonic Neoplasms, Heterografts, Female, lcsh:Q, Drug Monitoring, Nuclear medicine, business, Perfusion, Magnetic Resonance Angiography, Research Article
Abstract

Objectives To investigate a multimodal, multiparametric perfusion MRI/F-18-fluoro-deoxyglucose (F-18-FDG)-PET imaging protocol for monitoring regorafenib therapy effects on experimental colorectal adenocarcinomas in rats with immunohistochemical validation. Materials and Methods Human colorectal adenocarcinoma xenografts (HT-29) were implanted subcutaneously in n = 17 (n = 10 therapy group;n = 7 control group) female athymic nude rats (Hsd: RH-Foxn1(mu)). Animals were imaged at baseline and after a one-week daily treatment protocol with regorafenib (10 mg/kg bodyweight) using a multimodal, multiparametric perfusion MRI/F-18-FDG-PET imaging protocol. In perfusion MRI, quantitative parameters of plasma flow (PF, mL/100 mL/min), plasma volume (PV,%) and endothelial permeability-surface area product (PS, mL/100 mL/min) were calculated. In F-18-FDG-PET, tumor-to-background-ratio (TTB) was calculated. Perfusion MRI parameters were correlated with TTB and immunohistochemical assessments of tumor microvascular density (CD-31) and cell proliferation (Ki-67). Results Regorafenib significantly (p

Published
2015

43. OC26.04: Single intrauterine fetal demise after laser therapy for twin-twin transfusion syndrome: room for improvement?

Author

F.J. Klumper, A.M. Middeldorp, Dick Oepkes, L. Boons, S. Eschbach, E. Lopriore, and M.C. Haak

Subjects
medicine.medical_specialty, Intrauterine fetal demise, Reproductive Medicine, Radiological and Ultrasound Technology, Laser therapy, business.industry, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, business, Twin Twin Transfusion Syndrome, Surgery
Published
2014

44. Poster 200

Author

Virginia U. Collier, Kelly S. Eschbach, Cristin McKenna, and Neil J. Farber

Subjects
medicine.medical_specialty, Rehabilitation, Referral, business.industry, Family medicine, medicine.medical_treatment, medicine, Physical Therapy, Sports Therapy and Rehabilitation, Physiatrists, business
Published
2005

45. Sensory root level recovery in patients with Frankel A quadriplegia

Author

K S, Eschbach, G J, Herbison, and J F, Ditunno

Subjects
Touch, Sensory Thresholds, Humans, Prospective Studies, Prognosis, Quadriplegia, Spinal Nerve Roots, Spinal Cord Injuries
Abstract

This prospective study was designed to demonstrate root level recovery of sensation in the zone of partial preservation in patients with C4 through C8, Frankel A spinal cord injuries. Subjects were evaluated for pin (n = 18) and light touch (n = 17) sensation. All subjects had normal sensation at the level of injury, and decreased or absent sensation at all levels caudal to that level within the zone of partial preservation; they had absent sensation at all levels below the zone of partial preservation. After the initial examination, patients were evaluated weekly for four weeks, and then at 2, 3, 6, 12, 18, and 24 months postinjury. Six of 18 patients recovered pin sensation and five of 17 recovered light touch within three months of injury. Most subjects who recovered had injuries from C5 through C8. Eleven of 12 C4 patients did not recover pin sensation, and 11 of 11 failed to recover light touch. However, five of six C5 to C8 patients recovered both pin and light touch. The p values (Fisher-Exact tests) for the C4 vs C5 to C8 groups were .004 and .001 for pin and light touch, respectively. In conclusion, approximately 30% of the total population improved one sensory root level, with the C5 to C8 injured patients comprising the majority of this improvement.

Published
1992

46. Isolation and preliminary characterization of the nucleus and the nucleomorph of a cryptomonad, Pyrenomonas salina

Author

P, Hansmann and S, Eschbach

Subjects
Cell Nucleus, Microscopy, Electron, Eukaryota, DNA
Abstract

The cryptomonad cell has presumably arisen by a secondary symbiotic event involving two eukaryotes, and thus is composed of four different DNA-containing compartments (nucleus, nucleomorph, plastid, and mitochondrion). In the present paper, the isolation and quantitative DNA estimation of the host cell nucleus and the nucleomorph, a vestigial eukaryotic nucleus, is presented. In the presence of CaCl2, the host nucleus could be isolated from cells lysed by Triton X-100. For isolation of the nucleomorph, cells were slightly fixed with glutardialdehyde and thereafter, lysed by treatment with proteinase K and Triton X-100, leaving an intact nucleomorph-pyrenoid complex. Nuclei were further purified by isopycnic Percoll density gradient centrifugation. Purity and quality of the two nuclear fractions were checked by means of DAPI-epifluorescence microscopy and electron microscopy. The DNA content of the host nucleus and nucleomorph, determined by the diphenylamine method and by means of quantitative microspectrofluorometry, respectively, was found to be more than 700 times higher in the host nucleus than in the nucleomorph.

Published
1990

50. ChemInform Abstract: ORGANOCOBALT CLUSTER COMPLEXES PART 10, NONACARBONYLTRICOBALTCARBON-SUBSTITUTED CARBONIUM IONS, FURTHER (13)C NMR DATA AND DISCUSSION

Author

M. Ozolins Nestle, Dietmar Seyferth, and C. S. Eschbach

Subjects
chemistry.chemical_compound, Crystallography, Carbon atom, chemistry, Carbonium ion, Inorganic chemistry, Carbon-13, Cluster (physics), Sulfuric acid, General Medicine, Carbon-13 NMR, Spectral line, Ion
Abstract

By using either neat samples or very concentrated solutions in CDCl 3 , the apical cluster carbon 13 C NMR resonances in some neutral RCCo 3 (CO) 9 complexes have been observed in the region δ (C) 255–310 ppm. Apical cluster carbon atom resonances occur in the 13 C spectra of concentrated sulfuric acid solutions of [(OC) 9 Co 3 CCRR′] + cations in the region δ (C) 255–286 ppm. Further discussion of the structure and bonding in these charged species is given.

Published
1975

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