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2. How subsurface and double-core anticyclones intensify the winter mixed-layer deepening in the Mediterranean Sea

Author

A. Barboni, S. Coadou-Chaventon, A. Stegner, B. Le Vu, and F. Dumas

Subjects
Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

The mixed layer is the uppermost layer of the ocean, connecting the atmosphere to the subsurface ocean through atmospheric fluxes. It is subject to pronounced seasonal variations: it deepens in winter due to buoyancy loss and shallows in spring while heat flux increases and restratifies the water column. A mixed-layer depth (MLD) modulation over this seasonal cycle has been observed within mesoscale eddies. Taking advantage of the numerous Argo floats deployed and trapped within large Mediterranean anticyclones over the last decades, we reveal for the first time this modulation at a 10 d temporal scale, free of the smoothing effect of composite approaches. The analysis of 16 continuous MLD time series inside 13 long-lived anticyclones at a fine temporal scale brings to light the importance of the eddy pre-existing vertical structure in setting the MLD modulation by mesoscale eddies. Extreme MLD anomalies of up to 330 m are observed when the winter mixed layer connects with a pre-existing subsurface anticyclonic core, greatly accelerating mixed-layer deepening. The winter MLD sometimes does not achieve such connection but homogenizes another subsurface layer, then forming a multi-core anticyclone with spring restratification. An MLD restratification delay is always observed, reaching more than 2 months in 3 out the 16 MLD time series. The water column starts to restratify outside anticyclones, while the mixed layer keeps deepening and cooling at the eddy core for a longer time. These new elements provide new keys for understanding anticyclone vertical-structure formation and evolution.

Published
2023
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3. Corrected confidence intervals based on the signed root transformation for multi-parameter sequentially designed experiments

Author

D. S. Coad

Subjects
Statistics and Probability, Applied Mathematics, Bivariate analysis, Confidence interval, Transformation (function), Distribution (mathematics), Laplace's method, Statistics, Confidence distribution, Nuisance parameter, Applied mathematics, Statistics, Probability and Uncertainty, Nonlinear regression, Mathematics
Abstract

A two-parameter model is studied in which there is a parameter of interest and a nuisance parameter. Corrected confidence intervals are constructed for the parameter of interest for data from a sequentially designed experiment. This is achieved by considering the distribution of the first component of the bivariate signed root transformation, and then by applying a version of Stein's identity and very weak expansions to determine the correction terms. The accuracy of the approximations is assessed by simulation for three nonlinear regression models with normal errors, a two-population normal model, a logistic model and a Poisson model. An extension of the approach to higher dimensions is briefly discussed.

Published
2014
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5. POSTER SESSIONS SCHEDULE

Author

C Hinkin, M Cuevas, A Rauscher, W Kim, T Fogel, G Walls, M Heran, L Drag, S Akeson, K An, Mark T. Barisa, J Cantor, R Pella, C Ward, D Terry, E Parke, I Grant, K Blackstone, David B. Salisbury, P Davidson, G McDonald, C Strongin, Sudhin A. Shah, R Kim, A Miele, K Carlson, N Cadavid, J Donders, S Mahal, T Feaster, K Griffits, J Mayfield, T Brand, A Vernon, Scott R. Miller, C Price, C Vickery, L Carrion, J Beaute, L Weigand, G Crucian, A Tan, M Shuman, Talin Babikian, T Van Vleet, D La, I Thiruselvam, N Nemanim, L Baum, L Loneman, A Schmitt, R Hoadley, J Keller, J Kim, Bonnie M. Scott, M Edwards, M Rohling, B Palmer, G Godoy-Garcete, Ana Rosario, M Taylor, S Letendre, I Sanchez, A Harmell, David L. McArthur, S Greco, M O'Neil, H Yoshida, Jerome H. Carter, Marie N. Dahdah, E Jeffay, L McCutcheon, E Stambrook, A Rach, A Minassian, S Vinogradov, R Akarakian, S Khen, D Schiehser, M Young-Bernier, B Roberg, P Marchetti, L Kenworthy, P Ross, N Didehbani, M Lally, T Brickell, G Vasilev, D Kansagara, Glen A. Palmer, Amanda R. Rabinowitz, A Bedard, Desiree Byrd, K daCruz, A Torstrick, T Nguyen, M Solomon, E Hanson, S Turecka, J Moskowitz, Catherine Stasio, J Kenton, E Call, J McLeod, H Rossetti, Paula I. Martin, J Wasisco, C Depp, Sunni A. Barnes, R Lange, T Lotze, S Erikson, Samantha E. John, K Gulliver, Daniel N. Allen, M Schoenberg, M Joan, S Hass, D Munic-Miller, N Grant, M Weiner, S. DeBoard Marion, C Waksmunski, H Muetze, K Brady, P Roskos, Cynthia Dunklin, N Puente, K Russler, M Salzberg, I Neeland, J McKeever, A Fonteh, J Peer, M Choe, K Russ, C Marini, E Hui, C Kimmel, N Kecala, L. Schwent Shultz, Shelley Peery, R Gonzalez, C Spickler, E Lanni, L Flaro, E Talbot, E Giese, A Davis, Sam Vogel, D Hachey, W Mittenberg, Kenneth L. Jones, S Mahdavi, V. Alipio Jocson, M Marquine, B Ivins, S Paisley, E Weber, G Silk-Eglit, R Singer, K Barnes, A Ghias, J Sordahl, M Spiers, J Anderson, C Mathiowetz, S Fritz, R Fazio, E Miles-Mason, M Glusman, Octavio A. Santos, Jessica A. Kaczorowski, T Dugbartey, K Burns, A Gottuso, Nicholas J. Pastorek, Shahid Shafi, Librada Callender, R Dean, M Thomas, S Schleicher-Dilks, C Bermudez, J Muir, E Van Ness, R Odom, R Dye, F van der Fluit, C Lindbergh, J Grups, Monica U. Ellis, M Coe, M Schmitter-Edgecombe, S Lanting, Rosemary Dubiel, Katherine W Sullivan, A Bonner-Jackson, A Lyon, Daniel J. Schwartz, M Pachalska, S Hibyan, J Long, S Watson, N Nardi, L Pinto, Claudia Kernan, F Thomas, J Messerly, B Walsh, A Daros, S Margolis, M Cullum, B Rainwater, K Baerresen, M Steenari, M Vertinski, P Klas, A Harrison, J Stewart, R Carrasco, D Storzbach, E VonDran, K Carter, M Baldassarre, R Fares, A Freeman, J Barnett, Maggie C. Happe, M Harrington, D D'Argenio, J Piehl, Jacob Sheynin, C Young, A Anum, W Garmoe, T Barker, O Selnes, C Lobue, J Gray, A Rossi, B Stephens, M Jarrett, G Gilbert, A Graefe, J Gfeller, M Murphy, R Perna, B Gouaux, C Leibson, M Heinly, A Allart, Joshua Harrison, M Dudley, B Henry, S O'Bryan, D Miller, J Kennedy, B Edner, M Curri, F Tremblay, T Becker, J Neff, K Gillis, M Poon, C Ukpabi, J Hall, Victoria C. Merritt, D Nemeth, K Tyson, L Glukhovsky, P Vik, Karen K. Miller, R Schroeder, Christopher C. Giza, Benjamin Jurek, M Dawson, T Susmaras, K Rajendran, T Swirsky-Sacchetti, Joseph DeGutis, K Isham, P Massman, M Collier, L Klimik, D Moore, C Baum, J DiGangi, J Francis, B Baughman, A Patel, D Zink, V Carrión, Claire D. Coles, Sarah N. Mattson, A Reveles, T Novakovic-Agopian, D Drasnin, G Sutton, K Jacquin, J Tsou, John D. Medaglia, C Kane, A Starza-Smith, G Lafleche, M Bidzan, J Stenclik, C Smith, J Spat, G Mucci, M Legarreta, Frank G. Hillary, A Mouanoutoua, I Armstrong, C Isaacs, K Beene, C Songy, A Steed, R McCaffrey, J Loftis, A Levan, J Marcinak, Lisa Delano-Wood, C Draffkorn, A Harley, J Shewchuk, J Lynch, P Lebby, Preeti Sunderaraman, R Verbiest, E Stranks, B Hill, A Zisk, L Bolshin, P Stolberg, J Zamzow, V Culotta, J Gross, J Davis, M Fisher, S Mohammed, D Rosario, L Baade, J Fischer, M Muniz, M Kaminetskaya, W Gomes, J Park, K Netson, M Fanning, G Wallace, Nicholas S. Thaler, C Ayers, R Ellis, J Gonzalez, L Zhao, J Thelen, J Kiefel, J Halperin, J Uderman, R Stephan, L Sweet, K Whithers, F Fonseca, A Fedio, D Cooper, Jessica E. Meyer, J Capps, G Getz, M Palewjala, E Rinehardt, A Fernandez, S Tanner, J Ang, Audrey M. Carson, W Finch, S Evans, Gray Vargas, Ellen B. Braaten, J Murry, B Klein-Tasman, M Adler, E Culnan, G Richardson, A Dominska, T Olivier, A Dedmon, E Lane, C Prince, A Mannarino, B Casto, J Calloway, J Mackillop, C Garrett, John F. Linck, A Parks, S Sorg, W Andrew, G Fong, W Gouvier, L Lacritz, Jennifer Romesser, G Small, L Lashley, James B. Hoelzle, Predict-Hd Investigators, M Sakamoto, A Hart, F Dadis, D Pina, J Paulsen, N Stricker, G Iverson, R Macher, A Stringer, C Saucier, J Gallegos, P Andrews, A Chappell, D Jeste, K Mulligan, Pouneh K. Fazeli, D Harrison, R Romero, D Maricle, Joshua D. Miller, S Patel, Jeffrey M. Robbins, S Mansinghani, W Hoffman, K Espinoza, R Roberts, N Londono, M Douangratdy, K Kelley, O Alhassoon, A Quinones, J Taylor, E Ringdahl, A Ness, N DeFilippis, K Marshall, S Jaehnert, R Vergara, P Harvey, J Iudicello, C Ellis, S Tun, Thomas D. Parsons, Amanda E. Hahn-Ketter, C McAlister, T Patterson, R Gomez, K Kloezeman, J Wingo, C Barrio, Michael B. Reid, M Vasserman, Jacob Cohen, C Golden, C Ciobanu, F Carla, D Dinishak, Louis M. French, E Scharaga, Kirsten A. Schohl, A Newman, A Gold, J Bunting, A Puente, R Heaton, A Boettcher, D Wolff, R Baek, T Giovannetti, B Hummer, A Loughan, Ryan J. McKindles, M Bunner, M Kral, W Cole, C Love, E Corley, A Zomet, F Loya, K Young, P May, K Constantine, A Duhig, V Pankratz, J Tam, Maria T. Schultheis, A Junod, K Wyman-Chick, A Houshyarnejad, A Kent, J Wall, D Gansler, M Bens, M Jerram, C Dombrowski, J Segovia, J Hoblyn, M Geyer, N Pliskin, J Strang, B Fuller, J Kloss, J Paxton, J Chow, L Guatney, K Smith, F Foley, Elizabeth R. Sowell, L Brenner, M Rivera Mindt, A Levine, C Irwin, S Rome, J Neiman-Kimel, L Segalà, G Saini, Scott A. Loe, P Vekaria, H Woolery, M Francis, S Newton, Daniel J. Heyanka, J Link, Stephen G. West, T Ala, W Burns, H Pedersen, M Norman, L Delgaty, C Mihailescu, S Cowad, T Melville, Leila Glass, Nathan D. Doty, E Simco, A Holland, R Robbs, Warren T. Jones, S Banks, X Bonilla, R McCue, C Ramirez, M Phoong, N Upshaw, H England, S Woods, K Whigham, L Miller, J Etherton, S Rolin, Sawsan Dabit, S Kohlrus, S Thomlinson, Ryan Olmstead, A Chen, S Mahmoud, S Mauro, B Greenberg, B Lukaszewska, C Brown, R Moore, B Freer, W MacAllister, S Schaffer, R Fontanetta, J Vassileva, J Fine, Amy Wilson, C O'Shea, L Barker, Joseph J. Graca, Anthony C. Ruocco, E Schulze, Brian I. Miller, A Kaup, K Julie, A Nolty, P Siddarth, Jeffrey S. Karst, B Rabinovitz, S Yudovin, C Faraco, M Raymond, Anita H. Sim, I Kunkes, J Kamm, K Zakzanis, R Petersen, A Rudd-Barnard, N Fritz, A Bozorg, R Wellington, R Naslednikova, R Nogin, J Moses, L Tiersky, T Lee, L Cooper, M Smith, A Papadakis, L Hoskins, L Ashendorf, Caitlin Miranda, J Sexton, S Barney, M Le, M Putnam, Lillie Weiss, D Baldock, D Grimm, H Westervelt, M Mattingly, Yelena Bogdanova, C Hopewell, J Kahne, C Moore, B Mausbach, Robert F. Asarnow, Peter A. Arnett, Michael M. Merzenich, R Remel, S Coad, J Hertza, C Romers, L Harrison, M Daniel, J Clark, A Rowden, B Bristow-Murray, A Reyes, C Noggle, D Yeh, Bridget K. Dolan, Keith D. Cicerone, G Goodman, D Haberman, Mary K. Colvin, M Noback, Hasan Ayaz, B Natalie, M Cohen, Mary F. Musso, G Abrams, Seth A. Gale, J McGinley, E Bene, Ramon Diaz-Arrastia, S Benbadis, S Northington, S O'Neill, R Ruchinskas, M Hall, B Saffer, L Miarmi, F Webbe, Dobrivoje S. Stokic, C Bowie, B Duda, J Bravo, S Taylor, L Wilson, Henry W. Mahncke, R Scott, Ashita S. Gurnani, K Eichstaedt, H Soper, A Andrews, B Evans, J Bailie, R Poulin, K Evankovich, R Relova, A Gremillion, S Hunter, B Lee, M Beier, Edward P. Riley, S Edmed, M Wills, Sarah M. Kark, E Quasney, K Barrera, Yelena Goldin, Kimberley R. Monden, A Barker, V Sterk, J Fink, J Ikanga, Will Lindstrom, B Hunter, D Denney, S Huberman, C Williams, T Otero, K Spengler, A Pulver, Kathryn L Schmidt, J Meyers, E Gutierrez, V Wheaton, K Downing, A Bhagwat, Stephen A. Olson, E Lande, R Lee, F Vale, F Barwick, Mirella Díaz-Santos, C Mosti, Daniel S. Brown, M Benners, L Horne-Moyer, K Johnson, V Vargas, P Sylvester, E Shapiro, Sarah DeBoard Marion, J Poole, E Strongin, K Fields, M Basso, R Lawson, D Brinckman, E Morgan, A Simone, I Raynov, A Matevosyan, J Emerson, M Motu'apuaka, S Heverly-Fitt, Alexandra L. Clark, E March, B Roper, N Dezhkam, N Dasher, V Patt, Sheryl Stevens, A Choi, S Sautter, A Van Hecke, J. Travis Seidl, T Raines, W Perry, L Moss, M Macaluso, G Carlin, S Sisk, B Bowman, John Hart, Elisabeth M. Vogt, Michael D. Ensley, B Schilling, L Ercoli, M Zupanc, V D'Orio, A Bure-Reyes, L Rabin, J Nunan-Saah, N Rodgers-Neame, Jared M. Bruce, E Crouse, C Boys, H Kletter, T Lo, Brandon E. Gavett, A Sherzai, N Bott, K Walker, J Brubacher, Tanya M. Brown, F Ahmed, Dede M. Ukueberuwa, L Etcoff, K Chu, B Schweinsburg, Y Demsky, K Vitelli, M Huckans, L Nakhutina, A Ghelani, C Higginson, R Zec, A Curiel, David C. Osmon, S Crowe, K Phelps, O Prokhorenko, M Koehle, C Morse, Alice Cronin-Golomb, E Batchelor, J Lum, G Brown, L Silva, M Freeman, C Babika, Janine M. Paxson, P Pimental, W Buddin, J Baker, J Kline, F Hays, M Pollock, M Oganes, Armando Fuentes, M Ring, B Thieme, A Psihogios, A Zimmer, J Thompson, Hannah M. Lindsey, O Graham, Christina L. Casnar, M Arce Rentería, A Rooney, K Bozgunov, M Welch, M Lipowska, M Earleywine, S Lewis, T Floyd, A Tanguay, Yongming Li, C Tai, N Fromm, N Luc, K Barchard, K Musielak, Amir Poreh, R Heinrichs, C Boyd, K Schwab, A Lynch, R Wanlass, K Janke, S Bullard, S Hughes, K Hanson, C Holder, A Legenkaya, J Siegel, S Gold, C Evans, F Hill, Caryn R. Harper, D Binder, S Gill, M Bruhns, E Singer, Sidney O'Bryant, and J Atkinson

Subjects
Psychiatry and Mental health, Clinical Psychology, Schedule, Neuropsychology and Physiological Psychology, business.industry, Medicine, Operations management, General Medicine, business
Published
2013
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6. Grand Rounds

Author

G. Fayolle, W. Levick, R. Lajiness-O'Neill, P. Fastenau, S. Briskin, N. Bass, M. Silva, E. Critchfield, R. Nakase-Richardson, J. Hertza, A. Loughan, R. Perna, S. Northington, S. Boyd, A. Anderson, S. Peery, M. Chafetz, M. Maris, A. Ramezani, C. Sylvester, K. Goldberg, M. Constantinou, M. Karekla, J. Hall, M. Edwards, V. Balldin, A. Strutt, V. Pavlik, C. Marquez de la Plata, M. Cullum, l. lacritz, J. Reisch, P. Massman, D. Royall, R. Barber, S. Younes, A. Wiechmann, S. O'Bryant, K. Patel, J. Suhr, S. Chari, J. Yokoyama, B. Bettcher, A. Karydas, B. Miller, J. Kramer, R. Zec, S. Fritz, S. Kohlrus, R. Robbs, T. Ala, K. Gifford, N. Cantwell, R. Romano, A. Jefferson, A. Holland, S. Newton, J. Bunting, M. Coe, J. Carmona, D. Harrison, A. Puente, D. Terry, C. Faraco, C. Brown, A. Patel, A. Watts, A. Kent, J. Siegel, S. Miller, W. Ernst, G. Chelune, J. Holdnack, J. Sheehan, K. Duff, O. Pedraza, J. Crawford, L. Miller, V. Hobson Balldin, H. Benavides, L. Johnson, L. Tshuma, N. Dezhkam, L. Hayes, C. Love, B. Stephens, F. Webbe, K. Mulligan, K. Dunham, S. Shadi, C. Sofko, R. Denney, S. Rolin, J. Sibson, S. Ogbeide, M. Glover, A. Warchol, B. Hunter, C. Nichols, C. Riccio, M. Cohen, A. Dennison, T. Wasserman, S. Schleicher-Dilks, M. Adler, C. Golden, T. Olivier, B. LeMonda, J. McGinley, A. Pritchett, L. Chang, C. Cloak, E. Cunningham, G. Lohaugen, J. Skranes, T. Ernst, E. Parke, N. Thaler, L. Etcoff, D. Allen, P. Andrews, S. McGregor, R. Daniels, N. Hochsztein, E. Miles-Mason, Y. Granader, M. Vasserman, W. MacAllister, B. Casto, K. Patrick, F. Hurewitz, D. Chute, A. Booth, C. Koch, G. Roid, N. Balkema, J. Kiefel, L. Bell, A. Maerlender, T. Belkin, J. Katzenstein, C. Semerjian, V. Culotta, E. Band, R. Yosick, T. Burns, A. Arenivas, D. Bearden, K. Olson, K. Jacobson, S. Ubogy, C. Sterling, E. Taub, A. Griffin, T. Rickards, G. Uswatte, D. Davis, K. Sweeney, A. Llorente, A. Boettcher, B. Hill, D. Ploetz, J. Kline, M. Rohling, J. O'Jile, K. Holler, V. Petrauskas, J. Long, J. Casey, T. Duda, S. Hodsman, S. Stricker, S. Martner, R. Hansen, F. Ferraro, R. Tangen, A. Hanratty, M. Tanabe, E. O'Callaghan, B. Houskamp, L. McDonald, L. Pick, D. Guardino, T. Pietz, K. Kayser, R. Gray, A. Letteri, A. Crisologo, G. Witkin, J. Sanders, M. Mrazik, A. Harley, M. Phoong, T. Melville, D. La, R. Gomez, L. Berthelson, J. Robbins, E. Lane, P. Rahman, L. Konopka, A. Fasfous, D. Zink, N. Peralta-Ramirez, M. Perez-Garcia, S. Su, G. Lin, T. Kiely, A. Schatzberg, J. Keller, J. Dykstra, M. Feigon, L. Renteria, M. Fong, L. Piper, E. Lee, J. Vordenberg, C. Contardo, S. Magnuson, N. Doninger, L. Luton, D. Drane, A. Phelan, W. Stricker, A. Poreh, F. Wolkenberg, J. Spira, J. DeRight, R. Jorgensen, L. Fitzpatrick, S. Crowe, S. Woods, K. Doyle, E. Weber, M. Cameron, J. Cattie, C. Cushman, I. Grant, K. Blackstone, D. Moore, B. Roberg, M. Somogie, J. Thelen, C. Lovelace, J. Bruce, A. Gerstenecker, B. Mast, I. Litvan, D. Hargrave, R. Schroeder, W. Buddin, L. Baade, R. Heinrichs, J. Boseck, K. Berry, E. Koehn, A. Davis, B. Meyer, B. Gelder, Z. Sussman, P. Espe-Pfeifer, M. Musso, A. Barker, G. Jones, W. Gouvier, V. Johnson, L. Zaytsev, M. Freier-Randall, G. Sutton, E. Ringdahl, J. Olsen, D. Byrd, M. Rivera-Mindt, R. Fellows, S. Morgello, V. Wheaton, S. Jaehnert, C. Ellis, H. Olavarria, J. Loftis, M. Huckans, P. Pimental, J. Frawley, M. Welch, K. Jennette, E. Rinehardt, M. Schoenberg, L. Strober, H. Genova, G. Wylie, J. DeLuca, N. Chiaravalloti, E. Ibrahim, A. Seiam, S. Bohlega, H. Lloyd, M. Goldberg, J. Marceaux, R. Fallows, K. McCoy, N. Yehyawi, E. Luther, R. Hilsabeck, R. Fulton, P. Stevens, S. Erickson, P. Dodzik, R. Williams, J. Dsurney, L. Najafizadeh, J. McGovern, F. Chowdhry, A. Acevedo, A. Bakhtiar, N. Karamzadeh, F. Amyot, A. Gandjbakhche, M. Haddad, M. Johnson, J. Wade, L. Harper, A. Barghi, V. Mark, G. Christopher, D. Marcus, M. Spady, J. Bloom, A. Zimmer, M. Miller, D. Schuster, H. Ebner, B. Mortimer, G. Palmer, M. Happe, J. Paxson, B. Jurek, J. Graca, J. Meyers, R. Lange, T. Brickell, L. French, G. Iverson, J. Shewchuk, B. Madler, M. Heran, J. Brubacher, B. Ivins, M. Baldassarre, T. Paper, A. Herrold, A. Chin, D. Zgaljardic, K. Oden, M. Lambert, S. Dickson, R. Miller, P. Plenger, E. Sutherland, C. Glatts, P. Schatz, K. Walker, N. Philip, S. McClaughlin, S. Mooney, E. Seats, V. Carnell, J. Raintree, D. Brown, C. Hodges, E. Amerson, C. Kennedy, J. Moore, C. Ferris, T. Roebuck-Spencer, A. Vincent, C. Bryan, D. Catalano, A. Warren, K. Monden, S. Driver, P. Chau, R. Seegmiller, M. Baker, S. Malach, J. Mintz, R. Villarreal, A. Peterson, S. Leininger, C. Strong, J. Donders, V. Merritt, G. Vargas, A. Rabinowitz, P. Arnett, E. Whipple, M. Schultheis, K. Robinson, D. Iacovone, R. Biester, D. Alfano, M. Nicholls, P. Klas, E. Jeffay, K. Zakzanis, M. Vandermeer, M. Womble, E. Corley, C. Considine, N. Fichtenberg, J. Harrison, M. Pollock, A. Mouanoutoua, A. Brimager, P. Lebby, K. Sullivan, S. Edmed, K. Kieffer, M. McCarthy, L. Wiegand, H. Lindsey, M. Hernandez, Y. Noniyeva, Y. Lapis, M. Padua, J. Poole, B. Brooks, C. McKay, W. Meeuwisse, C. Emery, A. Mazur-Mosiewicz, E. Sherman, M. Kirkwood, J. Gunner, A. Miele, G. Silk-Eglit, J. Lynch, R. McCaffrey, J. Stewart, J. Tsou, D. Scarisbrick, R. Chan, A. Bure-Reyes, L. Cortes, S. Gindy, C. Biddle, D. Shah, P. Jaberg, R. Moss, M. Horner, K. VanKirk, C. Dismuke, T. Turner, W. Muzzy, M. Dunnam, G. Warner, K. Donnelly, J. Donnelly, J. Kittleson, C. Bradshaw, M. Alt, S. Margolis, E. Ostroy, K. Higgins, K. Eng, S. Akeson, J. Wall, J. Davis, J. Hansel, B. Wang, R. Gervais, M. Greiffenstein, J. Denning, E. VonDran, E. Campbell, C. Brockman, G. Teichner, R. Waid, B. Buican, P. Armistead-Jehle, J. Bailie, A. Dilay, M. Cottingham, C. Boyd, S. Asmussen, J. Neff, S. Schalk, L. Jensen, J. DenBoer, S. Hall, E. Holcomb, B. Axelrod, G. Demakis, C. Rimland, J. Ward, M. Ross, M. Bailey, A. Stubblefield, J. Smigielski, J. Geske, V. Karpyak, C. Reese, G. Larrabee, L. Allen, M. Celinski, J. Gilman, C. LaDuke, D. DeMatteo, K. Heilbrun, T. Swirsky-Sacchetti, A. Dedman, K. Withers, T. Deneen, J. Fisher, B. Spray, R. Savage, H. Wiener, J. Tyer, V. Ningaonkar, B. Devlin, R. Go, V. Sharma, R. Fontanetta, C. Calderon, S. Coad, R. Fontaneta, M. Vertinski, R. Verbiest, J. Snyder, J. Kinney, A. Rach, J. Young, E. Crouse, D. Schretlen, J. Weaver, A. Buchholz, B. Gordon, S. Macciocchi, R. Seel, R. Godsall, J. Brotsky, A. DiRocco, E. Houghton-Faryna, E. Bolinger, C. Hollenbeck, J. Hart, B. Lee, G. Strauss, J. Adams, D. Martins, L. Catalano, J. Waltz, J. Gold, G. Haas, L. Brown, J. Luther, G. Goldstein, E. Kelley, C. Raba, L. Trettin, H. Solvason, R. Buchanan, D. Baldock, J. Etherton, T. Phelps, S. Richmond, B. Tapscott, S. Thomlinson, L. Cordeiro, G. Wilkening, M. Parikh, L. Graham, M. Grosch, L. Hynan, M. Weiner, C. Cullum, C. Menon, L. Lacritz, M. Castro-Couch, F. Irani, A. Houshyarnejad, M. Norman, F. Fonseca, B. Browne, J. Alvarez, Y. Jiminez, V. Baez, C. Resendiz, B. Scott, G. Farias, M. York, V. Lozano, M. Mahoney, M. Hernandez Mejia, E. Pacheco, A. Homs, R. Ownby, J. Nici, J. Hom, J. Lutz, R. Dean, H. Finch, S. Pierce, J. Moses, S. Mann, J. Feinberg, A. Choi, M. Kaminetskaya, C. Pierce, M. Zacharewicz, B. Gavett, J. Horwitz, J. Ory, K. Carbuccia, L. Morra, S. Garcon, M. Lucas, P. Donovick, K. Whearty, K. Campbell, S. Camlic, D. Brinckman, L. Ehrhart, V. Weisser, J. Medaglia, A. Merzagora, G. Reckess, T. Ho, S. Testa, H. Woolery, C. Farcello, N. Klimas, J. Meyer, F. Barwick, K. Drayer, J. Galusha, A. Schmitt, R. Livingston, R. Stewart, L. Quarles, M. Pagitt, C. Barke, A. Baker, N. Baker, N. Cook, D. Ahern, S. Correia, L. Resnik, K. Barnabe, D. Gnepp, M. Benjamin, Z. Zlatar, A. Garcia, S. Harnish, B. Crosson, L. Vaughan, A. Fedio, J. Sexton, S. Cummings, A. Logemann, N. Lassiter, P. Fedio, A. Gremillion, D. Nemeth, T. Whittington, J. Reckow, C. Lewandowski, J. Cole, A. Lewandowski, J. Spector, L. Ford-Johnson, J. Lengenfelder, J. Sumowski, C. Morse, J. McKeever, L. Zhao, T. Leist, J. Marcinak, K. Piecora, K. Al-Khalil, P. Martin, L. Thompson, W. Kowalczyk, S. Golub, E. Lemann, J. Piehl, N. Rita, L. Moss, R. Nogin, C. Drapeau, S. Malm, L. Armstrong, R. Glidewell, W. Orr, G. Mears, C. Allen, E. Pierson, B. Kavanaugh, F. Tayim, S. Llanes, K. Poston, J. Beathard, P. Stolberg, W. Jones, J. Mayfield, J. Weller, P. Demireva, K. McInerney, T. Riddle, M. Primus, J. Highsmith, D. Everhart, K. Lehockey, S. Sullivan, S. Mandava, B. Murphy, L. Lalwani, M. Rosselli, R. Carrasco, S. Zuckerman, J. Brand, M. Rivera Mindt, S. Schaffer, K. Alper, O. Devinsky, W. Barr, K. Langer, J. Fraiman, J. Scagliola, E. Roman, A. Martinez, K. Konopacki, A. Juliano, D. Whiteside, G. Widmann, M. Franzwa, B. Sokal, E. Morgan, M. Bondi, L. Delano-Wood, R. Cormier, N. Cumley, M. Elek, M. Green, A. Kruger, L. Pacheco, G. Robinson, H. Welch, D. Parriott, S. Loe, L. Hughes, L. Natta, W. Quenicka, K. McGoldirck, T. Bennett, H. Soper, S. Collier, M. Connolly, M. Di Pinto, E. Handel, K. Davidson, E. Livers, S. Frantz, J. Allen, T. Jerard, S. Sakhai, S. Barney, K. McGoldrick, J. Sordahl, N. Torrence, and S. John

Subjects
Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, General Medicine
Published
2012
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7. Discussion on 'A Hybrid Selection and Testing Procedure with Curtailment for Comparative Clinical Trials' by Elena M. Buzaianu and Pinyuen Chen

Author

D. S. Coad

Subjects
Statistics and Probability, Clinical trial, Chen, biology, Modeling and Simulation, Stopping rule, Stopping rules, Sampling (statistics), biology.organism_classification, Mathematical economics, Selection (genetic algorithm), Mathematics
Abstract

This discussion contains some comments on the paper by Professors Buzaianu and Chen. These concern the form of the two-stage design used and possible future work, such as the consideration of alternative stopping rules, the incorporation of response-adaptive sampling, and the problem of estimation following the design.

Published
2009
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8. Sequential procedures for comparing several normal means

Author

D. S. Coad and A. A. Halimeh

Subjects
Statistics and Probability, Applied Mathematics, Unbiased Estimation, Sample mean and sample covariance, Sequential method, Sample size determination, Modeling and Simulation, Probability of error, Statistics, Range (statistics), Mean vector, Statistics, Probability and Uncertainty, Statistic, Mathematics
Abstract

A sequential clinical trial model is considered in which K≥3 treatments with normally distributed responses and unknown means are compared. For the case of equal variances, four sequential elimination procedures are studied—two based on the between treatments sum-of-squares statistic and two on the range statistic. Simulation indicates that the procedures based on the former statistic are slightly more efficient at determining the treatment with the highest mean. Approximations are also given for the bias of the sample mean vector following the designs and their accuracy is assessed using simu-lation. A generalisation of the procedures based on the between treatments sum-of-squares statistic to the unequal variances case is then considered. Some possible extensions to the work are briefly discussed.

Published
2006
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9. Corrected confidence intervals for adaptive nonlinear regression models

Author

D. S. Coad and Michael Woodroofe

Subjects
Statistics and Probability, Applied Mathematics, Posterior probability, Regression analysis, Function (mathematics), Pivotal quantity, Mathematical proof, Identity (music), Confidence interval, Statistics, Applied mathematics, Statistics, Probability and Uncertainty, Nonlinear regression, Mathematics
Abstract

A nonlinear regression model is considered in which the design variable may be a function of the previous responses. The aim is to construct confidence intervals for the parameter which are asymptotically valid to a high order. This is accomplished by using a tilting argument to construct a first approximation to a pivotal quantity, and then by using a version of Stein's identity and very weak expansions to determine the correction terms. The accuracy of the approximations is assessed by simulation for two well-known nonlinear regression models—the first-order growth or decay model and the Michaelis–Menten model, when one of the two parameters is known. Detailed proofs of the expansions are given.

Published
2005
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11. Corrected confidence intervals following a sequential adaptive clinical trial with binary responses

Author

D. S. Coad and Z. Govindarajulu

Subjects
Statistics and Probability, Sequential estimation, Adaptive clinical trial, Applied Mathematics, Statistics, Boundary (topology), Binary number, Odds ratio, Statistics, Probability and Uncertainty, Pivotal quantity, Selection (genetic algorithm), Confidence interval, Mathematics
Abstract

A sequential clinical trial model is considered in which two treatments are compared and the responses are binary. One of the properties of the model is that, for a given stopping boundary, the error probability is insensitive to the allocation rule. It is shown how a corrected confidence interval may be determined for the log odds ratio at the end of the trial. Simulation is used to assess the accuracy of the method for a selection of stopping boundaries and data-dependent allocation rules.

Published
2000
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12. A comparison of the randomized play-the-winner rule and the triangular test for clinical trials with binary responses

Author

D. S. Coad and William F. Rosenberger

Subjects
Statistics and Probability, Mathematical optimization, Epidemiology, Sequential analysis, Computer science, Sample size determination, Estimation theory, Monte Carlo method, Statistics, Binary number, Expected value, Power function, Test (assessment)
Abstract

We consider a clinical trial model comparing an experimental treatment with a control treatment when the responses are binary. For fixed significance level and power, we compare the expected number of treatment failures for two designs – the randomized play-the-winner rule and the triangular test. The former is an example of an adaptive design while the latter is an example of a fully sequential design. We show how to determine the sample size for the randomized play-the-winner rule and how to choose the stopping boundaries for the triangular test so that the two designs have similar power functions. With this choice of design parameters, simulation indicates that the triangular test is generally more effective at reducing the expected number of treatment failures, particularly when there is a large difference between the two probabilities of success. The expected number of treatment failures can be further reduced if the triangular test is applied using the randomized play-the-winner rule to assign each patient to one of the two treatments. Copyright © 1999 John Wiley & Sons, Ltd.

Published
1999
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13. Discussion on 'Second-Guessing Clinical Trial Designs' by Jonathan J. Shuster and Myron N. Chang

Author

D. S. Coad

Subjects
Statistics and Probability, Clinical trial, Sample size determination, Modeling and Simulation, Adaptive design, Multiple treatments, Mathematical economics, Sufficient statistic, Mathematics
Abstract

This discussion contains a few comments on the paper by Professors Shuster and Chang. These concern the underlying assumptions of their model and possible extensions to the work, such as the consideration of multiple treatments, sample size reestimation, and response-adaptive designs.

Published
2008
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14. Approximate bias calculations for sequentially designed experiments

Author

D. S. Coad and Michael Woodroofe

Subjects
Statistics and Probability, Mathematical optimization, Sequential estimation, Autoregressive model, Sequential analysis, Modeling and Simulation, Stopping time, Linear model, Estimator, Applied mathematics, Variance (accounting), Identity (music), Mathematics
Abstract

A linear model is considered in which the design variables may be functions of previous responses and/or auxiliary randomisation. The model is observed successive times, where t is a stopping time, and interest lies in estimating the parameters of the model. Approximations are derived for the bias and variance of the maximum likelihood estimators of the parameters at time t. The derivations involve differentiating the fundamental identity of sequential analysis. The accuracy of the approximations is assessed by simulation for a multi-armed clinical trial model proposed by Coad (1995), two autoregressive models and the sequential design of Ford and Silvey (1980). Very weak expansions are used to justify the approximations.

Published
1998
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15. Sequential allocation rules for multi-armed clinical trials

Author

D. S. Coad

Subjects
Statistics and Probability, Applied Mathematics, Mean value, Sequential allocation, Clinical trial, Simple (abstract algebra), Sample size determination, Modeling and Simulation, Stopping time, Probability of error, Statistics, Statistics, Probability and Uncertainty, Algorithm, Mathematics
Abstract

A number of well-known sequential allocation rules are compared with a fixed-sample rule as procedures for determining which of k≥2 treatments with normal responses has the largest mean. For known variances, it is shown in the case k=2 how the parameters of the rules can be chosen so that they achieve a similar pattern of error probabilities. A simple modification of the rules is described to deal with the problem of unknown variences. Simulation indicates that the error probabilities for the modified rules are generally no larger than those for the fixed-sample rule. It is also shown that the rules extend naturally to the case of more than two treatments, with many of their important properties being preserved.

Published
1995
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19. Sequential estimation for two-stage and three-stage clinical trials

Author

D. S. Coad

Subjects
Statistics and Probability, N of 1 trial, Clinical trial, Sequential estimation, Three stage, Treatment difference, Applied Mathematics, Statistics, Stage (hydrology), Variance (accounting), Statistics, Probability and Uncertainty, Lead (electronics), Mathematics
Abstract

A clinical trial setting is considered in which two treatments are available for a particular ailment. The responses to the treatments are normally distributed with unknown means and a common known variance. A two-stage trial and a three-stage trial are studied. In the two-stage trial, patients are randomised equally in the first stage, and the better treatment at the end of this stage is used exclusively in the second stage. The three-stage trial permits a second randomised stage before a single treatment is selected. For these designs, the exact bias and variance of the estimated treatment difference at the end of the trial are derived. These quantities are also derived when there are time trends in the data. Numerical results indicate that the presence of time trends can seriously bias the estimated treatment difference and can also lead to an increase in its variance.

Published
1994
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20. Sequential tests with covariates with an application to censored survival data

Author

D. S. Coad

Subjects
Statistics and Probability, Random allocation, Exponential distribution, Survival data, Link function, Statistics, Covariate, Econometrics, Mean and predicted response, Sequential test, Mathematics, Exponential function
Abstract

The problem of incorporating covariate information into sequential tests for deciding which of two treatments is superior is considered. It is assumed that the mean response depends on a number of covariates through an appropriate link function. Two large-sample sequential tests are described, and these tests are derived when the data are censored exponential survival times. Simulation results for random allocation indicate that the error probabilities for the new tests are generally no larger than those for tests derived in the absence of covariate information.

Published
1994
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22. Data-dependent allocation rules a comparative study of some for bernoulli data

Author

D. S. Coad

Subjects
Statistics and Probability, Estimation, Gittins index, Applied Mathematics, Variance (accounting), Response to treatment, Outcome (game theory), Clinical trial, Bernoulli's principle, Modeling and Simulation, Statistics, Econometrics, Statistics, Probability and Uncertainty, Data dependent, Mathematics
Abstract

A clinical trial setting is considered in which two treatments are available for a particular ailment. The response to treatment is Bernoulli with “success” or “failure” as the outcome. Several allocation rules which are designed to reduce the number of patients who receive the inferior treatment are compared with random allocation using simulation. Particular attention is paid to the bias and variance for estimation of the true treatment difference. The effect of time trends in the data is examined.

Published
1992
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23. Sequential procedures for comparing several medical treatments

Author

J. A. Bather and D. S. Coad

Subjects
Statistics and Probability, Sequential estimation, Early stopping, Estimator, Standard deviation, Inverse Gaussian distribution, symbols.namesake, Sample size determination, Modeling and Simulation, Stopping time, Statistics, symbols, Bernoulli trial, Mathematics
Abstract

The use of sequential methods in clinical trials allows inferior treatments to be eliminated early. From an ethical point of view, the advantages are substantial. However, early stopping induces estimation bias and a deterioration in precision because of reduced sample sizes. This paper considers the problem of determining which of k ≥ 2 treatments with Bernoulli responses has the highest probability of success. Two sequential procedures are investigated and compared with a fixed—sample procedure. Various properties are derived and illustrated for the cases k =2,3 and 5. It is shown that the sequential procedures can achieve a pattern of error probabilities equivalent to the fixed—sample procedure for a much lower level of expected successes lost. Approximations for the bias and standard deviation of estimators of treatment differences are obtained by using results about the distribution of stopping times for a normal process.

Published
1992
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24. Sequential estimation with data-dependent allocation and time trends

Author

D. S. Coad

Subjects
Statistics and Probability, Independent and identically distributed random variables, Sequential estimation, Treatment difference, Time trends, Modeling and Simulation, Statistics, Sequential test, Time complexity, Data dependent, Independence (probability theory), Mathematics
Abstract

This note concerns the estimation of treatment difference following a sequential test in which two treatments are to be compared and treatment allocation is data-dependent. Woodroofe(1989) considered this problem when the responses are independent and identically distributed. In this paper, it is shown that woodroof'es asymptotic results also work well for the modified sequential test of coad (1991), which allows for possible linear time trends in the data.

Published
1991
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25. Sequential tests for an unstable response variable

Author

D. S. Coad

Subjects
Statistics and Probability, Independent and identically distributed random variables, Applied Mathematics, General Mathematics, Autocorrelation, Sequential test, Agricultural and Biological Sciences (miscellaneous), Correlation, Distribution (mathematics), Statistics, Statistics, Probability and Uncertainty, General Agricultural and Biological Sciences, Algorithm, Mathematics, Variable (mathematics)
Abstract

SUMMARY The class of sequential tests investigated by Robbins & Siegmund (1974) for deciding which of two treatments is superior is considered. For normal responses, it is shown how these tests can be modified to take into account linear time-trends in the data or serial correlation between responses. A number of allocation rules designed to reduce the number of patients who receive the inferior treatment are compared. Simulation indicates that the error probabilities for the modified tests are generally no larger than those for the original tests with independent and identically distributed responses.

Published
1991
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26. Corrected confidence intervals for secondary parameters following sequential tests

Author

Ruby C. Weng and D. S. Coad

Subjects
62E20, 65L10, Covariance matrix, coverage probability, posterior distribution, Mathematics - Statistics Theory, Multivariate normal distribution, Statistics Theory (math.ST), Pivotal quantity, Confidence interval, bivariate normal process, approximately pivotal quantity, very weak expansion, 62L05, Sampling distribution, Bivariate data, Simple (abstract algebra), Component (UML), FOS: Mathematics, Applied mathematics, Stein's identity, 62F25, 62E20, 62F25, 62L05, 65L10 (Primary), Mathematics
Abstract

Corrected confidence intervals are developed for the mean of the second component of a bivariate normal process when the first component is being monitored sequentially. This is accomplished by constructing a first approximation to a pivotal quantity, and then using very weak expansions to determine the correction terms. The asymptotic sampling distribution of the renormalised pivotal quantity is established in both the case where the covariance matrix is known and when it is unknown. The resulting approximations have a simple form and the results of a simulation study of two well-known sequential tests show that they are very accurate. The practical usefulness of the approach is illustrated by a real example of bivariate data. Detailed proofs of the main results are provided., Comment: Published at http://dx.doi.org/10.1214/074921706000000617 in the IMS Lecture Notes--Monograph Series (http://www.imstat.org/publications/lecnotes.htm) by the Institute of Mathematical Statistics (http://www.imstat.org)

Published
2006

28. Neurocomputed model of open-circuited coaxial probes

Author

S. Coad and D. Tuck

Subjects
Permittivity, Engineering, Observational error, Artificial neural network, Coaxial cable, business.industry, Acoustics, General Engineering, Feed forward, General Physics and Astronomy, law.invention, law, Electronic engineering, Feedforward neural network, Reflection coefficient, Coaxial, business
Abstract

An artificial multi-layered feedforward neural network has been developed which transforms reflection coefficient data measured using a coaxial probe and network analyser, into the permittivity values of the fluid the probe touches. This eliminates the need for de-embedding of data from the measurement plane via empirical models of the physical cable. Back propagation training and testing was performed on a 0.25 in. diameter coaxial probe, using data spanning the frequency range 200 MHz-16 GHz taken on nine fluids. The successful results indicate that a new nonparametric technique can join the other permittivity measurement schemes for coaxial probes. >

Published
1995
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29. A-66 * The Relationship between Scores on the MMPI-2 and Driving Simulator Skills

Author

Charles J. Golden, S. Coad, S Yassin, K. Spengler, and C. Babika

Subjects
media_common.quotation_subject, Driving simulator, Poison control, Human factors and ergonomics, Regression analysis, General Medicine, Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, Minnesota Multiphasic Personality Inventory, Injury prevention, Personality, Big Five personality traits, Psychology, Social psychology, Clinical psychology, media_common
Abstract

OBJECTIVE: The researcher examined the relationship between clinical scale scores on the MMPI-2 and the total amount of driving errors made on a driving simulator in male and female adults. METHOD: The sample consisted of 155 (male: n = 61 and female: n = 94) adults (mean age = 29.94, SD = 13.26; mean education = 15.44, SD = 2.09; 64.5% Caucasian; 14.8% Hispanic/Latino; 14.8% African-American). The data were derived from an ongoing de-identified database of clinical patients and student volunteers. All of the Clinical scales on the MMPI-2 and the total amount of driving errors were examined. RESULTS: A regression analysis was conducted between the MMPI-2 Clinical scales scores and the total driving errors that occurred on the driving simulator. RESULTS of this analysis were considered significant at the p CONCLUSION(S): Clinical scale 4, which measures anti-authority and abuse tendencies was a significant predictor of total driving errors made on the simulator. This result could be due to the fact that those who have an elevated scale 4 score tend to dislike authority and make decisions/rules for themselves, because they believe they are more qualified to do so than others. It is possible that those who carry this personality trait tend to get into risky driving situations. Although some of these results were significant, further research is still needed. Language: en

Published
2014
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30. C-07 * SPECT Imaging in Adults with Nicotine-Related Disorders

Author

Daniel Amen, M Blose, K Willeumier, Derek Taylor, Charles J. Golden, and S Coad

Subjects
Cerebellum, medicine.diagnostic_test, Nicotinic Receptors, General Medicine, Single-photon emission computed tomography, Temporal lobe, Nicotine, Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, medicine.anatomical_structure, Cerebral blood flow, Vascular flow, medicine, Occipital lobe, Psychology, Neuroscience, medicine.drug
Published
2014
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31. Spin and orbital moments in itinerant magnets

Author

G. H. Lander, M. S. S. Brooks, P. J. Brown, R. Troć, A. Czopnik, P. Burlet, S. Coad, A. Hiess, Dariusz Kaczorowski, F. Boudarot, Institut Laue-Langevin (ILL), Magnétisme et Diffusion Neutronique (MDN), Modélisation et Exploration des Matériaux (MEM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département de Recherche Fondamentale sur la Matière Condensée (DRFMC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), JRC Institute for Transuranium Elements [Karlsruhe] (ITU ), European Commission - Joint Research Centre [Karlsruhe] (JRC), and Polish Academy of Sciences (PAN)

Subjects
Physics, Scattering amplitude, Momentum, Magnetization, Angular momentum, Ferromagnetism, Condensed matter physics, Neutron diffraction, General Physics and Astronomy, Antiferromagnetism, Condensed Matter::Strongly Correlated Electrons, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Spin (physics)
Abstract

Itinerant magnets with large orbital moments are uncommon. We show that UGa3 is such a material where the itinerant magnetism is carried by the 5f states. The definitive evidence comes from neutron diffraction measurements of the magnetization distribution, where a significant difference is observed in the momentum dependence of the scattering amplitude above and below TN. The change in the magnetization distribution when the antiferromagnetic order appears is due to the antiparallel coupling of large atomic 5f spin and orbital moments below TN, whereas above TN there is spin degeneracy and no disordered local moments.

Published
2001
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32. Sequential allocation involving several treatments

Author

D. S. Coad

Subjects
Sequential allocation, 62L05, Generalization, Probability of error, 62F07, 62L12, Statistics, 62L10, Estimator, Variance (accounting), Mathematics
Abstract

A clinical trial model is considered in which k > 2 treatments are compared and treatment allocation is data-dependent. A sequential procedure for determining the best treatment is investigated that is a natural generalization of the test for two treatments studied by Robbins and Siegmund (1974). It is shown by extensive simulation that the error probability for the procedure is insensitive to the data-dependent allocation rule used. The estimation formulae of Coad (1994) are shown to give good approximations to the bias and variance of estimators of treatment differences.

Published
1995
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33. PCP exposure for the Canadian general population: a multimedia analysis

Author

S, Coad and R C, Newhook

Subjects
Adult, Male, Air Pollutants, Canada, Pentachlorophenol, Adolescent, Infant, Newborn, Infant, Food Contamination, Environmental Exposure, Middle Aged, Child, Preschool, Humans, Soil Pollutants, Female, Child, Water Pollutants, Chemical, Aged
Abstract

Pentachlorophenol (PCP) is ubiquitous in the Canadian environment, as a result of the large quantities used in the wood preservation and wood protection industries. In the past decade, agricultural and wood protection applications of PCP in Canada have been sharply curtailed. A multimedia approach was used to update estimates of PCP exposure of the members of the general population in Canada, based on currently available information. A detailed review of PCP concentrations reported in air, water, foods, household dust, and soil was performed. PCP intake estimates for infants, toddlers, school-age children, and adults in Canada were calculated. Estimates were made for people with average intakes of air, water, foods, household dust, and soil, as well as for recreational anglers and aboriginal subsistence fishermen, who were expected to have higher intakes. The current estimated intake by all of these populations is well below the Acceptable Daily Intake (ADI) of 6 micrograms/kg bw/day. The average members of the general population have an estimated intake via all routes of 0.05 micrograms/kg bw/day; most exposure is calculated to occur via food (dairy products, grains and cereals and meats) and indoor air. Recreational anglers are estimated to be exposed to only marginally more PCP per day (roughly 2%) than the general population. In contrast, aboriginal subsistence fisherman, because of their very high consumption of fish and fish products, experience the highest exposure to PCP through food; their estimated intake of PCP is almost twice that of the general population.

Published
1992

34. Magnetic excitations in UGa3

Author

A. Czopnik, R. Troć, S. Coad, Dariusz Kaczorowski, Luigi Paolasini, G. H. Lander, N. Bernhoeft, P Dervenagas, and Arno Hiess

Subjects
Physics, Condensed matter physics, Spectrum (functional analysis), chemistry.chemical_element, Inelastic scattering, Uranium, Condensed Matter Physics, Inelastic neutron scattering, Electronic, Optical and Magnetic Materials, chemistry, Moment (physics), Atom, Antiferromagnetism, Condensed Matter::Strongly Correlated Electrons, Electrical and Electronic Engineering, Atomic physics, Excitation
Abstract

UGa3 behaves as an itinerant antiferromagnet with T N =67 K and an ordered moment of μ=0.7 μ B per uranium atom. In this paper we discuss the magnetic excitation spectrum investigated by inelastic neutron scattering. The spectrum can be described as a coupled system of two components: namely (i) a quasi-elastic and (ii) an inelastic response. The susceptibility of the quasi-elastic response exhibits an anomalous temperature dependence.

Published
2000
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35. Magnetism in R2T3X9 (R=Ce, Yb, U; T=Rh, Ir; X=Al, Ga) intermetallic compounds

Author

A. Hiess, Emmanuelle Suard, F. Givord, Frank Steglich, C. Geibel, S. Coad, T. Hansen, B. Buschinger, E. Lelièvre-Berna, J.-X. Boucherle, and O. Trovarelli

Subjects
Materials science, Magnetic structure, Magnetism, Neutron diffraction, Intermetallic, Neutron scattering, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Paramagnetism, Crystallography, Magnetization, Nuclear magnetic resonance, Electrical and Electronic Engineering, Isostructural
Abstract

The magnetic properties of the isostructural intermetallic compounds U2Ir3Al9, Yb2Ir3Al9 and Ce2Rh3Al9 have been examined using neutron diffraction. We discuss here the systematic changes in the magnetic structure and magnetisation density with respect to the changes in constituents. The U and the Yb compounds show the same magnetic order below TN(U)=18 K and TN(Yb)=5.6 K, while the induced magnetisation of the paramagnetic Ce compound is localised on the cerium ion.

Published
1999
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36. Applied Multivariate Data Analysis

Author

D. S. Coad, B. S. Everitt, and G. Dunn

Subjects
Statistics and Probability, Economics and Econometrics, Multivariate statistics, Multivariate analysis, Multivariate analysis of variance, Statistics, Statistics, Probability and Uncertainty, Psychology, Social Sciences (miscellaneous), Data matrix (multivariate statistics), Mathematics
Published
1993
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39. Neutron and synchrotron diffraction study of UPtGe

Author

José A. Paixão, Sean Langridge, S. Coad, Jean Rebizant, Yasuo Yamaguchi, D. Mannix, P. J. Brown, S. Kawamata, and G. H. Lander

Subjects
Crystal, Physics, Optics, Magnetic structure, Magnetic domain, business.industry, Neutron, Atomic physics, Photon energy, Type (model theory), business, Single crystal, Diffractometer
Abstract

UPtGe has an incommensurate and noncollinear magnetic structure. Neutron experiments on a single crystal have shown that the crystal structure is neither the TiNiSi nor disordered ${\mathrm{CeCu}}_{2}$ type, as previously suggested, but rather the noncentrosymmetric EuAuGe structure, with two independent uranium atoms in the asymmetric unit. We report details of the cycloidal magnetic structure as examined by a conventional diffractometer, and the neutron polarimeter at the Institut Laue Langevin. The uranium moments are different on the two sites, with the average value of $1.4{\ensuremath{\mu}}_{B}.$ A single magnetic domain exists and we believe this is a consequence of the noncentrosymmetric crystal structure. As a result the crystal produces a polarized beam of neutrons from an incident unpolarized beam. In resonant scattering experiments at the ID20 beamline of the ESRF the second-order magnetic satellite, which is a direct consequence of the cycloidal structure and the resonant cross section, was observed with the photon energy tuned to the uranium ${M}_{4}$ edge. The ratio of this to the first-order satellite is more than an order of magnitude less than that found in similar experiments on Ho. We have also observed weak resonant effects at the Pt ${L}_{3}$ and Ge K edges.

42. William Dunlap

Author

O. S. Coad

Subjects
Linguistics and Language, Literature and Literary Theory, Library and Information Sciences, Language and Linguistics
Published
1916
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44. Directive clinique n o 440 : Prise en charge de la grossesse gémellaire monochoriale.

Author

Lee HS, Abbasi N, Van Mieghem T, Mei-Dan E, Audibert F, Brown R, Coad S, Lewi L, Barrett J, and Ryan G

Abstract

Objectif: Cette directive clinique passe en revue les données probantes sur la prise en charge de la grossesse gémellaire monochoriale normale et compliquée., Population Cible: Les femmes menant une grossesse gémellaire ou multiple de haut rang. BéNéFICES, RISQUES ET COûTS: L'application des recommandations de cette directive devrait améliorer la prise en charge des grossesses gémellaires (ou multiples de haut rang) monochoriales compliquées et non compliquées. Ces recommandations aideront les fournisseurs de soins à surveiller adéquatement les grossesses gémellaires monochoriales ainsi qu'à détecter et prendre en charge rapidement les complications associées de façon optimale afin de réduire les risques de morbidité et mortalité périnatales. Ces recommandations impliquent une surveillance échographique plus fréquente en cas de grossesse monochoriale qu'en cas de grossesse bichoriale. DONNéES PROBANTES: La littérature publiée a été colligée par des recherches dans les bases de données PubMed et Cochrane Library au moyen de termes MeSH pertinents (Twins, Monozygotic; Ultrasonography, Prenatal; Placenta; Fetofetal Transfusion; Fetal Death; Fetal Growth Retardation). Les résultats ont été restreints aux revues systématiques, aux essais cliniques randomisés et aux études observationnelles. Aucune date limite n'a été appliquée, mais les résultats ont été limités aux contenus en anglais ou en français. MéTHODES DE VALIDATION: Les auteurs principaux ont rédigé le contenu et les recommandations et ils se sont entendus sur ces derniers. Le conseil d'administration de la SOGC a approuvé la version définitive aux fins de publication. Les auteurs ont évalué la qualité des données probantes et la force des recommandations en utilisant le cadre méthodologique GRADE (Grading of Recommendations Assessment, Development and Evaluation). Voir l'annexe A en ligne (tableau A1 pour les définitions et tableau A2 pour l'interprétation des recommandations fortes et conditionnelles [faibles]). PROFESSIONNELS CONCERNéS: Spécialistes en médecine fœto-maternelle, obstétriciens, radiologues, échographistes, médecins de famille, infirmières, sages-femmes, résidents et autres fournisseurs de soins de santé qui s'occupent de femmes menant une grossesse gémellaire ou multiple de haut rang. RéSUMé POUR TWITTER: Directive canadienne (SOGC) pour le diagnostic, la surveillance échographique et la prise en charge des complications de la grossesse gémellaire monochoriale (p. ex., STT, TAPS, retard de croissance sélectif, cojumeau acardiaque, monoamnionicité et mort d'un jumeau). DÉCLARATIONS SOMMAIRES: RECOMMANDATIONS., (Copyright © 2023. Published by Elsevier Inc.)

Published
2023
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45. Guideline No. 440: Management of Monochorionic Twin Pregnancies.

Author

Lee HS, Abbasi N, Van Mieghem T, Mei-Dan E, Audibert F, Brown R, Coad S, Lewi L, Barrett J, and Ryan G

Subjects
Pregnancy, Female, Humans, Twins, Monozygotic, Ultrasonography, Prenatal adverse effects, Canada, Fetal Death, Fetal Growth Retardation epidemiology, Pregnancy, Twin, Fetofetal Transfusion diagnosis
Abstract

Objective: This guideline reviews the evidence-based management of normal and complicated monochorionic twin pregnancies., Target Population: Women with monochorionic twin or higher order multiple pregnancies., Benefits, Harms, and Costs: Implementation of these recommendations should improve the management of both complicated and uncomplicated monochorionic (and higher order multiple) twin pregnancies. They will help users monitor monochorionic twin pregnancies appropriately and identify and manage monochorionic twin complications optimally in a timely manner, thereby reducing perinatal morbidity and mortality. These recommendations entail more frequent ultrasound monitoring of monochorionic twins compared to dichorionic twins., Evidence: Published literature was retrieved through searches of PubMed and the Cochrane Library using appropriate MeSH headings (Twins, Monozygotic; Ultrasonography, Prenatal; Placenta; Fetofetal Transfusion; Fetal Death; Fetal Growth Retardation). Results were restricted to systematic reviews, randomized controlled clinical trials, and observational studies. There were no date limits, but results were limited to English or French language materials., Validation Methods: The content and recommendations were drafted and agreed upon by the principal authors. The Board of the SOGC approved the final draft for publication. The authors rated the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. See online Appendix A (Tables A1 for definitions and A2 for interpretations of strong and conditional [weak] recommendations)., Intended Audience: Maternal-fetal medicine specialists, obstetricians, radiologists, sonographers, family physicians, nurses, midwives, residents, and other health care providers who care for women with monochorionic twin or higher order multiple pregnancies., Tweetable Abstract: Canadian (SOGC) guidelines for the diagnosis, ultrasound surveillance and management of monochorionic twin pregnancy complications, including TTTS, TAPS, sFGR (sIUGR), acardiac (TRAP), monoamniotic twins and intrauterine death of one MC twin., Summary Statements: RECOMMENDATIONS., (Copyright © 2023. Published by Elsevier Inc.)

Published
2023
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46. Temporal trends in severe maternal and neonatal trauma during childbirth: a population-based observational study.

Author

Wen Q, Muraca GM, Ting J, Coad S, Lim KI, and Lisonkova S

Subjects
Adolescent, Adult, Birth Injuries epidemiology, Cesarean Section, Delivery, Obstetric methods, Delivery, Obstetric trends, Female, Humans, Infant, Newborn, Lacerations, Logistic Models, Obstetrical Forceps, Perineum injuries, Pregnancy, Prevalence, Retrospective Studies, Risk Factors, Vagina, Washington epidemiology, Wounds and Injuries epidemiology, Young Adult, Delivery, Obstetric adverse effects, Infant Health trends, Maternal Health trends, Obstetric Labor Complications epidemiology, Wounds and Injuries etiology
Abstract

Objective: Instrumental vaginal delivery is associated with birth trauma to infant and obstetric trauma to mother. As caesarean delivery rates increased during the past decades, the rate of instrumental vaginal delivery declined. We examined concomitant temporal changes in the rates of severe birth trauma and maternal obstetric trauma., Design: A retrospective observational study., Settings and Participants: All hospital singleton live births in Washington State, USA, 2004-2013, excluding breech delivery. Severe birth trauma (brain, nerve injury, fractures and other severe birth trauma) and obstetric trauma (third/fourth degree perineal lacerations, cervical/high vaginal lacerations) were identified from hospitalisation data. Pregnancy and delivery characteristics were obtained from birth certificates. Temporal trends were assessed by the Cochran-Armitage test. Logistic regression was used to obtain adjusted ORs (AORs) and 95% CI., Results: Overall, 732 818 live births were included. The rate of severe birth trauma declined from 5.3 in 2004 to 4.5 per 1000 live births in 2013 (P<0.001). The decline was observed only in spontaneous vaginal delivery, the rates of fractures and other severe birth trauma declined by 5% and 4% per year, respectively (AOR: 0.95, 95% CI 0.94 to 0.97 and AOR: 0.96, 95% CI 0.93 to 0.99; respectively). The rate of third/fourth degree lacerations declined in spontaneous vaginal delivery from 3.5% to 2.3% (AOR: 0.95; 95% CI 0.94 to 0.95) and in vacuum delivery from 17.3% to 14.5% (AOR: 0.97, 95% CI 0.96 to 0.98). Among women with forceps delivery, these rates declined from 29.8% to 23.4% (AOR: 0.98, 95% CI 0.96 to 1.00)., Conclusion: While the rates of fractures and other birth trauma declined among infants delivered by spontaneous vaginal delivery, the rate of birth trauma remained unchanged in instrumental vaginal delivery and caesarean delivery. Among mothers, the rates of severe perineal lacerations declined, except for women with forceps delivery., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)

Published
2018
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47. Seasonal Analysis of Mucosal Immunological Function and Physical Demands in Professional Australian Rules Footballers.

Author

Coad S, Gray B, and McLellan C

Subjects
Adult, Australia, Humans, Male, Young Adult, Athletes, Football, Immunoglobulin A metabolism, Saliva metabolism
Abstract

Purpose: To assess match-to-match variations in salivary immunoglobulin A concentration ([s-IgA]) measured at 36 h postmatch throughout an Australian Football League (AFL) premiership season and to assess the trends between 36-h-postmatch [s-IgA] and match-play exercise workloads throughout the same season., Methods: Eighteen elite male AFL athletes (24 ± 4.2 y, 187.0 ± 7.1 cm, 87.0 ± 7.6 kg) were monitored on a weekly basis to determine total match-play exercise workloads and 36-h-postmatch [s-IgA] throughout 16 consecutive matches in an AFL premiership season. Global positioning systems (GPS) with integrated triaxial accelerometers were used to measure exercise workloads (PlayerLoad) during each AFL match. A linear mixed-model analyses was conducted for time-dependent changes in [s-IgA] and player load., Results: A significant main effect was found for longitudinal postmatch [s-IgA] data (F16,240 = 3.78, P < .01) and PlayerLoad data (F16,66 = 1.98, P = .03). For all matches after and including match 7, a substantial suppression trend in [s-IgA] 36-h-postmatch values was found compared with preseason baseline [s-IgA]., Conclusion: The current study provides novel data regarding longitudinal trends in 36-h-postmatch [s-IgA] for AFL athletes. Results demonstrate that weekly in-season AFL match-play exercise workloads may result in delayed mucosal immunological recovery beyond 36 h postmatch. The inclusion of individual athlete-monitoring strategies of [s-IgA] may be advantageous in the detection of compromised postmatch mucosal immunological function for AFL athletes.

Published
2016
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48. Physical demands and salivary immunoglobulin A responses of elite Australian rules football athletes to match play.

Author

Coad S, Gray B, Wehbe G, and McLellan C

Subjects
Adult, Australia, Humans, Male, Mouth Mucosa immunology, Young Adult, Athletes, Immunoglobulin A metabolism, Saliva metabolism, Soccer physiology
Abstract

Purpose: To examine the response or pre- and postmatch salivary immunoglobulin A concentration ([s-IgA]) to Australian Football League (AFL) match play and investigate the acute and cumulative influence of player workload and postmatch [s-IgA] after repeated participation in AFL match play., Methods: Eleven elite AFL athletes (21.8±2.4 y, 186.9±7.9 cm, 87.4±7.5 kg) were monitored throughout 3 matches during the preseason that were separated by 7 d. Saliva samples were collected across each AFL match at 24 h and 1 h prematch and 1, 12, 36, and 60 h postmatch to determine [s-IgA]. Global positioning systems (GPS) with integrated triaxial accelerometers were used to determine total player workload during match play. Hypothesis testing was conducted for time-dependent changes in [s-IgA] and player load using a repeated-measures ANOVA., Results: Player load during match 3 (1266±124.6 AU) was significantly (P<.01) greater than in match 1 (1096±115.1 AU) and match 2 (1082±90.4 AU). Across match 3, [s-IgA] was significantly (P<.01) suppressed at 2 postmatch measures (12 and 36 h) compared with prematch measures (24 and 1 h), which coincided with significantly (P<.01) elevated player load., Conclusion: The findings indicate that an increase in player load during AFL preseason match play resulted in compromised postmatch mucosal immunological function. Longitudinal assessment of AFL-match player load and mucosal immunological function across the first 60 h of recovery may augment monitoring and preparedness strategies for athletes.

Published
2015
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49. Monitoring neuromuscular fatigue in team-sport athletes using a cycle-ergometer test.

Author

Wehbe G, Gabett TJ, Dwyer D, McLellan C, and Coad S

Subjects
Adolescent, Athletic Performance physiology, Humans, Male, Plyometric Exercise, Running physiology, Time Factors, Exercise Test methods, Muscle Fatigue physiology, Soccer physiology
Abstract

Purpose: To compare a novel sprint test on a cycle ergometer with a countermovement-jump (CMJ) test for monitoring neuromuscular fatigue after Australian rules football match play., Methods: Twelve elite under-18 Australian rules football players (mean ± SD age 17.5 ± 0.6 y, stature 184.7 ± 8.8 cm, body mass 75.3 ± 7.8 kg) from an Australian Football League club's Academy program performed a short sprint test on a cycle ergometer along with a single CMJ test 1 h prematch and 1, 24, and 48 h postmatch. The cycle-ergometer sprint test involved a standardized warm-up, a maximal 6-s sprint, a 1-min active recovery, and a 2nd maximal 6-s sprint, with the highest power output of the 2 sprints recorded as peak power (PP)., Results: There were small to moderate differences between postmatch changes in cycle-ergometer PP and CMJ PP at 1 (ES = 0.49), 24 (ES = -0.85), and 48 h postmatch (ES = 0.44). There was a substantial reduction in cycle-ergometer PP at 24 h postmatch (ES = -0.40) compared with 1 h prematch., Conclusions: The cycle-ergometer sprint test described in this study offers a novel method of neuromuscular-fatigue monitoring in team-sport athletes and specifically quantifies the concentric component of the fatigue-induced decrement of force production in muscle, which may be overlooked by a CMJ test.

Published
2015
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50. Validity and reliability of a novel salivary immunoassay for individual profiling in applied sports science.

Author

Coad S, Mclellan C, Whitehouse T, and Gray B

Subjects
Adult, Chromatography, Affinity instrumentation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoassay methods, Male, Reproducibility of Results, Sports Medicine, Young Adult, Chromatography, Affinity methods, Immunoglobulin A analysis, Saliva chemistry
Abstract

The aim of this study was to examine the validity and reliability of a novel immunoassay, developed to assess salivary Immunoglobulin A (s-IgA). Validity and reliability of the Individual Profiling Lateral Flow Device (IPRO LFD) for s-IgA concentrations ([s-IgA]) was assessed in males (n = 12) and females (n =13) who were involved in recreational activities. Reliability of the IPRO LFD method was assessed by comparing [s-IgA] of two saliva samples collected concurrently, while validity was assessed by comparing with an enzyme-linked immunosorbent assay (ELISA) method. The IPRO LFD had a strong positive correlation (r = 0.93, p < 0.001), with no difference in [s-IgA] compared with the ELISA. The IPRO LFD was considered reliable (ICC r = 0.89, p < 0.001 and CV = 9.40 %) for measures of [s-IgA]. We concluded that the IPRO LFD method may be a substitute to the ELISA method for measurements of [s-IgA].

Published
2015
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