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2. Response to Tyrosine Kinase Inhibitors in Real-World Patients With Chronic Myeloid Leukemia

Author

Andy H. Szeto, Majd Ahmad, Matthew C. Foster, Margaret R Sketch, Joshua F. Zeidner, Anqi Zhu, Tyler Bucci, Ryan Kemper, Benyam Muluneh, Daniel J. Crona, Amanda S Cass, and Allison M. Deal

Subjects
business.industry, Dasatinib, Myeloid leukemia, Imatinib, Clinical trial, Treatment Outcome, Nilotinib, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Imatinib Mesylate, Cancer research, Humans, Medicine, Pharmacology (medical), business, Protein Kinase Inhibitors, Tyrosine kinase, Bosutinib, medicine.drug
Abstract

Background: Tyrosine kinase inhibitors (TKIs) are the front-line therapy for chronic myeloid leukemia (CML), where phase 3 clinical trials have demonstrated their safety and efficacy. However, trial patients may not be representative of real-world patients (RWPs). Objective: To evaluate RWP clinical factors associated with effectiveness and safety in CML patients treated with TKIs. Methods: Patients with CML treated with at least 30 days of imatinib, dasatinib, nilotinib, or bosutinib between 2014 and 2018 were included. Patients were stratified into categories based on the number of factors that would have precluded enrollment into pivotal TKI phase 3 trials (0, 1, ≥2). End points included complete hematologic response (CHR), early molecular response (EMR), major molecular response (MMR), adverse event (AE)-induced dose decreases, treatment interruptions, and treatment discontinuations. Results: Final analyses included 174 patients. Patients with ≥2 factors had a higher risk of dose decreases (relative risk = 1.54; 95% CI = 1.02-2.34; P = 0.02) and a shorter time to dose decrease (hazard ratio = 2.43; 95% CI = 1.23-4.97; P = 0.006) compared with patients with 0 factors. Significant differences were observed in CHR at 1 month and MMR at 3 months between patients with 0 and ≥2 factors ( P = 0.03 and P = 0.04, respectively). Conclusion and Relevance: Approximately 60% of our RWPs would have been excluded from the pivotal phase 3 TKI trials. These data suggest that RWPs require more precise dosing to achieve CML clinical milestones and to mitigate AEs, but findings should be validated prospectively.

Published
2021
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3. Slavery, economics, race and convict leasing: A general and materialist history of punishment and prisons in Florida, 1840-1923

Author

Elizabeth S. Cass and Michael J. Lynch

Subjects
History, Sociology and Political Science, Social Psychology, Punishment, media_common.quotation_subject, Social environment, Convict, Criminology, Archival research, Trace (semiology), Race (biology), Materialism, Law, media_common
Abstract

This paper employs archival data and historical analysis to trace Florida’s penal history, and to connect that history to the economic and social context of the time. Section I reviews the history ...

Published
2021
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5. Stratified follow up for endometrial cancer according to the characteristics of a tumour

Author

Katy Horton Fawkes, Vivek Nama, Gemma K S Cass, Jo Bailey, and Amit Patel

Subjects
Oncology, medicine.medical_specialty, Cost effectiveness, business.industry, Endometrial cancer, Cancer, Disease, medicine.disease, Obstetrics and gynaecology, Internal medicine, medicine, Post treatment, business, Medical science
Abstract

We explore cost effectiveness and the role of tumour characteristics to stratify women for follow up with endometrial cancer, A risk stratified pathway of post treatment management for women with endometrial cancer is necessary. Grade 3 disease and presence of LVSI may be risk factors for death and recurrence of endometrial cancer that can help to stratify women for follow up. Keywords: Endometrial cancer, Follow up, Cost effectiveness, Survivorship, Recurrence.

Published
2019
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6. Lung Cancer E-Book : An Evidence-Based Approach to Multidisciplinary Management

Author

Erin Alexis Gillaspie, Leora Horn, Amanda S. Cass, Erin Alexis Gillaspie, Leora Horn, and Amanda S. Cass

Subjects
Lungs--Cancer
Abstract

Care of the lung cancer patient—screening, diagnosis, and treatment—has undergone recent dramatic changes due to technologic and research-driven advances. Lung Cancer: An Evidence-Based Approach to Multidisciplinary Management covers every aspect of this fast-changing field, including new screening guidelines, new practice standards, and new treatment advances that have led to higher survival rates. This practical, clinically oriented resource provides thorough, evidence-based coverage from experts in the field, including the increasingly important precision medicine approach in lung cancer planning and management. - Discusses key topics such as small cell and non-small cell lung cancers; immunotherapy, molecular cohorts including ROS1, BRAF, HER2, Met, and NTRK; oligometastatic disease; and more. - Covers individualized treatment plans for chemotherapy, radiotherapy, targeted biomarker-derived therapies, and new and emerging immunotherapies. - Provides excellent visual guidance throughout, including algorithms, pathology specimens, anatomic drawings, and PET/CT and CT imaging for diagnosis and treatment planning. - Features'Top 5 Clinical Pearls at the beginning of each chapter. - Shares the experience and knowledge of medical oncologists, radiation oncologists, surgical oncologists, and thoracic radiologists for a real-world tumor board perspective.

Published
2023

8. Current Landscape of Personalized Therapy

Author

Amanda S. Cass and Leora Horn

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Disease, Systemic therapy, B7-H1 Antigen, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Carcinoma, Non-Small-Cell Lung, Anaplastic lymphoma kinase, Medicine, Humans, Epidermal growth factor receptor, Molecular Targeted Therapy, Precision Medicine, Lung cancer, Chemotherapy, biology, business.industry, Immunotherapy, medicine.disease, 030228 respiratory system, Pharmacogenetics, 030220 oncology & carcinogenesis, Toxicity, biology.protein, Surgery, business
Abstract

Almost a half of patients diagnosed with nonesmall-cell lung cancer (NSCLC) present with incurable disease, and a significant number of patients who are treated with curative intent for early-stage disease will eventually recur. Systemic therapy is selected based on tumor histology, squamous versus nonsquamous NSCLC, molecular testing, and PD-L1 score. Depending on PD-L1 score, patients are eligible for immunotherapy alone or in combination with chemotherapy in the first-line setting. Oncogenic driver mutations can be detected in approximately 50% of patients with nonsquamous NSCLC of which several can be targeted therapeutically with small molecular inhibitors. Continued research is needed for more specific agents with less toxicity and better central nervous system penetration, and agents to treat patients who develop resistance against targeted treatments and immunotherapy.

Published
2020

9. Analysis of Opioid Use Following Curative Cancer Treatment at a Large Urban Safety-net Hospital

Author

Joyce T. Alese, Chaejin Kim, Olatunji B. Alese, Amanda S Cass, Zhengjia Chen, Marjorie Adams Curry, and Jennifer Ann LaFollette

Subjects
Adult, Male, medicine.medical_specialty, Multivariate analysis, 03 medical and health sciences, symbols.namesake, Hospitals, Urban, 0302 clinical medicine, Risk Factors, Neoplasms, Internal medicine, medicine, Humans, 030212 general & internal medicine, Medical prescription, Fisher's exact test, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Cancer, Retrospective cohort study, Odds ratio, Middle Aged, Opioid-Related Disorders, medicine.disease, Confidence interval, Analgesics, Opioid, Anesthesiology and Pain Medicine, Opioid, 030220 oncology & carcinogenesis, symbols, Female, Neurology (clinical), business, medicine.drug
Abstract

OBJECTIVES This study examined the pattern of use and factors predicting prolonged prescription opioid medications among cancer patients following treatment with curative intent. MATERIALS AND METHODS Patients diagnosed with cancer over a 3-year period at a large urban safety-net hospital were included. Univariate and multivariate analyses was used to identify factors associated with continued opioid use. RESULTS Of the 199 patients included in the study, 38% continued to receive an opioid prescription well beyond the acute diagnosis and treatment phase. Mean age was 60.3 years, with a female preponderance (63%). Surgical resection only (31.6%) and the combination of surgery, chemotherapy, and radiation (19.7%) were the commonest treatment modalities. Pain-related comorbidities predating cancer diagnosis were reported in 53.3% of the patients, and about 33% were also on pain-modifying medications (odds ratio [OR], 3.58; 95% confidence interval [CI], 1.92-6.77; Fisher exact test P

Published
2018
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10. Twitter helped me decide that I'm not for resuscitation

Author

Keith S Cass

Subjects
Male, Resuscitation, Palliative care, Attitude to Death, Personal narrative, Decision Making, Palliative Care, MEDLINE, Prostatic Neoplasms, General Medicine, Professional-Patient Relations, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Nursing, Health Communication, Humans, Social media, Family, 030212 general & internal medicine, Resuscitation Decisions, Psychology, Health communication, Social Media, Resuscitation Orders
Abstract

Discussions about your death will never be easy, but Keith Cass describes how social media was useful to him when thinking and talking about resuscitation decisions

Published
2018

13. How to Fight Crime in Real Time

Author

W. Sweet and S. Cass

Subjects
Software deployment, Law administration, Control (management), Terrorism, Criminal law, Business, Electrical and Electronic Engineering, Computer security, computer.software_genre, computer
Abstract

This paper presents an integrated databases and central control centre that enable New York City's police to cut reaction times and speed investigations. The same system can also be used to counter any immediate terrorist threat, though the city's counterterrorism operation emphasizes intelligent deployment of personnel and resources, not technology as such

Published
2007
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14. Careers: Where the Jobs Are

Author

S. Cass

Subjects
Work (electrical), Human resource management, Staffing, Profit margin, Economics, Tracking (education), Electrical and Electronic Engineering, Marketing, Commoditization, Investment (macroeconomics), Management
Abstract

IEEE Spectrum teamed up with The New York Times to survey 752 IEEE members about the past, present, and future technological trends they are seeing. Rather than looking at industry statistics such as sales or market values, this paper focused on tracking research and development efforts across 19 technological areas as well as academia. This focus was chosen because, apart from the fact that R&D is specifically the work many engineers do to earn their living, R&D staffing and spending act as a general bellwether: declining investment in R&D typically indicates an area that isn't set for high growth or is experiencing commoditization of its products and the attendant squeezing of profit margins

Published
2007
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15. The FUEL code project

Author

S. Cass Ave, James C. Osborn, and Argonne Leadership Computing Facility

Subjects
Development (topology), Computer science, business.industry, Scripting language, Lattice field theory, Code (cryptography), Gauge theory, Software engineering, business, computer.software_genre, computer, Simulation, Standard model (cryptography)
Abstract

We give an introduction to the FUEL project for lattice field theory code. The code being developed (called “qhmc”) was initially targeted for gauge field generation for beyond standard model theories, and is now growing into a more general framework suitable for analysis too. The design is based on using the Lua scripting language as a wrapper for existing lattice field theory libraries, which provides a quick and easy way to develop new calculations. The implementation currently only supports the USQCD QOPQDP and QDP/C libraries, with support for other optimized libraries planned. We will discuss the current status of the code along with future plans for development.

Published
2015
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16. Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer

Author

Jo Morrison, Andrew Bryant, Gemma K S Cass, Alison J Wiggans, and Theresa A Lawrie

Subjects
Oncology, Adult, Medicine General & Introductory Medical Sciences, medicine.medical_specialty, Veliparib, DNA Repair, Antineoplastic Agents, Carcinoma, Ovarian Epithelial, Poly(ADP-ribose) Polymerase Inhibitors, Disease-Free Survival, Piperazines, law.invention, Olaparib, chemistry.chemical_compound, Randomized controlled trial, law, Internal medicine, medicine, Humans, Pharmacology (medical), Randomized Controlled Trials as Topic, Gynecology, Ovarian Neoplasms, business.industry, Hazard ratio, Cancer, Debulking, medicine.disease, chemistry, PARP inhibitor, Phthalazines, Benzimidazoles, Female, Neoplasm Recurrence, Local, Poly(ADP-ribose) Polymerases, Ovarian cancer, business
Abstract

BACKGROUND: Ovarian cancer is the sixth most common cancer in women world‐wide. Epithelial ovarian cancer (EOC) is the most common; three‐quarters of women present when disease has spread outside the pelvis (stage III or IV). Treatment consists of a combination of surgery and platinum‐based chemotherapy. Although initial responses to chemotherapy are good, most women with advanced disease will relapse. PARP (poly (ADP‐ribose) polymerase) inhibitors (PARPi), are a type of anticancer treatment that works by preventing cancer cells from repairing DNA damage, especially in those with breast cancer susceptibility gene (BRCA) variants. PARPi offer a different mechanism of anticancer treatment from conventional chemotherapy. OBJECTIVES: To determine the benefits and risks of poly (ADP‐ribose) polymerase) inhibitors (PARPi) for the treatment of epithelial ovarian cancer (EOC). SEARCH METHODS: We identified randomised controlled trials (RCTs) by searching the Cochrane Central Register of Controlled Trials (Central 2020, Issue 10), Cochrane Gynaecological Cancer Group Trial Register, MEDLINE (1990 to October 2020), Embase (1990 to October 2020), ongoing trials on www.controlled-trials.com/rct, www.clinicaltrials.gov, www.cancer.gov/clinicaltrials, the National Research Register (NRR), FDA database and pharmaceutical industry biomedical literature. SELECTION CRITERIA: We included trials that randomised women with EOC to PARPi with no treatment, or PARPi versus conventional chemotherapy, or PARPi together with conventional chemotherapy versus conventional chemotherapy alone. DATA COLLECTION AND ANALYSIS: We used standard Cochrane methodology. Two review authors independently assessed whether studies met the inclusion criteria. We contacted investigators for additional data. Outcomes included overall survival (OS), objective response rate (ORR), quality of life (QoL) and rate of adverse events. MAIN RESULTS: We included 15 studies (6109 participants); four (3070 participants) with newly‐diagnosed, advanced EOC and 11 (3039 participants) with recurrent EOC. The studies varied in types of comparisons and evaluated PARPi. Eight studies were judged as at low risk of bias in most of the domains. Quality of life data were generally poorly reported. Below we present six key comparisons. The majority of participants had BRCA mutations, either in their tumour (sBRCAmut) and/or germline (gBRCAmut), or homologous recombination deficiencies (HRD) in their tumours. Newly diagnosed EOC Overall, four studies evaluated the effect of PARPi in newly‐diagnosed, advanced EOC. Two compared PARPi with chemotherapy and chemotherapy alone. OS data were not reported. The combination of PARPi with chemotherapy may have little to no difference in progression‐free survival (PFS) (two studies, 1564 participants; hazard ratio (HR) 0.82, 95% confidence interval (CI 0).49 to 1.38; very low‐certainty evidence)(no evidence of disease progression at 12 months' 63% with PARPi versus 69% for placebo). PARPi with chemotherapy likely increases any severe adverse event (SevAE) (grade 3 or higher) slightly (45%) compared with chemotherapy alone (51%) (two studies, 1549 participants, risk ratio (RR) 1.13, 95% CI 1.07 to 1.20; high‐certainty evidence). PARPi combined with chemotherapy compared with chemotherapy alone likely results in little to no difference in the QoL (one study; 744 participants, MD 1.56 95% CI ‐0.42 to 3.54; moderate‐certainty evidence). Two studies compared PARPi monotherapy with placebo as maintenance after first‐line chemotherapy in newly diagnosed EOC. PARPi probably results in little to no difference in OS (two studies, 1124 participants; HR 0.81, 95%CI 0.59 to 1.13; moderate‐certainty evidence) (alive at 12 months 68% with PARPi versus 62% for placebo). However, PARPi may increase PFS (two studies, 1124 participants; HR 0.42, 95% CI 0.19 to 0.92; low‐certainty evidence) (no evidence of disease progression at 12 months' 55% with PARPi versus 24% for placebo). There may be an increase in the risk of experiencing any SevAE (grade 3 or higher) with PARPi (54%) compared with placebo (19%)(two studies, 1118 participants, RR 2.87, 95% CI 1.65 to 4.99; very low‐certainty evidence), but the evidence is very uncertain. There is probably a slight reduction in QoL with PARPi, although this may not be clinically significant (one study, 362 participants; MD ‐3.00, 95%CI ‐4.48 to ‐1.52; moderate‐certainty evidence). Recurrent, platinum‐sensitive EOC Overall, 10 studies evaluated the effect of PARPi in recurrent platinum‐sensitive EOC. Three studies compared PARPi monotherapy with chemotherapy alone. PARPi may result in little to no difference in OS (two studies, 331 participants; HR 0.95, 95%CI 0.62 to 1.47; low‐certainty evidence) (percentage alive at 36 months 18% with PARPi versus 17% for placebo). Evidence is very uncertain about the effect of PARPi on PFS (three studies, 739 participants; HR 0.88, 95%CI 0.56 to 1.38; very low‐certainty evidence)(no evidence of disease progression at 12 months 26% with PARPi versus 22% for placebo). There may be little to no difference in rates of any SevAE (grade 3 or higher) with PARPi (50%) than chemotherapy alone (47%) (one study, 254 participants; RR 1.06, 95%CI 0.80 to 1.39; low‐certainty evidence). Four studies compared PARPi monotherapy as maintenance with placebo. PARPi may result in little to no difference in OS (two studies, 560 participants; HR 0.88, 95%CI 0.65 to 1.20; moderate‐certainty evidence)(percentage alive at 36 months 21% with PARPi versus 17% for placebo). However, evidence suggests that PARPi as maintenance therapy results in a large PFS (four studies, 1677 participants; HR 0.34, 95% CI 0.28 to 0.42; high‐certainty evidence)(no evidence of disease progression at 12 months 37% with PARPi versus 5.5% for placebo). PARPi maintenance therapy may result in a large increase in any SevAE (51%) (grade 3 or higher) than placebo (19%)(four studies, 1665 participants, RR 2.62, 95%CI 1.85 to 3.72; low‐certainty evidence). PARPi compared with chemotherapy may result in little or no change in QoL (one study, 229 participants, MD 1.20, 95%CI ‐1.75 to 4.16; low‐certainty evidence). Recurrent, platinum‐resistant EOC Two studies compared PARPi with chemotherapy. The certainty of evidence in both studies was graded as very low. Overall, there was minimal information on the QoL and adverse events. AUTHORS' CONCLUSIONS: PARPi maintenance treatment after chemotherapy may improve PFS in women with newly‐diagnosed and recurrent platinum‐sensitive EOC; there may be little to no effect on OS, although OS data are immature. Overall, this is likely at the expense of an increase in SevAE. It is disappointing that data on quality of life outcomes are relatively sparse. More research is needed to determine whether PARPi have a role to play in platinum‐resistant disease.

Published
2015

17. Tools & Toys: Hardware for your Software Radio

Author

S. Cass

Subjects
Hardware architecture, Collaborative software, Resource-oriented architecture, Computer science, business.industry, Software construction, Component-based software engineering, Software system, Software-defined radio, Electrical and Electronic Engineering, Field-programmable gate array, business, Software engineering
Published
2006
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18. Invention: The Idea man

Author

S. Cass

Subjects
Engineering, Engineering management, Packaging engineering, business.industry, New product development, Logic testing, Innovation management, Electrical and Electronic Engineering, Marketing, business
Published
2006
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19. Books: The Earth Strikes Back

Author

S. Cass

Subjects
Engineering, business.industry, Publishing, Earth (chemistry), Advertising, Mars Exploration Program, Electrical and Electronic Engineering, business, Telecommunications, Radio broadcasting
Published
2005
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20. Genius on the block: the foundations of the computing age go up for auction

Author

S. Cass

Subjects
Engineering, business.industry, media_common.quotation_subject, Art history, Genius, law.invention, law, Block (telecommunications), Jacquard loom, Karel, Cybernetics, Private collection, Electrical and Electronic Engineering, business, Telecommunications, History of computing, computer, computer.programming_language, media_common
Abstract

In February 2005, the biggest private collection of some of the most important documents in the history of computing and telecommunications went up for sale at Christie's auction house in New York City. These documents include an unpublished 1809 manuscript on the influential Jacquard loom written by Joseph Marie Jacquard himself, a signed first edition of Karel Capek's RUR: Rossum's Universal Robots, the 1920 play that coined the term robot, and Norbert Wiener's own first-edition copy of his 1948 book Cybernetics, heavily annotated by Wiener with corrections for the second edition.

Published
2005
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21. Holiday Gifts

Author

S. Cass

Subjects
Engineering, Automatic control, Multimedia, business.industry, Satellite broadcasting, Loudspeaker, Electrical and Electronic Engineering, business, Telecommunications, computer.software_genre, computer
Published
2005
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24. Fountain of knowledge [analysis engine]

Author

S. Cass

Subjects
World Wide Web, Decision support system, Open platform, Computer science, Web page, Business data processing, Knowledge engineering, Information analysis, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Electrical and Electronic Engineering, Fountain, Data science, Electronic mail
Abstract

This article presents WebFountain, a system that can convert the anarchy of online data - Web pages, e-mail, chat rooms, and more - into a format that can be analyzed to identify commercially valuable information. By leveraging the vast reserves of untapped information online, WebFountain can let companies make smarter business decisions while creating an open platform that encourages more machine understanding research to leave the laboratory.

Published
2004
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25. Saving the station

Author

J. Oberg, A. Zak, and S. Cass

Subjects
Meteorology, Computer science, International Space Station, Station model, Electrical and Electronic Engineering
Published
2003
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27. Listening in [electronic spying]

Author

S. Cass

Subjects
Engineering, Cloud computing security, business.industry, Data security, Espionage, Communications system, Computer security, computer.software_genre, Encryption, Security service, Security through obscurity, Active listening, Electrical and Electronic Engineering, business, Telecommunications, computer
Abstract

The author addresses the following question: are the glory days of electronic spying over-or just beginning? Rather than the creation of ever more sensitive receivers or code-breaking computers, the hot areas of cloak-and-dagger information gathering include tapping fiber-optic cables (even at the bottom of the sea); using tiny bugging devices and old fashioned bribery, blackmail, and burglary to get at data before it has been encrypted; exploiting software flaws and poorly configured communications systems to bypass data security measures; and automatically winnowing the vast amounts of intercepted communications.

Published
2003
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28. Can't we all just get along?

Author

S. Cass

Subjects
End user, business.industry, Computer science, Software as a service, Software development, computer.software_genre, Application software, World Wide Web, Software framework, Component-based software engineering, Software system, Electrical and Electronic Engineering, Web service, business, computer
Abstract

Now the push is on to move beyond simply exchanging data and to allow software applications to employ other applications in the same way that a person might use multiple programs to achieve a task. For example, a person has no problem using a Web browser to download an image, another program to sharpen the image, and finally an e-mail program to send the image to someone else. This effort to expose functionality has ultimately resulted in plans to create so-called Web services These plans originated as companies tried to figure out distributed computing, which spreads heavy computational tasks over multiple computers in a network and yet makes the results appear to the end user as if they were the product of running an application on a single, superpowerful machine.

Published
2003
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29. Multiwavelength observations of Mrk 501 in 2008

Author

MAGIC Collaboration, J. Aleksić(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), S. Ansoldi(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), L. A. Antonelli(INAF National Institute for Astrophysics, I-00136 Rome, Italy), P. Antoranz(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), A. Babic(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), P. Bangale(Max-Planck-Institut für Physik, D-80805 München, Germany), U. Barres de Almeida(Max-Planck-Institut für Physik, D-80805 München, Germany), J. A. Barrio(Universidad Complutense, E-28040 Madrid, Spain), J. Becerra González(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), W. Bednarek(University of Lodz, PL-90236 Lodz, Poland), K. Berger(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), E. Bernardini(Deutsches Elektronen-Synchrotron), A. Biland(ETH Zurich, CH-8093 Zurich, Switzerland), O. Blanch(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), R. K. Bock(Max-Planck-Institut für Physik, D-80805 München, Germany), S. Bonnefoy(Universidad Complutense, E-28040 Madrid, Spain), G. Bonnoli(INAF National Institute for Astrophysics, I-00136 Rome, Italy), F. Borracci(Max-Planck-Institut für Physik, D-80805 München, Germany), T. Bretz(Universität Würzburg, D-97074 Würzburg, Germany), E. Carmona(Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, E-28040 Madrid, Spain), A. Carosi(INAF National Institute for Astrophysics, I-00136 Rome, Italy), D. Carreto Fidalgo(Universität Würzburg, D-97074 Würzburg, Germany), P. Colin(Max-Planck-Institut für Physik, D-80805 München, Germany), E. Colombo(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), J. L. Contreras(Universidad Complutense, E-28040 Madrid, Spain), J. Cortina(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), S. Covino(INAF National Institute for Astrophysics, I-00136 Rome, Italy), P. Da Vela(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), F. Dazzi(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), A. De Angelis(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), G. De Caneva(Deutsches Elektronen-Synchrotron), B. De Lotto(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), C. Delgado Mendez(Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, E-28040 Madrid, Spain), M. Doert(Technische Universität Dortmund, D-44221 Dortmund, Germany), A. Domínguez(Inst. de Astrofísica de Andalucía), D. Dominis Prester(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), D. Dorner(Universität Würzburg, D-97074 Würzburg, Germany), M. Doro(Università di Padova and INFN, I-35131 Padova, Italy), S. Einecke(Technische Universität Dortmund, D-44221 Dortmund, Germany), D. Eisenacher(Universität Würzburg, D-97074 Würzburg, Germany), D. Elsaesser(Universität Würzburg, D-97074 Würzburg, Germany), E. Farina(Università dell'Insubria, Como, I-22100 Como, Italy), D. Ferenc(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), M. V. Fonseca(Universidad Complutense, E-28040 Madrid, Spain), L. Font(Unitat de Física de les Radiacions, Departament de Física, and CERES-IEEC, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain), K. Frantzen(Technische Universität Dortmund, D-44221 Dortmund, Germany), C. Fruck(Max-Planck-Institut für Physik, D-80805 München, Germany), R. J. García López(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), M. Garczarczyk(Deutsches Elektronen-Synchrotron), D. Garrido Terrats(Unitat de Física de les Radiacions, Departament de Física, and CERES-IEEC, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain), M. Gaug(Unitat de Física de les Radiacions, Departament de Física, and CERES-IEEC, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain), G. Giavitto(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), N. Godinović(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), A. González Muñoz(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), S. R. Gozzini(Deutsches Elektronen-Synchrotron), A. Hadamek(Technische Universität Dortmund, D-44221 Dortmund, Germany), D. Hadasch(Institut de Ciències de l'Espai), A. Herrero(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), D. Hildebrand(ETH Zurich, CH-8093 Zurich, Switzerland), J. Hose(Max-Planck-Institut für Physik, D-80805 München, Germany), D. Hrupec(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), W. Idec(University of Lodz, PL-90236 Lodz, Poland), V. Kadenius(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), H. Kellermann(Max-Planck-Institut für Physik, D-80805 München, Germany), M. L. Knoetig(ETH Zurich, CH-8093 Zurich, Switzerland), J. Krause(Max-Planck-Institut für Physik, D-80805 München, Germany), J. Kushida(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), A. La Barbera(INAF National Institute for Astrophysics, I-00136 Rome, Italy), D. Lelas(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), N. Lewandowska(Universität Würzburg, D-97074 Würzburg, Germany), E. Lindfors(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), S. Lombardi(INAF National Institute for Astrophysics, I-00136 Rome, Italy), M. López(Universidad Complutense, E-28040 Madrid, Spain), R. López-Coto(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), A. López-Oramas(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), E. Lorenz(Max-Planck-Institut für Physik, D-80805 München, Germany), I. Lozano(Universidad Complutense, E-28040 Madrid, Spain), M. Makariev(Inst. for Nucl. Research and Nucl. Energy, BG-1784 Sofia, Bulgaria), K. Mallot(Deutsches Elektronen-Synchrotron), G. Maneva(Inst. for Nucl. Research and Nucl. Energy, BG-1784 Sofia, Bulgaria), N. Mankuzhiyil(2,*), K. Mannheim(Universität Würzburg, D-97074 Würzburg, Germany), L. Maraschi(INAF National Institute for Astrophysics, I-00136 Rome, Italy), B. Marcote(Universitat de Barcelona), M. Mariotti(Università di Padova and INFN, I-35131 Padova, Italy), M. Martínez(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), D. Mazin(Max-Planck-Institut für Physik, D-80805 München, Germany), U. Menzel(Max-Planck-Institut für Physik, D-80805 München, Germany), M. Meucci(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), J. M. Miranda(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), R. Mirzoyan(Max-Planck-Institut für Physik, D-80805 München, Germany), A. Moralejo(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), P. Munar-Adrover(Universitat de Barcelona), D. Nakajima(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), A. Niedzwiecki(University of Lodz, PL-90236 Lodz, Poland), K. Nilsson(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), N. Nowak(Max-Planck-Institut für Physik, D-80805 München, Germany), R. Orito(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), A. Overkemping(Technische Universität Dortmund, D-44221 Dortmund, Germany), S. Paiano(Università di Padova and INFN, I-35131 Padova, Italy), M. Palatiello(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), D. Paneque(6,*), R. Paoletti(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), J. M. Paredes(Universitat de Barcelona), X. Paredes-Fortuny(Universitat de Barcelona), S. Partini(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), M. Persic(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), F. Prada(Inst. de Astrofísica de Andalucía), P. G. Prada Moroni(Università di Pisa, and INFN Pisa, I-56126 Pisa, Italy), E. Prandini(Università di Padova and INFN, I-35131 Padova, Italy), S. Preziuso(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), I. Puljak(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), R. Reinthal(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), W. Rhode(Technische Universität Dortmund, D-44221 Dortmund, Germany), M. Ribó(Universitat de Barcelona), J. Rico(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), J. Rodriguez Garcia(Max-Planck-Institut für Physik, D-80805 München, Germany), S. Rügamer(Universität Würzburg, D-97074 Würzburg, Germany), A. Saggion(Università di Padova and INFN, I-35131 Padova, Italy), T. Saito(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), K. Saito(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), M. Salvati(INAF National Institute for Astrophysics, I-00136 Rome, Italy), K. Satalecka(7,*), V. Scalzotto(Università di Padova and INFN, I-35131 Padova, Italy), V. Scapin(Universidad Complutense, E-28040 Madrid, Spain), C. Schultz(Università di Padova and INFN, I-35131 Padova, Italy), T. Schweizer(Max-Planck-Institut für Physik, D-80805 München, Germany), S. N. Shore(Università di Pisa, and INFN Pisa, I-56126 Pisa, Italy), A. Sillanpää(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), J. Sitarek(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), I. Snidaric(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), D. Sobczynska(University of Lodz, PL-90236 Lodz, Poland), F. Spanier(Universität Würzburg, D-97074 Würzburg, Germany), V. Stamatescu(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), A. Stamerra(INAF National Institute for Astrophysics, I-00136 Rome, Italy), T. Steinbring(Universität Würzburg, D-97074 Würzburg, Germany), J. Storz(Universität Würzburg, D-97074 Würzburg, Germany), S. Sun(Max-Planck-Institut für Physik, D-80805 München, Germany), T. Surić(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), L. Takalo(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), F. Tavecchio(INAF National Institute for Astrophysics, I-00136 Rome, Italy), P. Temnikov(Inst. for Nucl. Research and Nucl. Energy, BG-1784 Sofia, Bulgaria), T. Terzić(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), D. Tescaro(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), M. Teshima(Max-Planck-Institut für Physik, D-80805 München, Germany), J. Thaele(Technische Universität Dortmund, D-44221 Dortmund, Germany), O. Tibolla(Universität Würzburg, D-97074 Würzburg, Germany), D. F. Torres(Institut de Ciències de l'Espai), T. Toyama(Max-Planck-Institut für Physik, D-80805 München, Germany), A. Treves(Università dell'Insubria, Como, I-22100 Como, Italy), M. Uellenbeck(Technische Universität Dortmund, D-44221 Dortmund, Germany), P. Vogler(ETH Zurich, CH-8093 Zurich, Switzerland), R. M. Wagner(Max-Planck-Institut für Physik, D-80805 München, Germany), F. Zandanel(Inst. de Astrofísica de Andalucía), R. Zanin(Universitat de Barcelona), VERITAS Collaboration(Deutsches Elektronen-Synchrotron), (Deutsches Elektronen-Synchrotron), B. Behera(Deutsches Elektronen-Synchrotron), M. Beilicke(Department of Physics, Washington University, St. Louis, MO 63130, USA), W. Benbow(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), R. Bird(School of Physics, University College Dublin, Belfield, Dublin 4, Ireland), A. Bouvier(Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064, USA), V. Bugaev(Department of Physics, Washington University, St. Louis, MO 63130, USA), M. Cerruti(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), X. Chen(Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam-Golm, Germany), L. Ciupik(Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605, USA), E. Collins-Hughes(School of Physics, University College Dublin, Belfield, Dublin 4, Ireland), W. Cui(Department of Physics, Purdue University, West Lafayette, IN 47907, USA), C. Duke(Department of Physics, Grinnell College, Grinnell, IA 50112-1690, USA), J. Dumm(School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA), A. Falcone(Department of Astronomy and Astrophysics, 525 Davey Lab, Pennsylvania State University, University Park, PA 16802, USA), S. Federici(now at GRAPPA Institute, University of Amsterdam, 1098XH), Q. Feng(Department of Physics, Purdue University, West Lafayette, IN 47907, USA), J. P. Finley(Department of Physics, Purdue University, West Lafayette, IN 47907, USA), L. Fortson(School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA), A. Furniss(Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064, USA), N. Galante(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), G. H. Gillanders(School of Physics, National University of Ireland Galway, University Road, Galway, Ireland), S. Griffin(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), S. T. Griffiths(Department of Physics and Astronomy, University of Iowa, Van Allen Hall, Iowa City, IA 52242, USA), J. Grube(Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605, USA), G. Gyuk(Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605, USA), D. Hanna(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), J. Holder(Department of Physics and Astronomy and the Bartol Research Institute, University of Delaware, Newark, DE 19716, USA), C. A. Johnson(Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064, USA), P. Kaaret(Department of Physics and Astronomy, University of Iowa, Van Allen Hall, Iowa City, IA 52242, USA), M. Kertzman(Department of Physics and Astronomy, DePauw University, Greencastle, IN 46135-0037, USA), D. Kieda(Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA), H. Krawczynski(Department of Physics, Washington University, St. Louis, MO 63130, USA), M. J. Lang(School of Physics, National University of Ireland Galway, University Road, Galway, Ireland), A. S Madhavan(Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA), G. Maier(Deutsches Elektronen-Synchrotron), P. Majumdar(Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA), K. Meagher(School of Physics and Center for Relativistic Astrophysics, Georgia Institute of Technology, 837 State Street NW, Atlanta, GA 30332-0430), P. Moriarty(Department of Life and Physical Sciences, Galway-Mayo Institute of Technology, Dublin Road, Galway, Ireland), R. Mukherjee(Department of Physics and Astronomy, Barnard College, Columbia University, NY 10027, USA), D. Nieto(Physics Department, Columbia University, New York, NY 10027, USA), A. O'Faoláin de Bhróithe(School of Physics, University College Dublin, Belfield, Dublin 4, Ireland), R. A. Ong(Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA), A. N. Otte(School of Physics and Center for Relativistic Astrophysics, Georgia Institute of Technology, 837 State Street NW, Atlanta, GA 30332-0430), A. Pichel(Instituto de Astronomia y Fisica del Espacio, Casilla de Correo 67 - Sucursal 28), M. Pohl(Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam-Golm, Germany), A. Popkow(Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA), H. Prokoph(Deutsches Elektronen-Synchrotron), J. Quinn(School of Physics, University College Dublin, Belfield, Dublin 4, Ireland), J. Rajotte(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), G. Ratliff(Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605, USA), L. C. Reyes(Physics Department, California Polytechnic State University, San Luis Obispo, CA 94307, USA), P. T. Reynolds(Department of Applied Physics and Instrumentation, Cork Institute of Technology, Bishopstown, Cork, Ireland), G. T. Richards(School of Physics and Center for Relativistic Astrophysics, Georgia Institute of Technology, 837 State Street NW, Atlanta, GA 30332-0430), E. Roache(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), G. H. Sembroski(Department of Physics, Purdue University, West Lafayette, IN 47907, USA), K. Shahinyan(School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA), F. Sheidaei(Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA), A. W. Smith(Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA), D. Staszak(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), I. Telezhinsky(Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam-Golm, Germany), M. Theiling(Department of Physics, Purdue University, West Lafayette, IN 47907, USA), J. Tyler(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), A. Varlotta(Department of Physics, Purdue University, West Lafayette, IN 47907, USA), S. Vincent(Deutsches Elektronen-Synchrotron), S. P. Wakely(Enrico Fermi Institute, University of Chicago, Chicago, IL 60637, USA), T. C. Weekes(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), R. Welsing(Deutsches Elektronen-Synchrotron), D. A. Williams(Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064, USA), A. Zajczyk(Department of Physics, Washington University, St. Louis, MO 63130, USA), B. Zitzer(Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439, USA), External Collaborators(INAF, Osservatorio Astronomico di Torino, I-10025 Pino Torinese), (INAF, Osservatorio Astronomico di Torino, I-10025 Pino Torinese), M. Villata(INAF, Osservatorio Astronomico di Torino, I-10025 Pino Torinese), C. M. Raiteri(INAF, Osservatorio Astronomico di Torino, I-10025 Pino Torinese), M. Ajello(Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720-7450, USA), M. Perri(ASI-Science Data Center, Via del Politecnico, I-00133 Rome, Italy), H. D. Aller(Department of Astronomy, University of Michigan, Ann Arbor, MI 48109-1042, USA), M. F. Aller(Department of Astronomy, University of Michigan, Ann Arbor, MI 48109-1042, USA), V. M. Larionov(Astron. Inst., St.-Petersburg State Univ., Russia), N. V. Efimova(Astron. Inst., St.-Petersburg State Univ., Russia), T. S. Konstantinova(Astron. Inst., St.-Petersburg State Univ., Russia), E. N. Kopatskaya(Astron. Inst., St.-Petersburg State Univ., Russia), W. P. Chen(Graduate Institute of Astronomy, National Central University, 300 Jhongda Rd., Jhongli 32001, Taiwan), E. Koptelova(Graduate Institute of Astronomy, National Central University, 300 Jhongda Rd., Jhongli 32001, Taiwan), H. Y. Hsiao(Graduate Institute of Astronomy, National Central University, 300 Jhongda Rd., Jhongli 32001, Taiwan), O. M. Kurtanidze(Abastumani Observatory, Mt. Kanobili, 0301 Abastumani, Georgia), M. G. Nikolashvili(Abastumani Observatory, Mt. Kanobili, 0301 Abastumani, Georgia), G. N. Kimeridze(Abastumani Observatory, Mt. Kanobili, 0301 Abastumani, Georgia), B. Jordan(School of Cosmic Physics, Dublin Institute For Advanced Studies, Ireland), P. Leto(INAF - Osservatorio Astrofisico di Catania, Italy), C. S. Buemi(INAF - Osservatorio Astrofisico di Catania, Italy), C. Trigilio(INAF - Osservatorio Astrofisico di Catania, Italy), G. Umana(INAF - Osservatorio Astrofisico di Catania, Italy), A. Lahtenmaki(Aalto University Metsähovi Radio Observatory Metsähovintie 114 FIN-02540 Kylmälä Finland), E. Nieppola(Aalto University Metsähovi Radio Observatory Metsähovintie 114 FIN-02540 Kylmälä Finland), M. Tornikoski(Aalto University Metsähovi Radio Observatory Metsähovintie 114 FIN-02540 Kylmälä Finland), J. Sainio(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), M. Giroletti(INAF Istituto di Radioastronomia, 40129 Bologna, Italy), A. Cesarini(University of Trento, Department of Physics, I38050 Povo, Trento, Italy), L. Fuhrmann(Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, 53121 Bonn, Germany), Yu. A. Kovalev(Astro Space Center of the Lebedev Physical Institute, 117997), Y. Y. Kovalev(Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, 53121 Bonn, Germany), Anne Lähteenmäki Group, Department of Radio Science and Engineering, Aalto-yliopisto, Aalto University, Universitat de Barcelona, School services, ELEC, and ~

Subjects
extragalactic background light, Ciencias Físicas, Flux, Electron, Astrophysics, 7. Clean energy, law.invention, purl.org/becyt/ford/1 [https], Raigs gamma, bl lacertae objects, law, individual: Mrk 501 [BL Lacertae objects], Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, 213 Electronic, automation and communications engineering, electronics, Astroparticle physics, BL Lacertae objects: individual: Mrk 501, Gamma rays: general, Astronomy and Astrophysics, Space and Planetary Science, Synchrotron, individual: Mrk 50 [BL Lacertae objects], Homogeneous, astroparticle physics, Spectral energy distribution, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, CIENCIAS NATURALES Y EXACTAS, 1171 Geosciences, Astrophysics::High Energy Astrophysical Phenomena, emitting electrons, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, 114 Physical sciences, bl lacertae objects: individual: mrk 501, crab-nebula, Blazar, Astrophysics::Galaxy Astrophysics, tev blazars, variability, 221 Nanotechnology, Gamma rays, Individual: Mrk 501, Institut für Physik und Astronomie, purl.org/becyt/ford/1.3 [https], gamma rays: general, Galaxies, gamma-ray emission, telescope system, Galàxies, Active Galaxies, blazars, gamma-rays, Mrk 501, Astronomía, Crab Nebula, x-ray, 115 Astronomy and space science, Low emission, 216 Materials engineering, Galàxies actives, active galactic nuclei, Active galaxies, ddc:520, general [gamma rays]
Abstract

Mrk 501 is one of the brightest blazars at TeV energies and has been extensively studied since its first VHE detection in 1996. Our goal is to characterize in detail the source gamma-ray emission, together with the radio-to-X-ray emission, during the non-flaring (low) activity, which is less often studied than the occasional flaring (high) activity. We organized a multiwavelength (MW) campaign on Mrk 501 between March and May 2008. This multi-instrument effort included the most sensitive VHE gamma-ray instruments in the northern hemisphere, namely the imaging atmospheric Cherenkov telescopes MAGIC and VERITAS, as well as Swift, RXTE, the F-GAMMA, GASP-WEBT, and other collaborations and instruments. Mrk 501 was found to be in a low state of activity during the campaign, with a VHE flux in the range of 10%-20% of the Crab nebula flux. Nevertheless, significant flux variations were detected with various instruments, with a trend of increasing variability with energy. The broadband spectral energy distribution during the two different emission states of the campaign can be adequately described within the homogeneous one-zone synchrotron self-Compton model, with the (slightly) higher state described by an increase in the electron number density. This agrees with previous studies of the broadband emission of this source during flaring and non-flaring states. We report for the first time a tentative X-ray-to-VHE correlation during a low VHE activity. Although marginally significant, this positive correlation between X-ray and VHE, which has been reported many times during flaring activity, suggests that the mechanisms that dominate the X-ray/VHE emission during non-flaring-activity are not substantially different from those that are responsible for the emission during flaring activity., Comment: Accepted for publication in A&A

Published
2015
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30. The 2009 multiwavelength campaign on Mrk 421: Variability and correlation studies

Author

MAGIC Collaboration, J. Aleksić(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), S. Ansoldi(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), L. A. Antonelli(INAF National Institute for Astrophysics, I-00136 Rome, Italy), P. Antoranz(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), A. Babic(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), P. Bangale(Max-Planck-Institut für Physik, D-80805 München, Germany), U. Barres de Almeida(Max-Planck-Institut für Physik, D-80805 München, Germany), J. A. Barrio(Universidad Complutense, E-28040 Madrid, Spain), J. Becerra González(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), W. Bednarek(University of Lodz, PL-90236 Lodz, Poland), K. Berger(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), E. Bernardini(Deutsches Elektronen-Synchrotron), A. Biland(ETH Zurich, CH-8093 Zurich, Switzerland), O. Blanch(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), R. K. Bock(Max-Planck-Institut für Physik, D-80805 München, Germany), S. Bonnefoy(Universidad Complutense, E-28040 Madrid, Spain), G. Bonnoli(INAF National Institute for Astrophysics, I-00136 Rome, Italy), F. Borracci(Max-Planck-Institut für Physik, D-80805 München, Germany), T. Bretz(Universität Würzburg, D-97074 Würzburg, Germany), E. Carmona(Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, E-28040 Madrid, Spain), A. Carosi(INAF National Institute for Astrophysics, I-00136 Rome, Italy), D. Carreto Fidalgo(Universität Würzburg, D-97074 Würzburg, Germany), P. Colin(Max-Planck-Institut für Physik, D-80805 München, Germany), E. Colombo(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), J. L. Contreras(Universidad Complutense, E-28040 Madrid, Spain), J. Cortina(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), S. Covino(INAF National Institute for Astrophysics, I-00136 Rome, Italy), P. Da Vela(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), F. Dazzi(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), A. De Angelis(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), G. De Caneva(Deutsches Elektronen-Synchrotron), B. De Lotto(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), C. Delgado Mendez(Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, E-28040 Madrid, Spain), M. Doert(Technische Universität Dortmund, D-44221 Dortmund, Germany), A. Domínguez(Inst. de Astrofísica de Andalucía), D. Dominis Prester(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), D. Dorner(Universität Würzburg, D-97074 Würzburg, Germany), M. Doro(Università di Padova and INFN, I-35131 Padova, Italy), S. Einecke(Technische Universität Dortmund, D-44221 Dortmund, Germany), D. Eisenacher(Universität Würzburg, D-97074 Würzburg, Germany), D. Elsaesser(Universität Würzburg, D-97074 Würzburg, Germany), E. Farina(Università dell'Insubria, Como, I-22100 Como, Italy), D. Ferenc(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), M. V. Fonseca(Universidad Complutense, E-28040 Madrid, Spain), L. Font(Unitat de Física de les Radiacions, Departament de Física, and CERES-IEEC, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain), K. Frantzen(Technische Universität Dortmund, D-44221 Dortmund, Germany), C. Fruck(Max-Planck-Institut für Physik, D-80805 München, Germany), R. J. García López(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), M. Garczarczyk(Deutsches Elektronen-Synchrotron), D. Garrido Terrats(Unitat de Física de les Radiacions, Departament de Física, and CERES-IEEC, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain), M. Gaug(Unitat de Física de les Radiacions, Departament de Física, and CERES-IEEC, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain), G. Giavitto(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), N. Godinović(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), A. González Mu\ noz(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), S. R. Gozzini(Deutsches Elektronen-Synchrotron), A. Hadamek(Technische Universität Dortmund, D-44221 Dortmund, Germany), D. Hadasch(Institut de Ciències de l'Espai), A. Herrero(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), D. Hildebrand(ETH Zurich, CH-8093 Zurich, Switzerland), J. Hose(Max-Planck-Institut für Physik, D-80805 München, Germany), D. Hrupec(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), W. Idec(University of Lodz, PL-90236 Lodz, Poland), V. Kadenius(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), H. Kellermann(Max-Planck-Institut für Physik, D-80805 München, Germany), M. L. Knoetig(ETH Zurich, CH-8093 Zurich, Switzerland), J. Krause(Max-Planck-Institut für Physik, D-80805 München, Germany), J. Kushida(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), A. La Barbera(INAF National Institute for Astrophysics, I-00136 Rome, Italy), D. Lelas(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), N. Lewandowska(Universität Würzburg, D-97074 Würzburg, Germany), E. Lindfors(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), F. Longo(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), S. Lombardi(INAF National Institute for Astrophysics, I-00136 Rome, Italy), M. López(Universidad Complutense, E-28040 Madrid, Spain), R. López-Coto(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), A. López-Oramas(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), E. Lorenz(Max-Planck-Institut für Physik, D-80805 München, Germany), I. Lozano(Universidad Complutense, E-28040 Madrid, Spain), M. Makariev(Inst. for Nucl. Research and Nucl. Energy, BG-1784 Sofia, Bulgaria), K. Mallot(Deutsches Elektronen-Synchrotron), G. Maneva(Inst. for Nucl. Research and Nucl. Energy, BG-1784 Sofia, Bulgaria), N. Mankuzhiyil(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), K. Mannheim(Universität Würzburg, D-97074 Würzburg, Germany), L. Maraschi(INAF National Institute for Astrophysics, I-00136 Rome, Italy), B. Marcote(Universitat de Barcelona), M. Mariotti(Università di Padova and INFN, I-35131 Padova, Italy), M. Martínez(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), D. Mazin(Max-Planck-Institut für Physik, D-80805 München, Germany), U. Menzel(Max-Planck-Institut für Physik, D-80805 München, Germany), M. Meucci(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), J. M. Miranda(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), R. Mirzoyan(Max-Planck-Institut für Physik, D-80805 München, Germany), A. Moralejo(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), P. Munar-Adrover(Universitat de Barcelona), D. Nakajima(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), A. Niedzwiecki(University of Lodz, PL-90236 Lodz, Poland), K. Nilsson(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), N. Nowak(6,32,*), R. Orito(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), A. Overkemping(Technische Universität Dortmund, D-44221 Dortmund, Germany), S. Paiano(Università di Padova and INFN, I-35131 Padova, Italy), M. Palatiello(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), D. Paneque(6,*), R. Paoletti(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), J. M. Paredes(Universitat de Barcelona), X. Paredes-Fortuny(Universitat de Barcelona), S. Partini(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), M. Persic(Università di Udine, and INFN Trieste, I-33100 Udine, Italy), F. Prada(Inst. de Astrofísica de Andalucía), P. G. Prada Moroni(Università di Pisa, and INFN Pisa, I-56126 Pisa, Italy), E. Prandini(Università di Padova and INFN, I-35131 Padova, Italy), S. Preziuso(Università di Siena, and INFN Pisa, I-53100 Siena, Italy), I. Puljak(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), R. Reinthal(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), W. Rhode(Technische Universität Dortmund, D-44221 Dortmund, Germany), M. Ribó(Universitat de Barcelona), J. Rico(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), J. Rodriguez Garcia(Max-Planck-Institut für Physik, D-80805 München, Germany), S. Rügamer(Universität Würzburg, D-97074 Würzburg, Germany), A. Saggion(Università di Padova and INFN, I-35131 Padova, Italy), K. Saito(Japanese MAGIC Consortium, Division of Physics and Astronomy, Kyoto University, Japan), M. Salvati(INAF National Institute for Astrophysics, I-00136 Rome, Italy), K. Satalecka(Universidad Complutense, E-28040 Madrid, Spain), V. Scalzotto(Università di Padova and INFN, I-35131 Padova, Italy), V. Scapin(Universidad Complutense, E-28040 Madrid, Spain), C. Schultz(Università di Padova and INFN, I-35131 Padova, Italy), T. Schweizer(Max-Planck-Institut für Physik, D-80805 München, Germany), S. N. Shore(Università di Pisa, and INFN Pisa, I-56126 Pisa, Italy), A. Sillanpää(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), J. Sitarek(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), I. Snidaric(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), D. Sobczynska(University of Lodz, PL-90236 Lodz, Poland), F. Spanier(Universität Würzburg, D-97074 Würzburg, Germany), V. Stamatescu(IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra, Spain), A. Stamerra(INAF National Institute for Astrophysics, I-00136 Rome, Italy), T. Steinbring(Universität Würzburg, D-97074 Würzburg, Germany), J. Storz(Universität Würzburg, D-97074 Würzburg, Germany), S. Sun(Max-Planck-Institut für Physik, D-80805 München, Germany), T. Surić(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), L. Takalo(Finnish MAGIC Consortium, Tuorla Observatory, University of Turku and Department of Physics, University of Oulu, Finland), F. Tavecchio(INAF National Institute for Astrophysics, I-00136 Rome, Italy), P. Temnikov(Inst. for Nucl. Research and Nucl. Energy, BG-1784 Sofia, Bulgaria), T. Terzić(Croatian MAGIC Consortium, Rudjer Boskovic Institute, University of Rijeka and University of Split, HR-10000 Zagreb, Croatia), D. Tescaro(Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife, Spain), M. Teshima(Max-Planck-Institut für Physik, D-80805 München, Germany), J. Thaele(Technische Universität Dortmund, D-44221 Dortmund, Germany), O. Tibolla(Universität Würzburg, D-97074 Würzburg, Germany), D. F. Torres(Institut de Ciències de l'Espai), T. Toyama(Max-Planck-Institut für Physik, D-80805 München, Germany), A. Treves(Università dell'Insubria, Como, I-22100 Como, Italy), M. Uellenbeck(Technische Universität Dortmund, D-44221 Dortmund, Germany), P. Vogler(ETH Zurich, CH-8093 Zurich, Switzerland), R. M. Wagner(Max-Planck-Institut für Physik, D-80805 München, Germany), F. Zandanel(Inst. de Astrofísica de Andalucía), R. Zanin(Universitat de Barcelona), VERITAS collaboration(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), (Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), S. Archambault(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), B. Behera(Deutsches Elektronen-Synchrotron), M. Beilicke(Department of Physics, Washington University, St. Louis, MO 63130, USA), W. Benbow(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), R. Bird(School of Physics, University College Dublin, Belfield, Dublin 4, Ireland), J. H. Buckley(Department of Physics, Washington University, St. Louis, MO 63130, USA), V. Bugaev(Department of Physics, Washington University, St. Louis, MO 63130, USA), M. Cerruti(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), X. Chen(Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam-Golm, Germany), L. Ciupik(Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605, USA), E. Collins-Hughes(School of Physics, University College Dublin, Belfield, Dublin 4, Ireland), W. Cui(Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA), J. Dumm(School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA), J. D. Eisch(Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA), A. Falcone(Department of Astronomy and Astrophysics, 525 Davey Lab, Pennsylvania State University, University Park, PA 16802, USA), S. Federici(DESY, Platanenallee 6, 15738 Zeuthen, Germany), Q. Feng(Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA), J. P. Finley(Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA), H. Fleischhack(Deutsches Elektronen-Synchrotron), P. Fortin(Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138, USA), L. Fortson(School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA), A. Furniss(Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064, USA), S. Griffin(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), S. T. Griffiths(Department of Physics and Astronomy, University of Iowa, Van Allen Hall, Iowa City, IA 52242, USA), J. Grube(Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605, USA), G. Gyuk(Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605, USA), D. Hanna(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), J. Holder(Department of Physics and Astronomy and the Bartol Research Institute, University of Delaware, Newark, DE 19716, USA), G. Hughes(Deutsches Elektronen-Synchrotron), T. B. Humensky(Physics Department, Columbia University, New York, NY 10027, USA), C. A. Johnson(Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064, USA), P. Kaaret(Department of Physics and Astronomy, University of Iowa, Van Allen Hall, Iowa City, IA 52242, USA), M. Kertzman(Department of Physics and Astronomy, DePauw University, Greencastle, IN 46135-0037, USA), Y. Khassen(School of Physics, University College Dublin, Belfield, Dublin 4, Ireland), D. Kieda(Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA), H. Krawczynski(Department of Physics, Washington University, St. Louis, MO 63130, USA), F. Krennrich(Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA), S. Kumar(Department of Physics and Astronomy and the Bartol Research Institute, University of Delaware, Newark, DE 19716, USA), M. J. Lang(School of Physics, National University of Ireland Galway, University Road, Galway, Ireland), G. Maier(Deutsches Elektronen-Synchrotron), S. McArthur(Enrico Fermi Institute, University of Chicago, Chicago, IL 60637, USA), K. Meagher(School of Physics and Center for Relativistic Astrophysics, Georgia Institute of Technology, 837 State Street NW, Atlanta, GA 30332-0430), P. Moriarty(Department of Life and Physical Sciences, Galway-Mayo Institute of Technology, Dublin Road, Galway, Ireland), R. Mukherjee(Department of Physics and Astronomy, Barnard College, Columbia University, NY 10027, USA), R. A. Ong(Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA), A. N. Otte(School of Physics and Center for Relativistic Astrophysics, Georgia Institute of Technology, 837 State Street NW, Atlanta, GA 30332-0430), N. Park(Enrico Fermi Institute, University of Chicago, Chicago, IL 60637, USA), A. Pichel(Instituto de Astronomia y Fisica del Espacio, Casilla de Correo 67 - Sucursal 28), M. Pohl(Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam-Golm, Germany), A. Popkow(Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA), H. Prokoph(Deutsches Elektronen-Synchrotron), J. Quinn(School of Physics, University College Dublin, Belfield, Dublin 4, Ireland), K. Ragan(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), J. Rajotte(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), P. T. Reynolds(Department of Applied Physics and Instrumentation, Cork Institute of Technology, Bishopstown, Cork, Ireland), G. T. Richards(School of Physics and Center for Relativistic Astrophysics, Georgia Institute of Technology, 837 State Street NW, Atlanta, GA 30332-0430), E. Roache(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), A. C. Rovero(Instituto de Astronomia y Fisica del Espacio, Casilla de Correo 67 - Sucursal 28), G. H. Sembroski(Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA), K. Shahinyan(School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA), D. Staszak(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), I. Telezhinsky(Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam-Golm, Germany), M. Theiling(Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA), J. V. Tucci(Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA), J. Tyler(Physics Department, McGill University, Montreal, QC H3A 2T8, Canada), A. Varlotta(Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA), S. P. Wakely(Enrico Fermi Institute, University of Chicago, Chicago, IL 60637, USA), T. C. Weekes(Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA), A. Weinstein(Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA), R. Welsing(Deutsches Elektronen-Synchrotron), A. Wilhelm(Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam-Golm, Germany), D. A. Williams(Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064, USA), B. Zitzer(Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439, USA), External collaborators(INAF, Osservatorio Astronomico di Torino, I-10025 Pino Torinese), (INAF, Osservatorio Astronomico di Torino, I-10025 Pino Torinese), M. Villata(INAF, Osservatorio Astronomico di Torino, I-10025 Pino Torinese), C. Raiteri(INAF, Osservatorio Astronomico di Torino, I-10025 Pino Torinese), H. D. Aller(Department of Astronomy, University of Michigan, Ann Arbor, MI 48109-1042, USA), M. F. Aller(Department of Astronomy, University of Michigan, Ann Arbor, MI 48109-1042, USA), W. P. Chen(Graduate Institute of Astronomy, National Central University, Jhongli 32054, Taiwan), B. Jordan(School of Cosmic Physics, Dublin Institute for Advanced Studies, Dublin, 2, Ireland), E. Koptelova(Graduate Institute of Astronomy, National Central University, Jhongli 32054, Taiwan), O. M. Kurtanidze(Abastumani Observatory, Mt. Kanobili, 0301 Abastumani, Georgia), A. Lähteenmäki(Aalto University Metsähovi Radio Observatory Metsähovintie 114 FIN-02540 Kylmälä Finland), B. McBreen(University College Dublin, Belfield, Dublin 4, Ireland), V. M. Larionov(Isaac Newton Institute of Chile, St. Petersburg Branch, St. Petersburg, Russia), C. S. Lin(Graduate Institute of Astronomy, National Central University, Jhongli 32054, Taiwan), M. G. Nikolashvili(Abastumani Observatory, Mt. Kanobili, 0301 Abastumani, Georgia), E. Angelakis(Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, 53121 Bonn, Germany), M. Capalbi(ASI-Science Data Center, Via del Politecnico, I-00133 Rome, Italy), A. Carrami\ nana(Instituto Nacional de Astrofísica, Óptica y Electrónica, Tonantzintla, Puebla 72840, Mexico), L. Carrasco(Instituto Nacional de Astrofísica, Óptica y Electrónica, Tonantzintla, Puebla 72840, Mexico), P. Cassaro(INAF Istituto di Radioastronomia, Sezione di Noto, Contrada Renna Bassa, 96017 Noto), A. Cesarini(Department of Physics, University of Trento, I38050, Povo, Trento, Italy), L. Fuhrmann(Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, 53121 Bonn, Germany), M. Giroletti(INAF Istituto di Radioastronomia, 40129 Bologna, Italy), T. Hovatta(Cahill Center for Astronomy and Astrophysics, California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125), T. P. Krichbaum(Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, 53121 Bonn, Germany), H. A. Krimm(Astro Space Center of the Lebedev Physical Institute, 117997 Moscow, Russia), W. Max-Moerbeck(Cahill Center for Astronomy and Astrophysics, California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125), J. W. Moody(Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, USA), G. Maccaferri(INAF Istituto di Radioastronomia, Stazione Radioastronomica di Medicina, I-40059 Medicina), Y. Mori(Department of Physics, Tokyo Institute of Technology, Meguro City, Tokyo 152-8551, Japan), I. Nestoras(Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, 53121 Bonn, Germany), A. Orlati(INAF Istituto di Radioastronomia, Stazione Radioastronomica di Medicina, I-40059 Medicina), C. Pace(Indiana University, Department of Astronomy, Swain Hall West 319, Bloomington, IN 47405-7105, USA), R. Pearson(Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, USA), M. Perri(INAF National Institute for Astrophysics, I-00136 Rome, Italy), A. C. S. Readhead(Cahill Center for Astronomy and Astrophysics, California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125), J. L. Richards(Department of Physics, Purdue University, 525 Northwestern Ave, West Lafayette, IN 47907), A. C. Sadun(Department of Physics, University of Colorado, Denver, CO 80220, USA), T. Sakamoto(Department of Physics and Mathematics, College of Science and 952 Engineering, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuoku, Sagamihara-shi Kanagawa 252-5258, Japan), J. Tammi(Aalto University Metsähovi Radio Observatory Metsähovintie 114 FIN-02540 Kylmälä Finland), M. Tornikoski(Aalto University Metsähovi Radio Observatory Metsähovintie 114 FIN-02540 Kylmälä Finland), Y. Yatsu(Department of Physics, Tokyo Institute of Technology, Meguro City, Tokyo 152-8551, Japan), A. Zook(Department of Physics and Astronomy, Pomona College, Claremont CA 91711-6312, USA), Aleksić, J, Ansoldi, Stefano, Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Carreto Fidalgo, D., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., Delgado Mendez, C., Doert, M., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Farina, E., Ferenc, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., García López, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Giavitto, G., Godinović, N., González Muñoz, A., Gozzini, S. R., Hadamek, A., Hadasch, D., Herrero, A., Hildebrand, D., Hose, J., Hrupec, D., Idec, W., Kadenius, V., Kellermann, H., Knoetig, M. L., Krause, J., Kushida, J., La Barbera, A., Lelas, D., Lewandowska, N., Lindfors, E., Longo, Francesco, Lombardi, S., López, M., López Coto, R., López Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Meucci, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar Adrover, P., Nakajima, D., Niedzwiecki, A., Nilsson, K., Nowak, N., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Partini, S., Persic, M., Prada, F., Prada Moroni, P. G., Prandini, E., Preziuso, S., Puljak, I., Reinthal, R., Rhode, W., Ribó, M., Rico, J., Rodriguezgarcia, J., Rügamer, S., Saggion, A., Saito, K., Salvati, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Stamatescu, V., Stamerra, A., Steinbring, T., Storz, J., Sun, S., Surić, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Uellenbeck, M., Vogler, P., Wagner, R. M., Zandanel, F., Zanin, R., Archambault, S., Behera, B., Beilicke, M., Benbow, W., Bird, R., Buckley, J. H., Bugaev, V., Cerruti, M., Chen, X., Ciupik, L., Collins Hughes, E., Cui, W., Dumm, J., Eisch, J. D., Falcone, A., Federici, S., Feng, Q., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Griffin, S., Griffiths, S. T., Grube, J., Gyuk, G., Hanna, D., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kertzman, M., Khassen, Y., Kieda, D., Krawczynski, H., Krennrich, F., Kumar, S., Lang, M. J., Maier, G., Mcarthur, S., Meagher, K., Moriarty, P., Mukherjee, R., Ong, R. A., Otte, A. N., Park, N., Pichel, A., Pohl, M., Popkow, A., Prokoph, H., Quinn, J., Ragan, K., Rajotte, J., Reynolds, P. T., Richards, G. T., Roache, E., Rovero, A. C., Sembroski, G. H., Shahinyan, K., Staszak, D., Telezhinsky, I., Theiling, M., Tucci, J. V., Tyler, J., Varlotta, A., Wakely, S. P., Weekes, T. C., Weinstein, A., Welsing, R., Wilhelm, A., Williams, D. A., Zitzer, B., Villata, M., Raiteri, C., Aller, H. D., Aller, M. F., Chen, W. P., Jordan, B., Koptelova, E., Kurtanidze, O. M., Lähteenmäki, A., Mcbreen, B., Larionov, V. M., Lin, C. S., Nikolashvili, M. G., Angelakis, E., Capalbi, M., Carramiñana, A., Carrasco, L., Cassaro, P., Cesarini, A., Fuhrmann, L., Giroletti, M., Hovatta, T., Krichbaum, T. P., Krimm, H. A., Max Moerbeck, W., Moody, J. W., Maccaferri, G., Mori, Y., Nestoras, I., Orlati, A., Pace, C., Pearson, R., Perri, M., Readhead, A. C. S., Richards, J. L., Sadun, A. C., Sakamoto, T., Tammi, J., Tornikoski, M., Yatsu, Y., Zook, A., Department of Radio Science and Engineering, Aalto-yliopisto, Aalto University, and Universitat de Barcelona

Subjects
Astrofísica, Brightness, Ciencias Físicas, blazars, Astrophysics, telescope, x-ray variability, 01 natural sciences, Spectral line, BL Lacertae objects, individual, Mrk 421, purl.org/becyt/ford/1 [https], Raigs gamma, emission, MAGIC (telescope), 010303 astronomy & astrophysics, Physics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), individual: Mrk 421 [BL Lacertae objects], Galaxies: BL Lacertae objects: individual: Markarian 421, Spectral energy distribution, Electrónica, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, CIENCIAS NATURALES Y EXACTAS, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Context (language use), Astrophysics::Cosmology and Extragalactic Astrophysics, power spectra, BL Lacertae object, tev photons, 0103 physical sciences, Nucli galàctic actiu, bl lacertae objects: individual: mrk 421, Blazar, Astronomy and Astrophysics, Space and Planetary Science, Active galactic nuclei, 010308 nuclear & particles physics, light curves, Gamma rays, Institut für Physik und Astronomie, purl.org/becyt/ford/1.3 [https], Light curve, Galaxies, Galàxies, Astronomía, Crab Nebula, optical variability, active galactic nuclei, Galàxies actives, Active galaxies, markarian-421, ddc:520
Abstract

We performed a 4.5-month multi-instrument campaign (from radio to VHE gamma rays) on Mrk421 between January 2009 and June 2009, which included VLBA, F-GAMMA, GASP-WEBT, Swift, RXTE, Fermi-LAT, MAGIC, and Whipple, among other instruments and collaborations. Mrk421 was found in its typical (non-flaring) activity state, with a VHE flux of about half that of the Crab Nebula, yet the light curves show significant variability at all wavelengths, the highest variability being in the X-rays. We determined the power spectral densities (PSD) at most wavelengths and found that all PSDs can be described by power-laws without a break, and with indices consistent with pink/red-noise behavior. We observed a harder-when-brighter behavior in the X-ray spectra and measured a positive correlation between VHE and X-ray fluxes with zero time lag. Such characteristics have been reported many times during flaring activity, but here they are reported for the first time in the non-flaring state. We also observed an overall anti-correlation between optical/UV and X-rays extending over the duration of the campaign. The harder-when-brighter behavior in the X-ray spectra and the measured positive X-ray/VHE correlation during the 2009 multi-wavelength campaign suggests that the physical processes dominating the emission during non-flaring states have similarities with those occurring during flaring activity. In particular, this observation supports leptonic scenarios as being responsible for the emission of Mrk421 during non-flaring activity. Such a temporally extended X-ray/VHE correlation is not driven by any single flaring event, and hence is difficult to explain within the standard hadronic scenarios. The highest variability is observed in the X-ray band, which, within the one-zone synchrotron self-Compton scenario, indicates that the electron energy distribution is most variable at the highest energies., Comment: Accepted for publication in A&A, 18 pages, 14 figures (v2 has a small modification in the acknowledgments, and also corrects a typo in the field "author" in the metadata)

Published
2015
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31. Mind games [computer game AI]

Author

S. Cass

Subjects
Game mechanics, Multimedia, Video game development, Computer science, Game programming, ComputingMilieux_PERSONALCOMPUTING, computer.software_genre, GeneralLiterature_MISCELLANEOUS, Turns, rounds and time-keeping systems in games, Emergent gameplay, Electrical and Electronic Engineering, Video game culture, Video game design, Game Developer, computer
Abstract

An increasing number of other games are taking advantage of changes in computer architecture and the growth in processing power to become smarter than ever before. Although most of these games use relatively unsubtle AI techniques, a few pioneers are even showing the academic AI community a trick or two. While AI originated in the laboratory, it has now been coopted by designers of video games, and work is under way on increasing the learning powers of a video games cast of characters and refining their social interactions with one another and with human players, too. At this point, even cinematographers and the military are showing interest in possible applications. To beat the competition, video games are getting smarter. Game AIs have two big advantages over their academic counterparts-they can cheat, and they can get a lot of help from the world they find themselves in.

Published
2002
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32. Improving security, preserving privacy

Author

S. Cass and M.J. Riezenman

Subjects
Truck, Focus (computing), Engineering, Information privacy, business.industry, Internet privacy, Computer security, computer.software_genre, School violence, Terrorism, Doors, Electrical and Electronic Engineering, business, computer
Abstract

Although terrorism is probably the focus of most people's current concern, the need for protection from such nightmares as workplace and school violence has been fanning a demand for more secure environments for some time. Proposed solutions range from the simple, like putting better locks on doors, to the experimental, like automatic face-recognition systems. On a long-term basis, they even include architectural measures: designing buildings so that bomb-laden trucks cannot readily approach them. The privacy aspects of such surveillance are discussed in this article.

Published
2002
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33. The relevance of the interpersonal theory of suicide for predicting past-year and lifetime suicidality in autistic adults

Author

R. L. Moseley, N. J. Gregory, P. Smith, C. Allison, S. Cassidy, and S. Baron-Cohen

Subjects
Suicide, Thwarted belongingness, Perceived burdensomeness, Acquired capability, Relationships, Age at diagnosis, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background While there are known risk factors for suicidality in autistic adults, these are often unconnected from theoretical frameworks that might explain why risk is elevated and guide clinical interventions. The present study investigated the relevance of constructs from the Interpersonal Theory of Suicide (ITS), including perceived burdensomeness, thwarted belongingness and acquired capability for suicide, and explored mechanisms through which certain risk factors (relationship status, age at diagnosis) might elevate suicide risk. Methods Autistic adults (n = 314) completed an online study including measures of depression, anxiety and constructs from the ITS. Linear and multinomial regression analysis disentangled contributions of ITS variables from effects of depression and anxiety for past-year suicide ideation, past-year and lifetime suicide attempts. Mediation analyses examined associations between risk factors and these suicide outcomes via mechanisms proposed by the ITS. Results Past-year suicide ideation was associated with burdensomeness, mental rehearsal of suicide plans (a facet of acquired capability), and depression. Greater feelings of burdensomeness, and reduced fear of death, marked out participants who had attempted suicide in comparison to those who had experienced suicide ideation in the past year. Relationship status was indirectly associated with past-year suicide ideation via the mediators of depression and burdensomeness, and was associated with past-year attempts via its effect on ideation. Age at diagnosis was unrelated to any variables. Limitations Cross-sectional research is insensitive to causality and temporal dynamics, which is likely why interaction hypotheses from the ITS were unsupported. Normative measures may be invalid in autistic samples. There was no control group. The autistic sample was unrepresentative of the whole population, particularly autistic people with intellectual disabilities, ethnic/racial minorities, and gender minorities. Conclusions Perceived burdensomeness and acquired capability appear potentially important to suicide in autistic people, and may mediate the effects of some risk factors. Future research should explore the temporal dynamics of suicide trajectories in longitudinal, prospective designs.

Published
2022
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34. 708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects:analysis for association with psychiatric disorder and cognitive traits

Author

Douglas Blackwood, Melissa Kramer, Shane McCarthy, S. W. Morris, Ian J. Deary, David J. Porteous, Jianchao Yao, Jennifer Parla, James D. Watson, S Cass, Dinesh C. Soares, J. K. Millar, Andrew M. McIntosh, D Rebolini, W. R. McCombie, John M. Starr, Kathryn L. Evans, Peter M. Visscher, Donald J. MacIntyre, Sarah E. Harris, L Cardone, Pippa A. Thomson, Elena Ghiban, Allan F. McRae, William Hennah, and K Ramakrishnan

Subjects
Candidate gene, medicine.medical_specialty, Bipolar Disorder, DNA Mutational Analysis, Nerve Tissue Proteins, Single-nucleotide polymorphism, Biology, Bioinformatics, Polymorphism, Single Nucleotide, White People, DISC1, recurrent major depressive disorder, sequencing, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cognition, 0302 clinical medicine, Gene Frequency, medicine, Humans, Family, Genetic Predisposition to Disease, Bipolar disorder, 1000 Genomes Project, Psychiatry, DISC1, Molecular Biology, Allele frequency, Exome sequencing, 030304 developmental biology, Genetic association, Genetics, Depressive Disorder, Major, 0303 health sciences, recurrent major depressive disorder, Mental Disorders, Exons, sequencing, medicine.disease, Pedigree, Minor allele frequency, Psychiatry and Mental health, Scotland, Schizophrenia, Original Article, 030217 neurology & neurosurgery
Abstract

A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and recurrent major depressive disorder (rMDD) in a single large Scottish family, but genome-wide and exome sequencing-based association studies have not supported a role for DISC1 in psychiatric illness. To explore DISC1 in more detail, we sequenced 528 kb of the DISC1 locus in 653 cases and 889 controls. We report 2718 validated single-nucleotide polymorphisms (SNPs) of which 2010 have a minor allele frequency of

Published
2014
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35. Anatomy of malice [computer viruses]

Author

S. Cass

Subjects
Focus (computing), Software_OPERATINGSYSTEMS, Computer science, viruses, media_common.quotation_subject, Military computing, Computer security, computer.software_genre, Malice, Computer virus, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, Computer worm, Key (cryptography), Malware, Electrical and Electronic Engineering, computer, media_common
Abstract

As in controlling the spread of real diseases, the key to effective defenses against computer viruses is to understand the cause and mechanism of infection, not to focus on the symptoms. A computer virus that erases a user's files may seem very different from one that merely prints out the occasional annoying message, but chances are, they both got into the system in a similar fashion. Malicious software falls, by and large, into three classes: Trojans, viruses, and worms. The way in which these viruses work is explained, as are methods to counteract them.

Published
2001
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36. MEMS in space

Author

S. Cass

Subjects
Microelectromechanical systems, Engineering, Spacecraft, business.industry, Microfluidics, Electrical engineering, Satellite, Electronics, Electrical and Electronic Engineering, Space (commercial competition), business, Aerospace, Accelerometer
Abstract

The satellite industry could experience its biggest revolution since it joined the ranks of commerce, thanks to some of the smallest machines in existence. Researchers are performing experiments designed to convince the aerospace industry that microelectromechanical systems (MEMS) could open the door to low-cost, high-reliability, mass-produced satellites. MEMS combine conventional semiconductor electronics with beams, gears, levers, switches, accelerometers, diaphragms, microfluidic thrusters, and heat controllers, all of them microscopic in size. Some of the advantages of using MEMS-based satellites are low launch costs and high resistance to radiation and vibration. MEMS-based satellites also promise to be cheaper to develop and fabricate than conventional spacecraft.

Published
2001
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37. 2001: a Mars Odyssey

Author

S. Cass

Subjects
Physics, Infrared astronomy, Spacecraft, Gamma ray spectrometer, business.industry, Astronomy, Gamma-ray astronomy, Mars Exploration Program, Mars odyssey, Astrobiology, Mars Radiation Environment Experiment, Thermal Emission Imaging System, Electrical and Electronic Engineering, business
Abstract

Discusses the mission of the Mars Odyssey spacecraft launched in April 2001. Brief mention is made of the Thermal Emission Imaging System (Themis), Gamma Ray Spectrometer, and the Mars Radiation Environment Experiment (Marie).

Published
2001
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38. Electronic realism [art and technology]

Author

S. Cass

Subjects
Multimedia, Computer science, Digital art, ComputingMilieux_COMPUTERSANDEDUCATION, Electrical and Electronic Engineering, computer.software_genre, computer, Art and technology, Computer animation, Realism
Abstract

In this paper, the author describes how a cadre of students and educators is using the latest digital techniques to animate art and humanize technology.

Published
2001
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39. Project: HIV Prevention for Incarcerated Youth in Indiana

Author

Nancy Schlapman and Penny S. Cass

Subjects
Male, Gerontology, Program evaluation, Health Knowledge, Attitudes, Practice, Indiana, Adolescent, Sexual Behavior, Human immunodeficiency virus (HIV), HIV Infections, Sex Education, medicine.disease_cause, Peer Group, Risk-Taking, Acquired immunodeficiency syndrome (AIDS), Risk Factors, Surveys and Questionnaires, Pandemic, medicine, Juvenile delinquency, Humans, Community and Home Care, North central, Prisoners, Public Health, Environmental and Occupational Health, Peer group, medicine.disease, Adolescent population, Juvenile Delinquency, Educational Status, Female, Psychology, Program Evaluation
Abstract

Both Indiana and national statistics suggest that HIV-AIDS cases continue to rise in the adolescent population. Because of environmental factors, incarcerated adolescents may be at a greater risk of exposure to HIV-AIDS. Educational programs, such as the one funded for this project, may be an important step in impacting the current pandemic nature of HIV-AIDS. An educational project consisting of 4 peer-based, interactive sessions was developed for incarcerated adolescents in a north central Indiana juvenile center. The project sessions were developed from the National Network of Runaway and Youth Services (1994). Project objectives were based on the AIDS Risk Reduction Model (ARRM) and were measured by a 40-item tool developed from the ARRM. Project objectives were as follows: Detainees would (a) participate in 4 educational sessions related to high-risk sexual behavior, (b) recognize and label their own sexual behaviors that put them at risk for contracting AIDS, and (c) make a commitment to reduce high-risk sexual behaviors. During the first year of state funding, 91 educational sessions were conducted, reaching a total of 196 detainees. Following comparisons of the preproject and postproject questionnaires, detainees demonstrated an increase in their ability to appropriately recognize and label risky behaviors, but they evidenced no significant commitment to change their behaviors.

Published
2000
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40. Radiation Awareness Program for Extracorporeal Shockwave Lithotripsy Using Medstone Lithotripters

Author

Roland Ugarte and Alexander S. Cass

Subjects
medicine.medical_specialty, Ureteral Calculi, business.industry, Urology, medicine.medical_treatment, Urinary stone, Stone size, Awareness, Lithotripsy, Radiation Dosage, RADIOLOGIC TECHNOLOGIST, Extracorporeal, Surgery, Radiation exposure, Kidney Calculi, Extracorporeal shockwave lithotripsy, Treatment Outcome, Retreatment, Humans, Medicine, X ray irradiation, Radiology, business, Program Evaluation
Abstract

To determine the effectiveness of a radiation awareness program in reducing the radiation exposure to patients treated by a Medstone lithotripter, the exposure was calculated at the end of each extracorporeal shockwave (SWL) treatment using a table of measurements of the estimated entrance exposure rates 70 cm from the X-ray tube port. The results, related to stone size and patient weight, were distributed every month to each radiologic technologist, and a summary was sent regularly to the treating urologists. The doses before and after the introduction of the radiation awareness program were compared to determine the effectiveness of the program, and the chi-square test was used to determine statistical significance. The average calculated radiation exposure before and after introduction of the radiation awareness program was 16.39 rad and 8.26 rad, respectively, for patients with single renal stones; 17.31 rad and 9.02 rad, respectively, with single ureteral stones; 18.45 rad and 9.39 rad, respectively, with multiple renal stones; and 20.59 rad and 11.28 rad, respectively with multiple ureteral stones. These reductions in calculated radiation exposure were statistically significant only with multiple ureteral stones (P = 0.03). The only statistically significant differences in the stone-free rates, retreatment rates, and post-SWL secondary procedure rates before and after the introduction of the radiation awareness program were seen in the stone-free rates with single renal stones: 70% v 65%, respectively (P = 0.02); in the retreatment rates with single ureteral stones: 10% v 6%, respectively ( P.01); and in the post-SWL secondary procedure rates with single renal stones: 4% v 2%, respectively (P = 0.01), and single ureteral stones: 7% v 4%, respectively (P = 0.05). The radiation awareness program resulted in a 51% reduction in the estimated radiation exposure to patients during SWL using Medstone lithotripters.

Published
1998
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41. Books: Money For Nothing Reviewed

Author

S. Cass

Subjects
Engineering, Software bug, business.industry, Nothing, Forensic engineering, Engineering ethics, Electrical and Electronic Engineering, business
Published
2006
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42. A method out of madness [professional profile]

Author

S. Cass

Subjects
Engineering management, Engineering, Software, business.industry, Electrical and Electronic Engineering, business, Productivity, ComputingMilieux_MISCELLANEOUS, Management
Abstract

This paper presents an interview with David Allen, author of the self-help book entitled "Getting Things Done: The Art of Stress-Free Productivity". In the interview, Allen discusses his ideas on how people can be more organized and become more productive with the aid of various software and high-tech gadgets.

Published
2006
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43. Prolonged laparoscopic surgery is associated with an increased risk of vertebral disc prolapse

Author

V. Akande, G. K. S. Cass, and S. Vyas

Subjects
Laparoscopic surgery, medicine.medical_specialty, business.industry, medicine.medical_treatment, Obstetrics and Gynecology, Human factors and ergonomics, DISC PROLAPSE, Gynaecological endoscopy, United Kingdom, Surgery, Increased risk, Occupational Exposure, Medicine, Humans, Personal health, Laparoscopy, Ergonomics, business, Intervertebral Disc Displacement
Abstract

The benefits of laparoscopic surgery to the patient are well recognised, however it is more physically demanding on the surgeon. A survey was sent to members of the British Society of Gynaecological Endoscopy to ascertain musculoskeletal symptoms and vertebral disc prolapse thought to occur as a result of undertaking laparoscopic surgery. A total of 19 (15%) participants were diagnosed with a vertebral disc prolapse, for which one-third needed definitive treatment. There was a statistically significant association with length of practice and numbers of hours worked per week, with the risk of disc prolapse. There was a multitude of other musculoskeletal symptoms reported. These findings suggest that gynaecological laparoscopic surgery carries a high personal health risk to the surgeon, which is likely to increase as the capability and superiority of laparoscopic techniques develop. There is an urgent need to explore further the ergonomic impact of laparoscopic work to enable improvements to be made.

Published
2013

44. Tools & Toys : IPOD a Go-Go

Author

S. Cass

Subjects
Engineering, Boosting (machine learning), Multimedia, Product design, Acoustical engineering, business.industry, Engineering profession, Electrical and Electronic Engineering, computer.software_genre, business, computer
Published
2004
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45. Book review: Small Things Considered

Author

S. Cass

Subjects
Engineering management, Engineering, Emergency management, business.industry, Engineering ethics, Telephony, Electrical and Electronic Engineering, business, Aerospace
Published
2004
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46. Finding the needle in the haystack [search engines]

Author

S. Cass

Subjects
Computer science, business.industry, Internet privacy, Computer security, computer.software_genre, Entertainment, Search engine, Software, Channel (programming), Peer to peer computing, Pornography, Electrical and Electronic Engineering, Haystack, business, computer
Abstract

A new search technology could make peer-to-peer networks easier to use and help them become a legitimate online distribution channel. The decentralized designs common to public peer-to-peer networks make them resistant to legal or technological disruption, but they also create a weakness: it's hard to find anything but the most popular material, usually illegal music or barely legal pornography. Now, Los Angeles-based Streamcast Networks Inc. hopes to fix that weakness and to improve peer-to-peer's image into the bargain with a new search technology known as NEOnet. NEOnet is integrated into Streamcast's signature peer-to-peer software, Morpheus. NEOnet is so important to Streamcast's strategy. It seeks, through NEOnet's improved ability, to find files other than musing or the pinup du jour, to get users to accept Streamcast's peer-to-peer network as a reliable place to find legitimate information, entertainment or software, much as the Web is used today. But NEOnet also offers the advantage that a peer-to-peer network can help share the load currently associated with hosting such content on the Web.

Published
2004
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47. Books: Half-Speed Ahead

Author

S. Cass

Subjects
Engineering, medicine.anatomical_structure, business.industry, medicine, Electrical engineering, Auditory system, Human multitasking, Electrical and Electronic Engineering, business
Published
2004
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48. Comparison of First Generation (Dornier HM3) and Second Generation (Medstone STS) Lithotriptors: Treatment Results With 13,864 Renal and Ureteral Calculi

Author

Alexander S. Cass

Subjects
medicine.medical_specialty, Ureteral Calculi, Urology, medicine.medical_treatment, Lithotripsy, Treatment results, urologic and male genital diseases, Kidney Calculi, Extracorporeal shockwave lithotripsy, Ureter, medicine, Humans, Chi-Square Distribution, business.industry, Equipment Design, Treatment rate, Secondary procedure, Extracorporeal shock wave lithotripsy, female genital diseases and pregnancy complications, First generation, Surgery, medicine.anatomical_structure, business, Follow-Up Studies
Abstract

Some reports have shown a decreased effectiveness of extracorporeal shock wave lithotripsy (ESWL*) with newer lithotriptors. We used a first generation unmodified Dornier HM3 lithotriptor to treat 5,698 patients with renal and ureteral calculi and a second generation Medstone STS device to treat 8,166 patients with renal and ureteral calculi. The treatment results were compared using the chi-square test to determine statistical significance. The stone-free rate, retreatment rate and post-ESWL secondary procedure rate were 69.5%, 4.4% and 3.1%, respectively, with the Dornier HM3 device and 72.1%, 4.9% and 2.3%, respectively, with the Medstone lithotriptor for single renal stones, and 81.5%, 5.2% and 5.5%, respectively, with the Dornier HM3 and 83.2%, 5.2% and 5.0%, respectively, with the Medstone device for single ureteral stones. There were no statistically significant different results between a second generation tubless Medstone STS lithotriptor and the gold standard unmodified Dornier HM3 instrument. Kcr WORDS: kidney calculi, ureteral calculi, extracorporeal shockwave lithotripsy, lithotripsy There have been reports that the newer lithotriptors have a decreased effectiveness compared to the original gold standard Dornier HM3 The second generation lithotriptors have a dry table with easier patient handling and are less powerful with minimized anesthesia requirements. However, decreased effectiveness results in an increased number of shocks given, decreased stone-free rate and increased repeat extracorporeal shock wave lithotripsy (ESWLJ treatment rate. We reviewed the treatment results of an unmodified Dornier HM3 device with 5,698 renal and ureteral calculi, and of the Medstone STS lithotriptor with 8,166 renal and ureteral calculi. We used the chi-square test to determine any statistical significance for any difference in these results.

Published
1995
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