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Piscine orthoreovirus (PRV-1) is a segmented RNA virus, which is commonly found in salmonids in the Atlantic and Pacific Oceans. PRV-1 causes the heart and skeletal muscle inflammation disease in Atlantic salmon and is associated with several other disease conditions. Previous phylogenetic studies of genome segment 1 (S1) identified four main genogroups of PRV-1 (S1 genogroups I–IV). The goal of the present study was to use Bayesian phylogenetic inference to expand our understanding of the spatial, temporal, and host patterns of PRV-1 from the waters of the northeast Pacific. To that end, we determined the coding genome sequences of fourteen PRV-1 samples that were selected to improve our knowledge of genetic diversity across a broader temporal, geographic, and host range, including the first reported genome sequences from the northwest Atlantic (Eastern Canada). Nucleotide and amino acid sequences of the concatenated genomes and their individual segments revealed that established sequences from the northeast Pacific were monophyletic in all analyses. Bayesian inference phylogenetic trees of S1 sequences using BEAST and MrBayes also found that sequences from the northeast Pacific grouped separately from sequences from other areas. One PRV-1 sample (WCAN_BC17_AS_2017) from an escaped Atlantic salmon, collected in British Columbia but derived from Icelandic broodstock, grouped with other S1 sequences from Iceland. Our concatenated genome and S1 analysis demonstrated that PRV-1 from the northeast Pacific is genetically distinct but descended from PRV-1 from the North Atlantic. However, the analyses were inconclusive as to the timing and exact source of introduction into the northeast Pacific, either from eastern North America or from European waters of the North Atlantic. There was no evidence that PRV-1 was evolving differently between free-ranging Pacific Salmon and farmed Atlantic Salmon. The northeast Pacific PRV-1 sequences fall within genogroup II based on the classification of Garseth, Ekrem, and Biering (Garseth, A. H., Ekrem, T., and Biering, E. (2013) ‘Phylogenetic Evidence of Long Distance Dispersal and Transmission of Piscine Reovirus (PRV) between Farmed and Wild Atlantic Salmon’, PLoS One, 8: e82202.), which also includes North Atlantic sequences from Eastern Canada, Iceland, and Norway. The additional full-genome sequences herein strengthen our understanding of phylogeographical patterns related to the northeast Pacific, but a more balanced representation of full PRV-1 genomes from across its range, as well additional sequencing of archived samples, is still needed to better understand global relationships including potential transmission links among regions.

Capsules in National Ignition Facility targets are conventionally supported by thin polymer films. Recent experiments have shown that these films add significant perturbations to the implosion. Here, we evaluate stiffer polyimide composite films for use in a new target design that has been predicted to reduce these perturbations. The films are evaluated by their contact radius to the capsule for different deflections and the force they generate at those deflections to center the capsule. We find that a composite film with a single-sided coating of carbon produces the best results and show the performance of these films in target assemblies, highlighting the importance of the indentation depth.

Factors influencing the health of sockeye salmon Oncorhynchus nerka in British Columbia, Canada, are important for fisheries management and conservation. Juvenile salmon originating from the Fraser River were screened for 3 enzootic parasites (Myxobolus arcticus, Parvicapsula minibicornis, Ceratonova shasta) and the bacterium Renibacterium salmoninarum. Fish were collected from the Strait of Georgia in 2010, 2011 and 2012 and genotyped to stock of origin. Trends in infection status were estimated by year, spawning zone and catch area. The annual prevalences of P. minibicornis (n = 1448) were 23.3, 6.5 and 8.1%, and for M. arcticus (n = 1343), annual prevalences were 40.4, 66.3 and 27.4%, respectively. Logistic regression showed that P. minibicornis was most strongly associated with salmon from the lower Fraser River spawning zone and increased with distance caught from the mouth of the Fraser River. In contrast, infection with M. arcticus was most strongly associated with salmon from the middle Fraser River spawning zone, and there was no trend related to distance from the Fraser River. Neither R. salmoninarum nor C. shasta were detected. These observations are discussed in the context of salmon life history and pathogen biology.

This paper presents an exploration of potential mitigation methods for the gas fuel fill tube in Inertial Confinement Fusion (ICF) implosions at the National Ignition Facility (NIF), and the impact of hydrodynamic growth seeded from other target imperfections using a specialized low convergence implosion experiment. Enhanced x-ray self- emission of this experiment design allows the impact of hydrodynamic growth through the deceleration phase of the implosion to be examined. Experiments are presented comparing the perturbation visible during the implosion deceleration that are seeded by the fill tube, through varying the initial geometry in otherwise similar implosions. We further extend the experiment to explore the impact of isolated high atomic number 'dots' of 5 and 20 µm diameter. These isolated dots are compared in two different ‘High Density Carbon’ ablator designs in a gold hohlraum. The experiment series finds a correlation to number of high frequency self-emission features observed in deceleration and degradation in total Deuterium-Deuterium neutron yield.

Experiments on imploding an Al capsule in a Au rugby hohlraum with up to a 1.5 MJ laser drive were performed on the National Ignition Facility (NIF). The capsule diameter was 3.0 mm with ∼1 MJ drive and 3.4 mm with ∼1.5 MJ drive. Effective symmetry tuning by modifying the rugby hohlraum shape was demonstrated, and good shell symmetry was achieved for 3.4 mm capsules at a convergence of ∼10. The nuclear bang time and the shell velocity from simulations agree with experimental data, indicating ∼500 kJ coupling with 1.5 MJ drive or ∼30% efficiency. The peak velocity reached above 300 km/s for a 120 μm-thick Al capsule. The laser backscatter inside the low-gas-filled rugby hohlraum was very low (

Peer assessment (PA) is a commonly applied evaluation strategy in the educational context not only due to its effectiveness to reduce instructor’s evaluation loading, but also its benefit towards student development such as teamwork, reading and judgment skills. Previously, there are a number of related studies that have explored multiple issues of PA and how these factors affect the PA quality. Nevertheless, the effect of content knowledge mastery and evaluation experience towards PA quality is less emphasized. In this study, the author wish to quantitatively examine how content knowledge mastery and experience of evaluators can affect the evaluation outcome. For this purpose, a case study involving 29 student evaluators was performed, where evaluators were required to rate two written assignments of a production engineering course project. The findings of this study is detailed in the case study section. The author then conclude the findings with further discussion and future works.

Bibliometric analysis is a useful approach to identify key authors, research themes, and evolution of a research field. Previously, there exist a number of related studies on field development of engineering education and design engineering using various analytical approaches. Nevertheless, bibliometric analysis of the design engineering education (DEE) field, an emerging cross-disciplinary research sub-field under the field of engineering education, is still absent. In this study, we suggest a methodology to analyze the research themes and its evolution in the DEE field. A case study that illustrate our methodology is performed using DEE's bibliometric data downloaded from the SCOPUS database. Upon data pre-processing steps, research evolution of the DEE field is presented visually using strategic mapping and thematic evolution network over the years 2010–2015 with discovered insights discussed. We summarize our findings with some discussion on future works.

Building environment plays an important role in ensuring a healthy and productive environment for indoor occupants. However, with the increasing demand for comfortable thermal environment and the call for sustainable building operation, achieving a balance between energy consumption and user's thermal preference is challenging. From the informatics perspective, previous studies mainly focused on intelligent building system and occupants activity analysis, while the research on knowledge discovery from building information for optimized building operation is less emphasized. In this paper, we propose a framework for information processing and knowledge discovery for sustainable building environment. Using ubiquitous wireless sensor networks, we showcase how we can feasibly collect and analyze sensory data for the benefit of building environmental assessment and building system control. A case study involving indoor environmental monitoring at two university offices is presented to showcase our approach. We then conclude our work with some discussion on future works.

The sexual process of C. moewusii from gametic activation through germination of the zygote has been studied with phase-contrast and electron microscopy. Long strands emerging from the gametic flagellar tips are the site of early flagellar attraction which is followed by union of compatible flagella within common flagellar sheaths. The gametic connecting strand is formed by coordinated elongation of the plasma papillae of a gametic pair and the penetration of the former through their wall papillae while the flagella are in intimate association. After the free-swimming period, the gametic pairs aggregate in a second period of clumping. The connecting strand is abscised and extruded during plas-mogamy as are the flagellar basal bodies. Evidence is presented which suggests union of the gametic plastids, and stages in karyogamy are illustrated. Formation of the wall layers, accumulation of starch and lipids, and changes in plastid organization in the maturing and germinating zygote are described as is the formation of the gonal walls.

Introduction.Cesarean scar pregnancies (CSPs) are one of the rarest forms of ectopic pregnancy. Given their rarity, there is lack of consensus regarding the management and natural course of CSPs.Case.A 37-year-old G10 P3063 female with a history of two prior cesarean deliveries was diagnosed with her second CSP at 6 weeks and 5 days in her tenth pregnancy. The patient underwent vertical hysterotomy, excision of a gestational sac implanted in the cesarean sac, and bilateral salpingectomy via a laparotomy incision. The histopathology report confirmed immature chorionic villi. The patient returned 10 weeks later and was found to be still pregnant. Obstetric ultrasound confirmed a viable fetus of 19 weeks and 4 days of gestational age with a thin endometrium and an anteroposterior and right lateral placenta with multiple placental lakes. The patient ruptured her membranes at 31 weeks of gestation and pelvic MRI revealed an anterior placenta invading the myometrium and extending to the external serosal surface consistent with placenta increta. Following obstetric interventions, a live female infant was delivered by cesarean hysterectomy (because of placenta increta) at 32 weeks of gestation.Conclusion.Development of standardized guidelines for management of CSPs, as well as heightened vigilance for possible complications, is required for proper care and avoidance of potential morbidity and mortality.

Achieving a symmetric implosion in National Ignition Facility indirect drive targets requires understanding and control of dynamic changes to the laser power transport in the hohlraum. We developed a new experimental platform to simultaneously visualize wall-plasma motion and dynamic laser power transport in the hohlraum and are using it to investigate correlations of these measurements with the imploded capsule symmetry. In a series of experiments where we made one single parameter variation, we show the value of this new platform in developing an understanding of laser transport and implosion symmetry. This platform also provides a new way to evaluate dynamic performance of advanced hohlraum designs.

Hydrodynamic instabilities and asymmetries are a major obstacle in the quest to achieve ignition at the National Ignition Facility (NIF) as they cause pre-existing capsule perturbations to grow and ultimately quench the fusion burn in experiments. This paper reviews the development of two new experimental techniques to measure high-mode instabilities and low-mode asymmetries in the deceleration phase of indirect drive inertial confinement fusion implosions. In the first innovative technique, self-emission from the hot spot was enhanced with an argon dopant to “self-backlight” the shell in-flight, imaging the perturbations in the shell near peak velocity. Experiments with pre-imposed two-dimensional perturbations showed hydrodynamic instability growth of up to 7000× in areal density. These experiments discovered unexpected three-dimensional structures originating from the capsule support structures. These new 3-D structures became one of the primary concerns for the indirect drive ICF program that requires their origin to be understood and their impact mitigated. In a second complementary technique, the inner surface of the decelerating shell was visualized in implosions using x-ray emission of a high-Z dopant added to the inner surface of the capsule. With this technique, low mode asymmetry and high mode perturbations, including perturbations seeded by the gas fill tube and capsule support structure, were quantified near peak compression. Using this doping method, the role of perturbations and radiative losses from high atomic number materials on neutron yield was quantified.Hydrodynamic instabilities and asymmetries are a major obstacle in the quest to achieve ignition at the National Ignition Facility (NIF) as they cause pre-existing capsule perturbations to grow and ultimately quench the fusion burn in experiments. This paper reviews the development of two new experimental techniques to measure high-mode instabilities and low-mode asymmetries in the deceleration phase of indirect drive inertial confinement fusion implosions. In the first innovative technique, self-emission from the hot spot was enhanced with an argon dopant to “self-backlight” the shell in-flight, imaging the perturbations in the shell near peak velocity. Experiments with pre-imposed two-dimensional perturbations showed hydrodynamic instability growth of up to 7000× in areal density. These experiments discovered unexpected three-dimensional structures originating from the capsule support structures. These new 3-D structures became one of the primary concerns for the indirect drive ICF program that requires...

Hydrodynamic instability growth of capsule support membranes (or “tents”) has been recognized as one of the major contributors to the performance degradation in high-compression plastic capsule implosions at the National Ignition Facility (NIF) [E. M. Campbell et al., AIP Conf. Proc. 429, 3 (1998)]. The capsules were supported by tents because the nominal 10-μm diameter fill tubes were not strong enough to support capsules by themselves in indirect-drive implosions on NIF. After it was recognized that the tents had a significant impact of implosion's stability, new alternative support methods were investigated. While some of these methods completely eliminated tent, other concepts still used tents, but concentrated on mitigating their impact. The tent-less methods included “fishing pole” reinforced fill tubes, cantilevered fill tubes, and thin-wire “tetra cage” supports. In the “fishing pole” concept, a 10-μm fill tube was inserted inside 30-μm fill tube for extra support with the connection point located 300 μm away from the capsule surface. The cantilevered fill tubes were supported by 12-μm thick SiC rods, offset by up to 300 μm from the capsule surfaces. In the “tetra-cage” concept, 2.5-μm thick wires (carbon nanotube yarns) were used to support a capsule. Other concepts used “polar tents” and a “foam-shell” to mitigate the effects of the tents. The “polar tents” had significantly reduced contact area between the tents and the capsule compared to the nominal tents. In the “foam-shell” concept, a 200-μm thick, 30 mg/cc SiO2 foam layer was used to offset the tents away from the capsule surface in an attempt to mitigate their effects. These concepts were investigated in x-ray radiography experiments and compared with perturbations from standard tent support. The measured perturbations in the “fishing pole,” cantilevered fill tube, and “tetra-cage” concepts compared favorably with (were smaller than) nominal tent perturbations and were recommended for further testing for feasibility in layered DT implosions. The “polar tents” were tested in layered DT implosions with a relatively-stable “high-foot” drive showing an improvement in neutron yield in one experiment compared to companion implosions with nominal tents. This article reviews and summarizes recent experiments on these alternate capsule support concepts. In addition, the concept of magnetic levitation is also discussed.

This study compared the efficacy of 4 different hamstring-stretching techniques. Flexibility can be achieved by a variety of stretching techniques, yet little research has been performed on the most effective method. The 2 basic types include active stretching, in which range of motion is increased through voluntary contraction, and passive stretching, in which range of motion is increased through external assistance. The 2 types of active stretching include neuromobilization and proprioceptive neuromuscular facilitation (PNF). Our study aims to determine which type of stretching technique is most effective in improving hamstring length. One hundred subjects between the ages of 21 and 57 were enrolled in the study. Intrarater reliability of hamstring length measurement was performed using 10 subjects. All 100 subjects were included in a randomized controlled trial of 5 different groups comparing different hamstring-stretching techniques. Outcome measures, including hamstring length and perceived level of hamstring tightness, were recorded on all subjects initially, at 4 weeks, and at 8 weeks. After 4 weeks of stretching, there was a statistically significant improvement in hamstring length (p < 0.05) using active stretches as compared with passive stretches. From weeks 4 through 8, hamstring length for the active stretching groups decreased. After 8 weeks of stretching, the straight leg raise (SLR) passive stretch group had the greatest improvement in hamstring length. There was no correlation between hamstring flexibility and age, initial tightness, or frequency of exercise per week. Improvement in hamstring flexibility was greatest for the SLR passive stretch. Also, using PNF in the 90/90 active stretch provided better knee range-of-motion improvements than the 90/90 passive methods did.

Survival, oxygen consumption ( M O2 ), total plasma cortisol and glucose levels and gill heat-shock protein 70 (hsp70) expression were measured in 10 and 50 g juvenile Atlantic cod Gadus morhua during an acute temperature increase (2° C h −1 ) to their critical thermal maximum. Ninety three per cent of the fish in both size classes survived to 24° C; however, mortality was 100% within 15 min of reaching this temperature. The M O2 for both size classes increased significantly with temperature, reaching peak values at 22° C that were c. 2·8-fold those of control (10° C) fish. Resting plasma cortisol and glucose levels were lower in 10 g as compared to 50 g fish. Plasma glucose levels were highly variable in both size classes, and significant increases were only seen at >22° C for the 10 g fish. In contrast, plasma cortisol showed an exponential increase with temperature starting at 16° C in both size classes, and reached maximum levels at 22° C that were 19-fold (10 g fish) and 35-fold (50 g fish) higher than their respective control groups. Both the constitutive (73 kDa) and inducible (72 kDa) isoforms of hsp70 were detected in both size classes using the widely utilized mouse monoclonal antibody. Expression of these isoforms, however, did not change when Atlantic cod were exposed to elevated temperature, and the 72 kDa isoform was not detected using salmonid-specific antibodies. These results indicate that juvenile Atlantic cod are very sensitive to acute increases in water temperature. In addition, they (1) show that M O2 and plasma cortisol, but not plasma glucose or gill hsp 70 levels, are sensitive indicators of thermal stress in Atlantic cod and (2) support previous reports that the upper critical temperature for this species is 16° C.

Juvenile haddock Melanogrammus aeglefinus (c. 39 g) were exposed to either a handling stressor (1 min out of water) or heat shock (increase from 10 to 15° C for 1 h), and plasma cortisol, plasma glucose and gill hsp70 levels were determined before, and at 1, 3, 6, 12, 24 and 48 h post-stress. The pattern of cortisol increase was similar following both stressors, with levels increasing by 25-fold at 1 h post-stress, but returning to pre-stress levels (2–5 ng ml−1) by 3 h. In contrast, neither handling nor heat shock caused an increase in plasma glucose levels. Although gill hsp70 was detected, presumably constitutive levels, in both control and heat shocked groups, there were not significant changes in gill hsp70 levels after exposure to heat shock. The lack of glucose and hsp70 responses to these typical stressors is consistent with previous studies on Atlantic cod Gadus morhua, and suggests that the stress physiology of Gadidae differs from the ‘typical’ teleost.

Affective or kansei design is a field of design engineering that concerns with designing emotionally pleasing products. One of the challenging issues in this area is to successfully understand customers' affective needs and to interpret it in terms of product design elements. Previous studies have attempted to obtain customer's affective needs using manual approaches, e.g. survey, which is time-consuming and a costly process. In relation, the study for such a need is usually limited to a number of product features only. In this paper, we proposed a collaborative tagging approach for discovering product features, affective description and their associations from product review analysis. Specifically, we have discussed on the tagging task assignment, tags aggregation and performance analysis of our proposal. A case study on discovering feature-affective associations from car reviews is reported to showcase the feasibility of our approach.

Nowadays, design and manufacturing companies are constantly investigating ways to offer products that are able to meet with the ever changing customer taste. Therefore, identifying customer requirements is important towards designing successful products. Recently, acquiring customer requirements from product reviews is a preferable approach that offers certain advantages over common methods such as interviews and questionnaire studies. However, uncertainty is usually a less emphasized factor in requirements modeling. This paper presents a survey on the recent achievements in identifying customer requirements from product review, with the preference uncertainty factors considered. Three main topics on identifying voice of customers (VoCs), VoCs from product reviews and uncertainty in customer requirement are explicitly discussed. Based on our extensive survey, a number of research challenges concerning the aforementioned topics have been identified and suggested. We have also briefly discussed on a few promising further research directions based on our findings.

The first experiments on the National Ignition Facility (NIF) have employed the first four beams to measure propagation and laser backscattering losses in large ignition-size plasmas. Gas-filled targets between 2 and 7 mm length have been heated from one side by overlapping the focal spots of the four beams from one quad operated at 351 nm (3ω) with a total intensity of 2 × 1015 W cm−2. The targets were filled with 1 atm of CO2 producing up to 7 mm long homogeneously heated plasmas with densities of ne = 6 × 1020 cm−3 and temperatures of Te = 2 keV. The high energy in an NIF quad of beams of 16 kJ, illuminating the target from one direction, creates unique conditions for the study of laser–plasma interactions at scale lengths not previously accessible. The propagation through the large-scale plasma was measured with a gated x-ray imager that was filtered for 3.5 keV x-rays. These data indicate that the beams interact with the full length of this ignition-scale plasma during the last ~1 ns of the experiment. During that time, the full aperture measurements of the stimulated Brillouin scattering and stimulated Raman scattering show scattering into the four focusing lenses of 3% for the smallest length (~2 mm), increasing to 10–12% for ~7 mm. These results demonstrate the NIF experimental capabilities and further provide a benchmark for three-dimensional modelling of the laser–plasma interactions at ignition-size scale lengths.

For many aquaculture finfish species, the current broodstock have been collected from the wild or have undergone only a few generations of domestication. The Atlantic halibut (Hippoglossus hippoglossus) aquaculture industry in Atlantic Canada has retained F1 juveniles (n=145) from the 1996 spawning of wild adults for candidate broodstock. Through the development and use of a five-microsatellite DNA marker multiplex, we determined the parentage of these 1996 F1 individuals, which are being reared at one government and two industry hatcheries, and evaluated the change in genetic variation between the wild and the 1996 F1 stock. In the three groups of F1 fish, single parental pairs were assigned to 98%, 96% and 100% of individuals. Large full- and half-sibling groups were identified within and across F1 groups and, overall, only 36% of attempted crosses were represented in the retained fish. Effective population size in the parental group decreased from 27 to 13 when variance in family size was accounted for and to 12.5 when changes in gene diversity (compared to the combined F1 stocks) were considered. Statistically significant differences in measures of genetic variation were not widely observed between groups (original wild sample, parental group, three F1 groups and combined F1). However, the F1 population shows a 26% decrease in total allele numbers compared to the wild sample. These observations demonstrate the utility of genetic tools in the evaluation of genetic diversity and determination of pedigree during the establishment of new broodstock. They also emphasize the necessity for closely monitoring future matings among these fish and suggest the need to introduce additional genetic variation into this group of Atlantic halibut broodstock.

Data handling in PHENIX is carried out by the On-Line Computing System (ONCS) and Off-Line Computing System (Off-Line). ONCS provides the overall control and monitoring of the front-end electronics, trigger and data acquisition system and detector ancillary systems. It configures and initializes the on-line system, monitors and controls the data flow, coordinates calibration processes, interlocks the data acquisition process with the slow control subsystems and performs a number of other functions. ONCS uses CORBA software to monitor and control the hardware. Off-Line provides all aspects of data handling not directly connected to the collection of data and monitoring, such as event simulation and reconstruction, data analysis and information management. The impact of the unprecedented data volumes on the design is presented, along with a detailed discussion of the tasks and methods of simulating, obtaining and monitoring the data.

The PHENIX tracking system consists of Drift Chambers (DC), Pad Chambers (PC) and the Time Expansion Chamber (TEC). PC1/DC and PC2/TEC/PC3 form the inner and outer tracking units, respectively. These units link the track segments that transverse the RICH and extend to the EMCal. The DC measures charged particle trajectories in the r-phi direction to determine P-T of the particles and the invariant mass of particle pairs. The PCs perform 3D spatial point measurements for pattern recognition and longitudinal momentum reconstruction and provide spatial resolution of a few mm in both r-phi and z. The TEC tracks particles passing through the region between the RICH and the EMCal. The design and operational parameters of the detectors are presented and running experience during the first year of data taking with PHENIX is discussed. The observed spatial and momentum resolution is given which imposes a limitation on the identification and characterization of charged particles in various momentum ranges. (C) 2002 Published by Elsevier Science B.V.

This study compared the effects of pre-exercise cooling with control water immersions on exercise-induced thermal loads derived from steady-state submaximal exercise. Eight healthy male participants [mean (SEM) age 29 (1) years, maximal oxygen uptake 3.81 (0.74) l x min(-1), and body surface area 1.85 (0.11) m(2)] took part in experiments that included 30 min of baseline data collection [ambient temperature 21.3 (0.2 degrees C)], 30 min of immersion in water to the level of the supra-iliac crest [water temperatures of 35.1 (0.3) degrees C for thermoneutral and 17.7 (0.5) degrees C for precooled treatments], and 60 min of cycling exercise at 60% of maximal oxygen uptake. No significant differences were noted during exercise in net mechanical efficiency, metabolic rate, O(2) pulse, or ratings of perceived exertion between the two treatments. Precooling resulted in a significant negative body heat storage during immersion and allowed greater heat storage during exercise. However, net body heat storage for the entire protocol was no different between treatments. Cooling significantly lowered rectal, mean skin, and mean body temperatures as well as more than doubling the exercise time until a 0.5 degrees C rectal temperature increase was observed. The cooling trial significantly delayed onset of sweating by 19.62 min and decreased sweat rate by 255 ml x h(-1) compared to control. Thermal and sweat sensation scores were lower after the cooling treatment compared to control. These data suggest that lower-body precooling is effective at decreasing body heat storage prior to exercise and decreases reliance on heat dissipation mechanisms during exercise. Therefore, this unique, well-tolerated cooling treatment should have a broader application than other precooling treatments.

First identical-pion correlations measured at RHIC energies by PHENIX are presented. Two analyses with separate detectors, systematics, and statistics provide consistent results. The resulting HBT radii are moderately larger than those measured at lower energies. The $k_t$ dependence of the Bertsch-Pratt HBT radii is also similar to previous measures and is consistent with the conjecture of an expanding source., Comment: Contribution to Quark Matter 2001, Long Island, New York, January 15-20, 2001

Measurements of the midrapidity transverse-energy distribution, dE(T)/d eta, are presented for p + p, d+Au, and Au+Au collisions atv root s(NN) = 200 GeV and additionally for Au+Au collisions atv root s(NN) = 62.4 and 130 GeV. The dE(T)/d eta distributions are first compared with the number of nucleon participants N-part, number of binary collisions N-coll, and number of constituent-quark participants N-qp calculated from a Glauber model based on the nuclear geometry. For Au+Au, /N-part increases with N-part, while /N-qp is approximately constant for all three energies. This indicates that the two-component ansatz, dE(T)/d eta alpha (1 - x)N-part/2 + xN(coll), which was used to represent E-T distributions, is simply a proxy for N-qp, and that the N-coll term does not represent a hard-scattering component in E-T distributions. The dE(T)/d eta distributions of Au+Au and d+Au are then calculated from the measured p + p E-T distribution using two models that both reproduce the Au+Au data. However, while the number-of-constituent-quark-participant model agrees well with the d+Au data, the additive-quark model does not.

We present results for the charged-particle multiplicity distribution at midrapidity in Au-Au collisions at square root of [s(NN)] = 130 GeV measured with the PHENIX detector at RHIC. For the 5% most central collisions we find dN(ch)/d eta(vertical line eta = 0) = 622+/-1(stat)+/-41(syst). The results, analyzed as a function of centrality, show a steady rise of the particle density per participating nucleon with centrality.

Objective.In 1993, Children's Healthcare of Atlanta at Scottish Rite (formery Scottish Rite Children's Medical Center, Atlanta, GA) added facilities to perform inpatient covert video surveillance (CVS) of suspected cases of Munchausen syndrome by proxy (MSBP). Forty-one patients were monitored from 1993 to 1997. This study was performed to review our experience with these cases. How useful was video surveillance in making the diagnosis? What were the characteristics of families with children who were victims of MSBP?Methodology.Medical, social work, security, and administrative records of all children who underwent covert video monitoring at Children's Healthcare of Atlanta at Scottish Rite from 1993 through 1997 were reviewed retrospectively by a team of physicians, risk managers, and social workers.Results.A diagnosis of MSBP was made in 23 of 41 patients monitored. CVS was required to make the diagnosis in 13 (56.1%) of these 23, and supportive of the diagnosis in 5 (21.7%) cases. In 4 patients, this surveillance was instrumental in establishing innocence of the parents. MSBP was more common in Caucasian patients than in other ethnic groups seen at our hospital. Fifty-five percent of mothers gave a history of health care work or study, and another 25% had previously worked in day care. Although many of caretakers fit the profile of MSBP, such as excessive familiarity with medical staff, eagerness for invasive medical testing, and history of health care work, these characteristics were not sensitive indicators of MSBP in our study. Even when present, they were not sufficiently compelling to make the diagnosis.Conclusions.CVS is required to make a definitive and timely diagnosis in most cases of MSBP. Without this medical diagnostic tool, many cases will go undetected, placing children at risk. All tertiary care children's hospitals should develop facilities to perform CVS in suspected cases.

We constructed and tested a threshold Cherenkov detector (inspired by the conceptual design of Giomataris and Charpak (Nucl. Instr. and Meth. A 310 (1991) 589 ) consisting of a gas radiator followed by a photosensitive wire chamber using a solid CsI photocathode. The detector was operated with C2F6 radiator gas and a 95%He+5%CH4 mixture for the avalanche gas. At 95% electron efficiency, the pion efficiency was 1 333 , 1 150 , and 1 100 for each of the lengths listed above.

Scavenger receptor class B type I (SR-BI) mediates the selective uptake of high density lipoprotein cholesterol. SR-BI is expressed at high levels in the ovary, indicating that it plays a role in the delivery of cholesterol as substrate for steroid hormone production. However, SR-BI also binds anionic phospholipids with high affinity and could therefore be involved in the recognition of apoptotic cells. In this study we have characterized the expression of SR-BI in rat ovarian follicles undergoing atresia. Atretic follicles with cells undergoing apoptosis were identified by in situ DNA end labeling, and SR-BI expression was determined by in situ hybridization and immunohistochemistry. SR-BI was expressed in thecal cells at all stages of follicular development, including atretic follicles, and in corpus luteum. Isolated apoptotic granulosa cells (but not viable granulosa cells) bound annexin V, indicating that they display anionic phospholipids on the cell surface. Transfection of COS-7 cells with an expression vector carrying the rat SR-BI complementary DNA resulted in increased binding to apoptotic granulosa cells (46 ± 2% of the SR-BI-expressing cells bound at least one granulosa cell compared with 24 ± 3% for the mock-transfected cells; P < 0.0001), whereas the binding to viable granulosa cells was unchanged. Apoptotic granulosa cells also bound to isolated thecal shells. We conclude that thecal cells of both nonatretic and atretic follicles express SR-BI. The location of SR-BI expression in the ovary supports a role of this receptor in the uptake of high density lipoprotein cholesterol. In addition, our data suggest that SR-BI mediates the recognition of apoptotic granulosa cells by the surrounding thecal cells and that it therefore may play a role in the remodeling of atretic follicles to secondary interstitial cells.

Objective To investigate the increase in oxidative stress during work at moderate altitudes due to additional energy expenditure, tissue anoxia, and UV light exposure. Methods Thirty US Marine Corps volunteers were divided into placebo (P) and antioxidant supplement (S) groups and tested for markers of oxidative stress before ( t 0 ) , at the midpoint of ( t 1 ), and after ( t 2 ) 14 days of winter training at a moderate altitude (∼2700m). The antioxidant supplement consisted of a daily dose of 20 000 IU β-carotene, 400 IU vitamin E, 500mg vitamin C, 100μg selenium, and 30mg zinc. The following markers of oxidative stress were measured: urine thiobarbituric acid reactive substances (TBARSs), urine hydroxynonenal (HNE), urine 8-hydrodeoxyguanosine (8-OHdG), plasma total peroxyl radical trapping potential (TRAP), and plasma lipid hydroperoxides (LPOs). Urine was collected on a 24-hr basis at t 0 , t 1 and t 2 ; blood samples were collected at t 0 and t 2 . Results P group LPOs increased 30% ( p t 0 and t 2 , whereas S group LPOs did not increase. Both groups exhibited significant increases in urine TBARSs, HNE, and 8-OHdG by t 2 . Urine TBARSs, HNE, and 8-OHdG increased between t 0 and t 1 in both groups, with the greater increase in the S group. The conflicting results between the plasma and urine markers of oxidative stress may be due to a time-phase relationship. Conclusions The results of this study suggest that work in a moderate-altitude cold-weather environment is accompanied by increased oxidative stress, despite relatively high intakes of dietary and supplemental antioxidants.

Directed flow of deuterons, tritons, ${}^{3}\mathrm{He},$ and ${}^{4}\mathrm{He}$ is studied in Au+Au collisions at a beam momentum of $10.8A\mathrm{GeV}/c.$ Flow of all particles is analyzed as a function of transverse momentum for different centralities of the collision. The directed flow signal, ${v}_{1}{(p}_{t}),$ is found to increase with particle mass. This mass dependence is strongest in the projectile rapidity region.