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1. DUE CASI DI MENINGO/ENCEFALITE DA L. MONOCYTOGENES: ATTUALITÀ DEL SISTEMA DI SORVEGLIANZA DELLE LISTERIOSI

Author: S. Boni, S. Artioli, C. Amodeo, A. Derchi, E. Battola, and M. Dono
Subjects: Microbiology, QR1-502
Published: 2007
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2. Impact of diabetes on the management and outcomes in atrial fibrillation:an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

Author: Wern Yew Ding, Agnieszka Kotalczyk, Giuseppe Boriani, Francisco Marin, Carina Blomström-Lundqvist, Tatjana S. Potpara, Laurent Fauchier, Gregory.Y.H. Lip, G. Boriani, G.Y.H. Lip, L. Tavazzi, A.P. Maggioni, G.-A. Dan, T. Potpara, M. Nabauer, F. Marin, Z. Kalarus, A. Goda, G. Mairesse, T. Shalganov, L. Antoniades, M. Taborsky, S. Riahi, P. Muda, I. García Bolao, O. Piot, K. Etsadashvili, E. Simantirakis, M. Haim, A. Azhari, J. Najafian, M. Santini, E. Mirrakhimov, K.A. Kulzida, A. Erglis, L. Poposka, M. Burg, H. Crijns, Ö. Erküner, D. Atar, R. Lenarczyk, M. Martins Oliveira, D. Shah, E. Serdechnaya, E. Diker, D. Lane, E. Zëra, U. Ekmekçiu, V. Paparisto, M. Tase, H. Gjergo, J. Dragoti, M. Ciutea, N. Ahadi, Z. el Husseini, M. Raepers, J. Leroy, P. Haushan, A. Jourdan, C. Lepiece, L. Desteghe, J. Vijgen, P. Koopman, G. Van Genechten, H. Heidbuchel, T. Boussy, M. De Coninck, H. Van Eeckhoutte, N. Bouckaert, A. Friart, J. Boreux, C. Arend, P. Evrard, L. Stefan, E. Hoffer, J. Herzet, M. Massoz, C. Celentano, M. Sprynger, L. Pierard, P. Melon, B. Van Hauwaert, C. Kuppens, D. Faes, D. Van Lier, A. Van Dorpe, A. Gerardy, O. Deceuninck, O. Xhaet, F. Dormal, E. Ballant, D. Blommaert, D. Yakova, M. Hristov, T. Yncheva, N. Stancheva, S. Tisheva, M. Tokmakova, F. Nikolov, D. Gencheva, B. Kunev, M. Stoyanov, D. Marchov, V. Gelev, V. Traykov, A. Kisheva, H. Tsvyatkov, R. Shtereva, S. Bakalska-Georgieva, S. Slavcheva, Y. Yotov, M. Kubíčková, A. Marni Joensen, A. Gammelmark, L. Hvilsted Rasmussen, P. Dinesen, S. Krogh Venø, B. Sorensen, A. Korsgaard, K. Andersen, C. Fragtrup Hellum, A. Svenningsen, O. Nyvad, P. Wiggers, O. May, A. Aarup, B. Graversen, L. Jensen, M. Andersen, M. Svejgaard, S. Vester, S. Hansen, V. Lynggaard, M. Ciudad, R. Vettus, A. Maestre, S. Castaño, S. Cheggour, J. Poulard, V. Mouquet, S. Leparrée, J. Bouet, J. Taieb, A. Doucy, H. Duquenne, A. Furber, J. Dupuis, J. Rautureau, M. Font, P. Damiano, M. Lacrimini, J. Abalea, S. Boismal, T. Menez, J. Mansourati, G. Range, H. Gorka, C. Laure, C. Vassalière, N. Elbaz, N. Lellouche, K. Djouadi, F. Roubille, D. Dietz, J. Davy, M. Granier, P. Winum, C. Leperchois-Jacquey, H. Kassim, E. Marijon, J. Le Heuzey, J. Fedida, C. Maupain, C. Himbert, E. Gandjbakhch, F. Hidden-Lucet, G. Duthoit, N. Badenco, T. Chastre, X. Waintraub, M. Oudihat, J. Lacoste, C. Stephan, H. Bader, N. Delarche, L. Giry, D. Arnaud, C. Lopez, F. Boury, I. Brunello, M. Lefèvre, R. Mingam, M. Haissaguerre, M. Le Bidan, D. Pavin, V. Le Moal, C. Leclercq, T. Beitar, I. Martel, A. Schmid, N. Sadki, C. Romeyer-Bouchard, A. Da Costa, I. Arnault, M. Boyer, C. Piat, N. Lozance, S. Nastevska, A. Doneva, B. Fortomaroska Milevska, B. Sheshoski, K. Petroska, N. Taneska, N. Bakrecheski, K. Lazarovska, S. Jovevska, V. Ristovski, A. Antovski, E. Lazarova, I. Kotlar, J. Taleski, S. Kedev, N. Zlatanovik, S. Jordanova, T. Bajraktarova Proseva, S. Doncovska, D. Maisuradze, A. Esakia, E. Sagirashvili, K. Lartsuliani, N. Natelashvili, N. Gumberidze, R. Gvenetadze, N. Gotonelia, N. Kuridze, G. Papiashvili, I. Menabde, S. Glöggler, A. Napp, C. Lebherz, H. Romero, K. Schmitz, M. Berger, M. Zink, S. Köster, J. Sachse, E. Vonderhagen, G. Soiron, K. Mischke, R. Reith, M. Schneider, W. Rieker, D. Boscher, A. Taschareck, A. Beer, D. Oster, O. Ritter, J. Adamczewski, S. Walter, A. Frommhold, E. Luckner, J. Richter, M. Schellner, S. Landgraf, S. Bartholome, R. Naumann, J. Schoeler, D. Westermeier, F. William, K. Wilhelm, M. Maerkl, R. Oekinghaus, M. Denart, M. Kriete, U. Tebbe, T. Scheibner, M. Gruber, A. Gerlach, C. Beckendorf, L. Anneken, M. Arnold, S. Lengerer, Z. Bal, C. Uecker, H. Förtsch, S. Fechner, V. Mages, E. Martens, H. Methe, T. Schmidt, B. Schaeffer, B. Hoffmann, J. Moser, K. Heitmann, S. Willems, C. Klaus, I. Lange, M. Durak, E. Esen, F. Mibach, H. Mibach, A. Utech, M. Gabelmann, R. Stumm, V. Ländle, C. Gartner, C. Goerg, N. Kaul, S. Messer, D. Burkhardt, C. Sander, R. Orthen, S. Kaes, A. Baumer, F. Dodos, A. Barth, G. Schaeffer, J. Gaertner, J. Winkler, A. Fahrig, J. Aring, I. Wenzel, S. Steiner, A. Kliesch, E. Kratz, K. Winter, P. Schneider, A. Haag, I. Mutscher, R. Bosch, J. Taggeselle, S. Meixner, A. Schnabel, A. Shamalla, H. Hötz, A. Korinth, C. Rheinert, G. Mehltretter, B. Schön, N. Schön, A. Starflinger, E. Englmann, G. Baytok, T. Laschinger, G. Ritscher, A. Gerth, D. Dechering, L. Eckardt, M. Kuhlmann, N. Proskynitopoulos, J. Brunn, K. Foth, C. Axthelm, H. Hohensee, K. Eberhard, S. Turbanisch, N. Hassler, A. Koestler, G. Stenzel, D. Kschiwan, M. Schwefer, S. Neiner, S. Hettwer, M. Haeussler-Schuchardt, R. Degenhardt, S. Sennhenn, M. Brendel, A. Stoehr, W. Widjaja, S. Loehndorf, A. Logemann, J. Hoskamp, J. Grundt, M. Block, R. Ulrych, A. Reithmeier, V. Panagopoulos, C. Martignani, D. Bernucci, E. Fantecchi, I. Diemberger, M. Ziacchi, M. Biffi, P. Cimaglia, J. Frisoni, I. Giannini, S. Boni, S. Fumagalli, S. Pupo, A. Di Chiara, P. Mirone, F. Pesce, C. Zoccali, V.L. Malavasi, A. Mussagaliyeva, B. Ahyt, Z. Salihova, K. Koshum-Bayeva, A. Kerimkulova, A. Bairamukova, B. Lurina, R. Zuzans, S. Jegere, I. Mintale, K. Kupics, K. Jubele, O. Kalejs, K. Vanhear, M. Cachia, E. Abela, S. Warwicker, T. Tabone, R. Xuereb, D. Asanovic, D. Drakalovic, M. Vukmirovic, N. Pavlovic, L. Music, N. Bulatovic, A. Boskovic, H. Uiterwaal, N. Bijsterveld, J. De Groot, J. Neefs, N. van den Berg, F. Piersma, A. Wilde, V. Hagens, J. Van Es, J. Van Opstal, B. Van Rennes, H. Verheij, W. Breukers, G. Tjeerdsma, R. Nijmeijer, D. Wegink, R. Binnema, S. Said, S. Philippens, W. van Doorn, T. Szili-Torok, R. Bhagwandien, P. Janse, A. Muskens, M. van Eck, R. Gevers, N. van der Ven, A. Duygun, B. Rahel, J. Meeder, A. Vold, C. Holst Hansen, I. Engset, B. Dyduch-Fejklowicz, E. Koba, M. Cichocka, A. Sokal, A. Kubicius, E. Pruchniewicz, A. Kowalik-Sztylc, W. Czapla, I. Mróz, M. Kozlowski, T. Pawlowski, M. Tendera, A. Winiarska-Filipek, A. Fidyk, A. Slowikowski, M. Haberka, M. Lachor-Broda, M. Biedron, Z. Gasior, M. Kołodziej, M. Janion, I. Gorczyca-Michta, B. Wozakowska-Kaplon, M. Stasiak, P. Jakubowski, T. Ciurus, J. Drozdz, M. Simiera, P. Zajac, T. Wcislo, P. Zycinski, J. Kasprzak, A. Olejnik, E. Harc-Dyl, J. Miarka, M. Pasieka, M. Ziemińska-Łuć, W. Bujak, A. Śliwiński, A. Grech, J. Morka, K. Petrykowska, M. Prasał, G. Hordyński, P. Feusette, P. Lipski, A. Wester, W. Streb, J. Romanek, P. Woźniak, M. Chlebuś, P. Szafarz, W. Stanik, M. Zakrzewski, J. Kaźmierczak, A. Przybylska, E. Skorek, H. Błaszczyk, M. Stępień, S. Szabowski, W. Krysiak, M. Szymańska, J. Karasiński, J. Blicharz, M. Skura, K. Hałas, L. Michalczyk, Z. Orski, K. Krzyżanowski, A. Skrobowski, L. Zieliński, M. Tomaszewska-Kiecana, M. Dłużniewski, M. Kiliszek, M. Peller, M. Budnik, P. Balsam, G. Opolski, A. Tymińska, K. Ozierański, A. Wancerz, A. Borowiec, E. Majos, R. Dabrowski, H. Szwed, A. Musialik-Lydka, A. Leopold-Jadczyk, E. Jedrzejczyk-Patej, M. Koziel, M. Mazurek, K. Krzemien-Wolska, P. Starosta, E. Nowalany-Kozielska, A. Orzechowska, M. Szpot, M. Staszel, S. Almeida, H. Pereira, L. Brandão Alves, R. Miranda, L. Ribeiro, F. Costa, F. Morgado, P. Carmo, P. Galvao Santos, R. Bernardo, P. Adragão, G. Ferreira da Silva, M. Peres, M. Alves, M. Leal, A. Cordeiro, P. Magalhães, P. Fontes, S. Leão, A. Delgado, A. Costa, B. Marmelo, B. Rodrigues, D. Moreira, J. Santos, L. Santos, A. Terchet, D. Darabantiu, S. Mercea, V. Turcin Halka, A. Pop Moldovan, A. Gabor, B. Doka, G. Catanescu, H. Rus, L. Oboroceanu, E. Bobescu, R. Popescu, A. Dan, A. Buzea, I. Daha, G. Dan, I. Neuhoff, M. Baluta, R. Ploesteanu, N. Dumitrache, M. Vintila, A. Daraban, C. Japie, E. Badila, H. Tewelde, M. Hostiuc, S. Frunza, E. Tintea, D. Bartos, A. Ciobanu, I. Popescu, N. Toma, C. Gherghinescu, D. Cretu, N. Patrascu, C. Stoicescu, C. Udroiu, G. Bicescu, V. Vintila, D. Vinereanu, M. Cinteza, R. Rimbas, M. Grecu, A. Cozma, F. Boros, M. Ille, O. Tica, R. Tor, A. Corina, A. Jeewooth, B. Maria, C. Georgiana, C. Natalia, D. Alin, D. Dinu-Andrei, M. Livia, R. Daniela, R. Larisa, S. Umaar, T. Tamara, M. Ioachim Popescu, D. Nistor, I. Sus, O. Coborosanu, N. Alina-Ramona, R. Dan, L. Petrescu, G. Ionescu, C. Vacarescu, E. Goanta, M. Mangea, A. Ionac, C. Mornos, D. Cozma, S. Pescariu, E. Solodovnicova, I. Soldatova, J. Shutova, L. Tjuleneva, T. Zubova, V. Uskov, D. Obukhov, G. Rusanova, N. Isakova, S. Odinsova, T. Arhipova, E. Kazakevich, O. Zavyalova, T. Novikova, I. Riabaia, S. Zhigalov, E. Drozdova, I. Luchkina, Y. Monogarova, D. Hegya, L. Rodionova, V. Nevzorova, O. Lusanova, A. Arandjelovic, D. Toncev, L. Vukmirovic, M. Radisavljevic, M. Milanov, N. Sekularac, M. Zdravkovic, S. Hinic, S. Dimkovic, T. Acimovic, J. Saric, S. Radovanovic, A. Kocijancic, B. Obrenovic-Kircanski, D. Kalimanovska Ostric, D. Simic, I. Jovanovic, I. Petrovic, M. Polovina, M. Vukicevic, M. Tomasevic, N. Mujovic, N. Radivojevic, O. Petrovic, S. Aleksandric, V. Kovacevic, Z. Mijatovic, B. Ivanovic, M. Tesic, A. Ristic, B. Vujisic-Tesic, M. Nedeljkovic, A. Karadzic, A. Uscumlic, M. Prodanovic, M. Zlatar, M. Asanin, B. Bisenic, V. Vasic, Z. Popovic, D. Djikic, M. Sipic, V. Peric, B. Dejanovic, N. Milosevic, S. Backovic, A. Stevanovic, A. Andric, B. Pencic, M. Pavlovic-Kleut, V. Celic, M. Pavlovic, M. Petrovic, M. Vuleta, N. Petrovic, S. Simovic, Z. Savovic, S. Milanov, G. Davidovic, V. Iric-Cupic, D. Djordjevic, M. Damjanovic, S. Zdravkovic, V. Topic, D. Stanojevic, M. Randjelovic, R. Jankovic-Tomasevic, V. Atanaskovic, S. Antic, D. Simonovic, M. Stojanovic, S. Stojanovic, V. Mitic, V. Ilic, D. Petrovic, M. Deljanin Ilic, S. Ilic, V. Stoickov, S. Markovic, A. Mijatovic, D. Tanasic, G. Radakovic, J. Peranovic, N. Panic-Jelic, O. Vujadinovic, P. Pajic, S. Bekic, S. Kovacevic, A. García Fernandez, A. Perez Cabeza, M. Anguita, L. Tercedor Sanchez, E. Mau, J. Loayssa, M. Ayarra, M. Carpintero, I. Roldán Rabadan, M. Gil Ortega, A. Tello Montoliu, E. Orenes Piñero, S. Manzano Fernández, F. Marín, A. Romero Aniorte, A. Veliz Martínez, M. Quintana Giner, G. Ballesteros, M. Palacio, O. Alcalde, I. García-Bolao, V. Bertomeu Gonzalez, F. Otero-Raviña, J. García Seara, J. Gonzalez Juanatey, N. Dayal, P. Maziarski, P. Gentil-Baron, M. Koç, E. Onrat, I.E. Dural, K. Yilmaz, B. Özin, S. Tan Kurklu, Y. Atmaca, U. Canpolat, L. Tokgozoglu, A.K. Dolu, B. Demirtas, D. Sahin, O. Ozcan Celebi, G. Gagirci, U.O. Turk, H. Ari, N. Polat, N. Toprak, M. Sucu, O. Akin Serdar, A. Taha Alper, A. Kepez, Y. Yuksel, A. Uzunselvi, S. Yuksel, M. Sahin, O. Kayapinar, T. Ozcan, H. Kaya, M.B. Yilmaz, M. Kutlu, M. Demir, C. Gibbs, S. Kaminskiene, M. Bryce, A. Skinner, G. Belcher, J. Hunt, L. Stancombe, B. Holbrook, C. Peters, S. Tettersell, A. Shantsila, K. Senoo, M. Proietti, K. Russell, P. Domingos, S. Hussain, J. Partridge, R. Haynes, S. Bahadur, R. Brown, S. McMahon, J. McDonald, K. Balachandran, R. Singh, S. Garg, H. Desai, K. Davies, W. Goddard, G. Galasko, I. Rahman, Y. Chua, O. Payne, S. Preston, O. Brennan, L. Pedley, C. Whiteside, C. Dickinson, J. Brown, K. Jones, L. Benham, R. Brady, L. Buchanan, A. Ashton, H. Crowther, H. Fairlamb, S. Thornthwaite, C. Relph, A. McSkeane, U. Poultney, N. Kelsall, P. Rice, T. Wilson, M. Wrigley, R. Kaba, T. Patel, E. Young, J. Law, C. Runnett, H. Thomas, H. McKie, J. Fuller, S. Pick, A. Sharp, A. Hunt, K. Thorpe, C. Hardman, E. Cusack, L. Adams, M. Hough, S. Keenan, A. Bowring, J. Watts, J. Zaman, K. Goffin, H. Nutt, Y. Beerachee, J. Featherstone, C. Mills, J. Pearson, L. Stephenson, S. Grant, A. Wilson, C. Hawksworth, I. Alam, M. Robinson, S. Ryan, R. Egdell, E. Gibson, M. Holland, D. Leonard, B. Mishra, S. Ahmad, H. Randall, J. Hill, L. Reid, M. George, S. McKinley, L. Brockway, W. Milligan, J. Sobolewska, J. Muir, L. Tuckis, L. Winstanley, P. Jacob, S. Kaye, L. Morby, A. Jan, T. Sewell, C. Boos, B. Wadams, C. Cope, P. Jefferey, N. Andrews, A. Getty, A. Suttling, C. Turner, K. Hudson, R. Austin, S. Howe, R. Iqbal, N. Gandhi, K. Brophy, P. Mirza, E. Willard, S. Collins, N. Ndlovu, E. Subkovas, V. Karthikeyan, L. Waggett, A. Wood, A. Bolger, J. Stockport, L. Evans, E. Harman, J. Starling, L. Williams, V. Saul, M. Sinha, L. Bell, S. Tudgay, S. Kemp, L. Frost, T. Ingram, A. Loughlin, C. Adams, M. Adams, F. Hurford, C. Owen, C. Miller, D. Donaldson, H. Tivenan, H. Button, A. Nasser, O. Jhagra, B. Stidolph, C. Brown, C. Livingstone, M. Duffy, P. Madgwick, P. Roberts, E. Greenwood, L. Fletcher, M. Beveridge, S. Earles, D. McKenzie, D. Beacock, M. Dayer, M. Seddon, D. Greenwell, F. Luxton, F. Venn, H. Mills, J. Rewbury, K. James, K. Roberts, L. Tonks, D. Felmeden, W. Taggu, A. Summerhayes, D. Hughes, J. Sutton, L. Felmeden, M. Khan, E. Walker, L. Norris, L. O'Donohoe, A. Mozid, H. Dymond, H. Lloyd-Jones, G. Saunders, D. Simmons, D. Coles, D. Cotterill, S. Beech, S. Kidd, B. Wrigley, S. Petkar, A. Smallwood, R. Jones, E. Radford, S. Milgate, S. Metherell, V. Cottam, C. Buckley, A. Broadley, D. Wood, J. Allison, K. Rennie, L. Balian, L. Howard, L. Pippard, S. Board, T. Pitt-Kerby, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Océan du Large et Variabilité Climatique (OLVAC), Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Uppsala University, University of Belgrade [Belgrade], CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), and Université de Tours (UT)
Subjects: Kardiologi, General Practice, Cohort, Anticoagulants, MACE, Endocrinology and Diabetes, Prognosis, [SHS]Humanities and Social Sciences, Allmänmedicin, Stroke, Risk Factors, Healthcare resource utilisation, Mortality, Prevalence, Endokrinologi och diabetes, Atrial Fibrillation, Internal Medicine, Diabetes Mellitus, Quality of Life, Humans, Cardiac and Cardiovascular Systems, Prospective Studies, Registries, Aged
Abstract: BACKGROUND: The prevalence of atrial fibrillation(AF) and diabetes mellitus is rising to epidemic proportions. We aimed to assess the impact of diabetes on the management and outcomes of patients with AF.METHODS: The EORP-AF General Long-Term Registry is a prospective, observational registry from 250 centres across 27 European countries. Outcomes of interest were as follows: i)rhythm control interventions; ii)quality of life; iii)healthcare resource utilisation; and iv)major adverse events.RESULTS: Of 11,028 patients with AF, the median age was 71 (63-77) years and 2537 (23.0%) had diabetes. Median follow-up was 24 months. Diabetes was related to increased use of anticoagulation but less rhythm control interventions. Using multivariable analysis, at 2-year follow-up, patients with diabetes were associated with greater levels of anxiety (p = 0.038) compared to those without diabetes. Overall, diabetes was associated with worse health during follow-up, as indicated by Health Utility Score and Visual Analogue Scale. Healthcare resource utilisation was greater with diabetes in terms of length of hospital stay (8.1 (±8.2) vs. 6.1 (±6.7) days); cardiology and internal medicine/general practitioner visits; and emergency room admissions. Diabetes was an independent risk factor of major adverse cardiovascular event (MACE; HR 1.26 [95% CI, 1.04-1.52]), all-cause mortality (HR 1.28 [95% CI, 1.08-1.52]), and cardiovascular mortality (HR 1.41 [95% CI, 1.09-1.83]).CONCLUSION: In this contemporary AF cohort, diabetes was present in 1 in 4 patients and it served as an independent risk factor for reduced quality of life, greater healthcare resource utilisation and excess MACE, all-cause mortality and cardiovascular mortality. There was increased use of anticoagulation therapy in diabetes but with less rhythm control interventions.
Published: 2022
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3. Down Syndrome and COVID-19: not always a poor prognosis

Author: A. Parisini, S. Boni, E Blasi Vacca, F. Del Puente, M. Feasi, N. Bobbio, R. Prinapori, C. Bolla, M. Castellaneta, E. Pontali, and G. Chichino
Subjects: Pulmonary and Respiratory Medicine, Infectious Diseases, SARS-CoV-2, COVID-19, Humans, Down Syndrome, Prognosis
Published: 2022

4. Cardiac troponins and adverse outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EORP atrial fibrillation general long-term registry

Author: Marco Vitolo, Vincenzo L. Malavasi, Marco Proietti, Igor Diemberger, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Luigi Tavazzi, Aldo Pietro Maggioni, Deirdre A. Lane, Gregory Y.H. Lip, Giuseppe Boriani, G. Boriani, G.Y.H. Lip, L. Tavazzi, A.P. Maggioni, G-A. Dan, T. Potpara, M. Nabauer, F. Marin, Z. Kalarus, L. Fauchier, A. Goda, G. Mairesse, T. Shalganov, L. Antoniades, M. Taborsky, S. Riahi, P. Muda, I. García Bolao, O. Piot, K. Etsadashvili, M. Haim, A. Azhari, J. Najafian, M. Santini, E. Mirrakhimov, K. Kulzida, A. Erglis, L. Poposka, M.R. Burg, H. Crijns, Ö. Erküner, D. Atar, R. Lenarczyk, M. Martins Oliveira, D. Shah, E. Serdechnaya, E. Diker, E. Zëra, U. Ekmekçiu, V. Paparisto, M. Tase, H. Gjergo, J. Dragoti, M. Ciutea, N. Ahadi, Z. el Husseini, M. Raepers, J. Leroy, P. Haushan, A. Jourdan, C. Lepiece, L. Desteghe, J. Vijgen, P. Koopman, G. Van Genechten, H. Heidbuchel, T. Boussy, M. De Coninck, H. Van Eeckhoutte, N. Bouckaert, A. Friart, J. Boreux, C. Arend, P. Evrard, L. Stefan, E. Hoffer, J. Herzet, M. Massoz, C. Celentano, M. Sprynger, L. Pierard, P. Melon, B. Van Hauwaert, C. Kuppens, D. Faes, D. Van Lier, A. Van Dorpe, A. Gerardy, O. Deceuninck, O. Xhaet, F. Dormal, E. Ballant, D. Blommaert, D. Yakova, M. Hristov, T. Yncheva, N. Stancheva, S. Tisheva, M. Tokmakova, F. Nikolov, D. Gencheva, B. Kunev, M. Stoyanov, D. Marchov, V. Gelev, V. Traykov, A. Kisheva, H. Tsvyatkov, R. Shtereva, S. Bakalska-Georgieva, S. Slavcheva, Y. Yotov, M. Kubíčková, A. Marni Joensen, A. Gammelmark, L. Hvilsted Rasmussen, P. Dinesen, S. Krogh Venø, B. Sorensen, A. Korsgaard, K. Andersen, C. Fragtrup Hellum, A. Svenningsen, O. Nyvad, P. Wiggers, O. May, A. Aarup, B. Graversen, L. Jensen, M. Andersen, M. Svejgaard, S. Vester, S. Hansen, V. Lynggaard, M. Ciudad, R. Vettus, A. Maestre, S. Castaño, S. Cheggour, J. Poulard, V. Mouquet, S. Leparrée, J. Bouet, J. Taieb, A. Doucy, H. Duquenne, A. Furber, J. Dupuis, J. Rautureau, M. Font, P. Damiano, M. Lacrimini, J. Abalea, S. Boismal, T. Menez, J. Mansourati, G. Range, H. Gorka, C. Laure, C. Vassalière, N. Elbaz, N. Lellouche, K. Djouadi, F. Roubille, D. Dietz, J. Davy, M. Granier, P. Winum, C. Leperchois-Jacquey, H. Kassim, E. Marijon, J. Le Heuzey, J. Fedida, C. Maupain, C. Himbert, E. Gandjbakhch, F. Hidden-Lucet, G. Duthoit, N. Badenco, T. Chastre, X. Waintraub, M. Oudihat, J. Lacoste, C. Stephan, H. Bader, N. Delarche, L. Giry, D. Arnaud, C. Lopez, F. Boury, I. Brunello, M. Lefèvre, R. Mingam, M. Haissaguerre, M. Le Bidan, D. Pavin, V. Le Moal, C. Leclercq, T. Beitar, I. Martel, A. Schmid, N. Sadki, C. Romeyer-Bouchard, A. Da Costa, I. Arnault, M. Boyer, C. Piat, N. Lozance, S. Nastevska, A. Doneva, B. Fortomaroska Milevska, B. Sheshoski, K. Petroska, N. Taneska, N. Bakrecheski, K. Lazarovska, S. Jovevska, V. Ristovski, A. Antovski, E. Lazarova, I. Kotlar, J. Taleski, S. Kedev, N. Zlatanovik, S. Jordanova, T. Bajraktarova Proseva, S. Doncovska, D. Maisuradze, A. Esakia, E. Sagirashvili, K. Lartsuliani, N. Natelashvili, N. Gumberidze, R. Gvenetadze, N. Gotonelia, N. Kuridze, G. Papiashvili, I. Menabde, S. Glöggler, A. Napp, C. Lebherz, H. Romero, K. Schmitz, M. Berger, M. Zink, S. Köster, J. Sachse, E. Vonderhagen, G. Soiron, K. Mischke, R. Reith, M. Schneider, W. Rieker, D. Boscher, A. Taschareck, A. Beer, D. Oster, O. Ritter, J. Adamczewski, S. Walter, A. Frommhold, E. Luckner, J. Richter, M. Schellner, S. Landgraf, S. Bartholome, R. Naumann, J. Schoeler, D. Westermeier, F. William, K. Wilhelm, M. Maerkl, R. Oekinghaus, M. Denart, M. Kriete, U. Tebbe, T. Scheibner, M. Gruber, A. Gerlach, C. Beckendorf, L. Anneken, M. Arnold, S. Lengerer, Z. Bal, C. Uecker, H. Förtsch, S. Fechner, V. Mages, E. Martens, H. Methe, T. Schmidt, B. Schaeffer, B. Hoffmann, J. Moser, K. Heitmann, S. Willems, C. Klaus, I. Lange, M. Durak, E. Esen, F. Mibach, H. Mibach, A. Utech, M. Gabelmann, R. Stumm, V. Ländle, C. Gartner, C. Goerg, N. Kaul, S. Messer, D. Burkhardt, C. Sander, R. Orthen, S. Kaes, A. Baumer, F. Dodos, A. Barth, G. Schaeffer, J. Gaertner, J. Winkler, A. Fahrig, J. Aring, I. Wenzel, S. Steiner, A. Kliesch, E. Kratz, K. Winter, P. Schneider, A. Haag, I. Mutscher, R. Bosch, J. Taggeselle, S. Meixner, A. Schnabel, A. Shamalla, H. Hötz, A. Korinth, C. Rheinert, G. Mehltretter, B. Schön, N. Schön, A. Starflinger, E. Englmann, G. Baytok, T. Laschinger, G. Ritscher, A. Gerth, D. Dechering, L. Eckardt, M. Kuhlmann, N. Proskynitopoulos, J. Brunn, K. Foth, C. Axthelm, H. Hohensee, K. Eberhard, S. Turbanisch, N. Hassler, A. Koestler, G. Stenzel, D. Kschiwan, M. Schwefer, S. Neiner, S. Hettwer, M. Haeussler-Schuchardt, R. Degenhardt, S. Sennhenn, M. Brendel, A. Stoehr, W. Widjaja, S. Loehndorf, A. Logemann, J. Hoskamp, J. Grundt, M. Block, R. Ulrych, A. Reithmeier, V. Panagopoulos, C. Martignani, D. Bernucci, E. Fantecchi, I. Diemberger, M. Ziacchi, M. Biffi, P. Cimaglia, J. Frisoni, I. Giannini, S. Boni, S. Fumagalli, S. Pupo, A. Di Chiara, P. Mirone, F. Pesce, C. Zoccali, V.L. Malavasi, A. Mussagaliyeva, B. Ahyt, Z. Salihova, K. Koshum-Bayeva, A. Kerimkulova, A. Bairamukova, B. Lurina, R. Zuzans, S. Jegere, I. Mintale, K. Kupics, K. Jubele, O. Kalejs, K. Vanhear, M. Burg, M. Cachia, E. Abela, S. Warwicker, T. Tabone, R. Xuereb, D. Asanovic, D. Drakalovic, M. Vukmirovic, N. Pavlovic, L. Music, N. Bulatovic, A. Boskovic, H. Uiterwaal, N. Bijsterveld, J. De Groot, J. Neefs, N. van den Berg, F. Piersma, A. Wilde, V. Hagens, J. Van Es, J. Van Opstal, B. Van Rennes, H. Verheij, W. Breukers, G. Tjeerdsma, R. Nijmeijer, D. Wegink, R. Binnema, S. Said, S. Philippens, W. van Doorn, T. Szili-Torok, R. Bhagwandien, P. Janse, A. Muskens, M. van Eck, R. Gevers, N. van der Ven, A. Duygun, B. Rahel, J. Meeder, A. Vold, C. Holst Hansen, I. Engset, B. Dyduch-Fejklowicz, E. Koba, M. Cichocka, A. Sokal, A. Kubicius, E. Pruchniewicz, A. Kowalik-Sztylc, W. Czapla, I. Mróz, M. Kozlowski, T. Pawlowski, M. Tendera, A. Winiarska-Filipek, A. Fidyk, A. Slowikowski, M. Haberka, M. Lachor-Broda, M. Biedron, Z. Gasior, M. Kołodziej, M. Janion, I. Gorczyca-Michta, B. Wozakowska-Kaplon, M. Stasiak, P. Jakubowski, T. Ciurus, J. Drozdz, M. Simiera, P. Zajac, T. Wcislo, P. Zycinski, J. Kasprzak, A. Olejnik, E. Harc-Dyl, J. Miarka, M. Pasieka, M. Ziemińska-Łuć, W. Bujak, A. Śliwiński, A. Grech, J. Morka, K. Petrykowska, M. Prasał, G. Hordyński, P. Feusette, P. Lipski, A. Wester, W. Streb, J. Romanek, P. Woźniak, M. Chlebuś, P. Szafarz, W. Stanik, M. Zakrzewski, J. Kaźmierczak, A. Przybylska, E. Skorek, H. Błaszczyk, M. Stępień, S. Szabowski, W. Krysiak, M. Szymańska, J. Karasiński, J. Blicharz, M. Skura, K. Hałas, L. Michalczyk, Z. Orski, K. Krzyżanowski, A. Skrobowski, L. Zieliński, M. Tomaszewska-Kiecana, M. Dłużniewski, M. Kiliszek, M. Peller, M. Budnik, P. Balsam, G. Opolski, A. Tymińska, K. Ozierański, A. Wancerz, A. Borowiec, E. Majos, R. Dabrowski, H. Szwed, A. Musialik-Lydka, A. Leopold-Jadczyk, E. Jedrzejczyk-Patej, M. Koziel, M. Mazurek, K. Krzemien-Wolska, P. Starosta, E. Nowalany-Kozielska, A. Orzechowska, M. Szpot, M. Staszel, S. Almeida, H. Pereira, L. Brandão Alves, R. Miranda, L. Ribeiro, F. Costa, F. Morgado, P. Carmo, P. Galvao Santos, R. Bernardo, P. Adragão, G. Ferreira da Silva, M. Peres, M. Alves, M. Leal, A. Cordeiro, P. Magalhães, P. Fontes, S. Leão, A. Delgado, A. Costa, B. Marmelo, B. Rodrigues, D. Moreira, J. Santos, L. Santos, A. Terchet, D. Darabantiu, S. Mercea, V. Turcin Halka, A. Pop Moldovan, A. Gabor, B. Doka, G. Catanescu, H. Rus, L. Oboroceanu, E. Bobescu, R. Popescu, A. Dan, A. Buzea, I. Daha, G. Dan, I. Neuhoff, M. Baluta, R. Ploesteanu, N. Dumitrache, M. Vintila, A. Daraban, C. Japie, E. Badila, H. Tewelde, M. Hostiuc, S. Frunza, E. Tintea, D. Bartos, A. Ciobanu, I. Popescu, N. Toma, C. Gherghinescu, D. Cretu, N. Patrascu, C. Stoicescu, C. Udroiu, G. Bicescu, V. Vintila, D. Vinereanu, M. Cinteza, R. Rimbas, M. Grecu, A. Cozma, F. Boros, M. Ille, O. Tica, R. Tor, A. Corina, A. Jeewooth, B. Maria, C. Georgiana, C. Natalia, D. Alin, D. Dinu-Andrei, M. Livia, R. Daniela, R. Larisa, S. Umaar, T. Tamara, M. Ioachim Popescu, D. Nistor, I. Sus, O. Coborosanu, N. Alina-Ramona, R. Dan, L. Petrescu, G. Ionescu, C. Vacarescu, E. Goanta, M. Mangea, A. Ionac, C. Mornos, D. Cozma, S. Pescariu, E. Solodovnicova, I. Soldatova, J. Shutova, L. Tjuleneva, T. Zubova, V. Uskov, D. Obukhov, G. Rusanova, N. Isakova, S. Odinsova, T. Arhipova, E. Kazakevich, O. Zavyalova, T. Novikova, I. Riabaia, S. Zhigalov, E. Drozdova, I. Luchkina, Y. Monogarova, D. Hegya, L. Rodionova, V. Nevzorova, O. Lusanova, A. Arandjelovic, D. Toncev, L. Vukmirovic, M. Radisavljevic, M. Milanov, N. Sekularac, M. Zdravkovic, S. Hinic, S. Dimkovic, T. Acimovic, J. Saric, S. Radovanovic, A. Kocijancic, B. Obrenovic-Kircanski, D. Kalimanovska Ostric, D. Simic, I. Jovanovic, I. Petrovic, M. Polovina, M. Vukicevic, M. Tomasevic, N. Mujovic, N. Radivojevic, O. Petrovic, S. Aleksandric, V. Kovacevic, Z. Mijatovic, B. Ivanovic, M. Tesic, A. Ristic, B. Vujisic-Tesic, M. Nedeljkovic, A. Karadzic, A. Uscumlic, M. Prodanovic, M. Zlatar, M. Asanin, B. Bisenic, V. Vasic, Z. Popovic, D. Djikic, M. Sipic, V. Peric, B. Dejanovic, N. Milosevic, S. Backovic, A. Stevanovic, A. Andric, B. Pencic, M. Pavlovic-Kleut, V. Celic, M. Pavlovic, M. Petrovic, M. Vuleta, N. Petrovic, S. Simovic, Z. Savovic, S. Milanov, G. Davidovic, V. Iric-Cupic, D. Djordjevic, M. Damjanovic, S. Zdravkovic, V. Topic, D. Stanojevic, M. Randjelovic, R. Jankovic-Tomasevic, V. Atanaskovic, S. Antic, D. Simonovic, M. Stojanovic, S. Stojanovic, V. Mitic, V. Ilic, D. Petrovic, M. Deljanin Ilic, S. Ilic, V. Stoickov, S. Markovic, A. Mijatovic, D. Tanasic, G. Radakovic, J. Peranovic, N. Panic-Jelic, O. Vujadinovic, P. Pajic, S. Bekic, S. Kovacevic, A. García Fernandez, A. Perez Cabeza, M. Anguita, L. Tercedor Sanchez, E. Mau, J. Loayssa, M. Ayarra, M. Carpintero, I. Roldán Rabadan, M. Gil Ortega, A. Tello Montoliu, E. Orenes Piñero, S. Manzano Fernández, F. Marín, A. Romero Aniorte, A. Veliz Martínez, M. Quintana Giner, G. Ballesteros, M. Palacio, O. Alcalde, I. García-Bolao, V. Bertomeu Gonzalez, F. Otero-Raviña, J. García Seara, J. Gonzalez Juanatey, N. Dayal, P. Maziarski, P. Gentil-Baron, M. Koç, E. Onrat, I.E. Dural, K. Yilmaz, B. Özin, S. Tan Kurklu, Y. Atmaca, U. Canpolat, L. Tokgozoglu, A.K. Dolu, B. Demirtas, D. Sahin, O. Ozcan Celebi, G. Gagirci, U.O. Turk, H. Ari, N. Polat, N. Toprak, M. Sucu, O. Akin Serdar, A. Taha Alper, A. Kepez, Y. Yuksel, A. Uzunselvi, S. Yuksel, M. Sahin, O. Kayapinar, T. Ozcan, H. Kaya, M.B. Yilmaz, M. Kutlu, M. Demir, C. Gibbs, S. Kaminskiene, M. Bryce, A. Skinner, G. Belcher, J. Hunt, L. Stancombe, B. Holbrook, C. Peters, S. Tettersell, A. Shantsila, D. Lane, K. Senoo, M. Proietti, K. Russell, P. Domingos, S. Hussain, J. Partridge, R. Haynes, S. Bahadur, R. Brown, S. McMahon, J. McDonald, K. Balachandran, R. Singh, S. Garg, H. Desai, K. Davies, W. Goddard, G. Galasko, I. Rahman, Y. Chua, O. Payne, S. Preston, O. Brennan, L. Pedley, C. Whiteside, C. Dickinson, J. Brown, K. Jones, L. Benham, R. Brady, L. Buchanan, A. Ashton, H. Crowther, H. Fairlamb, S. Thornthwaite, C. Relph, A. McSkeane, U. Poultney, N. Kelsall, P. Rice, T. Wilson, M. Wrigley, R. Kaba, T. Patel, E. Young, J. Law, C. Runnett, H. Thomas, H. McKie, J. Fuller, S. Pick, A. Sharp, A. Hunt, K. Thorpe, C. Hardman, E. Cusack, L. Adams, M. Hough, S. Keenan, A. Bowring, J. Watts, J. Zaman, K. Goffin, H. Nutt, Y. Beerachee, J. Featherstone, C. Mills, J. Pearson, L. Stephenson, S. Grant, A. Wilson, C. Hawksworth, I. Alam, M. Robinson, S. Ryan, R. Egdell, E. Gibson, M. Holland, D. Leonard, B. Mishra, S. Ahmad, H. Randall, J. Hill, L. Reid, M. George, S. McKinley, L. Brockway, W. Milligan, J. Sobolewska, J. Muir, L. Tuckis, L. Winstanley, P. Jacob, S. Kaye, L. Morby, A. Jan, T. Sewell, C. Boos, B. Wadams, C. Cope, P. Jefferey, N. Andrews, A. Getty, A. Suttling, C. Turner, K. Hudson, R. Austin, S. Howe, R. Iqbal, N. Gandhi, K. Brophy, P. Mirza, E. Willard, S. Collins, N. Ndlovu, E. Subkovas, V. Karthikeyan, L. Waggett, A. Wood, A. Bolger, J. Stockport, L. Evans, E. Harman, J. Starling, L. Williams, V. Saul, M. Sinha, L. Bell, S. Tudgay, S. Kemp, L. Frost, T. Ingram, A. Loughlin, C. Adams, M. Adams, F. Hurford, C. Owen, C. Miller, D. Donaldson, H. Tivenan, H. Button, A. Nasser, O. Jhagra, B. Stidolph, C. Brown, C. Livingstone, M. Duffy, P. Madgwick, P. Roberts, E. Greenwood, L. Fletcher, M. Beveridge, S. Earles, D. McKenzie, D. Beacock, M. Dayer, M. Seddon, D. Greenwell, F. Luxton, F. Venn, H. Mills, J. Rewbury, K. James, K. Roberts, L. Tonks, D. Felmeden, W. Taggu, A. Summerhayes, D. Hughes, J. Sutton, L. Felmeden, M. Khan, E. Walker, L. Norris, L. O'Donohoe, A. Mozid, H. Dymond, H. Lloyd-Jones, G. Saunders, D. Simmons, D. Coles, D. Cotterill, S. Beech, S. Kidd, B. Wrigley, S. Petkar, A. Smallwood, R. Jones, E. Radford, S. Milgate, S. Metherell, V. Cottam, C. Buckley, A. Broadley, D. Wood, J. Allison, K. Rennie, L. Balian, L. Howard, L. Pippard, S. Board, and T. Pitt-Kerby
Subjects: Male, AF registry, Atrial fibrillation, Biomarkers, Death, Major adverse cardiovascular events, outcomes, Troponins, Troponin, Risk Factors, Atrial Fibrillation, Internal Medicine, Humans, Female, Prospective Studies, Registries, Aged
Abstract: BACKGROUND: Cardiac troponins (cTn) have been reported to be predictors for adverse outcomes in atrial fibrillation (AF), patients, but their actual use is still unclear.AIM: To assess the factors associated with cTn testing in routine practice and evaluate the association with outcomes.METHODS: Patients enrolled in the ESC-EHRA EORP-AF General Long-Term Registry were stratified into 3 groups according to cTn levels as (i) cTn not tested, (ii) cTn in range (≤99th percentile), (iii) cTn elevated (>99th percentile). The composite outcome of any thromboembolism /any acute coronary syndrome/cardiovascular (CV) death, defined as Major Adverse Cardiovascular Events (MACE) and all-cause death were the main endpoints.RESULTS: Among 10 445 AF patients (median age 71 years, 40.3% females) cTn were tested in 2834 (27.1%). cTn was elevated in 904/2834 (31.9%) and in-range in 1930/2834 (68.1%) patients. Female sex, in-hospital enrollment, first-detected AF, CV risk factors, history of coronary artery disease, and atypical AF symptoms were independently associated with cTn testing. Elevated cTn were independently associated with a higher risk for MACE (Model 1, hazard ratio [HR] 1.74, 95% confidence interval [CI] 1.40-2.16, Model 2, HR 1.62, 95% CI 1.28-2.05; Model 3 HR 1.76, 95% CI 1.37-2.26) and all-cause death (Model 1, HR 1.45, 95% CI 1.21-1.74; Model 2, HR 1.36, 95% CI 1.12-1.66; Model 3, HR 1.38, 95% CI 1.12-1.71).CONCLUSIONS: Elevated cTn levels were associated with an increased risk of all-cause mortality and adverse CV events. Clinical factors that might enhance the need to rule out CAD were associated with cTn testing.
Published: 2022
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5. The conflict between Rights of Nature and mining in Ecuador: Implications of the Los Cedros Cloud Forest case for biodiversity conservation

Author: M. R. Peck, M. Desselas, S. Bonilla‐Bedoya, G. Redín, and J. Durango‐Cordero
Subjects: biodiversity, ecosystems, Ecuador, forests, rights of nature, Human ecology. Anthropogeography, GF1-900, Ecology, QH540-549.5
Abstract: Abstract Global emergence of Rights of Nature (RoN) has gained momentum since Ecuador became the first country to constitutionally recognize it in 2008. The shift from perceiving nature as an object, to granting it legal subjecthood, can revolutionize protection of ecological systems. In 2021, Ecuador's Constitutional Court issued a landmark ruling, halting mining in the Los Cedros Protected Forest. Three pillars form the basis for legal protection of Los Cedros: (i) the right to timely, Free Prior Informed Environmental Consultation, (ii) application of the Precautionary Principle in risk to RoN, and (iii) the Right to Water. We analyse the Court ruling to identify legal frameworks applied then map and rank mining risk to other protected forests, Indigenous territories, unprotected native ecosystems, biodiversity and areas of water resource conflict to determine potential scale of conflict between mining and RoN. 7813 mining concessions of 22,812km2 overlay 9.2% of Ecuadorian mainland, 2323 concessions (29.7%) overlap 16,081km2 of protected forest (4781 km2, 20%), Indigenous territory (6473 km2, 8%) and native vegetation outside protected areas and Indigenous territories (13,390 km2, 9%). With 80% of their protected forests at risk from large‐scale mining, the most impacted Indigenous communities are the Shuar. Synthesis and applications: The Los Cedros legal case in Ecuador sets a precedent for using RoN to challenge mining in 4781 km2 of similar Protected Forest, with potential to protect an additional 16,081 km2 of Indigenous lands and biologically important ecosystems. However, lack of biological data for these areas will necessitate extensive data collection, possibly through community‐empowering citizen science. Our study emphasizes the urgent need to integrate indigenous and traditional ecological knowledge (ITEK), law and ecology. We propose a new transdisciplinary field of ‘ecological forensics’ to support nature protection within the RoN framework. Our research also identifies areas where RoN could effectively protect nature and that are likely to be of high investment risk for the mining industry. The final recommendation is to reconsider mining concessions in Ecuador, especially in ecologically sensitive areas, Indigenous territories, high biodiversity areas, and regions with water resource conflicts, to maintain ecological integrity and social harmony. Read the free Plain Language Summary for this article on the Journal blog.
Published: 2024
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6. Contribution du break up time au diagnostic et à la prise en charge du syndrome sec oculaire en milieu tropical : à propos de 234 yeux à Abidjan

Author: K. Gbe, G.Y. Ouffoue, A. Ouattara, S. Boni, A. Fanny, R.P. Agbohoun, W.J. Cheucheu, E Gombe, L. Ouonnebo, L.J.K. Kouassi, and A J Konan
Subjects: Gynecology, Ophthalmology, medicine.medical_specialty, business.industry, Break up time, medicine, business, Ocular surface
Abstract: Resume Introduction La secheresse oculaire, motif frequent de consultation peut etre evaluee cliniquement par la mesure du temps de rupture du film lacrymal ou break up time (BUT). Il existe souvent une discordance entre signes fonctionnels evocateurs de secheresse oculaire et mesures cliniques du BUT. Nous avons donc voulu evaluer la fiabilite du BUT dans le diagnostic et la prise en charge du syndrome sec chez le noir Africain. Materiel et methode Les auteurs ont realise une etude prospective de 6 mois sur des patients adultes melanodermes qui ont presente des signes fonctionnels evocateurs de secheresse oculaire selon un questionnaire a 7 items. Le BUT est mesure apres instillation d’une goutte de fluoresceine a l’aide d’un chronometre entre le dernier clignement palpebral et la premiere rupture du film lacrymal corneen. Les patients ayant un syndrome sec fonctionnel et un temps de rupture du film lacrymal inferieur a 10 secondes ont ete retenus comme souffrant d’un syndrome sec et ont ete designes concordants. Les discordants etaient ceux dont le temps de mesure du BUT etait superieur a 10 secondes bien qu’ayant repondu positivement au questionnaire. Resultats Notre etude a porte sur 234 patients et la moyenne d’âge etait de 49,1 ans. Le sex-ratio de la population d’etude etait de 0,68 et on notait une predominance de temps de rupture compris entre 5 et 10 secondes soit 42,3 % des cas. Le syndrome sec fonctionnel a ete confirme cliniquement par un BUT inferieur a 10 secondes chez 149 personnes portant la fiabilite du BUT comme outil de diagnostic clinique apres une symptomatologie fonctionnelle evocatrice a 63,7 %. Parmi ces concordants, les femmes etaient plus sujettes a presenter une secheresse oculaire par rapport aux hommes avec une difference significative (p = 0,0005). L’âge superieur a 50 ans et l’usage de l’ordinateur etaient des facteurs de risque de la secheresse oculaire (p Discussion La secheresse oculaire est une affection multifactorielle des larmes et de la surface oculaire beaucoup plus frequente chez le sujet feminin, de plus de 50 ans et utilisant frequemment l’ordinateur. La fiabilite du BUT avoisinant les 65 % nous autorise a le preconiser en pratique clinique. Conclusion Le temps de rupture du film lacrymal ou BUT est un test clinique fiable de realisation simple qui peut etre utilise pour confirmer le diagnostic de secheresse oculaire.
Published: 2019
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7. SPATIAL STRUCTURE OF ECTOMYCORRHIZAL TREES IN WOODED SAVANNAS OF GUINEO-SUDANIAN ECOZONE IN WEST AFRICA

Author: J. E. I. Codjia, G. A. Laourou, S. Boni, Nourou S. Yorou, I. K. Tchan, L. H. Aignon, S. A. Badou, and R. D. Houdanon
Subjects: Vegetation types, Geography, Spatial structure, Ecology, Mycorrhizal fungi, Ecozone, Forestry, Spatial distribution, Ectosymbiosis, West africa
Published: 2019
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8. Region of interest localization, tissue storage time, and antibody binding density—a technical note on the GeoMx® Digital Spatial Profiler

Author: S. Böning, F. Schneider, A.-K. Huber, D. Langhoff, H. Lin, A. Kaczorowski, A. Stenzinger, M. Hohenfellner, S. Duensing, and A. Duensing
Subjects: digital spatial profiling, spatial biology, tumor heterogeneity, prostate cancer, renal cell carcinoma, immuno-oncology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: Spatial biology is an emerging concept to interrogate tumor heterogeneity. The NanoString GeoMx® Digital Spatial Profiling (DSP) platform has become increasingly available. It combines high-plex analysis of protein or messenger RNA expression using barcoded antibodies or oligonucleotide probes with investigator-driven selection of regions of interest. Cell populations, e.g. immune cells, can be selectively analyzed via segmentation. A key advantage is the use of archived formalin-fixed, paraffin-embedded tissue, however, begging the question whether and to what extent tissue fixation and storage time affect the results. Materials and methods: Antibody binding density (ABD), i.e. the number of barcodes/μm2, is a key quality control measure for DSP spatial proteomics. To assess whether regional differences in tissue fixation have an influence on ABD, we compared 652 regions of interest selected from tumor center and periphery of 49 prostate cancer and 25 renal cell carcinoma (RCC) specimens. Moreover, the effect of tissue storage time on ABD was examined. Finally, we tested whether regional differences have an influence on ABD of segmented CD45+ or CD8+ cells. Results: No significant differences in ABD between tumor center and periphery were found in prostate cancer or RCC. However, ABD was significantly higher in recent specimens (≤5 years) when compared with those that were older (>5 years; P = 0.027). There was a trend towards higher ABD in the tumor periphery of RCC specimens after segmentation for immune cells, albeit without reaching statistical significance. Conclusions: The NanoString GeoMx® DSP platform delivers robust data to interrogate tumor heterogeneity, but tissue storage time should be considered when interpreting the results.
Published: 2024
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9. Motor synergies: Evidence for a novel motor signature in autism spectrum disorder

Author: S. Boni, Luciano Fadiga, C. Veronesi, G. Nazzaro, Maddalena Marini, Marco Emanuele, G. Polletta, Alessandro D'Ausilio, Emanuele, M., Nazzaro, G., Marini, M., Veronesi, C., Boni, S., Polletta, G., D'Ausilio, A., and Fadiga, L.
Subjects: Linguistics and Language, Kinematics, Autism Spectrum Disorder, Cognitive Neuroscience, Experimental and Cognitive Psychology, Social behaviour, Language and Linguistics, NO, Typically developing, Motor synergies, Neurodevelopmental disorder, Machine learning, Developmental and Educational Psychology, medicine, Motor synergie, Humans, Set (psychology), Child, Social Behavior, Autism spectrum disorder, Early diagnosis, Neurodevelopmental disorders, Hand Strength, Mechanism (biology), Communication, Motor control, Early diagnosi, medicine.disease, Kinematic, Biomechanical Phenomena, Coding system, Psychology, Cognitive psychology, Human
Abstract: In autism spectrum disorder (ASD), socio-communicative impairments and stereotypical behaviours are paralleled by sensorimotor deficits. Individuals with ASD show an altered selection of motor parameters, resulting in clumsy and fragmented actions. Here, we investigated inter-joint coordination and motor synergies as a potential substrate of motor control problems in ASD. Synergies enable co-controlling redundant motor degrees of freedom (DoF, e.g. joint angles, muscles) by mapping behavioural goals into a flexible and low-dimensional set of variables. This mechanism simplifies motor control and helps to find unambiguous solutions for motor tasks. In a reaching-grasping paradigm, children with ASD showed reduced coupling between DoF, which correlated with socio-communicative symptoms severity. Impaired synergies may help to frame well-established motor problems in ASD, including impaired motor sequencing and abnormal trial-to-trial motor variability. On the other hand, synergies also provide an effective and compact coding system of observed actions. Impaired synergies may thus jeopardize motor interaction by initiating bottom-up cascade effects, leading to pervasive impairments of social behaviour. Finally, we trained an automatic classification algorithm to distinguish between ASD and typically developing (TD) participants based on reaching-grasping kinematics. Classification accuracy reached up to 0.947. This result corroborates and expands previous accounts claiming that motor-based early recognition is feasible and effective in ASD.
Published: 2021

10. Trabéculoplastie sélective chez le mélanoderme africain

Author: Y G Ouffoue, L.J.K. Kouassi, O A S Ouattara, R. Bérété-Coulibaly, K. Gbe, S. Boni, F. Coulibaly, A J Konan, A. Fanny, and A. Ouattara
Subjects: 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, 030221 ophthalmology & optometry
Abstract: Resume Introduction Le traitement du glaucome primitif a angle ouvert (GPAO) est preferentiellement medical. Cependant en cas d’echec ou d’insuffisance de celui ci, des traitements alternatifs ou complementaires peuvent etre envisages. La trabeculoplastie selective dans cette approche est un traitement physique en plein essor et les avantages qui lui sont reconnus ont ete tres peu etudies chez le sujet melanoderme africain. L’objectif de cette etude etait d’evaluer l’efficacite de la trabeculoplastie selective sur la baisse de la pression intraoculaire (PIO) chez le sujet melanoderme africain atteint de GPAO. Methode Nous avons realise une etude retrospective chez des patients melanodermes traites par laser selectif entre mars 2010 et mars 2011. Tous les patients presentaient un GPAO avec trabeculum accessible sur 360°. Le protocole therapeutique a consiste en un traitement sur 360° en 2 seances (180°/seance) a 15 jours d’intervalle. Le succes etait defini par une baisse de la PIO initiale ≥ 3 mm Hg sans traitement supplementaire. Resultats Nous avons retenu 44 patients correspondant a 82 yeux. L’âge moyen des patients etait de 55,94 ± 11,66 ans avec des extremes de 19 ans et 76 ans. La pression intraoculaire moyenne avant le traitement au laser (PIO initiale) etait de 18,43 ± 4,18 mm Hg. Apres traitement au laser, la reduction pressionnelle moyenne etait de (i) 3,81 mm Hg (20,67 %) a 15 jours ; (ii) 4,08 mm Hg (22,14 %) a 1 mois ; (iii) 4,45 mm Hg (24,14 %) a 3 mois ; (iv) 4,95 mm Hg (26,86 %) a 6 mois. Le taux de succes apres traitement au laser etait de 67,60 % a 15 jours, 83,78 % a 1 mois, 72,09 % a 3 mois et 80,43 % a 6 mois. Conclusion La trabeculoplastie selective est efficace chez le melanoderme africain. Son efficacite est comparable a celle d’un inhibiteur de l’anhydrase carbonique voire une prostaglandine. Elle pourrait etre une alternative complementaire ou substitutive du traitement du GPAO chez le melanoderme africain.
Published: 2019
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11. Infection invasive à champignon filamenteux pseudotumorale du sinus maxillaire à Abidjan

Author: C. Assouan, A. Tanon, E. Anzouan-Kacou, E. Konan, D. N’guessan, A. Salami, and S. Boni
Subjects: 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, 030221 ophthalmology & optometry, 030206 dentistry
Abstract: Resume Introduction Les infections invasives a champignon filamenteux du sinus maxillaire sont des affections rares et graves generalement favorisees par l’immunodepression. Nous rapportons une observation rare d’infection fongique invasive pseudotumorale du sinus maxillaire chez un malade immunocompetent. Observation Un patient âge de 32 ans a consulte pour tumefaction genienne et temporale gauche associee a une exophtalmie et un chemosis evoluant depuis 18 mois. Le scanner objectivait un comblement du sinus maxillaire gauche et de la cavite orbitaire homolaterale ainsi que des muscles environnants. L’examen histologique de la piece operatoire a mis en evidence une infection invasive a champignon filamenteux du sinus maxillaire gauche. Le traitement antifongique de reference, a savoir le voriconazole, n’a pu etre administre du fait de l’indisponibilite du produit. Cependant, le patient a recu de l’itraconazole en raison de 200 mg toutes les 12 h pendant cinq semaines. L’evolution s’est averee decevante avec recidive et sequelles importantes, a type d’affaissement de l’hemiface droite, de limitation severe de l’ouverture buccale et de perte fonctionnelle de l’œil droit. Conclusion Les infections invasives a champignons filamenteux du sinus maxillaire et de l’orbite sont exceptionnelles chez le sujet immunocompetent. La guerison repose sur la precocite du diagnostic et a l’administration de l’antifongique de reference au risque de recidive.
Published: 2017
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12. Evaluation of particle size and feed form on performance, carcass characteristics, nutrient digestibility, and gastrointestinal tract development of broilers at 39 d of age

Author: M.S. Rueda, S. Bonilla, C. de Souza, J.D. Starkey, C.W. Starkey, L. Mejia, and W.J. Pacheco
Subjects: breast myopathy, GI tract, gizzard, reverse peristalsis, Animal culture, SF1-1100
Abstract: ABSTRACT: The objective of this study was to evaluate combined effects of corn particle size and feed form on performance, carcass characteristics, nutrient digestibility, and gastrointestinal tract development of broilers from 1 to 39 d of age. A total of 1,800 days old, male Cobb 500 broilers were randomly assigned to 9 dietary treatments with 8 replicate pens (25 birds/pen). The experiment consisted of a factorial arrangement of 3 corn particle sizes (750, 1,150, and 1,550 μm) and 3 feed forms (mash, 3- and 4-mm pellets) provided from 1 to 39 d. Titanium dioxide (TiO2) was added as an indigestible marker (0.5%) during the finisher phase (27–39 d) to determine nutrient digestibility. Feed intake (FI), body weight (BW), and feed conversion ratio (FCR) were determined at 17, 27, and 39 d of age, with FCR adjusted for mortality. On d 40, 10 birds/pen were randomly selected and processed for meat yield determination. Data were analyzed as a 3×3 factorial (particle size x feed form) arrangement of treatments. Broilers fed 3- and 4-mm pellets had increased (P < 0.05) BW, FI, and lower FCR than broilers fed mash diets at 39 d of age. At 39 d of age, broilers fed diets with 750 µm corn particle size had heavier (P < 0.05) BW and increased FI than broilers fed diets with corn particle sizes of 1,150 and 1,550 µm. At 39 d of age FCR was unaffected by corn particle size. Heavier (P < 0.05) carcass and breast weights were observed for broilers fed 3-mm pellets. Broilers fed diets with corn particle size of 750 µm had heavier (P < 0.05) carcass and breast weight than broilers fed diets with 1,550 µm. Digestibility of nutrients was higher (P < 0.05) in pelleted diets, particularly when corn particle size was increased from 750 to 1,550 µm. Breast myopathies such as wooden breast (WB) and spaghetti meat (SM), were greater (P < 0.05) in broilers fed 3-mm pellets compared to mash diets. In conclusion, broilers fed 3- and 4-mm pelleted diets had greater nutrient digestibility and improved broiler performance compared to broilers fed mash diets.
Published: 2024
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13. Assessment of pre-harvest aflatoxin and fumonisin contamination of maize in Babati District, Tanzania

Author: C. Nyangi, S. Boni, Michael Sulyok, Fen D. Beed, J.K. Mugula, Mateete A. Bekunda, E. Koyano, and George S. Mahuku
Subjects: 0106 biological sciences, Aflatoxin, business.industry, Sowing, Staple food, 010501 environmental sciences, Biology, Food safety, aflatoxins, fumonisins, at-harvest, maize, Tanzania, mycotoxins, food safety, farming practices, staple food, 01 natural sciences, Toxicology, Tillage, chemistry.chemical_compound, chemistry, Agronomy, Agriculture, Fumonisin, business, Mycotoxin, 010606 plant biology & botany, 0105 earth and related environmental sciences
Abstract: A survey was conducted in 2013 to establish total aflatoxin and total fumonisin in maize, as well as farmers’ practices relating to maize cultivation and awareness of mycotoxins, in three villages of Babati District, northern Tanzania. Quantification of total aflatoxin and fumonisin was done using enzyme-linked immunosorbent assay (Reveal AccuScan ® Neogen, USA) and the results were confirmed using Liquid Chromatography Tandem Mass Spectrometer. The mean aflatoxin was 2.94 μg/kg and all samples (n=440) were within the East African Community (EAC) standard of 10 μg/kg for total aflatoxin, but the mean fumonisin was 5.15 mg/kg, more than double the EAC standard of 2 mg/kg, and 35% of samples exceeded this standard. Maize samples obtained from farmers in the village in the mid altitude, dry zone had significantly higher mean aflatoxin (3.32 μg/kg) and significantly lower mean fumonisin (3.17 mg/kg) than maize from the other two villages (in the high and mid altitude, high rainfall zones). Most farmers (n=442) were male (72%), educated to primary school level (77%) and aware of mycotoxins (62%). As well as participating in a development program, Africa Research in Sustainable Intensification for the Next Generation, most (86%) farmers had experience of working with other development programs. All farmers used flat planting, most used improved seeds (98%), ox ploughing (78%), insecticides (78%) and early planting (36%). Practices associated with mycotoxins were planting time, tillage methods, previous season planted crops, and use of insecticides. Awareness of mycotoxins and climatic conditions were also associated with mycotoxin prevalence. In conclusion, good practices are associated with acceptable aflatoxin levels and should be continued. However, the high level of fumonisins warrants further investigation. Keywords: aflatoxins, fumonisins, at-harvest, maize, Tanzania, mycotoxins, food safety, farming practices, staple food
Published: 2016
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14. Aflatoxins and fumonisin contamination of marketed maize, maize bran and maize used as animal feed in Northern Tanzania

Author: Michael Sulyok, S. Boni, C. Nyangi, E. Koyano, Fen D. Beed, and J.K. Mugula
Subjects: Aflatoxin, Bran, Animal feed, 010401 analytical chemistry, Tanzania, aflatoxins, fumonisins, food safety, maize, market, processors, animal feed, 04 agricultural and veterinary sciences, Biology, Contamination, 040401 food science, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, chemistry, Marketed products, Fumonisin, Food science
Abstract: The objective of this study was to investigate the occurrence of total aflatoxin and total fumonisin in maize and maize-based products in Babati, northern Tanzania. A total of 160 samples were collected in 2013-14. Quantification for total aflatoxin and fumonisin was done using enzyme-linked immunosorbent assay (Reveal AccuScan® Neogen, USA) and the results were confirmed using Liquid Chromatography Tandem Mass Spectrometer. Aflatoxin was detected in 32% of maize samples (mean 3.4 ± 0.3 μg/kg; range 2.1–16.2 μg/kg) and fumonisin in 39% of samples (mean 5.6 ± 1.40 mg/kg; range 0.4–62.0 mg/kg). Among marketed products, maize bran (used for animal feed) was the most contaminated (2.4 μg/kg aflatoxin and 1 mg/kg fumonisin), followed by whole maize in market stalls (1.9 μg/kg aflatoxin and 0.4 mg/kg fumonisin) and then maize flour (1.4 μg/kg aflatoxin and 0.3 mg/kg fumonisin). Un-marketed maize sorted out by farmers as “bad” and intended for animal feeding was the most contaminated (overall mean aflatoxin and fumonisin levels of 1.7 μg/kg and 7.4 mg/kg, respectively). The results indicate that levels of aflatoxin and fumonisin contamination in marketed maize were within tolerable limits. Keywords: Tanzania, aflatoxins, fumonisins, food safety, maize, market, processors, animal feed
Published: 2016
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15. Results of urogenital fistulas repair using caravan approach in Côte d’Ivoire

Author: Eric Bohoussou, S. Boni, K Manzan, Y Djanhan, G Gnanazan, L.E. Djanhan, and B Kouamé
Subjects: medicine.medical_specialty, business.industry, Genitourinary system, Fistula, Cote d ivoire, Retrospective cohort study, medicine.disease, Surgery, medicine.anatomical_structure, Epidemiology, Vagina, medicine, Etiology, Childbirth, business
Abstract: Aims: To report the experience of surgical caravans for urogenital fistulas care.Methods: It was a retrospective study covering the period from January 1st 2014 to December 31st 2014 and which took place on 7 sites of fistula care. The epidemiological, anatomic, clinical, therapeutic and evolutionary aspects were studied. Recruitment was made by radio announcements and word of mouth approaches. Treatment was free of charge for patients.Results: During 14 caravans 346 patients were operated. Their mean age was 33.11 years (12 - 70 years). Most of these patients were without remunerative activities (80%) and without education (63.3%). They had been living with fistula for 6.08 years on average (0 to 42). Obstetrical etiology was predominant (87.9%), the otherswere iatrogenic and traumatic. According to the Kees Waaldijk classification, fistulas were distributed as follows: type I (67.4%), type II Aa (12.7%), type II Ab (8.4%) and type III (11.5%). The most common surgical approach was the transvaginal route (82.1%). The vesicovaginal splitting with separated suture of the bladder and the vagina was the basic technique (94.7%). The therapeutic results were judged after a follow-up of 1 month and 3 months. Lost to follow-up within that period was 23% i.e. 80 patients in month one and 70% (245 patients) at month three. The success rates evaluated in patients reviewed at month one and at month 3 were respectively 70% and 64%.Conclusions: Caravan approach to recruit patients with fistula was feasible using local advertisements mans. Patients have been living with fistula for long time. Follow-up was difficult at Month 3.Keywords: dystocic childbirth, obstetrics, surgery, urogenital fistulas
Published: 2018
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16. Le esperienze abitative dei trentenni a Milano al tempo dell'esodo

Author: Eugenia Montagnini and Alice S. Boni
Subjects: Urban Studies, Visual Arts and Performing Arts, Geography, Planning and Development
Abstract: L’articolo presenta alcuni risultati di una ricerca avviata nel 2013 in occasione del Rapporto sulla citta di Milano dedicato ai trentenni e proseguita autonomamente nel 2014 dalle due autrici. La ricerca, condotta attraverso due sondaggi online, interviste a testimoni privilegiati e tre focus group, e stata tesa a sondare le esperienze abitative dei trentenni secondo una duplice accezione: abitare la casa e abitare la citta. Le testimonianze raccolte, pur non essendo rappresentative dell’universo dei trentenni, sono state utili per indagare da vicino la condizione abitativa di questa fascia di popolazione e le loro aspirazioni. Nella scelta del dove e del come abitare, in relazione alle possibilita offerte dal contesto, sono state rintracciate esperienze sociali e spaziali che interrogano temi quali l’attitudine verso forme di condivisione e la qualita dell’abitare
Published: 2016
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17. Central parks as air quality oases in the tropical Andean city of Quito

Author: R. Zalakeviciute, S. Bonilla Bedoya, D. Mejia Coronel, M. Bastidas, A. Buenano, and A. Diaz-Marquez
Subjects: Air pollution, PM2.5, Urban parks, City planning, Terrain, Environmental pollution, TD172-193.5, Meteorology. Climatology, QC851-999
Abstract: Urban ecosystem is an intricate agglomeration of human, fauna and flora populations coexisting in natural and artificial environments. As a city develops and expands over time; it may become unbalanced, affecting the quality of ecosystem and urban services and leading to environmental and health problems. Fine particulate matter (particulate matter with aerodynamic diameter ≤2.5 μm - PM2.5) is the air pollutant posing the greatest risk to human health. Quito, the capital city of Ecuador, exhibits a high occurrence of exposure to unhealthy levels of PM2.5 due to a combination of natural and social variables. This study focused on three central parks of this high elevation city, investigating the spatial distribution of PM2.5 concentrations. The particle pollution was then modeled using Normalized Difference Vegetation Index (NDVI). Hazardous instantaneous levels of PM2.5 were consistently found on the edges of the parks along busy avenues, which are also the most frequented areas. This raises concerns about both short- and long-term exposures to toxic traffic pollution in recreational areas within urban dwellings in the global south. The NDVI model successfully predicted the spatial concentrations of PM2.5 in a smaller urban park, suggesting its potential application in other cities. However, further research is required to validate its effectiveness.
Published: 2024
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18. Late AQP4-IgG seroconversion and shrinking of brainstem MRI lesions in a patient with overlapping CIS/NMOSD

Author: C. Serrati, S. Boni, A. Mannironi, Stefano Delucchi, Elisa Giorli, Alessandro Beronio, Diego Franciotta, Luana Benedetti, and C. Amodeo
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Neurology, Neuromyelitis optica, medicine.diagnostic_test, business.industry, Multiple sclerosis, Magnetic resonance imaging, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Aquaporin 4, Medicine, Neurology (clinical), Brainstem, Seroconversion, business, 030217 neurology & neurosurgery, Neuroradiology
Published: 2016
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19. Pulsed laser ablation synthesis of Cu-based and Ni-based nanostructured electrodes for highly active alkaline oxygen and hydrogen evolution reactions

Author: V. Iacono, C. Lo Pò, S. Scalese, S. Boninelli, G. G. Condorelli, M. G. Grimaldi, and F. Ruffino
Subjects: Biotechnology, TP248.13-248.65, Physics, QC1-999
Abstract: In the field of sustainability, hydrogen (H2) is considered a clean fuel and a renewable energy source with no pollutant emissions. The production of H2 by water electrolysis is well-known among the scientific community. Still, alkaline electrolysis represents a challenging process and requires expensive materials have to be avoided in order to lower the impact of H2 production. This work deals with the production of copper (Cu) and nickel (Ni) nanoparticles (NPs) as catalysts for alkaline water splitting reactions. These NPs are synthesized using the pulsed laser ablation in liquid involving the ablation of Cu and Ni targets in methanol and ethanol. The morphological, structural, and compositional properties of the obtained NPs are studied. Then, a low amount of NPs-based catalyst (∼1μg/cm2) was loaded onto a nickel foam substrate and tested for both alkaline Hydrogen Evolution Reaction (HER) and Oxygen Evolution Reaction (OER). The best performance at 10 mA cm−2, in terms of overpotential (η), for OER was shown by Ni NPs, η = 327 mV, while for the HER, Cu NPs reached η = 211 mV at 10 mA cm−2 in aqueous 1M KOH. The ultra-low amount of the catalyst material makes these electrodes challenging in terms of mass activity [up to 14 A/mg at 10 mA cm−2] compared to the state of the art. In addition, the correlation between overpotential and the availability of electrons at the surface of the catalyst for H2 production was studied by using Mott–Schottky analysis.
Published: 2023
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20. [When pterygium leads to blindness!!!]

Author: Y G, Ouffoue, S, Boni, K L J, Kouassi, A J, Konan, O A S, Ouattara, N J A, Cheucheu, V, Ilupeju, E, Gombe, and A, Fanny
Subjects: Male, Vision Disorders, Humans, Blindness, Pterygium, Conjunctiva
Published: 2017

21. [Contribution of break up time in the diagnosis and the treatment of dry eye syndrome in tropic area: about 234 patients in Abidjan]

Author: G Y, Ouffoue, S, Boni, A O, Ouattara, K, Gbe, L J K, Kouassi, A J, Konan, E, Gombe, L, Ouonnebo, R P, Agbohoun, A, Fanny, and W J, Cheucheu
Subjects: Adult, Aged, 80 and over, Male, Tropical Climate, Time Factors, Blinking, Lacrimal Apparatus, Diagnostic Techniques, Ophthalmological, Middle Aged, Young Adult, Cote d'Ivoire, Tears, Humans, Dry Eye Syndromes, Female, Aged
Abstract: Dry eye disease (DED) can be evaluated clinically by the tear film break up time (BUT). There is a discrepancy between symptoms in relationship with dry eye disease and objectives measures of BUT. So we tried to evaluate the reliability of BUT in the diagnosis and treatment of this disease in black African people.We carried out a prospective study of 6 months where melanoderms adults presenting subjective symptoms of dry eye disease according a questionnaire of 7 items were included. Then the measure of BUT is performed after ocular instillation of fluorescein eyedrop. This measured is done by recording the time elapsed from the last complete palpebral blink to the appearance of the first dry spot. Patients with subjective symptoms and time of BUT lower than 10seconds were called concordants (suffering really of DED). The discrepant group was represented by a BUT upper than 10seconds despite the fact that these patients answered positively to the questionnaire.This survey included 234 patients and the average age was 49.1 years. Sex-ratio was 0.68 and we noticed predominance of BUT between 5 and 10seconds in 42.3% of cases. Subjective symptoms were strengthened clinically by a BUT lower to 10seconds in 149 patients. Therefore, the reliability of BUT as clinic tool for the diagnosis after symptoms in relationship with DED was 63.7%. In the group of concordants, women were more likely than men to experience symptoms of DED (P=0.0005). Age upper than 50 years and computer usage were risk factors of DED (P0.01).Dry eye disease is a multifactorial affection of tear and ocular surface frequently seen in female and people using computer and older than 50. The reliability of BUT near to 65% is a reason to perform this test in our daily practice.Tear BUT is a reliable clinical test which must be performed systematically to assess the diagnosis of DED in black African people.
Published: 2017

22. [Selective laser trabeculoplasty in African blacks]

Author: O A S, Ouattara, F, Coulibaly, Y G, Ouffoué, A, Ouattara, A J, Konan, L J, Kouassi, R, Bérété-Coulibaly, S, Boni, K, Gbé, and A, Fanny
Subjects: Adult, Male, Young Adult, Treatment Outcome, Black People, Humans, Female, Trabeculectomy, Laser Therapy, Middle Aged, Glaucoma, Open-Angle, Aged, Retrospective Studies
Abstract: The treatment of primary open angle glaucoma (POAG) is preferably medical. However, when medical therapy fails, alternative or complementary treatments may be considered. In this regard, selective laser trabeculoplasty is a widely popular procedural treatment whose accepted benefits have been very little studied in African blacks. The objective of this study was to assess the efficacy of selective laser trabeculoplasty on the reduction of intraocular pressure (IOP) in African blacks with POAG.We conducted a retrospective study of black patients treated with selective laser trabeculoplasty between March 2010 and March 2011. All patients had POAG with trabecular meshwork accessible over 360°. The treatment protocol consisted of a 360°treatment in two sessions (180°/session) 15 days apart. Success was defined as decrease from the initial IOP≥3mm Hg without additional medications.We included 44 patients, corresponding to 82 eyes. The mean age of the patients was 55.94±11.66 years with extremes of 19 years and 76 years. The mean intraocular pressure before laser treatment (initial IOP) was 18.43±4.81mm Hg. After laser treatment, the mean pressure reduction was (i) 3.81mm Hg (20.67%) at 15 days ; (ii) 4.08mm Hg (22.14%) at 1 month; (iii) 4.45mm Hg (24.14%) at 3 months; and (iv) 4.95mm Hg (26.86%) at 6 months. The success rate after laser treatment was 67.60% at 15 days, 83.78% at 1 month, 72.09% at 3 months and 80.43% at 6 months.Selective laser trabeculoplasty is effective in African blacks. Its efficacy is comparable to that of a carbonic anhydrase inhibitor or even a prostaglandin. It could be a complementary or substitutive alternative to POAG medications in African blacks.
Published: 2017

23. Indications et efficacité des injections intravitréennes de bévacizumab chez le mélanoderme à Abidjan

Author: G.Y. Ouffoue, T C Sowagnon, A. Ouattara, E Gombe, A. Fanny, L.J.K. Kouassi, A J Konan, N W Cheucheu, and S. Boni
Subjects: Anti vegf, Ophthalmology, Text mining, business.industry, Medicine, Pharmacology, business
Published: 2019
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24. Quantitation of multiple mycotoxins and cyanogenic glucosides in cassava samples from Tanzania and Rwanda by an LC-MS/MS-based multi-toxin method

Author: S. Boni, Fen D. Beed, Rudolf Krska, A Mukunzi, Michael Sulyok, and Adebayo Abass
Subjects: Manihot, Health, Toxicology and Mutagenesis, Alternariol, Food Contamination, Toxicology, Tanzania, Matrix (chemical analysis), chemistry.chemical_compound, Glucosides, Tandem Mass Spectrometry, Nitriles, Tenuazonic acid, media_common.cataloged_instance, European union, Mycotoxin, Zearalenone, Toxins, Biological, media_common, Chromatography, Chemistry, Rwanda, Public Health, Environmental and Occupational Health, Brevianamide F, Reproducibility of Results, General Chemistry, General Medicine, Mycotoxins, Beauvericin, Food Microbiology, Chromatography, Liquid, Food Science
Abstract: A multi-mycotoxin method based on liquid chromatography/tandem mass spectrometry (LC-MS/MS) was used for a mycotoxin survey in 627 samples of processed cassava collected from different districts across Tanzania and Rwanda after the method performance for this matrix had been determined. Matrix effects as well as extraction efficiencies were found to be similar to most other previously investigated matrices with the exception of distinct matrix effects in the negative ionisation mode for early eluting compounds. Limits of detection were far below the regulatory limits set in the European Union for other types of commodities. Relative standard deviations were generally lower than 10% as determined by replicates spiked on two concentration levels. The sample-to-sample variation of the apparent recoveries was determined for 15 individually spiked samples during three different analytical sequences. The related standard deviation was found to be lower than 15% for most of the investigated compounds, thus confirming the applicability of the method for quantitative analysis. The occurrence of regulated mycotoxins was lower than 10% (with the exception of zearalenone) and the related limits were exceeded only in few samples, which suggests that cassava is a comparatively safe commodity as regards mycotoxins. The most prevalent fungal metabolites were emodin, kojic acid, beauvericin, tryptophol, 3-nitropropionic acid, equisetin, alternariol methylether, monocerin, brevianamide F, tenuazonic acid, zearalenone, chrysophanol, monilifomin, enniatins, apicidin and macrosporin. The related concentrations exceeded 1 mg kg(-1) only in few cases. However, extremely high levels of cyanogenic plant toxins, which had been previously added to the method, were observed in few samples, pointing out the need for improved post-harvest management to decrease the levels of these compounds.
Published: 2014
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25. Cataractes liées à l’application prolongée de dermocorticoïdes : étude de 8 cas à Abidjan

Author: A. Ouattara, F. Coulibaly, A. Fanny, R. Bérété-Coulibaly, K. Gbe, S. Boni, and Y. Sangaré
Subjects: Gynecology, Ophthalmology, medicine.medical_specialty, Skin Lightening Preparation, Adrenal cortex hormones, business.industry, medicine, Steroid induced cataract, Cote d ivoire, business
Abstract: Resume Introduction La cataracte induite par les corticosteroides est une entite bien decrite depuis relativement longtemps, mais cette eventualite provoquee par leur application cutanee reste encore insuffisamment rapportee. Le but de cette etude etait de decrire la cataracte comme une des complications de l’utilisation abusive des dermocorticoides. Patients et methodes Chez huit patients ayant consulte pour baisse d’acuite visuelle, il a ete decouvert une cataracte bilaterale. La recherche d’etiologie probable n’a retenu pour ces atteintes que l’application cutanee de corticosteroides. En effet, le bilan de recherche entrepris et l’interrogatoire minutieux n’ont retrouve aucune autre etiologie. Resultats Huit patients, 6 femmes et 2 hommes ont presente une cataracte liee a l’application de dermocorticoide. L’âge des patients se situait entre 39 et 45 ans. La cataracte etait bilaterale et de type sous-capsulaire posterieure seule ou associee. La periode d’utilisation des corticosteroides variait de 5 a 10 ans. Les produits utilises etaient constitues d’un melange de produits chimiques dont les corticosteroides sous forme de savon de fabrication traditionnelle surtout, mais aussi de pommade ou d’autres formes de mixtures. Conclusion Les dermocorticoides induisent une cataracte sous-capsulaire posterieure. Le mecanisme d’action est un acces direct a l’œil sans effet premier passage hepatique du corticoide incrimine. L’utilisation de plus en plus frequente de dermocorticoides en Afrique noire pour s’eclaircir la peau fait craindre le risque d’explosion de cataractes chez les jeunes femmes dont l’objectif est de s’eclaircir la peau pour disent elles se rendre belle. Une sensibilisation accrue merite d’etre entreprise pour prevenir ce phenomene, croissant et nocif.
Published: 2014
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26. Amniotic band syndrome (ABS): can something be done during pregnancy in African poor countries? Three cases and review of the literature

Author: S. Boni, G. Aissi, K.L.P. Nguessan, and D.B. Mian
Subjects: Reproductive Medicine, Obstetrics and Gynecology
Published: 2014
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27. Quand le ptérygion rend aveugle !!!

Author: K L J Kouassi, O A S Ouattara, E Gombe, Y G Ouffoue, V Ilupeju, A. Fanny, N J A Cheucheu, A J Konan, and S. Boni
Subjects: Ophthalmology, medicine.medical_specialty, Blindness, business.industry, Medicine, business, medicine.disease, Pterygium
Published: 2018
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28. Late diagnosis of positive HIV serology in pregnancy incidentally discovered by the widespread appearance of Kaposi’s sarcoma

Author: S. Boni, H. Iloki, K.L.P. Nguessan, E. Gbary, V. Angoi, C. Itoua, and D.B. Mian
Subjects: Reproductive Medicine, Obstetrics and Gynecology
Published: 2015
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29. Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post-Hoc Analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial

Author: Marco Dauriz, Giovanni Targher, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Gian Luigi Nicolosi, Roberto Marchioli, Gianni Tognoni, Roberto Latini, Franco Cosmi, Luigi Tavazzi, Aldo Pietro Maggioni, Simona Barlera, Maria Grazia Franzosi, Aldo P. Maggioni, Maurizio Porcu, Salim Yusuf, Fulvio Camerini, Jay N. Cohn, Adriano Decarli, Bertram Pitt, Peter Sleight, Philip A. Poole‐Wilson, Enrico Geraci, Marino Scherillo, Gianna Fabbri, Barbara Bartolomei, Daniele Bertoli, Franco Cobelli, Claudio Fresco, Antonietta Ledda, Giacomo Levantesi, Cristina Opasich, Franco Rusconi, Gianfranco Sinagra, Fabio Turazza, Alberto Volpi, Martina Ceseri, Gianluca Alongi, Antonio Atzori, Filippo Bambi, Desiree Bastarolo, Francesca Bianchini, Iacopo Cangioli, Vittoriana Canu, Concetta Caporusso, Gabriele Cenni, Laura Cintelli, Michele Cocchio, Alessia Confente, Eva Fenicia, Giorgio Friso, Marco Gianfriddo, Gianluca Grilli, Beatrice Lazzaro, Giuseppe Lonardo, Alessia Luise, Rachele Nota, Mariaelena Orlando, Rosaria Petrolo, Chiara Pierattini, Valeria Pierota, Alessandro Provenzani, Velia Quartuccio, Anna Ragno, Chiara Serio, Alvise Spolaor, Arianna Tafi, Elisa Tellaroli, Stefano Ghio, Elisa Ghizzardi, Serge Masson, Lella Crociati, Maria Teresa La Rovere, Ugo Corrà, Andrea Finzi, Marco Gorini, Valentina Milani, Giampietro Orsini, Elisa Bianchini, Silvia Cabiddu, Ilaria Cangioli, Laura Cipressa, Maria Lucia Cipressa, Giuseppina Di Bitetto, Barbara Ferri, Luisa Galbiati, Andrea Lorimer, Carla Pera, Paola Priami, Antonella Vasamì, T. Moccetti, M.G. Rossi, E. Pasotti, F. Vaghi, P. Roncarolo, M.T. Zunino, F. Matta, E. Actis Perinetto, F. Gaita, G. Azzaro, M. Zanetta, A.M. Paino, U. Parravicini, D. Vegis, R. Conte, P. Ferraro, A. De Bernardi, S. Morelloni, M. Fagnani, P. Greco Lucchina, L. Montagna, E. Bellone, D. Sappè, F. Ferraro, M. Delucchi, S.G. Reynaud, M. Dore, A. La Brocca, N. Massobrio, L. Bo, R. Trinchero, M. Imazio, G. Brocchi, A. Nejrotti, L. Rissone, S. Gabasio, C. Zocchi, S. Randazzo, A. Crenna, P. Giannuzzi, E. Bonanomi, A. Mezzani, M. De Marchi, G. Begliuomini, C.A. Gianonatti, A. Gavazzi, A. Grosu, L. Dei Cas, S. Nodari, P. Garyfallidis, A. Bertoletti, C. Bonifazi, S. Arisi, F. Mascaro, M. Fraccarollo, S. Dell'Orto, M. Sfolcini, F. Bortolini, D. Raccagni, A. Turelli, M. Santarone, E. Miglierina, L. Sormani, R. Jemoli, F. Tettamanti, S. Pirelli, C. Bianchi, S. Verde, M. Mariani, V. Ziacchi, A. Ferrazza, A. Russo, M. Bortolotti, G.F. Pasini, A. Volpi, K.N. Jones, D. Cuzzucrea, G. Gullace, C. Carbone, A. Granata, S. De Servi, G. Del Rosso, C. Inserra, E. Renaldini, C. Zappa, M. Moretti, R. Zanini, M. Ferrari, E. Moroni, A. Cei, C. Lissi, E. Dovico, C. Fiorentini, P. Palermo, B. Brusoni, M. Negrini, J. Heyman, G.B. Danzi, A. Finzi, M. Frigerio, F. Turazza, L. Beretta, A. Sachero, F. Casazza, L. Squadroni, F. Lombardi, L. Marano, A. Margonato, G. Fragasso, O.C. Febo, E. Aiolfi, F. Olmetti, A. Grieco, V. Antonazzo, G. Specchia, A. Mortara, F. Robustelli, M.G. Songini, C. Schweiger, A. Frisinghelli, M. Palvarini, C. Campana, L. Scelsi, N. Ajmone Marsan, F. Cobelli, A. Gualco, C. Opasich, S. De Feo, R. Mazzucco, M.A. Iannone, T. Diaco, D. Zaniboni, G. Milanesi, D. Nassiacos, S. Meloni, P. Giani, T. Nicoli, C. Malinverni, A. Gusmini, L. Pozzoni, G. Bisiani, P. Margaroli, A. Schizzarotto, A. Daverio, G. Occhi, N. Partesana, P. Bandini, M.G. Rosella, S. Giustiniani, G. Cucchi, R. Pedretti, R. Raimondo, R. Vaninetti, A. Fedele, I. Ghezzi, E. Rezzonico, J.A. Salerno Uriarte, F. Morandi, F. Salvucci, C. Valenti, G. Graziano, M. Romanò, C. Cimminiello, I. Mangone, M. Lombardo, P. Quorso, G. Marinoni, M. Breghi, M. Erckert, A. Dienstl, G. Mirante Marini, C. Stefenelli, G. Cioffi, E. Buczkowska, A. Bonanome, F. Bazzanini, L. Parissenti, C. Serafini, G. Catania, L. Tarantini, G. Rigatelli, S. Boni, A. Pasini, E. Masini, A.A. Zampiero, M. Zanchetta, L. Franceschetto, P. Delise, C. Marcon, A. Sacchetta, L. Borgese, L. Artusi, P. Casolino, F. Corbara, A. Banzato, M. Barbiero, M.P. Aldegheri, R. Bazzucco, G. Crivellenti, A. Raviele, C. Zanella, P. Pascotto, P. Sarto, S. Milan, E. Barbieri, P. Girardi, W. Dalla Villa, J. Dalle Mule, M.L. Di Sipio, R. Cazzin, D. Milan, P. Zonzin, M. Carraro, R. Rossi, E. Carbonieri, I. Rossi, P. Stritoni, P. Meneghetti, G. Risica, P.L. Tenderini, C. Vassanelli, L. Zanolla, G. Perini, G. Brighetti, R. Chiozza, G. Giuliano, R. Gortan, R. Cesanelli, G.L. Nicolosi, R. Piazza, L. Mos, O. Vriz, D. Pavan, G. Pascottini, E. Alberti, M. Werren, L. Solinas, G. Sinagra, F. Longaro, P. Fioretti, M.C. Albanese, D. Miani, R. Gianrossi, A. Pende, P. Rubartelli, O. Magaia, S. Domenicucci, D. Caruso, A.S. Faraguti, L. Magliani, F. Miccoli, G. Guglielmino, D. Bertoli, A. Cantarelli, S. Orlandi, A. Vallebona, A. Pozzati, G. Brega, L.G. Pancaldi, R. Vandelli, S. Urbinati, M.G. Poci, M. Zoli, G.M. Costa, U. Guiducci, G. Zobbi, F. Tartagni, A. Tisselli, A. Gentili, P. Pieri, E. Cagnetta, S. Bendinelli, A. Barbieri, R. Conti, R. Ferrari, F. Merlini, A. Fucili, P. Moruzzi, E. Buia, M. Galvani, D. Ferrini, G. Baggioni, P. Yiannacopulu, G. Canè, A. Bonfiglioli, R. Zandomeneghi, L. Brugioni, A. Giannini, R. Di Ruvo, M. Giuliani, L. Rusconi, P. Del Corso, G. Piovaccari, F. Bologna, P. Venturi, F. Melandri, E. Bagni, L. Bolognese, R. Perticucci, A. Zuppiroli, M. Nannini, N. Consoli, P. Petrone, C. Pipitò, L. Colombi, D. Bernardi, P.R. Mariani, R. Testa, F. Mazzinghi, F. Cosmi, D. Cosmi, A. Zipoli, A. Cecchi, G. Castelli, M. Ciaccheri, F. Mori, F. Pieri, P. Valoti, D. Chiarantini, G.M. Santoro, C. Minneci, F. Marchi, M. Milli, G. Zambaldi, A.A. Brandinelli Geri, M. Cipriani, M. Alessandri, S. Severi, S. Stefanelli, A. Comella, R. Poddighe, A. Digiorgio, M. Carluccio, S. Berti, A. Rizza, V. Bonatti, V. Molendi, A. Brancato, N. D'Aprile, G. Giappichini, S. Del Vecchio, G. Mantini, F. De Tommasi, G. Meucci, M. Cordoni, S. Bechi, L. Barsotti, P. Baldini, M. Romei, G. Scopelliti, G. Lauri, F. Pestelli, F. Furiozzi, M. Cocchieri, D. Severini, F. Patriarchi, P. Chiocchi, M. Buccolieri, S. Martinelli, A. Wee, F. Angelici, M. Bernardinangeli, G. Proietti, B. Biscottini, R. Panciarola, L. Marinacci, G.P. Perna, D. Gabrielli, A. Moraca, L. Moretti, L. Partemi, G. Gregori, R. Amici, G. Patteri, P. Capone, E. Savini, G.L. Morgagni, L. Paccaloni, F. Pezzuoli, S. Carincola, S. Papi, S. De Crescentini, P. Gerardi, P. Midi, E. Gallenzi, G. Pajes, C. Mancone, V. Di Spirito, M. Di Gennaro, S. Calcagno, S. Toscano, S. Antonicoli, F. Carta, G. Giorgi, F. Comito, E. Daniele, O. Ciarla, P.G. Gelfo, A. Acquaviva, D. Testa, G. Testa, F.A. Pagliaro, F. Russo, F. Vetta, I. Marchese, G. Di Sciascio, A. D'Ambrosio, F. Leggio, D. Del Sindaco, A. Lacchè, A. Avallone, M.P. Risa, P. Azzolini, E. Baldo, E. Giovannini, G. Pulignano, C. Tondo, E. Picchio, E. ani, P. Tanzi, F. Pozzar, F. Farnetti, M. Azzarito, M. Santini, A. Varveri, G. Ferraiuolo, C. Valtorta, A. Gaspardone, G. Barbato, V. Ceci, N. Aspromonte, F. Bellocci, C. Colizzi, F. Fedele, F.I. Perez, A. Galati, A. Rossetti, A. Mainella, D. etta, C. Matteucci, G. Busi, A. De Angelis, G. Farina, A. Granatelli, F. Leone, F. Frasca, R. Di Giovambattista, G. Castellani, G. Massaro, G. Mastrogiuseppe, A. Vacri, F. De Sanctis, M. Cioli, S. Di Luzio, C. Napoletano, L.L. Piccioni, G. De Simone, A. Ottaviano, V. Mazza, C. Spedaliere, D. Staniscia, E. Calgione, G. De Marco, T. Chiacchio, T. Di Napoli, S. Romanzi, G. Salvatore, P. Golino, A. Palermo, F. Mascia, A. Vetrano, A. Vinciguerra, L. Caliendo, R. Longobardi, G. De Caro, R. Di Nola, F. Piemonte, D. Prinzi, P. De Rosa, V. De Rosa, F. Riello, V. Capuano, G. Vecchio, M. Landi, S. Amato, M. Garofalo, M. D'Avino, P. Sensale, O. Maiolica, R. Santoro, P. Caso, D. Miceli, N. Maurea, U. Bianchi, C. Crispo, M. Chiariello, P. Perrone Filardi, L. Russo, N. Capuano, G. Ungaro, G. Vergara, F. Scafuro, G. D'Angelo, C. Campaniello, P. Bottiglieri, A. Volpe, R. Battista, L. De Risi, G. Cardillo, G. Sibilio, A.P. Marino, F. Silvestri, P. Predotti, A. Iervoglini, C. De Matteis, P. Sarnicola, M.M. Matarazzo, S. Baldi, V. Iuliano, C. Astarita, P. Cuccaro, A. Liguori, G. Liguori, G. Gregorio, L. Petraglia, G. Antonelli, G. Amodio, I. De Luca, D. Traversa, G. Franchini, M.L. Lenti, D. Cavallari, C. D'Agostino, G. Scalera, C.M. Altamura, M. Russo, A.R. Mascolo, G. Pettinati, S.A. Ciricugno, D. Scrutinio, A. Passantino, D. Mastrangelo, A. Di Masi, R. De Carne, M. Cannone, F. Dibiase, M. Pensato, F. Loliva, F. Trapani, I. Panettieri, L. Leone, M. Di Biase, M. Carrone, V. Gallone, F. Cocco, M. Costantini, C. Tritto, F. Cavalieri, L. Stella, F. Magliari, M. Callerame, A. De Giorgi, L. Pellegrino, M. Correra, V. Portulano, G.L. Nisi, G. Grassi, E. Cristallo, D. De Laura, C. Salerno, R. Fanelli, M. Villella, S. Pede, A. Renna, E. De Lorenzi, L. Urso, V. Lenti, A. Peluso, N. Baldi, G. Polimeni, P. Palma, R. Lauletta, E. Tagliamonte, T. Cirillo, B. Silvestri, G. Centonze, B. D'Alessandro, L. Truncellito, D. Mecca, M.A. Petruzzi, R.O.M. Coviello, A. Lopizzo, M. telli, S. Barbuzzi, S. Gubelli, G. Germinario, N. Cosentino, A. Mingrone, R. Vico, G. Borrello, M.L. Mazza, R. Cimino, D. Galasso, F. Cassadonte, U. Talarico, F. Perticone, S. Cassano, F. Catapano, S. Calemme, E. Feraco, C. Cloro, G. Misuraca, R. Caporale, L. Vigna, V. Spagnuolo, F. De Rosa, G. Spadafora, G. Zampaglione, R. Russo, F.A. Schipani, A.F. Ferragina, D. Stranieri, G. Musca, C. Carpino, P. Bencardino, F. Raimondo, D. Musacchio, G. Pulitanò, A. Ruggeri, A. Provenzano, S. Salituri, M. Musolino, S. Calandruccio, A. Marrari, E. Tripodi, R. Scali, L. Anastasio, A. Arone, P. Aragona, L. Donnangelo, M.G.A. Comito, F. Bilotta, I. Vaccaro, R. Rametta, V. Ventura, A. Bonvegna, A. Alì, C. Cinnirella, M. Raineri, F. Pompeo, N. Cascio Ingurgio, V. Carini, R. Coco, G. Giunta, G. Leonardi, V. Randazzo, V. Di Blasi, C. Tamburino, G. Russo, S. Mangiameli, R. Cardillo, D. Castelli, V. Inserra, A. Arena, M.M. Gulizia, S. Raciti, G. Rapisarda, R. Romano, P. Prestifilippo, G.B. Braschi, G. Ledda, R. Terrazzino, M. De Caro, G. Scilabra, B. agnino, R. Grassi, G. Di Tano, G.F. Scimone, L. Vasquez, C. Coppolino, A. Casale, M. Castelli, G. D'Urso, E. D'Antonio, L. Lo Presti, E. Badalamenti, P. Conti, N. Sanfilippo, V. Cirrincione, M.T. Cinà, G. Cusimano, A. Taormina, P. Giuliano, A. Bajardi, V. Mandalà, A. Canonico, G. Geraci, F.P. Sabella, F. Enia, A.M. Floresta, I. Lo Cascio, D. Gumina, A. Cavallaro, G. Piccione, R. Ferrante, M. Blandino, M.S. Iudicello, E. Mossuti, G. Romano, L. Lombardo, P. Monastra, D. Di Vincenzo, M. Porcu, P. Orrù, F. Muscas, G. Giardina, M. Corda, G. Locci, A. Podda, M. Ledda, P. Siddi, C. Lai, G. Pili, G. Mercuro, G. Mureddu, A. Ganau, G. Meloni, G. Poddighe, G. Sanna, Dauriz, Marco, Targher, Giovanni, Temporelli, Pier Luigi, Lucci, Donata, Gonzini, Lucio, Nicolosi, Gian Luigi, Marchioli, Roberto, Tognoni, Gianni, Latini, Roberto, Cosmi, Franco, Tavazzi, Luigi, Maggioni, Aldo Pietro, on behalf of the GISSI-HF, Investigator, Margonato, Alberto, Moccetti, T., Rossi, M. G., Pasotti, E., Vaghi, F., Roncarolo, P., Zunino, M. T., Matta, F., Actis Perinetto, E., Gaita, F., Azzaro, G., Zanetta, M., Paino, A. M., Parravicini, U., Vegis, D., Conte, R., Ferraro, P., De Bernardi, A., Morelloni, S., Fagnani, M., Greco Lucchina, P., Montagna, L., Bellone, E., Sappè, D., Ferraro, F., Delucchi, M., Reynaud, S. G., Dore, M., La Brocca, A., Massobrio, N., Bo, L., Trinchero, R., Imazio, M., Brocchi, G., Nejrotti, A., Rissone, L., Gabasio, S., Zocchi, C., Randazzo, S., Crenna, A., Giannuzzi, P., Bonanomi, E., Mezzani, A., De Marchi, M., Begliuomini, G., Gianonatti, C. A., Gavazzi, A., Grosu, A., Dei Cas, L., Nodari, S., Garyfallidis, P., Bertoletti, A., Bonifazi, C., Arisi, S., Mascaro, F., Fraccarollo, M., Dell'Orto, S., Sfolcini, M., Bortolini, F., Raccagni, D., Turelli, A., Santarone, M., Miglierina, E., Sormani, L., Jemoli, R., Tettamanti, F., Pirelli, S., Bianchi, C., Verde, S., Mariani, M., Ziacchi, V., Ferrazza, A., Russo, A., Bortolotti, M., Pasini, G. F., Volpi, A., Jones, K. N., Cuzzucrea, D., Gullace, G., Carbone, C., Granata, A., De Servi, S., Del Rosso, G., Inserra, C., Renaldini, E., Zappa, C., Moretti, M., Zanini, R., Ferrari, M., Moroni, E., Cei, A., Lissi, C., Dovico, E., Fiorentini, C., Palermo, P., Brusoni, B., Negrini, M., Heyman, J., Danzi, G. B., Finzi, A., Frigerio, M., Turazza, F., Beretta, L., Sachero, A., Casazza, F., Squadroni, L., Lombardi, F., Marano, L., Margonato, A., Fragasso, G., Febo, O. C., Aiolfi, E., Olmetti, F., Grieco, A., Antonazzo, V., Specchia, G., Mortara, A., Robustelli, F., Songini, M. G., Schweiger, C., Frisinghelli, A., Palvarini, M., Campana, C., Scelsi, L., Ajmone Marsan, N., Cobelli, F., Gualco, A., Opasich, C., De Feo, S., Mazzucco, R., Iannone, M. A., Diaco, T., Zaniboni, D., Milanesi, G., Nassiacos, D., Meloni, S., Giani, P., Nicoli, T., Malinverni, C., Gusmini, A., Pozzoni, L., Bisiani, G., Margaroli, P., Schizzarotto, A., Daverio, A., Occhi, G., Partesana, N., Bandini, P., Rosella, M. G., Giustiniani, S., Cucchi, G., Pedretti, R., Raimondo, R., Vaninetti, R., Fedele, A., Ghezzi, I., Rezzonico, E., Salerno Uriarte, J. A., Morandi, F., Salvucci, F., Valenti, C., Graziano, G., Romanò, M., Cimminiello, C., Mangone, I., Lombardo, M., Quorso, P., Marinoni, G., Breghi, M., Erckert, M., Dienstl, A., Mirante Marini, G., Stefenelli, C., Cioffi, G., Buczkowska, E., Bonanome, A., Bazzanini, F., Parissenti, L., Serafini, C., Catania, G., Tarantini, L., Rigatelli, G., Boni, S., Pasini, A., Masini, E., Zampiero, A. A., Zanchetta, M., Franceschetto, L., Delise, P., Marcon, C., Sacchetta, A., Borgese, L., Artusi, L., Casolino, P., Corbara, F., Banzato, A., Barbiero, M., Aldegheri, M. P., Bazzucco, R., Crivellenti, G., Raviele, A., Zanella, C., Pascotto, P., Sarto, P., Milan, S., Barbieri, E., Girardi, P., Dalla Villa, W., Dalle Mule, J., Di Sipio, M. L., Cazzin, R., Milan, D., Zonzin, P., Carraro, M., Rossi, R., Carbonieri, E., Rossi, I., Stritoni, P., Meneghetti, P., Risica, G., Tenderini, P. L., Vassanelli, C., Zanolla, L., Perini, G., Brighetti, G., Chiozza, R., Giuliano, G., Baldin, M. G., Gortan, R., Cesanelli, R., Nicolosi, G. L., Piazza, R., Mos, L., Vriz, O., Pavan, D., Pascottini, G., Alberti, E., Werren, M., Solinas, L., Sinagra, G., Longaro, F., Fioretti, P., Albanese, M. C., Miani, D., Gianrossi, R., Pende, A., Rubartelli, P., Magaia, O., Domenicucci, S., Caruso, D., Faraguti, A. S., Magliani, L., Miccoli, F., Guglielmino, G., Bertoli, D., Cantarelli, A., Orlandi, S., Vallebona, A., Pozzati, A., Brega, G., Pancaldi, L. G., Vandelli, R., Urbinati, S., Poci, M. G., Zoli, M., Costa, G. M., Guiducci, U., Zobbi, G., Tartagni, F., Tisselli, A., Gentili, A., Pieri, P., Cagnetta, E., Bendinelli, S., Barbieri, A., Conti, R., Ferrari, R., Merlini, F., Fucili, A., Moruzzi, P., Buia, E., Galvani, M., Ferrini, D., Baggioni, G., Yiannacopulu, P., Canè, G., Bonfiglioli, A., Zandomeneghi, R., Brugioni, L., Giannini, A., Di Ruvo, R., Giuliani, M., Rusconi, L., Del Corso, P., Piovaccari, G., Bologna, F., Venturi, P., Melandri, F., Bagni, E., Bolognese, L., Perticucci, R., Zuppiroli, A., Nannini, M., Consoli, N., Petrone, P., Pipitò, C., Colombi, L., Bernardi, D., Mariani, P. R., Testa, R., Mazzinghi, F., Cosmi, F., Cosmi, D., Zipoli, A., Cecchi, A., Castelli, G., Ciaccheri, M., Mori, F., Pieri, F., Valoti, P., Chiarantini, D., Santoro, G. M., Minneci, C., Marchi, F., Milli, M., Zambaldi, G., Brandinelli Geri, A. A., Cipriani, M., Alessandri, M., Severi, S., Stefanelli, S., Comella, A., Poddighe, R., Digiorgio, A., Carluccio, M., Berti, S., Rizza, A., Bonatti, V., Molendi, V., Brancato, A., D'Aprile, N., Giappichini, G., Del Vecchio, S., Mantini, G., De Tommasi, F., Meucci, G., Cordoni, M., Bechi, S., Barsotti, L., Baldini, P., Romei, M., Scopelliti, G., Lauri, G., Pestelli, F., Furiozzi, F., Cocchieri, M., Severini, D., Patriarchi, F., Chiocchi, P., Buccolieri, M., Martinelli, S., Wee, A., Angelici, F., Bernardinangeli, M., Proietti, G., Biscottini, B., Panciarola, R., Marinacci, L., Perna, G. P., Gabrielli, D., Moraca, A., Moretti, L., Partemi, L., Gregori, G., Amici, R., Patteri, G., Capone, P., Savini, E., Morgagni, G. L., Paccaloni, L., Pezzuoli, F., Carincola, S., Papi, S., De Crescentini, S., Gerardi, P., Midi, P., Gallenzi, E., Pajes, G., Mancone, C., Di Spirito, V., Di Gennaro, M., Calcagno, S., Toscano, S., Antonicoli, S., Carta, F., Giorgi, G., Comito, F., Daniele, E., Ciarla, O., Gelfo, P. G., Acquaviva, A., Testa, D., Testa, G., Pagliaro, F. A., Russo, F., Vetta, F., Marchese, I., Di Sciascio, G., D'Ambrosio, A., Leggio, F., Del Sindaco, D., Lacchè, A., Avallone, A., Risa, M. P., Azzolini, P., Baldo, E., Giovannini, E., Pulignano, G., Tondo, C., Picchio, E., Biffani, E., Tanzi, P., Pozzar, F., Farnetti, F., Azzarito, M., Santini, M., Varveri, A., Ferraiuolo, G., Valtorta, C., Gaspardone, A., Barbato, G., Ceci, V., Aspromonte, N., Bellocci, F., Colizzi, C., Fedele, F., Perez, F. I., Galati, A., Rossetti, A., Mainella, A., Ciuffetta, D., Matteucci, C., Busi, G., De Angelis, A., Farina, G., Granatelli, A., Leone, F., Frasca, F., Di Giovambattista, R., Castellani, G., Massaro, G., Mastrogiuseppe, G., Vacri, A., De Sanctis, F., Cioli, M., Di Luzio, S., Napoletano, C., Piccioni, L. L., De Simone, G., Ottaviano, A., Mazza, V., Spedaliere, C., Staniscia, D., Calgione, E., De Marco, G., Chiacchio, T., Di Napoli, T., Romanzi, S., Salvatore, G., Golino, P., Palermo, A., Mascia, F., Vetrano, A., Vinciguerra, A., Caliendo, L., Longobardi, R., De Caro, G., Di Nola, R., Piemonte, F., Prinzi, D., De Rosa, P., De Rosa, V., Riello, F., Capuano, V., Vecchio, G., Landi, M., Amato, S., Garofalo, M., D'Avino, M., Sensale, P., Maiolica, O., Santoro, R., Caso, P., Miceli, D., Maurea, N., Bianchi, U., Crispo, C., Chiariello, M., Perrone Filardi, P., Russo, L., Capuano, N., Ungaro, G., Vergara, G., Scafuro, F., D'Angelo, G., Campaniello, C., Bottiglieri, P., Volpe, A., Battista, R., De Risi, L., Cardillo, G., Sibilio, G., Marino, A. P., Silvestri, F., Predotti, P., Iervoglini, A., De Matteis, C., Sarnicola, P., Matarazzo, M. M., Baldi, S., Iuliano, V., Astarita, C., Cuccaro, P., Liguori, A., Liguori, G., Gregorio, G., Petraglia, L., Antonelli, G., Amodio, G., De Luca, I., Traversa, D., Franchini, G., Lenti, M. L., Cavallari, D., D'Agostino, C., Scalera, G., Altamura, C. M., Russo, M., Mascolo, A. R., Pettinati, G., Ciricugno, S. A., Scrutinio, D., Passantino, A., Mastrangelo, D., Di Masi, A., De Carne, R., Cannone, M., Dibiase, F., Pensato, M., Loliva, F., Trapani, F., Panettieri, I., Leone, L., Di Biase, M., Carrone, M., Gallone, V., Cocco, F., Costantini, M., Tritto, C., Cavalieri, F., Stella, L., Magliari, F., Callerame, M., De Giorgi, A., Pellegrino, L., Correra, M., Portulano, V., Nisi, G. L., Grassi, G., Cristallo, E., De Laura, D., Salerno, C., Fanelli, R., Villella, M., Pede, S., Renna, A., De Lorenzi, E., Urso, L., Lenti, V., Peluso, A., Baldi, N., Polimeni, G., Palma, P., Lauletta, R., Tagliamonte, E., Cirillo, T., Silvestri, B., Centonze, G., D'Alessandro, B., Truncellito, L., Mecca, D., Petruzzi, M. A., Coviello, R. O. M., Lopizzo, A., Chiaffitelli, M., Barbuzzi, S., Gubelli, S., Germinario, G., Cosentino, N., Mingrone, A., Vico, R., Borrello, G., Mazza, M. L., Cimino, R., Galasso, D., Cassadonte, F., Talarico, U., Perticone, F., Cassano, S., Catapano, F., Calemme, S., Feraco, E., Cloro, C., Misuraca, G., Caporale, R., Vigna, L., Spagnuolo, V., De Rosa, F., Spadafora, G., Zampaglione, G., Russo, R., Schipani, F. A., Ferragina, A. F., Stranieri, D., Musca, G., Carpino, C., Bencardino, P., Raimondo, F., Musacchio, D., Pulitanò, G., Ruggeri, A., Provenzano, A., Salituri, S., Musolino, M., Calandruccio, S., Marrari, A., Tripodi, E., Scali, R., Anastasio, L., Arone, A., Aragona, P., Donnangelo, L., Comito, M. G. A., Bilotta, F., Vaccaro, I., Rametta, R., Ventura, V., Bonvegna, A., Alì, A., Cinnirella, C., Raineri, M., Pompeo, F., Cascio Ingurgio, N., Carini, V., Coco, R., Giunta, G., Leonardi, G., Randazzo, V., Di Blasi, V., Tamburino, C., Russo, G., Mangiameli, S., Cardillo, R., Castelli, D., Inserra, V., Arena, A., Gulizia, M. M., Raciti, S., Rapisarda, G., Romano, R., Prestifilippo, P., Braschi, G. B., Ledda, G., Terrazzino, R., De Caro, M., Scilabra, G., Graffagnino, B., Grassi, R., Di Tano, G., Scimone, G. F., Vasquez, L., Coppolino, C., Casale, A., Castelli, M., D'Urso, G., D'Antonio, E., Lo Presti, L., Badalamenti, E., Conti, P., Sanfilippo, N., Cirrincione, V., Cinà, M. T., Cusimano, G., Taormina, A., Giuliano, P., Bajardi, A., Mandalà, V., Canonico, A., Geraci, G., Sabella, F. P., Enia, F., Floresta, A. M., Lo Cascio, I., Gumina, D., Cavallaro, A., Piccione, G., Ferrante, R., Blandino, M., Iudicello, M. S., Mossuti, E., Romano, G., Lombardo, L., Monastra, P., Di Vincenzo, D., Porcu, M., Orrù, P., Muscas, F., Giardina, G., Corda, M., Locci, G., Podda, A., Ledda, M., Siddi, P., Lai, C., Pili, G., Mercuro, G., Mureddu, G., Ganau, A., Meloni, G., Poddighe, G., Sanna, G., Barlera, Simona, Franzosi, Maria Grazia, Porcu, Maurizio, Yusuf, Salim, Camerini, Fulvio, Cohn, Jay N., Decarli, Adriano, Pitt, Bertram, Sleight, Peter, Poole-Wilson, Philip A., Geraci, Enrico, Scherillo, Marino, Fabbri, Gianna, Bartolomei, Barbara, Bertoli, Daniele, Cobelli, Franco, Fresco, Claudio, Ledda, Antonietta, Levantesi, Giacomo, Opasich, Cristina, Rusconi, Franco, Sinagra, Gianfranco, Turazza, Fabio, Volpi, Alberto, Ceseri, Martina, Alongi, Gianluca, Atzori, Antonio, Bambi, Filippo, Bastarolo, Desiree, Bianchini, Francesca, Cangioli, Iacopo, Canu, Vittoriana, Caporusso, Concetta, Cenni, Gabriele, Cintelli, Laura, Cocchio, Michele, Confente, Alessia, Fenicia, Eva, Friso, Giorgio, Gianfriddo, Marco, Grilli, Gianluca, Lazzaro, Beatrice, Lonardo, Giuseppe, Luise, Alessia, Nota, Rachele, Orlando, Mariaelena, Petrolo, Rosaria, Pierattini, Chiara, Pierota, Valeria, Provenzani, Alessandro, Quartuccio, Velia, Ragno, Anna, Serio, Chiara, Spolaor, Alvise, Tafi, Arianna, Tellaroli, Elisa, Ghio, Stefano, Ghizzardi, Elisa, Masson, Serge, Crociati, Lella, La Rovere, Maria Teresa, Corrà, Ugo, Di Giulio, Paola, Finzi, Andrea, Gorini, Marco, Milani, Valentina, Orsini, Giampietro, Bianchini, Elisa, Cabiddu, Silvia, Cangioli, Ilaria, Cipressa, Laura, Cipressa, Maria Lucia, Di Bitetto, Giuseppina, Ferri, Barbara, Galbiati, Luisa, Lorimer, Andrea, Pera, Carla, Priami, Paola, and Vasamì, Antonella
Subjects: Blood Glucose, Male, Glycated Hemoglobin A, heart failure, Kaplan-Meier Estimate, prediabetes, 030204 cardiovascular system & hematology, time factors, Settore MED/11, cause of death, 0302 clinical medicine, Glycemic control, prediabetic state, Cause of Death, italy, middle aged, Prevalence, 80 and over, double-blind method, blood glucose, risk factors, 030212 general & internal medicine, Prediabetes, Rosuvastatin Calcium, humans, rosuvastatin calcium, Cause of death, Original Research, Metabolic Syndrome, Aged, 80 and over, adult, Chronic heart failure, Diabetes mellitus, Heart failure, Mortality, Cardiology and Cardiovascular Medicine, Hazard ratio, chronic heart failure, diabetes mellitus, glycemic control, mortality, Treatment Outcome, Adolescent, Biomarkers, Chronic Disease, Diabetes Mellitus, Fatty Acids, Omega-3, Double-Blind Method, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hospitalization, Heart Failure, Italy, Prediabetic State, Risk Assessment, Proportional Hazards Models, Risk Factors, Time Factors, risk assessment, Middle Aged, kaplan-meier estimate, aged, female, Prediabete, young adult, Female, omega-3, Human, hospitalization, Adult, medicine.medical_specialty, Diabetes mellitu, proportional hazards models, Time Factor, hydroxymethylglutaryl-coa reductase inhibitors, prevalence, fatty acids, 03 medical and health sciences, Young Adult, male, Internal medicine, Post-hoc analysis, glycated hemoglobin a, medicine, Intensive care medicine, Aged, Glycated Hemoglobin, Proportional hazards model, business.industry, Risk Factor, biomarkers, Biomarker, medicine.disease, Clinical trial, adolescent, Proportional Hazards Model, treatment outcome, aged, 80 and over, chronic disease, fatty acids, omega-3, cardiology and cardiovascular medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitor, business
Abstract: Background The independent prognostic impact of diabetes mellitus ( DM ) and prediabetes mellitus (pre‐ DM ) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre‐ DM on survival outcomes in the GISSI ‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) trial. Methods and Results We assessed the risk of all‐cause death and the composite of all‐cause death or cardiovascular hospitalization over a median follow‐up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI ‐ HF trial, who were stratified by presence of DM (n=2852), pre‐ DM (n=2013), and non‐ DM (n=2070) at baseline. Compared with non‐ DM patients, those with DM had remarkably higher incidence rates of all‐cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non‐ DM patients and those with pre‐ DM . Cox regression analysis showed that DM , but not pre‐ DM , was associated with an increased risk of all‐cause death (adjusted hazard ratio, 1.43; 95% CI , 1.28–1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI , 1.13–1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all‐cause death: adjusted hazard ratio, 1.21; 95% CI , 1.02–1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI , 1.01–1.29, respectively). Conclusions Presence of DM was independently associated with poor long‐term survival outcomes in patients with chronic heart failure. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 00336336.
Published: 2017
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30. A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Author: Li, D. Chang, X. Connolly, J.J. Tian, L. Liu, Y. Bhoj, E.J. Robinson, N. Abrams, D. Li, Y.R. Bradfield, J.P. Kim, C.E. Li, J. Wang, F. Snyder, J. Lemma, M. Hou, C. Wei, Z. Guo, Y. Qiu, H. Mentch, F.D. Thomas, K.A. Chiavacci, R.M. Cone, R. Li, B. Sleiman, P.A. Hakonarson, H. Perica, V.B. Franklin, C.S. Floyd, J.A.B. Thornton, L.M. Huckins, L.M. Southam, L. Rayner, N.W. Tachmazidou, I. Schmidt, U. Tozzi, F. Kiezebrink, K. Hebebrand, J. Gorwood, P. Adan, R.A.H. Kas, M.J.H. Favaro, A. Santonastaso, P. Fernánde-Aranda, F. Gratacos, M. Rybakowski, F. Dmitrzak-Weglarz, M. Kaprio, J. Keski-Rahkonen, A. Raevuori-Helkamaa, A. Furth, E.F.V. Slof-Opt Landt, M.C.T. Hudson, J.I. Reichborn-Kjennerud, T. Knudsen, G.P.S. Monteleone, P. Karwautz, A. Berrettini, W.H. Schork, N.J. Ando, T. Inoko, H. Esko, T. Fischer, K. Männik, K. Metspalu, A. Baker, J.H. DeSocio, J.E. Hilliard, C.E. O'Toole, J.K. Pantel, J. Szatkiewicz, J.P. Zerwas, S. Davis, O.S.P. Helder, S. Bühren, K. Burghardt, R. De Zwaan, M. Egberts, K. Ehrlich, S. Herpertz-Dahlmann, B. Herzog, W. Imgart, H. Scherag, A. Zipfel, S. Boni, C. Ramoz, N. Versini, A. Danner, U.N. Hendriks, J. Koeleman, B.P.C. Ophoff, R.A. Strengman, E. Van Elburg, A.A. Bruson, A. Clementi, M. Degortes, D. Forzan, M. Tenconi, E. Docampo, E. Escaramís, G. Jiménez-Murcia, S. Lissowska, J. Rajewski, A. Szeszenia-Dabrowska, N. Slopien, A. Hauser, J. Karhunen, L. Meulenbelt, I. Slagboom, P.E. Tortorella, A. Maj, M. Dedoussis, G. DIkeos, D. Gonidakis, F. Tziouvas, K. Tsitsika, A. Papezova, H. Slachtova, L. Martaskova, D. Kennedy, J.L. Levitan, R.D. Yilmaz, Z. Huemer, J. Koubek, D. Merl, E. Wagner, G. Lichtenstein, P. Breen, G. Cohen-Woods, S. Farmer, A. McGuffin, P. Cichon, S. Giegling, I. Herms, S. Rujescu, D. Schreiber, S. Wichmann, H.-E. DIna, C. Sladek, R. Gambaro, G. Soranzo, N. Julia, A. Marsal, S. Rabionet, R. Gaborieau, V. DIck, D.M. Palotie, A. Ripatti, S. Widén, E. Andreassen, O.A. Espeseth, T. Lundervold, A. Reinvang, I. Steen, V.M. Le Hellard, S. Mattingsdal, M. Ntalla, I. Bencko, V. Foretova, L. Janout, V. Navratilova, M. Gallinger, S. Pinto, D. Scherer, S.W. Aschauer, H. Carlberg, L. Schosser, A. Alfredsson, L. DIng, B. Klareskog, L. Padyukov, L. Finan, C. Kalsi, G. Roberts, M. Barrett, J.C. Estivill, X. Hinney, A. Sullivan, P.F. Zeggini, E. Bulik, C.M. Brandt, H. Crawford, S. Crow, S. Fichter, M.M. Halmi, K.A. Johnson, C. Kaplan, A.S. La Via, M.C. Mitchell, J. Strober, M. Rotondo, A. Treasure, J. Woodside, D.B. Keel, P.K. Klump, K.L. Lilenfeld, L. Bergen, A.W. Kaye, W. Magistretti, P.
Abstract: We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that approached genome-wide significance (rs929626 in EBF1 (Early B-Cell Factor 1); P = 2.04 × 10-7; OR = 0.7; 95% confidence interval (CI) = 0.61-0.8) with independent replication (P = 0.04), suggesting a variant-mediated dysregulation of leptin signaling may play a role in AN. Multiple SNPs in LD with the variant support the nominal association. This demonstrates that although the clinical and etiologic heterogeneity of AN is universally recognized, further careful sub-typing of cases may provide more precise genomic signals. In this study, through a refinement of the phenotype spectrum of AN, we present a replicable GWAS signal that is nominally associated with AN, highlighting a potentially important candidate locus for further investigation. © 2017 The Author(s).
Published: 2017

31. [Pseudo-tumoral invasive fungus infection of the maxillary sinus in Abidjan]

Author: A K, Tanon, C, Assouan, E, Anzouan-Kacou, D, N'guessan, A, Salami, S, Boni, and E, Konan
Subjects: Adult, Male, Antifungal Agents, Cote d'Ivoire, Orbital Pseudotumor, Aspergillosis, Exophthalmos, Humans, Itraconazole, Maxillary Sinus, Maxillary Sinusitis, Invasive Fungal Infections
Abstract: The invasive fungal infection of the maxillary sinus is a rare and serious disease generally favored by immunosuppression. We report an exceptional case of pseudotumoral invasive fungal infection of the maxillary sinus in an immunocompetent patient.A 32-year-old patient consulted for labial and left temporal swelling associated with proptosis and chemosis that has been developing for 18 months. The scanner objectified a filling of the left maxillary sinus, and the ipsilateral orbital cavity, and the surrounding muscles. Histological examination of the surgical specimen revealed invasive fungal infection of the left maxillary sinus. The relevant antifungal therapy, namely voriconazole, could not be administered due to the unavailability of the medicine. However, the patient has received 200mg of itraconazole every 12hours for three weeks. The change proved disappointing with recurrence and significant sequelae, sort of sagging of the right hemifacial, severe limitation of mouth opening and functional loss of the right eye.The invasive fungus infections of the maxillary sinus and the orbit are exceptional in immunocompetent patient. Healing is based on early diagnosis and administration of the reference antifungal to face the risk of recurrence.
Published: 2016

32. An Unusual Association: Triple X, 2Q Duplication, and Charge Syndrome

Author: Luigi Memo, S. Boni, C. Rossi, and V. Comito
Subjects: Genetics, Pediatrics, medicine.medical_specialty, CHARGE syndrome, business.industry, Association (object-oriented programming), Pediatrics, Perinatology and Child Health, Gene duplication, Obstetrics and Gynecology, Medicine, business, medicine.disease
Published: 2016
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33. [Indications and efficacy of intravitreal injections of anti-VEGF in black people in Abidjan]

Author: G Y, Ouffoue, S, Boni, L J K, Kouassi, A J, Konan, A O, Ouattara, T C, Sowagnon, E, Gombe, N W, Cheucheu, and A, Fanny
Subjects: Adult, Aged, 80 and over, Male, Diabetic Retinopathy, Patient Selection, Black People, Eye Diseases, Hereditary, Anemia, Sickle Cell, Light Coagulation, Middle Aged, Macular Edema, Bevacizumab, Cote d'Ivoire, Treatment Outcome, Intravitreal Injections, Humans, Female, Aged
Published: 2016

34. Measles Virus Glycoprotein-Pseudotyped Lentiviral Vectors Are Highly Superior to Vesicular Stomatitis Virus G Pseudotypes for Genetic Modification of Monocyte-Derived Dendritic Cells

Author: S. Boni, F. Halary, J.-M. Humbert, F. Amirache Bouafia, T. H. N′Guyen, Cecilia Frecha, Els Verhoeyen, and François-Loïc Cosset
Subjects: Cellular differentiation, Immunology, Genetic Vectors, Gene Expression, Receptors, Cell Surface, Biology, Microbiology, Resting Phase, Cell Cycle, Vesicular stomatitis Indiana virus, Measles virus, Membrane Cofactor Protein, 03 medical and health sciences, Transduction (genetics), Gene Delivery, 0302 clinical medicine, Immune system, Antigen, Viral Envelope Proteins, Transduction, Genetic, Virology, Humans, Lectins, C-Type, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, CD46, Lentivirus, Gene Transfer Techniques, Cell Differentiation, Dendritic Cells, biology.organism_classification, 3. Good health, Toll-Like Receptor 3, chemistry, Vesicular stomatitis virus, 030220 oncology & carcinogenesis, Insect Science, Glycoprotein, Cell Adhesion Molecules
Abstract: Dendritic cells (DCs) are potent antigen-presenting cells capable of promoting or regulating innate and adaptive immune responses against non-self antigens. To better understand the DC biology or to use them for immune intervention, a tremendous effort has been made to improve gene transfer in these cells. Lentiviral vectors (LVs) have conferred a huge advantage in that they can transduce nondividing cells such as human monocyte-derived DCs (MDDCs) but required high amounts of viral particles and/or accessory proteins such as Vpx or Vpr to achieve sufficient transduction rates. As a consequence, these LVs have been shown to cause dramatic functional modifications, such as the activation or maturation of transduced MDDCs. Taking advantage of new pseudotyped LVs, i.e., with envelope glycoproteins from the measles virus (MV), we demonstrate that MDDCs are transduced very efficiently with these new LVs compared to the classically used vesicular stomatitis virus G-pseudotyped LVs and thus allowed to achieve high transduction rates at relatively low multiplicities of infection. Moreover, in this experimental setting, no activation or maturation markers were upregulated, while MV-LV-transduced cells remained able to mature after an appropriate Toll-like receptor stimulation. We then demonstrate that our MV-pseudotyped LVs use DC-SIGN, CD46, and CD150/SLAM as receptors to transduce MDDCs. Altogether, our results show that MV-pseudotyped LVs provide the most accurate and simple viral method for efficiently transferring genes into MDDCs without affecting their activation and/or maturation status.
Published: 2012
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35. Spontaneous cutaneous umbilical endometriosis: a rare variant of extragenital endometriosis

Author: S. Boni, P. Guie, D.B. Mian, E. Nguessan, and K.L.P. Nguessan
Subjects: Reproductive Medicine, Obstetrics and Gynecology
Published: 2014
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36. Chirurgie de membrane épimaculaire en vitrectomie transconjonctivale 25-gauge : à propos de 50 cas

Author: S. Boni, G. Gendron, P.O. Barale, S.E. Scheer, F. Poisson, and J.A. Sahel
Subjects: Gynecology, Ophthalmology, medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine, Vitrectomy, business
Abstract: Resume Introduction La chirurgie de la membrane epimaculaire idiopathique a beneficie de l’avenement de la vitrectomie transconjonctivale (TSV) au 25-gauge, initiee par Fujii en 2002. Patients et methode Dans cette etude retrospective nous avons evalue notre experience portant sur 50 patients operes de membrane epimaculaire par TSV 25-gauge, au service IV Centre hospitalier national d’ophtalmologie des Quinze-Vingts a Paris de decembre 2004 a juin 2006. Resultats L’amelioration de l’acuite visuelle de loin et de pres etait statistiquement significative ; nous n’avons pas note d’endophtalmie postoperatoire, ni d’hypotonie majeure et de fuite des sclerotomies. Nous avons note deux cas (4 %) de decollement de retine et 47 % de cataracte a trois mois. Au troisieme mois, l’acuite visuelle s’etait significativement amelioree de loin et de pres. Conclusion La TSV 25-gauge a de nombreuses indications en chirurgie vitreoretinienne. Dans la chirurgie de la membrane epimaculaire, elle ne presente pas plus de complication que la vitrectomie 20-gauge. La TSV nous apparait comme une technique de choix pour l’ablation de la membrane epimaculaire.
Published: 2010
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37. Choriorétinopathie séreuse centrale : étude de 6 cas observés à Abidjan entre 2003 et 2005, rôle évoqué de la crise ivoirienne

Author: K. Gbe, F. Coulibaly, R. Bérété-Coulibaly, A. Fanny, M. Kéita, S. Boni, and A. Ouattara
Subjects: Pediatrics, medicine.medical_specialty, Black african, business.industry, Context (language use), Cote d ivoire, Ophthalmology, Serous fluid, Current practice, Medicine, Optometry, Anxiety, medicine.symptom, business, Psychosocial
Abstract: Central serous chorioretinopathy: a study of six cases observed in Abidjan between 2003 and 2005, suggesting a role played by the Ivorian political-military crisis A. Fanny, K. Gbe, F. Coulibaly, R. Berete-Coulibaly, S. BoniA.OuattaraM.Keita. Objective: This study aimed to show that central serous chorioretinopathy is present in Ivory Coast and that the emotional and psychosocial context plays an important role in this disorder’s pathogenesis. Patients and method: The authors report six central serous chorioretinopathy cases based on angiographic diagnosis, five in Black African subjects and one in a European subject. These cases were observed over a period of 2 years during the Ivorian political-military crisis. Results: In a center where angiography has been a current practice since 1999, up to 2002 479 angiographies were done without a single central serous chorioretinopathy case being diagnosed. After the beginning of the political-military crisis, six cases of central serous chorioretinopathy were observed out of 417 angiographies over a period of 2 years. All the patients were males, between 20 and 50 years old, five were Black Africans and one was a white European. Their professions varied (a contractor, a soldier, a business executive, for example). The angiography showed break points in ink spots in the majority of the cases, with one case showing multiple break points. All the patients were emotionally distraught because of the uncertainty of the political situation. Conclusion: This study confirms that central serous chorioretinopathy does indeed exist in the Black African subject, as it exists in the leucoderma subject without discrimination. This study emphasizes the anxiety and extreme emotional context as an initiating factor in the occurrence of central serous chorioretinopathy.
Published: 2008
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38. Lack of effect of repeated administration of tripelennamine on antipyrine disposition in camels

Author: A.A. Abdel Hadi, A. M. Al Muharami, I. M. Barezaig, N. A. Alkatheeri, N. S. Boni, I.A. Wasfi, and M. Elghazali
Subjects: Pharmacology, Veterinary medicine, General Veterinary, business.industry, Medicine, Disposition, business, Administration (government), Tripelennamine, medicine.drug
Published: 2008
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39. Épaisseur cornéenne centrale et erreur potentielle de la tonométrie à aplanation de Goldmann chez le patient noir africain atteint de glaucome primitif à angle ouvert

Author: R. Bérété-Coulibaly, M. Soumahoro, F. Coulibaly, K. Gbe, L. Nigué, A. Ouattara, A. Fanny, and S. Boni
Subjects: Applanation tonometry, Gynecology, Ophthalmology, medicine.medical_specialty, Black african, business.industry, Medicine, business, Goldmann applanation tonometry
Abstract: Epaisseur corneenne centrale et erreur potentielle de la tonometrie a aplanation de Goldmann chez le patient noir africain atteint de glaucome primitif a angle ouvert Introduction : La tonometrie a aplanissement de Goldmann est l’examen de reference pour la mesure de la pression intra-oculaire. Ce modele tonometrique est influence par l’epaisseur corneenne qui semble varier selon la race. La plupart des etudes sur l’epaisseur de la cornee ont ete realisees chez des patients caucasiens et noirs americains. Les etudes chez le patient Noir africain etant rares, le but de notre travail etait de mesurer l’epaisseur centrale de la cornee et d’evaluer son impact sur la tonometrie a aplanation de Goldmann chez le patient noir africain atteint de glaucome primitif a angle ouvert (GPAO). Patients et methode : Nous avons mene une etude retrospective sur des yeux de patients atteints de GPAO. L’epaisseur corneenne centrale a ete mesuree a l’aide d’un pachymetre ultrasonique (Quentel Medical). Resultats : Trois cent quarante yeux de 170 patients ont ete retenus. L’âge moyen des patients etait de 44,4 ± 12,7 ans. L’epaisseur corneenne centrale moyenne etait de 519,6 ± 32,6 µm, 57,6 % des patients ayant une epaisseur corneenne centrale inferieure a 527 µm, 30,6 %, une epaisseur comprise entre 527 et 560 µm, et 11,8 %, une epaisseur corneenne centrale superieure 560 µm. Discussion et conclusion : Compare au patient noir americain ou au patient caucasien, le patient glaucomateux Noir africain se distingue par la precocite du debut du glaucome et la minceur de la cornee. L’evaluation de l’epaisseur corneenne induit une erreur potentielle dans la mesure de la pression intra-oculaire chez le patient glaucomateux Noir africain. Ainsi, la tonometrie de Goldmann, chez le patient Noir africain, est sujette a un taux d’erreur estime a 69,4 % (57,6 % de sous-evaluation et 11,8 % de sur-evaluation). La pachymetrie est donc un examen complementaire necessaire chez le patient glaucomateux Noir Africain pour un ajustement de la PIO.
Published: 2008
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40. Bioavailability and hypoglycemic activity of the semisynthetic bile acid salt, sodium 3α,7α-dihydroxy-12-0X0-5β-cholanate, in healthy and diabetic rats

Author: Ksenija Kuhajda, Slavko Kevrešan, Hani Al-Salami, Svetlana Goločorbin-Kon, N. S. Boni, J. P. Fawcett, and Momir Mikov
Subjects: Pharmacology, Volume of distribution, medicine.medical_specialty, Bile acid, Chemistry, medicine.drug_class, Metabolite, Glucose transporter, medicine.disease, Bioavailability, chemistry.chemical_compound, Endocrinology, Pharmacokinetics, Oral administration, Diabetes mellitus, Internal medicine, medicine, Pharmacology (medical)
Abstract: Previous studies in our laboratory have shown that the semisynthetic bile acid derivative, sodium 3α,7α-dihydroxy-12-oxo-5β-cholanate (MKC), has hypoglycemic activity. The aim of this study was to investigate the relationship between the pharmacokinetics and hypoglycemic activity of MKC in healthy and diabetic rats. Groups of healthy and alloxan-induced diabetic rats were dosed intravenously (i.v.) and orally with MKC (4 mg/kg). Blood samples were taken before administration of the dose and at 20, 40, 60, 80, 120, 150, 180, 210 and 240 minutes post-dose. MKC serum concentration was measured by HPLC, and pharmacokinetic parameters determined using the WinNonlin program. The absolute bioavailability of MKC was found to be low in healthy and diabetic rats (29 and 23% respectively) and was not significantly different between the two groups. Mean residence time (MRT), volume of distribution (Vd) and half-life (t1/2) of MKC after oral administration were significantly lower in diabetic than in healthy rats (21, 31 and 29% respectively). After the i.v. dose, the change in blood glucose concentration was not significant in either healthy or diabetic rats. After the oral dose, the decrease in blood glucose concentration was significant, reaching a maximum decrease from baseline of 24% in healthy rats and 15% in diabetic rats. The results suggest that a first-pass effect is crucial for the hypoglycemic activity of MKC, indicating that a metabolite of MKC and/or interference with metabolism and glucose transport is responsible.
Published: 2007
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41. Valeurs biométriques de l’œil du sujet africain de race noire et hypothèse du rôle dans certaines pathologies

Author: S. Boni, A. Ouattara, K. Gbe, M. L. Konan-Toure, J. Aka, A. Fanny, F. Coulibaly, C. Adjorlolo, and R. Bérété-Coulibaly
Subjects: Ophthalmology
Abstract: Introduction La litterature internationale fait rarement allusion aux mensurations de l’œil du sujet africain de race noire. Aussi, les differents modeles dans lesquels les elements de biometrie sont utilises comme parametres meritent d’etre reconsideres car ils ne correspondent peut-etre pas reellement a l’œil du sujet de race noire de notre region. L’etude permet de disposer de mensurations vraies chez le sujet de race noire vivant en Cote d’Ivoire. Elle permet aussi d’emettre des hypotheses en extrapolant sur le role des mensurations dans des pathologies comme le glaucome. Materiel et methode L’etude a porte sur 325 yeux de 217 patients dont 104 hommes et 113 femmes. Tous les patients ont eu une keratometrie et une echobiometrie oculaire. La profondeur de la chambre anterieure, l’epaisseur du cristallin et la longueur axiale totale ont ete mesurees au biometre ultrascan par la methode de contact en echometrie A. Resultats La keratometrie moyenne est significativement plus elevee chez la femme (43,99 dioptries ± 1,62 contre 43,46 dioptries ± 1,45). La chambre anterieure est plus profonde chez l’homme (2,69 mm ± 0,54 contre 2,53 mm ± 0,48). L’œil de l’homme est plus long avec une longueur axiale de 23,26 mm ± 1,07 contre 22,56 mm ± 0,90. Conclusion L’etude montre une difference biometrique significative entre les yeux de l’homme et la femme d’une part, et d’autre part entre les yeux du sujet de race noire et celui de race blanche. Les raisons de ces differences sont multiples et pourraient etre d’ordre constitutionnel, socio-economique et technique (appareillage). Si l’on peut imaginer un implant standard de puissance differente entre le noir et le blanc, peut-on supposer de meme que la biometrie du sujet noir africain le predispose plus a une affection comme le glaucome ? Des etudes plus importantes pourraient repondre a cette question.
Published: 2007
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42. Late diagnosis of positive HIV serology in pregnancy incidentally discovered by the widespread appearance of Kaposi's sarcoma

Author: D B, Mian, C, Itoua, V, Angoi, E, Gbary, K L P, Nguessan, H, Iloki, and S, Boni
Subjects: Adult, Neoplasms, Multiple Primary, Delayed Diagnosis, Skin Neoplasms, Pregnancy, Humans, Female, HIV Infections, Pregnancy Complications, Infectious, Pregnancy Complications, Neoplastic, Sarcoma, Kaposi
Abstract: The authors report a case of Kaposi's sarcoma (KS) found in a pregnant woman. On discovery, the condition had spread throughout her body as is characteristic in some cases of individuals with HIV-positive serology. She was unaware of her HIV positive status. Her HIV infection had been diagnosed at the same time as KS at her last prenatal consultation. The newborn was delivered by an uncomplicated cesarean section. Appropriate treatment and multidisciplinary management after childbirth resulted in complete remission.
Published: 2015

43. Estimativa da excursão condilar em pacientes com disfunção craniomandibular: um enfoque multidisciplinar Estimate of condilar excursion in patients with craniomandibular dysfunction: a multidisciplinary approach

Author: Vanessa Cristina Aquotti Ilha, Abrão Rapoport, João Baptista Ilha Filho, Alessandra Aquotti Reis, and Alexandre S. Boni
Subjects: lcsh:RK1-715, Dysfunctions, Disfunções, lcsh:Dentistry, lcsh:R, lcsh:Medicine, Radiologia, Articulação temporomandibular, Radiology, Temporomandibular joint
Abstract: OBJETIVO: avaliar o padrão de excursão condilar em pacientes com disfunção craniomandibular. METODOLOGIA: a estimativa da excursão condilar da ATM foi estudada em 17 pacientes, 34 ATMs do Serviço de Cirurgia Bucomaxilofacial do Hospital Jaraguá-São Paulo/SP, todos com diagnóstico de disfunção craniomandibular. Foi utilizado o exame radiográfico do tipo transcraniano para verificar a estimativa da excursão condilar, bem como o índice de Helkimo, para classificar o grau de disfunção de cada paciente. As ATMs de cada paciente foram examinadas por três diferentes profissionais com auxílio do exame radiográfico. O exame clínico observou dados como raça, gênero, a queixa principal de cada paciente, presença de dor pré-auricular, dor muscular, estalo nas articulações e limitação da abertura da boca. RESULTADOS E CONCLUSÕES: a dor pré-auricular e os estalidos foram as principais queixas dos pacientes. A excursão condilar mais freqüente foi a normoexcursão, seguida da hiperexcursão, associada com o grau II de disfunção articular de Helkimo.AIM: to evaluate the condilar excursion pattern in patients presenting craniomandibular dysfunction. METHODS: the estimate of condilar excursion of TMJ were studied in 17 patients, 34 TMJs of the service of Hospital Jaraguá São Paulo/SP. All of them with diagnostic of craniomandibular dysfunction. It was used TMJ transcranial radiographs to verify the radiographics alterations and Helkimo index to classify the dysfunction degree of each patient. The TMJs of each patient were examined by three differents professionals with help of radiographics exams. The clinical examination searched to observe aspects as race, sex, age, the main complaint of each patient, presence of preauricular pain, muscular pain, articular cracks and limitation of mouth overture. RESULTS AND CONCLUSION: pre-auricular pain and articular clicks were the main complain among patients. The normo-excursion was more frequently found, followed by hiper-excursion, associated with Helkimos degree II.
Published: 2006

44. Efficacité et tolérance de l′huile de silicone lourde dans la chirurgie du décollement de rétine

Author: Laurent Laroche, Christophe Baudouin, S. Scheer, Ja Sahel, A. Bourhis, O. Buil, Jean-François Girmens, F. Poisson, E. Tuil, Jean-Philippe Nordmann, S. Bonnel, P O Barale, S. Boni, and Jean-Michel Warnet
Subjects: Gynecology, Ophthalmology, medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine, Follow up studies, Vitrectomy, business
Abstract: Objectif Evaluer la tolerance et l’efficacite de l’injection d’huile de silicone lourde comme tamponnement interne dans la chirurgie du decollement de retine. Patients et methodes Une etude retrospective a ete menee sur 66 yeux de 66 patients ayant eu une injection d’huile de silicone lourde pour decollement de retine, avec un suivi d’au minimum 1 mois. Les caracteristiques preoperatoires et la technique chirurgicale du decollement de retine ont ete evaluees, ainsi que la tolerance et les resultats anatomiques et fonctionnels. Les indications de l’injection de silicone lourde etaient une retinotomie inferieure ou une retraction inferieure dans 65 % des cas. Il existait une proliferation vitreo-retinienne (PVR) de stade C dans plus de 63 % des cas. Une retinotomie a ete realisee dans 42 % des cas. L’injection d’huile de silicone lourde etait effectuee versus DK-line dans 65 % des cas. Le suivi moyen etait de 7 p 4 mois. Resultats En fin de suivi, 59 % des patients avaient une retine a plat, 32 % sans tamponnement interne. Au moins une chirurgie retinienne supplementaire a ete necessaire dans 54 % des cas. Tout au long du suivi, la pression intra-oculaire moyenne a ete normale. Trois cas (4,5 %) d’inflammation oculaire severe ont ete constates. L’adherence de bulles residuelles a divers tissus oculaires a ete notee dans 7 sur 44 ablations d’huile de silicone lourde. Une recidive apres ablation a eu lieu dans 41 % des cas. L’acuite visuelle etait superieure a 1/20e dans 54 % des cas en fin de suivi. Conclusion L’huile de silicone lourde est une bonne alternative a l’huile de silicone standard dans les retinotomies inferieures ou les lesions inferieures sans retraction. Elle est bien toleree et ne semble pas pro inflammatoire. Elle n’est pas un traitement de la retraction inferieure et ne doit pas etre consideree comme un tamponnement interne de longue duree. Le risque d’adherence de bulles residuelles necessite d’utiliser un eclairage coaxial ou une endolumiere lors de l’ablation.
Published: 2006
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45. Enhancing disaster risk resilience using greenspace in urbanising Quito, Ecuador

Author: C. S. Watson, J. R. Elliott, S. K. Ebmeier, M. A. Vásquez, C. Zapata, S. Bonilla-Bedoya, P. Cubillo, D. F. Orbe, M. Córdova, J. Menoscal, and E. Sevilla
Subjects: Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: Greenspaces within broader ecosystem-based disaster risk reduction (Eco-DRR) strategies provide multiple benefits to society, biodiversity, and addressing climate breakdown. In this study, we investigated urban growth, its intersection with hazards, and the availability of greenspace for disaster risk reduction (DRR) in the city of Quito, Ecuador, which experiences multiple hazards including landslides, floods, volcanoes, and earthquakes. We used satellite data to quantify urban sprawl and developed a workflow incorporating high-resolution digital elevation models (DEMs) to identify potential greenspaces for emergency refuge accommodation (DRR greenspace), for example, following an earthquake. Quito's historical urban growth totalled ∼ 192 km2 for 1986–2020 and was primarily on flatter land, in some cases crossed by steep ravines. By contrast, future projections indicate an increasing intersection between easterly urbanisation and steep areas of high landslide susceptibility. Therefore, a timely opportunity exists for future risk-informed planning. Our workflow identified 18.6 km2 of DRR greenspaces, of which 16.3 km2 intersected with potential sources of landslide and flood hazards, indicating that hazard events could impact potential “safe spaces”. These spaces could mitigate future risk if designated as greenspaces and left undeveloped. DRR greenspace overlapped 7 % (2.5 km2) with municipality-designated greenspace. Similarly, 10 % (1.7 km2) of municipality-designated “safe space” for use following an earthquake was classified as potentially DRR suitable in our analysis. For emergency refuge, currently designated greenspaces could accommodate ∼ 2 %–14 % (depending on space requirements) of Quito's population within 800 m. This increases to 8 %–40 % considering all the potential DRR greenspace mapped in this study. Therefore, a gap exists between the provision of DRR and designated greenspace. Within Quito, we found a disparity between access to greenspaces across socio-economic groups, with lower income groups having less access and further to travel to designated greenspaces. Notably, the accessibility of greenspaces was high overall with 98 % (2.3 million) of Quito's population within 800 m of a designated greenspace, of which 88 % (2.1 million) had access to potential DRR greenspaces. Our workflow demonstrates a citywide evaluation of DRR greenspace potential and provides the foundation upon which to evaluate these spaces with local stakeholders. Promoting equitable access to greenspaces, communicating their multiple benefits, and considering their use to restrict propagating development into hazardous areas are key themes that emerge for further investigation.
Published: 2022
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46. Les bêtathalasso-drépanocytoses pourvoyeuses de rétinopathies ischémiques graves

Author: M. L. Konan-Toure, C. Adjorlolo, F. Coulibaly, R. Berete, A. Ouattara, K. Gbe, M. Meite, A. Fanny, S. Boni, and Mamadou Alpha Diallo
Subjects: Gynecology, Hemolytic anemia, Ophthalmology, medicine.medical_specialty, Hemoglobinopathy, business.industry, medicine, Sickle cell retinopathy, medicine.disease, business, Sickle cell anemia, Retinopathy
Abstract: Le but de cette etude est de demontrer que les betathalasso-drepanocytoses font courir des risques importants d’hemorragie oculaire, au meme titre que les formes SC. Les deux formes seraient d’ailleurs comparables du fait du risque de necrose aseptique de la tete femorale. Sur les 18 patients inclus dans cette etude, 13 cas (72,2 %) presentaient une retinopathie drepanocytaire. Trois de ces patients avaient deja developpe des neovaisseaux et risquaient une hemorragie intravitreenne. En conclusion, les auteurs recommandent que les betathalasso-drepanocytoses fassent l’objet d’une plus grande vigilance et d’un suivi ophtalmologique plus rigoureux et systematique ainsi que d’un traitement precoce. Le traitement par photocoagulation retinienne au laser Argon est efficace seulement si le diagnostic est effectif et precoce.
Published: 2005
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47. La rétinopathie chez le porteur du trait drépanocytaire AS : mythe ou réalité ?

Author: R. Berete, C. Adjorlolo, F. Coulibaly, A. Fany, S. Boni, M.L. Toure Konan, and K. Gbe
Subjects: Gynecology, Ophthalmology, medicine.medical_specialty, business.industry, medicine, business
Abstract: Introduction La retinopathie drepanocytaire est une retinopathie ischemique frequente dans les formes drepanocytaires majeures SS et SC. La retinopathie du trait drepanocytaire AS etant peu decrite dans la litterature, sa realite est remise en cause. Patients et methode Cette etude s’est fixe pour objectif de contribuer a une meilleure connaissance de cette pathologie, a travers un examen clinique et angiographique de 75 patients porteurs du trait drepanocytaire AS. Resultats Soixante-douze pour cent de cet effectif avait des lesions retiniennes avec 49,3 % de lesions non-proliferatives contre 22,7 % de lesions pre-proliferatives et 2,7 % de neovaisseaux. Discussion et conclusion Il existe une retinopathie en rapport avec le trait drepanocytaire AS. Elle est moins importante et moins grave que celle retrouvee dans les formes drepanocytaires majeures.
Published: 2004
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48. Natural Honey Lowers Plasma Prostaglandin Concentrations in Normal Individuals

Author: Nader S. Boni and Noori S. Al-Waili
Subjects: Adult, Male, medicine.medical_specialty, Thromboxane, medicine.medical_treatment, Medicine (miscellaneous), Prostaglandin, Enzyme-Linked Immunosorbent Assay, Dinoprost, Body weight, chemistry.chemical_compound, Internal medicine, Humans, Medicine, Ingestion, Morning, Nutrition and Dietetics, business.industry, Prostaglandins E, Fasting, Honey, Middle Aged, Thromboxane B2, Kinetics, Endocrinology, chemistry, Plasma concentration, Prostaglandins, Female, lipids (amino acids, peptides, and proteins), business, Quantitative analysis (chemistry), Prostaglandin E
Abstract: Twelve normal, healthy adult individuals, 9 men and 3 women, 25-48 years of age (mean, 38 years), were recruited in the study. After 12 hours of fasting, blood specimens were collected at 8:00 AM for prostaglandin E(2) (PGE(2)), PGF(2alpha), and thromboxane B(2) assays. Each individual then drank 250 ml of water containing 1.2 g/kg body weight of natural unprocessed honey, after which collection of blood was repeated at 1, 2, and 3 hours for estimation of prostaglandins. Each individual was asked to drink the same amount of honey diluted in water once a day for a maximum of 15 days. After 12 hours of fasting, morning blood specimens were collected on day 16, and plasma prostaglandin concentrations were measured. The quantitative analysis of prostaglandins was performed with use of an enzyme-linked immunosorbent (ELISA) test. Results showed that the mean plasma concentration of thromboxane B(2) was reduced by 7%, 34%, and 35%, and that of PGE(2) by 14%, 10%, and 19%, at 1, 2, and 3 hours, respectively, after honey ingestion. The level of PGF(2alpha) was decreased by 31% at 2 hours and 14% at 3 hours after honey ingestion. At day 15, plasma concentrations of thromboxane B(2), PGE(2), and PGF(2a) were decreased by 48%, 63%, and 50%, respectively. It may be concluded that honey can lower the concentrations of prostaglandins in plasma of normal individuals.
Published: 2003
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49. The influence of social networks on unusual sexual practices and the related health impact

Author: S Boni, S Barbieri, P Frisoni, S Benedetti, R Snenghi, M Bergamini, G Vettore, L Omizzolo, FM Avato, P Feltracco, and RM Gaudio
Subjects: Dominance and Submission, Bondage and Discipline, Dominance and Submission, Sadism and Masochism, Sadism and Masochism, Bondage and Discipline, Public Health, Environmental and Occupational Health, NO
Published: 2015

50. Spontaneous cutaneous umbilical endometriosis: a rare variant of extragenital endometriosis

Author: K L P, Nguessan, E, Nguessan, D B, Mian, P, Guie, and S, Boni
Subjects: Adult, Umbilicus, Endometriosis, Humans, Female, Skin Diseases
Abstract: Umbilical endometriosis is a very uncommon condition which presents as a pigmented umbilical nodule, papular or cystic, with symptoms punctuated rhythmed by menses. The authors report the case of a 32-year-old with spontaneous umbilical endometriosis. Surgical resection was performed with a good cosmetic result and no recurrence at six months. A review of the literature allowed the authors to discuss the diagnosis difficulties and treatment in a underdeveloped country.
Published: 2014

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