26 results on '"S. Betrian"'
Search Results
2. 301 Management of patients with advanced stage epithelial ovarian cancer: results of a national french survey on current practices in 2021
- Author
-
Benedetta Guani, Cherif Akladios, François Zaccarini, Vincent Balaya, S Bendifallah, Claire Sanson, Yohan Kerbage, F Guyon, S Betrian, Yohann Dabi, Elise Deluche, Pierre-Adrien Bolze, Patrice Mathevet, Fabrice Lecuru, L Drouin, and Henri Azaïs
- Subjects
medicine.medical_specialty ,Bevacizumab ,business.industry ,General surgery ,BRCA mutation ,Cancer ,medicine.disease ,Debulking ,Olaparib ,Clinical trial ,chemistry.chemical_compound ,chemistry ,medicine ,Hyperthermic intraperitoneal chemotherapy ,business ,Ovarian cancer ,medicine.drug - Abstract
Introduction/Background* The management of ovarian cancer has rapidly become more complex in recent years due to surgical and medical advances. The aim of this study was to assess French current practice in management of patients with advanced epithelial ovarian cancer. Methodology An anonymous survey was sent to the SFOG, GINECO-ARCAGY and FRANCOGYN members. The survey consisted of 58 items divided in five sections dealing with diagnostic staging, pathological and genetic data, surgical practice patterns, adjuvant/neoadjuvant treatment, and follow-up strategies. Result(s)* Overall, 107 answers were available. Most of participants were obstetrician-gynecologists (37.4%), surgical oncologists (34.6%), and medical oncologists (17.8%). Most of participants came from University Hospitals (40.2%) and Comprehensive Cancer Center (37.4%). For 76.8% of respondents, less than 50% of patients are eligible for primary debulking surgery. In case of neoadjuvant chemotherapy, surgical resecability is assessed after 3 cycles for 92.7% of respondents. LION study’s criteria were always applied during primary surgery for 69,5% of respondents. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is used as a first-line treatment for 41.4% of respondents (26.8% within clinical trial and 14.6% outside) and during interval surgery for 37.8% of respondents. According to the completeness of cytoreduction surgery and the BRCA mutation status, association of Paclitaxel-Carboplatin (every 3 weeks) is the most used combination as adjuvant chemotherapy for 69.7 to 84.8% of respondents and bevacizumab 15mg/kg is used in case of no residual disease for 52.9 to 61.7 of respondents. In case of BRCA1-2 mutations, Olaparib is given by 75.8% to 84.8% of respondents. The delay to obtain BRCA germline mutation results is less than 1 month for 26.5% of respondents and less than 3 months for 76.5% of respondents. An Homologous Recombination Repair Deficiency is searched for 73.5% of respondents and mainly by Myriad test (91.3%). Conclusion* In our study, the rate of HIPEC was high because 2 clinical trials are currently ongoing in France on HIPEC as 1st line treatment. Our results provide an interesting picture of current management in France in relation to International Guidelines. They provide a basis for further research and raise the question of updating guidelines for ovarian cancer management.
- Published
- 2021
3. 662 An international survey of practice patterns in ovarian cancer: what we stand for in 2021
- Author
-
Elise Deluche, Henri Azaïs, Cherif Akladios, Pierre-Adrien Bolze, François Zaccarini, Vincent Balaya, Yohan Kerbage, F Guyon, Fabrice Lecuru, Patrice Mathevet, HC Hsu, L Drouin, S Betrian, Yohann Dabi, S Bendifallah, Benedetta Guani, Claire Sanson, and T Nikolova
- Subjects
medicine.medical_specialty ,Carcinosis ,Bevacizumab ,business.industry ,General surgery ,BRCA mutation ,Debulking ,medicine.disease ,Olaparib ,Clinical trial ,chemistry.chemical_compound ,chemistry ,Medicine ,Hyperthermic intraperitoneal chemotherapy ,business ,Ovarian cancer ,medicine.drug - Abstract
Introduction/Background* The aim of this study was to investigate the current surgical and non-surgical therapeutic management of advanced epithelial ovarian cancer (AEOC) cases worldwide, using the data from an internationally launched survey. Methodology After the validation of a 58-item survey regarding diagnostic and pathological data, as well as surgical and chemotherapeutic strategies of AEOC in France, in the period between April and May 2021, the survey was launched among the members of the following gynecological cancer societies and study groups: IJGC Fellows, SENTICOL 3 study group, ARCAGY-GINECO, AGO, SFOG, SFOG Campus and FRANCOGYN. Result(s)* A total of 203 physicians completed the survey and majority of them, 171 (84.7%) were from Europe. Gynecological oncologists represented 49.2% of the respondents, surgical oncologists 25.1% and medical oncologists 13.7%. Most of the participants work in centers, managing more than 20 AEOC per year (91.5%). According to 66.7% of respondents, less than 50% of patients were eligible for primary debulking surgery (PDS). If neoadjuvant chemotherapy (NACT) was used, resectability was assessed after 3 cycles of NACT before interval debulking surgery (IDS) was performed. The most used peritoneal carcinomatosis index was Sugarbaker (69.8%), whereas Fagotti, modified Fagotti and Makar scores were used in 35.4%, 20.1% and 4.9%, respectively. After the initial staging, the decision between PDS and NADS-IDS was based on the number of the surgical procedures which had to be performed (82.9%), carcinosis index (61.6%), patient’s age (51.2%), global visual assessment (36.0%) and surgeon’s personal estimation (11.0%). During IDS, LION study’s criteria were always applied according to only 23.1% of the respondents. Hyperthermic intraperitoneal chemotherapy (HIPEC) was used as a first-line treatment from 16.0% of respondents within clinical trials and 14.1% out of clinical trials. Regardless of the surgical strategy (PDS or NACT-IDS) and the completeness of cytoreduction surgery, Olaparib was prescribed by 74.3% to 81.4% of the respondents and Niraparib by 8.6% to 12.9%. Bevacizumab was prescribed by 42.9% to 68.6% in case of no BRCA mutation. Conclusion* According to our study, the current management of ovarian cancer is in line with the ESGO guidelines. More participants are necessary for a more precise presentation.
- Published
- 2021
4. 819TiP COLIBRI trial (GINECO-CE108b): A multicenter, window study evaluating immune impact and safety of nivolumab in combination with ipilimumab before initial radio-chemotherapy (RTCT) treatment for locally advanced cervix cancer
- Author
-
A.M. Savoye, Christophe Caux, M.A. Mouret Reynier, Florence Joly, Elise Deluche, Pierre Saintigny, I.L. Ray-Coquard, D. Bello Roufai, Isabelle Treilleux, A-C. Hardy-Bessard, H. Péré, Antoine Angelergues, Fabrice Lecuru, S Betrian, M-C. Kaminsky-Forrett, and L. Montané
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Locally advanced ,Cancer ,Ipilimumab ,Hematology ,medicine.disease ,Immune system ,medicine.anatomical_structure ,Internal medicine ,medicine ,Nivolumab ,business ,Cervix ,medicine.drug ,Radio chemotherapy - Published
- 2021
5. Risk factors for bleeding, including platelet count threshold, in newly diagnosed immune thrombocytopenia adults
- Author
-
M.‐L. Piel‐Julian, M. Mahévas, J. Germain, L. Languille, T. Comont, M. Lapeyre‐Mestre, B. Payrastre, O. Beyne‐Rauzy, M. Michel, B. Godeau, D. Adoue, G. Moulis, L. Alric, S. Arista, L. Astudillo, L. Balardy, S. Betrian, D. Bonnet, C. Borel, D. Brechemier, N. Brun, M. Carreiro, B. Castel, L. Caudrelier, P. Cougoul, A. Danu, K. Delavigne, C. Dingremont, T. Faurie, F. Gaches, M.‐H. Gaspard, C. Gaudin, A. Godel‐Labouret, P. Giraud, S. Hadj‐Khelifa, B. Hebraud, S. Khatibi, L. Leplay, Y. Leveneur, N. Limal, S. Ollier, S. Madaule, B. Marchou, C. Martel, G. Martin‐Blondel, P. Montane De La Roque, M. Michaud, J. Moeglin, F. Nuccio, L. Prudhomme, G. Pugnet, C. Recher, V. Remy, L. Sailler, S. Sire, A. Sommet, S. Tavitian, M.‐F. Thiercelin‐Legrand, W. Vaillant, Centre hospitalier universitaire de Toulouse-Purpan, CHU Henri Mondor, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM, Service de Pharmacologie Médicale et Clinique, CHU Toulouse [Toulouse]-Centre d'Investigation Clinique, INSERM U1048 (I2CM), CHU de Toulouse, Laboratoire d'Hématologie, CHU Toulouse [Toulouse], Pagès, Nathalie, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Pharmacologie Clinique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Hématologie - IUCT-Oncopole [CHU Toulouse], Pôle Biologie [CHU Toulouse], and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT [CHU Toulouse]
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multivariate analysis ,[SDV]Life Sciences [q-bio] ,Newly diagnosed ,Comorbidity ,030204 cardiovascular system & hematology ,Logistic regression ,Gastroenterology ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,Internal medicine ,Epidemiology ,Medicine ,Humans ,risk factors ,Platelet ,Mucosal bleeding ,Aged ,Aged, 80 and over ,Purpura, Thrombocytopenic, Idiopathic ,Receiver operating characteristic ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Anticoagulants ,Hematology ,Middle Aged ,platelet count ,Immune thrombocytopenia ,3. Good health ,[SDV] Life Sciences [q-bio] ,Cross-Sectional Studies ,idiopathic thrombocytopenic purpura ,ROC Curve ,030220 oncology & carcinogenesis ,Area Under Curve ,Female ,epidemiology ,hemorrhage ,business ,Selective Serotonin Reuptake Inhibitors - Abstract
International audience; Essentials Risk factors of bleeding in adult immune thrombocytopenia are not known. This multicenter study assessed risk factors of bleeding at immune thrombocytopenia onset. Platelet count thresholds associated with bleeding were < 20 × 109 L-1 and < 10 × 109 L-1 . Exposure to anticoagulants was a major risk factor of severe bleeding.Summary: Background The aim of this cross-sectional study was to assess risk factors for bleeding in immune thrombocytopenia (ITP) adults, including the determination of platelet count thresholds. Methods We selected all newly diagnosed ITP adults included in the Cytopénies Auto-immunes Registre Midi-PyrénéEN (CARMEN) register and at the French referral center for autoimmune cytopenias. The frequencies of any bleeding, mucosal bleeding and severe bleeding (gastrointestinal, intracranial, or macroscopic hematuria) at ITP onset were assessed. Platelet count thresholds were assessed by the use of receiver operating characteristic curves. All potential risk factors were included in logistic regression models. Results Among the 302 patients, the frequencies of any, mucosal and severe bleeding were 57.9%, 30.1%, and 6.6%, respectively. The best discriminant threshold of platelet count for any bleeding was 20 × 109 L-1 . In multivariate analysis, factors associated with any bleeding were platelet count (< 10 × 109 L-1 versus ≥ 20 × 109 L-1 , odds ratio [OR] 48.2, 95% confidence interval [CI] 20.0-116.3; between 10 × 109 L-1 and 19 × 109 L-1 versus ≥ 20 × 109 L-1 , OR 5.2, 95% CI 2.3-11.6), female sex (OR 2.6, 95% CI 1.3-5.0), and exposure to non-steroidal anti-inflammatory drugs (NSAIDs) (OR 4.8, 95% CI 1.1-20.7). A low platelet count was also the main risk factor for mucosal bleeding. Exposure to anticoagulant drugs was associated with severe bleeding (OR 4.3, 95% CI 1.3-14.1). Conclusions Platelet counts of < 20 × 109 L-1 and < 10 × 109 L-1 were thresholds for major increased risks of any and mucosal bleeding. Platelet count, female sex and exposure to NSAIDs should be considered for assessment of the risk of any bleeding. Exposure to anticoagulant drugs was a major risk factor for severe bleeding.
- Published
- 2018
6. Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant /relapse-initiating CLL cells: a rationale for combination treatment
- Author
-
K H Heider, Anne Quillet-Mary, J P Delord, Loic Ysebaert, Jean-Jacques Fournié, S Betrian, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut Claudius Regaud
- Subjects
0301 basic medicine ,[SDV]Life Sciences [q-bio] ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,CD37 ,Pharmacology ,03 medical and health sciences ,Preclinical research ,0302 clinical medicine ,Combined treatment ,hemic and lymphatic diseases ,Medicine ,Cytotoxicity ,neoplasms ,Letter to the Editor ,ComputingMilieux_MISCELLANEOUS ,biology ,business.industry ,Hematology ,3. Good health ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Antibody ,business ,Idelalisib - Abstract
Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant /relapse-initiating CLL cells: a rationale for combination treatment
- Published
- 2016
7. Une thrombopénie immunologique sévère secondaire au sunitinib : une association rare
- Author
-
C. Nozal, P. Cougoul, Odile Beyne-Rauzy, Thibault Comont, S. Betrian, K. Delavigne, M. Picard, C. Nivet, M. Lemeu, and J. Maquet
- Subjects
Gastroenterology ,Internal Medicine - Abstract
Introduction Le sunitinib est un inhibiteur de recepteur de tyrosine kinase (ITK) approuve dans le traitement des cancers metastatiques renaux, des tumeurs stromales digestives et des tumeurs neuroendocrines pancreatique. Les effets secondaires hematologiques classiquement decrits (neutropenie, thrombopenie) sont habituellement d’origine toxique. Seuls quelques cas publies decrivent la survenue de thrombopenie immunologique (PTI) mais aucune a notre connaissance de situation severe persistante necessitant une escalade therapeutique. Observation Une patiente de 62 ans suivie pour un adenocarcinome renal en situation metastatique est prise en charge pour une thrombopenie aigue symptomatique. La neoplasie a ete diagnostiquee en 2009, avec nephrectomie initiale. Plusieurs reprises evolutives a distance sont constatees au cours du suivi (rachidiennes, loge de nephrectomie) necessitant de nouvelles interventions therapeutiques (reprises chirurgicales, radiotherapie). Devant une nouvelle evolutivite au niveau de la loge de nephrectomie loge de nephrectomie en 2017, un traitement par est debute sunitinib le 14 decembre 2017. Le 6 janvier 2018, elle est hospitalise pour l’apparition d’un purpura petechial cutane et muqueux (voile du palais) revelant une thrombopenie a 2 G/L (plaquettes normales le 07/12/2017). Le tableau se complique rapidement de rectorragies massives avec deglobulisation ne repondant pas aux transfusions plaquettaires. L’ensemble du bilan etiologique recommande par le protocole national de diagnostic et de soins sur le PTI est negatif. Le myelogramme est en faveur d’une origine peripherique sans anomalie cytologique. Nous retenons un effet secondaire du sunitinib. Elle beneficie d’une prise en charge reanimatoire (remplissage, transfusions globulaires) ainsi que de l’initiation d’une corticotherapie intra veineuse a la posologie de 1 mg/kg/j (j1 le 06/01/2018) associee a une cure d’immunoglobulines (IgIV) a la dose totale de 2 g/kg (j1 08/01). Ce traitement de premiere intention est inefficace avec persistance des saignements. Elle recoit une perfusion de Vinblastine (8 mg) le 11/01 puis finalement d’un traitement par romiplostim a la dose 10 μg/kg le 14/01 repetee a j7 a dose identique. En parallele, elle recoit des soutiens transfusionnels plaquettaires pluriquotidiens. A partir du 21/01, le syndrome hemorragique disparait, et le taux plaquettaire passe au-dessus de 30 G/L puis de 100 G/L respectivement les 21 et 23/01/2018. Le sunitinib a ete arrete a l’occasion de l’apparition du syndrome hemorragique et ne sera pas repris dans les suites. Conclusion Nous decrivons donc le cas d’un PTI associe a des manifestions hemorragiques graves secondaire a l’utilisation du sunitinib. Deux originalites dans cette observation : la premiere reside en la gravite du tableau clinique et a la necessite de recourir a des therapeutique de seconde intention ; la deuxieme tient a la persistance de la thrombopenie a distance de l’arret du sunitinib. Cette observation pose la question du mecanisme immunologique implique. En effet, le sunitinib est un ITK qui cible le VEGF2 et le PDGFR-beta. D’autres manifestations auto-immunes ont ete rapportees avec ce medicament (dysthyroidie) ce qui laisse penser a une action sur le systeme immunitaire en plus de son action vasculaire.
- Published
- 2018
8. Intraepithelial tumor-infiltrating lymphocytes shape loco-regional PET/CT spread of locally advanced cervical cancer.
- Author
-
Del M, Illac C, Morisseau M, Angeles MA, Ducassou A, Betrian S, Bataillon G, Ferron G, Chantalat E, Gabiache E, and Martinez A
- Subjects
- Humans, Female, Positron Emission Tomography Computed Tomography, Lymphocytes, Tumor-Infiltrating, Positron-Emission Tomography, Lymph Nodes pathology, Retrospective Studies, Fluorodeoxyglucose F18, Radiopharmaceuticals, Tumor Microenvironment, Uterine Cervical Neoplasms diagnostic imaging, Uterine Cervical Neoplasms therapy, Uterine Cervical Neoplasms metabolism, Genital Neoplasms, Female pathology
- Abstract
Background: Data suggest an association between positron emission tomography/CT (PET/CT) metabolic metrics and tumor microenvironment in several malignancies, and a potential role of PET/CT to monitor response to immunotherapy., Objective: To evaluate the correlation between tumor loco-regional extension and tumor-infiltrating lymphocyte infiltration in locally advanced cervical cancer prior to concurrent chemo-radiotherapy.The secondary objective was to assess the association between tumor-infiltrating lymphocytes and PET/CT metabolic metrics., Methods: Patients with locally advanced cervical cancer and negative para-aortic extensions on PET/CT were included. Two senior nuclear medicine physicians specializing in gynecologic oncology reviewed all PET/CT exams, and extracted tumor maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis, as well as pelvic lymph node involvement. One senior gynecologic oncology pathologist assessed intraepithelial tumor-infiltrating lymphocytes and stromal tumor-infiltrating lymphocytes. Intraepithelial tumor-infiltrating lymphocytes were categorized following previous studies as <1% and >1%. The cut-off for stromal tumor-infiltrating lymphocytes was chosen empirically: intermediate <60% and high >60%., Results: 86 patients were included. Intraepithelial tumor-infiltrating lymphocytes were not significantly associated with tumor metabolic metrics. Intraepithelial tumor-infiltrating lymphocytes were not significantly associated with maximum standard uptake value (p=0.16), or metabolic tumor volume (p=0.19). Tumors with <1% intraepithelial tumor-infiltrating lymphocytes score were associated with a higher MRI tumor size (≥ median) (63.3% vs 39.3%, p=0.04). Patients with pelvic lymph node uptake were significantly more frequent in patients with high stromal tumor-infiltrating lymphocytes score (≥60%) (61.5% vs 31.7%, p=0.009)., Conclusions: Poor or absent intraepithelial tumor-infiltrating lymphocytes were associated with more advanced disease at diagnosis and larger tumor size. Tumor-infiltrating lymphocytes were not associated with tumor metabolic activity. Intraepithelial and stroma tumor-infiltrating lymphocytes are not redundant and should be assessed separately. Further work is needed to evaluate the association between tumor metabolic profile and immune populations, including different T-cell subtypes for patient selection for immunotherapy strategies., Competing Interests: Competing interests: None declared., (© IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
- Full Text
- View/download PDF
9. Management of patients with advanced epithelial ovarian cancer: a European survey.
- Author
-
Jochum F, Angeles MA, Balaya V, Drouin L, Nikolova T, Mathevet P, Lécuru F, Azais H, Betrian S, Bolze PA, Dabi Y, Kerbage Y, Sanson C, Zaccarini F, Guyon F, Akladios C, Hsu A, Bendifallah S, Deluche E, and Guani B
- Subjects
- Humans, Female, Carcinoma, Ovarian Epithelial therapy, Carcinoma, Ovarian Epithelial pathology, Surveys and Questionnaires, Europe, Neoplasm Staging, Cytoreduction Surgical Procedures, Neoadjuvant Therapy, Ovarian Neoplasms surgery, Ovarian Neoplasms drug therapy
- Abstract
Background: The aim of this study was to assess current European practices in the management of patients with advanced epithelial ovarian cancer in 2021., Methods: A 58-question electronic survey was distributed anonymously to the members of six European learned societies. Initial diagnostic workup and staging, pathological data, surgical data, treatments and follow-up strategies were assessed., Results: A total of 171 participants from 17 European countries responded to emailed surveys. Most participants were experienced practitioners (superior than 15 years of experience) specializing in gynecology-obstetrics (29.8%), surgical oncology (25.1%), and oncogynecology (21.6%). According to most (64.8%) participants, less than 50% of patients were eligible for primary debulking surgery. Variations in the rate of primary debulking surgery depending on the country of origin of the practitioners were observed in this study. The LION study criteria were applied in 70.4% of cases during PDS and 27.1% after chemotherapy. In cases of BRCA1-2 mutations, olaparib was given by 75.0-84.8% of respondents, whereas niraparib was given in cases of BRCA wild-type diseases., Conclusions: This study sheds light on current practices and attitudes regarding the management of patients with advanced epithelial ovarian cancer in Europe in 2021., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
10. A Phase II Redifferentiation Trial with Dabrafenib-Trametinib and 131I in Metastatic Radioactive Iodine Refractory BRAF p.V600E-Mutated Differentiated Thyroid Cancer.
- Author
-
Leboulleux S, Do Cao C, Zerdoud S, Attard M, Bournaud C, Lacroix L, Benisvy D, Taïeb D, Bardet S, Terroir-Cassou-Mounat M, Anizan N, Bouvier-Morel E, Lamartina L, Lion G, Betrian S, Sajous C, Schiazza A, Garcia ME, Ciappuccini R, Schlumberger M, Al Ghuzlan A, Godbert Y, and Borget I
- Subjects
- Humans, Iodine Radioisotopes adverse effects, Proto-Oncogene Proteins B-raf genetics, Prospective Studies, Pyridones adverse effects, Pyrimidinones, Oximes adverse effects, Antineoplastic Combined Chemotherapy Protocols adverse effects, Mutation, Thyroid Neoplasms drug therapy, Thyroid Neoplasms genetics, Thyrotropin Alfa, Adenocarcinoma etiology
- Abstract
Purpose: To evaluate the efficacy and safety of dabrafenib-trametinib-131I for the treatment of radioactive iodine refractory metastatic differentiated thyroid cancer (DTC) with a BRAF p.V600E mutation., Patients and Methods: A prospective phase II trial including patients with RECIST progression within 18 months and no lesion > 3 cm. Following a baseline recombinant human (rh)TSH-stimulated diagnostic whole-body scan (dc1-WBS), dabrafenib and trametinib were given for 42 days. A second rhTSH-stimulated dc WBS (dc2-WBS) was done at day 28 and 131I (5.5 GBq-150 mCi after rhTSH) was administered at day 35. Primary endpoint was the 6-month RECIST objective response rate. In case of partial response (PR) at 6 or 12 months, a second treatment course could be given. Among 24 enrolled patients, 21 were evaluable at 6 months., Results: Abnormal 131I uptake was present on 5%, 65%, and 95% of the dc1-WBS, dc2-WBS, and post-therapy scans, respectively. At 6 months, PR was achieved in 38%, stable disease in 52%, and progressive disease (PD) in 10%. Ten patients received a second treatment course: one complete response and 6 PRs were observed at 6 months. The median progression-free survival (PFS) was not reached. The 12- and 24-month PFS were 82% and 68%, respectively. One death due to PD occurred at 24 months. Adverse events (AE) occurred in 96% of the patients, with 10 grade 3-4 AEs in 7 patients., Conclusions: Dabrafenib-trametinib is effective in BRAF p.V600E-mutated DTC patients for restoring 131I uptake with PR observed 6 months after 131I administration in 38% of the patients., (©2023 American Association for Cancer Research.)
- Published
- 2023
- Full Text
- View/download PDF
11. PARa-aOrtic LymphAdenectomy in locally advanced cervical cancer (PAROLA trial): a GINECO, ENGOT, and GCIG study.
- Author
-
Martinez A, Lecuru F, Bizzarri N, Chargari C, Ducassou A, Fagotti A, Fanfani F, Scambia G, Cibula D, Díaz-Feijoo B, Gil Moreno A, Angeles MA, Muallem MZ, Kohler C, Luyckx M, Kridelka F, Rychlik A, Gerestein KG, Heinzelmann V, Ramirez PT, Frumovitz M, Ferron G, Betrian S, Filleron T, Fotopoulou C, and Querleu D
- Subjects
- Female, Humans, Lymphatic Metastasis pathology, Neoplasm Recurrence, Local pathology, Lymph Node Excision methods, Lymph Nodes surgery, Lymph Nodes pathology, Neoplasm Staging, Retrospective Studies, Positron Emission Tomography Computed Tomography, Uterine Cervical Neoplasms surgery, Uterine Cervical Neoplasms pathology
- Abstract
Background: Positron emission tomography/computed tomography (PET/CT) fails to detect approximately 25% of aortic lymph node metastasis in patients with PET/CT stage IIIC1 cervical cancer. Surgical staging could lead to treatment modification and to improved para-aortic and distant control., Primary Objectives: To demonstrate if chemoradiation with tailored external beam radiation field based on surgical staging and pathologic examination of the para-aortic lymph node is associated with improved 3-year disease-free survival compared with patients staged with PET/CT staging only., Study Hypothesis: Surgical staging followed by tailored chemoradiation will improve disease-free survival while avoiding unnecessary prophylactic extended-field chemoradiation in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIC1 cervical cancer., Trial Design: This is an international multicenter, randomized, phase III study. Eligible patients will be randomized 1:1 between PET/CT staging followed by chemoradiation (control arm), or surgical staging followed by tailored chemo-radiation (experimental arm). Randomization will be stratified by tumor stage according to TNM classification, center, and adjuvant treatment., Major Inclusion/exclusion Criteria: Main inclusion criteria are histologically proven PET/CT FIGO stage IIIC1 cervical cancer. Main exclusion criteria include unequivocal positive common iliac or para-aortic lymph node at pre-therapeutic imaging PET/CT., Primary Endpoints: The primary endpoint is disease-free survival defined as the time from randomization until first relapse (local, regional, or distant), or death from any cause., Sample Size: 510 eligible patients ESTIMATED DATES FOR COMPLETING ACCRUAL AND PRESENTING RESULTS: The estimated date for completing accrual will be Q2 2027. The estimated date for presenting results will be Q4 2030., Trial Registration Number: NCT05581121., Competing Interests: Competing interests: None declared., (© IGCS and ESGO 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
- Full Text
- View/download PDF
12. 5-fluorouracil with oxaliplatin and/or irinotecan for advanced sinonasal intestinal-type adenocarcinoma (ITAC).
- Author
-
Sarradin V, Betrian S, Chaltiel L, Brac De La Perriere C, and Delord JP
- Subjects
- Humans, Irinotecan therapeutic use, Oxaliplatin therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Camptothecin therapeutic use, Retrospective Studies, Fluorouracil, Leucovorin, Colorectal Neoplasms drug therapy, Pancreatic Neoplasms drug therapy, Adenocarcinoma drug therapy
- Abstract
Introduction: Sinonasal intestinal-type adenocarcinoma (ITAC) is a rare tumor, typically found in the ethmoid or upper nasal cavity. There is no standard systemic treatment for metastatic/locally advanced disease ineligible for upfront surgery or radiotherapy., Methods: Patients treated between 2015 and 2021 in our institution with a fluoropyrimidine plus oxaliplatin and/or irinotecan for advanced ITAC were retrospectively assessed for overall survival (OS), progression-free survival (PFS) and tumoral responses., Results: Six patients without meningeal involvement received chemotherapy (three FOLFOX, two FOLFIRI, one FOLFIRINOX). All achieved a response, including those with brain extension. Median PFS with FOLFOX and FOLFIRI was similar (6.0 months, 95%CI 5.8-NR; 5.8 months, 95%CI 5.8-NR respectively). Three patients had meningeal involvement with meningitis symptoms and received first-line therapy. All had rapid disease progression (median PFS 1.2 months, 95%CI 1.0-NR) DISCUSSION: FOLFOX, FOLFIRI or FOLFIRINOX appear to have anti-tumor efficacy for metastatic or locally advanced unresectable ITAC, except in cases of carcinomatous meningitis. These regimens require further evaluation., (Copyright © 2022 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
13. Impact of pattern of recurrence on post-relapse survival according to surgical timing in patients with advanced ovarian cancer.
- Author
-
Angeles MA, Spagnolo E, Cabarrou B, Pérez-Benavente A, Gil Moreno A, Guyon F, Rychlik A, Migliorelli F, Bataillon G, Navarro AS, Betrian S, Ferron G, Hernández A, and Martinez A
- Subjects
- Humans, Female, Neoplasm Staging, Neoplasm Recurrence, Local pathology, Carcinoma, Ovarian Epithelial pathology, Prognosis, Neoadjuvant Therapy, Retrospective Studies, Cytoreduction Surgical Procedures methods, Chemotherapy, Adjuvant, Ovarian Neoplasms drug therapy, Ovarian Neoplasms surgery, Ovarian Neoplasms pathology
- Abstract
Objective: Our study aimed to evaluate the association between timing of cytoreductive surgery and pattern of presentation of the first recurrence in patients with advanced ovarian cancer. We also aimed to assess the impact of the pattern of recurrence on post-relapse overall survival according to surgical timing., Methods: This retrospective multicenter study evaluated patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIC-IV ovarian cancer. Patients had undergone either primary debulking surgery, early interval debulking surgery after 3-4 cycles of neoadjuvant chemotherapy, or delayed debulking surgery after 6 cycles, with minimal or no residual disease, between January 2008 and December 2015. Survival analyses were conducted using the Log-rank test and the Cox model. Cumulative incidences of the different patterns of recurrence were estimated using a competing risks methodology., Results: A total of 549 patients were included: 175 (31.9%) patients had primary, 224 (40.8%) early interval, and 150 (27.3%) delayed debulking surgery. The cumulative incidence of peritoneal recurrences at 2 years was higher with increasing neoadjuvant cycles (24.4%, 30.9% and 39.2%; p=0.019). For pleural or pulmonary recurrences, it was higher after early interval surgery (9.9%, 13.0% and 4.1%; p=0.022). Median post-relapse overall survival was 33.5 months (95% confidence interval (CI) (24.3 to 44.2)), 26.8 months (95% CI (22.8 to 32.6)), and 24.5 months (95% CI (18.6 to 29.4)) for primary, early interval, and delayed debulking surgery groups, respectively (p=0.025). The pattern of recurrence in a lymph node (hazard ratio (HR) 0.42, 95% CI (0.27 to 0.64)), delayed surgery (HR 1.53, 95% CI (1.11 to 2.13)) and time to first recurrence (HR 0.95, 95% CI (0.93 to 0.96)) were associated with post-relapse overall survival. For primary and early interval surgery, lymph node recurrences were associated with significantly longer post-relapse overall survival., Conclusions: The pattern of first recurrence was associated with timing of surgery, with peritoneal recurrences being more frequent with the increasing number of cycles of neoadjuvant chemotherapy. Lymph node recurrences were associated with better prognosis, having higher post-relapse overall survival. This improved prognosis of lymphatic recurrences was not observed in patients who underwent delayed surgery., Competing Interests: Competing interests: None declared., (© IGCS and ESGO 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
- Full Text
- View/download PDF
14. [Application in France of the 2021 European recommendations on endometrial cancer].
- Author
-
Deluche E, Marti C, Jochum F, Bendifallah S, Azaïs H, Deidier J, Cockenpot V, Menoux I, Kissel M, Balaya V, Betrian S, Mathevet P, Chargari C, Gouy S, Genestie C, Uzan C, Devouassoux-Shisheboran M, Guyon F, Akladios C, Body N, and Guani B
- Subjects
- Female, Humans, France, Medical Oncology, Pathologists, Radiation Oncology, Endometrial Neoplasms therapy, Endometrial Neoplasms pathology
- Abstract
The latest European recommendations of the European Societies of Gynecological Oncology (ESGO), Radiotherapy and Oncology (ESTRO) and Anatomopathology (ESP) concerning the management of patients with endometrial cancer were published in 2021. On behalf of the French Society of Gynecologic Oncology (SFOG) and the SFOG campus, we wish to summarize for the French-speaking readership the main measures with a more specific application for France. We also incorporate data from a Delphi survey conducted with a panel of French and French-speaking Swiss experts. The data presented in this article relate to histo-molecular characteristics, radiological data of endometrial cancer, and management of low-risk, intermediate-risk, intermediate-high-risk, and metastatic cancers. The aim of this review article is to show the application of the latest international recommendations to clinicians and pathologists for the implementation of these recommendations., (Copyright © 2022 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
15. Management of Endometrial Cancer: French Society of Onco-Gynecology's Evaluation through a Delphi Survey.
- Author
-
Marti C, Deluche E, Jochum F, Bendifallah S, Azais H, Deidier J, Cockenpot V, Menoux I, Balaya V, Betrian S, Chargari C, Gouy S, Genestie C, Feki A, Uzan C, Guyon F, Devouassoux-Shisheboran M, Body N, Akladios C, Mathevet P, Guani B, and On Behalf Of The Sfog And The Sfog Campus
- Abstract
Our aim was to assess the opinion of a panel of experts and obtain a consensus on the management of endometrial cancer in France and French Switzerland. A Delphi survey was carried out among a panel of French and French-speaking Swiss experts. The first questionnaire included 65 questions divided into eight categories: characterization of experts, histo-molecular characteristics and radiological data of endometrial cancer, and management of low-risk, intermediate-risk, intermediate-high-risk, high-risk, and metastatic cancers. The experts were asked to reply on a 9-point scale, both on the validity and the clarity of each question. After the answers were analyzed, a second questionnaire was sent to the same experts. The study took place between December 2021 and March 2022. Further, 58 (57.4%) of the 101 experts responded in the first round, and 39 recommendations were obtained (60%). Six questions were voted redundant and 20 discordant. These questions were reformulated, and, at the end of the second round, 17 recommendations were validated (85%). In total, the study presents an analysis of 56 questions and related responses. Expert advice helps to clarify non-consensual issues, standardize the management of endometrial cancer, and optimize clinical practices.
- Published
- 2022
- Full Text
- View/download PDF
16. Survival impact of histological response to neoadjuvant chemotherapy according to number of cycles in patients with advanced ovarian cancer.
- Author
-
Betrian S, Angeles MA, Gil Moreno A, Cabarrou B, Deslandres M, Ferron G, Mery E, Floquet A, Guyon F, Pérez-Benavente A, Spagnolo E, Rychlik A, Gladieff L, Hernández Gutiérrez A, and Martinez A
- Abstract
Objective: We sought to evaluate the impact of chemotherapy response score according to the number of cycles of neoadjuvant chemotherapy, on disease-free survival and overall survival, in patients with advanced epithelial ovarian cancer ineligible for primary debulking surgery., Methods: This multicenter retrospective study included patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIC-IV epithelial ovarian cancer who underwent 3-4 or 6 cycles of a platinum and taxane-based neoadjuvant chemotherapy, followed by complete cytoreduction surgery (CC-0) or cytoreduction to minimal residual disease (CC-1), between January 2008 and December 2015, in four institutions. Disease-free survival and overall survival were assessed according to the histological response to chemotherapy defined by the validated chemotherapy response score., Results: A total of 365 patients were included: 219 (60.0%) received 3-4 cycles of neoadjuvant chemotherapy, and 146 (40.0%) had 6 cycles of neoadjuvant chemotherapy before cytoreductive surgery. There were no significant differences in early relapses, disease-free survival, and overall survival according to the number of neoadjuvant chemotherapy cycles. However, regardless of the number cycles of neoadjuvant chemotherapy, persistent extensive histological disease (chemotherapy response score 1-2) was significantly associated with a higher peritoneal cancer index, minimal residual disease (CC-1), and early relapses. Median disease-free survival in patients with complete or near-complete response (score 3) was 28.3 months (95% CI 21.6 to 36.8), whereas it was 16.3 months in patients with chemotherapy response score 1-2 (95% CI 14.7 to 18.0, p<0.001)., Conclusion: In our cohort, the number of neoadjuvant chemotherapy cycles was not associated with disease-free survival or overall survival. Chemotherapy response score 3 improved oncological outcome regardless of the number of neoadjuvant chemotherapy cycles., Competing Interests: Competing interests: None declared., (© IGCS and ESGO 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
- Full Text
- View/download PDF
17. Results of a 2021 French National Survey on Management of Patients with Advanced Stage Epithelial Ovarian Cancer.
- Author
-
Drouin L, Guani B, Balaya V, Azaïs H, Betrian S, Bolze PA, Dabi Y, Kerbage Y, Sanson C, Zaccarini F, Mathevet P, Lécuru F, Guyon F, Akladios C, Bendifallah S, Deluche E, and On Behalf Of The Sfog Campus Young Of French Society Of Gynecological Oncology
- Abstract
Background: The aim of this study was to assess current French practices in the management of patients with advanced epithelial ovarian cancer., Method: a 58-question electronic survey was distributed anonymously to the members of the SFOG (French Society of Gynaecological Oncology), GINECO-ARCAGY (National Investigators Group for Ovarian and Breast Cancer Studies in France) and FRANCOGYN (French research group in oncological and gynaecological surgery). Initial diagnostic workup and staging, pathological data, surgical data, treatments and follow-up strategies were assessed., Results: a total of 107 participants responded to emailed surveys. Most of the respondents were obstetrician-gynaecologists (37.4%), surgical oncologists (34.6%) and medical oncologists (17.8%). According to most (76.8%) participants, less than 50% of patients were eligible for primary debulking surgery (PDS). The LION study criteria were applied in 69.5% of cases during PDS and 39% after chemotherapy. The timing of BRCA testing was very heterogeneous and ranged from 1 to 6 months. The use of bevacizumab as an adjuvant schedule was lower in cases of no residual disease (for 54.5% of respondents) compared to cases of residual disease (for 63.6% of respondents). In cases of BRCA1-2 mutations, olaparib was given by 75.8-84.8% of respondents, whereas niraparib was given in cases of BRCA wild-type diseases., Conclusion: this survey provides an extensive and a unique review of current French practices in the management of patients with advanced epithelial ovarian cancer in 2021.
- Published
- 2021
- Full Text
- View/download PDF
18. Performance of Multiparametric Functional Imaging to Assess Peritoneal Tumor Burden in Ovarian Cancer.
- Author
-
Mallet E, Angeles MA, Cabarrou B, Chardin D, Viau P, Frigenza M, Navarro AS, Ducassou A, Betrian S, Martínez-Gómez C, Tanguy Le Gac Y, Chantalat E, Motton S, Ferron G, Barranger E, Gabiache E, and Martinez A
- Subjects
- Female, Fluorodeoxyglucose F18, Humans, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals, Retrospective Studies, Tomography, X-Ray Computed, Tumor Burden, Ovarian Neoplasms diagnostic imaging, Peritoneal Neoplasms diagnostic imaging
- Abstract
Purpose: The aim of the study was to evaluate the clinical utility of pretreatment 18F-FDG PET/CT with quantitative evaluation of peritoneal metabolic cartography in relation to staging laparoscopy for ovarian carcinomatosis., Patients and Methods: A retrospective review of prospectively collected data from 84 patients with FIGO (International Federation of Gynecology and Obstetrics) stage IIIC to IV ovarian cancer was carried out. All patients had a double-blinded 18F-FDG PET/CT review. Discriminant capacity of metabolic parameters to identify peritoneal carcinomatosis in the 13 abdominal regions according to the peritoneal cancer index was estimated with area under the receiver operating characteristic curve (AUC)., Results: The metabolic parameter showing the best trade-off between sensitivity and specificity to predict peritoneal extension compared with peritoneal cancer index score was the metabolic tumor volume (MTV), with a Spearman ρ equal to 0.380 (P < 0.001). The AUC of MTV to diagnose peritoneal involvement in the upper abdomen (regions 1, 2, and 3) ranged from 0.740 to 0.765. MTV AUC values were lower in the small bowel regions (9-12), ranging from 0.591 to 0.681, and decreased to 0.487 in the pelvic region 6. 18F-FDG PET/CT also improved the detection of extra-abdominal disease, upstaging 35 patients (41.6%) from stage IIIC to IV compared with CT alone and leading to treatment modification in more than one third of patients., Conclusions: 18F-FDG PET/CT metrics are highly accurate to reflect peritoneal tumor burden, with variable diagnostic value depending on the anatomic region. MTV is the most representative metabolic parameter to assess peritoneal tumor extension., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
19. [Reprint of: SFOG Campus, A new group is born!]
- Author
-
Akladios C, Bendifallah S, Deluche E, Betrian S, Espenel S, Jochum F, Babin G, and Guyon F
- Published
- 2021
- Full Text
- View/download PDF
20. Improving patient selection for immuno-oncology phase 1 trials: External validation of six prognostic scores in a French Cancer Center.
- Author
-
Al Darazi G, Martin E, Delord JP, Korakis I, Betrian S, Estrabaut M, Poublanc M, Gomez-Roca C, and Filleron T
- Abstract
We compared the performance of six prognostic scores (Royal Marsden Hospital, MDACC: MD Anderson Clinical Center and MDACC + NLR: neutrophil-to-lymphocyte ratio, MD Anderson - immune checkpoint inhibitors (MDA-ICI), GRIm: Gustave Roussy Immune Score and LIPI: Lung Immune Prognostic Index) in predicting overall survival (OS) in phase I trial patients treated with immune checkpoint inhibitors (ICI). Medical records of patients with advanced solid tumors enrolled in ICI phase I trials between 2015 and 2018 at Institut Universitaire du Cancer de Toulouse-Oncopole were reviewed. The performance of prognostic scores on OS was compared using different criteria. A total of 259 patients were included. Median age was 63 years (range: 18-83). Main primary cancers were melanoma (19%), head and neck (16%), lung (13%) and bladder (10%). With a median follow-up of 15 months (95% confidence interval [CI] = [11.6;17.5]), median OS was 12.5 months (95% CI = [10.3;16.0]). All scores were associated with OS. The MDACC, LIPI and GRIm scores performed better than the others. Concordance of risk group assignment between the scoring systems was poor. According to our results, the MDACC, GRIm and LIPI scores better suited to ICI phase I settings. Adequate scoring would allow better patient selection in early ICI trials, especially during the critical period of dose escalation, and in proof-of-concept expansion cohorts., (© 2020 UICC.)
- Published
- 2021
- Full Text
- View/download PDF
21. Comparison of SPECT-CT with intraoperative mapping in cervical and uterine malignancies.
- Author
-
Navarro AS, Angeles MA, Migliorelli F, Illac C, Martínez-Gómez C, Leray H, Betrian S, Chantalat E, Tanguy Le Gac Y, Motton S, Querleu D, Ferron G, Gabiache E, and Martinez A
- Subjects
- Adult, Aged, Aged, 80 and over, Coloring Agents administration & dosage, Endometrial Neoplasms pathology, Female, Humans, Lymphoscintigraphy methods, Middle Aged, Radiopharmaceuticals administration & dosage, Retrospective Studies, Sentinel Lymph Node pathology, Sentinel Lymph Node surgery, Single Photon Emission Computed Tomography Computed Tomography, Uterine Cervical Neoplasms pathology, Endometrial Neoplasms diagnostic imaging, Sentinel Lymph Node diagnostic imaging, Uterine Cervical Neoplasms diagnostic imaging
- Abstract
Introduction: The objective was to evaluate whether hybrid imaging combining single photon emission tomography with computed tomography (SPECT/CT) provides additional clinical value for dectection of sentinel lymph nodes (SLNs) compared with intraoperative combined mapping in uterine and cervical malignancies., Methods: This was a retrospective study of prospectively collected data from patients with stages IA-IB2 cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) 2018) or stage I endometrial cancer, who underwent preoperative SPECT/CT for SLN detection. All included patients had dual injection of technetium-99m (
99m Tc) with patent blue or indocyanine green., Results: A total of 171 patients were included with 468 SLNs detected during surgery: 146/171 patients (85.4%) had both radiotracer and blue injection whereas 25/171 patients (14.6%) had radiotracer and indocyanine green injected. The overall detection rate was 95.3%. The detection rate of SLN mapping was 74.9% for SPECT/CT, 90.6% for99m Tc, 91.8% for blue dye, and 100% for indocyanine green. Bilateral drainage was found in 140 patients (81.9%), detected by99m Tc in 105 patients (61.4%), by blue in 99 patients (67.3%), by indocyanine green in 23 patients (92%), and by SPECT/CT in 62 patients (36.4%). Atypical SLN locations were identified by SPECT/CT in 64 patients (37.4%), by 99mTc in 28 patients (16.4%), by blue in 17 patients (9.9%), and by indocyanine green in 8 patients (4.7%). Sensitivity and negative predictive value of SLN biopsy to detect lymph node metastasis using dual injection of different intraoperative combined techniques were 88.9% and 97.5%, respectively., Conclusion: SPECT/CT enhanced topographic delineation of SLN and more accurately identified drainage to atypical locations. Fluorescent SLN mapping using indocyanine green offered the highest SLN detection rate. When indocyanine green was used, SPECT/CT did not increase SLN detection, and did not add further information to improve lymph node localization and removal., Competing Interests: Competing interests: None declared., (© IGCS and ESGO 2021. No commercial re-use. See rights and permissions. Published by BMJ.)- Published
- 2021
- Full Text
- View/download PDF
22. SFOG Campus, A new group is born!
- Author
-
Akladios C, Bendifallah S, Deluche E, Betrian S, Espenel S, Jochum F, Babin G, and Guyon F
- Published
- 2020
- Full Text
- View/download PDF
23. Sicca Syndrome Induced by Immune Checkpoint Inhibitor Therapy: Optimal Management Still Pending.
- Author
-
Ortiz Brugués A, Sibaud V, Herbault-Barrés B, Betrian S, Korakis I, De Bataille C, Gomez-Roca C, Epstein J, and Vigarios E
- Subjects
- Humans, Immunotherapy, Sjogren's Syndrome
- Published
- 2020
- Full Text
- View/download PDF
24. First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors.
- Author
-
Elez E, Gomez-Roca C, Soto Matos-Pita A, Argiles G, Valentin T, Coronado C, Iglesias J, Macarulla T, Betrian S, Fudio S, Zaragoza K, Tabernero J, and Delord JP
- Subjects
- Adult, Aged, Antineoplastic Agents adverse effects, Antineoplastic Agents blood, Antineoplastic Agents pharmacokinetics, Female, Humans, Male, Maximum Tolerated Dose, Middle Aged, Neoplasms metabolism, Peripheral Nervous System Diseases chemically induced, Polyketides adverse effects, Polyketides blood, Polyketides pharmacokinetics, Pyrones adverse effects, Pyrones blood, Pyrones pharmacokinetics, Treatment Outcome, Tubulin Modulators adverse effects, Tubulin Modulators blood, Tubulin Modulators pharmacokinetics, Young Adult, Antineoplastic Agents administration & dosage, Neoplasms drug therapy, Polyketides administration & dosage, Pyrones administration & dosage, Tubulin Modulators administration & dosage
- Abstract
Background Plocabulin (PM060184) is a novel marine-derived microtubule inhibitor that acts as an antitumor agent. This first-in-human study evaluated dose-limiting toxicities (DLT) to define the maximum tolerated dose (MTD) and phase II recommended dose (RD) of plocabulin given as a 10-min infusion on Day (D) 1, D8 and D15 every four weeks. Patients and methods Forty-four patients with advanced solid tumors received plocabulin following an accelerated titration design. Results Plocabulin was escalated from 1.3 mg/m
2 to 14.5 mg/m2 , which was defined as the MTD. No RD was confirmed, because frequent dose delays and omissions resulted in low relative dose intensity (66%) at the 12.0 mg/m2 expansion cohort. The main DLT was grade 3 peripheral sensory neuropathy (PSN); other DLTs were grade 4 tumor lysis syndrome, grade 4 cardiac failure and grade 3 myalgia. Toxicities were mainly mild to moderate, and included abdominal pain, myalgia, fatigue, nausea, and vomiting. Myelosuppression was transient and manageable. Plocabulin had a half-life of ~4 h and a wide diffusion to peripheral tissues. Antitumor response was observed in cervix carcinoma and heavily pretreated metastatic non-small cell lung cancer patients, and disease stabilization (≥3 months) in patients with colorectal, thymic, gastrointestinal stromal and breast tumors, among others. The clinical benefit rate was 33%. Conclusion The main DLT of plocabulin was PSN, as anticipated for a tubulin-binding agent. Since encouraging antitumor activity was observed, efforts to improve toxicity and to find the RD were planned in other trials evaluating D1&D8 and D1-D3 plus D15-D17 schedules.- Published
- 2019
- Full Text
- View/download PDF
25. Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant /relapse-initiating CLL cells: a rationale for combination treatment.
- Author
-
Betrian S, Ysebaert L, Heider KH, Delord JP, Fournié JJ, and Quillet-Mary A
- Subjects
- Antibodies, Monoclonal, Humanized therapeutic use, Antineoplastic Agents, Immunological therapeutic use, Cell Proliferation drug effects, Drug Synergism, Humans, Leukemia, Lymphocytic, Chronic, B-Cell pathology, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local pathology, Purines pharmacology, Quinazolinones pharmacology, Recurrence, Treatment Outcome, Tumor Microenvironment drug effects, Antibodies, Monoclonal, Humanized pharmacology, Antigens, Neoplasm immunology, Antineoplastic Agents, Immunological pharmacology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Drug Resistance, Neoplasm drug effects, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Purines administration & dosage, Quinazolinones administration & dosage, Tetraspanins immunology
- Abstract
Competing Interests: KH Heider is an employee of Boehringer Ingelheim. The remaining authors declare no conflict of interest.
- Published
- 2016
- Full Text
- View/download PDF
26. Bendamustine is effective in T-cell prolymphocytic leukaemia.
- Author
-
Herbaux C, Genet P, Bouabdallah K, Pignon JM, Debarri H, Guidez S, Betrian S, Leleu X, Facon T, Morschhauser F, Damaj G, Cazin B, and Ysebaert L
- Subjects
- Aged, Aged, 80 and over, Bendamustine Hydrochloride, Drug Evaluation methods, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Antineoplastic Agents, Alkylating therapeutic use, Leukemia, Prolymphocytic, T-Cell drug therapy, Nitrogen Mustard Compounds therapeutic use
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.