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1. Industrial, Collaborative and Mobile Robotics in Latin America: Review of Mechatronic Technologies for Advanced Automation

Author: Jose Cornejo, S. Barrera, C. A. Herrera Ruiz, F. Gutierrez, M. O. Casasnovas, Leonardo Kot, M. A. Solis, R. Larenas, F. Castro-Nieny, M. R. Arbulú Saavedra, R. Rodríguez Serrezuela, Y. Muñoz Londoño, Alejandro Serna, D. Ortega-Aranda, S. Aranda-Miramontes, I. Chang, M. Cardona, A. Carrasquilla-Batista, R. Palomares, R. Rodriguez, Ruben Parisuaña, Miguel Bórquez, Oscar Navarro, Fernando Sanchez, I. A. Bonev, Jonathan Coulombe, F. Martín Rico, B. L. Treviño-Elizondo, H. García-Reyes, A. Sollazzo, A. Dubor, A. Markopoulou, C. De Marinis, Marco Chacin, Andres Mora, M. Pérez-Ruiz, A. Ribeiro, and E. A. L'Huillier
Subjects: mechatronics, robotics, industry, automation, human-robot interaction, latin america., Technology (General), T1-995, Social sciences (General), H1-99
Abstract: Mechatronics and Robotics (MaR) have recently gained importance in product development and manufacturing settings and applications. Therefore, the Center for Space Emerging Technologies (C-SET) has managed an international multi-disciplinary study to present, historically, the first Latin American general review of industrial, collaborative, and mobile robotics, with the support of North American and European researchers and institutions. The methodology is developed by considering literature extracted from Scopus, Web of Science, and Aerospace Research Central and adding reports written by companies and government organizations. This describes the state-of-the-art of MaR until the year 2023 in the 3 Sub-Regions: North America, Central America, and South America, having achieved important results related to the academy, industry, government, and entrepreneurship; thus, the statistics shown in this manuscript are unique. Also, this article explores the potential for further work and advantages described by robotic companies such as ABB, KUKA, and Mecademic and the use of the Robot Operating System (ROS) in order to promote research, development, and innovation. In addition, the integration with industry 4.0 and digital manufacturing, architecture and construction, aerospace, smart agriculture, artificial intelligence, and computational social science (human-robot interaction) is analyzed to show the promising features of these growing tech areas, considering the improvements to increase production, manufacturing, and education in the Region. Finally, regarding the information presented, Latin America is considered an important location for investments to increase production and product development, taking into account the further proposal for the creation of the LATAM Consortium for Advanced Robotics and Mechatronics, which could support and work on roboethics and education/R+D+I law and regulations in the Region. Doi: 10.28991/ESJ-2023-07-04-025 Full Text: PDF
Published: 2023
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2. Posterior Interosseous Nerve Palsy Associated with Multiple Epiphyseal Dysplasia

Author: M A De la Red-Gallego, S. Barrera-Ochoa, and Mónica Fernández Alvarez
Subjects: multiple epiphyseal dysplasia, posterior interosseous nerve compression, radial head dislocation, Surgery, RD1-811
Abstract: Multiple epiphyseal dysplasia is a condition that courses with a retarded epiphyseal development and may cause joint dysmorphia. We report a case of posterior interosseous nerve palsy in a child with dysplasia. After a physical examination and complementary diagnostic tests that revealed posterior interosseous nerve compression neuropathy, surgical neurolysis og the posterior interosseous nerve was performed at level of the the arcade of Frohse. The satisfactory evolution of the patient confirmed our diagnosis. Attention must be paid to the onset of signs or symptoms of nerve compression in these patients.
Published: 2022
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3. Sherd Shatter Patterns Experiment

Author: S. Evans and S. Barrera
Subjects: ceramics, experiment, neolithic, chalcolithic, bronze age, iron age, roman era, viking age, early middle ages, late middle ages, newer era, canada, Museums. Collectors and collecting, AM1-501, Archaeology, CC1-960
Abstract: In field archaeology, the importance of non-diagnostic sherds is often overlooked. This archaeological experiment suggests that archaeologists should take into greater consideration, contexts where sherds are found grouped together in close proximity. The authors tested a series of experimental drops of modern pots which were treated as substitutions for ancient examples. Dispersion patterns of the pot sherds were analyzed to determine if it was possible to understand how vessels were used, and thus broken and discarded by people in ancient times. Amongst the variables tested were various vessel sizes filled with different contents which were dropped from varying heights. The results produced interesting findings that could indeed prove useful to archaeologists if they were applied in the field and laboratory. Due to budget constraints and the narrow scope of the project, only preliminary findings were addressed. In future, the authors would encourage other scholars to build upon their promising research which could be beneficial to archaeologists around the world.
Published: 2017

4. Presencia de malnutrición y riesgo de malnutrición en ancianos institucionalizados con demencia en función del tipo y estadío evolutivo Presence of malnutrition and risk of malnutrition in institutionalized elderly with dementia according to the type and deterioration stage

Author: M.ª A. Camina Martín, S. Barrera Ortega, L. Domínguez Rodríguez, C. Couceiro Muiño, B. de Mateo Silleras, and M.ª P. Redondo del Río
Subjects: Evaluación nutricional, Malnutrición, Ancianos, Demencia, Mini Nutritional Assessment, Nutritional Assessment, Malnutrition, Elderly, Dementia, Nutritional diseases. Deficiency diseases, RC620-627
Abstract: Objetivo: Determinar si existen diferencias en el estado nutricional de los pacientes con demencia en función del tipo y la severidad de la misma. Método: Mediante un estudio transversal se realizó una valoración del estado nutricional (valoración antropométrica, Mini Nutricional Assessment, protocolo de Chang) en 83 ancianos institucionalizados con diagnóstico de demencia en estadíos evolutivos 5, 6 y 7 de las escalas GDS (Global Deterioration Scale) y FAST (Functional Assessment Stating). Los resultados se analizaron mediante los tests Chi-cuadrado, ANOVA o Kruskal-Wallis, contrastes a posteriori de Scheffé y test de tendencia lineal. La significación se alcanzó con p < 0,05. Resultados: La edad media de los residentes fue de 81,22 años. El IMC reveló que el 21% de la muestra presentaba riesgo de malnutrición y el 14,5% malnutrición por defecto. En cambio, el MNA clasificó al 56,6% de los residentes en situación de riesgo de malnutrición y al 41% con malnutrición. Según el método de Chang el porcentaje de pacientes malnutridos ascendió al 75,9%. Ninguna de estas variables mostró asociación con el tipo de demencia. Se observó una asociación significativa entre el estadío evolutivo de la demencia y el IMC (p = 0,004), MNA (p = 0,002 y p = 0,006 para la puntuación y la categoría, respectivamente), circunferencia muscular del brazo (p = 0,043) y circunferencia de la pantorrilla (p = 0,043); aunque no para el porcentaje de masa grasa ni para el diagnóstico nutricional establecido por el método de Chang (grado y tipo de MN). El test de tendencia lineal confirmó que tanto las puntuaciones del MNA y del IMC, como los valores de la circunferencia muscular del brazo y de la circunferencia de la pantorrilla fueron menores en los estadíos de demencia más severos. Conclusión: Independientemente del tipo de demencia, la presencia de malnutrición en ancianos institucionalizados aumenta conforme lo hace el estadío evolutivo de la misma.Objective: To determine if there exist differences in the nutritional status of patients with dementia according to the type and severity of the disease. Method: In this cross-sectional study we carried out an assessment of the nutritional status (anthropometrical assessment, Mini Nutritional Assessment, Chang´s protocol) in 83 institutionalized elderly diagnosed with dementia at evolutionary states of 5, 6, and 7 of GDS (Global Deterioration Scale) and FAST (Functional Assessment Stating). The results were analyzed by the Chi-squared, ANOVA, or Kruskal-Wallis tests, the Scheffé´s posteriori contrasts, and the linear trend test. Significance was considered at p < 0.05. Results: The mean age of the patients was 81.22 years. The BMI revealed that 21% of the sample were at risk for malnourishment and 14.5% were malnourished. However, by using the MNA, 56.6% of the patients were at risk for malnourishment and 41% were malnourished. According to the Chang's method, the percentage of malnourished patients was increased to 75.9%. None of these variables showed an association with the type of dementia. A significant association was observed between the evolutionary state of dementia and the BMI (p = 0.004), MNA (p = 0.002 and p = 0.006 for the score and the category, respectively), the muscle circumference of the arm (p = 0.043) and the calf circumference (p = 0.043) but not with the percentage of fat mass nor the nutritional diagnosis established by the Chang´s method (degree and type of MN). The linear trend test confirmed that both the MNA and BMI scores and the muscle circumference of the arm and the calf circumference were lower in the more severe dementia states. Conclusion: Irrespective of the type of dementia, the presence of malnourishment in institutionalized elderly increases in parallel to the evolutionary degree of the dementia.
Published: 2012

5. The Writing-Reading Nexus

Author: Nancy Nelson, Kim Skinner, and Estanislado S. Barrera
Published: 2022
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6. Enhanced Mechanical Properties of Natural Rubber by Block Copolymer-Based Porous Carbon Fibers

Author: Zacary L. Croft, Haibo Zhao, Wenqi Zhao, Cindy S. Barrera, Guoliang Liu, Janice Lisa Tardiff, Zhen Xu, and John Elliott
Subjects: Porous carbon, Materials science, Polymers and Plastics, Natural rubber, Process Chemistry and Technology, visual_art, Organic Chemistry, Copolymer, visual_art.visual_art_medium, Composite material
Published: 2021
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7. Cis-regulatory variation in relation to sex and sexual dimorphism in Drosophila melanogaster

Author: Prashastha Mishra, Tania S. Barrera, Karl Grieshop, and Aneil F. Agrawal
Abstract: Much of sexual dimorphism is likely due to sex-biased gene expression, which results from differential regulation of a genome that is largely shared between males and females. Here we use allele-specific expression to explore cis-regulatory variation in Drosophila melanogaster in relation to sex. We test for sex differences in cis-regulatory effects as well as examine patterns of cis-regulatory with respect to two other levels of variation in sexual dimorphism: (i) across genes varying in their degree of sex-biased expression, and (ii) among tissues that vary in their degree of dimorphism (e.g., relatively low dimorphism in heads vs high dimorphism in gonads). We uncover evidence of widespread cis-regulatory variation in all tissues examined, with female-biased genes being especially enriched for said variation. A sizeable proportion of cis-regulatory variation is observed to have sex-specific effects, with sex-dependent cis effects being more frequent in gonads than in heads. Finally, we detect some genes with reversed allelic imbalance between the sexes. Such variants could provide a mechanism for sex-specific dominance reversals, a phenomenon important for sexually antagonistic balancing selection.
Published: 2022
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8. Induction of Immunogenic Cell Death in Breast Cancer by Conductive Polymer Nanoparticle-Mediated Photothermal Therapy

Author: Tania Betancourt, Jessica S. Barrera, Emilio J. Lara, Madeline Elaine Huff, Fatma Özge Gökmen, James W. Tunnell, and Jennifer A. Irvin
Subjects: Polymers and Plastics, business.industry, Process Chemistry and Technology, medicine.medical_treatment, Organic Chemistry, food and beverages, Cancer, Immunotherapy, Photothermal therapy, medicine.disease, Cancer treatment, Breast cancer, Cancer cell, medicine, Cancer research, Immunogenic cell death, business
Abstract: Emerging research in cancer immunotherapies has pointed toward the need for companion therapies that lead to immunogenic cell death. Photothermal therapy (PTT) can not only cause cancer cell death ...
Published: 2020
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9. Epigenetic variations due to nutritional status in early‐life and its later impact on aging and disease

Author: O. S. Barrera-Vázquez, Rafael Samper-Ternent, Pedro Arroyo, Lizbeth García-Velázquez, and Juan Carlos Gomez-Verjan
Subjects: 0301 basic medicine, Aging, Nutritional Status, Disease, 030105 genetics & heredity, Bioinformatics, Epigenesis, Genetic, Fetal Development, 03 medical and health sciences, Pregnancy, Genetics, medicine, Humans, Obesity, Epigenetics, Child, Socioeconomic status, Genetics (clinical), Fetus, business.industry, Epigenome, medicine.disease, Pregnancy Complications, Malnutrition, Phenotype, 030104 developmental biology, Female, business
Abstract: Epigenetics refers to changes in gene function, not resulting from the primary DNA sequence, influenced by the environment. It provides a link between the molecular regulation of the genome and the environmental signals exposed during the life of individuals (including lifestyle, social behavior, development, and nutrition). Notably, early development (intrauterine or postnatal) is highly influenced by the adverse socioeconomic status that leads to malnutrition or obesity; these conditions induce changes over the fetal epigenetic programming and can be transferred by transgenerational inheritance, inducing alterations of the transcription of genes related to several metabolic and neurological processes. Moreover, obesity during pregnancy, and excessive gestational weight gain are associated with an increased risk of fatal pregnancy complications, and adverse cardio-metabolic, respiratory and cognitive-related outcomes of the future child. However, most of our knowledge in this field comes from experimental animal models, that partially resemble the nutritional effects of humans. In this context, nutritional effects implicated in historical famines represent valuable information about the transgenerational effects of undernutrition and stress. In the present review, we attempt to describe the most outstanding results from the most studied famines about the impact of malnutrition on the epigenome.
Published: 2020
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10. Natural products as a major source of candidates for potential senolytic compounds obtained by in silico screening

Author: Gil A. Magos-Guerrero, Oscar S. Barrera-Vázquez, Juan L. Escobar-Ramírez, and Juan C. Gomez-Verjan
Subjects: Drug Discovery
Abstract: Background: Preclinical studies suggest that senolytic compounds such as quercetin (a natural product) and dasatinib (a synthetic product) decrease senescent cells, reduce inflammation, and alleviate human frailty. This evidence has opened a new field of research for studying the effect of these compounds on age-related dysfunction and diseases. Objective: The present study performed in silico and we identified new potential senolytic candidates from an extensive database that contains natural products (NPs) and semi-synthetic products (SMSs). Methods: Computer programs Chemminer and rcdk packages, which compared the fingerprints of numerous molecules (40,383) with reference senolytics, and the creation of a pharmacological network built with signaling pathways and targets involved in senescence processes were used to identify compounds with a potential activity. Results: Six drug-like candidates (3,4'-dihydroxypropiophenone, baicalein, α, β-dehydrocurvularin, lovastatin, luteolin, and phloretin) were identified. Conclusion: To our knowledge, this is the first time that these six natural molecules have been proposed to have senolytic activity. To validate the methodology employed in the identification of new drug-like senolytics, experimental evidence is needed with models that evaluate senolytic activity.
Published: 2022

11. Liquid Guayule Natural Rubber, a Sustainable Processing Aid, Enhances the Processability, Durability and Dynamic Mechanical Properties of Rubber Composites

Author: Xianjie Ren, Cindy S. Barrera, Janice L. Tardiff, Andres Gil, and Katrina Cornish
Subjects: General Materials Science, processing aid, carbon black, dynamic mechanical properties, damping performance, oil resistance
Abstract: Petroleum-based oils are widely used as processing aids in rubber composites to improve processability but can adversely affect rubber composite performance and increase carbon footprint. In this research, liquid guayule natural rubber (LGNR), produced from guayule natural rubber, was used as a renewable processing aid to replace naphthenic oil (NO) in Hevea natural rubber, styrene-butadiene rubber (SBR) and guayule natural rubber (GNR) composites. The rheological properties, thermal stability, glass transition temperature, dynamic mechanical properties, aging, and ozone resistance of rubber composites with and without NO or LGNR were compared. Natural and synthetic rubber composites made with LGNR had similar processability to those made with NO, but had improved thermal stability, mechanical properties after aging, and ozone resistance. This was due to the strong LGNR–filler interaction and additional crosslinks formed between LGNR and the rubber matrices. The glass transition temperature of SBR composites was reduced by LGNR because of its increased molecular mobility. Thus, unlike NO, LGNR processing aid can simultaneously improve rubber composite durability, dynamic performance and renewability. The commercialization of LGNR has the potential to open a new sustainable processing-aid market.
Published: 2022
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12. Sand transport and placement

Author: S. Barrera and C. Riveros
Published: 2022
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13. Modular real-time resource management in the Rialto operating system.

Author: Michael B. Jones, Paul J. Leach, Richard Draves, and Joseph S. Barrera III
Published: 1995
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14. Sustainable Epoxidized Guayule Natural Rubber, Blends and Composites with Improved Oil Resistance and Greater Stiffness

Author: Xianjie Ren, Cindy S. Barrera, Janice L. Tardiff, and Katrina Cornish
Subjects: natural rubber, epoxidation, dynamic mechanical properties, damping performance, oil resistance, General Materials Science
Abstract: Production of petroleum-based synthetic rubbers (SRs) causes an enormous carbon footprint for the rubber industry. Carbon footprint would be reduced if natural rubber (NR) could take a larger market share and replace significant quantities of SR. However, some SRs have higher oil resistance than NRs, and, in applications where these properties are needed, chemically modified NR will be required. Epoxidation is a chemical modification of NR which partially converts unsaturated bonds on the backbone of NR to epoxy groups. In this research, epoxidized guayule natural rubber (EGNR)/guayule natural rubber (GNR) blends and GNR were used to make carbon black (CB) filled composites. The processability, mechanical properties, swelling behaviors and dynamic mechanical properties were characterized at various epoxide fractions. Composites made with EGNR/GNR had higher oil resistance, wet traction and stiffness than GNR composites, although tensile strength and elongation at break were reduced by epoxidation. EGNR is expected to lead to the development of new NR products with similar properties to SR, eroding SR markets and increasing the sustainability of the rubber industry.
Published: 2022

15. List of contributors

Author: Lukman Ahamad, Sandeep S. Ahankari, S. Anandhan, Irfan Ahmad Ansari, Cindy S. Barrera, Pritom J. Bora, Katrina Cornish, Mrityunjay Doddamani, V. Gayathri, Manas K. Ghorai, Dipita Ghosh, Gopal A. Gupta, Nikhil Gupta, M. Gurunandan, Asad Hanif, T. Hemalatha, Fayaz Jawad, Kamal K. Kar, Dimitris Karapanos, Christos Karkalis, Manzoor R. Khan, null Kishore, Nikolaos Koukouzas, Petros Koutsovitis, S.S. Lahiri, Subodh Kumar Maiti, Ramdas V. Mangore, P.K. Manna, Anil Kumar Misra, Selvakumar Murugesan, Shania Zehra Naqvi, Tanvi Pal, Akshata G. Patil, Sumit Pramanik, T. Raghavendra, Deep Raj, Praveen C. Ramamurthy, Ananth Ramaswamy, Janakarajan Ramkumar, Vaishali Sahu, Zaki A. Siddiqui, N.B. Singh, Sugandha Singh, Pavlos Tyrologou, Muhammad Usman, H.P. Vageesh, and Kapil Dev Verma
Published: 2022
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16. Fly ash as a potential filler for the rubber industry

Author: Cindy S. Barrera and Katrina Cornish
Published: 2022
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17. Self-Tuning Software.

Author: Joseph S. Barrera III
Published: 1993
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18. A Fast Mach Network IPC Implementation.

Author: Joseph S. Barrera III
Published: 1991

19. The Unexplored World of Human Virome, Mycobiome, and Archaeome in Aging

Author: Juan Carlos Gomez-Verjan and O. S. Barrera-Vázquez
Subjects: 0301 basic medicine, Aging, Population, Medical care, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Human virome, Microbiome, education, Phylogeny, Organism, education.field_of_study, Virome, business.industry, Microbiota, Human microbiome, Bacteriome, Archaea, 030104 developmental biology, Evolutionary biology, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Mycobiome
Abstract: In the last decades, improvements in different aspects of sanitation, medical care, and nutrition, among others, have permitted an increase in the average lifespan of human population around the world. These advances have stimulated an increased interest in the study of the aging process and age-sensitive characteristics, such as the microbial community that colonizes the human body (microbiome). The human microbiome is composed of bacteria (bacteriome), archaea (archaeome), fungi (mycobiome), and viruses (virome). To date, research has mainly been centered on the composition of the bacteriome, with other members remain poorly studied. Interestingly, changes in the composition of the microbiome have been implicated in aging and age-related diseases. Therefore, in the present perspective, we suggest expanding the scope to research to include the role and the possible associations that the other members of the microbiome could have in the aging organism. An expanded view of the microbiome would increase our knowledge of the physiology of aging and may be particularly valuable for the treatment and diagnosis of age-related diseases.
Published: 2019
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20. Studies on the influence of surface treatment type, in the effectiveness of structural adhesive bonding, for carbon fiber reinforced composites

Author: V. H. Martínez-Landeros, S.Y. Vargas-Islas, K. Mourtazov, Rafael Ramírez-Bon, Celso E. Cruz-González, and S. Barrera
Subjects: 0209 industrial biotechnology, Materials science, Adhesive bonding, Strategy and Management, Delamination, Reinforced carbon–carbon, 02 engineering and technology, Management Science and Operations Research, 021001 nanoscience & nanotechnology, Industrial and Manufacturing Engineering, Surface energy, Contact angle, 020901 industrial engineering & automation, Fracture toughness, Adhesive, Fiber, Composite material, 0210 nano-technology
Abstract: Primary intent of the present paper is to correlate the effectiveness of surface preparation type (pre-bonding), such as solvent cleaning, sanding (mechanical abrade), chemical etching (alkaline and acid), and peeling of sacrificial surface layer (peel ply) of carbon fiber reinforced composite (CFRC) test specimens, with the corresponding effect to the final strength of adhesive bonding. The analysis was performed by means of several spectroscopic and microscopic techniques, such as XPS, SEM, AFM, and a contact angle measurement technique which provides a direct, fast and easy measurement of the surface energy of the fiber composites. The adhesively bonded carbon fiber composites based on the different surface treatments were mechanically tested by employing the ASTM D 5528-0 (reapproved 2007) standard. The double cantilever beam (DCB) specimen geometry was used to evaluate the value known as opening Mode I inter-laminar fracture toughness (GIC) in adhesive bonds of carbon fiber composite materials. The results were varying between 1 and 1.8 kJ/m2 for GIC analysis and around 50 mm for delamination lengths. The mechanics of the linear elastic fracture is considered a tool for the failure of the laminate in composite materials with cracks or cuts in the plane, due to the presence of damaged zones in the tip of the crack; which is therefore applied to the study of delamination or fracture toughness.
Published: 2019
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21. Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products

Author: Juan Carlos Gomez-Verjan, Gil Alfonso Magos-Guerrero, and O. S. Barrera-Vázquez
Subjects: Senescence, Drug, Aging, Digoxin, senescence, natural products, media_common.quotation_subject, lcsh:QR1-502, Pharmacology, Azithromycin, Biochemistry, chemoinformatics, lcsh:Microbiology, Article, 03 medical and health sciences, chemistry.chemical_compound, Hinokitiol, 0302 clinical medicine, Animals, Humans, Senolytic, Molecular Biology, database, 030304 developmental biology, media_common, 0303 health sciences, Biological Products, Roxithromycin, Navitoclax, Cell growth, Cheminformatics, Tunicamycin, chemistry, Drug development, 030220 oncology & carcinogenesis, senolytics
Abstract: Cellular senescence is a cellular condition that involves significant changes in gene expression and the arrest of cell proliferation. Recently, it has been suggested in experimental models that the elimination of senescent cells with pharmacological methods delays, prevents, and improves multiple adverse outcomes related to age. In this sense, the so-called senoylitic compounds are a class of drugs that selectively eliminates senescent cells (SCs) and that could be used in order to delay such adverse outcomes. Interestingly, the first senolytic drug (navitoclax) was discovered by using chemoinformatic and network analyses. Thus, in the present study, we searched for novel senolytic compounds through the use of chemoinformatic tools (fingerprinting and network pharmacology) over different chemical databases (InflamNat and BIOFACQUIM) coming from natural products (NPs) that have proven to be quite remarkable for drug development. As a result of screening, we obtained three molecules (hinokitiol, preussomerin C, and tanshinone I) that could be considered senolytic compound candidates since they share similarities in structure with senolytic leads (tunicamycin, ginsenoside Rb1, ABT 737, rapamycin, navitoclax, timosaponin A-III, digoxin, roxithromycin, and azithromycin) and targets involved in senescence pathways with potential use in the treatment of age-related diseases.
Published: 2021

22. Invocation Chaining: Manipulating Lightweight Objects across Heavyweight Boundaries.

Author: Joseph S. Barrera III
Published: 1993
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23. Static and dynamic properties of eggshell filled natural rubber composites for potential application in automotive vibration isolation and damping

Author: Cindy S. Barrera and Janice L. Tardiff
Subjects: Renewable Energy, Sustainability and the Environment, Strategy and Management, Building and Construction, Industrial and Manufacturing Engineering, General Environmental Science
Published: 2022
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24. Comparison of principal component analysis and multi-dimensional ensemble empirical mode decomposition for impact damage segmentation in square pulse shearography phase images

Author: Bernardo Cassimiro Fonseca de Oliveira, Armando Albertazzi, Herberth Birck Fröhlich, Tiago Junior de Bortoli, and Estiven S. Barrera
Subjects: Shearography, Computer science, Feature (computer vision), business.industry, Noise (signal processing), Nondestructive testing, Principal component analysis, Segmentation, Context (language use), Pattern recognition, Artificial intelligence, Image segmentation, business
Abstract: Composite materials have mechanical behavior comparable to metallic alloys, with the benefit of being lighter. However, due to their anisotropy, integrity characterization of impact damages remains a challenge. Non-Destructive Testing (NDT) methods are useful in this context, as they achieve success in evaluation while they avoid modifications in the characteristics of the piece. Shearography is an NDT that reveal changes on a surface in response to a load. Yet, shearography outputs carry several unwanted characteristics along with the defect, like background patterns, light changes, and noise. Image segmentation techniques can enhance the capability of automatic measurement of defective areas and also aid supervised methods and feature extractors, which rely on images as inputs. Yet, most of the times image pre-processing is required for better and useful results in segmentation. Principal Component Analysis (PCA) and Multi-dimensional Ensemble Empirical Mode Decomposition (MEEMD) allow this to be done at the same time that they deal with background and light changes, as they decompose the image. Using Matthews Coefficient as a metric for masks comparison, it is shown that MEEMD has better results than PCA, and with lower expanded uncertainty.
Published: 2020
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25. The Carver Cubs Summer Book Club

Author: Estanislado S. Barrera, Brandon Reilly, and Kim Skinner
Subjects: Teacher preparation, Mathematics education, Sociology, Club, Reciprocal
Published: 2020
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26. Agistemus piquinnus Monjaras-Barrera & Johann 2020, n. sp

Author: Monjar��s-Barrera, Jos�� Irving, Silva, Guilherme Liberato Da, Chac��n-Hern��ndez, Julio Cesar, Silva, Onilda Santos Da, Ferla, Noeli Juarez, and Johann, Liana
Subjects: Arthropoda, Stigmaeidae, Arachnida, Prostigmata, Animalia, Biodiversity, Agistemus, Agistemus piquinnus, Taxonomy
Abstract: Agistemus piquinnus Monjar��s-Barrera & Johann n. sp. Zoobank: AC9EF2C2-8565-4982-9AEB-F1DBE9BA2D88 (Figures 1-5) Diagnosis (female) �� Prodorsal and hysterosomal shields smooth; length of seta c 1 longer than the distance between the bases of c 1 and d 1 ; the ratio vi/vi��vi 2.8 (2.8-3.0); ratio c 1 /c 1 ��c 1 2.1 (2.1-2.3); ratio: pob/eye: 3.2 (3.0-3.2). Aggenital shield not defined, bearing two pair of setae (ag 1 -ag 2 ); seta g 1 extending beyond the base of ps 2 ; setae ps 1 and ps 2 slightly barbed and more robust than ps 3 ; femora I��IV 5-4-2-2. SD= Standard Deviation, Published as part of Monjar��s-Barrera, Jos�� Irving, Silva, Guilherme Liberato Da, Chac��n-Hern��ndez, Julio Cesar, Silva, Onilda Santos Da, Ferla, Noeli Juarez & Johann, Liana, 2020, A new species and new record of Agistemus Summers (Acari: Stigmaeidae) associated withCapsicum annuum L. var. glabriusculum (Solanaceae) from Northeastern of Mexico, pp. 470-480 in Acarologia 60 (2) on page 472, DOI: 10.24349/acarologia/20204378, http://zenodo.org/record/4488035, {"references":["Matioli A. L., Ueckermann E. A., Oliveira C. A. L. 2002. Some stigmaeid and eupalopsellid mites from citrus orchards in Brazil (Acari: Stigmaeidae and Eupalopsellidae). Int. J. Acarol., 28: 99 - 120. doi: 10.1080 / 01647950208684287"]}
Published: 2020
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27. Agistemus Summers 1960

Author: Monjar��s-Barrera, Jos�� Irving, Silva, Guilherme Liberato Da, Chac��n-Hern��ndez, Julio Cesar, Silva, Onilda Santos Da, Ferla, Noeli Juarez, and Johann, Liana
Subjects: Arthropoda, Stigmaeidae, Arachnida, Prostigmata, Animalia, Biodiversity, Agistemus, Taxonomy
Abstract: Genus: Agistemus Summers, 1960 Type species: Caligonus terminalis Quayle, 1912, by original designation. Agistemus terminalis (Quayle), Summers, 1960: 234., Published as part of Monjar��s-Barrera, Jos�� Irving, Silva, Guilherme Liberato Da, Chac��n-Hern��ndez, Julio Cesar, Silva, Onilda Santos Da, Ferla, Noeli Juarez & Johann, Liana, 2020, A new species and new record of Agistemus Summers (Acari: Stigmaeidae) associated withCapsicum annuum L. var. glabriusculum (Solanaceae) from Northeastern of Mexico, pp. 470-480 in Acarologia 60 (2) on page 471, DOI: 10.24349/acarologia/20204378, http://zenodo.org/record/4488035, {"references":["Summers, F. M. 1960. Several stigmaeid mites formerly included in Mediolata redescribed in Zetzellia"]}
Published: 2020
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28. Multiple-aperture one-shot shearography for simultaneous measurements in three shearing directions

Author: Mauro Eduardo Benedet, Daniel Pedro Willemann, Armando Albertazzi Gonçalves, Estiven S. Barrera, and A. V. Fantin
Subjects: Shearing (physics), Materials science, Aperture, business.industry, Mechanical Engineering, Phase (waves), 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Wedge (geometry), Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, 010309 optics, Speckle pattern, symbols.namesake, Fourier transform, Optics, Shearography, Interference (communication), 0103 physical sciences, symbols, Electrical and Electronic Engineering, 0210 nano-technology, business
Abstract: A new shearography configuration was developed to simultaneously acquire images of a specimen in three different shearing directions, the proposed configuration is capable of performing measurements of shearography with multiple shearing directions using just one single interferogram. The device uses a three aperture mask and a single imaging lens to produce interference speckles with carrier fringes in three different directions. A set of three wedge prisms are used in combination with the three apertures to produce simultaneous shearing interferograms for three different orientations. A single high-resolution image of the specimen is captured for each loading level and the phase maps are computed by FTM (Fourier Transform Method). Additionally, as the device has no movable parts and just a single shot image is acquired, it is very compact, robust and can be successfully used outside the optical bench. The paper presents the optical setup and a practical application for the new technique.
Published: 2018
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29. QUANTIFICATION OF THE CONTRIBUTION OF FILLER CHARACTERISTICS TO NATURAL RUBBER REINFORCEMENT USING PRINCIPAL COMPONENT ANALYSIS

Author: Alfred B.O. Soboyejo, Cindy S. Barrera, and Katrina Cornish
Subjects: Materials science, Polymers and Plastics, media_common.quotation_subject, chemistry.chemical_element, 02 engineering and technology, engineering.material, 01 natural sciences, Natural rubber, Filler (materials), Linear regression, Materials Chemistry, Composite material, media_common, Variables, 010401 analytical chemistry, Regression analysis, Carbon black, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, visual_art, Principal component analysis, engineering, visual_art.visual_art_medium, 0210 nano-technology, Carbon
Abstract: Practical statistical models were developed to quantify individual contributions from characteristics of conventional and non-conventional fillers and predict resulting mechanical properties of both hevea and guayule natural rubber composites. Carbon black N330 and four different agro-industrial residues, namely, eggshells, carbon fly ash, processing tomato peels, and guayule bagasse, were used in this study. Filler characteristics were used as explanatory variables in multiple linear regression analyses. Principal component analysis was used to evaluate correlations among explanatory variables based on their correlation matrices and to transform them into a new set of independent variables, which were then used to generate reliable regression models. Surface area, dispersive component of surface energy, carbon black, and waste-derived filler loading were found to have almost equal importance in the prediction of composite properties. However, models developed for ultimate elongation poorly explained variability, indicating the dependence of this property on other variables. Agro-industrial residues could potentially serve as more sustainable fillers for polymer composites than conventional fillers. This new modeling approach for polymer composites allows the performance of a wide range of different waste-derived fillers to be predicted with minimum laboratory work, facilitating the optimization of compound recipes to address specific product requirements.
Published: 2018
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30. Tg/Hdl-C Ratio as Cardio-Metabolic Biomarker even in Normal Weight Women

Author: Alma Díaz, Nydia Cordova, F Avelar, S Barrera, L Sánchez, Lourdes Basurto, E González-Escudero, G Borrayo, G O Hernández-González, A Vázquez, and J A Degollado
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Adipose tissue, 030209 endocrinology & metabolism, Context (language use), 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Insulin resistance, High-density lipoprotein, Internal medicine, medicine, Case Series, Prediabetes, Endocrine and Autonomic Systems, business.industry, Insulin, Odds ratio, medicine.disease, chemistry, business, Body mass index
Abstract: Context Despite that the Triglycerides/High Density Lipoprotein Cholesterol (TG/HDL-C) ratio has been associated with insulin resistance and cardiovascular disease, some outcomes differ between populations. Objective The objective of this study was to evaluate the association between TG/HDL-C ratio and cardio-metabolic risk factors in both obese and normal weight women. Design Cross sectional, from January to December of 2015. Subjects and methods Two hundred and fifty three women aged 40 to 60 years. Anthropometric and laboratory measurements were performed. Insulin resistance was measured by the homeostasis model assessment for insulin resistance (HOMA-IR). All participants underwent a Doppler ultrasound to measure intima-media thickness of carotid artery (cIMT). Results TG/HDL-C ratio correlated with body mass index (r=0.194, p=0.01), and visceral adipose tissue (r=0.193, p=0.002). Additionally, TG/HDL-C correlated with glucose (r=0.367, p=0.001), insulin (r=0.354, p=0.001) and HOMA-IR (r=0.396 p=0.001). TG/HDL-C was associated with prediabetes, Odds Ratio (OR) was 1.83 (95%CI 1.07-3.13) and insulin resistance 3.27 (95%CI 1.78-6.01), and this risk remains in normal weight women 4.7 (95%CI 1.2-17.81) for prediabetes and 4.38 (95%CI 1.42-13.84) for insulin resistance. No significant risk for cIMT. Conclusion A TG/HDL-C ratio ≥ 3.0 is a potential risk factor for prediabetes and insulin resistance in women 40-60 years, even in normal weight women.
Published: 2018
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31. Processing and mechanical properties of natural rubber/waste-derived nano filler composites compared to macro and micro filler composites

Author: Cindy S. Barrera and Katrina Cornish
Subjects: Tear resistance, Materials science, Nanocomposite, biology, Composite number, 02 engineering and technology, Carbon black, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, Natural rubber, visual_art, Filler (materials), Ultimate tensile strength, visual_art.visual_art_medium, engineering, Composite material, 0210 nano-technology, Agronomy and Crop Science, Hevea
Abstract: Nano-sized fillers produced from renewable materials can generate high performance natural rubber (NR) composites while reducing dependency on petroleum. We made NR composites, with both hevea and guayule NR, containing nano-scale waste-derived fillers as complete and partial replacements of carbon black. The effect of nano-filler type and loading on composite mechanical properties was analyzed and compared to previous results with micro and macro fillers. Also, processability of the compounds was investigated. Reinforcement of both NRs was achieved by nano-sized waste-derived fillers, even with complete replacement of carbon black. Increases of up to 2.4 and 1.8 times higher tensile and tear strength, respectively, were achieved in some of the composites compared to the unfilled compound. Better relative reinforcement was obtained in guayule than in hevea rubber due to different rubber macromolecular structure and the strength of the rubber-waste filler interactions. Composites containing waste-derived fillers as co-fillers with carbon black displayed uncommon combinations of properties not achieved with single conventional reinforcing fillers. Furthermore, significant reductions in power consumption during mixing, up to 10% in hevea and 19% in guayule composites, were obtained even by replacement of a small portion of carbon black in the composites. Despite increased interest in nano-sized particles, micro-sized fillers are effective reinforcing fillers when used as partial replacements of carbon black, and can be produced at a much lower cost than nano-sized particles.
Published: 2017
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32. Developing fluency in writing: How features of speech can support acts of writing

Author: Estanislado S. Barrera
Subjects: Linguistics and Language, Journal entry, Orality, 05 social sciences, 050301 education, Context (language use), Language and Linguistics, Linguistics, Education, Fluency, Argument, 0502 economics and business, Meaning-making, Club, Psychology, 0503 education, 050203 business & management, Meaning (linguistics)
Abstract: Grounded in the work of Ong’s (1982) theory of the ‘internalization of the technology of writing’ (p. 437), this study sought to understand the application of oral language skills to writing. Contextualized in a South Texas urban setting, five elementary students participated in an after-school book club over the course of six months. During this time, the participants engaged in discursive activities in the form of response sheets, discussions, communal meaning statements, and reflective journal entries. Using seminal research by Elbow (1985) that supports how writing is similar to speech, findings showed that seven of the nine characteristic features of speech were also evident in the writing acts engaged by the participants. Those characteristics were: spontaneity; responding, replying, and two-way communication; voice, participation in meaning making; and organization and structure. This context for writing removed many of the threats commonly associated with the traditional unidirectional approach to writing. Overall, the participants merged the speech acts into the writing acts, moving seamlessly through the processes of communication.
Published: 2017
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33. Culturally Responsive Literacy Practices in an Early Childhood Community

Author: Estanislado S. Barrera, Susan V. Bennett, Guda Gayle-Evans, AnnMarie Alberton Gunn, and Cynthia B. Leung
Subjects: Early childhood education, media_common.quotation_subject, Multicultural education, 05 social sciences, 050301 education, Context (language use), Literacy, Education, Critical literacy, Cultural diversity, Pedagogy, Developmental and Educational Psychology, 0501 psychology and cognitive sciences, Sociology, Early childhood, 0503 education, Cultural pluralism, 050104 developmental & child psychology, media_common
Abstract: Early childhood educators continue to see an increase in their culturally diverse student population. As our country continues to grow as a multicultural nation, it is imperative that our early childhood classrooms embrace this rich diversity and provide experiences that affirm all students, families and communities. We (teacher educators) synthesized the current research into the following five frameworks that we believe embody the foundation of culturally responsive teaching (CRT) in an early childhood setting: (a) developing a culturally responsive classroom community, (b) family engagement, (c) critical literacy within a social justice framework, (d) multicultural literature, and (e) culturally responsive print rich environments. In this article we situate each framework within the larger context of research. Next we move beyond discussing CRT practices by offering ideas on how culturally responsive classrooms look and how to implement this pedagogy and in an early childhood setting with real classroom practices.
Published: 2017
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34. Search for a heavy Higgs boson decaying to a pair of W bosons in proton-proton collisions at root s=13 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Brandstetter, J. Dragicevic, M. Eroe, J. and Del Valle, A. Escalante Flechl, M. Fruehwirth, R. Jeitler, M. Krammer, N. Kraetschmer, I. Liko, D. Madlener, T. and Mikulec, I. Rad, N. Schieck, J. Schoefbeck, R. Spanring, M. Spitzbart, D. Waltenberger, W. Wulz, C. -E. Zarucki, M. Drugakov, V. Mossolov, V. Gonzalez, J. Suarez and Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. and Lauwers, J. Lelek, A. Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. D'Hondt, J. and De Clercq, J. Lontkovskyi, D. Lowette, S. Marchesini, I. and Moortgat, S. Moreels, L. Python, Q. Skovpen, K. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. and Beghin, D. Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. Favart, L. and Grebenyuk, A. Kalsi, A. K. Luetic, J. Popov, A. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. and Vannerom, D. Cornelis, T. Dobur, D. Khvastunov, I. and Niedziela, M. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bondu, O. and Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. and Giammanco, A. Lemaitre, V. Magitteri, A. Prisciandaro, J. Saggio, A. Marono, M. Vidal Vischia, P. Zobec, J. and Alves, F. L. Alves, G. A. Silva, G. Correia Hensel, C. and Moraes, A. Teles, P. Rebello Batista Das Chagas, E. Belchior and Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. and Da Silveira, G. G. Damiao, D. De Jesus Martins, C. De Oliveira and De Souza, S. Fonseca Huertas Guativa, L. M. Malbouisson, H. and Martins, J. Figueiredo, D. Matos Jaime, M. Medina De Almeida, M. Melo Herrera, C. Mora Mundim, L. Nogima, H. and Prado Da Silva, W. L. Sanchez Rosas, L. J. Santoro, A. and Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Da Silva De Araujo, F. Torres Pereira, A. Vilela Ahuja, S. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Lemos, D. S. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. and Iaydjiev, P. Marinov, A. Misheva, M. Rodozov, M. and Shopova, M. Sultanov, G. Bonchev, M. Dimitrov, A. and Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Fang, W. and Gao, X. Yuan, L. Ahmad, M. Chen, G. M. Chen, H. S. and Chen, M. Jiang, C. H. Leggat, D. Liao, H. Liu, Z. and Shaheen, S. M. Spiezia, A. Tao, J. Yazgan, E. Zhang, H. and Zhang, S. Zhao, J. Agapitos, A. Ban, Y. Chen, G. and Levin, A. Li, J. Li, L. Li, Q. Mao, Y. Qian, S. J. and Wang, D. Wang, Q. Hu, Z. Wang, Y. Avila, C. and Cabrera, A. Sierra, L. F. Florez, C. Hernandez, C. F. Gonzalez Delgado, M. A. Segura Guisao, J. Mejia Alvarez, J. D. Ruiz Gonzalez, C. A. Salazar Arbelaez, N. Vanegas and Giljanovic, D. Godinovic, N. Lelas, D. Puljak, I. and Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V. Ceci, S. Ferencek, D. Kadija, K. Mesic, B. Roguljic, M. and Starodumov, A. Susa, T. Ather, M. W. Attikis, A. and Erodotou, E. Ioannou, A. Kolosova, M. Konstantinou, S. and Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. and Razis, P. A. Rykaczewski, H. Tsiakkouri, D. Finger, M. and Finger, Jr., M. Kveton, A. Tomsa, J. Ayala, E. Jarrin, E. Carrera Abdalla, H. Salama, E. Bhowmik, S. De Oliveira, A. Carvalho Antunes Dewanjee, R. K. Ehataht, K. and Kadastik, M. Raidal, M. Veelken, C. Eerola, P. and Forthomme, L. Kirschenmann, H. Osterberg, K. Voutilainen, M. and Garcia, F. Havukainen, J. Heikkila, J. K. Jarvinen, T. and Karimaki, V. Kinnunen, R. Lampen, T. Lassila-Perini, K. and Laurila, S. Lehti, S. Linden, T. Luukka, P. Maenpaa, T. Siikonen, H. Tuominen, E. Tuominiemi, J. Tuuva, T. and Besancon, M. Couderc, F. Dejardin, M. Denegri, D. and Fabbro, B. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel Jarry, P. Leloup, C. Locci, E. Malcles, J. Rander, J. Rosowsky, A. and Sahin, M. O. Savoy-Navarro, A. Titov, M. Amendola, C. and Beaudette, F. Busson, P. Charlot, C. Diab, B. Falmagne, G. de Cassagnac, R. Kucher, I. Lobanov, A. Perez, C. and Nguyen, M. Ochando, C. Paganini, P. Rembser, J. Salerno, R. Sauvan, J. B. Sirois, Y. Zabi, A. Zghiche, A. and Agram, J. -L. Andrea, J. Bloch, D. Bourgatte, G. Brom, J. -M. Chabert, E. C. Collard, C. Conte, E. Fontaine, J. -C. Gele, D. Goerlach, U. Jansova, M. Le Bihan, A. -C. and Tonon, N. Van Hove, P. Gadrat, S. Beauceron, S. and Bernet, C. Boudoul, G. Camen, C. Chanon, N. Chierici, R. and Contardo, D. Depasse, P. El Mamouni, H. Fay, J. and Gascon, S. Gouzevitch, M. Ille, B. Jain, Sa. Lagarde, F. and Laktineh, I. B. Lattaud, H. Lethuillier, M. Mirabito, L. and Perries, S. Sordini, V. Touquet, G. Vander Donckt, M. and Viret, S. Toriashvili, T. Tsamalaidze, Z. Autermann, C. and Feld, L. Kiesel, M. K. Klein, K. Lipinski, M. and Meuser, D. Pauls, A. Preuten, M. Rauch, M. P. and Schomakers, C. Schulz, J. Teroerde, M. Wittmer, B. and Albert, A. Erdmann, M. Erdweg, S. Esch, T. Fischer, B. and Fischer, R. Ghosh, S. Hebbeker, T. Hoepfner, K. and Keller, H. Mastrolorenzo, L. Merschmeyer, M. Meyer, A. and Millet, P. Mocellin, G. Mondal, S. Mukherjee, S. Noll, D. Novak, A. Pook, T. Pozdnyakov, A. Quast, T. and Radziej, M. Rath, Y. Reithler, H. Rieger, M. Roemer, J. and Schmidt, A. Schuler, S. C. Sharma, A. Thueer, S. and Wiedenbeck, S. Fluegge, G. Ahmad, W. Hlushchenko, O. and Kress, T. Mueller, T. Nehrkorn, A. Nowack, A. Pistone, C. Pooth, O. Roy, D. Sert, H. Stahl, A. Martin, M. and Asmuss, P. Babounikau, I. Bakhshiansohi, H. Beernaert, K. Behnke, O. Behrens, U. Martinez, A. Bertsche, D. and Bin Anuar, A. A. Borras, K. Botta, V. Campbell, A. and Cardini, A. Connor, P. Rodriguez, S. Contreras-Campana, C. and Danilov, V. De Wit, A. Defranchis, M. M. Pardos, C. and Damiani, D. Eckerlin, G. Eckstein, D. Eichhorn, T. and Elwood, A. Eren, E. Gallo, E. Geiser, A. Luyando, J. M. and Grohsjean, A. Guthoff, M. Haranko, M. Harb, A. and Jafari, A. Jomhari, N. Z. Jung, H. Kasem, A. Kasemann, M. Kaveh, H. Keaveney, J. Kleinwort, C. Knolle, J. and Kruecker, D. Lange, W. Lenz, T. Leonard, J. Lidrych, J. and Lipka, K. Lohmann, W. Mankel, R. Melzer-Pellmann, I. -A. and Meyer, A. B. Meyer, M. Missiroli, M. Mittag, G. and Mnich, J. Mussgiller, A. Myronenko, V. Adan, D. and Pflitsch, S. K. Pitzl, D. Raspereza, A. Saibel, A. and Savitskyi, M. Scheurer, V. Schuetze, P. Schwanenberger, C. and Shevchenko, R. Singh, A. Tholen, H. Turkot, O. and Vagnerini, A. van de Klundert, M. Van Onsem, G. P. Walsh, R. and Wen, Y. Wichmann, K. Wissing, C. Zenaiev, O. and Zlebcik, R. Aggleton, R. Bein, S. Benato, L. Benecke, A. and Blobel, V. Dreyer, T. Ebrahimi, A. Froehlich, A. and Garbers, C. Garutti, E. Gonzalez, D. Gunnellini, P. and Haller, J. Hinzmann, A. Karavdina, A. Kasieczka, G. and Klanner, R. Kogler, R. Kovalchuk, N. Kurz, S. Kutzner, V. Lange, J. Lange, T. Malara, A. Marconi, D. and Multhaup, J. Niemeyer, C. E. N. Nowatschin, D. Perieanu, A. and Reimers, A. Rieger, O. Scharf, C. Schleper, P. and Schumann, S. Schwandt, J. Sonneveld, J. Stadie, H. and Steinbrueck, G. Stober, F. M. Stoever, M. Vormwald, B. and Zoi, I. Akbiyik, M. Barth, C. Baselga, M. Baur, S. and Berger, T. Butz, E. Caspart, R. Chwalek, T. De Boer, W. and Dierlamm, A. El Morabit, K. Faltermann, N. Giffels, M. and Goldenzweig, P. Gottmann, A. Harrendorf, M. A. Hartmann, F. Husemann, U. Kudella, S. Mitra, S. Mozer, M. U. and Mueller, Th. Musich, M. Nuernberg, A. Quast, G. and Rabbertz, K. Schroeder, M. Shvetsov, I. Simonis, H. J. and Ulrich, R. Weber, M. Woehrmann, C. Wolf, R. Anagnostou, G. Asenov, P. Daskalakis, G. Geralis, T. Kyriakis, A. and Loukas, D. Paspalaki, G. Diamantopoulou, M. and Karathanasis, G. Kontaxakis, P. Panagiotou, A. Papavergou, I. Saoulidou, N. Stakia, A. Theofilatos, K. Vellidis, K. and Bakas, G. Kousouris, K. Papakrivopoulos, I. Tsipolitis, G. Evangelou, I. Foudas, C. Gianneios, P. Katsoulis, P. and Kokkas, P. Mallios, S. Manitara, K. Manthos, N. and Papadopoulos, I. Strologas, J. Triantis, F. A. Tsitsonis, D. and Bartok, M. Csanad, M. Major, P. Mandal, K. Mehta, A. and Nagy, M. I. Pasztor, G. Suranyi, O. Veres, G. I. and Bencze, G. Hajdu, C. Horvath, D. Sikler, F. Vami, T. a. and Veszpremi, V. Vesztergombi, G. Beni, N. Czellar, S. and Karancsi, J. Makovec, A. Molnar, J. Szillasi, Z. Raics, P. Teyssier, D. Trocsanyi, Z. L. Ujvari, B. Csorgo, T. and Metzger, W. J. Nemes, F. Novak, T. Choudhury, S. and Komaragiri, J. R. Tiwari, P. C. Bahinipati, S. Kar, C. and Kole, G. Mal, P. Bindhu, V. K. Nayak, A. Sahoo, D. K. and Swain, S. K. Bansal, S. Beri, S. B. Bhatnagar, V. and Chauhan, S. Chawla, R. Dhingra, N. Gupta, R. Kaur, A. and Kaur, M. Kaur, S. Kumari, P. Lohan, M. Meena, M. and Sandeep, K. Sharma, S. Singh, J. B. Virdi, A. K. Walia, G. Bhardwaj, A. Choudhary, B. C. Garg, R. B. Gola, M. and Keshri, S. Kumar, Ashok Malhotra, S. Naimuddin, M. and Priyanka, P. Ranjan, K. 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A. Odell, N. Schmitt, M. H. Sung, K. Trovato, M. Velasco, M. Bucci, R. Dev, N. Goldouzian, R. Hildreth, M. Anampa, K. Jessop, C. and Karmgard, D. J. Lannon, K. Li, W. Loukas, N. Marinelli, N. Mcalister, I. Meng, F. Mueller, C. Musienko, Y. and Planer, M. Ruchti, R. Siddireddy, P. Smith, G. Taroni, S. Wayne, M. Wightman, A. Wolf, M. Woodard, A. and Alimena, J. Bylsma, B. Durkin, L. S. Flowers, S. and Francis, B. Hill, C. Ji, W. Lefeld, A. Ling, T. Y. and Winer, B. L. Cooperstein, S. Dezoort, G. Elmer, P. and Hardenbrook, J. Haubrich, N. Higginbotham, S. and Kalogeropoulos, A. Kwan, S. Lange, D. Lucchini, M. T. and Luo, J. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. and Palmer, C. Piroue, P. Salfeld-Nebgen, J. Stickland, D. and Tully, C. Wang, Z. Malik, S. Norberg, S. Barker, A. and Barnes, V. E. Das, S. Gutay, L. Jones, M. Jung, A. W. and Khatiwada, A. Mahakud, B. Miller, D. H. Negro, G. and Neumeister, N. Peng, C. C. Piperov, S. Qiu, H. Schulte, J. F. Sun, J. Wang, F. Xiao, R. Xie, W. 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Kunori, S. and Lamichhane, K. Lee, S. W. Mengke, T. Muthumuni, S. and Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. Whitbeck, A. Greene, S. Gurrola, A. Janjam, R. Johns, W. and Maguire, C. Melo, A. Ni, H. Padeken, K. Romeo, F. and Sheldon, P. Tuo, S. Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. Cummings, G. Hirosky, R. and Joyce, M. Ledovskoy, A. Neu, C. Tannenwald, B. Wang, Y. and Wolfe, E. Xia, F. Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Buchanan, J. and Caillol, C. Carlsmith, D. Dasu, S. De Bruyn, I. Dodd, L. and Fiori, F. Galloni, C. Gomber, B. He, H. Herndon, M. and Herve, A. Hussain, U. Klabbers, P. Lanaro, A. and Loeliger, A. Long, K. Loveless, R. Sreekala, J. Ruggles, T. Savin, A. Sharma, V. Smith, W. H. Teague, D. and Trembath-reichert, S. Woods, N. The CMS collaboration
Subjects: High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: A search for a heavy Higgs boson in the mass range from 0.2 to 3.0 TeV, decaying to a pair of W bosons, is presented. The analysis is based on proton-proton collisions at = 13 TeV recorded by the CMS experiment at the LHC in 2016, corresponding to an integrated luminosity of 35.9 fb(-1). The W boson pair decays are reconstructed in the 2l2 nu and l nu 2q final states (with l = e or mu). Both gluon fusion and vector boson fusion production of the signal are considered. Interference effects between the signal and background are also taken into account. The observed data are consistent with the standard model (SM) expectation. Combined upper limits at 95% confidence level on the product of the cross section and branching fraction exclude a heavy Higgs boson with SM-like couplings and decays up to 1870 GeV. Exclusion limits are also set in the context of a number of two-Higgs-doublet model formulations, further reducing the allowed parameter space for SM extensions.
Published: 2020

35. Pharmacological Treatment for Aging: Are We There?

Author: O. S. Barrera-Vázquez and Juan Carlos Gomez-Verjan
Subjects: Biological pathway, Senescence, business.industry, Sarcopenia, Calorie restriction, Autophagy, medicine, Epigenetics, Functional decline, medicine.disease, business, Bioinformatics, Pharmacological treatment
Abstract: Human aging is known as a functional decline in the normal homeostatic and physiological processes of the body. Aging per se increases the risk to suffer several age-related diseases, such as neurodegenerative diseases, dementias, cardiovascular dysfunction, cancer, arthritis, sarcopenia, osteoporosis, among others. Recent advances in molecular biology have increased knowledge in some of the main biological pathways involved in this condition. Therefore, several targets have been revealed as the main interactors on such pathways, making possible to develop compounds with the capability to regulate these processes and diminish its effects. Among these compounds we found antioxidants, autophagy inducers, senolytics, calorie restriction mimetics, and epigenetic drugs. In this chapter, we discuss the most outstanding discoveries on pharmacological compounds that could be useful to reverse or diminish the effects of aging. Although the correct regulation of aging still seems to be far away, many of these compounds show quite promising results of a possible treatment.
Published: 2020
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36. Search for new neutral Higgs bosons through the H -> ZA ->l+l-bb<overbar> process in pp collisions at s=13 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Brandstetter, J. Dragicevic, M. Eroe, J. and Del Valle, A. Escalante Flechl, M. Fruehwirth, R. Jeitler, M. Krammer, N. Kraetschmer, I. Liko, D. Madlener, T. and Mikulec, I. Rad, N. Schieck, J. Schoefbeck, R. Spanring, M. Spitzbart, D. Waltenberger, W. Wulz, C. -E. Zarucki, M. Drugakov, V. Mossolov, V. Gonzalez, J. Suarez and Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. and Lauwers, J. Lelek, A. Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. D'Hondt, J. and De Clercq, J. Lontkovskyi, D. Lowette, S. Marchesini, I. and Moortgat, S. Moreels, L. Python, Q. Skovpen, K. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. and Beghin, D. Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. Favart, L. and Grebenyuk, A. Kalsi, A. K. Luetic, J. Popov, A. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. and Vannerom, D. Cornelis, T. Dobur, D. Khvastunov, I. and Niedziela, M. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bondu, O. and Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. and Giammanco, A. Lemaitre, V. Magitteri, A. Prisciandaro, J. Saggio, A. Marono, M. Vidal Vischia, P. Zobec, J. and Alves, F. L. Alves, G. A. Correia Silva, G. Hensel, C. and Moraes, A. Rebello Teles, P. Belchior Batista Das Chagas, E. and Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. and Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. and Fonseca De Souza, S. Huertas Guativa, L. M. Malbouisson, H. and Martins, J. Matos Figueiredo, D. Medina Jaime, M. Melo De Almeida, M. Mora Herrera, C. Mundim, L. Nogima, H. and Prado Da Silva, W. L. Sanchez Rosas, L. J. Santoro, A. and Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. Bernardes, C. A. Calligaris, L. 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Narayanan, S. Niu, X. Paus, C. Rankin, D. Roland, C. Roland, G. Shi, Z. and Stephans, G. S. F. Sumorok, K. Tatar, K. Velicanu, D. and Wang, J. Wang, T. W. Wyslouch, B. Benvenuti, A. C. and Chatterjee, R. M. Evans, A. Guts, S. Hansen, P. and Hiltbrand, J. Jain, Sh. Kalafut, S. Kubota, Y. Lesko, Z. and Mans, J. Rusack, R. Wadud, M. A. Acosta, J. G. and Oliveros, S. Bloom, K. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. Suarez, R. Kamalieddin, R. Kravchenko, I. and Siado, J. E. Snow, G. R. Stieger, B. Agarwal, G. and Harrington, C. Iashvili, I. Kharchilava, A. Mclean, C. and Nguyen, D. Parker, A. Pekkanen, J. Rappoccio, S. and Roozbahani, B. Alverson, G. Barberis, E. Freer, C. and Haddad, Y. Hortiangtham, A. Madigan, G. Morse, D. M. and Orimoto, T. Skinnari, L. Tishelman-Charny, A. Wamorkar, T. and Wang, B. Wisecarver, A. Wood, D. Bhattacharya, S. and Bueghly, J. Gunter, T. Hahn, K. A. Odell, N. Schmitt, M. H. Sung, K. Trovato, M. Velasco, M. Bucci, R. Dev, N. Goldouzian, R. 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Volobouev, I. Wang, Z. Whitbeck, A. Greene, S. Gurrola, A. Janjam, R. Johns, W. and Maguire, C. Melo, A. Ni, H. Padeken, K. Romeo, F. and Sheldon, P. Tuo, S. Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. Cummings, G. Hirosky, R. and Joyce, M. Ledovskoy, A. Neu, C. Tannenwald, B. Wang, Y. and Wolfe, E. Xia, F. Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Buchanan, J. and Caillol, C. Carlsmith, D. Dasu, S. De Bruyn, I. Dodd, L. and Fiori, F. Galloni, C. Gomber, B. He, H. Herndon, M. and Herve, A. Hussain, U. Klabbers, P. Lanaro, A. and Loeliger, A. Long, K. Loveless, R. Sreekala, J. Ruggles, T. Savin, A. Sharma, V. Smith, W. H. Teague, D. and Trembath-reichert, S. Woods, N. CMS Collaboration
Subjects: High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: This paper reports on a search for an extension to the scalar sector of the standard model, where a new CP-even (odd) boson decays to a Z boson and a lighter CP-odd (even) boson, and the latter further decays to a b quark pair. The Z boson is reconstructed via its decays to electron or muon pairs. The analysed data were recorded in proton-proton collisions at a center-of-mass energy s = 13 TeV, collected by the CMS experiment at the LHC during 2016, corresponding to an integrated luminosity of 35.9 fb(-1). Data and predictions from the standard model are in agreement within the uncertainties. Upper limits at 95% confidence level are set on the production cross section times branching fraction, with masses of the new bosons up to 1000 GeV. The results are interpreted in the context of the two-Higgs-doublet model.
Published: 2020

37. Microbiome Research and Aging

Author: O. S. Barrera-Vázquez, M. F. Carrillo-Vega, and B. P. Chávez-Elizalde
Subjects: Host (biology), Human microbiome, Computational biology, Microbiome, Biology
Abstract: The human microbiome represents a growing area of research that integrates the biomedical and clinical sciences. Through the biomedical research, depth understanding of the molecular characteristics of the host and the microbiota has arisen. The clinical and epidemiological research allows the understanding of the interactions between the host and the microbiota over time.
Published: 2020
Full Text: View/download PDF

38. Search for charged Higgs bosons decaying into a top and a bottom quark in the all-jet final state of pp collisions at root s=13 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Brandstetter, J. Dragicevic, M. Ero, J. Del Valle, A. Escalante Flechl, M. Fruhwirth, R. Jeitler, M. and Krammer, N. Kratschmer, I Liko, D. Madlener, T. Mikulec, I Rad, N. Schieck, J. Schofbeck, R. Spanring, M. and Spitzbart, D. Waltenberger, W. Wulz, C-E Zarucki, M. and Drugakov, V Mossolov, V Gonzalez, J. Suarez Darwish, M. R. and De Wolf, E. A. Di Croce, D. Janssen, X. Lelek, A. and Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. D'Hondt, J. De Clercq, J. Lontkovskyi, D. Lowette, S. Marchesini, I Moortgat, S. Python, Q. and Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. and Burns, D. Beghin, D. Bilin, B. Brun, H. Clerbaux, B. and De Lentdecker, G. Delannoy, H. Dorney, B. Favart, L. and Grebenyuk, A. Kalsi, A. K. Popov, A. Postiau, N. and Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. and Vannerom, D. Cornelis, T. Dobur, D. Khvastunov, I and Niedziela, M. Roskas, C. Tytgat, M. Verbeke, W. and Vermassen, B. Vit, M. Bondu, O. Bruno, G. Caputo, C. and David, P. Delaere, C. Delcourt, M. Giammanco, A. and Lemaitre, V Prisciandaro, J. Saggio, A. Marono, M. Vidal and Vischia, P. Zobec, J. Alves, F. L. Alves, G. A. Correia Silva, G. Hensel, C. Moraes, A. Rebello Teles, P. and Batista Das Chagas, E. Belchior Carvalho, W. Chinellato, J. and Coelho, E. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. and Huertas Guativa, L. M. Malbouisson, H. Martins, J. Matos Figueiredo, D. Medina Jaime, M. Melo De Almeida, M. Mora Herrera, C. Mundim, L. Nogima, H. Prado Silva, W. L. and Sanchez Rosas, L. J. Santoro, A. Sznajder, A. Thiel, M. and Tonelli Manganote, E. J. Da Silva De Araujo, F. Torres Vilela Pereira, A. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Novaes, S. F. Padula, Sandra S. Gregores, E. M. and Mercadante, P. G. 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Subjects: High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: A search for charged Higgs bosons (H-+/-) decaying into a top and a bottom quark in the all-jet final state is presented. The analysis uses LHC proton-proton collision data recorded with the CMS detector in 2016 at root s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). No significant excess is observed above the expected background. Model-independent upper limits at 95% confidence level are set on the product of the H-+/- production cross section and branching fraction in two scenarios. For production in association with a top quark, limits of 21.3 to 0.007 pb are obtained for H-+/- masses in the range of 0.2 to 3 TeV. Combining this with a search in leptonic final states results in improved limits of 9.25 to 0.005 pb. The complementary s-channel production of an H-+/- is investigated in the mass range of 0.8 to 3 TeV and the corresponding upper limits are 4.5 to 0.023 pb. These results are interpreted using different minimal supersymmetric extensions of the standard model.
Published: 2020

39. Measurement of top quark pair production in association with a Z boson in proton-proton collisions at s=13 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Brandstetter, J. Dragicevic, M. Eroe, J. and Del Valle, A. Escalante Flechl, M. Fruehwirth, R. Jeitler, M. Krammer, N. Kraetschmer, I. Liko, D. Madlener, T. and Mikulec, I. Rad, N. Schieck, J. Schoefbeck, R. Spanring, M. Spitzbart, D. Waltenberger, W. Wulz, C. -E. Zarucki, M. Drugakov, V. Mossolov, V. Gonzalez, J. Suarez and Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. and Lauwers, J. Lelek, A. Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. D'Hondt, J. and De Clercq, J. Lontkovskyi, D. Lowette, S. Marchesini, I. and Moortgat, S. Moreels, L. Python, Q. Skovpen, K. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. and Beghin, D. Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. Favart, L. and Grebenyuk, A. Kalsi, A. K. Luetic, J. Popov, A. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. and Vannerom, D. Cornelis, T. Dobur, D. Khvastunov, I. and Niedziela, M. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bondu, O. and Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. and Giammanco, A. Lemaitre, V. Magitteri, A. Prisciandaro, J. Saggio, A. Marono, M. Vidal Vischia, P. Zobec, J. and Alves, F. L. Alves, G. A. Correia Silva, G. Hensel, C. and Moraes, A. Rebello Teles, P. Belchior Batista Das Chagas, E. and Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. and Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. and Fonseca De Souza, S. Huertas Guativa, L. M. Malbouisson, H. and Martins, J. Matos Figueiredo, D. Medina Jaime, M. Melo De Almeida, M. Mora Herrera, C. Mundim, L. Nogima, H. and Prado Da Silva, W. L. Sanchez Rosas, L. J. Santoro, A. and Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. Bernardes, C. A. Calligaris, L. 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Hall, G. and Iles, G. James, T. Komm, M. Laner, C. Lyons, L. and Magnan, A. -M. Malik, S. Martelli, A. Milosevic, V. and Nash, J. Palladino, V. Pesaresi, M. Raymond, D. M. and Richards, A. Rose, A. Scott, E. Seez, C. Shtipliyski, A. and Stoye, M. Strebler, T. Summers, S. Tapper, A. and Uchida, K. Virdee, T. Wardle, N. Winterbottom, D. and Wright, J. Zecchinelli, A. G. Zenz, S. C. Cole, J. E. and Hobson, P. R. Khan, A. Kyberd, P. Mackay, C. K. Morton, A. Reid, I. D. Teodorescu, L. Zahid, S. Call, K. and Dittmann, J. Hatakeyama, K. Madrid, C. McMaster, B. and Pastika, N. Smith, C. Bartek, R. Dominguez, A. Uniyal, R. Buccilli, A. Cooper, S. I. Henderson, C. Rumerio, P. and West, C. Arcaro, D. Bose, T. Demiragli, Z. Gastler, D. Girgis, S. Pinna, D. Richardson, C. Rohlf, J. and Sperka, D. Suarez, I. Sulak, L. Zou, D. Benelli, G. and Burkle, B. Coubez, X. Cutts, D. Duh, Y. t. Hadley, M. and Hakala, J. Heintz, U. Hogan, J. M. Kwok, K. H. M. and Laird, E. Landsberg, G. Lee, J. Mao, Z. Narain, M. and Sagir, S. Syarif, R. Usai, E. Yu, D. Band, R. and Brainerd, C. Breedon, R. Sanchez, M. Chertok, M. Conway, J. Conway, R. Cox, P. T. Erbacher, R. Flores, C. and Funk, G. Jensen, F. Ko, W. Kukral, O. Lander, R. and Mulhearn, M. Pellett, D. Pilot, J. Shi, M. Stolp, D. and Taylor, D. Tos, K. Tripathi, M. Wang, Z. Zhang, F. and Bachtis, M. Bravo, C. Cousins, R. Dasgupta, A. Florent, A. Hauser, J. Ignatenko, M. Mccoll, N. Nash, W. A. and Regnard, S. Saltzberg, D. Schnaible, C. Stone, B. and Valuev, V. Burt, K. Clare, R. Gary, J. W. Shirazi, S. M. A. Hanson, G. Karapostoli, G. Kennedy, E. Long, O. R. and Negrete, M. Paneva, M. I. Si, W. Wang, L. Wei, H. and Wimpenny, S. Yates, B. R. Zhang, Y. Branson, J. G. and Chang, P. Cittolin, S. Derdzinski, M. Gerosa, R. and Gilbert, D. Hashemi, B. Klein, D. Krutelyov, V. Letts, J. Masciovecchio, M. May, S. Padhi, S. Pieri, M. and Sharma, V. Tadel, M. Wurthwein, F. Yagil, A. Della Porta, G. Amin, N. Bhandari, R. Campagnari, C. Citron, M. Dutta, V. Sevilla, M. Gouskos, L. Incandela, J. and Marsh, B. Mei, H. Ovcharova, A. Qu, H. Richman, J. and Sarica, U. Stuart, D. Wang, S. Yoo, J. Anderson, D. and Bornheim, A. Cerri, O. Dutta, I. Lawhorn, J. M. Lu, N. and Mao, J. Newman, H. B. Nguyen, T. Q. Pata, J. and Spiropulu, M. Vlimant, J. R. Xie, S. Zhang, Z. Zhu, R. Y. Andrews, M. B. Ferguson, T. Mudholkar, T. Paulini, M. and Sun, M. Vorobiev, I. Weinberg, M. Cumalat, J. P. and Ford, W. T. Johnson, A. MacDonald, E. Mulholland, T. and Patel, R. Perloff, A. Stenson, K. Ulmer, K. A. Wagner, S. R. Alexander, J. Chaves, J. Cheng, Y. Chu, J. and Datta, A. Frankenthal, A. Mcdermott, K. Mirman, N. and Patterson, J. R. Quach, D. Rinkevicius, A. Ryd, A. Tan, S. M. Tao, Z. Thom, J. Wittich, P. Zientek, M. and Abdullin, S. Albrow, M. Alyari, M. Apollinari, G. and Apresyan, A. Apyan, A. Banerjee, S. Bauerdick, L. A. T. and Beretvas, A. Berryhill, J. Bhat, P. C. Burkett, K. and Butler, J. N. Canepa, A. Cerati, G. B. Cheung, H. W. K. and Chlebana, F. Cremonesi, M. Duarte, J. Elvira, V. D. and Freeman, J. Gecse, Z. Gottschalk, E. Gray, L. Green, D. and Grunendahl, S. Gutsche, O. Hall, AllisonReinsvold and Hanlon, J. Harris, R. M. Hasegawa, S. Heller, R. and Hirschauer, J. Jayatilaka, B. Jindariani, S. Johnson, M. and Joshi, U. Klima, B. Kortelainen, M. J. Kreis, B. Lammel, S. Lewis, J. Lincoln, D. Lipton, R. Liu, M. Liu, T. and Lykken, J. Maeshima, K. Marraffino, J. M. Mason, D. and McBride, P. Merkel, P. Mrenna, S. Nahn, S. O'Dell, V. and Papadimitriou, V. Pedro, K. Pena, C. Rakness, G. and Ravera, F. Ristori, L. Schneider, B. Sexton-Kennedy, E. and Smith, N. Soha, A. Spalding, W. J. Spiegel, L. Stoynev, S. Strait, J. Strobbe, N. Taylor, L. Tkaczyk, S. and Tran, N. V. Uplegger, L. Vaandering, E. W. Vernieri, C. and Verzocchi, M. Vidal, R. Wang, M. Weber, H. A. Acosta, D. and Avery, P. Bortignon, P. Bourilkov, D. Brinkerhoff, A. and Cadamuro, L. Carnes, A. Cherepanov, V. Curry, D. and Errico, F. Field, R. D. Gleyzer, S. V. Joshi, B. M. Kim, M. Konigsberg, J. Korytov, A. Lo, K. H. Ma, P. and Matchev, K. Menendez, N. Mitselmakher, G. Rosenzweig, D. and Shi, K. Wang, J. Wang, S. Zuo, X. Joshi, Y. R. and Adams, T. Askew, A. Hagopian, S. Hagopian, V. Johnson, K. F. Khurana, R. Kolberg, T. Martinez, G. Perry, T. and Prosper, H. Schiber, C. Yohay, R. Zhang, J. Baarmand, M. M. Bhopatkar, V. Hohlmann, M. Noonan, D. Rahmani, M. and Saunders, M. Yumiceva, F. Adams, M. R. Apanasevich, L. and Berry, D. Betts, R. R. Cavanaugh, R. Chen, X. Dittmer, S. Evdokimov, O. Gerber, C. E. Hangal, D. A. Hofman, D. J. Jung, K. Mills, C. Roy, T. Tonjes, M. B. Varelas, N. Wang, H. Wang, X. Wu, Z. Alhusseini, M. Bilki, B. and Clarida, W. Dilsiz, K. Durgut, S. Gandrajula, R. P. and Haytmyradov, M. Khristenko, V. Koseyan, O. K. Merlo, J. -P. and Mestvirishvili, A. Moeller, A. Nachtman, J. Ogul, H. and Onel, Y. Ozok, F. Penzo, A. Snyder, C. Tiras, E. and Wetzel, J. Blumenfeld, B. Cocoros, A. Eminizer, N. and Fehling, D. Feng, L. Gritsan, A. V. Hung, W. T. and Maksimovic, P. Roskes, J. Swartz, M. Xiao, M. Barrera, C. Baringer, P. Bean, A. Boren, S. Bowen, J. and Bylinkin, A. Isidori, T. Khalil, S. King, J. Krintiras, G. Kropivnitskaya, A. Lindsey, C. Majumder, D. Mcbrayer, W. Minafra, N. Murray, M. Rogan, C. Royon, C. and Sanders, S. Schmitz, E. Takaki, J. D. Wang, Q. Williams, J. Wilson, G. Duric, S. Ivanov, A. Kaadze, K. Kim, D. Maravin, Y. Mendis, D. R. Mitchell, T. Modak, A. and Mohammadi, A. Rebassoo, F. Wright, D. Baden, A. Baron, O. Belloni, A. Eno, S. C. Feng, Y. Hadley, N. J. and Jabeen, S. Jeng, G. Y. Kellogg, R. G. Kunkle, J. and Mignerey, A. C. Nabili, S. Ricci-Tam, F. Seidel, M. and Shin, Y. H. Skuja, A. Tonwar, S. C. Wong, K. and Abercrombie, D. Allen, B. Baty, A. Bi, R. Brandt, S. and Busza, W. Cali, I. A. D'Alfonso, M. Ceballos, G. and Goncharov, M. Harris, P. Hsu, D. Hu, M. Klute, M. and Kovalskyi, D. Lee, Y. -J. Luckey, P. D. Maier, B. and Marini, A. C. Mcginn, C. Mironov, C. Narayanan, S. Niu, X. Paus, C. Rankin, D. Roland, C. Roland, G. Shi, Z. and Stephans, G. S. F. Sumorok, K. Tatar, K. Velicanu, D. and Wang, J. Wang, T. W. Wyslouch, B. Benvenuti, A. C. and Chatterjee, R. M. Evans, A. Guts, S. Hansen, P. and Hiltbrand, J. Jain, Sh. Kalafut, S. Kubota, Y. Lesko, Z. and Mans, J. Rusack, R. Wadud, M. A. Acosta, J. G. and Oliveros, S. Bloom, K. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. Suarez, R. Kamalieddin, R. Kravchenko, I. and Siado, J. E. Snow, G. R. Stieger, B. Agarwal, G. and Harrington, C. Iashvili, I. Kharchilava, A. Mclean, C. and Nguyen, D. Parker, A. Pekkanen, J. Rappoccio, S. and Roozbahani, B. Alverson, G. Barberis, E. Freer, C. and Haddad, Y. Hortiangtham, A. Madigan, G. Morse, D. M. and Orimoto, T. Skinnari, L. Tishelman-Charny, A. Wamorkar, T. and Wang, B. Wisecarver, A. Wood, D. Bhattacharya, S. and Bueghly, J. Gunter, T. Hahn, K. A. Odell, N. Schmitt, M. H. Sung, K. Trovato, M. Velasco, M. Bucci, R. Dev, N. Goldouzian, R. Hildreth, M. Anampa, K. Jessop, C. and Karmgard, D. J. Lannon, K. Li, W. Loukas, N. Marinelli, N. Mcalister, I. Meng, F. Mueller, C. Musienko, Y. and Planer, M. Ruchti, R. Siddireddy, P. Smith, G. Taroni, S. Wayne, M. Wightman, A. Wolf, M. Woodard, A. and Alimena, J. Bylsma, B. Durkin, L. S. Flowers, S. and Francis, B. Hill, C. Ji, W. Lefeld, A. Ling, T. Y. and Winer, B. L. Cooperstein, S. Dezoort, G. Elmer, P. and Hardenbrook, J. Haubrich, N. Higginbotham, S. and Kalogeropoulos, A. Kwan, S. Lange, D. Lucchini, M. T. and Luo, J. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. and Palmer, C. Piroue, P. Salfeld-Nebgen, J. Stickland, D. and Tully, C. Wang, Z. Malik, S. Norberg, S. Barker, A. and Barnes, V. E. Das, S. Gutay, L. Jones, M. Jung, A. W. and Khatiwada, A. Mahakud, B. Miller, D. H. Negro, G. and Neumeister, N. Peng, C. C. Piperov, S. Qiu, H. Schulte, J. F. Sun, J. Wang, F. Xiao, R. Xie, W. Cheng, T. and Dolen, J. Parashar, N. Ecklund, K. M. Freed, S. and Geurts, F. J. M. Kilpatrick, M. Kumar, Arun Li, W. and Padley, B. P. Redjimi, R. Roberts, J. Rorie, J. Shi, W. and Leiton, A. G. Tu, Z. Zhang, A. Bodek, A. de Barbaro, P. Demina, R. Dulemba, J. L. Fallon, C. Ferbel, T. and Galanti, M. Garcia-Bellido, A. Han, J. Hindrichs, O. and Khukhunaishvili, A. Ranken, E. Tan, P. Taus, R. and Chiarito, B. Chou, J. P. Gandrakota, A. Gershtein, Y. and Halkiadakis, E. Hart, A. Heindl, M. Hughes, E. Kaplan, S. Kyriacou, S. Laflotte, I. Lath, A. Montalvo, R. and Nash, K. Osherson, M. Saka, H. Salur, S. Schnetzer, S. and Sheffield, D. Somalwar, S. Stone, R. Thomas, S. and Thomassen, P. Acharya, H. Delannoy, A. G. Heideman, J. and Riley, G. Spanier, S. Bouhali, O. Celik, A. Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. Eusebi, R. and Gilmore, J. Huang, T. Kamon, T. Luo, S. Marley, D. and Mueller, R. Overton, D. Pernie, L. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. De Guio, F. Kunori, S. and Lamichhane, K. Lee, S. W. Mengke, T. Muthumuni, S. and Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. Whitbeck, A. Greene, S. Gurrola, A. Janjam, R. Johns, W. and Maguire, C. Melo, A. Ni, H. Padeken, K. Romeo, F. and Sheldon, P. Tuo, S. Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. Cummings, G. Hirosky, R. and Joyce, M. Ledovskoy, A. Neu, C. Tannenwald, B. Wang, Y. and Wolfe, E. Xia, F. Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Buchanan, J. and Caillol, C. Carlsmith, D. Dasu, S. De Bruyn, I. Dodd, L. and Fiori, F. Galloni, C. Gomber, B. He, H. Herndon, M. and Herve, A. Hussain, U. Klabbers, P. Lanaro, A. and Loeliger, A. Long, K. Loveless, R. Sreekala, J. Ruggles, T. Savin, A. Sharma, V. Smith, W. H. Teague, D. and Trembath-reichert, S. Woods, N. CMS Collaboration
Subjects: High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: A measurement of the inclusive cross section of top quark pair production in association with a Z boson using proton-proton collisions at a center-of-mass energy of 13 TeV at the LHC is performed. The data sample corresponds to an integrated luminosity of 77.5 fb(-1), collected by the CMS experiment during 2016 and 2017. The measurement is performed using final states containing three or four charged leptons (electrons or muons), and the Z boson is detected through its decay to an oppositely charged lepton pair. The production cross section is measured to be sigma (ttZ) = 0.95 +/- 0.05 (stat) +/- 0.06 (syst) pb. For the first time, differential cross sections are measured as functions of the transverse momentum of the Z boson and the angular distribution of the negatively charged lepton from the Z boson decay. The most stringent direct limits to date on the anomalous couplings of the top quark to the Z boson are presented, including constraints on the Wilson coefficients in the framework of the standard model effective field theory.
Published: 2020

40. Integrative Outlooks About Clinical and Biomedical Research in Ageing

Author: O. S. Barrera-Vázquez, E. Delgado-de Anda, Carmen García-Peña, and Raúl Medina-Campos
Subjects: Ageing, business.industry, Pharmacogenomics, Identification (biology), Human genomics, Genomics, Computational biology, Personalized medicine, Proteomics, business
Abstract: Ageing is a highly complex biological process with multicausal features that encompass genetics, biology, and evolution. Advances in human genomics, proteomics, and pharmacogenomics have opened the path towards truly personalized medicine, with the identification of genes linked to diseases, the development of specifically targeted drugs, and the ability to associate specific genotypes with health conditions which can lead to a preventive or a predictive focus. This chapter is focused on analyzing the factors that influence ageing and lifespan, and it also presents different types of tools in genomics used in the research of ageing and its different applications in clinical scenarios, which have shown promising results for further research and development of effective evidence-based therapies for the treatment of diseases related to ageing.
Published: 2020
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41. Age-Related Neurodegenerative Diseases: An Update

Author: A. A. Guerrero-Cruz, Nadia Alejandra Rivero-Segura, and O. S. Barrera-Vázquez
Subjects: education.field_of_study, Parkinson's disease, business.industry, Population, Neurodegeneration, Disease, medicine.disease, Bioinformatics, Spinocerebellar ataxia, medicine, Dementia, Amyotrophic lateral sclerosis, business, education, Dysbiosis
Abstract: Neurodegenerative diseases (ND) are a large group of pathologies characterized by the progressive loss of selective neurons population with various factors that trigger their pathogenesis. With time the research about these increases exponentially, therefore, in the present chapter, we focus only on the most recent clinical biomarkers reported for ND such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Spinocerebellar ataxias (SCAs), and ischemic stroke that have age as a common risk factor. Since individuals become more vulnerable to develop some ND with age. Additionally, in the last section, we delve into the recent role of microbiota dysbiosis and probiotics consumption in age-related neurodegenerative diseases (ARND) and remark the importance of this relatively new and quite promising field for the development of new treatment strategies in the clinic.
Published: 2020
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42. ScribeMD: Mixed-methods analysis of a pen pal program in undergraduate medical education

Author: S. Barrera, J. Morrow, M. Garcia, J. Vargas, A. White, G. Kneese, A. Ryden, and J. Castillo
Subjects: Medical education, Students, Medical, Education, Medical, Humanism, MEDLINE, Humans, General Medicine, Psychology, Medical care, Mixed methods analysis, Education, Education, Medical, Undergraduate, Program Evaluation
Abstract: Introduction: A growing emphasis on humanistic medical care has led to the development of programs to imbue more humanistic values into training physicians. The ScribeMD intra-class pen pal program is a narrative medicine tool designed to meet this need with a focus on the journey through medical education. This study intends to evaluate the efficacy of this novel program on the participants’ professional identity formation (PIF), emotional intelligence development (EID), and narrative competency improvement (NCI). Methods: This program evaluation involved quantitative and qualitative survey solicitations from first and second-year medical student participants and controls. An efficacy-triangulation model was developed as a quantitative outcome-measuring tool linking objective, writing prompts, and survey data. Results: The quantitative results showed statistically significant improvements in line with the Efficacy Triangulation Model in the participant group. Qualitatively, reflective and insight-driven gains were elicited, as were notable themes of personal and community improvements. Conclusion:ScribeMD poses a unique avenue for the development of more humanistic physicians during their medical education. We recommend additional development of the Efficacy Triangulation Model as well as the program design itself. We also recommend the piloting of this program in other healthcare-education settings both with medical education and other health professions.
Published: 2019

43. A robust integration algorithm for out-of-plane displacement field measurements applied to multiple images of shearography

Author: Armando Albertazzi, Mauro Eduardo Benedet, A. V. Fantin, Daniel Pedro Willemann, and Estiven S. Barrera
Subjects: Shearing (physics), Interferometry, Speckle pattern, Shearography, Computer science, business.industry, Out of plane displacement, Acoustics, Integration algorithm, Minification, Aerospace, business
Abstract: Speckle shear interferometry, or shearography, has been more and more frequently used in the aerospace and oil and gas industry for in-field nondestructive inspections of flaws in composite materials. Nowadays new applications have emerged demanding the ability to operate in harsher environments, requiring more robust systems to meet this type of application. A recent modified shearography device allows multiple and simultaneous measurements with different shearing directions on a single grabbed image. This work proposes a robust integration algorithm by error minimization to obtain full-field displacement measurement. Simulated images are used to validate the effectiveness of the integration algorithm. Further, experiments are performed on a clamped circular plate with uniform loading. The proposed algorithm leads to a more accurate estimate of defect size measurement in composite materials.
Published: 2019
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44. Diameter quantification of through holes in pipelines hidden by protective layers of composite materials using instantaneous shearography simultaneously in three shearing directions

Author: Tiago Junior de Bortoli, Daniel Pedro Willemann, Estiven S. Barrera, Armando Albertazzi, A. V. Fantin, and Mauro Eduardo Benedet
Subjects: Shearing (physics), Pipeline transport, Materials science, Shearography, business.industry, Nondestructive testing, Glass fiber, Internal pressure, Composite material, Fibre-reinforced plastic, business, Finite element method
Abstract: Pipelines usually transport hydrocarbons in the oil and gas industry. Small amounts of salt water may be present, which can cause corrosion from the inside to outside. Severe corrosion may produce through holes in the pipe wall. External protective layers of fiber reinforced plastics has been applied to postpone the need to stop production to perform a definitive repair, but do not stop the internal corrosion. It is very important to monitor the dimensions of through holes hidden by the protective layers of composite materials, which cannot exceed critical size and compromise pipe safety. Classical methods, such as ultrasound, do not give very reliable answers when composite materials and steel are combined. There is a great demand for a reliable and practical in field non-destructive inspection method. This work brings a hybrid and reliable solution, which combines a new configuration of a portable one-shot shearography system with finite element methods, resulting in a portable and easy to apply solution. The paper describes the principle of the portable one-shot shearography system that is able of simultaneously measuring in three shearing directions[1]. Considerations and modeling of finite element to determine the response of the composite material to the variation of the internal pressure of the duct are discussed. The report details how the experimental data and numerical model results are combined through an iterative process to determine the diameter of the hidden hole. Instead of integrating the experimental results of shearography, the authors differentiate the results of finite element in the same directions as the one-shot shearography system does simultaneously. The minimum of the square error results in an estimation of the hidden hole diameter. Experiments were performed with 150 mm diameter tubes with 20 to 50 mm diameter holes hidden by 6 to 24 mm thick glass fiber reinforced plastic protective layers. Smaller thickness and bigger diameters led to better results. Mean deviations of the order of 10% were found for the whole set of tests. Although the authors consider it is possible to improve the results, deviations of the order of up to 10% are very acceptable results and represent a significant improvement over the classic methods used today. The robustness of the optical system, the ease of use of the algorithm and the level of uncertainty already achieved make the authors believe that the techniques developed here achieve the requirements and will be very useful for the oil and gas industry demands.
Published: 2019
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45. Impact damage characterization in CFRP plates using PCA and MEEMD decomposition methods in optical lock-in thermography phase images

Author: Bernardo Cassimiro Fonseca de Oliveira, Crhistian Raffaelo Baldo, Armando Albertazzi G., Robert Schmitt, Herberth Birck Fröhlich, and Estiven S. Barrera
Subjects: Computer science, business.industry, Noise (signal processing), Dimensionality reduction, Nondestructive testing, Feature extraction, Metric (mathematics), Principal component analysis, Pattern recognition, Image segmentation, Artificial intelligence, business, Hilbert–Huang transform
Abstract: Carbon fiber reinforced plastics (CFRP) are composite materials which are an interesting alternative to metal alloys in fields such as oil, aerospace, automotive, since CFRP have mechanical properties like metals but with a fraction of their weights. However, these materials have typically a highly anisotropic behavior, which may hinder the characterization of their integrity for example when subjected to an impact, because of its stochastic nature. Non-destructive testing (NDT) methods are interesting for integrity assessment, as they can evaluate the damage extension without affecting any part characteristics. Optical lock-in thermography (OLT) is an convenient NDT inspection alternative since it is a depth-wise method in which one can set different loading frequencies, leading to different scan depths. Pre-processing techniques like Principal Component Analysis (PCA) and Empirical Mode Decomposition (EMD) can be used to more accurately evaluate the damaged area. Their dimensionality reduction capability is highly desired as OLT images of CFRP laminates do not only show the defect, but also undesired information such as changes of background radiation, noise and the disposition of the fiber tissue. Traditional feature extraction methods must be highly tuned to obtain useful results. PCA and EMD methods may be considered non-supervised approaches, making them useful for a wide variety of inputs. However, PCA and EMD have their own natural limitations when being applied to images. While PCA may require high computational effort because of mathematical manipulation of matrices due to the mathematical manipulation of large matrices, problems due to mode superposition may occur if EMD original method is applied on images. In this sense, in this work it has been performed a comparison between PCA, with a new input vector architecture used to mitigate its problem with matrix dimensions, and a derivation of EMD method, called Multi-dimensional Ensemble Empirical Mode Decomposition (MEEMD), applied to prevent the previously mentioned superposition but without a higher computational effort, when segmenting OLT phase images. Outputs in both cases are binary masks with an estimation of the defect region, which were compared to a ground truth manually defined by a specialist. Matthews Correlation Coefficient (MCC) was chosen as segmentation comparison metric instead of F-score, since the last one does not take true negatives into account. The main difference during the application of PCA and MEEMD is that MEEMD yields two kinds of results, one for each frequency image and one average for the whole frequency set, whereas PCA gives only results in relation to the average. This study shown that PCA has better performance than MEEMD when the average results are compared, but MEEMD provides better results if onlt the best image per frequency set is used. Both PCA and MEEMD can yet provide interesting results for three-dimensional reconstruction with OLT images, thus further investigation of such techniques is desirable.
Published: 2019
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46. Should lower limb fractures be treated surgically in patients with chronic spinal injuries? Experience in a reference centre

Author: Sleiman Haddad, V. Molero, S. Rodríguez-Alabau, S. Barrera-Ochoa, J. Tomás, and Jordi Teixidor
Subjects: High rate, 030506 rehabilitation, medicine.medical_specialty, business.industry, 030209 endocrinology & metabolism, Spinal cord, Lower limb, Surgery, Conservative treatment, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Radiological weapon, medicine, Orthopedics and Sports Medicine, In patient, 0305 other medical science, Range of motion, business, Surgical treatment
Abstract: Objective To report the outcomes of surgical treatment of lower limb fractures in patients with chronic spinal cord injuries. Material and method A total of 37 lower limb fractures were treated from 2003 to 2010, of which 25 fractures were treated surgically and 12 orthopaedically. Results Patients of the surgical group had better clinical results, range of motion, bone consolidation, and less pressure ulcers and radiological misalignment. No differences were detected between groups in terms of pain, hospital stay, and medical complications. Discussion There is no currently consensus regarding the management of lower limb fractures in patients with chronic spinal cord injuries, but the trend has been conservative treatment due to the high rate of complications in surgical treatment. Conclusions Chronic spinal cord injuries patients with lower limb fractures who are treated surgically achieved a more reliable consolidation, practically a free range of motion, low rate of cutaneous complications, and pain associated with the fracture. This allows a quick return to the previous standard of living, and should be considered as an alternative to orthopaedic treatment in these patients.
Published: 2017
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47. ¿Se deben tratar quirúrgicamente las fracturas de extremidad inferior en pacientes con lesiones medulares crónicas? Experiencia en un centro de referencia

Author: J. Tomás, Sleiman Haddad, S. Rodríguez-Alabau, S. Barrera-Ochoa, Jordi Teixidor, and V. Molero
Subjects: 030506 rehabilitation, 03 medical and health sciences, 0302 clinical medicine, 030209 endocrinology & metabolism, Orthopedics and Sports Medicine, Surgery, 0305 other medical science
Abstract: Resumen Objetivo Conocer los resultados del tratamiento quirurgico de las fracturas de extremidad inferior en los pacientes con lesiones medulares cronicas. Material y metodo Entre el 2003-2012 se trataron 37 fracturas de extremidad inferior, divididas en 2 grupos segun su tratamiento, 25 en el grupo quirurgico y 12 en el grupo conservador. Resultados El grupo quirurgico presento mejores resultados en cuanto a balance articular, consolidacion osea, alineacion radiologica y menor numero de ulceras por presion. No se detectaron diferencias entre grupos en cuanto a estancia hospitalaria, numero de complicaciones medicas y control del dolor. Discusion Actualmente no hay consenso respecto al manejo de las fracturas de extremidad inferior en lesionados medulares cronicos, pero la tendencia ha sido el tratamiento conservador escudandose en la alta tasa de complicaciones del tratamiento quirurgico. Conclusiones En fracturas de extremidad inferior en lesionados medulares cronicos, la estabilizacion quirurgica presenta mejores resultados de consolidacion osea, un balance articular practicamente libre, una baja tasa de complicaciones cutaneas y dolor asociado a la fractura. Todo ello permite un rapido retorno al nivel previo de la lesion, por lo que se debe tener en cuenta como alternativa al tratamiento conservador.
Published: 2017
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48. High performance waste-derived filler/carbon black reinforced guayule natural rubber composites

Author: Cindy S. Barrera and Katrina Cornish
Subjects: Materials science, biology, Vulcanization, Modulus, 02 engineering and technology, Carbon black, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, Elastomer, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, law.invention, Natural rubber, law, Filler (materials), visual_art, Ultimate tensile strength, engineering, visual_art.visual_art_medium, Hevea brasiliensis, Composite material, 0210 nano-technology, Agronomy and Crop Science
Abstract: Guayule rubber (GNR) is an alternative source of natural rubber that does not crossreact with Type I latex allergy because it does not contain any proteins which can be recognized by antibodies raised against Hevea brasiliensis allergens. To advance the commercialization of this elastomer and diversify sources of natural rubber, efficient reinforcement of GNR is required to match the physical properties of vulcanized materials made from H. brasiliensise natural rubber in specific products. Superior or comparable reinforcement to that of carbon black N330, was achieved by partial replacement of carbon black with 5 and 10 phr of waste-derived material. Out of several waste-derived fillers tested, micro sized eggshells showed remarkable reinforcing potential for GNR. Hybrid carbon black/micro sized eggshells/GNR composites (up to 20 phr micro sized eggshells), had increased tensile strength, and elongation at break, while maintaining similar values of 300% modulus and hardness to those achieved by carbon black/GNR composites. Hierarchical cluster analysis partitioned the data into six groups of composites having statistically similar properties within each group. Composites containing 5–20 phr of micro sized eggshells were clustered in a separate group due to their unique combination of high tensile strength and flexibility. The superior reinforcement may reflect a combined synergistic reinforcing effect of carbon black particles, which possess a strong polymer-filler interaction, with the formation of a unique network between the GNR and the waste-derived materials, not attained with H. brasiliensis natural rubber.
Published: 2016
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49. Liquid guayule natural rubber, a renewable and crosslinkable processing aid in natural and synthetic rubber compounds

Author: Xianjie Ren, Cindy S. Barrera, Katrina Cornish, Andres Gil, and Janice Lisa Tardiff
Subjects: Materials science, 020209 energy, Strategy and Management, 02 engineering and technology, Diluent, Industrial and Manufacturing Engineering, law.invention, Natural rubber, law, 0202 electrical engineering, electronic engineering, information engineering, Naphtha, 0505 law, General Environmental Science, biology, Renewable Energy, Sustainability and the Environment, 05 social sciences, Vulcanization, Building and Construction, Carbon black, Pulp and paper industry, biology.organism_classification, Synthetic rubber, Compounding, visual_art, 050501 criminology, visual_art.visual_art_medium, Hevea
Abstract: Liquid guayule natural rubber (LGNR) was produced by thermal degradation of guayule natural rubber and tested as a renewable alternative to naphthenic oil (NO) processing aid in natural rubber (Hevea and guayule rubber) and synthetic (styrene-butadiene) rubber composites filled with carbon black (CB). Processing oils are rubber additives commonly used to improve the processability of a compound. Most processing oils, like NO, are petroleum-based, and negatively impact the carbon footprint of the rubber industry. Moreover, these aids act as diluents that lower the mechanical performance of the resultant rubber products. The energy consumption of rubber compounding, mechanical properties and crosslinking networks of natural and synthetic rubber composites made with LGNR were characterized. LGNR effectively helped the compounds mix as demonstrated by 13–21% lower energy consumption compared to compounds mixed without processing aids. Moreover, unlike NO, LGNR acted as an active additive in the vulcanization reaction. Tensile strength, elongation at break, modulus at 100% strain and hardness increased when NO was replaced with LGNR in the compounds. The higher mechanical properties may be explained by additional crosslinking networks formed between LGNR and the rubber matrices and strong LGNR-CB interactions. LGNR, as a renewable processing aid, can address rising performance goals, and reduce carbon footprint for rubber products. In conclusion, LGNR provides the same benefits as conventional diluent processing aids, enhances the properties of the final material, and is produced from a renewable plant source.
Published: 2020
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50. Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective

Author: Luis Miguel Gutiérrez-Robledo, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura, O. S. Barrera-Vázquez, and Omar Yaxmehen Bello-Chavolla
Subjects: Epigenomics, Proteomics, 0301 basic medicine, Aging, Process (engineering), Perspective (graphical), Computational biology, Chronological age, Biochemistry, World health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Neurology, Humans, Metabolomics, Multi omics, Microbiome, Psychology, Molecular Biology, Biomarkers, 030217 neurology & neurosurgery, Biotechnology
Abstract: The aging process has been linked to the occurrence of chronic diseases and functional impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and neurodegenerative diseases. Nonetheless, aging is highly variable and heterogeneous and represents a challenge for its characterization. In this sense, intrinsic capacity (IC) stands as a novel perspective by the World Health Organization, which integrates the individual wellbeing, environment, and risk factors to understand aging. However, there is a lack of quantitative and qualitative attributes to define it objectively. Therefore, in this review we attempt to summarize the most relevant and promising biomarkers described in clinical studies at date over different molecular levels, including epigenomics, transcriptomics, proteomics, metabolomics, and the microbiome. To aid gerontologists, geriatricians, and biomedical researchers to understand the aging process through the IC. Aging biomarkers reflect the physiological state of individuals and the underlying mechanisms related to homeostatic changes throughout an individual lifespan; they demonstrated that aging could be measured independently of time (that may explain its heterogeneity) and to be helpful to predict age-related syndromes and mortality. In summary, we highlight the areas of opportunity and gaps of knowledge that must be addressed to fully integrate biomedical findings into clinically useful tools and interventions.
Published: 2020
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