Search

Breakthroughs within the fields of genomics and bioinformatics have enabled the identification of numerous genetic biomarkers that reflect an individual's disease susceptibility, disease progression, and therapy responsiveness. The personalized medicine paradigm capitalizes on these breakthroughs by utilizing an individual's genetic profile to guide treatment selection, dosing, and preventative care. However, integration of personalized medicine into routine clinical practice has been limited—in part—by a dearth of widely deployable, timely, and cost-effective genetic analysis tools. Fortunately, the last several decades have been characterized by tremendous progress with respect to the development of molecular point-of-care tests (POCTs). Advances in microfluidic technologies, accompanied by improvements and innovations in amplification methods, have opened new doors to health monitoring at the point-of-care. While many of these technologies were developed with rapid infectious disease diagnostics in mind, they are well-suited for deployment as genetic testing platforms for personalized medicine applications. In the coming years, we expect that these innovations in molecular POCT technology will play a critical role in enabling widespread adoption of personalized medicine methods. In this work, we review the current and emerging generations of point-of-care molecular testing platforms and assess their applicability toward accelerating the personalized medicine paradigm.

In this study, the data of pediatric diarrhea clinic of Gansu Provincial Maternal and Child Health Hospital from January 1, 2014 to December 31, 2018 and Tianshui First Hospital from January 1, 2015 to December 31, 2018 were collected. Standardized precipitation index (SPI) and meteorological drought composite index (MCI) were used as drought indicators. Quasi-Poisson generalized additive model was used to analyze the correlation between drought and pediatric diarrhea outpatient visits. During the study period, the dry days in Lanzhou city and Tianshui city were 298 and 379 days according to SPI-1, 303 and 398 days according to MCI, respectively. There were 57 147 and 18 703 cases of diarrhea in children aged 0-6 years in Gansu Provincial Maternal and Child Health Hospital and Tianshui First Hospital, respectively. MCI and SPI (SPI-1) based on monthly precipitation were negatively correlated with the number of pediatric diarrhea outpatients. Compared with the non-drought period, SPI-1 showed the strongest correlation between middle drought and pediatric diarrhea outpatients, with an increase of 13.4% (95%本研究收集了2014年1月1日—2018年12月31日甘肃省妇幼保健院和2015年1月1日—2018年12月31日天水市第一医院儿童腹泻病门诊数据，以标准化降水指数（SPI）和气象干旱综合指数（MCI）作为干旱指标，采用quasi-Poisson分布广义相加模型分析干旱与儿童腹泻门诊量的关联情况。研究期间，兰州市和天水市干旱天数依据SPI-1分别为298和379 d，依据MCI分别为303和398 d；甘肃省妇幼保健院和天水市第一医院0~6岁儿童腹泻门诊量分别57 147和18 703例。基于月降水量的SPI（SPI-1）和MCI与儿童腹泻门诊量呈负相关。与非干旱时期相比，依据SPI-1划分，中旱与儿童腹泻病门诊量关联性最强，兰州市和天水市儿童腹泻病门诊量分别增加了13.4%（95%

子宫内膜增生多见于育龄期妇女，常见症状为异常子宫出血。本文汇总、整理子宫内膜增生相关研究，总结子宫内膜增生的高危因素、临床表现、评估和诊断、病理分型、治疗、随访以及患者长期管理、宣教等方面的循证医学证据，建立本指南，旨在为临床医师提供规范方案，促进女性健康和生育功能保护。.

To evaluate the structural integrity of a type of solid rocket motor grain with a largely increased area ratio using free-loading modified double-base grain, the Schapery integral nonlinear viscoelastic constitutive equation with damage is derived, and the numerical simulation model of solid rocket motor grain is constructed. According to the mission profile of the grain during the equipment period, the numerical simulation research on the mechanical response characteristics of the grain under three typical working conditions, namely, platform vibration, underwater explosion impact, and ignition pressurization during the launch is carried out. The simulation results show that under the three typical working conditions, the grain will not produce structural damage and defects, and the mechanical response of the grain under the platform vibration and explosion impact load is far less than that under the launch ignition pressurization. The ignition pressurization should be considered in the grain structural integrity design of this type or similar structure solid rocket motor.

Impurities degrade tokamak plasma confinement by causing energy loss, diluting fuel concentration, and even terminating discharge in some extreme cases. Previously, the suppression effects of impurity accumulation due to on-axis electron cyclotron resonance heating (ECRH) have been studied on Experimental and Advanced Superconducting Tokamak (EAST) using extreme ultraviolet (EUV) spectroscopy. However, it is difficult to quantify changes in the tungsten (W) impurity profile since W-line emission in the EUV range cannot be easily resolved. X-ray crystal spectroscopy (XCS) is widely used to measure the ion temperature and rotation velocity of plasmas by using line emission in the soft X-ray range. In addition, the XCS can also be used to study the behavior of impurities. An in situ absolute intensity calibration of tangential XCS was conducted by analyzing calculations and measurements of bremsstrahlung radiation. After obtaining the calibration coefficient, the W44+-ion-density profiles were evaluated using Abel inversion operations and the spectral line of W XLV (W44+, 3.9095 Å). Thus, a direct observation of the W44+-impurity concentration suppressed by ECRH was accomplished. Such W44+-density profiles can be used in the future to analyze W transport in combination with impurity transport codes.

International audience; High-βθe (a ratio of the electron thermal pressure to the poloidal magnetic pressure) steady-state long-pulse plasmas with steep central electron temperature gradient are achieved in the Experimental Advanced Superconducting Tokamak. An intrinsic current is observed to be modulated by turbulence driven by the electron temperature gradient. This turbulent current is generated in the countercurrent direction and can reach a maximum ratio of 25% of the bootstrap current. Gyrokinetic simulations and experimental observations indicate that the turbulence is the electron temperature gradient mode (ETG). The dominant mechanism for the turbulent current generation is due to the divergence of ETG-driven residual flux of current. Good agreement has been found between experiments and theory for the critical value of the electron temperature gradient triggering ETG and for the level of the turbulent current. The maximum values of turbulent current and electron temperature gradient lead to the destabilization of an m/n =1/1 kink mode, which by counteraction reduces the turbulence level (m and n are the poloidal and toroidal mode number, respectively). These observations suggest that the self-regulation system including turbulence, turbulent current, and kink mode is a contributing mechanism for sustaining the steady-state long-pulse high-βθe regime

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.--Full list of authors: Barragan, O.; Armstrong, D. J.; Gandolfi, D.; Carleo, I; Vidotto, A. A.; D'Angelo, C. Villarreal; Oklopcic, A.; Isaacson, H.; Oddo, D.; Collins, K.; Fridlund, M.; Sousa, S. G.; Persson, C. M.; Hellier, C.; Howell, S.; Howard, A.; Redfield, S.; Eisner, N.; Georgieva, I. Y.; Dragomir, D.; Bayliss, D.; Nielsen, L. D.; Klein, B.; Aigrain, S.; Zhang, M.; Teske, J.; Twicken, J. D.; Jenkins, J.; Esposito, M.; Van Eylen, V.; Rodler, F.; Adibekyan, V; Alarcon, J.; Anderson, D. R.; Murphy, J. M. Akana; Barrado, D.; Barros, S. C. C.; Benneke, B.; Bouchy, F.; Bryant, E. M.; Butler, R. P.; Burt, J.; Cabrera, J.; Casewell, S.; Chaturvedi, P.; Cloutier, R.; Cochran, W. D.; Crane, J.; Crossfield, I; Crouzet, N.; Collins, K., I; Dai, F.; Deeg, H. J.; Deline, A.; Demangeon, O. D. S.; Dumusque, X.; Figueira, P.; Furlan, E.; Gnilka, C.; Goad, M. R.; Goffo, E.; Gutierrez-Canales, F.; Hadjigeorghiou, A.; Hartman, Z.; Hatzes, A. P.; Harris, M.; Henderson, B.; Hirano, T.; Hojjatpanah, S.; Hoyer, S.; Kabath, P.; Korth, J.; Lillo-Box, J.; Luque, R.; Marmier, M.; Mocnik, T.; Muresan, A.; Murgas, F.; Nagel, E.; Osborne, H. L. M.; Osborn, A.; Osborn, H. P.; Palle, E.; Raimbault, M.; Ricker, G. R.; Rubenzahl, R. A.; Stockdale, C.; Santos, N. C.; Scott, N.; Schwarz, R. P.; Shectman, S.; Seager, S.; Segransan, D.; Serrano, L. M.; Skarka, M.; Smith, A. M. S.; Subjak, J.; Tan, T. G.; Udry, S.; Watson, C.; Wheatley, P. J.; West, R.; Winn, J. N.; Wang, S. X.; Wolfgang, A.; Ziegler, C.; KESPRINT Team., We present the discovery and characterization of two transiting planets observed by TESS in the light curves of the young and bright (V = 9.67) star HD73583 (TOI-560). We perform an intensive spectroscopic and photometric space- and ground-based follow-up in order to confirm and characterize the system. We found that HD73583 is a young (∼500 Myr) active star with a rotational period of 12.08 ± 0.11 d, and a mass and radius of 0.73 ± 0.02 M⊙ and 0.65 ± 0.02 R⊙, respectively. HD 73583 b (Pb = 6.3980420+0.0000067−0.0000062 d) has a mass and radius of 10.2+3.4−3.1 M⊕ and 2.79 ± 0.10 R⊕, respectively, which gives a density of 2.58+0.95−0.81 gcm−3⁠. HD 73583 c (Pc = 18.87974+0.00086−0.00074 d) has a mass and radius of 9.7+1.8−1.7 M⊕ and 2.39+0.10−0.09 R⊕, respectively, which translates to a density of 3.88+0.91−0.80 gcm−3⁠. Both planets are consistent with worlds made of a solid core surrounded by a volatile envelope. Because of their youth and host star brightness, they both are excellent candidates to perform transmission spectroscopy studies. We expect ongoing atmospheric mass-loss for both planets caused by stellar irradiation. We estimate that the detection of evaporating signatures on H and He would be challenging, but doable with present and future instruments. © The Author(s) 2022. Published by Oxford University Press on behalf of Royal Astronomical Society., This work was supported by the KESPRINT collaboration, an international consortium devoted to the characterization and research of exoplanets discovered with space-based missions (http://www.kesprint.science). We thank the referee for their helpful comments and suggestions that improved the quality of this manuscript. We acknowledge the use of public TESS data from pipelines at the TESS Science Office and at the TESS Science Processing Operations Center. Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center for the production of the SPOC data products. This work uses observations from the LCOGT network. Part of the LCOGT telescope time was granted by NOIRLab through the Mid-Scale Innovations Program (MSIP). MSIP is funded by NSF. This paper is in part based on data collected under the NGTS project at the ESO La Silla Paranal Observatory. The NGTS facility is operated by the consortium institutes with support from the UK Science and Technology Facilities Council (STFC) projects ST/M001962/1 and ST/S002642/1. This research has used the NASA Exoplanet Archive, which is operated by the California Institute of Technology, under contract with the National Aeronautics and Space Administration under the Exoplanet Exploration Program. Some of the observations in the paper used the High-Resolution Imaging instrument Zorro obtained under Gemini LLP Proposal Number: GN/S-2021A-LP-105. Zorro was funded by the NASA Exoplanet Exploration Program and built at the NASA Ames Research Center by Steve B. Howell, Nic Scott, Elliott P. Horch, and Emmett Quigley. Zorro was mounted on the Gemini North (and/or South) telescope of the international Gemini Observatory, a program of NSF’s OIR Lab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation on behalf of the Gemini partnership: the National Science Foundation (United States), National Research Council (Canada), Agencia Nacional de Investigación y Desarrollo (Chile), Ministerio de Ciencia, Tecnología e Innovación (Argentina), Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brazil), and Korea Astronomy and Space Science Institute (Republic of Korea). OB, BK, and SA acknowledge that this publication is part of a project that has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 865624). DG and LMS gratefully acknowledge financial support from the Cassa di Risparmio di Torino foundation under Grant No. 2018.2323 ‘Gaseous or rocky? Unveiling the nature of small worlds’. DJA acknowledges support from the STFC via an Ernest Rutherford Fellowship (ST/R00384X/1). APH and ME acknowledges grant HA 3279/12-1 within the DFG Schwerpunkt SPP 1992, ‘Exploring the Diversity of Extrasolar Planets’. JS and PK would like to acknowledge support from MSMT grant LTT-20015. We acknowledges the support by FCT – Fundação para a Ciência e a Tecnologia through national funds and by FEDER through COMPETE2020 – Programa Operacional Competitividade e Internacionalização by these grants: UID/FIS/04434/2019; UIDB/04434/2020; UIDP/04434/2020; PTDC/FIS-AST/32113/2017 & POCI-01-0145-FEDER-032113; PTDC/FISAST /28953/2017 & POCI-01-0145-FEDER-028953. AD acknowledges the financial support of the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (project FOUR ACES; grant agreement No 724427). AD also acknowledges financial support of the the Swiss National Science Foundation (SNSF) through the National Centre for Competence in Research ‘PlanetS’. MF, IYG, JK, and CMP gratefully acknowledge the support of the Swedish National Space Agency (DNR 177/19, 174/18, 2020-00104, 65/19). FGC thanks the Mexican national council for science and technology (CONACYT, CVU-1005374). MS acknowledge financial support of the Inter-transfer grant no LTT-20015. JL-B acknowledges financial support received from ‘la Caixa’ Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 847648, with fellowship code LCF/BQ/PI20/11760023. AAV acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 817540, ASTROFLOW). JMAM is supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1842400. JMAM acknowledges the LSSTC Data Science Fellowship Program, which is funded by LSSTC, NSF Cybertraining Grant No. 1829740, the Brinson Foundation, and the Moore Foundation; his participation in the program has benefited this work. RAR is supported by the NSF Graduate Research Fellowship, grant No. DGE 1745301. RL acknowledges financial support from the Spanish Ministerio de Ciencia e Innovación, through project PID2019-109522GB-C52, and the Centre of Excellence ‘Severo Ochoa’ award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). PC acknowledges the generous support from Deutsche Forschungsgemeinschaft (DFG) of the grant CH 2636/1-1. SH acknowledges CNES funding through the grant 837319. VA acknowledges the support from Fundação para a Ciência e Tecnologia (FCT) through Investigador FCT contract nr. IF/00650/2015/CP1273/CT0001. ODSD is supported in the form of work contract (DL 57/2016/CP1364/CT0004) funded by national funds through Fundação para a Ciência e Tecnologia (FCT). AO is supported by an STFC studentship. XD would like to acknowledge the funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement SCORE No 851555). HJD acknowledges support from the Spanish Research Agency of the Ministry of Science and Innovation (AEI-MICINN) under the grant ‘Contribution of the IAC to the PLATO Space Mission’ with reference PID2019-107061GB-C66, DOI: 10.13039/501100011033. DD acknowledges support from the TESS Guest Investigator Program grant 80NSSC19K1727 and NASA Exoplanet Research Program grant 18-2XRP18_2-0136. AO gratefully acknowledges support from the Dutch Research Council NWO Veni grant.

Full list of authors: Lillo-Box, J.; Gandolfi, D.; Armstrong, D. J.; Collins, K. A.; Nielsen, L. D.; Luque, R.; Korth, J.; Sousa, S. G.; Quinn, S. N.; Acuña, L.; Howell, S. B.; Morello, G.; Hellier, C.; Giacalone, S.; Hoyer, S.; Stassun, K.; Palle, E.; Aguichine, A.; Mousis, O.; Adibekyan, V.; Azevedo Silva, T.; Barrado, D.; Deleuil, M.; Eastman, J. D.; Fukui, A.; Hawthorn, F.; Irwin, J. M.; Jenkins, J. M.; Latham, D. W.; Muresan, A.; Narita, N.; Persson, C. M.; Santerne, A.; Santos, N. C.; Savel, A. B.; Osborn, H. P.; Teske, J.; Wheatley, P. J.; Winn, J. N.; Barros, S. C. C.; Butler, R. P.; Caldwell, D. A.; Charbonneau, D.; Cloutier, R.; Crane, J. D.; Demangeon, O. D. S.; Díaz, R. F.; Dumusque, X.; Esposito, M.; Falk, B.; Gill, H.; Hojjatpanah, S.; Kreidberg, L.; Mireles, I.; Osborn, A.; Ricker, G. R.; Rodriguez, J. E.; Schwarz, R. P.; Seager, S.; Serrano Bell, J.; Shectman, S. A.; Shporer, A.; Vezie, M.; Wang, S. X.; Zhou, G.--This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Context. The current architecture of a given multi-planetary system is a key fingerprint of its past formation and dynamical evolution history. Long-term follow-up observations are key to complete their picture. Aims. In this paper, we focus on the confirmation and characterization of the components of the TOI-969 planetary system, where TESS detected a Neptune-size planet candidate in a very close-in orbit around a late K-dwarf star. Methods. We use a set of precise radial velocity observations from HARPS, PFS, and CORALIE instruments covering more than two years in combination with the TESS photometric light curve and other ground-based follow-up observations to confirm and characterize the components of this planetary system. Results. We find that TOI-969 b is a transiting close-in (Pb ~ 1.82 days) mini-Neptune planet (mb = 9.1−1.0+1.1 M⊕, Rb = 2.765−0.097+0.088 R⊕), placing it on the lower boundary of the hot-Neptune desert (Teq,b = 941 ± 31 K). The analysis of its internal structure shows that TOI-969 b is a volatile-rich planet, suggesting it underwent an inward migration. The radial velocity model also favors the presence of a second massive body in the system, TOI-969 c, with a long period of Pc = 1700−280+290 days, a minimum mass of mc sin ic = 11.3−0.9+1.1 MJup, and a highly eccentric orbit of ec = 0.628−0.036+0.043. Conclusions. The TOI-969 planetary system is one of the few around K-dwarfs known to have this extended configuration going from a very close-in planet to a wide-separation gaseous giant. TOI-969 b has a transmission spectroscopy metric of 93 and orbits a moderately bright (G = 11.3 mag) star, making it an excellent target for atmospheric studies. The architecture of this planetary system can also provide valuable information about migration and formation of planetary systems. © The Authors 2023., J.L-B. acknowledges financial support received from “la Caixa” Foundation (ID 100010434) and from the European Unions Horizon 2020 research and innovation programme under the Marie Slodowska-Curie grant agreement No 847648, with fellowship code LCF/BQ/PI20/11760023. This research has also been partly funded by the Spanish State Research Agency (AEI) Projects No.PID2019-107061GB-C6l and No. MDM-2017-0737 Unidad de Excelencia “Maria de Maeztu” – Centro de Astrobiología (INTA-CSIC). R.L. acknowledges financial support from the Spanish Ministerio de Ciencia e Innovación, through project PID2019-109522GB-C52, and the Centre of Excellence “Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). DJ.A. acknowledges support from the STFC via an Ernest Rutherford Fellowship (ST/R00384X/1). S.G.S acknowledges the support from FCT through Estimulo FCT contract nr.CEECIND/00826/2018 and POPH/FSE (EC). G.M. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 895525. S.H. acknowledges CNES funding through the grant 837319. The French group acknowledges financial support from the French Programme National de Planétologie (PNP, INSU). This work is partly financed by the Spanish Mnistry of Economics and Competitiveness through grants PGC2018-098153-B-C31. We acknowledge the support by FCT – Fundação para a Ciência e a Tecnologia through national funds and by FEDER through COMPETE2020 – Programa Operacional Competitividade e Internacionalização by these grants: UID/FIS/04434/2019; UIDB/04434/2020; UIDP/04434/2020; PTDC/FIS-AST/32113/2017 & POCI-01-0145-FEDER-032113; PTDC/FISAST/28953/2017 & POCI-01-0145-FEDER-028953. P.J.W is supported by an STFC consolidated grant (ST/T000406/1). F.H. is funded by an STFC studentship. T.A.S acknowledges support from the Fundação para a Ciência e a Tecnologia (FCT) through the Fellowship PD/BD/150416/2019 and POCH/FSE (EC). C.M.P. acknowledges support from the SNSA (dnr 65/19P). This work has been carried out within the framework of the National Centre of Competence in Research (NCCR) PlanetS supported by the Swiss National Science Foundation. This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement SCORE No 851555). O.D.S.D. is supported in the form of work contract (DL 57/2016/CP1364/CT0004) funded by national funds through Fundação para a Ciência e a Tecnologia (FCT). M.E. acknowledges the support of the DFG priority programSPP 1992 “Exploring the Diversity of Extrasolar Planets” (HA 3279/12-1). A.O. is funded by an STFC studentship. J.K. gratefully acknowledge the support of the Swedish National Space Agency (SNSA; DNR 2020-00104). This work makes use of observations from the LCOGT network. This paper is based on observations made with the MuSCAT3 instrument, developed by the Astrobiology Center and under financial supports by ISPS KAKENHI (IP18H05439) and 1ST PRESTO (IPMIPR1775), at Faulkes Telescope North on Maui, HI, operated by the Las Cumbres Observatory. Some of the observations in the paper made use of the High-Resolution Imaging instrument Zorro obtained under Gemini LLP Proposal Number: GN/S-2021A-LP-105. Zorro was funded by the NASA Exoplanet Exploration Program and built at the NASA Ames Research Center by Steve B. Howell, Nie Scott, Elliott P. Horch, and Emmett Quigley. Zorro was mounted on the Gemini North (and/or South) telescope of the international Gemini Observatory, a program of NSF’s OIR Lab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. on behalf of the Gemini partnership: the National Science Foundation (United States), National Research Council (Canada), Agencia Nacional de Investigación y Desarrollo (Chile), Ministerio de Ciencia, Tecnología e Innovación (Argentina), Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brazil), and Korea Astronomy and Space Science Institute (Republic of Korea). We acknowledge the use of public TESS data from pipelines at the TESS Science Office and at the TESS Science Processing Operations Center. Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center for the production of the SPOC data products. The MEarth Team gratefully acknowledges funding from the David and Lucile Packard Fellowship for Science and Engineering (awarded to D.C.). This material is based upon work supported by the National Science Foundation under grants AST-0807690, AST-1109468, AST-1004488 (Alan T. Waterman Award), and AST-1616624, and upon work supported by the National Aeronautics and Space Administration under Grant No. 80NSSC18K0476 issued through the XRP Program. This work is made possible by a grant from the John Templeton Foundation. The opinions expressed in this publication are those of the authors and do not necessarily reflect the views of the John Templeton Foundation. This research made use of Astropy, (a community-developed core Python package for Astronomy, Astropy Collaboration 2013, 2018), SciPy (Virtanen et al. 2020), matplotlib (a Python library for publication quality graphics Hunter 2007), and numpy (Harris et al. 2020). This research has made use of NASA’s Astrophysics Data System Bibliographic Services. This research has made use of the SIMBAD database, operated at CDS, Strasbourg, France., With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).

Correction to: European Review for Medical and Pharmacological Sciences 2021; 25 (2): 770-778-DOI: 10.26355/eurrev_202101_24638-PMID: 33577031, published online 31 January 2021. After publication, the authors found some mistakes in the article. There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/24638.

Vertical position stability plays a crucial role in maintaining safe and reliable plasma operation for long-pulse fusion devices. In general, the vertical position is measured by using inductive magnetic coils installed inside the vacuum vessel; however, the integration drift effects are inherent for steady-state or long-pulse plasma operation. Developing a non-magnetic approach provides a fusion reactor-relevant steady-state solution that avoids the negative impact of integration drift. In this paper, we compare the non-inductively determined vertical position achieved by line-integrated interferometer and polarimeter measurements to that employing an inductive flux loop for a 1056 s discharge recently achieved on EAST (Experimental Advanced Superconducting Tokamak). Experimental results show that the non-inductive measurement is more robust than flux loops after 300 s if the integrator is not reset to suppress integrator drift. Real-time vertical position control using the non-inductive system is proposed for the next EAST experimental campaign.

主动脉瓣二瓣化畸形（BAV）是一种常见的先天性心脏病，其可能与遗传有关，目前已知基因包括NOTCH1、ROBO4、SMAD6、FBN1、ACTA2等。该文报道1例主动脉瓣二瓣化畸形合并肺动脉高压及室性期前收缩患儿，术前有急性心功能不全，行主动脉瓣成形术，术后出现严重低心排综合征，体外膜肺氧合（ECMO）及肾替代治疗（CRRT）后，心功能无明显改善，最终死亡。全外显子测序和基因组低深度测序发现患儿携带SMAD6基因两处杂合变异（c.165delC和c.248GA），经家系验证均为新发变异，同时患者核型为45， X，为Turner综合征。.

The clinical data of 18 patients with biopsy-proven IgG4-related kidney disease (IgG4-RKD) in Peking University First Hospital from Jananuary 2012 to Jananuary 2017 were analyzed retrospectively. The prevalence of elevated IgG4 and hypocomplement C3 were commonly found. Acute kidney disease accounted for 9 cases. Pathological examination showed IgG4 associated tubulointerstitial nephritis, with IgG4-ANCA or anti-PLA2R associated crescentic nephritis in 3 cases, and membranous nephropathy in 2 cases. Patients with erythrocyte sedimentation rate60 mm/1 h had higher acute tubulointerstitial injury scores. Improved renal function was observed in 15 patients under immunosuppressive therapy. But 3 patients relapsed during follow-up. IgG4-RKD with concurrent glomerulopathy is not uncommon. Biopsy-based kidney examination is recommended.回顾性分析2012年1月至2017年1月北京大学第一医院18例经肾病理确诊为IgG4相关性肾病（IgG4-RKD）患者的特点和预后。患者血IgG4升高和低补体C3血症常见，其中9例符合急性肾病诊断，IgG4相关肾小管间质炎伴新月体肾炎3例，伴膜性肾病共2例。红细胞沉降率60 mm/1 h的患者，肾小管间质急性损伤评分较高；免疫抑制治疗可使患者肾功能改善，其中3例复发。可见IgG4-RKD合并肾小球病不少见，应及时行肾病理评估。.

Our study aims to evaluate the endothelial cell-podocyte crosstalk in proliferative lupus nephritis (LN). The semi-quantification scores of glomerular endothelial cell injury and the foot process width (FPW) were processed in 110 proliferative LN patients. Podocytes were stimulated with LN-derived IgG. Glomerular endothelial cells were treated with podocyte-conditioned medium (PCM), and then podocytes were incubated with endothelial cell–conditioned medium (ECM). The levels of vascular endothelial growth factor-A (VEGF-A) in PCM and endothelin-1 in ECM were analyzed, and the injury of podocyte and glomerular endothelial cells were further evaluated. The pathological score of glomerular endothelial cell injury was correlated with FPW in LN complicated with thrombotic microangiopathy. In vitro study showed the following: 1. Stimulation of podocytes by IgG from LN led to decline in the expression of nephrin with cytoskeleton rearrangement, and reduction of VEGF-A levels. 2. Exposure of glomerular endothelial cells to PCM incubated with LN-derived IgG (PCM-LN) induced more endothelin-1 secretion and disruption of intercellular tight junction. 3. Exposure of podocytes to ECM stimulated with PCM-LN could induce cytoskeleton redistribution with decrease of nephrin. In conclusion, the pathological glomerular endothelial cell lesions were associated with FPW and the VEGF-endothelin-1 system might play a critical role in the endothelial cell-podocyte crosstalk in LN.

Human leukocyte antigen (HLA)-E is a nonclassical HLA molecule with limited polymorphisms. Genotype frequency and expression of HLA-E were examined here for the first time in acute leukemia patients and healthy controls. The frequency of HLA-E*01:03/*01:03 individuals was significantly higher (p = .008, OR = 1.845), while the frequency of HLA-E*01:01/*01:01 individuals was much lower in the patient group (p = .002, OR = .363) than in control group. The surface expression on HLA-E*01:03/*01:03 individuals was found to be significantly higher than on HLA-E*01:01/*01:01 individuals in both of acute leukemia and control groups, but no significant difference was observed between the corresponding genotypes in two groups. However, the level of expression of soluble HLA-E is significantly higher in patients than in the control group, but there was no genotype-specific expression in either group. These findings indicate that soluble HLA-E secretion and HLA-E*01:03/*01:03 genotype that brings higher surface expression might play important roles in the mechanisms underlying tumor escape in acute leukemia.

Purpose The aim of this study was to design and fabricate a three-dimensional (3D) printed artificial ovary. Methods We first compared the printability of gelatin-methacryloyl (GelMA), alginate and GelMA-alginate bioinks, of which GelMA was selected for further investigation. The swelling properties, degradation kinetics and shape fidelity of GelMA scaffolds were characterized by equilibrium swelling/lyophilization, collagenase processing and micro-computed tomography evaluation. Commercial ovarian tumor cell lines (COV434, KGN, ID8) and primary culture ovarian somatic cells were utilized to perform cell-laden 3D printing, and the results were evaluated by live/dead assays and TUNEL detection. Murine ovarian follicles were seeded in the ovarian scaffold and their diameters were recorded every day. Finally, in vitro maturation was performed, and the ovulated oocytes were collected and observed. Results Our results indicated that GelMA was suitable for 3D printing fabrication. Its scaffolds performed well in terms of hygroscopicity, degradation kinetics and shape fidelity. The viability of ovarian somatic cells was lower than that of commercial cell lines, suggesting that extrusion-based 3D culture fabrication is not suitable for primary ovarian cells. Nevertheless, the GelMA-based 3D printing system provided an appropriate microenvironment for ovarian follicles, which successfully grew and ovulated in the scaffolds. Metaphase II oocytes were also observed after in vitro maturation. Conclusions The GelMA-based 3D printing culture system is a viable alternative option for follicular growth, development and transfer. Accordingly, it shows promise for clinical application in the treatment of female endocrine and reproductive conditions.

China is a country with high incidence of esophageal cancer. Advanced esophageal cancer not only brings serious threat to the health of patients, but also brings heavy economic burden to their families and society. Early diagnosis and treatment of esophageal cancer are always the hot spot in clinical research, and gastroscopy screening is the key point. The development of artificial intelligence is expected to provide new mean for early diagnosis and treatment of esophageal cancer in the aspects of endoscopy procedure and quality control.Through a brief overview of the concept and development of artificial intelligence in endoscopic diagnosis of superficial esophageal cancer, this study summarizes and reviews the research progress of artificial intelligence in the diagnosis of superficial esophageal carcinoma, and illustrates the importance of its application. This study also discusses the main problems and difficulties of artificial intelligence in the endoscopic diagnosis of esophageal carcinoma. It prospects the application of artificial intelligence in endoscopic esophageal diagnosis in the future.中国是食管癌高发国家，中晚期食管癌不仅给患者生命健康带来严重威胁，也给其家庭和社会带来沉重的经济负担。食管癌的早诊早治一直是临床医学研究的热点，而胃镜筛查是食管癌早诊早治的关键，人工智能的发展有望在内镜检查和质控等方面为食管癌早诊早治提供新的辅助手段。文章通过概述人工智能在早期食管癌内镜诊断中的应用和发展，归纳了人工智能在早期食管癌诊断中的研究结果，阐明其应用的重要性，总结了人工智能在早期食管癌内镜诊断中的难点及问题，并对未来人工智能在食管癌内镜诊断中的应用进行展望。.

Nasopharyngeal carcinoma (NPC) is the commonest malignant tumor. In this article, we aimed to examine the molecular role of lncRNA HEIH in the progression of NPC.We assessed the expression of HEIH, miR-193a-5p and CDK8 in NPC tissues and cells by real-time PCR. The cell proliferation, invasion and migration of SUNE-1 cells were examined by CCK-8 and transwell assay. Western blot assay was adopted to measure the protein expression level of CDK8. Dual-Luciferase reporter assay was adopted to evaluate the correlation between HEIH, miR-193a-5p and CDK8.We discovered that HEIH was high expressed and miR-193a-5p was reduced in both NPC tissues and cells. The upregulation of HEIH facilitated cell proliferation, migration and invasion of SUNE-1 cells. In addition, overexpression of miR-193a-5p restrained cell progression of SUNE-1 cells. Moreover, HEIH was proved to be a molecular sponge of miR-193a-5p in NPC. Besides that, CDK8 was found to be a direct target gene of miR-193a-5p in NPC. Furthermore, CDK8 knockdown suppressed cell progression of SUNE-1 cells.Our data demonstrated that HEIH overexpression promoted cell progression by sponging miR-193a-5p and upregulating CDK8.

Chronic kidney disease (CKD) and hypertension are two closely interlinked public health problems. Kidney is an important organ for regulating blood pressure. Renal lesions may lead to increased blood pressure, and hypertension further accelerates the progression of renal disease, thereby forming a vicious circle which affects the prognosis of patients. Volume overload is an important mechanism in the development of hypertension in patients with CKD. Therefore, more emphasis should be put on volume management of CKD patients with hypertension.慢性肾脏病和高血压是两个密切相关的公共健康问题。肾脏是调节血压的重要器官，肾脏病变可以导致血压升高，高血压又进一步加快肾脏病变进展，形成恶性循环，影响患者预后。容量扩张是慢性肾脏病患者高血压发生的重要机制。因此，应注重慢性肾脏病高血压患者的容量管理。.

分析一个以心肌病为主要表现的中国人线粒体肌病家系的临床、病理及致病基因特点。该家系4代共有患者8例，先证者以双下肢水肿为首发表现，伴有胸闷、气喘及运动后肌肉酸痛无力，其余患者表现为运动耐力下降或运动后肌肉酸痛无力，其中2例伴胸闷、气喘；所有患者体形消瘦、精神运动发育正常。先证者头颅MRI正常，肌电图提示神经源性改变，肌肉病理可见破碎红纤维及坏死、再生和核内移肌纤维；全外显子测序未见与疾病相关的基因突变，线粒体基因2代测序发现先证者A3243G突变，1代测序证实该突变与家系内患者共分离。单纯线粒体肌病患者可以心肌病为主要表现，肌电图可呈神经源性改变；对不明原因的以心肌受累为主要表现的患者应考虑线粒体肌病可能，尽早行肌肉病理和基因检查明确诊断。.

In this retrospective cohort study, we aim to evaluate the effect of endocapillary hypercellularity (E) lesions on the renal prognosis and response to immunosuppressive therapy, especially diffuse endocapillary hypercellularity lesion in IgA nephropathy (IgAN). A total of 365 patients with IgAN and E lesions and 31 patients with diffuse E lesions and over 12-month follow-up period were included in this study. We performed an 1∶1 propensity score to identify controls with matched clinical and pathological features from 769 IgAN patients without E lesions. The end-point was defined as a 30% decrease in estimated glomerular filtration rate (eGFR) or end-stage kidney disease. The kidney survival of the two groups was compared by Kaplan-Meier analysis. During median follow-up period of 41 months, kidney survival rates in patients with E lesions were 96.0% at 1 year, 83.6% at 3 years, 67.7% at 5 years; while they were 96.9% at 1 year, 83.6% at 3 years, and 68.7% at 5 years in patients without E lesions (探索毛细血管内细胞增多（E）病变尤其是弥漫性E病变在IgA肾病临床进展及治疗中的意义。选随访时间超过12个月的IgA肾病合并E病变者365例，其中IgA肾病合并弥漫性E病变者31例；通过倾向性匹配方法，按1∶1比例选基线数据与研究人群相匹配的IgA肾病未合并E病变者769例。以基线估算肾小球滤过率（eGFR）下降30%、终末期肾病为混合研究终点。分析患者的肾脏生存情况。结果显示，（1）中位随访41个月， Kaplan-Meier分析显示，合并E病变IgA肾病者（130例）肾脏生存率1年为96.0%，3年为83.6%，5年为67.7%；未合并E病变IgA肾病者（131例）肾脏生存率1年为96.9%，3年为83.6%，5年为68.7%；两者比较差异无统计学意义（