1. Inheritance of β-mannosidosis in goats
- Author
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Cavanagh K, R. A. Fisher, E. J. S. Rathke, J. A. Kelley, Dunstan Rw, and Margaret Z. Jones
- Subjects
β mannosidosis ,Genetics ,Genotype ,Genetic Carrier Screening ,Goats ,beta-Mannosidase ,Inheritance (genetic algorithm) ,General Medicine ,Plasma levels ,Biology ,medicine.disease ,Pedigree ,Mannosidosis ,Phenotype ,Mannosidases ,alpha-Mannosidosis ,Lysosomal storage disease ,medicine ,Carrier status ,Animals ,Animal Science and Zoology ,Mating - Abstract
Plasma levels of beta-mannosidase activity were measured in the phenotypically normal members of a family of goats in which 12 cases of beta-mannosidosis have been reported. Normal or carrier genotypes were assigned on the basis of these results, and mating tables drawn up. Similar data were collected on a number of other small families unrelated to the one with beta-mannosidosis. The results indicate that the plasma beta-mannosidase level is a reasonably good indicator of carrier status and confirm that the disease beta-mannosidosis is inherited in a recessive manner and is not X-linked.
- Published
- 2009