566 results on '"S Paz"'
Search Results
2. Imidazole-based optical sensors as a platform for bisulfite sensing and BSA/HSA interaction study. An experimental and theoretical investigation
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R. S. Paz, Esther, Isoppo, Victoria G., dos Santos, Fabíola S., Machado, Luana A., de Freitas, Rossimiriam P., Silva Junior, Henrique C., Chaves, Otávio A., Iglesias, Bernardo A., Rodembusch, Fabiano S., and da Silva Júnior, Eufrânio N.
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- 2023
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3. Nitrate removal in saline water by photo-reduction using natural FeTiO3 as catalyst
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Jefferson E. Silveira, Alicia L. Garcia-Costa, Jaime Carbajo, Alyson R. Ribeiro, Gema Pliego, Wendel S. Paz, Juan A. Zazo, and Jose A. Casas
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Nitrate ,Photo-reduction ,Brackish groundwater ,Ilmenite ,Water conditioning ,Chemical engineering ,TP155-156 - Abstract
As climate change progresses, there is an increasing interest on the use of non-conventional water sources such as brackish or saline waters. Nowadays, the main threat in Europe detected in these waterbodies is nitrate contamination. Within the multiple available methods studied for nitrate reduction, photocatalysis presents promising results, but this technology has not yet been tested in saline water. This work tackles the elimination of nitrate ([NO3−] =50 mg/L) in brackish and saline water ([sea salt] = 5–33 g/L) using ilmenite as photocatalyst and oxalic acid as an environmental-friendly reducing agent. The main challenge when working in saline water is to overcome oxalic acid scavenging by Ca2+ present in the water matrix. This can be solved either working at over stoichiometric concentrations of oxalic acid (≈300% stoich. dose) or acidifying the reaction media. The addition of hydrochloric acid ensures the protonation of oxalic acid, reducing drastically its precipitation as CaC2O4. Working at [C2O42−] = 180 mg/L, [FeTiO3] = 450 mg/L and [HCl 37%] = 13 mM, 73% total nitrogen (TN) elimination was reached after 420 min. Reaction temperature was also evaluated in the range of 20–80 °C, which allowed to calculate the Ea=9.8 kJ/mol. Finally, the effect of dissolved O2 on the TN reduction was assessed. Overall, photocatalytic nitrate reduction presents itself as a feasible technology regardless of the water salinity.
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- 2022
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4. A meta-review of literature reviews assessing the capacity of patients with severe mental disorders to make decisions about their healthcare
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A. Calcedo-Barba, A. Fructuoso, J. Martinez-Raga, S. Paz, M. Sánchez de Carmona, and E. Vicens
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Decision making capacity ,Mental disorder ,Schizophrenia ,Bipolar disorder ,Literature review ,Meta-review ,Psychiatry ,RC435-571 - Abstract
Abstract Background Determining the mental capacity of psychiatric patients for making healthcare related decisions is crucial in clinical practice. This meta-review of review articles comprehensively examines the current evidence on the capacity of patients with a mental illness to make medical care decisions. Methods Systematic review of review articles following PRISMA recommendations. PubMed, Scopus, CINAHL and PsycInfo were electronically searched up to 31 January 2020. Free text searches and medical subject headings were combined to identify literature reviews and meta-analyses published in English, and summarising studies on the capacity of patients with serious mental illnesses to make healthcare and treatment related decisions, conducted in any clinical setting and with a quantitative synthesis of results. Publications were selected as per inclusion and exclusion criteria. The AMSTAR II tool was used to assess the quality of reviews. Results Eleven publications were reviewed. Variability on methods across studies makes it difficult to precisely estimate the prevalence of decision-making capacity in patients with mental disorders. Nonetheless, up to three-quarters of psychiatric patients, including individuals with serious illnesses such as schizophrenia or bipolar disorder may have capacity to make medical decisions in the context of their illness. Most evidence comes from studies conducted in the hospital setting; much less information exists on the healthcare decision making capacity of mental disorder patients while in the community. Stable psychiatric and non-psychiatric patients may have a similar capacity to make healthcare related decisions. Patients with a mental illness have capacity to judge risk-reward situations and to adequately decide about the important treatment outcomes. Different symptoms may impair different domains of the decisional capacity of psychotic patients. Decisional capacity impairments in psychotic patients are temporal, identifiable, and responsive to interventions directed towards simplifying information, encouraging training and shared decision making. The publications complied satisfactorily with the AMSTAR II critical domains. Conclusions Whilst impairments in decision-making capacity may exist, most patients with a severe mental disorder, such as schizophrenia or bipolar disorder are able to make rational decisions about their healthcare. Best practice strategies should incorporate interventions to help mentally ill patients grow into the voluntary and safe use of medications.
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- 2020
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5. The China Shock Impact on Labor Informality: The Effects on Brazilian Manufacturing Workers
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Lourenço S. Paz
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Brazil ,China ,import penetration ,informal labor markets ,wages ,Economics as a science ,HB71-74 - Abstract
The vigorous growth of the Chinese economy together with its increasingly successful role in international trade may have profoundly impacted developing countries. This study examines the large increase in the international trade exposure of the Brazilian economy during 2000–2012 to assess the impacts of import competition on its manufacturing formal and informal labor markets. In this period, import penetration grew by more than 20 percent in Brazil, and the share of the import penetration originating in China increased from 3 to 20 percent. At the same time, the share of informal workers in manufacturing declined from 27 to approximately 15 percent. Employing a switching regression model and Brazilian household survey data, this study finds that a greater industry-level Chinese and ‘rest of the world’ import penetration increases the likelihood of jobs becoming informal at different intensities, and these effects are smaller in unskilled-labor intensive industries and manufacturing states. Additionally, both types of import penetration positively impact the average informal wage. In contrast, the estimates suggest that a larger Chinese import penetration reduces average formal wages, while imports from elsewhere have the opposite effect. The results also indicate that the magnitude of the effects on wages are moderated by the unskilled labor intensity of the industry and whether the worker is located in a manufacturing state.
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- 2022
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6. Adoption Preference on Stray Animals: Basis for Animal Welfare Campaign
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Sally Daniels C. Balones, Ruth Danielle M. Andres, John Mark B. Ceremonia, Zhidney Nahla C. Espiritu, Niño Judiel S. Paz, Jireh Elijah R. Rodriguez, Jose Mari Emmanuel D. Vendil, Jed Capistrano, and Thania S. Maribojoc
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animal welfare campaign ,stray animals ,preference ,adoption - Abstract
This study aims to focus on the preferences of the community regarding the adoption of stray animals in Morong, Rizal. The data collection was conducted with five (5) pet owners in each of the 8 barangays in Morong, Rizal, in 2023. Based on the findings of this study, the researchers found that the pet owner-respondents in Morong, Rizal, are most likely ready to adopt stray animals based on their preferences in terms of type, breed, condition, and color. Their reasons correspond to the subjective theory of value since they talk about how valuable the animal’s life is to them. The pet owners of Morong, Rizal who are ready to adopt mostly prefer dogs and cats, due to that they prefer types that are beneficial to the owners with good physical state and behavior (type), askal/Aspin as their most preferred breed, due to that their most preferred breeds are any breeds and breeds don’t matter to the pet owners/respondents (breed), healthy, as they want animals that ensure better living and a long lifespan (condition), mostly prefer brown color, and have color that is interesting, lovely, and color they like (color). When adopting stray animals, the respondents' choice of preferences is subjective in two (2) ways. These are what seem the basis of individuals when selecting a pet to please their satisfaction on their different judgments. The researchers will propose an advocacy campaign promoting the adoption of stray animals, specifically encouraging the attributes that are not mostly preferred in strays. The key themes from the thematic analyses of the different preferences showed that although they valued animals’ lives regardless of their kind, some tended to select them due to their appearance and benefits.
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- 2023
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7. Aryl-Phenanthro[9,10-d]imidazole: A Versatile Scaffold for the Design of Optical-Based Sensors
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Gleiston G. Dias, Marieli O. Rodrigues, Esther R. S. Paz, Mateus P. Nunes, Maria H. Araujo, Fabiano S. Rodembusch, and Eufrânio N. da Silva Júnior
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Fluid Flow and Transfer Processes ,Process Chemistry and Technology ,Bioengineering ,Instrumentation - Published
- 2022
8. The influence of international trade on labour productivity in services: The case of Brazil in the 1990s
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H. Stephen Gardner, Lourenço S. Paz, and John Ssozi
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Geography, Planning and Development ,Development - Published
- 2022
9. Enseñar a leer y escribir en educación inicial
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María Cristina Solís Zañartu, Emy Suzuki S., Paz Baeza B. and María Cristina Solís Zañartu, Emy Suzuki S., Paz Baeza B.
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- 2018
10. New Evidence on WTO Membership After the Uruguay Round: An Analysis at the Sectoral Level
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Lourenço S. Paz, Magnus dos Reis, and André Filipe Zago de Azevedo
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Economics and Econometrics - Published
- 2023
11. Efzofitimod, a Novel Immunomodulator for Pulmonary Sarcoidosis, Modulates Patient Inflammatory Responses Through Myeloid Cells
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D. Siefker, S. Paz, S. Tyler, M. Ferrer, E. Escobedo, Y.E. Chong, L. Zhai, Z. Xu, L. Guy, K. Rauch, S. Klopp-Savino, K.S. Hamel, L. Burman, G. Walker, and L.N. Nangle
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- 2023
12. Development of a formulation with retinoic acid for stretch marks and its primary stability
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F. G. S. Paz, L. F. Amorim, S. F. S. Moraes, P. G. Sampaio, S. A. Marques, and A. E. Bighetti
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stretch. retinoic acid. stability ,General Works - Abstract
Stretch marks are undesirable skin changes, defined as visible linear scars that are arranged parallel to each other and may be rare or numerous and indicate an injury to the skin because there is an elastic localized imbalance. There is evidence that their appearance is multifactorial, not only mechanical and endocrine factors, but genetic and familial predisposition. The highest incidence occurs among females, aged 12 and 14, and children 12 to 15 years. The objective of this study was to develop a formulation containing the Retinoic Acid in the concentration of 2%, based on preliminary studies of stability, so that proves a better effectiveness of this asset in restoring the appearance of striated skin, seeking to improve the physical appearance and psychological people affected by stretch. As part of the study we developed we used the tests of physical and chemical stability, such as organoleptic characteristics, pH, viscosity, thermal stress, and centrifugation cycle freezes and thaws. The applied tests show that retinoic acid behaves within the standards required for the formulation development.
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- 2017
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13. Open flap debridement compared to repeated applications of photodynamic therapy in the treatment of residual pockets: A randomized clinical trial
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Naira M. R. B. Andere, Nídia C. Castro dos Santos, Cássia F. Araújo, Hélvis E. S. Paz, Luciana M. Shaddox, Renato C. V. Casarin, and Mauro P. Santamaria
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Photosensitizing Agents ,Periodontal Debridement ,Treatment Outcome ,Photochemotherapy ,Debridement ,General Engineering ,Humans ,Periodontics ,Gingival Recession ,Combined Modality Therapy - Abstract
The aim of the present study was to compare repeated applications of antimicrobial photodynamic therapy (aPDT) to open flap debridement (OFD) in the treatment of residual periodontal pockets in non-furcation sites.Forty-six subjects with a diagnosis of Stage III or IV Grade C periodontitis, that had been previously treated, participated in the study. Residual pockets were divided between two groups: (1) aPDT group: received ultrasonic periodontal debridement followed by immediate application of aPDT, and repeated on1st, 2nd, 7th, and 14th days; and (2) OFD group: treated by modified papilla preservation technique, where granulation tissue and visible calculus were removed with hand curettes and an ultrasonic device. Clinical, immunological, and microbiological parameters were evaluated before and after treatment.Both treatments were effective reducing clinical parameters of disease. OFD resulted in a greater mean probing pocket depths (PPD) reduction in deep pockets (p = 0.001). However, aPDT resulted in a lower occurrence of gingival recession (GR), dentin hypersensitivity (DH) and analgesic intake. Reduction in Porphyromonas gingivalis was observed in both groups. Only the OFD group had a significant reduction in Aggregatibacter actinomycetemcomitans. aPDT group had greater increase in interleukin 10 (IL-10) levels and a greater reduction of interleukin 1 beta (IL-1β) at 14 days when compared to the OFD group (p 0.05).OFD was superior in reducing PPD in deep pockets compared to the aPDT. However, OFD resulted in greater GR. Both treatments lowered P. gingivalis levels but only OFD reduced levels of A. actinomycemtemcomitans.
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- 2022
14. Salivary annexin <scp>A1</scp> : A candidate biomarker for periodontitis
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Renato C. V. Casarin, Cristiane R. Salmon, Camila S. Stolf, Hélvis E. S. Paz, Thiago P. Rangel, Romênia R. Domingues, Bianca A. Pauletti, Adriana F. Paes‐Leme, Cassia Araújo, Mauro P. Santamaria, Karina S. Ruiz, and Mabelle F. Monteiro
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Periodontics - Published
- 2023
15. Peripheral eosinophil trends and clinical outcomes after non-traumatic subarachnoid hemorrhage
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Hugo Gonzalez Gomez, Jude P. J. Savarraj, Atzhiry S. Paz, Xuefang Ren, Hua Chen, Louise D. McCullough, Huimahn A. Choi, and Aaron M. Gusdon
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Neurology ,Neurology (clinical) - Abstract
Background/objectiveUncontrolled systemic inflammation after non-traumatic subarachnoid hemorrhage (SAH) is associated with worse outcomes. Changes in the peripheral eosinophil count have been linked to worse clinical outcomes after ischemic stroke, intracerebral hemorrhage, and traumatic brain injury. We aimed to investigate the association of eosinophil counts with clinical outcomes after SAH.MethodsThis retrospective observational study included patients with SAH admitted from January 2009 to July 2016. Variables included demographics, modified Fisher scale (mFS), Hunt–Hess Scale (HHS), global cerebral edema (GCE), and the presence of any infection. Peripheral eosinophil counts were examined as part of routine clinical care on admission and daily for 10 days after aneurysmal rupture. Outcome measures included dichotomized discharge mortality, modified Ranked Scale (mRS) score, delayed cerebral ischemia (DCI), vasospasm, and need for ventriculoperitoneal shunt (VPS). Statistical tests included the chi-square test, Student's t-test, and multivariable logistic regression (MLR) model.ResultsA total of 451 patients were included. The median age was 54 (IQR 45, 63) years, and 295 (65.4%) were female patients. On admission, 95 patients (21.1%) had a high HHS (>4), and 54 (12.0%) had GCE. A total of 110 (24.4%) patients had angiographic vasospasm, 88 (19.5%) developed DCI, 126 (27.9%) had an infection during hospitalization, and 56 (12.4%) required VPS. Eosinophil counts increased and peaked on days 8–10. Higher eosinophil counts on days 3–5 and day 8 were seen in patients with GCE (p < 0.05). Higher eosinophil counts on days 7–9 (p < 0.05) occurred in patients with poor discharge functional outcomes. In multivariable logistic regression models, higher day 8 eosinophil count was independently associated with worse discharge mRS (OR 6.72 [95% CI 1.27, 40.4], p = 0.03).ConclusionThis study demonstrated that a delayed increase in eosinophils after SAH occurs and may contribute to functional outcomes. The mechanism of this effect and the relationship with SAH pathophysiology merit further investigation.
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- 2023
16. PERFIL EPIDEMIOLÓGICO DOS CATADORES DE RESÍDUOS SÓLIDOS PORTADORES DE HIPERTENSÃO E DIABETES, DF-BRASIL
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A. S. MENEZES, P. M. F. ESCALDA, V. R. N. CRUVINEL, and L. P. S. PAZ
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- 2023
17. Spin State Engineering of Triangulene Graphene Embedded in H-Bn Nanoflake
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L. Fiorini Filho, C. J. Terroso, F. A. L. de Souza, W. S. Paz, and Fernando Nespoli Nassar Pansini
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- 2023
18. Stability of plane-parallel flow of magnetic fluids under external magnetic fields
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P. Z. S. Paz, F. R. Cunha, and Y. D. Sobral
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Mechanics of Materials ,Applied Mathematics ,Mechanical Engineering - Published
- 2022
19. Cathepsin L and acute ischemic stroke: A mini-review
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Linda Ma, Silin Wu, Aaron M. Gusdon, Hua Chen, Heng Hu, Atzhiry S. Paz, Jaroslaw Aronowski, Jude P. Savarraj, Ryan S. Kitagawa, Huimahn A. Choi, and Xuefang S. Ren
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Ischemic stroke is a serious cerebrovascular event that results in cell death, blood-brain barrier dysfunction, tissue degradation, and inflammation, often leading to permanent disability or death. As the incidence of ischemic stroke continues to rise globally, it is crucial to examine the mechanisms of the various proteins and molecules contributing to worsened patient outcome and recovery. Cathepsin L, a cysteine protease known for degrading tissues in lysosomes and elsewhere, may play a role in brain tissue loss and inflammation after stroke. Studies have suggested that cathepsin L appears in the ischemic core shortly after stroke is induced. Using immunohistochemical staining, mass spectrometry, and other assays, the increase of cathepsin L in the brain was correlated with extracellular matrix and perlecan degradation after ischemic stroke. Additionally, injection of a cathepsin L inhibitor significantly reduced brain infarct size and improved functional scores. More research is needed to elucidate cathepsin L's role in post-stroke inflammation and brain damage, in order to further explore the factors contributing to worsened patient outcome after ischemic stroke and work toward finding better therapeutic interventions.
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- 2022
20. Aryl-Phenanthro[9,10
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Gleiston G, Dias, Marieli, O Rodrigues, Esther R S, Paz, Mateus, P Nunes, Maria H, Araujo, Fabiano S, Rodembusch, and Eufrânio N, da Silva Júnior
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Imidazoles ,Water ,Colorimetry ,Protons - Abstract
Fluorescent and colorimetric sensors are important tools for investigating the chemical compositions of different matrices, including foods, environmental samples, and water. The high sensitivity, low interference, and low detection limits of these sensors have inspired scientists to investigate this class of sensing molecules for ion and molecule detection. Several examples of fluorescent and colorimetric sensors have been described in the literature; this Review focuses particularly on phenanthro[9,10
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- 2022
21. Franckeite as an Exfoliable Naturally Occurring Topological Insulator
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Wendel S. Paz, Rodrigo B. Capaz, Juan Jose Palacios, Matěj Velický, Maria Varela, G. Sanchez-Santolino, Nathanael N. Batista, and Marcos G. Menezes
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Quantum phase transition ,Phase transition ,Materials science ,Condensed matter physics ,business.industry ,Mechanical Engineering ,Superlattice ,Bioengineering ,Heterojunction ,General Chemistry ,Crystal structure ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,Condensed Matter Physics ,Phase Transition ,Condensed Matter::Materials Science ,Semiconductor ,Microscopy, Electron, Transmission ,Semiconductors ,Topological insulator ,General Materials Science ,Density functional theory ,business - Abstract
Franckeite is a natural superlattice composed of two alternating layers of different composition which has shown potential for optoelectronic applications. In part, the interest in franckeite lies in its layered nature which makes it easy to exfoliate into very thin heterostructures. Not surprisingly, its chemical composition and lattice structure are so complex that franckeite has escaped screening protocols and high-throughput searches of materials with nontrivial topological properties. On the basis of density functional theory calculations, we predict a quantum phase transition originating from stoichiometric changes in one of franckeite composing layers (the quasihexagonal one). While for a large concentration of Sb, franckeite is a sequence of type-II semiconductor heterojunctions, for a large concentration of Sn, these turn into type-III, much alike InAs/GaSb artificial heterojunctions, and franckeite becomes a strong topological insulator. Transmission electron microscopy observations confirm that such a phase transition may actually occur in nature.
- Published
- 2021
22. Emergence of Topological Edge States in Oxidized α-In2Se3 Nanosheets: Implications for Field-Effect Transistors
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Erik F. Procopio, Juan Jose Palacios, Nathanael N. Batista, Wendel S. Paz, Wanderlã L. Scopel, and Fábio A. L. de Souza
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Materials science ,Condensed matter physics ,General Materials Science ,Field-effect transistor ,Edge states - Published
- 2021
23. Estímulos auditivos en prácticas de neuromarketing. Caso: Centro Comercial Unicentro, Cúcuta, Colombia
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William R. Avendaño Castro, Luisa S. Paz Montes, and Gerson Rueda Vera
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emociones ,estímulo sonoro ,marketing auditivo ,marketing sensorial ,neuromarketing ,Business ,HF5001-6182 - Abstract
El actual entorno competitivo de mercados involucra la aplicación estratégica del neuromarketing como ayuda al aumento del consumismo y prevalencia de marcas y productos. La estimulación sensorial se usa como técnica valiosa en el contexto empresarial, es decir marketing sensorial. Esta investigación propone realizar una evaluación de las prácticas de marketing auditivo a través de los estímulos sonoros en 52 establecimientos comerciales del Centro Comercial Unicentro, uno de los más destacados en la ciudad de Cúcuta, Norte de Santander, Colombia. El tamaño muestral comprende 30 establecimientos dedicados a textiles, 15 a comidas, 2 a diversión, 2 a libros y 3 a tecnología. Se recopiló la información mediante la aplicación de una matriz de captación sensorial auditiva destacando las características sonoras del centro comercial y de los establecimientos, además reacciones de los visitantes por estímulos sonoros y su ubicación. Los resultados evidencian el uso inadecuado de marketing auditivo por parte de un número representativo de establecimientos y la ausencia del mismo en otros, lo que refleja la necesidad de implementar estrategias auditivas eficaces que permitan la atracción de clientes y por lo tanto, la inducción de compra a través de su permanencia en los espacios comerciales
- Published
- 2015
24. A novel neuropilin-2 (NRP2) antibody for immunohistochemical staining of patient tissue samples
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Y Chong, S Förster, D Siefker, Y Becker, E Escobedo, L Burman, K Rauch, S Paz, C Burkart, A Cubitt, M Muders, and L Nangle
- Published
- 2022
25. Immune response characterization of primary gingival fibroblasts from Grade C periodontitis patients
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Camila S. Stolf, Catharina M. Sacramento, Carolina A. P. G. Alvarenga, Jonathan R. Vieira, Cássia F. Araújo, Mabelle F. Monteiro, Hélvis E. S. Paz, Mauro P. Santamaria, Karina G. S. Ruiz, and Renato C. V. Casarin
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General Engineering ,Periodontics - Abstract
Grade C, Stage 3-4 Periodontitis (Perio4C) is a rapidly destructive disease caused by an unequilibrated immune response that starts after the primary contact of the periodontopathogens with the gingival tissue. However, it is still unclear how this imbalanced response initiates and what is the role of the connective tissue cells in the progression of this disease. Thus, this study aims to assess the local immune response of Perio4C patients through the exposure of primary gingival fibroblast cells (GFs) with Aggregatibacter actinomycetemcomitans protein extract (AaPE) and the quantification of the inflammatory cytokines interleukin (IL)-4, IL-17, tumor necrosis factor (TNF)-α, IL-1β, interferon (IFN)-γ, and IL-10 super-family members (IL-10, IL-19, and IL-24) secreted by them.Gingival biopsies from nine periodontally health (PH) and eight Perio4C patients were harvested, and the primary culture of GFs was obtained. The cells were exposed to AaPE (5 and 20 μg/ml) and 12-myristate 13-phorbol acetate and ionomycin - calcium salt (PMA). The supernatant was collected after 1.5 and 3 h, and a cytokine panel was evaluated.Clustering analysis indicated dissimilar and stimuli-dependent cytokine production between Perio4C and PH subjects. Perio4C GFs presented lower production of IL-4, TNF-α, IFN-γ, IL-17, IL-10, IL-24, and IL-19, while IL-1β levels were similar to the PH group, leading to a disruption in the pro-/anti-inflammatory cytokine ratio (p 0.05). IL-1β and IL-10 super-family were the most discriminative representants for PH and Perio4C, respectively.GFs from individuals with Perio4C tended to hypo-respond to stimulation with AaPE, producing lower concentrations of some pro- and anti-inflammatory molecules, trending to develop a pro-inflammatory extracellular environment.
- Published
- 2022
26. Ruthenium(II)-Catalyzed C–H/N–H Alkyne Annulation of Nonsymmetric Imidazoles: Mechanistic Insights by Computation and Photophysical Properties
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Luana A. Machado, Esther R. S. Paz, Maria H. Araujo, Leandro D. Almeida, Ícaro A. O. Bozzi, Gleiston G. Dias, Cynthia L. M. Pereira, Leandro F. Pedrosa, Felipe Fantuzzi, Felipe T. Martins, Luiz A. Cury, and Eufrânio N. da Silva Júnior
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Organic Chemistry ,Physical and Theoretical Chemistry - Abstract
Imidazoles constitute an important class of heterocyclic compounds with extensive potential use, from pharmaceuticals to optoelectronics. However, synthetic methodologies capable of producing novel nonsymmetric imidazoles are still scarce. In a combined synthesis, photophysical and computational investigation, we show that ruthenium(II) catalysis enables C−H/N−H alkyne annulation of nonsymmetric imidazoles derived from naturally occuring β-lapachone and nor-β-lapachone. This method provides an efficient and versatile tool for synthesizing fluorescent compounds with a broad application range.
- Published
- 2022
27. UHMK1 is a novel splicing regulatory kinase
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Vanessa C. Arfelli, Yun-Chien Chang, Johannes W. Bagnoli, Paul Kerbs, Felipe E. Ciamponi, Laissa M. da S. Paz, Serhii Pankivskyi, Jean de Matha Salone, Alexandre Maucuer, Katlin B. Massirer, Wolfgang Enard, Bernhard Kuster, Philipp A. Greif, and Leticia Fröhlich Archangelo
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Cell Biology ,Molecular Biology ,Biochemistry - Published
- 2023
28. Imidazoles and Oxazoles from Lapachones and Phenanthrene‐9,10‐dione: A Journey through their Synthesis, Biological Studies, and Optical Applications
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Renato L. Carvalho, Esther R S Paz, Marieli Oliveira Rodrigues, Eufrânio N. da Silva Júnior, Gleiston G. Dias, Mateus P Nunes, and Fabiano Severo Rodembusch
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Biological studies ,010405 organic chemistry ,General Chemical Engineering ,Imidazoles ,General Chemistry ,Phenanthrenes ,Phenanthrene ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Biological property ,Materials Chemistry ,Molecule ,Imidazole ,Moiety ,Oxazoles ,Oxazole - Abstract
Diverse structural frameworks are found in natural compounds and are well known for their chemical and biological properties; such compounds include the imidazoles and oxazoles. Researchers worldwide are continually working on the development of methods for synthesizing new molecules bearing these basic moiety and evaluating their properties and applications. To expand the knowledge related to azoles, this review summarizes important examples of imidazole and oxazole derivatives from 1,2-dicarbonyl compounds, such as lapachones and phenanthrene-9,10-diones, not only regarding their synthesis and biological applications but also their photophysical properties and uses. The data concerning the latter are particularly scarce in the literature, which leads to underestimation of the potential applications that can be envisaged for these compounds.
- Published
- 2021
29. Production and characterization of the solid product of coconut pyrolysis
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M. L. G. Santos, E. C. S. Paz, G. G. Silva, C. F. Paschoalato, Luciana Rezende Alves de Oliveira, M. M. Pedroza, and M. G. Arruda
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Renewable Energy, Sustainability and the Environment ,Chemistry ,020209 energy ,Thermal decomposition ,Langmuir adsorption model ,chemistry.chemical_element ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,symbols.namesake ,chemistry.chemical_compound ,Adsorption ,visual_art ,Specific surface area ,0202 electrical engineering, electronic engineering, information engineering ,visual_art.visual_art_medium ,symbols ,Charcoal ,Carbon ,Pyrolysis ,Methylene blue ,0105 earth and related environmental sciences ,Nuclear chemistry - Abstract
In this present study, it aimed to characterize biomass and obtain charcoal by means of pyrolysis of Cocos nucifera L. from a fractional planning 24-1 to be used in the removal of methylene blue. The investigated effects were temperature of 500 and 550 °C, heating rate 10 and 20 °C/ min, gas flow 1 and 4 mL/ min, and time of 30 and 60 min. The biomass composition showed values for cellulose 36%, hemicellosis 11.2%, lignin 32.1%, calorific value of 17.5 MJKg-1, density 0.158 g / mL, carbon 45.1%, hydrogen 6.8%, oxygen 0.4%, and nitrogen 47.7%. The results indicate that among the investigated effects, only the temperature influenced the charcoal yield. The best yield was at 500 °C with a specific surface area of 30.3801m2/ g, a maximum methylene blue adsorption capacity of 67.7%, and better fit to the Langmuir isotherm model with a correlation coefficient R2 = 0.9804. Regarding thermal analysis, it was observed that above 250 °C lignocellulosic thermal decomposition begins. The charcoal presented uniform size and pores, which influenced the adsorptive process of removing methylene blue.
- Published
- 2021
30. P-020 Influence of vanadium and lead in seminal fluid on assisted reproductive techniques
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R Rodriguez Díaz, R Blanes-Zamora, J Gomez-Rodriguez, L Alcaide Ruggiero, A Hardisson, D Gonzalez-Weller, A.J Gutierrez, S Paz, C Rubio, and E Gonzalez-Davila
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Reproductive Medicine ,Rehabilitation ,Obstetrics and Gynecology - Abstract
Study question In recent decades there has been an increase in environmental contaminants than can affect assisted reproduction techniques. We analyze the influence of vanadium (V) and lead (Pb) on these results. Summary answer Higher seminal fluid V levels affect fertilization rate (FR). Higher Pb and V levels decrease embryo cleavage rate (CR). What is known already Some animal studies have shown that V produces toxicity in the male reproductive system through oxidative stress, and this leads to decreases sperm count and motility, as well increased concentration of abnormal sperm. Pb is one of the main pollutants and, it accumulates in the male reproductive organs, deteriorates the quality of semen, increases the frequency of spontaneous abortion and male infertility. And it has also been seen that it inhibits sperm functions in vitro, although its mechanism of action is still unknown. Study design, size, duration A prospective study was conducted in 102 males, with a mean age of 38.0 ± 5.7, attended successively for initial evaluation, in the Human Reproduction Unit of the Hospital Universitario de Canarias, between february and april 2018, who underwent a semen analysis and metal detection and, subsequently, an IVF/ICSI treatment during years 2019 and 2020 (n = 92). The relationship between the presence of metals and the results of ART has been established. Participants/materials, setting, methods We included two groups based on semen parameters: 41 patients with pathological spermiograms (40.2%), while the remaining 61 (59.8%) had a normal semen analysis and constituted the control group.The study of seminal parameters was performed according to the WHO guidelines. The metals analysis was carried out in the Toxicology Area of the Universidad de La Laguna, using the digestion for microwave method. Metal measurement was performed using inductively coupled plasma optical emission spectrometry (ICP-OES). Main results and the role of chance In our study we have observed 79.4% of patients have V in semen. Significant differences have been found in the concentration of V in semen (t100=1.988, p = 0.05), is higher in patients who drink alcohol (0.51± 0.40 mg/Kg) than in abstinent patients (0.35± 0.30 mg/Kg). The group with FR above 75% presented lower V values compared to those with rates below 75% (p = 0.039). Within this last group, 33.3% present V values higher than 0.7 mg / kg compared to 15.8% who present it in the group with FR greater than 75% (OR = 2.67 CI95% 1.01, 7.52; p = 0.048). A statistical relationship was found between CR and Pb and V. Those who did not reach 100% CR presented higher Pb values (p = 0.052). Of them, 63.6% presented Pb compared to 38.5% in the group reaching 100% division. This same relationship was observed for V, with higher values in the group that did not reach 100% (p = 0.032), and V being present in 90.9% of the samples compared to 79.5% in the group reaching 100%. Limitations, reasons for caution The limitation of this study was the volume of semen that could be obtained for the metal detection, only 0.5 ml. This was because the semen sample was used at the same time to make a diagnosis of infertility though a spermiogram Wider implications of the findings The determination of metals in semen opens a new field in the study of infertility, and many cases of unknown infertility could due to metal presence or absence in seminal fluid, with the option of performing several treatments to correct these possible anomalies. Trial registration number not applicable
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- 2022
31. UHMK1 is a novel splicing regulatory kinase
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Vanessa C. Arfelli, Yun-Chien Chang, Johannes W. Bagnoli, Paul Kerbs, Felipe E. Ciamponi, Laissa M. S. Paz, Katlin B. Massirer, Wolfgang Enard, Bernhard Kuster, Philipp A. Greif, and Leticia Fröhlich Archangelo
- Abstract
The U2AF Homology Motif Kinase 1 (UHMK1) is the only kinase that contains the U2AF homology motif (UHM), a common protein interaction domain among splicing factors. Through this motif, UHMK1 interacts with the splicing factors SF1 and SF3B1, known to participate in the 3’ splice site recognition during the early steps of spliceosome assembly. Although UHMK1 phosphorylates these splicing factors in vitro, the involvement of UHMK1 in RNA processing has not previously been demonstrated. Here, we identify novel putative substrates of this kinase and evaluate UHMK1 contribution to overall gene expression and splicing, by integrating global phosphoproteomics, RNA-seq, and bioinformatics approaches. Upon UHMK1 modulation, 163 unique phosphosites were differentially phosphorylated in 117 proteins, of which 106 are novel potential substrates of this kinase. Gene Ontology (GO) analysis showed enrichment of terms previously associated with UHMK1 function, such as mRNA splicing, cell cycle, cell division and microtubule organization. The majority of the annotated RNA-related proteins are components of the spliceosome, but are also involved in several steps of gene expression. Comprehensive analysis of splicing showed that UHMK1 affected over 200 alternative splicing events. Moreover, splicing reporter assay further supported UHMK1 function on splicing. Overall, RNA-seq data demonstrated that UHMK1 knockdown had a minor impact on gene expression and pointed to UHMK1 function in epithelial-mesenchymal transition. Finally, the functional assays demonstrated that UHMK1 modulation affects proliferation, colony formation, and migration of the cells. Taken together, our data implicate UHMK1 as a splicing regulatory kinase, connecting protein regulation through phosphorylation and gene expression in key cellular processes.
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- 2022
32. QUEM SABE O PRÍNCIPE VIROU UM PERIGO: A RELAÇÃO ABUSIVA EM A MEGERA DOMADA
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J. S. PAZ and A. M. SANFELICI
- Abstract
This article discusses the play The Taming of the Shrew, renowned comedy by William Shakespeare, starring a couple whose relationship is, at least, problematic, but rather potentially dangerous. Taking into consideration concepts regarding the “romantic ideal” and healthy relationships, we outline the concept of abusive relationship, supported by the studies developed by McCarry (2010), Markey e Markey (2007) e Postmus, Stylianou e McMahon (2015). By recognizing the abusive relationship as different than the unhealthy one, singularly for its increased degree of violence (any type of violence, be it physical, emotional or psychological), we aim to promote a debate about the relationship between Katherina and Petruchio, focusing on the gender roles and power positions of each party of this relationship. We demonstrate the possibility to perceive this relationship as abusive, since Petruchio controls and blackmails his wife in several opportunities, including severe deprivations, in a dynamic that is far from a healthy relationship.
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- 2021
33. The Effects of the Chinese Imports on Brazilian Manufacturing Workers
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Lourenço S. Paz and Kul Prasad Kapri
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Brazil ,China ,employment ,import penetration ,manufacturing ,wages ,Economics as a science ,HB71-74 - Abstract
This study examines the impacts of imports from China and from the Rest of the World (ROW) on the wages of Brazilian manufacturing workers during 2000−2012. In this period, import penetration in Brazil grew by 25 percent, and the Chinese share of it increased from 3 to 20 percent. Using household survey data that encompass both formal and informal workers, we find that imports from China and from the ROW had different effects on manufacturing skilled and unskilled workers’ wages. Both the skilled and unskilled workers were negatively affected by an increase in the Chinese import penetration of intermediate inputs. For skilled workers, the ROW import penetration effect was negative for labor-intensive industries and positive for the other industries, while the Chinese import penetration had a positive effect on skilled workers’ wages. For the unskilled workers, we find that those in unskilled-labor intensive industries experienced positive impacts from both China and ROW import penetrations, whereas larger import penetrations reduced the wages for unskilled workers in the other industries.
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- 2019
- Full Text
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34. A comprehensive study of the reduction of nitrate on natural FeTiO3: Photocatalysis and DFT calculations
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Jefferson E. Silveira, Aramille S. de Souza, Fernando N.N. Pansini, Alyson R. Ribeiro, Wanderlã L. Scopel, Juan A. Zazo, Jose A. Casas, and Wendel S. Paz
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Filtration and Separation ,Analytical Chemistry - Published
- 2023
35. A Rare and Fatal Case of Aortobronchial Fistula Secondary to Disseminated Tuberculous Aortitis and Takayasu Arteritis
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Bryan Rene F. Toledano, Joel S. Paz, Glenn Valloso, Leonisa S. Sagun, Teresita De Guia, Paul P. Salandanan, Vanessa Yu Ma., and Therese Eileen B. Lladoc-Natividad
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medicine.medical_specialty ,business.industry ,Takayasu arteritis ,cardiovascular system ,Medicine ,cardiovascular diseases ,General Medicine ,Radiology ,Aortobronchial fistula ,business ,medicine.disease ,Aortitis - Abstract
BACKGROUND Aortobronchial fistula (ABF) is a rare complication of a chronic thoracic aneurysm. An ABF secondary to Disseminated Tuberculous (TB) Aortitis and Takayasu Arteritis (TA) may present with extensive combinations of aneurysms and stenoses in different parts of the arterial system with involvement of other organs. CASE PRESENTATION A 29-year-old Filipino female, married, who was admitted to our institution due to sudden massive hemoptysis. A Computed Tomography of the chest showed pulmonary tuberculosis with lymph node involvement and pseudoaneurysm of the descending aorta. The pertinent physical examinations are blood pressure (BP) differential of 20mmhg of upper extremities, painless multiple nodular tongue, multiple cervical, and supraclavicular lymphadenopathies, grade 3/6 holosystolic murmur. On Computed Tomography of the aorta, there are combinations of aneurysms of the mid to distal descending thoracic aorta, distal abdominal aorta, superior mesenteric artery with stenoses of the subclavian and left renal arteries. She was immediately started on anti-TB medications, corticosteroids and was scheduled for aortic aneurysmal repair. However, there was a recurrence of massive hemoptysis leading to her demise. An autopsy of the thorax and abdomen revealed an acute pulmonary hemorrhage, aortobronchial fistula secondary to Disseminated Tuberculous Aortitis and Takayasu Arteritis. CONCLUSION A masked ABF should be suspected in a patient with massive hemoptysis and a pseudoaneurysm of the descending aorta. In a young female with disseminated TB aortitis, a concomitant TA should be investigated. Both can share the same clinical, radiological and pathologic features. It is fatal and needs prompt surgical or endovascular intervention.
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- 2020
36. Measuring illicit financial flows: A gravity model approach to estimate international trade misinvoicing
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Lourenço S. Paz
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- 2022
37. Early Systemic Glycolytic Shift After Aneurysmal Subarachnoid Hemorrhage is Associated with Functional Outcomes
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Aaron M. Gusdon, Chenlian Fu, Vasanta Putluri, Atzhiry S. Paz, Hua Chen, Xuefang Ren, Mohammed Khurshidul Hassan, Pramod Dash, Cristian Coarfa, Nagireddy Putluri, Huimahn A. Choi, and Jude P. J. Savarraj
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Fumarates ,Glutamine ,Humans ,Ketoglutaric Acids ,Neurology (clinical) ,Citrates ,Subarachnoid Hemorrhage ,Critical Care and Intensive Care Medicine ,Glycolysis - Abstract
Aneurysmal subarachnoid hemorrhage (aSAH) leads to a robust systemic inflammatory response. We hypothesized that an early systemic glycolytic shift occurs after aSAH, resulting in a unique metabolic signature and affecting systemic inflammation.Control patients and patients with aSAH were analyzed. Samples from patients with aSAH were collected within 24 h of aneurysmal rupture. Mass spectrometry-based metabolomics was performed to assess relative abundance of 16 metabolites involved in the tricarboxylic acid cycle, glycolysis, and pentose phosphate pathway. Principal component analysis was used to segregate control patients from patients with aSAH. Dendrograms were developed to depict correlations between metabolites and cytokines. Analytic models predicting functional outcomes were developed, and receiver operating curves were compared.A total of 122 patients with aSAH and 38 control patients were included. Patients with aSAH had higher levels of glycolytic metabolites (3-phosphoglycerate/2-phosphoglycerate, lactate) but lower levels of oxidative metabolites (succinate, malate, fumarate, and oxalate). Patients with higher clinical severity (Hunt-Hess Scale score ≥ 4) had higher levels of glyceraldehyde 3-phosphate and citrate but lower levels of α-ketoglutarate and glutamine. Principal component analysis readily segregated control patients from patients with aSAH. Correlation analysis revealed distinct clusters in control patients that were not observed in patients with aSAH. Higher levels of fumarate were associated with good functional outcomes at discharge (odds ratio [OR] 1.76, 95% confidence interval [CI] 1.15-2.82) in multivariable models, whereas higher levels of citrate were associated with poor functional outcomes at discharge (OR 0.36, 95% CI 0.16-0.73) and at 3 months (OR 0.35, 95% CI 0.14-0.81). No associations were found with delayed cerebral ischemia. Levels of α-ketoglutarate and glutamine correlated with lower levels of interleukin-8, whereas fumarate was associated with lower levels of tumor necrosis factor alpha.Aneurysmal subarachnoid hemorrhage results in a unique pattern of plasma metabolites, indicating a shift toward glycolysis. Higher levels of fumarate and lower levels of citrate were associated with better functional outcomes. These metabolites may represent targets to improve metabolism after aSAH.
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- 2022
38. Precarization or Protection? The Role of Trade and Labour Policies on Informality
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Rita K. Almeida, Lourenço S. Paz, and Jennifer P. Poole
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Development - Abstract
Several episodes of market-oriented reforms in developing countries have been accompanied by a significant rise in work outside of the formal economy. This paper investigates whether the impact of trade on formal employment is mediated by the strength of labour regulations. We rely on data from the Brazilian Census that provides information on workers' demographics and employment, including job formality status. Our estimation strategy exploits quasi-exogenous changes in industry-level real exchange rates to explore the likelihood of informality across employers exposed to varying degrees of de facto labour regulations. We further utilize two key features of Brazilian labour institutions – budgetary decisions about the availability of resources occur at the federal level, while decisions about where to inspect occur at the local level – to instrument for labour enforcement. Our results suggest that strict labour regulations may lead to a precarization of employment, rather than offering protection for workers.
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- 2022
- Full Text
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39. Effect of progressive irrigation water reductions on super-high-density olive orchards according to different scarcity scenarios
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M.A. Martínez-Gimeno, A. Zahaf, E. Badal, S. Paz, L. Bonet, and J.G. Pérez-Pérez
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Yields ,Soil Science ,Vegetative growth ,F06 Irrigation ,Olive orchards ,Regulated deficit irrigation ,Irrigation management ,Super-high-density cultivation ,Olive yield ,Oil yield ,F40 Plant ecology ,Agronomy and Crop Science ,Earth-Surface Processes ,Water Science and Technology ,Arbequina - Abstract
The cultivation of super-high-density (SHD) olive orchards in the Mediterranean Basin usually faces drought events due especially to low precipitation, high temperature and solar radiation in summer. Hence regulated deficit irrigation (RDI) strategies can be a useful tool for irrigation management to limit yield loss. Therefore, this work aimed to find the most suitable RDI strategy by placing special emphasis on phase II of fruit growth for SHD olive orchards irrigated below theoretical water requirements. Four irrigation strategies were defined according to different water availability scenarios: fully-irrigated, RDI1, RDI2 and RDI3, scaled to respectively supply 450, 350, 250 and 150 mm year-1. Tree water relations, trunk growth, fruit and oil yields, were evaluated. The study was carried out for 5 years in an ‘Arbequina’ commercial orchard (1667 trees ha-1) in Villena, Alicante (Spain). The main results showed that ‘Arbequina’ tree irrigation water productivity (both olive and oil) gradually increased as irrigation dose lowered. Olive yield depended heavily on the applied irrigation dose, with the highest olive yield for the Control trees. However, the oil yield in the RDI1 trees was similar to that of the Control trees, but strategies RDI2 and RDI3 reduced yield. All the RDI strategies diminished vegetative development, and RDI2 was the most efficient strategy for resource distribution (olive yield vs. vegetative growth). Therefore based on oil production, vegetative growth and irrigation water savings, RDI1 was the most recommendable irrigation strategy for the Arbequina’ olive trees cultivated in SHD under semi-arid Mediterranean conditions.
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- 2022
40. Effects of charged particles on human tumor cells
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Kathryn D Held, Hidemasa eKawamura, Takuya eKaminuma, Athena Evalour S. Paz, Yukari eYoshida, Qi eLiu, Henning eWillers, and Akihisa eTakahashi
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Hypofractionation ,Proton therapy ,cancer stem cells (CSCs) ,charged particles ,Carbon ion therapy ,relative biological effectiveness (RBE) ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The use of charged particle therapy in cancer treatment is growing rapidly, in large part because the exquisite dose localization of charged particles allows for higher radiation doses to be given to tumor tissue while normal tissues are exposed to lower doses and decreased volumes of normal tissues are irradiated. In addition, charged particles heavier than protons have substantial potential clinical advantages because of their additional biological effects including greater cell killing effectiveness, decreased radiation resistance of hypoxic cells in tumors and reduced cell cycle dependence of radiation response. These biological advantages depend on many factors such as endpoint, cell or tissue type, dose, dose rate or fractionation, charged particle type and energy, and oxygen concentration. This review summarizes the unique biological advantages of charged particle therapy and highlights recent research and areas of particular research needs, such as quantification of Relative Biological Effectiveness (RBE) for various tumor types and radiation qualities, role of genetic background of tumor cells in determining response to charged particles, sensitivity of cancer stem-like cells to charged particles, role of charged particles in tumors with hypoxic fractions and importance of fractionation, including use of hypofractionation, with charged particles.
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- 2016
- Full Text
- View/download PDF
41. The Effects of Chinese Imports on Female Workers in the Brazilian Manufacturing Sector
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Lourenço S. Paz and John Ssozi
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Labour economics ,050204 development studies ,Taste (sociology) ,media_common.quotation_subject ,05 social sciences ,Development ,Manufacturing sector ,Rest (finance) ,0502 economics and business ,Penetration (warfare) ,Business ,China ,health care economics and organizations ,media_common - Abstract
This study uses the Becker’s (1957) taste-based discrimination model to analyse the effects of import penetration from China and from the Rest of the World (ROW) on the share of female workers and on the male-female wage gap in the manufacturing sector of Brazil. Using 2000-2012 data from the Brazilian Censuses and Pesquisa Nacional por Amostra de Domicílios, this paper finds no effect of the industry-level exports share on these outcomes. The Chinese import penetration increased the female share and narrowed the male-female wage gap except for college educated workers. The ROW import penetration raised the female share among workers with college degrees, but widened the wage gap except for those with college degrees. These effects were modified with the implementation of the Nova Matriz Econômica (NME) policy in 2008. During the post-NME regime, Chinese import penetration reduced the female share across all workers’ groups, while the negative effects of ROW increased on the female share of all groups and on the wage gap in the unskilled-labour intensive industries except for the workers with college degrees. Hence, the effects of the heightened trade-induced competition on workers’ discrimination depends on the type and source of imports, the education of workers, and the domestic policies, specifically on wages and sectoral subsidies.
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- 2020
42. Prevalence and incidence of systemic lupus erythematosus in Tucumán, Argentina
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Gustavo A Carrizo, Hector R Sueldo, Alberto Y Torres, Rodolfo Dip, Ana C Olea, Norma Robles, Gustavo Arquez, Gladys Seleme, Maximiliano Machado Escobar, S Paz, Verónica Bellomio, Olga Romano, Mirta Santana, L. M. Galindo, Doralia L Vasquez, Alexia Cristofari, Silvia Rengel, Laura A Juarez, A. L. Barbaglia, Luciana González Lucero, E Lucero, Maria J Molina, Oscar L Pera, F Colombres, Maria C Bertolaccini, Mariana Espindola Echazu, Ana Quinteros, Maria O Leal, Hector Lazaro, and M S Yacuzzi
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,business.industry ,Incidence ,Incidence (epidemiology) ,Argentina ,Dermatology ,Young Adult ,Age Distribution ,Rheumatology ,Prevalence ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Female ,Sex Distribution ,business - Abstract
The aim of this study was to determine the prevalence and incidence of Systemic Lupus Erythematosus (SLE) in Tucumán, Argentina. Methods: The study included inpatient and outpatient charts from four public hospitals and private practice rheumatology clinics, all of them members of the Tucumán Rheumatology Society. Patients older than 16 years with diagnosis of SLE between January 2005 and December 2012 were included. Prevalence and annual incidence were calculated as the number of cases per 100.000 inhabitants during the period 2005 to 2012. Results: Three hundred fifty-three patients were identified. The mean age at diagnosis was 30.5 ± 11.7 years, 93.5% women, 83% mestizos. Prevalence was 24.3 cases/100.000 inhabitants (CI 95% 22.6–28.8) and age-adjusted (≥16 years) of 34.9 cases/100.000 inhabitants (CI 95% 32.8–41.1). The annual incidence in 2005 was 1.8 cases/100.000 inhabitants (95% CI 1–2.9) and 2012 of 4.2 cases/100.000 inhabitants (95% CI 2.9–5.8). Mortality was 9.1%, with infections being the most frequent cause (14/32). Conclusion: The prevalence of SLE in the province of Tucumán was 34.9 cases/100.000 inhabitants.
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- 2020
43. Tuning the photocatalytic water-splitting capability of two-dimensional α-In2Se3 by strain-driven band gap engineering
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Wanderlã L. Scopel, Erik F. Procopio, Fábio A. L. de Souza, Renan N. Pedrosa, and Wendel S. Paz
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Materials science ,Hydrogen ,Band gap ,business.industry ,General Physics and Astronomy ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Condensed Matter::Materials Science ,Semiconductor ,chemistry ,Chemical physics ,Water splitting ,Density functional theory ,Direct and indirect band gaps ,Physical and Theoretical Chemistry ,0210 nano-technology ,Ground state ,business ,Photocatalytic water splitting - Abstract
In this work, we have investigated the effects of in-plane mechanical strains on the electronic properties of single-layer α-In2Se3 by means of density functional theory (DFT) calculations. Our findings reveal that this system exhibits a semiconductor character with an indirect band gap in the ground state, with a compressive biaxial strain leading to an indirect to direct band gap transition. Remarkably, along with the band gap transition, the system displays promising capability to produce hydrogen gas from a visible light photocatalytic water splitting process.
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- 2020
44. Pain and Other Neurological Symptoms Are Present at 3 Months After Hospitalization in COVID-19 Patients
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Atzhiry S Paz, Gabriela D. Colpo, Sarah N Hinds, Sung Min Cho, Angela B. Burkett, Shivanki Juneja, Louise D. McCullough, Aaron M. Gusdon, Jude P.J. Savarraj, Andres Assing, Luis F. Torres, and H. Alex Choi
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Pediatrics ,medicine.medical_specialty ,Cognitive Symptoms ,Coronavirus disease 2019 (COVID-19) ,Hospitalized patients ,business.industry ,Public health ,Neurological function ,COVID-19 ,long-haul ,neurological symptoms ,Cognition ,Pandemic ,medicine ,General Earth and Planetary Sciences ,pain ,fatigue ,Neurology. Diseases of the nervous system ,RC346-429 ,business ,General Environmental Science ,Pain symptoms - Abstract
COVID-19 is an ongoing pandemic with a devastating impact on public health. Acute neurological symptoms have been reported after a COVID-19 diagnosis, however, the long-term neurological symptoms including pain is not well established. Using a prospective registry of hospitalized COVID-19 patients, we assessed pain and neurological function (including functional, cognitive and psychiatric assessments) of several hospitalized patients at 3 months. Our main finding is that 60% of the patients report pain symptoms. 71% of the patients still experienced neurological symptoms at 3 months and the most common symptoms being fatigue (42%) and PTSD (25%). Cognitive symptoms were found in 12%. Our preliminary findings suggests the importance of investigating long-term outcomes and rationalizes the need for further studies investigating the neurologic outcomes and symptoms of pain after COVID-19.
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- 2021
45. Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19
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Louise D. McCullough, Sung Min Cho, Fudong Liu, Diego Morales, Eun Sook Park, H. Alex Choi, Aaron M. Gusdon, Jude P.J. Savarraj, Pramod K. Dash, Eunhee Kim, Sarah N Hinds, Shivanki Juneja, Hilda Ahnstedt, Andres Assing, Gabriela D. Colpo, and Atzhiry S Paz
- Subjects
Oncology ,Adult ,Male ,medicine.medical_specialty ,Chemokine ,medicine.medical_treatment ,Immunology ,Inflammation ,Severity of Illness Index ,Endothelial injury ,Cellular and Molecular Neuroscience ,Sex Factors ,Internal medicine ,Sex differences ,medicine ,Humans ,Interleukin 8 ,Endothelium ,Brain injury ,RC346-429 ,Aged ,Sex Characteristics ,biology ,business.industry ,SARS-CoV-2 ,General Neuroscience ,Research ,Respiratory disease ,COVID-19 ,Middle Aged ,medicine.disease ,Hospitalization ,Interleukin 10 ,Cytokine ,Neurology ,Brain Injuries ,Cohort ,biology.protein ,Cytokines ,Tumor necrosis factor alpha ,Female ,Neurology. Diseases of the nervous system ,medicine.symptom ,business ,Biomarkers - Abstract
Objective Although COVID-19 is a respiratory disease, all organs can be affected including the brain. To date, specific investigations of brain injury markers (BIM) and endothelial injury markers (EIM) have been limited. Additionally, a male bias in disease severity and mortality after COVID-19 is evident globally. Sex differences in the immune response to COVID-19 may mediate this disparity. We investigated BIM, EIM and inflammatory cytokine/chemokine (CC) levels after COVID-19 and in across sexes. Methods Plasma samples from 57 subjects at Results Three BIMs: MAP2, NSE and S100B, two EIMs: sICAM1 and sVCAM1 and seven CCs: GRO IL10, sCD40L, IP10, IL1Ra, MCP1 and TNFα were significantly (p p Conclusion The acute elevation of BIMs, CCs, and EIMs and the robust associations among them at COVID-19 hospitalization are suggestive of brain and endothelial injury. Higher BIM and inflammatory markers in men additionally suggest that men are more susceptible to the risk compared to women.
- Published
- 2021
46. Predicted functional and taxonomic analysis of subgingival biofilm of Grade C periodontitis in young patients under maintenance therapy
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Camila Schmidt Stolf, Márcio Zaffalon Casati, Purnima S. Kumar, Hélvis E. S. Paz, Renato Corrêa Viana Casarin, Mabelle Freitas Monteiro, and Khaled Altabtbaei
- Subjects
Periodontitis ,Treponema ,biology ,business.industry ,Microbiota ,Biofilm ,High-Throughput Nucleotide Sequencing ,Disease ,medicine.disease ,biology.organism_classification ,Maintenance therapy ,Biofilms ,RNA, Ribosomal, 16S ,Immunology ,medicine ,Periodontics ,Aggressive periodontitis ,Humans ,Periodontal Debridement ,Microbiome ,business - Abstract
Background In Grade C periodontitis in young patients (PerioC-Y), the functional roles of the subgingival community after years of periodontal treatment are still underexplored. This study evaluated the taxonomic and predicted functional content of the subgingival microbiome of PerioC-Y patients under supportive periodontal therapy (SPT). Methods Clinical and microbiological data from subgingival biofilm were assessed from 10 PerioC-Y patients at two time points: at baseline and after 5.7±1.3 years of SPT. This was compared to 15 patients without a history of periodontitis. The V1-V3 and V4-V5 regions of the 16S rRNA were sequenced using the Illumina Miseq. Microbial composition was evaluated by the core microbiome, and alpha- and beta-diversity. The microbiome functional content was predicted using Picrust2, and the gene differential abundance was analyzed with DESeq2. Results Clinical improvements were seen in PerioC-Y-SPT. Differences in β-diversity between PerioC-Y and Health were observed (Health x PerioC-Y-baseline, p = 0.02; Health x PerioC-Y-SPT, p = 0.05). Moreover, although β-diversity did not statistically change between baseline and SPT in PerioC-Y, the microbial correlation evidenced increased Streptococcus and decreased Treponema network contributions during SPT. Based on predicted functional data, treatment induced a reduction in genes related to flagellar protein and signal transduction in PerioC-Y. However, compared to healthy individuals, some genes remained more highly abundant in PerioC-Y-SPT, such as quorum sensing and efflux pump transporters. Conclusion Despite clinical improvements and a shift in taxonomic composition, the PerioC-Y patients' periodontal treatment was not enough to reach a similar microbiome to patients without disease experience. Some functional content in this biofilm remained altered in PerioC-Y regardless of disease control. This article is protected by copyright. All rights reserved.
- Published
- 2021
47. Peritonitis tuberculosa en pacientes infectados por el virus de la inmunodeficiencia humana Tuberculous peritonitis in HIV-infected patients
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D. Cecchini, S. Paz, S. Poggi, M. Robles, and M. Ambroggi
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Peritonitis ,Tuberculosis ,VIH ,Cirrosis ,Tuberculosis multirresistente ,Hepatitis C ,HIV ,Cirrhosis ,Multidrug resistant tuberculosis ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Con el objetivo de describir aspectos clínicos y de laboratorio de la peritonitis por Mycobacterium tuberculosis en pacientes VIH (+), se realizó un análisis retrospectivo de historias clínicas de pacientes VIH+ con aislamiento de M. tuberculosis de líquido ascítico (LA) atendidos en el período 1996-2005 en el Hospital Muñiz, Buenos Aires, Argentina. Se incluyeron 21 pacientes con una mediana de edad de 34 años; el 52% era de sexo masculino. La mediana del valor de linfocitos T CD4+ en sangre periférica fue de 85/mm³; la tasa de pacientes con tuberculosis previa alcanzó el 40%; mientras que la proporción de sujetos con cuadro clínico compatible con cirrosis, con enolismo y con serología reactiva al virus de la hepatitis C (VHC) fue del 65%, 45% y 85%, respectivamente. Los síntomas más frecuentes fueron la distensión abdominal (71%), la fiebre (62%) y el dolor abdominal (19%). Las características químicas (medianas) del LA fueron las siguientes: recuento de leucocitos: 751/mm³ (predominio mononuclear: 79%); proteínas: 3,1 g/dl; LDH: 351 UI/l. Se obtuvo baciloscopía positiva en el LA del 14% de los enfermos y se comprobó infección por M. tuberculosis multirresistente (TBC-MR) en el 20%. Se aisló M. tuberculosis de otras muestras en el 71% de los casos. Quince pacientes recibieron tratamiento antituberculoso; en el 30% el tratamiento empírico inicial no se adecuó a la sensibilidad de la cepa. La mortalidad global fue del 66,4%, lo que se considera un valor elevado. Esto sería atribuible a la alta frecuencia de TBC-MR, al grado de inmunosupresión y a la prevalencia de cirrosis secundaria a enolismo y de coinfección por el VHC.In order to describe the clinical and laboratory findings of Mycobacterium tuberculosis peritonitis M. tuberculosis in HIV+ patients, we conducted a retrospective analysis of the medical records of HIV+ patients with isolation of M. tuberculosis from ascitic fluid (AF), assisted at Hospital Muñiz, Buenos Aires, Argentina (1996-2005). Results: 21 patients were included. Median age: 33, male sex: 52%; peripheral blood CD4-T lymphocyte count (median): 85/mm³; prior history of tuberculosis: 40%; cirrhosis: 65%; enolism: 45%; HCV coinfection: 85%. The most frequent symptoms were abdominal distension (71%), fever (62%) and abdominal pain (19%). The chemical characteristics of the AF were (median): leukocyte count: 751/mm³ (mononuclear predominance: 79%), protein: 3.1 g/dl, LDH: 351 IU/l. AF samples positive for acid fast bacilli at direct microscopic examination: 14%. Infection with multidrug resistant M. tuberculosis (TB-MR): 20%. M. tuberculosis was isolated from other clinical samples in 79%. Fifteen patients received treatment for tuberculosis; in 30% of cases, it was not appropriate due to the susceptibility of the isolated strain. Overall mortality was 66.4%. Conclusion: high mortality was observed, which may be attributable to the high frequency of TB-MR, the level of immunosuppression and the prevalence of cirrhosis secondary to enolism and/or HCV coinfection.
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- 2010
48. Auto-anticorpos anti-LDLox e sua correlação com o perfil lipídico e o estado nutricional de adolescentes Anti-oxLDL autoantibodies and their correlation with lipid profile and nutritional status in adolescents
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Leticia B. Sanches, Isis T. da Silva, Aline F. S. Paz, Mauro Fisberg, Isa P. Cintra, Betzabeth S. Villar, and Nágila R. T. Damasceno
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Auto-anticorpos anti-LDLox ,perfil lipídico ,antropometria e adolescentes ,Anti-oxLDL autoantibodies ,lipid profile ,anthropometry and adolescents ,Pediatrics ,RJ1-570 - Abstract
OBJETIVO: Avaliar se o conteúdo de auto-anticorpos anti-LDL oxidada (anti-LDLox) no plasma de adolescentes correlaciona-se com suas medidas antropométricas e com o perfil lipídico. MÉTODOS: O estudo incluiu 150 adolescentes com idade entre 10 e 15 anos, recrutados do ambulatório de obesidade da Universidade Federal de São Paulo (SP) e de escolas públicas de Piracicaba (SP). Foram avaliadas medidas antropométricas, como índice de massa corporal, circunferência de cintura e do braço, classificando os adolescentes em eutrófico, sobrepeso e obeso. Para as análises bioquímicas, foi realizado o perfil lipídico através de métodos enzimáticos colorimétricos, e para detecção do conteúdo de auto-anticorpos anti-LDLox, utilizou-se o método de ELISA. RESULTADOS: Segundo análises das variáveis antropométricas, o grupo obeso apresentou perfil alterado em relação aos grupos eutrófico e sobrepeso (p < 0,01), indicando risco cardiovascular. Quando o perfil lipídico foi avaliado, observaram-se diferenças estatisticamente significativas para as concentrações de colesterol total (p = 0,011), HDL-colesterol (p = 0,001) e LDL-colesterol (p < 0,042) nos grupos eutrófico e obeso. Para as análises de auto-anticorpos anti-LDLox plasmática, os grupos sobrepeso (p = 0,012) e obeso (p < 0,001) apresentaram valores superiores ao grupo eutrófico. Também houve correlações entre os auto-anticorpos anti-LDLox e variáveis antropométricas. CONCLUSÃO: A presença de auto-anticorpos anti-LDLox em adolescentes e as alterações metabólicas no perfil lipídico variaram de modo proporcional com parâmetros antropométricos, o que torna o conteúdo de anti-LDLox um potencial indicador bioquímico de risco para síndrome metabólica.OBJECTIVE: To investigate whether levels of autoantibodies to oxidized LDL (anti-oxLDL) in the plasma of adolescents correlates with their anthropometric measurements and lipid profiles. METHODS: The study enrolled 150 adolescents aged between 10 and 15 years, recruited from the obesity clinic at Universidade Federal de São Paulo (SP) and from public schools in Piracicaba, SP, Brazil. Anthropometric measurements such as body mass index and waist and arm circumferences were used to classify the adolescents as having healthy weight, overweight or obesity. Colorimetric enzymatic methods were used for biochemical lipid profile analysis and ELISA was used to determine anti-oxLDL autoantibody levels. RESULTS: Analysis of anthropometric variables indicated that the obese group's profile was abnormal compared to the healthy weight and overweight groups (p < 0.01), indicating cardiovascular risk. Analysis of the lipid profiles demonstrated statistically significant differences in concentrations of total cholesterol (p = 0.011), HDL-cholesterol (p = 0.001) and LDL-cholesterol (p < 0.042) between the healthy weight group and the obese group. Analysis of plasma anti-oxLDL autoantibodies demonstrated that the overweight (p = 0.012) and obese groups (p < 0.001) had higher values than the healthy weight group. There were also correlations between anti-oxLDL autoantibody levels and anthropometric variables. CONCLUSIONS: In adolescents the presence of anti-oxLDL autoantibodies and metabolic changes to the lipid profile vary in proportion with anthropometric parameters, which makes anti-oxLDL concentration a potential biochemical indicator of risk of metabolic syndrome.
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- 2008
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49. IL10 promoter rs6667202 polymorphism is functional in health but not in grade c periodontitis patients: A pilot study
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Renato Assis Machado, Catharina Marques Sacramento, Hélvis E. S. Paz, Karina Gonzales Silvério Ruiz, Mauro Pedrine Santamaria, Karina Cogo-Müller, Renato Corrêa Viana Casarin, Lucas de Paula Ramos, Luciane Dias de Oliveira, Camila Schmidt Stolf, Universidade Estadual de Campinas (UNICAMP), and Universidade Estadual Paulista (UNESP)
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Genotype ,Aggregatibacter ,Single-nucleotide polymorphism ,Pilot Projects ,Polymorphism, Single Nucleotide ,Andrology ,Gene Frequency ,Polymorphism (computer science) ,Biopsy ,Gene expression ,medicine ,Aggressive periodontitis ,Humans ,Genetic Predisposition to Disease ,Periodontitis ,Promoter Regions, Genetic ,biology ,medicine.diagnostic_test ,business.industry ,biology.organism_classification ,medicine.disease ,Interleukin-10 ,Case-Control Studies ,Periodontics ,business - Abstract
Made available in DSpace on 2022-04-29T08:34:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Background and objective: Previous studies have demonstrated an association between the IL10 promoter rs6667202 (C > A) single-nucleotide polymorphism (SNP) and grade C, stage 3 or 4 periodontitis (Perio4C) in the Brazilian population, where the altered A allele was detected more frequently in these patients. However, no functional analysis of this variation has yet been performed. Thus, the objective of this preliminary study was to evaluate the functionality of rs6667202 in gingival fibroblasts (GFs) of individuals with Perio4C and with periodontal health (PH) stimulated with Aggregatibacter actinomycetencomitans protein extract (AaPE). Methods: Patients with PH and Perio4C were segregated according to their genotype (AA, AC, or CC), and a biopsy was performed to establish the culture of the GFs. After GFs exposure to AaPE at 5 µg/ml for 1.5 h, RNA was extracted to analyze IL10 expression by qPCR. Aliquots of the cell's supernatant were subjected to immunoenzymatic analysis (MAGpix) to detect interleukin-10 (IL-10). Results: In PH, the genotypes AA and AC are related to less expression of IL10 (p = 0.027 and p 0.05), although a lower IL-10 expression and release compared with PH CC was seen (p = 0.033 and p
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- 2021
50. Few-layer antimonene electrical properties
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Lucia Aballe, José A. Martín-Gago, Julio Gómez-Herrero, Sahar Pakdel, Maedeh Rassekh, David Rodriguez San Miguel, Pablo Ares, Wendel S. Paz, Michael Foerster, Félix Zamora, Irene Palacio, Nerea Ruiz del Árbol, Juan Jose Palacios, UAM. Departamento de Física de la Materia Condensada, UAM. Departamento de Química Inorgánica, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), European Research Council, Comunidad de Madrid, and Fundación Ramón Areces
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media_common.quotation_subject ,Dirac (software) ,Library science ,FOS: Physical sciences ,02 engineering and technology ,Kelvin probe force microscopy ,01 natural sciences ,Excellence ,Antimonene ,Political science ,0103 physical sciences ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,General Materials Science ,010306 general physics ,Computer resources ,media_common ,Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Materials Science (cond-mat.mtrl-sci) ,Física ,021001 nanoscience & nanotechnology ,Antimony atoms ,Electronic properties ,Electrical properties ,Photoemission electron microscopy ,0210 nano-technology ,Few-layer - Abstract
[EN] Antimonene -a single layer of antimony atoms- and its few layer forms are among the latest additions to the 2D mono-elemental materials family. Numerous predictions and experimental evidence of its remarkable properties including (opto)electronic, energetic or biomedical, among others, together with its robustness under ambient conditions, have attracted the attention of the scientific community. However, experimental evidence of its electrical properties is still lacking. Here, we characterized the electronic properties of mechanically exfoliated flakes of few-layer (FL) antimonene of different thicknesses (∼ 2–40 nm) through photoemission electron microscopy, kelvin probe force microscopy and transport measurements, which allows us to estimate a sheet resistance of ∼ 1200 Ω sq−1 and a mobility of ∼ 150 cm2V−1s−1 in ambient conditions, independent of the flake thickness. Alternatively, our theoretical calculations indicate that topologically protected surface states (TPSS) should play a key role in the electronic properties of FL antimonene, which supports our experimental findings. We anticipate our work will trigger further experimental studies on TPSS in FL antimonene thanks to its simple structure and significant stability in ambient environments., We acknowledge financial support through the “María de Maeztu” Programme for Units of Excellence inR&D(CEX2018- 0 0 0805-M), the Spanish MINECO through projects PCI2018- 093081,FIS2016-80434-P, PID2019-109539GB-C43, PID2019- 106268GB-C31 and -C32,MAT2016-77608-C3-1-P and -3-P, MAT2013-46753-C2-2-P and MAT2017-85089-C2-1R,the EU Graphene Flagship funding (Graphene Flagship Core3 881603 and JTC2017/2D-Sb&Ge), the EU via the ERC-Synergy Program (GrantERC-2013-SYG-610256 NANOCOSMOS), the Comunidad Autónoma de Madrid through MAD2D-CM, S2018/NMT-4321 (NanomagCOST-CM) and the European Structural Funds via FotoArt- CM project (S2018/NMT-4367), and the Fundación Ramón Areces. J.J.P. acknowledges the computer resources and assistance pro- vided by the Centro de Computación Científica of the Universidad Autónoma de Madrid andthe RES. S.P. acknowledges financial support by the VILLUM FONDEN via the Centre of Excellence for Dirac Materials (Grant No. 11744).
- Published
- 2021
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