492 results on '"S Masi"'
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2. Overview of the Medium and High Frequency Telescopes of the LiteBIRD Satellite Mission
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L. Montier, B. Mot, P. de Bernardis, B. Maffei, G. Pisano, F. Columbro, J. E. Gudmundsson, S. Henrot-Versillé, L. Lamagna, J. Montgomery, T. Prouvé, M. Russell, G. Savini, S. Stever, K. L. Thompson, M. Tsujimoto, C. Tucker, B. Westbrook, P. A.R. Ade, A. Adler, E. Allys, K. Arnold, D. Auguste, J. Aumont, R. Aurlien, J. Austermann, C. Baccigalupi, A. J. Banda, R. Banerji, R. B. Barreiro, S. Basak, J. Beall, D. Beck, S. Beckman, J. Bermejo, M. Bersanelli, J. Bonis, J. Borrill, F. Boulanger, S. Bounissou, M. Brilenkov, M. Brown, M. Bucher, E. Calabrese, P. Campeti, A. Carones, F. J. Casas, A. Challinor, V. Chan, K. Cheung, Y. Chinone, J. F. Cliché, L. Colombo, J. Cubas, A. Cukierman, D. Curtis, G. D’Alessandro, N. Dachlythra, M. De Petris, C. Dickinson, P. Diego-Palazuelos, M. Dobbs, T. Dotani, L. Duband, S. Duff, J. M. Duval, K. Ebisawa, T. Elleflot, H. K. Eriksen, J. Errard, T. Essinger-Hileman, F. Finelli, R. Flauger, C. Franceschet, U. Fuskeland, M. Galloway, K. Ganga, J. R. Gao, R. Genova-Santos, M. Gerbino, M. Gervasi, T. Ghigna, E. Gjerløw, M. L. Gradziel, J. Grain, F. Grupp, A. Gruppuso, T. de Haan, N. W. Halverson, P. Hargrave, T. Hasebe, M. Hasegawa, M. Hattori, M. Hazumi, D. Herman, D. Herranz, C. A. Hill, G. Hilton, Y. Hirota, E. Hivon, R. A. Hlozek, Y. Hoshino, E. de la Hoz, J. Hubmayr, K. Ichiki, T. Iida, H. Imada, K. Ishimura, H. Ishino, G. Jaehnig, T. Kaga, S. Kashima, N. Katayama, A. Kato, T. Kawasaki, R. Keskitalo, T. Kisner, Y. Kobayashi, N. Kogiso, A. Kogut, K. Kohri, E. Komatsu, K. Komatsu, K. Konishi, N. Krachmalnicoff, I. Kreykenbohm, C. L. Kuo, A. Kushino, J. V. Lanen, M. Lattanzi, A.T. Lee, C. Leloup, F. Levrier, E. Linder, T. Louis, G. Luzzi, T. Maciaszek, D. Maino, M. Maki, S. Mandelli, E. Martinez-Gonzalez, S. Masi, T. Matsumura, A. Mennella, M. Migliaccio, Y. Minami, K. Mitsuda, G. Morgante, Y. Murata, J. A. Murphy, M. Nagai, Y. Nagano, T. Nagasaki, R. Nagata, S. Nakamura, T. Namikawa, P. Natoli, S. Nerval, T. Nishibori, H. Nishino, C. O’Sullivan, H. Ogawa, S. Oguri, H. Ohsaki, I. S. Ohta, N. Okada, L. Pagano, A. Paiella, D. Paoletti, G. Patanchon, J. Peloton, F. Piacentini, G. Polenta, D. Poletti, G. Puglisi, D. Rambaud, C. Raum, S. Realini, M. Reinecke, M. Remazeilles, A. Ritacco, G. Roudil, J. A. Rubino-Martin, H. Sakurai, Y. Sakurai, M. Sandri, M. Sasaki, D. Scott, J. Seibert, Y. Sekimoto, B. Sherwin, K. Shinozaki, M. Shiraishi, P. J. Shirron, G. Signorelli, G. Smecher, R. Stompor, H. Sugai, S. Sugiyama, A. Suzuki, J. Suzuki, T. L. Svalheim, E. Switzer, R. Takaku, H. Takakura, S. Takakura, Y. Takase, Y. Takeda, A. Tartari, E. Taylor, Y. Terao, H. Thommesen, B. Thorne, T. Toda, M. Tomasi, M. Tominaga, N. Trappe, M. Tristram, M. Tsuji, J. Ullom, G. Vermeulen, P. Vielva, F. Villa, M. Vissers, N. Vittorio, I. Wehus, J. Weller, J. Wilms, B. Winter, E. J. Wollack, N. Y. Yamasaki, T. Yoshida, J. Yumoto, M. Zannoni, and A. Zonca
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Instrumentation And Photography ,Astrophysics - Abstract
LiteBIRD is a JAXA-led Strategic Large-Class mission designed to search for the existence of the primordial gravitational waves produced during the inflationary phase of the Universe, through the measurements of their imprint onto the polarization of the cosmic microwave background (CMB). These measurements, requiring unprecedented sensitivity, will be performed over the full sky, at large angular scales, and over 15 frequency bands from 34 GHz to 448 GHz. The LiteBIRD instruments consist of three telescopes, namely the Low-, Medium- and High-Frequency Telescope (respectively LFT, MFT and HFT). We present in this paper an overview of the design of the Medium-Frequency Telescope (89–224 GHz) and the High-Frequency Telescope (166–448 GHz), the so-called MHFT, under European responsibility, which are two cryogenic refractive telescopes cooled down to 5 K. They include a continuous rotating half-wave plate as the first optical element, two high-density polyethylene (HDPE) lenses and more than three thousand transition-edge sensor (TES) detectors cooled to 100 mK. We provide an overview of the concept design and the remaining specific challenges that we have to face in order to achieve the scientific goals of LiteBIRD.
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- 2020
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3. Measuring CMB Spectral Distortions from Antarctica with COSMO: Blackbody Calibrator Design and Performance Forecast
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L. Mele, E. S. Battistelli, P. de Bernardis, M. Bersanelli, F. Columbro, G. Coppi, A. Coppolecchia, G. D’Alessandro, M. De Petris, C. Franceschet, M. Gervasi, L. Lamagna, A. Limonta, E. Manzan, E. Marchitelli, S. Masi, A. Mennella, F. Nati, A. Paiella, G. Pettinari, F. Piacentini, L. Piccirillo, G. Pisano, S. Realini, C. Tucker, M. Zannoni, Mele, L, Battistelli, E, de Bernardis, P, Bersanelli, M, Columbro, F, Coppi, G, Coppolecchia, A, D'Alessandro, G, De Petris, M, Franceschet, C, Gervasi, M, Lamagna, L, Limonta, A, Manzan, E, Marchitelli, E, Masi, S, Mennella, A, Nati, F, Paiella, A, Pettinari, G, Piacentini, F, Piccirillo, L, Pisano, G, Realini, S, Tucker, C, and Zannoni, M
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spectral distortions ,General Materials Science ,Blackbody ,cosmology ,Condensed Matter Physics ,Spectral distortion ,Atomic and Molecular Physics, and Optics ,Cosmology ,Spectral distortions - Abstract
COSMO is a ground-based instrument to measure the spectral distortions (SD) of the Cosmic Microwave Background (CMB). In this paper, we present preliminary results of electromagnetic simulations of its reference blackbody calibrator. HFSS simulations provide a calibrator reflection coefficient of $$R\sim 10^{-6}$$ R ∼ 10 - 6 , corresponding to an emissivity $$\epsilon =1-R=0.999999$$ ϵ = 1 - R = 0.999999 . We also provide a forecast for the instrument performance by using an ILC-based simulation. We show that COSMO can extract the isotropic Comptonization parameter (modeled as $$|y|=1.77 \cdot 10^{-6}$$ | y | = 1.77 · 10 - 6 ) as $$|y|=(1.79\pm 0.19)\cdot 10^{-6}$$ | y | = ( 1.79 ± 0.19 ) · 10 - 6 , in the presence of the main Galactic foreground (thermal dust) and of CMB anisotropies, and assuming perfect atmospheric emission removal.
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- 2022
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4. A New Readout Electronic for Kinetic Inductance Detectors
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A. Limonta, M. Zannoni, G. Coppi, G. Conenna, F. Boussaha, A. Tartari, M. Gervasi, F. Nati, A. Passerini, P. de Bernardis, A. Coppolecchia, G. D’Alessandro, S. Masi, A. Paiella, M. Bersanelli, C. Franceschet, E. Manzan, A. Mennella, Limonta, A, Zannoni, M, Coppi, G, Conenna, G, Boussaha, F, Tartari, A, Gervasi, M, Nati, F, Passerini, A, de Bernardis, P, Coppolecchia, A, D’Alessandro, G, Masi, S, Paiella, A, Bersanelli, M, Franceschet, C, Manzan, E, and Mennella, A
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FIS/05 - ASTRONOMIA E ASTROFISICA ,KIDS ,Electronic readout ,CMB ,Settore FIS/05 - Astronomia e Astrofisica ,General Materials Science ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics - Abstract
With this contribution we show the readout electronics for kinetic inductance detectors (KIDs) that we are developing based on commercial IQ transceivers from National Instruments and using a Virtex 5 class FPGA. It will be the readout electronics of the COSmic Monopole Observer (COSMO) experiment, a ground based cryogenic Martin–Puplett Interferometer searching for the cosmic microwave background spectral distortions. The readout electronics require a sampling rate in the range of tens of kHz, which is both due to a fast rotating mirror modulating the signal and the time constant of the COSMO KIDs. In this contribution we show the capabilities of our readout electronics using Niobium KIDs developed by Paris Observatory for our 5 K cryogenic system. In particular, we demonstrate the capability to detect 23 resonators from frequency sweeps and to readout the state of each resonator with a sampling rate of about 8 kHz. The readout is based on a finite-state machine where the first two states look for the resonances and generate the comb of tones, while the third one performs the acquisition of phase and amplitude of each detector in free running. Our electronics are based on commercial modules, which brings two key advantages: they can be acquired easily and it is relative simple to write and modify the firmware within the LabView environment in order to meet the needs of the experiment.
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- 2022
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5. Multi-organ sonographic assessment of congestion has incremental prognostic value in outpatients with heart failure irrespective of left ventricular ejection fraction
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N R Pugliese, P Pellicori, F Filidei, L Del Punta, N De Biase, A Balletti, V Di Fiore, A Mengozzi, S Taddei, L Gargani, W Mullens, J G F Cleland, and S Masi
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Epidemiology ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background Congestion is a key driver of symptoms, disease progression and prognosis for patients with heart failure (HF), irrespective of left ventricular ejection fraction (LVEF). However, clinically overt congestion is often undiagnosed unless severe. Recent research has shown that ultrasonographic quantification of systemic venous (i.e. inferior vena cava), renal venous and lung (B-lines) congestion is feasible and identifies HF patients with a worse prognosis. Purpose Whether a simultaneous multi-organ evaluation of congestion by ultrasound may improve risk stratification in HF is unknown. In the present study, we assessed signs of ultrasonographic congestion in the inferior vena cava, lungs and kidneys in HF patients across the LVEF spectrum and investigated their association with pathophysiology, clinical characteristics and prognosis. Methods We prospectively enrolled 326 patients with a prior clinical diagnosis of HF attending a routine follow-up visit. We also enrolled 102 consecutive patients with cardiovascular risk factors (including hypertension, type II diabetes mellitus or chronic ischaemic heart disease) and no history of HF; these latter patients had NT-proBNP levels 50%, and were not taking loop diuretics. All patients underwent a complete clinical assessment, blood and urine tests, and an ultrasound evaluation. Ultrasound congestion was defined as inferior vena cava ≥21 mm, highest tertile of lung B-lines or discontinuous renal venous flow. Results The final population consisted of 310 HF patients (median age 77 years, median NT-proBNP 1037 ng/L, 51% with LVEF Conclusion Simultaneous assessment of pulmonary, systemic venous and kidney congestion by ultrasound identifies a high prevalence of sub-clinical congestion associated with poor outcomes in HF, irrespective of LVEF. The speed of investigation, along with the widespread availability and relatively low cost of ultrasound, makes this protocol easy to implement for real-time assessment of congestion.
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- 2023
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6. Functional and prognostic impact of hypertensive response to exercise across the heart failure spectrum
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N De Biase, L Del Punta, A Balletti, S Armenia, S Buralli, A Mengozzi, S Taddei, M Metra, M Pagnesi, B A Borlaug, B Williams, S Masi, and N R Pugliese
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Epidemiology ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background Conflicting data exist regarding the prognostic significance of hypertensive response to exercise (HRE), commonly defined according to absolute peak systolic blood pressure (SBP) values. Limited evidence is available regarding the impact of workload-indexed HRE in patients at different stages of the heart failure (HF) spectrum as defined by the American College of Cardiology/American Heart Association HF staging system. Purpose We evaluated the SBP/Workload slope during exercise across the HF spectrum and investigated the haemodynamic, functional and prognostic correlates of HRE. Methods We prospectively enrolled 58 healthy controls, 201 subjects at risk of developing HF (HF Stages A-B), and 369 patients with a definite diagnosis of HF (Stage C); among the latter, 143 had preserved (HFpEF) and 226 reduced (HFrEF) left ventricular ejection fraction. All patients underwent a combined cardiopulmonary-exercise stress echocardiography test. For each patient, we recorded the first (i.e., within the first minute of exercise) and last (i.e., at peak effort) BP measurement during the ramp protocol. The SBP/Workload slope (Figure 1) was calculated as the ratio of the difference in SBP over the corresponding increment in watts (W): (SBPpeak – SBPfirst)/(Wpeak – Wfirst). In each subgroup, we divided patients according to SBP/Workload slope tertiles; HRE was defined as the highest sex-specific SBP/Workload slope tertile in each HF stage. The primary outcome was a composite of all-cause mortality and hospitalization for cardiovascular reasons. Results Median SBP/Workload slope was 0.53 mmHg/W, interquartile range 0.36-0.72 mmHg/W; the slope was 39% steeper in women than in men (p Conclusion HRE, as evaluated by the SBP/Workload slope, is associated with distinct pathophysiological features and impaired functional capacity across the HF spectrum, especially in Stages A-B and in patients with HFpEF. Patients with HRE in these subgroups may be at increased risk of adverse cardiovascular outcomes.
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- 2023
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7. High angular resolution Sunyaev Zel’dovich observations: The case of MISTRAL
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E. S. Battistelli, E. Barbavara, P. de Bernardis, F. Cacciotti, V. Capalbo, E. Carretti, F. Columbro, A. Coppolecchia, A. Cruciani, G. D’Alessandro, M. De Petris, F. Govoni, G. Isopi, L. Lamagna, P. Marongiu, S. Masi, L. Mele, E. Molinari, M. Murgia, A. Navarrini, A. Orlati, A. Paiella, G. Pettinari, F. Piacentini, T. Pisanu, S. Poppi, G. Presta, and F. Radiconi
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- 2023
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8. Polarization Modulator Unit Harness Thermal Design for the Mid- and High-Frequency Telescopes of the LiteBIRD Space Mission
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F. Columbro, P. de Bernardis, and S. Masi
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General Materials Science ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics - Abstract
Polarization modulator units (PMUs) represent a critical and powerful component in CMB polarization experiments to suppress the 1/f noise component and mitigate systematic uncertainties induced by detector gain drifts and beam asymmetries. The LiteBIRD mission (expected launch in the late 2020 s) will be equipped with 3 PMUs, one for each of the 3 telescopes, and aims at detecting the primordial gravitational waves with a sensitivity of $$\delta r δ r < 0.001 . Each PMU is based on a continuously rotating transmissive half-wave plate held by a superconducting magnetic bearing in the 5 K environment. To achieve and monitor the rotation a number of subsystems is needed: clamp and release system and motor coils for the rotation; optical encoder, capacitive, Hall and temperature sensors to monitor its dynamic stability. In this contribution, we present a preliminary thermal design of the harness configuration for the PMUs of the mid- and high- frequency telescopes. The design is based on both the stringent system constraint for the total thermal budget available for the PMUs ($$\lesssim$$ ≲ 4 mW at 5 K) and on the requirements for different subsystem: coils currents (up to 10 mA), optical fibers for encoder readout, 25 MHz bias signal for temperature and levitation monitors.
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- 2022
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9. The impact of ventricular-arterial coupling on aerobic capacity across the heart failure spectrum
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N R Pugliese, A Balletti, S Armenia, N De Biase, F Faita, A Mengozzi, F Paneni, F Ruschitzka, A Virdis, L Ghiadoni, S Taddei, B Williams, F Antonini-Canterin, and S Masi
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Cardiology and Cardiovascular Medicine - Abstract
Background Ventricular-arterial coupling (VAC) can be evaluated as the ratio between arterial stiffness (pulse wave velocity, PWV) and myocardial deformation (global longitudinal strain, GLS). Objectives To evaluate VAC across the spectrum of heart failure (HF). Methods We introduced a Doppler-derived, single-beat technique to estimate aortic arch PWV (aa-PWV) in addition to tonometry-derived carotid-femoral PWV (cf-PWV). We measured PWVs and 3D-GLS in 155 healthy controls, 75 subjects at risk of developing HF (American College of Cardiology/American Heart Association Stage A-B) and 236 patients in HF Stage C with preserved (HFpEF, n=104) or reduced ejection fraction (HFrEF, n=132). We evaluated peak oxygen consumption (VO2) and peripheral extraction (AVO2diff) using combined cardiopulmonary-echocardiography exercise stress. Results aa-PWV was obtainable in all subjects and significantly lower than cf-PWV in all subgroups (p Conclusion Abnormal VAC is directly correlated with greater severity of HF and worse functional capacity. HFpEF shows a worse VAC than HFrEF when expressed by aa-PWV/3D-GLS. Funding Acknowledgement Type of funding sources: None.
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- 2022
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10. Targeting Neurofibromin 2 (NF2) prevents endothelial dysfunction in obesity: a study in mice and humans
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S Costantino, S A Mohammed, E Gorica, S Ambrosini, A Akhmedov, A Virdis, F Ruschitzka, S Masi, and F Paneni
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Cardiology and Cardiovascular Medicine - Abstract
Introduction The mechanisms underlying endothelial dysfunction (ED) in obesity are poorly understood. Neurofibromin 2 (NF2) is a scaffold-like protein involved in cell growth and survival. However, its role in the vascular endothelium is unknown. Purpose To investigate NF2 function in obesity-related ED. Methods Human aortic endothelial cells (HAECs) were exposed to palmitic acid (PA, 200 uM) or vehicle for 48 hours. Gene silencing of NF2 was performed by small interfering RNA (siRNA). Gene and protein expression were assessed by real time PCR and Western blot, respectively. The interaction of NF2 with endothelial proteins was investigated by co-immunoprecipitation. A constitutive active mutant form of NF2 (Ala518) was employed to study the effects of NF2 gain-of-function. To specifically investigate NF2 role in the vascular endothelium, we generated mice with endothelium-specific deletion of NF2 (NF2 ECKO) by crossing NF2flox/flox mice with tamoxifen-inducible endothelial-specific Cre mice [Cdh5(PAC)-CreERT2]. Endothelium-dependent relaxations to acetylcholine (Ach) were assessed in aortas from NF2 ECKO and wild type (WT) littermates, fed a control and a high fat diet (60 kcal% fat) for 20 weeks. NF2 signalling and endothelial function were also assessed in small visceral fat arteries (VFA) isolated from 18 obese and 18 age-matched healthy subjects undergoing bariatric surgery and cholecystectomy, respectively. Gene in silencing of NF2 by siRNA was performed in VFA from obese patients. Results In HAECs, PA promoted NF2 activation by decreasing its phosphorylation at Ser518. Akt and MYPT-1 were responsible for NF2 dephosphorylation. In PA-treated HAECs, NF2 was mainly found in the plasma membrane as compared to other cell fractions. Among different membrane proteins implicated in endothelial homeostasis, NF2 binds and activates Caveolin 1 (Cav-1), a pivotal repressor of endothelial NO synthase (eNOS). NF2 knockdown in PA-treated HAECs prevented eNOS–Cav-1 interaction, thus preserving eNOS activity and NO levels. By contrast, HAECs expressing the constitutive active mutant form of NF2 displayed reduced eNOS activity. In aortas from obese mice, we found that NF2-Cav-1 interaction was responsible for impaired eNOS activity and ED. Cav-1 gene silencing in NF2-overexpressing aortas prevented ED, thus confirming the direct involvement of Cav-1 in NF2-induced ED. Interestingly, Ach-dependent vasorelaxation was preserved in obese NF2 ECKO mice as compared to WT littermates. Moreover, NO bioavailability was preserved in aortas from NF2 ECKO mice. In VFA from obese patients, NF2 was upregulated, and its activity negatively correlated with Ach-dependent vasorelaxation. Of note, NF2 gene silencing in VFA from obese patients rescued ED. Conclusions In human endothelial cells, mice with endothelium-specific deletion of NF2 and VFA from obese patients, we show that NF2 drives ED by repressing Cav-1. Targeting NF2 may prevent ED in obese patients. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Holcim Stiftung
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- 2022
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11. Haemodynamic forces as predictors of cardiac remodelling and outcome in heart failure with reduced ejection fraction treated with sacubitril/valsartan
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I Fabiani, N R Pugliese, V Castiglione, G Pedrizzetti, G Tonti, V Chubuchny, F Becherini, C Taddei, A Gimelli, L Del Punta, A Balletti, S Masi, M Cameli, M Emdin, and A Giannoni
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Cardiology and Cardiovascular Medicine - Abstract
Background Angiotensin receptor-neprilysin inhibitor (ARNI) is a cornerstone of treatment in heart failure (HF) with reduced ejection fraction (HFrEF), but its effectiveness shows interindividual differences. Objectives To evaluate the predictive value of echo-derived hemodynamic forces (HDF), together with other echocardiographic, biohumoral and cardiopulmonary parameters on a) response to ARNI after 6 months; b) adverse cardiovascular events at follow-up. Methods Eighty-nine consecutive HFrEF patients from two HF centers performed clinical evaluation, laboratory analyses, rest echocardiography and cardiopulmonary exercise testing. Response to ARNI at 6 months was considered in patients without HF admissions, death, or urgent heart transplant and with a ≥50% reduction in NT-proBNP levels and/or ≥10% increase in left ventricle ejection fraction. After 6 months, patients were followed up for a composite endpoint of cardiovascular death, HF-related hospitalization and new-onset atrial fibrillation. Results Response to ARNI was documented in 45/89 (51%) of patients. At baseline, responders and non-responders were paired in clinical assessment, conventional echocardiography, functional status and therapy. At multivariate logistic regression analysis, HDF-derived whole cardiac cycle left ventricle strength (wLVS) was the only independent predictor of ARNI response at 6 months (odds ratio 1.36, 95% confidence interval 1.10–1.67; p=0.004). A wLVS ≥3.7% showed a good accuracy in predicting ARNI response (AUC = 0.736, 0.607–0.840; p Conclusions HDF analysis may help predict ARNI response and optimize follow-up and medical/device strategies in patients with HfrEF. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): Fondazione Toscana Gabriele Monasterio, Pisa, Italy
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- 2022
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12. The prognostic impact of BIA-derived fat-free mass index in patients with cancer
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S. Masi, Paolo Pedrazzoli, Emanuele Cereda, Annalisa Turri, Riccardo Caccialanza, Federica Lobascio, Kristina Norman, Sara Cutti, Maja Tank, Silvia Crotti, K. Franz, Andrea Riccardo Filippi, N. Stobäus, Catherine Klersy, and E. Giaquinto
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Male ,0301 basic medicine ,Sarcopenia ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Critical Care and Intensive Care Medicine ,Body Mass Index ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Weight loss ,Germany ,Neoplasms ,Surveys and Questionnaires ,Internal medicine ,Electric Impedance ,medicine ,Humans ,In patient ,Prospective Studies ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Malnutrition ,Nutrition Assessment ,Italy ,Censoring (clinical trials) ,Body Composition ,Quality of Life ,Female ,medicine.symptom ,business ,Bioelectrical impedance analysis ,Body mass index - Abstract
Reduced muscle mass represents one of the top ranked phenotypic criteria for malnutrition proposed by the Global Leadership Initiative on Malnutrition. Although height-indexed fat-free mass (FFMI) thresholds have been proposed as useful surrogate measures of reduced muscle mass, the independent prognostic value of BIA-derived FFMI by bioelectric impedance analysis (BIA) in patients with cancer still needs to be fully explored.Data on body mass index (BMI), 6-month percentage of weight loss (%WL), FFMI by BIA and quality of life (QoL by EORTC Quality of Life Questionnaire [EORTC QLQ-C30]) of Italian and German patients observed prospectively until death or censoring were used (N = 1217). Patients were stratified in 5 risk categories according to a robustly validated scoring system based on BMI and %WL. Low FFMI was defined as follows: men,17 kg/mReduced FFMI was found in 234 patients (19.2%). After a median follow-up of 57 months [25th-75th, 31-60], 620 patients (50.9%) had died. The study detected differences in survival between patients presenting with and without reduced FFMI (14.0 months vs. 45.1 months; P 0.001). The fully-adjusted hazard ratio of mortality for low FFMI was 1.46 [95%CI, 1.18-1.81] (P 0.001). Low FFMI was also independently associated with reduced QoL: fully-adjusted odds ratio, 1.50 [95%CI, 1.00-2.25] (P = 0.050).Reduced FFMI by BIA independently predicted survival and was associated with impaired QoL. Altered body composition should always be considered in all patients with cancer as additional phenotypic criterion of poor prognosis and BIA offers the possibility of multiple, noninvasive bedside assessments.
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- 2021
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13. Tailored Risk Management In Drilling & Completion: Illustrative Case Study Of A Well Campaign
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Fabrizio Zausa, S. Masi, J. Michelez, N. Rossi, and C. Repetto
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Engineering ,Completion (oil and gas wells) ,business.industry ,Drilling ,Operations management ,business ,Risk management - Abstract
Risk Management (RM) is awell recognised approach to addressprojects uncertainties, to provideaccurate CAPEX estimates and tohave proactive responses tounplanned events.However, RM is often presented asa standard and repetitive process,disregard to projects diversechallenges. This acceptance is amain obstacle to its successfulimplementation, because this canlead to over complex risk studies forsimple matter or, on the contrary,scarce results for intricate issues.Drilling & Completion projectspresent a high versatility ofsituations (from a standard onshoreworkover to a very challenging deepoffshore exploratory campaign).Project challenges can be verydifferent: technical (HP/HT, newtechnologies, etc), environmental(sensitive areas, deep offshoreconditions, etc), economic (marketconditions, etc), or strategic(partnership, etc).The natural consequence is thateach project requires an adequateresponse in terms of RM. Actually,RM toolbox encompasses a numberof different studies, such as riskregisters, risk mapping, probabilisticCAPEX/schedule, fault trees, etc.Not all studies should besystematically performed. Thus, theRM approach must be tailored toeach project challenges, in order tobring the highest added value to thedecision makers. eni Drilling, Completion &Production optimization departmenthas built an integrated RM systemthat provides a properly designedworkflow for treating each projectwith a suitable approach accordingto its maturity and other technical,environmental, economic or strategiccriteria.This paper takes advantage of aneni experience on a well campaignand describes how RM approachsupported strategic decisions on theimplementation of technologies(RSS, continuous circulating system,aluminium drill pipe, ceramicprotectors and centralisers) to reducewell operations uncertainties. Thiscase study encompasses thecomplete decision loop, from thecost/benefit analysis of eachtechnology to the measured benefitsfrom the rig operations in terms ofperformance enhancement.Finally, it substantiates the values ofRM in investment decision byaddressing RM in a practical way.This case study will definitely helpto spread a RM culture withinproject management organizations.
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- 2021
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14. Ventricular-arterial coupling derived from proximal aortic stiffness: impact on aerobic capacity across the heart failure spectrum
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NR Pugliese, A Balletti, S Armenia, N De Biase, F Faita, A Mengozzi, F Paneni, F Ruschitzka, A Virdis, L Ghiadoni, S Taddei, B Williams, F Antonini-Canterin, and S Masi
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Epidemiology ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background Ventricular-arterial coupling (VAC) can be evaluated as the ratio between arterial stiffness (pulse wave velocity, PWV) and myocardial deformation (global longitudinal strain, GLS). Objectives To evaluate VAC across the spectrum of heart failure (HF). Methods We introduced a Doppler-derived, single-beat technique to estimate aortic arch PWV (aa-PWV) in addition to tonometry-derived carotid-femoral PWV (cf-PWV). We measured PWVs and GLS in 155 healthy controls, 75 subjects at risk of developing HF (American College of Cardiology/American Heart Association Stage A-B) and 236 patients in HF Stage C with preserved (HFpEF, n=104) or reduced ejection fraction (HFrEF, n=132). We evaluated peak oxygen consumption (VO2) and peripheral extraction (AVO2diff) using combined cardiopulmonary-echocardiography exercise stress. Results aa-PWV was obtainable in all subjects and significantly lower than cf-PWV in all subgroups (p Conclusion Abnormal VAC is directly correlated with greater severity of HF and worse functional capacity. HFpEF shows a worse VAC than HFrEF when expressed by aa-PWV/GLS.
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- 2022
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15. QUBIC VII: The feedhorn-switch system of the technological demonstrator
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F. Cavaliere, A. Mennella, M. Zannoni, P. Battaglia, E. S. Battistelli, D. Burke, G. D’Alessandro, P. de Bernardis, M. De Petris, C. Franceschet, L. Grandsire, J. -Ch. Hamilton, B. Maffei, E. Manzan, S. Marnieros, S. Masi, C. O’Sullivan, A. Passerini, F. Pezzotta, M. Piat, A. Tartari, S. A. Torchinsky, D. Viganò, F. Voisin, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, B. Bélier, A. Baù, S. Banfi, D. Bennett, L. Bergé, J. -Ph. Bernard, M. Bersanelli, M. -A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Buzi, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, M. Gómez Berisso, M. M. Gamboa Lerena, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, E. Pagana, A. Paiella, F. Pajot, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, C. Scóccola, A. Schillaci, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J. -P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, N. Vittorio, F. Wicek, M. Wright, and A. Zullo, Cavaliere, F, Mennella, A, Zannoni, M, Battaglia, P, Battistelli, E, De Bernardis, P, Burke, D, D'Alessandro, G, De Petris, M, Franceschet, C, Grandsire, L, Hamilton, J, Maffei, B, Manzan, B, Marnieros, S, Masi, S, O'Sullivan, C, Passerini, A, Pezzotta, F, Piat, M, Tartari, A, Torchinsky, S, Viganò, D, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Pastoriza, H, Pelosi, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), QUBIC, D’Alessandro, G, de Bernardis, P, Manzan, E, O’Sullivan, C, Pagana, E, Perbost, C, Perciballi, M, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Vittorio, N, Wicek, F, Wright, M, and Zullo, A
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CMBR polarisation ,Physics - Instrumentation and Detectors ,Manchester Cancer Research Centre ,Settore FIS/05 ,ResearchInstitutes_Networks_Beacons/mcrc ,FOS: Physical sciences ,Astronomy and Astrophysics ,Instrumentation and Detectors (physics.ins-det) ,CMBR detectors ,CMBR experiments ,gravitational waves and CMBR polarization ,FIS/05 - ASTRONOMIA E ASTROFISICA ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,CMBR experiment ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,CMBR detector - Abstract
We present the design, manufacturing and performance of the horn-switch system developed for the technological demonstrator of QUBIC (the $Q$\&$U$ Bolometric Interferometer for Cosmology). This system is constituted of 64 back-to-back dual-band (150\,GHz and 220\,GHz) corrugated feed-horns interspersed with mechanical switches used to select desired baselines during the instrument self-calibration. We manufactured the horns in aluminum platelets milled by photo-chemical etching and mechanically tightened with screws. The switches are based on steel blades that open and close the wave-guide between the back-to-back horns and are operated by miniaturized electromagnets. We also show the current development status of the feedhorn-switch system for the QUBIC full instrument, based on an array of 400 horn-switch assemblies., 30 pages, 28 figures. Accepted for submission to JCAP
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- 2022
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16. QUBIC VII: The feedhorn-switch system of the technological demonstrator
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Cavaliere, F, Mennella, A, Zannoni, M, Battaglia, P, Battistelli, E, Burke, D, D’Alessandro, G, de Bernardis, P, De Petris, M, Franceschet, C, Grandsire, L, Hamilton, J, Maffei, B, Manzan, E, Marnieros, S, Masi, S, O’Sullivan, C, Passerini, A, Pezzotta, F, Piat, M, Tartari, A, Torchinsky, S, Viganò, D, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Bélier, B, Baù, A, Banfi, S, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Gómez Berisso, M, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Pagana, E, Paiella, A, Pajot, F, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Vittorio, N, Wicek, F, Wright, M, Zullo, A, F. Cavaliere, A. Mennella, M. Zannoni, P. Battaglia, E. S. Battistelli, D. Burke, G. D’Alessandro, P. de Bernardis, M. De Petris, C. Franceschet, L. Grandsire, J. -Ch. Hamilton, B. Maffei, E. Manzan, S. Marnieros, S. Masi, C. O’Sullivan, A. Passerini, F. Pezzotta, M. Piat, A. Tartari, S. A. Torchinsky, D. Viganò, F. Voisin, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, B. Bélier, A. Baù, S. Banfi, D. Bennett, L. Bergé, J. -Ph. Bernard, M. Bersanelli, M. -A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Buzi, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, M. Gómez Berisso, M. M. Gamboa Lerena, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, E. Pagana, A. Paiella, F. Pajot, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, C. Scóccola, A. Schillaci, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J. -P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, N. Vittorio, F. Wicek, M. Wright, and A. Zullo, Cavaliere, F, Mennella, A, Zannoni, M, Battaglia, P, Battistelli, E, Burke, D, D’Alessandro, G, de Bernardis, P, De Petris, M, Franceschet, C, Grandsire, L, Hamilton, J, Maffei, B, Manzan, E, Marnieros, S, Masi, S, O’Sullivan, C, Passerini, A, Pezzotta, F, Piat, M, Tartari, A, Torchinsky, S, Viganò, D, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Bélier, B, Baù, A, Banfi, S, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Gómez Berisso, M, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Pagana, E, Paiella, A, Pajot, F, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Vittorio, N, Wicek, F, Wright, M, Zullo, A, F. Cavaliere, A. Mennella, M. Zannoni, P. Battaglia, E. S. Battistelli, D. Burke, G. D’Alessandro, P. de Bernardis, M. De Petris, C. Franceschet, L. Grandsire, J. -Ch. Hamilton, B. Maffei, E. Manzan, S. Marnieros, S. Masi, C. O’Sullivan, A. Passerini, F. Pezzotta, M. Piat, A. Tartari, S. A. Torchinsky, D. Viganò, F. Voisin, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, B. Bélier, A. Baù, S. Banfi, D. Bennett, L. Bergé, J. -Ph. Bernard, M. Bersanelli, M. -A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Buzi, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, M. Gómez Berisso, M. M. Gamboa Lerena, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, E. Pagana, A. Paiella, F. Pajot, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, C. Scóccola, A. Schillaci, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J. -P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, N. Vittorio, F. Wicek, M. Wright, and and A. Zullo
- Abstract
We present the design, manufacturing and performance of the horn-switch system developed for the technological demonstrator of QUBIC (the Q&U Bolometric Interferometer for Cosmology). This system consists of 64 back-to-back dual-band (150 GHz and 220 GHz) corrugated feed-horns interposed with mechanical switches used to select desired baselines during the instrument self-calibration. We manufactured the horns in aluminum platelets milled by photo-chemical etching and mechanically tightened with screws. The switches are based on steel blades that open and close the waveguide between the back-to-back horns and are operated by miniaturized electromagnets. The measured electromagnetic performance of the feedhorns agrees with simulations. In particular we obtained a return loss around -20 dB up to 230 GHz and beam patterns in agreement with single-mode simulations down to -30 dB. The switches for this prototype were designed and built for the 150 GHz band. In this frequency range we find return and insertion losses consistent with expectations (< -25 dB and ∼-0.1 dB, respectively) and an isolation larger than 70 dB. In this paper we also show the current development status of the feedhorn-switch system for the QUBIC full instrument, based on an array of 400 horn-switch assemblies.
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- 2022
17. The association between epicardial adipose tissue and prognosis in heart failure with preserved and reduced ejection fraction
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NR Pugliese, N De Biase, M Mazzola, F Paneni, L Del Punta, L Gargani, A Mengozzi, A Virdis, L Nesti, S Taddei, A Flammer, BA Borlaug, F Ruschitzka, and S Masi
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Radiology, Nuclear Medicine and imaging ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background. Recent evidence shows that increased epicardial adipose tissue (EAT) thickness is associated with metabolic syndrome, microvascular dysfunction and enhanced pericardial restraint. Purpose. We measured echocardiography-derived EAT thickness in a population of heart failure (HF) patients with reduced (HFrEF) and preserved (HFpEF) ejection fraction to examine the relationship between EAT and prognosis at clinical follow-up. Methods. We prospectively enrolled 393 consecutive HF outpatients (205 HFrEF, 188 HFpEF) who had been referred to our hospital due to dyspnoea and/or effort intolerance. We performed a resting clinical and biohumoral evaluation, followed by combined cardiopulmonary-echocardiography exercise stress. We considered a composite endpoint of cardiovascular death and HF-related hospitalization during follow-up. Results. Patients with HFpEF displayed greater EAT thickness (median 8 mm, interquartile range [IQR] 4–12 mm) than HFrEF (median 3 mm, IQR 2–6 mm; p Conclusion. EAT accumulation is increased in HFpEF compared to HFrEF and carries different prognostic meanings in the two subsets. In HFpEF, EAT thickening portends adverse outcomes, which may be due to the secretion of pro-inflammatory and pro-atherogenic adipokines and increased mechanical restraint. In HFrEF, EAT thinning is associated with a worse prognosis, probably reflecting a more advanced catabolic state (e.g., cardiac cachexia). Larger studies are needed to determine whether or not EAT has a causal role in influencing progression and survival in the different HF phenotypes. Abstract Figure 1
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18. Evaluation of energy loss in patients with severe primary valvular heart disease before cardiac valve intervention
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NR Pugliese, L Del Punta, G Falcetta, L Besola, N De Biase, M Mazzola, C Giannini, AS Petronio, S Taddei, S Masi, and A Colli
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Radiology, Nuclear Medicine and imaging ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background. Valvular heart disease (VHD) determines non-physiological, inefficient blood flow within the left ventricle, resulting in abnormal vortex formation and energy loss (EL). EL evaluation could provide valuable insights in addition to more common parameters of left ventricle systolic and diastolic dysfunction. Vector flow mapping (VFM) is a novel, non-invasive echocardiographic technique that measures EL through the study of intraventricular flow. Purpose. To assess EL throughout the whole cardiac cycle in patients with severe primary left-sided VHD before cardiac valve intervention. Methods. VFM is based on the continuity equation applied to colour Doppler and speckle tracking echocardiography, acquired from the apical long-axis view. VFM estimates blood flow velocity and vortex characteristics to quantify energy dissipation (i.e., EL) due to blood viscosity in a turbulent flow. EL was calculated frame by frame and averaged over three beats. Results. We enrolled 20 healthy controls (55 ± 19 years old, 65% male) and 73 patients (70 ± 17 years old, 59% male) with severe VHD before cardiac surgery: 30 with primary mitral regurgitation (MR), 8 with mitral stenosis (MS), 15 with aortic regurgitation (AR), 20 with aortic stenosis (AS). All patients had a left ventricle (LV) ejection fraction ≥50% and no wall motion abnormalities. We observed an increased number of vortexes in patients with VHD when compared to controls, especially in mid-diastole (p = 0.003). This is reflected in a significantly higher EL during the whole cardiac cycle in VHD patients than controls (p Conclusions. In addition to standard baseline echocardiography, VFM can quantitatively evaluate the energy dissipation in different subsets of VHD. EL is not uniform during the cardiac cycle, as diastole seems significantly more affected than systole. The assessment of EL after valve intervention is ongoing. VFM could provide further insights into the pathophysiology of heart valve disease and help to evaluate the efficacy of the procedure (repair/replacement) performed. Abstract Figure 1 Abstract Figure 2
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19. The relationship of epicardial adipose tissue with hemodynamics and cardiopulmonary fitness in heart failure with preserved and reduced ejection fraction
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NR Pugliese, N De Biase, M Mazzola, F Paneni, L Del Punta, L Gargani, A Mengozzi, A Virdis, L Nesti, S Taddei, A Flammer, BA Borlaug, F Ruschitzka, and S Masi
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Radiology, Nuclear Medicine and imaging ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background. Recent evidence shows epicardial adipose tissue (EAT) acts as a paracrine organ and may directly alter myocardial function by exerting mechanical compression. Purpose. We evaluated EAT thickness through transthoracic echocardiography and investigated its relationship with cardiopulmonary fitness and cardiovascular haemodynamics at rest and during exercise in a population of heart failure (HF) patients with reduced (HFrEF) and preserved (HFpEF) ejection fraction. Methods. We prospectively enrolled 393 consecutive HF outpatients (205 HFrEF, 188 HFpEF) who had been referred to our hospital due to dyspnoea and/or effort intolerance, together with 44 healthy controls. We performed a resting state-of-the-art echocardiographic evaluation, followed by combined cardiopulmonary-echocardiography exercise stress. Results. EAT thickness was higher in HFpEF (median 8 mm, interquartile range [IQR] 4–12 mm) and progressively reduced in controls (median 5 mm, IQR 3–7 mm; p As there are no definite cut-off values to define increased EAT, patients were divided based on the median EAT value (5 mm) of the overall population. Thinner EAT (≤5 mm) was associated with worse LV systolic dysfunction (peak average S’) and remodeling (3D LV mass index) in HFrEF. In HFpEF, on the other hand, increased EAT (>5 mm) was related to worse right ventricular systolic dysfunction (3D right ventricular ejection fraction) and more severe left atrio-ventricular (left atrium reservoir strain/left ventricle global longitudinal strain) and right ventriculo-arterial (tricuspid annular plane systolic excursion/systolic pulmonary artery pressure) coupling (Figure 2). Conclusion. In HFpEF, increased EAT thickness is associated with a worse hemodynamic profile and functional capacity. Conversely, in HFrEF, EAT thinning portends more advanced LV dysfunction and impaired cardiopulmonary fitness. Abstract Figure 1 Abstract Figure 2
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- 2022
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20. MISTRAL and its KIDs
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A. Paiella, P. de Bernardis, F. Cacciotti, A. Coppolecchia, S. Masi, E. Barbavara, E. S. Battistelli, E. Carretti, F. Columbro, A. Cruciani, G. D’Alessandro, M. De Petris, F. Govoni, G. Isopi, L. Lamagna, P. Marongiu, L. Mele, E. Molinari, M. Murgia, A. Navarrini, A. Orlati, G. Pettinari, F. Piacentini, T. Pisanu, S. Poppi, G. Presta, and F. Radiconi
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General Materials Science ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics - Abstract
The MIllimetric Sardinia radio Telescope Receiver based on Array of Lumped elements KIDs, MISTRAL, is a cryogenic W-band (77–103 GH) LEKID camera which will be integrated at the Gregorian focus of the 64 m aperture Sardinia Radio Telescope, in Italy, in Autumn 2022. This instrument, thanks to its high angular resolution ($$\sim 13~{\mathrm{arcsec}}$$ ∼ 13 arcsec ) and the wide instantaneous field of view ($$\sim 4~{\mathrm{arcmin}}$$ ∼ 4 arcmin ), will allow continuum surveys of the mm-wave sky with a variety of scientific targets, spanning from extragalactic astrophysics to solar system science. In this contribution, we will describe the design of the MISTRAL camera, with a particular focus on the optimisation and test of a prototype of the focal plane.
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- 2022
21. Optical Characterization of OMT-Coupled TES Bolometers for LiteBIRD
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J. Hubmayr, P. A. R. Ade, A. Adler, E. Allys, D. Alonso, K. Arnold, D. Auguste, J. Aumont, R. Aurlien, J. E. Austermann, S. Azzoni, C. Baccigalupi, A. J. Banday, R. Banerji, R. B. Barreiro, N. Bartolo, S. Basak, E. Battistelli, L. Bautista, J. A. Beall, D. Beck, S. Beckman, K. Benabed, J. Bermejo-Ballesteros, M. Bersanelli, J. Bonis, J. Borrill, F. Bouchet, F. Boulanger, S. Bounissou, M. Brilenkov, M. L. Brown, M. Bucher, E. Calabrese, M. Calvo, P. Campeti, A. Carones, F. J. Casas, A. Catalano, A. Challinor, V. Chan, K. Cheung, Y. Chinone, C. Chiocchetta, S. E. Clark, L. Clermont, S. Clesse, J. Cliche, F. Columbro, J. A. Connors, A. Coppolecchia, W. Coulton, J. Cubas, A. Cukierman, D. Curtis, F. Cuttaia, G. D’Alessandro, K. Dachlythra, P. de Bernardis, T. de Haan, E. de la Hoz, M. De Petris, S. Della Torre, J. J. Daz Garca, C. Dickinson, P. Diego-Palazuelos, M. Dobbs, T. Dotani, D. Douillet, E. Doumayrou, L. Duband, A. Ducout, S. M. Duff, J. M. Duval, K. Ebisawa, T. Elleflot, H. K. Eriksen, J. Errard, T. Essinger-Hileman, S. Farrens, F. Finelli, R. Flauger, K. Fleury-Frenette, C. Franceschet, U. Fuskeland, L. Galli, S. Galli, M. Galloway, K. Ganga, J. R. Gao, R. T. Genova-Santos, M. Georges, M. Gerbino, M. Gervasi, T. Ghigna, S. Giardiello, E. Gjerlw, R. Gonzlez Gonzles, M. L. Gradziel, J. Grain, L. Grandsire, F. Grupp, A. Gruppuso, J. E. Gudmundsson, N. W. Halverson, J. Hamilton, P. Hargrave, T. Hasebe, M. Hasegawa, M. Hattori, M. Hazumi, S. Henrot-Versill, B. Hensley, D. Herman, D. Herranz, G. C. Hilton, E. Hivon, R. A. Hlozek, D. Hoang, A. L. Hornsby, Y. Hoshino, K. Ichiki, T. Iida, T. Ikemoto, H. Imada, K. Ishimura, H. Ishino, G. Jaehnig, M. Jones, T. Kaga, S. Kashima, N. Katayama, A. Kato, T. Kawasaki, R. Keskitalo, C. Kintziger, T. Kisner, Y. Kobayashi, N. Kogiso, A. Kogut, K. Kohri, E. Komatsu, K. Komatsu, K. Konishi, N. Krachmalnicoff, I. Kreykenbohm, C. L. Kuo, A. Kushino, L. Lamagna, J. V. Lanen, G. Laquaniello, M. Lattanzi, A. T. Lee, C. Leloup, F. Levrier, E. Linder, M. J. Link, A. I. Lonappan, T. Louis, G. Luzzi, J. Macias-Perez, T. Maciaszek, B. Maffei, D. Maino, M. Maki, S. Mandelli, M. Maris, B. Marquet, E. Martnez-Gonzlez, F. A. Martire, S. Masi, M. Massa, M. Masuzawa, S. Matarrese, F. T. Matsuda, T. Matsumura, L. Mele, A. Mennella, M. Migliaccio, Y. Minami, K. Mitsuda, A. Moggi, M. Monelli, A. Monfardini, J. Montgomery, L. Montier, G. Morgante, B. Mot, Y. Murata, J. A. Murphy, M. Nagai, Y. Nagano, T. Nagasaki, R. Nagata, S. Nakamura, R. Nakano, T. Namikawa, F. Nati, P. Natoli, S. Nerval, N. Neto Godry Farias, T. Nishibori, H. Nishino, F. Noviello, G. C. O’Neil, C. O’Sullivan, K. Odagiri, H. Ochi, H. Ogawa, S. Oguri, H. Ohsaki, I. S. Ohta, N. Okada, L. Pagano, A. Paiella, D. Paoletti, G. Pascual Cisneros, A. Passerini, G. Patanchon, V. Pelgrim, J. Peloton, V. Pettorino, F. Piacentini, M. Piat, G. Piccirilli, F. Pinsard, G. Pisano, J. Plesseria, G. Polenta, D. Poletti, T. Prouv, G. Puglisi, D. Rambaud, C. Raum, S. Realini, M. Reinecke, C. D. Reintsema, M. Remazeilles, A. Ritacco, P. Rosier, G. Roudil, J. Rubino-Martin, M. Russell, H. Sakurai, Y. Sakurai, M. Sandri, M. Sasaki, G. Savini, D. Scott, J. Seibert, Y. Sekimoto, B. Sherwin, K. Shinozaki, M. Shiraishi, P. Shirron, A. Shitvov, G. Signorelli, G. Smecher, F. Spinella, J. Starck, S. Stever, R. Stompor, R. Sudiwala, S. Sugiyama, R. Sullivan, A. Suzuki, J. Suzuki, T. Suzuki, T. L. Svalheim, E. Switzer, R. Takaku, H. Takakura, S. Takakura, Y. Takase, Y. Takeda, A. Tartari, D. Tavagnacco, A. Taylor, E. Taylor, Y. Terao, L. Terenzi, J. Thermeau, H. Thommesen, K. L. Thompson, B. Thorne, T. Toda, M. Tomasi, M. Tominaga, N. Trappe, M. Tristram, M. Tsuji, M. Tsujimoto, C. Tucker, R. Ueki, J. N. Ullom, K. Umemori, L. Vacher, J. Van Lanen, G. Vermeulen, P. Vielva, F. Villa, M. R. Vissers, N. Vittorio, B. Wandelt, W. Wang, I. K. Wehus, J. Weller, B. Westbrook, G. Weymann-Despres, J. Wilms, B. Winter, E. J. Wollack, N. Y. Yamasaki, T. Yoshida, J. Yumoto, K. Watanuki, A. Zacchei, M. Zannoni, A. Zonca, Hubmayr, J, Ade, P, Adler, A, Allys, E, Alonso, D, Arnold, K, Auguste, D, Aumont, J, Aurlien, R, Austermann, J, Azzoni, S, Baccigalupi, C, Banday, A, Banerji, R, Barreiro, R, Bartolo, N, Basak, S, Battistelli, E, Bautista, L, Beall, J, Beck, D, Beckman, S, Benabed, K, Bermejo-Ballesteros, J, Bersanelli, M, Bonis, J, Borrill, J, Bouchet, F, Boulanger, F, Bounissou, S, Brilenkov, M, Brown, M, Bucher, M, Calabrese, E, Calvo, M, Campeti, P, Carones, A, Casas, F, Catalano, A, Challinor, A, Chan, V, Cheung, K, Chinone, Y, Chiocchetta, C, Clark, S, Clermont, L, Clesse, S, Cliche, J, Columbro, F, Connors, J, Coppolecchia, A, Coulton, W, Cubas, J, Cukierman, A, Curtis, D, Cuttaia, F, D’Alessandro, G, Dachlythra, K, de Bernardis, P, de Haan, T, de la Hoz, E, De Petris, M, Della Torre, S, Daz Garca, J, Dickinson, C, Diego-Palazuelos, P, Dobbs, M, Dotani, T, Douillet, D, Doumayrou, E, Duband, L, Ducout, A, Duff, S, Duval, J, Ebisawa, K, Elleflot, T, Eriksen, H, Errard, J, Essinger-Hileman, T, Farrens, S, Finelli, F, Flauger, R, Fleury-Frenette, K, Franceschet, C, Fuskeland, U, Galli, L, Galli, S, Galloway, M, Ganga, K, Gao, J, Genova-Santos, R, Georges, M, Gerbino, M, Gervasi, M, Ghigna, T, Giardiello, S, Gjerlw, E, Gonzles, R, Gradziel, M, Grain, J, Grandsire, L, Grupp, F, Gruppuso, A, Gudmundsson, J, Halverson, N, Hamilton, J, Hargrave, P, Hasebe, T, Hasegawa, M, Hattori, M, Hazumi, M, Henrot-Versill, S, Hensley, B, Herman, D, Herranz, D, Hilton, G, Hivon, E, Hlozek, R, Hoang, D, Hornsby, A, Hoshino, Y, Ichiki, K, Iida, T, Ikemoto, T, Imada, H, Ishimura, K, Ishino, H, Jaehnig, G, Jones, M, Kaga, T, Kashima, S, Katayama, N, Kato, A, Kawasaki, T, Keskitalo, R, Kintziger, C, Kisner, T, Kobayashi, Y, Kogiso, N, Kogut, A, Kohri, K, Komatsu, E, Komatsu, K, Konishi, K, Krachmalnicoff, N, Kreykenbohm, I, Kuo, C, Kushino, A, Lamagna, L, Lanen, J, Laquaniello, G, Lattanzi, M, Lee, A, Leloup, C, Levrier, F, Linder, E, Link, M, Lonappan, A, Louis, T, Luzzi, G, Macias-Perez, J, Maciaszek, T, Maffei, B, Maino, D, Maki, M, Mandelli, S, Maris, M, Marquet, B, Martnez-Gonzlez, E, Martire, F, Masi, S, Massa, M, Masuzawa, M, Matarrese, S, Matsuda, F, Matsumura, T, Mele, L, Mennella, A, Migliaccio, M, Minami, Y, Mitsuda, K, Moggi, A, Monelli, M, Monfardini, A, Montgomery, J, Montier, L, Morgante, G, Mot, B, Murata, Y, Murphy, J, Nagai, M, Nagano, Y, Nagasaki, T, Nagata, R, Nakamura, S, Nakano, R, Namikawa, T, Nati, F, Natoli, P, Nerval, S, Neto Godry Farias, N, Nishibori, T, Nishino, H, Noviello, F, O’Neil, G, O’Sullivan, C, Odagiri, K, Ochi, H, Ogawa, H, Oguri, S, Ohsaki, H, Ohta, I, Okada, N, Pagano, L, Paiella, A, Paoletti, D, Pascual Cisneros, G, Passerini, A, Patanchon, G, Pelgrim, V, Peloton, J, Pettorino, V, Piacentini, F, Piat, M, Piccirilli, G, Pinsard, F, Pisano, G, Plesseria, J, Polenta, G, Poletti, D, Prouv, T, Puglisi, G, Rambaud, D, Raum, C, Realini, S, Reinecke, M, Reintsema, C, Remazeilles, M, Ritacco, A, Rosier, P, Roudil, G, Rubino-Martin, J, Russell, M, Sakurai, H, Sakurai, Y, Sandri, M, Sasaki, M, Savini, G, Scott, D, Seibert, J, Sekimoto, Y, Sherwin, B, Shinozaki, K, Shiraishi, M, Shirron, P, Shitvov, A, Signorelli, G, Smecher, G, Spinella, F, Starck, J, Stever, S, Stompor, R, Sudiwala, R, Sugiyama, S, Sullivan, R, Suzuki, A, Suzuki, J, Suzuki, T, Svalheim, T, Switzer, E, Takaku, R, Takakura, H, Takakura, S, Takase, Y, Takeda, Y, Tartari, A, Tavagnacco, D, Taylor, A, Taylor, E, Terao, Y, Terenzi, L, Thermeau, J, Thommesen, H, Thompson, K, Thorne, B, Toda, T, Tomasi, M, Tominaga, M, Trappe, N, Tristram, M, Tsuji, M, Tsujimoto, M, Tucker, C, Ueki, R, Ullom, J, Umemori, K, Vacher, L, Van Lanen, J, Vermeulen, G, Vielva, P, Villa, F, Vissers, M, Vittorio, N, Wandelt, B, Wang, W, Wehus, I, Weller, J, Westbrook, B, Weymann-Despres, G, Wilms, J, Winter, B, Wollack, E, Yamasaki, N, Yoshida, T, Yumoto, J, Watanuki, K, Zacchei, A, Zannoni, M, Zonca, A, and National Aeronautics and Space Administration (US)
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CMB ,TES ,OMT ,Low temperature detector ,Bolometer ,FIS/05 - ASTRONOMIA E ASTROFISICA ,Settore FIS/05 - Astronomia e Astrofisica ,General Materials Science ,Condensed Matter Physics ,CMB, TES, OMT, Low temperature detector, Bolometer ,Atomic and Molecular Physics, and Optics - Abstract
et al., Feedhorn- and orthomode transducer- (OMT) coupled transition edge sensor (TES) bolometers have been designed and micro-fabricated to meet the optical specifications of the LiteBIRD high frequency telescope (HFT) focal plane. We discuss the design and optical characterization of two LiteBIRD HFT detector types: dual-polarization, dual-frequency-band pixels with 195/280 GHz and 235/337 GHz band centers. Results show well-matched passbands between orthogonal polarization channels and frequency centers within 3% of the design values. The optical efficiency of each frequency channel is conservatively reported to be within the range 0.64−0.72, determined from the response to a cryogenic, temperature-controlled thermal source. These values are in good agreement with expectations and either exceed or are within 10% of the values used in the LiteBIRD sensitivity forecast. Lastly, we report a measurement of loss in Nb/SiNx/Nb microstrip at 100 mK and over the frequency range 200–350 GHz, which is comparable to values previously reported in the literature., This work is supported by NASA under grant no. 80NSSC18K0132.
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- 2022
22. A testbed for modeling validation and characterization of quasi-optical elements in microwave receivers
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L. Lamagna, M. Basilicata, A. Occhiuzzi, F. Columbro, A. Coppolecchia, G. D’Alessandro, P. de Bernardis, S. Masi, L. Mele, A. Paiella, and G. Pisano
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cosmic microwave background ,quasi-optical systems ,B–modes ,General Materials Science ,Fourier transform spectroscopy ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics - Abstract
We describe the setup for the broadband millimeter/submillimeter characterization of the quasi-optical elements and the dielectric materials commonly used in microwave receivers operated in microwave astronomy. The setup is made of a large aperture (100 mm) Fourier transform spectrometer coupled to a transition edge superconducting detector. The system has been assembled and characterized in different configurations and operation modes for the acquisition of interferograms from various kinds of samples. After the initial test runs, the configuration is now being updated to ensure a broader range of measurements, including reflectance and scattering. We plan to first use this testbed for the characterization of the dielectric materials used in the LSPE/SWIPE experiment, devoted to the study the polarization of the Cosmic Microwave Background.
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- 2022
23. QUBIC Experiment Toward the First Light
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G. D’Alessandro, E. S. Battistelli, P. de Bernardis, M. De Petris, M. M. Gamboa Lerena, L. Grandsire, J.-Ch. Hamilton, S. Marnieros, S. Masi, A. Mennella, L. Mousset, C. O’Sullivan, M. Piat, A. Tartari, S. A. Torchinsky, F. Voisin, M. Zannoni, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, S. Banfi, A. Baù, B. Bélier, D. Bennett, L. Bergé, J.-Ph. Bernard, M. Bersanelli, M.-A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Burke, D. Buzi, F. Cavaliere, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, C. Franceschet, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. Gómez Berisso, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, B. Maffei, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, A. Paiella, F. Pajot, A. Passerini, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Pezzotta, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, G. Presta, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, A. Schillaci, C. G. Scóccola, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J.-P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, D. Viganò, N. Vittorio, F. Wicek, M. Wright, A. Zullo, D’Alessandro, G, Battistelli, E, de Bernardis, P, De Petris, M, Gamboa Lerena, M, Grandsire, L, Hamilton, J, Marnieros, S, Masi, S, Mennella, A, Mousset, L, O’Sullivan, C, Piat, M, Tartari, A, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Presta, G, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Wicek, F, Wright, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), and QUBIC
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Instruments ,mm-wave ,Applications ,astrophysics and cosmology ,Settore FIS/05 ,Applications: astrophysics and cosmology ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,FIS/05 - ASTRONOMIA E ASTROFISICA ,FIS/01 - FISICA SPERIMENTALE ,Settore FIS/05 - Astronomia e Astrofisica ,Instruments: mm-wave ,Instruments: mm-wave · Applications: astrophysics and cosmology ,General Materials Science ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] - Abstract
International audience; The Q & U Bolometric Interferometer for Cosmology (QUBIC) is a cosmology experiment that aims to measure the B-mode polarization of the cosmic microwave background (CMB). Measurements of the primordial B-mode pattern of the CMB polarization are in fact among the most exciting goals in cosmology as it would allow testing of the inflationary paradigm. Many experiments are attempting to measure the B-modes, from the ground and the stratosphere, using imaging Stokes polarimeters. The QUBIC collaboration developed an innovative concept to measure CMB polarization using bolometric interferometry. This approach mixes the high sensitivity of bolometric detectors with the accurate control of systematics due to the interferometric layout of the instrument. We present the calibration results for the Technological Demonstrator, before its commissioning in the Argentinian observing site and preparation for first light.
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- 2022
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24. The COSmic Monopole Observer (COSMO)
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S. Masi, E. Battistelli, P. de Bernardis, F. Columbro, A. Coppolecchia, G. D’Alessandro, M. De Petris, L. Lamagna, E. Marchitelli, L. Mele, A. Paiella, F. Piacentini, G. Pisano, M. Bersanelli, C. Franceschet, E. Manzan, D. Mennella, S. Realini, S. Cibella, F. Martini, G. Pettinari, G. Coppi, M. Gervasi, A. Limonta, M. Zannoni, L. Piccirillo, and C. Tucker
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Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) - Abstract
The COSmic Monopole Observer (COSMO) is an experiment to measure low-level spectral distortions in the isotropic component of the Cosmic Microwave Background (CMB). Deviations from a pure blackbody spectrum are expected at low level ($, Comment: To be published on the proceedings of the 16th Marcel Grossmann Meeting on Recent Developments in Theoretical and Experimental General Relativity, Astrophysics and Relativistic Field Theories (MG16) - 5-9 July 2021. Online Conference, Italy - http://www.icra.it/mg/mg16/
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- 2021
25. Joint Analysis of BICEP2/Keck ArrayandPlanckData
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P. A. R. Ade, N. Aghanim, Z. Ahmed, R. W. Aikin, K. D. Alexander, M. Arnaud, J. Aumont, C. Baccigalupi, A. J. Banday, D. Barkats, R. B. Barreiro, J. G. Bartlett, N. Bartolo, E. Battaner, K. Benabed, A. Benoît, A. Benoit-Lévy, S. J. Benton, J.-P. Bernard, M. Bersanelli, P. Bielewicz, C. A. Bischoff, J. J. Bock, A. Bonaldi, L. Bonavera, J. R. Bond, J. Borrill, F. R. Bouchet, F. Boulanger, J. A. Brevik, M. Bucher, I. Buder, E. Bullock, C. Burigana, R. C. Butler, V. Buza, E. Calabrese, J.-F. Cardoso, A. Catalano, A. Challinor, R.-R. Chary, H. C. Chiang, P. R. Christensen, L. P. L. Colombo, C. Combet, J. Connors, F. Couchot, A. Coulais, B. P. Crill, A. Curto, F. Cuttaia, L. Danese, R. D. Davies, R. J. Davis, P. de Bernardis, A. de Rosa, G. de Zotti, J. Delabrouille, J.-M. Delouis, F.-X. Désert, C. Dickinson, J. M. Diego, H. Dole, S. Donzelli, O. Doré, M. Douspis, C. D. Dowell, L. Duband, A. Ducout, J. Dunkley, X. Dupac, C. Dvorkin, G. Efstathiou, F. Elsner, T. A. Enßlin, H. K. Eriksen, E. Falgarone, J. P. Filippini, F. Finelli, S. Fliescher, O. Forni, M. Frailis, A. A. Fraisse, E. Franceschi, A. Frejsel, S. Galeotta, S. Galli, K. Ganga, T. Ghosh, M. Giard, E. Gjerløw, S. R. Golwala, J. González-Nuevo, K. M. Górski, S. Gratton, A. Gregorio, A. Gruppuso, J. E. Gudmundsson, M. Halpern, F. K. Hansen, D. Hanson, D. L. Harrison, M. Hasselfield, G. Helou, S. Henrot-Versillé, D. Herranz, S. R. Hildebrandt, G. C. Hilton, E. Hivon, M. Hobson, W. A. Holmes, W. Hovest, V. V. Hristov, K. M. Huffenberger, H. Hui, G. Hurier, K. D. Irwin, A. H. Jaffe, T. R. Jaffe, J. Jewell, W. C. Jones, M. Juvela, A. Karakci, K. S. Karkare, J. P. Kaufman, B. G. Keating, S. Kefeli, E. Keihänen, S. A. Kernasovskiy, R. Keskitalo, T. S. Kisner, R. Kneissl, J. Knoche, L. Knox, J. M. Kovac, N. Krachmalnicoff, M. Kunz, C. L. Kuo, H. Kurki-Suonio, G. Lagache, A. Lähteenmäki, J.-M. Lamarre, A. Lasenby, M. Lattanzi, C. R. Lawrence, E. M. Leitch, R. Leonardi, F. Levrier, A. Lewis, M. Liguori, P. B. Lilje, M. Linden-Vørnle, M. López-Caniego, P. M. Lubin, M. Lueker, J. F. Macías-Pérez, B. Maffei, D. Maino, N. Mandolesi, A. Mangilli, M. Maris, P. G. Martin, E. Martínez-González, S. Masi, P. Mason, S. Matarrese, K. G. Megerian, P. R. Meinhold, A. Melchiorri, L. Mendes, A. Mennella, M. Migliaccio, S. Mitra, M.-A. Miville-Deschênes, A. Moneti, L. Montier, G. Morgante, D. Mortlock, A. Moss, D. Munshi, J. A. Murphy, P. Naselsky, F. Nati, P. Natoli, C. B. Netterfield, H. T. Nguyen, H. U. Nørgaard-Nielsen, F. Noviello, D. Novikov, I. Novikov, R. O’Brient, R. W. Ogburn, A. Orlando, L. Pagano, F. Pajot, R. Paladini, D. Paoletti, B. Partridge, F. Pasian, G. Patanchon, T. J. Pearson, O. Perdereau, L. Perotto, V. Pettorino, F. Piacentini, M. Piat, D. Pietrobon, S. Plaszczynski, E. Pointecouteau, G. Polenta, N. Ponthieu, G. W. Pratt, S. Prunet, C. Pryke, J.-L. Puget, J. P. Rachen, W. T. Reach, R. Rebolo, M. Reinecke, M. Remazeilles, C. Renault, A. Renzi, S. Richter, I. Ristorcelli, G. Rocha, M. Rossetti, G. Roudier, M. Rowan-Robinson, J. A. Rubiño-Martín, B. Rusholme, M. Sandri, D. Santos, M. Savelainen, G. Savini, R. Schwarz, D. Scott, M. D. Seiffert, C. D. Sheehy, L. D. Spencer, Z. K. Staniszewski, V. Stolyarov, R. Sudiwala, R. Sunyaev, D. Sutton, A.-S. Suur-Uski, J.-F. Sygnet, J. A. Tauber, G. P. Teply, L. Terenzi, K. L. Thompson, L. Toffolatti, J. E. Tolan, M. Tomasi, M. Tristram, M. Tucci, A. D. Turner, L. Valenziano, J. Valiviita, B. Van Tent, L. Vibert, P. Vielva, A. G. Vieregg, F. Villa, L. A. Wade, B. D. Wandelt, R. Watson, A. C. Weber, I. K. Wehus, M. White, S. D. M. White, J. Willmert, C. L. Wong, K. W. Yoon, D. Yvon, A. Zacchei, and A. Zonca
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- 2015
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26. Early caloric deficit is associated with a higher risk of death in invasive ventilated COVID-19 patients
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Monica Savioli, Catherine Klersy, Alberto Zanella, Francesco Mojoli, Fabio Sciutti, Giacomo Grasselli, S. Masi, Andrea Pellegrini, Riccardo Caccialanza, Amedeo Guzzardella, Emanuele Cereda, Mirko Belliato, Silvia Mongodi, and Silvia Crotti
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0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Critical Illness ,Population ,030209 endocrinology & metabolism ,Critical Care and Intensive Care Medicine ,Enteral administration ,Early caloric deficit ,03 medical and health sciences ,Mechanical ventilation ,0302 clinical medicine ,Internal medicine ,Intensive care ,Medicine ,Humans ,Prospective Studies ,Obesity ,Mortality ,Nutritional support ,Prospective cohort study ,education ,education.field_of_study ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Coronavirus disease 2019 ,business.industry ,Confounding ,COVID-19 ,medicine.disease ,Respiration, Artificial ,Intensive Care Units ,business ,Body mass index - Abstract
BACKGROUND & AIMS: The aim of this study was to evaluate the nutritional support management in mechanically ventilated coronavirus disease 2019 (COVID-19) patients and explore the association between early caloric deficit and mortality, taking possible confounders (i.e. obesity) into consideration. METHODS: This was a prospective study carried out during the first pandemic wave in the intensive care units (ICUs) of two referral University Hospitals in Lombardy, Italy. Two hundred twenty-two consecutive mechanically ventilated COVID-19 patients were evaluated during the ICU stay. In addition to major demographic and clinical data, we recorded information on the route and amount of nutritional support provided on a daily basis. RESULTS: Among patients still in the ICUs and alive on day 4 (N = 198), 129 (65.2%) and 72 (36.4%) reached a satisfactory caloric and protein intake, respectively, mainly by enteral route. In multivariable analysis, a satisfactory caloric intake on day 4 was associated with lower mortality (HR = 0.46 [95%CI, 0.42-0.50], P
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- 2021
27. Quality of life and psychopathology in candidates to bariatric surgery: relationship with BMI class
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S. Masi, Antonios Dakanalis, Catherine Klersy, Riccardo Caccialanza, C. Cavallotto, Valentina Martinelli, Andrea Peri, Andrea Pietrabissa, Eugenia Pellegrino, Pierluigi Politi, A. Cappa, N. Mineo, Federica Lobascio, Silvia Cappello, Chiara Muggia, F. Bruno, Matteo Chiappedi, Maria Zugnoni, Martinelli, V, Cappa, A, Zugnoni, M, Cappello, S, Masi, S, Klersy, C, Pellegrino, E, Muggia, C, Cavallotto, C, Politi, P, Bruno, F, Mineo, N, Peri, A, Lobascio, F, Chiappedi, M, Dakanalis, A, Pietrabissa, A, and Caccialanza, R
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Quality of life ,050103 clinical psychology ,medicine.medical_specialty ,030309 nutrition & dietetics ,Population ,03 medical and health sciences ,Binge-eating disorder ,Binge eating disorder ,medicine ,Humans ,0501 psychology and cognitive sciences ,Obesity cla ,education ,Body mass index ,Bariatric surgery ,0303 health sciences ,education.field_of_study ,business.industry ,Mental Disorders ,05 social sciences ,medicine.disease ,humanities ,Obesity, Morbid ,Surgery ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Psychiatric interview ,Binge Eating Scale ,business ,Psychosocial ,Psychopathology - Abstract
Purpose: This cross-sectional study aimed at comparing the quality of life (Qol), the prevalence of psychiatric diagnosis and pharmacological treatment in 104 candidates to bariatric surgery according to the degree of obesity (class 2 vs. class ≥ 3 obesity). Methods: All surgical candidates underwent a detailed psychiatric interview based on DSM-5 criteria, including sociodemographic, clinical, psychological and psychiatric data. Participants completed the Binge Eating Scale (BES) and the 12-Item Short Form Health Survey (SF-12). Results: Overall, bariatric candidates reported a significant impairment in the physical (PCS 38.8 [95% CI 36.2–41.5]) and mental (MCS 42.2 [95% CI 40.4–43.9]) components of Qol compared to population norms (p < 0.001 for both). Subjects with class 2 obesity scored significantly lower in the MCS compared to those with class 3 (38.7 (8.1) vs. 43.6 (8.4), p = 0.008). No other statistically significant differences were found between the two groups in terms of sociodemographic and clinical variables. Conclusion: These data support the usefulness of Qol assessment in bariatric candidates as a sensible screening parameter, especially in patients with lower BMI, in whom MCS could identify the need for early psychosocial intervention. Level of evidence: Level III,case-control analyticstudy.
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- 2021
28. Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital
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Francesca Mariani, Emanuele Cereda, Catherine Klersy, Mirko Belliato, Stefano Perlini, Ludovico De Stefano, Jacopo Mambella, S. Masi, Federica Lobascio, Carlomaurizio Montecucco, Laura Bogliolo, Valeria Musella, Francesco Di Terlizzi, Riccardo Caccialanza, Chiara Muggia, Gabriele Croce, Antonio Di Sabatino, Silvia Crotti, Angelo Corsico, Chiara Barteselli, Alessandra Ferrari, Raffaele Bruno, and Serena Ludovisi
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0301 basic medicine ,Male ,medicine.medical_specialty ,Referral ,Coronavirus disease 2019 (COVID-19) ,Short Communication ,030209 endocrinology & metabolism ,Critical Care and Intensive Care Medicine ,Tertiary referral hospital ,Severity of Illness Index ,vitamin D deficiency ,Cohort Studies ,Tertiary Care Centers ,03 medical and health sciences ,coronavirus disease 2019 ,0302 clinical medicine ,Disease severity ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,Hospital Mortality ,Prospective Studies ,vitamin D 25OH ,Vitamin D ,Aged ,Aged, 80 and over ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,SARS-CoV-2 ,hospitalized patients ,COVID-19 ,Middle Aged ,medicine.disease ,Vitamin D Deficiency ,mortality ,Italy ,Referral center ,disease severity ,Female ,business ,Biomarkers ,Cohort study - Abstract
Background & Aims Great interest has been raised by the possible protective role of vitamin D in coronavirus disease 2019 (COVID-19), but objective data on 25(OH)vitamin D deficiency in hospitalized COVID-19 patients are not conclusive. The aim of this study was to determine the prevalence of 25(OH)vitamin D deficiency in COVID-19 patients admitted to an Italian referral hospital and explore its association with clinical outcomes and the markers of disease severity. Methods In this single-center cohort study, 129 consecutive adult COVID-19 patients hospitalized in an Italian referral center were enrolled from March to April 2020. 25(OH)Vitamin D serum levels were assessed 48 hours since hospital admission and categorized into: normal (≥30 ng/mL), insufficient (
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- 2020
29. Providing nutritional care to cancer patients during the COVID-19 pandemic: an Italian perspective
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S. Masi, Riccardo Caccialanza, Marco Inglardi, Valeria Borioli, Silvia Crotti, Emanuele Cereda, Gianpiero Rizzo, Silvia Brugnatelli, Teresa Monaco, Silvia Cappello, Paolo Pedrazzoli, Giuseppina Grugnetti, Antonio Triarico, Federica Lobascio, Simona Secondino, and Alba Muzzi
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medicine.medical_specialty ,Pneumonia, Viral ,Nutritional Status ,Clinical nutrition ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Quality of life (healthcare) ,Neoplasms ,Health care ,Pandemic ,medicine ,Humans ,030212 general & internal medicine ,Intensive care medicine ,Nutritional care ,Pandemics ,Cancer ,business.industry ,Nutritional Support ,SARS-CoV-2 ,Nursing research ,Malnutrition ,COVID-19 ,Coronavirus disease (COVID-19) ,medicine.disease ,Community hospital ,Hospitals ,Italy ,Oncology ,030220 oncology & carcinogenesis ,Quality of Life ,Commentary ,business ,Coronavirus Infections ,Delivery of Health Care - Abstract
The COVID-19 outbreak has drastically changed practices inside hospitals, which include oncology routines. In oncology, malnutrition was and certainly still is a frequent problem associated with an increase in treatment-related toxicity, a reduced response to cancer treatment, an impaired quality of life, and a worse overall prognosis. Even in this situation of healthcare crisis, nutritional support in cancer care is an essential element. During the current COVID-19 pandemic, there is a concrete high risk to see a dramatic worsening of cancer patients' nutritional status, who are left without adequate clinical and nutritional support. The consequences are already reasonably foreseeable and will have a severe negative impact after the emergency. Therefore, we believe that it is essential to try to continue, as far as possible, the activity of clinical nutrition in oncology, by revolutionizing the setting and the approach to patients. For this purpose, the Clinical Nutrition and Dietetics Unit and the Medical Oncology Unit of our hospital, one of the largest community hospital in Lombardy that has been involved in the COVID-19 outbreak management since its inception, have reorganized the clinical routine activity in strict collaboration since the very beginning of the emergency, to better face up to the challenge, while preserving cancer patients' needs.
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- 2020
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30. Bioelectrical impedance vector analysis-derived phase angle predicts survival in patients with systemic immunoglobulin light-chain amyloidosis
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Mario Nuvolone, Francesca Lavatelli, Marilisa Caraccia, Andrea Foli, Valentina Martinelli, Paolo Milani, S. Masi, Catherine Klersy, Valeria Borioli, Giovanni Palladini, Silvia Cappello, Federica Lobascio, Marco Basset, Riccardo Caccialanza, Giampaolo Merlini, Annalisa Turri, and Emanuele Cereda
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Adult ,Male ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Immunoglobulin Light-chain Amyloidosis ,03 medical and health sciences ,0302 clinical medicine ,Nuclear magnetic resonance ,Internal Medicine ,Electric Impedance ,Medicine ,Humans ,In patient ,Prospective Studies ,Aged ,Proportional Hazards Models ,business.industry ,Phase angle ,Malnutrition ,Heart ,Prognosis ,Quality of Life ,Female ,Immunoglobulin Light Chains ,business ,Bioelectrical impedance analysis ,Value (mathematics) ,030217 neurology & neurosurgery - Abstract
Background: The aim of the present prospective study (ClinicalTrials.gov Identifier: NCT02111538) was to assess the prognostic value of phase angle (PhA), derived from bioimpedance vectorial analys...
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- 2020
31. Large Radio Telescopes for Anomalous Microwave Emission Observations
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E. S. Battistelli, E. Carretti, P. de Bernardis, and S. Masi
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Astronomy ,QB1-991 - Abstract
We discuss in this paper the problem of the Anomalous Microwave Emission (AME) in the light of ongoing or future observations to be performed with the largest fully steerable radio telescope in the world. High angular resolution observations of the AME will enable astronomers to drastically improve the knowledge of the AME mechanisms as well as the interplay between the different constituents of the interstellar medium in our galaxy. Extragalactic observations of the AME have started as well, and high resolution is even more important in this kind of observations. When cross-correlating with IR-dust emission, high angular resolution is also of fundamental importance in order to obtain unbiased results. The choice of the observational frequency is also of key importance in continuum observation. We calculate a merit function that accounts for the signal-to-noise ratio (SNR) in AME observation given the current state-of-the-art knowledge and technology. We also include in our merit functions the frequency dependence in the case of multifrequency observations. We briefly mention and compare the performance of four of the largest radiotelescopes in the world and hope the observational programs in each of them will be as intense as possible.
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- 2012
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32. 925TiP The efficacy of immunonutrition in improving tolerance to chemoradiotherapy in patients with head and neck cancer, receiving nutritional counseling: Study protocol of a randomized, open-label, parallel group, bicentric pilot study
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Mariateresa Nardi, V. Caissutti, L. Catenacci, E. Bonzano, Catherine Klersy, Paolo Pedrazzoli, Ilaria Imarisio, Paolo Bossi, Silvia Crotti, Patrizia Comoli, C. Brovia, Richard Tancredi, Emanuele Cereda, S. Masi, Riccardo Caccialanza, and Maria Grazia Ghi
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Protocol (science) ,medicine.medical_specialty ,business.industry ,Head and neck cancer ,Hematology ,medicine.disease ,Nutritional counseling ,Oncology ,Internal medicine ,medicine ,In patient ,Open label ,business ,Chemoradiotherapy - Published
- 2021
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33. Importance of body composition in grading body mass index and weight loss-related nutritional risk in cancer patients
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K Franz, Silvia Cappello, P. Pedrazzoli, N. Stobäus, M. Tank, Marco Benazzo, E. Giaquinto, S. Cutti, Federica Lobascio, Luca Arcaini, Emanuele Cereda, Andrea Riccardo Filippi, Annalisa Turri, Giovanni Palladini, Silvia Crotti, Valeria Borioli, Kristina Norman, Catherine Klersy, S. Masi, and Riccardo Caccialanza
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medicine.medical_specialty ,Nutrition and Dietetics ,Weight loss ,business.industry ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,medicine ,medicine.symptom ,business ,Grading (tumors) ,Body mass index ,Nutritional risk - Published
- 2020
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34. Updated design of the CMB polarization experiment satellite LiteBIRD
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H. Sugai, P. A. R. Ade, Y. Akiba, D. Alonso, K. Arnold, J. Aumont, J. Austermann, C. Baccigalupi, A. J. Banday, R. Banerji, R. B. Barreiro, S. Basak, J. Beall, S. Beckman, M. Bersanelli, J. Borrill, F. Boulanger, M. L. Brown, M. Bucher, A. Buzzelli, E. Calabrese, F. J. Casas, A. Challinor, V. Chan, Y. Chinone, J.-F. Cliche, F. Columbro, A. Cukierman, D. Curtis, P. Danto, P. de Bernardis, T. de Haan, M. De Petris, C. Dickinson, M. Dobbs, T. Dotani, L. Duband, A. Ducout, S. Duff, A. Duivenvoorden, J.-M. Duval, K. Ebisawa, T. Elleflot, H. Enokida, H. K. Eriksen, J. Errard, T. Essinger-Hileman, F. Finelli, R. Flauger, C. Franceschet, U. Fuskeland, K. Ganga, J.-R. Gao, R. Génova-Santos, T. Ghigna, A. Gomez, M. L. Gradziel, J. Grain, F. Grupp, A. Gruppuso, J. E. Gudmundsson, N. W. Halverson, P. Hargrave, T. Hasebe, M. Hasegawa, M. Hattori, M. Hazumi, S. Henrot-Versille, D. Herranz, C. Hill, G. Hilton, Y. Hirota, E. Hivon, R. Hlozek, D.-T. Hoang, J. Hubmayr, K. Ichiki, T. Iida, H. Imada, K. Ishimura, H. Ishino, G. C. Jaehnig, M. Jones, T. Kaga, S. Kashima, Y. Kataoka, N. Katayama, T. Kawasaki, R. Keskitalo, A. Kibayashi, T. Kikuchi, K. Kimura, T. Kisner, Y. Kobayashi, N. Kogiso, A. Kogut, K. Kohri, E. Komatsu, K. Komatsu, K. Konishi, N. Krachmalnicoff, C. L. Kuo, N. Kurinsky, A. Kushino, M. Kuwata-Gonokami, L. Lamagna, M. Lattanzi, A. T. Lee, E. Linder, B. Maffei, D. Maino, M. Maki, A. Mangilli, E. Martínez-González, S. Masi, R. Mathon, T. Matsumura, A. Mennella, M. Migliaccio, Y. Minami, K. Mistuda, D. Molinari, L. Montier, G. Morgante, B. Mot, Y. Murata, J. A. Murphy, M. Nagai, R. Nagata, S. Nakamura, T. Namikawa, P. Natoli, S. Nerval, T. Nishibori, H. Nishino, Y. Nomura, F. Noviello, C. O’Sullivan, H. Ochi, H. Ogawa, H. Ohsaki, I. Ohta, N. Okada, L. Pagano, A. Paiella, D. Paoletti, G. Patanchon, F. Piacentini, G. Pisano, G. Polenta, D. Poletti, T. Prouvé, G. Puglisi, D. Rambaud, C. Raum, S. Realini, M. Remazeilles, G. Roudil, J. A. Rubiño-Martín, M. Russell, H. Sakurai, Y. Sakurai, M. Sandri, G. Savini, D. Scott, Y. Sekimoto, B. D. Sherwin, K. Shinozaki, M. Shiraishi, P. Shirron, G. Signorelli, G. Smecher, P. Spizzi, S. L. Stever, R. Stompor, S. Sugiyama, A. Suzuki, J. Suzuki, E. Switzer, R. Takaku, H. Takakura, S. Takakura, Y. Takeda, A. Taylor, E. Taylor, Y. Terao, K. L. Thompson, B. Thorne, M. Tomasi, H. Tomida, N. Trappe, M. Tristram, M. Tsuji, M. Tsujimoto, C. Tucker, J. Ullom, S. Uozumi, S. Utsunomiya, J. Van Lanen, G. Vermeulen, P. Vielva, F. Villa, M. Vissers, N. Vittorio, F. Voisin, I. Walker, N. Watanabe, I. Wehus, J. Weller, B. Westbrook, B. Winter, E. Wollack, R. Yamamoto, N. Y. Yamasaki, M. Yanagisawa, T. Yoshida, J. Yumoto, M. Zannoni, A. Zonca, Sugai, H, Ade, P, Akiba, Y, Alonso, D, Arnold, K, Aumont, J, Austermann, J, Baccigalupi, C, Banday, A, Banerji, R, Barreiro, R, Basak, S, Beall, J, Beckman, S, Bersanelli, M, Borrill, J, Boulanger, F, Brown, M, Bucher, M, Buzzelli, A, Calabrese, E, Casas, F, Challinor, A, Chan, V, Chinone, Y, Cliche, J, Columbro, F, Cukierman, A, Curtis, D, Danto, P, de Bernardis, P, de Haan, T, De Petris, M, Dickinson, C, Dobbs, M, Dotani, T, Duband, L, Ducout, A, Duff, S, Duivenvoorden, A, Duval, J, Ebisawa, K, Elleflot, T, Enokida, H, Eriksen, H, Errard, J, Essinger-Hileman, T, Finelli, F, Flauger, R, Franceschet, C, Fuskeland, U, Ganga, K, Gao, J, Génova-Santos, R, Ghigna, T, Gomez, A, Gradziel, M, Grain, J, Grupp, F, Gruppuso, A, Gudmundsson, J, Halverson, N, Hargrave, P, Hasebe, T, Hasegawa, M, Hattori, M, Hazumi, M, Henrot-Versille, S, Herranz, D, Hill, C, Hilton, G, Hirota, Y, Hivon, E, Hlozek, R, Hoang, D, Hubmayr, J, Ichiki, K, Iida, T, Imada, H, Ishimura, K, Ishino, H, Jaehnig, G, Jones, M, Kaga, T, Kashima, S, Kataoka, Y, Katayama, N, Kawasaki, T, Keskitalo, R, Kibayashi, A, Kikuchi, T, Kimura, K, Kisner, T, Kobayashi, Y, Kogiso, N, Kogut, A, Kohri, K, Komatsu, E, Komatsu, K, Konishi, K, Krachmalnicoff, N, Kuo, C, Kurinsky, N, Kushino, A, Kuwata-Gonokami, M, Lamagna, L, Lattanzi, M, Lee, A, Linder, E, Maffei, B, Maino, D, Maki, M, Mangilli, A, Martínez-González, E, Masi, S, Mathon, R, Matsumura, T, Mennella, A, Migliaccio, M, Minami, Y, Mistuda, K, Molinari, D, Montier, L, Morgante, G, Mot, B, Murata, Y, Murphy, J, Nagai, M, Nagata, R, Nakamura, S, Namikawa, T, Natoli, P, Nerval, S, Nishibori, T, Nishino, H, Nomura, Y, Noviello, F, O’Sullivan, C, Ochi, H, Ogawa, H, Ohsaki, H, Ohta, I, Okada, N, Pagano, L, Paiella, A, Paoletti, D, Patanchon, G, Piacentini, F, Pisano, G, Polenta, G, Poletti, D, Prouvé, T, Puglisi, G, Rambaud, D, Raum, C, Realini, S, Remazeilles, M, Roudil, G, Rubiño-Martín, J, Russell, M, Sakurai, H, Sakurai, Y, Sandri, M, Savini, G, Scott, D, Sekimoto, Y, Sherwin, B, Shinozaki, K, Shiraishi, M, Shirron, P, Signorelli, G, Smecher, G, Spizzi, P, Stever, S, Stompor, R, Sugiyama, S, Suzuki, A, Suzuki, J, Switzer, E, Takaku, R, Takakura, H, Takakura, S, Takeda, Y, Taylor, A, Taylor, E, Terao, Y, Thompson, K, Thorne, B, Tomasi, M, Tomida, H, Trappe, N, Tristram, M, Tsuji, M, Tsujimoto, M, Tucker, C, Ullom, J, Uozumi, S, Utsunomiya, S, Van Lanen, J, Vermeulen, G, Vielva, P, Villa, F, Vissers, M, Vittorio, N, Voisin, F, Walker, I, Watanabe, N, Wehus, I, Weller, J, Westbrook, B, Winter, B, Wollack, E, Yamamoto, R, Yamasaki, N, Yanagisawa, M, Yoshida, T, Yumoto, J, Zannoni, M, Zonca, A, World Premier International Research Center (Japan), Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Agenzia Spaziale Italiana, Istituto Nazionale di Fisica Nucleare, Centre National D'Etudes Spatiales (France), Centre National de la Recherche Scientifique (France), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), European Space Agency, Canadian Space Agency, National Aeronautics and Space Administration (US), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National d’Études Spatiales [Paris] (CNES), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Hélium : du fondamental aux applications (NEEL - HELFA), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Sugai, H. [0000-0001-6501-3871], and Apollo - University of Cambridge Repository
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Passive cooling ,Cosmic Microwave Background, Cosmology, Polarimetry, Instrumentation, Inflation ,Cosmic microwave background ,cosmic background radiation: polarization ,7. Clean energy ,01 natural sciences ,Polarization ,General Materials Science ,010303 astronomy & astrophysics ,media_common ,Physics ,Settore FIS/01 ,Settore FIS/05 ,Astrophysics::Instrumentation and Methods for Astrophysics ,suppression ,Condensed Matter Physics ,Polarization (waves) ,Atomic and Molecular Physics, and Optics ,Infation ,adiabatic ,Astrophysics - Instrumentation and Methods for Astrophysics ,signature ,Astrophysics and Astronomy ,media_common.quotation_subject ,Lagrangian point ,Inflation ,Primordial gravitational wave ,Satellite ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Noise (electronics) ,Article ,NO ,FIS/05 - ASTRONOMIA E ASTROFISICA ,Settore FIS/05 - Astronomia e Astrofisica ,0103 physical sciences ,noise: thermal ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,010308 nuclear & particles physics ,Gravitational wave ,PE9_14 ,beam: width ,gravitational radiation: primordial ,Astronomy ,13. Climate action ,Sky ,spectral ,galaxy ,astro-ph.IM - Abstract
H. Sugai, et al., Recent developments of transition-edge sensors (TESs), based on extensive experience in ground-based experiments, have been making the sensor techniques mature enough for their application on future satellite cosmic microwave background (CMB) polarization experiments. LiteBIRD is in the most advanced phase among such future satellites, targeting its launch in Japanese Fiscal Year 2027 (2027FY) with JAXA’s H3 rocket. It will accommodate more than 4000 TESs in focal planes of reflective low-frequency and refractive medium-and-high-frequency telescopes in order to detect a signature imprinted on the CMB by the primordial gravitational waves predicted in cosmic inflation. The total wide frequency coverage between 34 and 448 GHz enables us to extract such weak spiral polarization patterns through the precise subtraction of our Galaxy’s foreground emission by using spectral differences among CMB and foreground signals. Telescopes are cooled down to 5 K for suppressing thermal noise and contain polarization modulators with transmissive half-wave plates at individual apertures for separating sky polarization signals from artificial polarization and for mitigating from instrumental 1/f noise. Passive cooling by using V-grooves supports active cooling with mechanical coolers as well as adiabatic demagnetization refrigerators. Sky observations from the second Sun–Earth Lagrangian point, L2, are planned for 3 years. An international collaboration between Japan, the USA, Canada, and Europe is sharing various roles. In May 2019, the Institute of Space and Astronautical Science, JAXA, selected LiteBIRD as the strategic large mission No. 2., This work was supported by World Premier International Research Center Initiative (WPI), MEXT, Japan, by JSPS Core-to-Core Program, A. Advanced Research Networks, and by JSPS KAKENHI Grant Numbers JP15H05891, JP17H01115, and JP17H01125. The Italian contribution to the LiteBIRD phase A is supported by the Italian Space Agency (ASI Grant No. 2016-24- H.1-2018) and the National Institute for Nuclear Physics (INFN). The French contribution to the LiteBIRD phase A is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifque (CNRS), and by the Commissariat à l’Energie Atomique (CEA). A Concurrent Design Facility study focused on the MHFT and Sub-Kelvin coolers has been led by the European Space Agency (ESA). The Canadian contribution to LiteBIRD is supported by the Canadian Space Agency. The US contribution is supported by NASA Grant no. 80NSSC18K0132
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- 2020
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35. Challenges to Backfilling an Existing Natural Gas Liquefaction Facility with Different Gas Specifications
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Ahmed Omar Abdelaziz, Christopher Cannell, Ahmed Shehata, Domenico Cannatelli, and S. Masi
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Petroleum engineering ,Environmental science ,Liquefied natural gas - Abstract
The design of new natural gas liquefaction facilities is closely aligned with the quality of the immediately available feed gas and the SPA’s agreed with customers. However, the lifetime of the facilities often extends beyond the lifetime of both the gas source and the duration of the SPA’s. Recent statistics indicate up to 60 MTPA of global liquefaction capacity is not utilized. Qualitative based approaches are often adopted to assess how an LNG plant responds to a change in feed gas specification. However a more valuable approach uses a quantitative analysis which can achieve an optimal outcome via individual tuning of a potentially large number of plant variables. Such an approach starts by performing actual plant capacity tests for different operating modes and process variables to capture baseline operation performance data. The plant test results are to validate a detailed plant simulation model which includes all the plant variables of interest. The validated model can then help identify the optimum operating condition and the benefits of a range of potential modifications. The methodology was used to identify solutions to a typical problem in a multi-train facility where a change from rich feed stock was accompanied by the presence of aromatics in a significantly leaner feed gas. Detailed modelling of the plant enabled an understanding of the solubility of the aromatics in the lean gas. The previously validated model of the real plant behaviour was then used to evaluate the benefits of changes to the key operating parameters and minor modifications to the plant itself. This resulted in a significantly more efficient and cost-effective solution than simply importing LPG which would have been the solution normally taken by a traditional "qualitative" approach. A similar approach was used to address an associated commercial challenge of satisfying a SPA demanding a high HHV with a leaner feed gas. In this case the solution relied not only on the technical insight afforded by the quantitative analysis but also a recognition that accurate tuning of the operational process allows a reduction in the conservatism of the product specification. Furthermore, with minor modifications, a multi-train process with segregated storage can be operated in multiple HHV mode provided careful procedures are employed to mitigate operational risks. This paper demonstrates how a holistic, detailed, quantitative analysis of gas liquefaction process can provide a good insight into the capability of existing plant to respond to changes in feedstock quality. The outlined methodology combined with a good understanding of the commercial features of the LNG business offers the possibility to better exploit the significant and growing amount of unused gas liquefaction capacity around the world.
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- 2019
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36. P1566Identification of the cardiovascular threshold limit for serum uric acid. Analysis from a general Italian population
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Edoardo Casiglia, Agostino Virdis, Tikhonoff, Claudia Borghi, M.L. Muiesan, Giovambattista Desideri, S Masi, and Guido Grassi
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medicine.medical_specialty ,business.industry ,Serum uric acid ,Hypertension chronic ,medicine.disease ,Italian population ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,Diabetes mellitus ,medicine ,Uric acid ,LDL Cholesterol Lipoproteins ,Limit (mathematics) ,Hyperuricemia ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Serum uric acid (SUA) is increasingly recognised as an important predictor of cardiovascular disease (CVD) and total mortality. However, the levels of SUA that discriminate across the different strata of risk for CVD and total mortality remain unknown, complicating the identification of subjects at high or low mortality risk for SUA in clinical practice. Purpose In this study we used a large Italian population comprising >3ehz748.0326 subjects to assess the threshold of SUA that increases the risk of total and CVD mortality. Methods The URic Acid Right for heArt Health (URRAH) study is a regional-basis multicentre cohort study which collected data from prospective studies and databases from different hypertension centres, including subjects with at least one measure of SUA and a follow-up of about 20 years. Total mortality was defined as mortality for any causes, cardiovascular mortality as death due to fatal myocardial infraction, stroke or heart failure. Multivariate dichotomic logistic and Cox regression models were used to confirm the relationship between SUA and mortality status both from cardiovascular and any causes, while ROC curves were used to identify the threshold of SUA that better discriminated people at higher or lower mortality risk. Results A total of 22.275 subjects had SUA and mortality information. Logistic regression identified a direct and strong association between SUA and an increased risk of total (OR 1.176, 95% CI 1.127–1.227) and CVD (OR 1.147, 95% CI 1.093–1.203) mortality, independently of other CVD risk factors (age, BMI, LDL cholesterol, diagnosis of diabetes, hypertension, chronic kidney disease, alcohol consumption and smoking). Cox models confirmed the presence of an independent association between SUA and any causes (HR 1.123, 95% CI 1.090–1.567) and CVD (HR 1.124, 95% CI 1.081–1.169) mortality. ROC curve analysis identified a cut-off value od SUA [(4.79 mg/dL (95% CI 4.7–5.4 mg/dl)] able to discriminate total mortality status, and a different one [(5.60 mg/dL (95% CI 5.09–5.89 mg/dl)] able to identify CVD mortality status. Multivariate Cox analysis adjusted for confounders confirmed that subjects with SUA >4.79 mg/dl had a significantly higher total mortality (HR 1.293, 95% CI 1.181–1.416) compared to those with SUA 5.60 mg/dl had a significantly higher CVD mortality (HR 1.428, 95% CI 1.273–1.600) than those with SUA Conclusion Levels of SUA that increase the risk of total and CVD mortality are significantly lower than those commonly used for the definition of hyperuricemia in clinical practice. Our data provide the first large evidence of a level of “cardiovascular” SUA that might be used in clinical practice to identify subjects at greater risk of total and CVD mortality.
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- 2019
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37. QUBIC: the Q \& U Bolometric Interferometer for Cosmology
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E. S. Battistelli, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, S. Banfi, P. Battaglia, A. Baù, B. Bélier, D. Bennett, L. Bergé, J.-Ph. Bernard, M. Bersanelli, M.-A. Bigot-Sazy, N. Bleurvacq, J. Bonaparte, J. Bonis, A. Bottani, E. Bunn, D. Burke, D. Buzi, A. Buzzelli, F. Cavaliere, P. Chanial, C. Chapron, R. Charlassier, F. Columbro, G. Coppi, A. Coppolecchia, G. D’Alessandro, P. de Bernardis, G. De Gasperis, M. De Leo, M. De Petris, S. Dheilly, A. Di Donato, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, C. Franceschet, M. M. Gamboa Lerena, K. Ganga, B. García, M. E. García Redondo, M. Gaspard, A. Gault, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. Gómez Berisso, M. González, M. Gradziel, L. Grandsire, J.-Ch. Hamilton, D. Harari, V. Haynes, S. Henrot-Versillé, D. T. Hoang, F. Incardona, E. Jules, J. Kaplan, A. Korotkov, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, R. Luterstein, B. Maffei, S. Marnieros, W. Marty, S. Masi, A. Mattei, A. May, M. McCulloch, M. C. Medina, L. Mele, S. Melhuish, A. Mennella, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, C. O’Sullivan, A. Paiella, F. Pajot, A. Passerini, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Pezzotta, F. Piacentini, M. Piat, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, P. Ringegni, G. E. Romero, M. Salatino, J. M. Salum, A. Schillaci, C. Scóccola, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, F. Suarez, A. Tartari, J.-P. Thermeau, P. Timbie, M. Tomasi, S. Torchinsky, M. Tristram, C. Tucker, G. Tucker, S. Vanneste, D. Viganò, N. Vittorio, F. Voisin, B. Watson, F. Wicek, M. Zannoni, A. Zullo, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), QUBIC, Battistelli, E, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Battaglia, P, Bau, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bleurvacq, N, Bonaparte, J, Bonis, J, Bottani, A, Bunn, E, Burke, D, Buzi, D, Buzzelli, A, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Columbro, F, Coppi, G, Coppolecchia, A, D’Alessandro, G, de Bernardis, P, De Gasperis, G, De Leo, M, De Petris, M, Dheilly, S, Di Donato, A, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Lerena, M, Ganga, K, García, B, Redondo, M, Gaspard, M, Gault, A, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Berisso, M, González, M, Gradziel, M, Grandsire, L, Hamilton, J, Harari, D, Haynes, V, Henrot-Versillé, S, Hoang, D, Incardona, F, Jules, E, Kaplan, J, Korotkov, A, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Luterstein, R, Maffei, B, Marnieros, S, Marty, W, Masi, S, Mattei, A, May, A, Mcculloch, M, Medina, M, Mele, L, Melhuish, S, Mennella, A, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, O’Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piat, M, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Salatino, M, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Suarez, F, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Torchinsky, S, Tristram, M, Tucker, C, Tucker, G, Vanneste, S, Viganò, D, Vittorio, N, Voisin, F, Watson, B, Wicek, F, Zannoni, M, Zullo, A, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Zmuidzinas, J, Gao, JR, De Bernardis, P, Dalessandro, G, Hoang, T, Osullivan, C, Prele, D, Belier, B, Berge, L, Cobos Cerutti, A, Duca, C, Gamboa Lerena, M, Garcia, B, Garcia Redondo, M, Gomez Berisso, M, Gonzalez, M, Hampel, M, Henrot-Versille, S, Melo, D, Olivicri, E, Rasztocky, E, Scoccola, C, Supanitsky, A, Vigano, D, Wright, M, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)
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cosmological model ,[SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO] ,Ciencias Físicas ,electormagnetics ,cosmic background radiation: polarization ,cosmic background radiation ,Cosmic microwave background ,cosmology ,gravitational waves ,polarization ,bolometric interferometer ,stokes polarimeter ,transition-edge sensors ,01 natural sciences ,Stokes polarimeter ,purl.org/becyt/ford/1 [https] ,SPIE Proceeding ,Polarization ,propagation ,ultraviolet ,optical ,site ,General Materials Science ,010303 astronomy & astrophysics ,ComputingMilieux_MISCELLANEOUS ,Microwave measurement ,Settore FIS/05 ,Astrophysics::Instrumentation and Methods for Astrophysics ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Cosmology ,physical optics ,Optical interferometry ,[PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc] ,Cosmic Microwave Background, Polarization, Cosmology, Experimental ,Astrophysics - Instrumentation and Methods for Astrophysics ,CIENCIAS NATURALES Y EXACTAS ,signature ,Manuscript format ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Transition-edge sensors ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,detector: cryogenics ,LaTeX ,interferometer ,FOS: Physical sciences ,anisotropy ,Astrophysics::Cosmology and Extragalactic Astrophysics ,microwaves ,Gravitational waves ,FIS/05 - ASTRONOMIA E ASTROFISICA ,bolometer ,0103 physical sciences ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,inflation ,010306 general physics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Ultraviolet sources ,Q measurement ,beam propagation ,Template ,Bolometric interferometer ,purl.org/becyt/ford/1.3 [https] ,Optical propagation ,sensitivity ,optics ,Optical polarization ,Astronomía ,Instruments ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] - Abstract
The Q & U Bolometric Interferometer for Cosmology, QUBIC, is an innovative experiment designed to measure the polarization of the Cosmic Microwave Background and in particular the signature left therein by the inflationary expansion of the Universe. The expected signal is extremely faint, thus extreme sensitivity and systematic control are necessary in order to attempt this measurement. QUBIC addresses these requirements using an innovative approach combining the sensitivity of Transition Edge Sensor cryogenic bolometers, with the deep control of systematics characteristic of interferometers. This makes QUBIC unique with respect to others classical imagers experiments devoted to the CMB polarization. In this contribution we report a description of the QUBIC instrument including recent achievements and the demonstration of the bolometric interferometry performed in lab. QUBIC will be deployed at the observation site in Alto Chorrillos, in Argentina at the end of 2019., Accepted for publication in the Journal of Low Temperature Physics
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- 2019
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38. RELATIONSHIP BETWEEN DIURETIC RELATED HYPERURICEMIA AND CARDIOVASCULAR EVENTS: DATA FROM THE URRAH (URIC ACID RIGHT FOR HEART HEALTH) STUDY
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Alessandro Maloberti, M. Bombelli, R. Facchetti, A. Virdis, E. Casiglia, V. Tikhonoff, C.m. Barbagallo, M. Cirillo, G. Desideri, C. Ferri, F. Galletti, G. Iaccarino, F. Mallamaci, S. Masi, A. Mazza, M.l. Muiesan, M. Salvetti, P. Palatini, R. Pontremoli, P. Verdecchia, M. Volpe, G. Grassi, C. Giannattasio, and C. Borghi
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Physiology ,Internal Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2021
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39. The efficacy of immunonutrition in improving tolerance to chemoradiotherapy in patients with head and neck cancer, receiving nutritional counseling: study protocol of a randomized, open-label, parallel group, bicentric pilot study
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Silvia Crotti, Elena Formisano, Richard Tancredi, Teresa Monaco, Sara Colombo, Elisabetta Bonzano, Ilaria Imarisio, S. Masi, Valentina Caissutti, Patrizia Comoli, Alessandra Ferrari, Andrea Riccardo Filippi, Paolo Bossi, Silvia Cappello, Carlotta Brovia, Catherine Klersy, Riccardo Caccialanza, Valeria Musella, Andrea Alberti, Maria Grazia Ghi, Laura Catenacci, Mariateresa Nardi, Federica Lobascio, Paolo Pedrazzoli, and Emanuele Cereda
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medicine.medical_specialty ,nutritional counseling ,treatment tolerance ,business.industry ,Head and neck cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cancer ,malnutrition ,Treatment tolerance ,medicine.disease ,chemoradiotherapy ,Nutritional counseling ,Study Protocol ,Oncology ,head and neck cancer ,immunonutrition ,Internal medicine ,medicine ,In patient ,Open label ,Head and neck ,business ,RC254-282 ,Chemoradiotherapy - Abstract
Background: Nutritional support, including nutritional counseling and oral nutritional supplements (ONSs), has been recommended at the earliest opportunity in head and neck (H&N) cancer patients. The limited available evidence on the efficacy of immunonutrition during chemoradiotherapy (CT-RT) in H&N cancer patients is positive with regard to some secondary endpoints, but is still scanty, particularly with regard to toxicity and treatment tolerance. We hypothesize that early systematic provision of ONSs with a high-protein–high-calorie mixture containing immunonutrients (Impact) compared to standard high-calorie–high-protein nutritional blends, in addition to nutritional counseling, may be beneficial to patients with H&N cancer during CT-RT. Hence, we designed the present study to evaluate the efficacy, in terms of treatment tolerance, toxicity and response, body weight, body composition, protein-calorie intake, quality of life (QoL), fatigue, muscle strength and immunological profile of the early systematic provision of ONSs enriched in immunonutrients compared to isonitrogenous standard blends, in H&N cancer patients undergoing CT-RT. Methods: This is a pragmatic, bicentric, randomized (1:1), parallel-group, open label, controlled, pilot clinical trial. Discussion: Many efforts are still to be taken to improve the efficacy of nutritional support in oncology. Immunonutrition represents a promising approach also in H&N cancer patients, but the evidence on its efficacy in improving clinical outcomes during CT-RT is still inconclusive. The present pilot study, which guarantees the early provision of nutritional assessment and support to all the enrolled patients in accordance with the recent guidelines and recommendations, could represent one of the first proofs of the clinical effectiveness of early oral immunonutrition in cancer patients undergoing CT-RT and could stimulate further large randomized trials, potentially resulting in the improvement of supportive care quality. Trial registration: This study is registered on ClinicalTrials.gov Identifier: NCT04611113.
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- 2021
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40. The need to reappraise the definition of sarcopenia in cancer patients
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S. Masi, Riccardo Caccialanza, Emanuele Cereda, Andrea Riccardo Filippi, Federica Lobascio, M. Tank, Silvia Cappello, N. Stobäus, Kristina Norman, S. Cutti, Silvia Crotti, Marco Benazzo, Valeria Borioli, K Franz, Giovanni Palladini, P. Pedrazzoli, Luca Arcaini, Catherine Klersy, and Annalisa Turri
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medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Sarcopenia ,medicine ,Cancer ,medicine.disease ,Intensive care medicine ,business - Published
- 2020
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41. VALIDATION OF A NEW PROGNOSTIC BODY COMPOSITION PARAMETER IN CANCER PATIENTS
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Marilisa Caraccia, S. Masi, Kristina Norman, Antonello Giannoni, Riccardo Caccialanza, Emanuele Cereda, Valeria Borioli, and Federica Lobascio
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Creatinine ,medicine.medical_specialty ,Nutrition and Dietetics ,Performance status ,business.industry ,Endocrinology, Diabetes and Metabolism ,Cancer ,Disease ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Weight loss ,Internal medicine ,Cohort ,Clinical endpoint ,Medicine ,medicine.symptom ,Stage (cooking) ,business - Abstract
We evaluated the prognostic value of a new body composition parameter (creatinine height index [CHI]) obtained from bioimpedance vectorial analysis-derived body cell mass and its association with nutritional and functional status. Data of Italian and German cancer patients observed prospectively until death were used (N=1084). Multivariable models (adjusted for age, gender, hydration status, performance status, disease's stage) were built in both cohorts to assess the association between body composition outcome parameters (low fat-free mass, 70 years] kg/m2), clinically significant weight loss (>10% in 6 months) and low handgrip strength ( Low CHI was independently associated with mortality in both Italian (HR=1.84 [95%CI, 1.18-2.86]; P=0.007) and German cohorts (HR=1.52 [95%CI, 1.17-2.07]; P=0.008). Low FFMI and low SPA did not predict survival in the German cohort. In patients with low CHI, worse nutritional and functional status were observed in both study populations. Performance of models addressing the study endpoints showed substantial consistency with both cohorts, particularly of those including low CHI. We validated a new prognostic body composition parameter, which is easier to interpret than standard nutritional parameters and may be useful for identifying cancer patients at nutritional risk, requiring early nutritional support. Its prognostic value should be confirmed in other patient populations and its sensitivity in detecting changes in protein-calorie intake is still to be investigated.
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- 2020
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42. Relationship between albuminuric CKD and diabetic retinopathy in a real-world setting of type 2 diabetes: Findings from No blind study
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Ciro Costagliola, Valeria Bono, C. de Sio, Luigi Elio Adinolfi, Luca Rinaldi, Teresa Salvatore, Dario Giugliano, Gabriele Riccardi, G. De Simone, Carlo Acierno, Ferdinando Carlo Sasso, Aldo Gelso, L. De Nicola, Alfredo Caturano, Ornella Carbonara, Raffaele Galiero, Lutgarda Bozzetto, R. Di Palo, L. Lucibelli, Vincenzo Guardasole, Riccardo Nevola, S. Masi, Maria Ida Maiorino, Celestino Sardu, M. Riccio, Pia Clara Pafundi, Raffaele Marfella, Roberto Minutolo, Sasso, F. C., Pafundi, P. C., Gelso, A., Bono, V., Costagliola, C., Marfella, R., Sardu, C., Rinaldi, L., Galiero, R., Acierno, C., Caturano, A., de Sio, C., De Nicola, L., Salvatore, T., Nevola, R., Adinolfi, L. E., Minutolo, R., Giugliano, D., Maiorino, M. I., Riccardi, G., Bozzetto, L., Guardasole, V., Di Palo, R., Carbonara, O., Riccio, M., De Simone, G., Lucibelli, L., and Masi, S.
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Male ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Albumin excretion rate ,Medicine (miscellaneous) ,Renal function ,030209 endocrinology & metabolism ,Disease ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Kidney ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Blind study ,Risk Factors ,Internal medicine ,medicine ,Humans ,Albuminuria ,Diabetic Nephropathies ,Diabetic kidney disease ,Renal Insufficiency, Chronic ,Aged ,Cross-Sectional Studie ,Nutrition and Dietetics ,Diabetic Retinopathy ,business.industry ,Risk Factor ,Diabetic retinopathy ,Middle Aged ,medicine.disease ,Glomerular filtration rate ,Renal Elimination ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Italy ,Diabetic Nephropathie ,Population study ,Female ,Cardiology and Cardiovascular Medicine ,business ,Kidney disease ,Human - Abstract
Background and aims: Recently, the albuminocentric view of diabetic kidney disease (DKD) in type 2 diabetes (T2DM) has been changing. Therefore, the relationship between diabetic retinopathy (DR) and chronic kidney disease (CKD) has to be addressed according to this new clinical presentation of DKD. The aim of this study was to evaluate, in a real-world setting, the correlation DR–DKD in T2DM. Methods and results: A total of 2068 type 2 diabetic patients enrolled in a multicenter cross-sectional study were investigated. Albuminuric subjects were largely prevalent among subjects with DR (p = 0.019). In the whole study population, no difference in albumin excretion rate (AER) was observed between presence/absence of DR; instead, AER was significantly higher among patients with glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 (CKD) (p = 0.009), above all in those with CKD and AER ≥0.03 g/24 h (p = 0.005). Multivariate analysis confirmed that eGFR (O.R. 0.976; 95% C.I.: 0.960–1.028; p < 0.001) and AER (O.R. 1.249; 95% C.I. 1.001–1.619; p = 0.004) were independently associated with DR and HDL–cholesterol (O.R.: 1.042; 95% C.I.: 1.011–1.120; p = 0.014). Additionally, among patients with eGFR
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- 2019
43. Association between blood pressure variability, cardiovascular disease and mortality in type 2 diabetes: A systematic review and meta-analysis
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Chiriacò, M. Pateras, K. Virdis, A. Charakida, M. Kyriakopoulou, D. Nannipieri, M. Emdin, M. Tsioufis, K. Taddei, S. Masi, S. Georgiopoulos, G.
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cardiovascular diseases - Abstract
Aim: To investigate the associations of blood pressure variability (BPV), expressed as long-term (visit-to-visit) and short-term (ambulatory blood pressure monitoring [ABPM] and home blood pressure monitoring [HBPM]) and all-cause mortality, major adverse cardiovascular events (MACEs), extended MACEs, microvascular complications (MiCs) and hypertension-mediated organ damage (HMOD) in adult patients with type 2 diabetes. Materials and methods: PubMed, Medline, Embase, Cinahl, Web of Science, ClinicalTrials.gov and grey literature databases were searched for studies including patients with type 2 diabetes, at least one variable of BPV (visit-to-visit, HBPM, ABPM) and evaluation of the incidence of at least one of the following outcomes: all-cause mortality, MACEs, extended MACEs and/or MiCs and/or HMOD. The extracted information was analyzed using random effects meta-analysis and meta-regression. Results: Data from a total of 377 305 patients were analyzed. Systolic blood pressure (SBP) variability was associated with a significantly increased risk of all-cause mortality (HR 1.12, 95% CI 1.04–1.21), MACEs (HR 1.01, 95% CI 1.04–1.17), extended MACEs (HR 1.07, 95% CI 1.03–1.11) and MiCs (HR 1. 12, 95% CI 1.01–1.24), while diastolic blood pressure was not. Associations were mainly driven from studies on long-term SBP variability. Qualitative analysis showed that BPV was associated with the presence of HMOD expressed as carotid intima-media thickness, pulse wave velocity and left ventricular hypertrophy. Results were independent of mean blood pressure, glycaemic control and serum creatinine levels. Conclusions: Our results suggest that BPV might provide additional information rather than mean blood pressure on the risk of cardiovascular disease in patients with type 2 diabetes. © 2019 John Wiley & Sons Ltd
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- 2019
44. Determination of the cloud base height by means of digital stereoscopic vision
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E Wolfram, J Salvador, S Verrastro, W S Masi, and R Rodriguez Colmeiro
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Stereopsis ,Computer science ,business.industry ,General Physics and Astronomy ,Computer vision ,Cloud computing ,Artificial intelligence ,Base (topology) ,business - Published
- 2015
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45. Exploring cosmic origins with CORE: Inflation
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F. Finelli, M. Bucher, A. Achúcarro, M. Ballardini, N. Bartolo, D. Baumann, S. Clesse, J. Errard, W. Handley, M. Hindmarsh, K. Kiiveri, M. Kunz, A. Lasenby, M. Liguori, D. Paoletti, C. Ringeval, J. Väliviita, B. van Tent, V. Vennin, P. Ade, R. Allison, F. Arroja, M. Ashdown, A.J. Banday, R. Banerji, J.G. Bartlett, S. Basak, P. de Bernardis, M. Bersanelli, A. Bonaldi, J. Borril, F.R. Bouchet, F. Boulanger, T. Brinckmann, C. Burigana, A. Buzzelli, Z.-Y. Cai, M. Calvo, C.S. Carvalho, G. Castellano, A. Challinor, J. Chluba, I. Colantoni, A. Coppolecchia, M. Crook, G. D'Alessandro, G. D'Amico, J. Delabrouille, V. Desjacques, G. De Zotti, J.M. Diego, E. Di Valentino, S. Feeney, J.R. Fergusson, R. Fernandez-Cobos, S. Ferraro, F. Forastieri, S. Galli, J. García-Bellido, G. de Gasperis, R.T. Génova-Santos, M. Gerbino, J. González-Nuevo, S. Grandis, J. Greenslade, S. Hagstotz, S. Hanany, D.K. Hazra, C. Hernández-Monteagudo, C. Hervias-Caimapo, M. Hills, E. Hivon, B. Hu, T. Kisner, T. Kitching, E.D. Kovetz, H. Kurki-Suonio, L. Lamagna, M. Lattanzi, J. Lesgourgues, A. Lewis, V. Lindholm, J. Lizarraga, M. López-Caniego, G. Luzzi, B. Maffei, N. Mandolesi, E. Martínez-González, C.J.A.P. Martins, S. Masi, D. McCarthy, S. Matarrese, A. Melchiorri, J.-B. Melin, D. Molinari, A. Monfardini, P. Natoli, M. Negrello, A. Notari, F. Oppizzi, A. Paiella, E. Pajer, G. Patanchon, S.P. Patil, M. Piat, G. Pisano, L. Polastri, G. Polenta, A. Pollo, V. Poulin, M. Quartin, A. Ravenni, M. Remazeilles, A. Renzi, D. Roest, M. Roman, J.A. Rubiño-Martin, L. Salvati, A.A. Starobinsky, A. Tartari, G. Tasinato, M. Tomasi, J. Torrado, N. Trappe, T. Trombetti, M. Tucci, C. Tucker, J. Urrestilla, R. van de Weygaert, P. Vielva, N. Vittorio, K. Young, M. Zannoni, ITA, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut Lagrange de Paris, Sorbonne Université (SU), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Nanosciences et Cryogénie (INAC), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département de Physique des Particules (ex SPP) (DPP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), CORE, Department of Physics, Helsinki Institute of Physics, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Sorbonne Universités, Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Finelli, F, Bucher, M, Achúcarro, A, Ballardini, M, Bartolo, N, Baumann, D, Clesse, S, Errard, J, Handley, W, Hindmarsh, M, Kiiveri, K, Kunz, M, Lasenby, A, Liguori, M, Paoletti, D, Ringeval, C, Väliviita, J, Tent, B, Vennin, V, Ade, P, Allison, R, Arroja, F, Ashdown, M, Banday, A, Banerji, R, Bartlett, J, Basak, S, de Bernardis, P, Bersanelli, M, Bonaldi, A, Borril, J, Bouchet, F, Boulanger, F, Brinckmann, T, Burigana, C, Buzzelli, A, Cai, Z, Calvo, M, Carvalho, C, Castellano, G, Challinor, A, Chluba, J, Colantoni, I, Coppolecchia, A, Crook, M, D'Alessandro, G, D'Amico, G, Delabrouille, J, Desjacques, V, Zotti, G, Diego, J, Valentino, E, Feeney, S, Fergusson, J, Fernandez-Cobos, R, Ferraro, S, Forastieri, F, Galli, S, García-Bellido, J, de Gasperis, G, Génova-Santos, R, Gerbino, M, González-Nuevo, J, Grandis, S, Greenslade, J, Hagstotz, S, Hanany, S, Hazra, D, Hernández-Monteagudo, C, Hervias-Caimapo, C, Hills, M, Hivon, E, Hu, B, Kisner, T, Kitching, T, Kovetz, E, Kurki-Suonio, H, Lamagna, L, Lattanzi, M, Lesgourgues, J, Lewis, A, Lindholm, V, Lizarraga, J, López-Caniego, M, Luzzi, G, Maffei, B, Mandolesi, N, Martínez-González, E, Martins, C, Masi, S, Mccarthy, D, Matarrese, S, Melchiorri, A, Melin, J, Molinari, D, Monfardini, A, Natoli, P, Negrello, M, Notari, A, Oppizzi, F, Paiella, A, Pajer, E, Patanchon, G, Patil, S, Piat, M, Pisano, G, Polastri, L, Polenta, G, Pollo, A, Poulin, V, Quartin, M, Ravenni, A, Remazeilles, M, Renzi, A, Roest, D, Roman, M, Rubiño-Martin, J, Salvati, L, Starobinsky, A, Tartari, A, Tasinato, G, Tomasi, M, Torrado, J, Trappe, N, Trombetti, T, Tucci, M, Tucker, C, Urrestilla, J, de Weygaert, R, Vielva, P, Vittorio, N, Young, K, Zannoni, M, Finelli F., Bucher M., Achucarro A., Ballardini M., Bartolo N., Baumann D., Clesse S., Errard J., Handley W., Hindmarsh M., Kiiveri K., Kunz M., Lasenby A., Liguori M., Paoletti D., Ringeval C., Valiviita J., Tent B.V., Vennin V., Ade P., Allison R., Arroja F., Ashdown M., Banday A.J., Banerji R., Bartlett J.G., Basak S., De Bernardis P., Bersanelli M., Bonaldi A., Borril J., Bouchet F.R., Boulanger F., Brinckmann T., Burigana C., Buzzelli A., Cai Z.-Y., Calvo M., Carvalho C.S., Castellano G., Challinor A., Chluba J., Colantoni I., Coppolecchia A., Crook M., D'Alessandro G., D'Amico G., Delabrouille J., Desjacques V., Zotti G.D., Diego J.M., Valentino E.D., Feeney S., Fergusson J.R., Fernandez-Cobos R., Ferraro S., Forastieri F., Galli S., Garcia-Bellido J., De Gasperis G., Genova-Santos R.T., Gerbino M., Gonzalez-Nuevo J., Grandis S., Greenslade J., Hagstotz S., Hanany S., Hazra D.K., Hernandez-Monteagudo C., Hervias-Caimapo C., Hills M., Hivon E., Hu B., Kisner T., Kitching T., Kovetz E.D., Kurki-Suonio H., Lamagna L., Lattanzi M., Lesgourgues J., Lewis A., Lindholm V., Lizarraga J., Lopez-Caniego M., Luzzi G., Maffei B., Mandolesi N., Martinez-Gonzalez E., Martins C.J.A.P., Masi S., McCarthy D., Matarrese S., Melchiorri A., Melin J.-B., Molinari D., Monfardini A., Natoli P., Negrello M., Notari A., Oppizzi F., Paiella A., Pajer E., Patanchon G., Patil S.P., Piat M., Pisano G., Polastri L., Polenta G., Pollo A., Poulin V., Quartin M., Ravenni A., Remazeilles M., Renzi A., Roest D., Roman M., Rubino-Martin J.A., Salvati L., Starobinsky A.A., Tartari A., Tasinato G., Tomasi M., Torrado J., Trappe N., Trombetti T., Tucci M., Tucker C., Urrestilla J., De Weygaert R.V., Vielva P., Vittorio N., Young K., Zannoni M., String Theory (ITFA, IoP, FNWI), High-Energy Frontier, Astronomy, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Cryogénie (NEEL - Cryo), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Département de Physique des Particules (ex SPP) (DPhP), and Hélium : du fondamental aux applications (NEEL - HELFA)
- Subjects
cosmological model ,reheating ,Cosmic microwave background ,cosmic background radiation: polarization ,SPECTRAL DISTORTIONS ,astro-ph.CO ,Astrophysics ,cosmic background radiation ,7. Clean energy ,01 natural sciences ,GRAVITATIONAL-WAVES ,law.invention ,law ,010303 astronomy & astrophysics ,CMBR theory ,ination ,Astronomy and Astrophysics ,CMBR theory, inflation ,QC ,QB ,Physics ,COSMIC cancer database ,ST/J005673/1 ,ST/H008586/1 ,inflation: model ,MICROWAVE BACKGROUND ANISOTROPY ,Core inflation ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Big Bang ,scale: grand unified theory ,Astrophysics and Astronomy ,noise ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,STANDARD MODEL ,satellite ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,isocurvature: perturbation ,frequency: high ,PRIMORDIAL NON-GAUSSIANITY ,NO ,Telescope ,power spectrum: primordial ,FIS/05 - ASTRONOMIA E ASTROFISICA ,Settore FIS/05 - Astronomia e Astrofisica ,LARGE-SCALE STRUCTURE ,0103 physical sciences ,inflation ,cosmic string ,STFC ,MODEL SELECTION ,Inflation (cosmology) ,non-Gaussianity: primordial ,ST/K00333X/1 ,ISOCURVATURE PERTURBATIONS ,010308 nuclear & particles physics ,string tension ,big bang ,inflation: slow-roll approximation ,RCUK ,Spectral density ,115 Astronomy, Space science ,cosmic background radiation: temperature ,Cosmic string ,detector: sensitivity ,angular resolution ,13. Climate action ,PRE-BIG-BANG ,BAYESIAN-INFERENCE ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,cosmic background radiation: anisotropy - Abstract
We forecast the scientific capabilities to improve our understanding of cosmic inflation of CORE, a proposed CMB space satellite submitted in response to the ESA fifth call for a medium-size mission opportunity. The CORE satellite will map the CMB anisotropies in temperature and polarization in 19 frequency channels spanning the range 60-600 GHz. CORE will have an aggregate noise sensitivity of $1.7 ��$K$\cdot \,$arcmin and an angular resolution of 5' at 200 GHz. We explore the impact of telescope size and noise sensitivity on the inflation science return by making forecasts for several instrumental configurations. This study assumes that the lower and higher frequency channels suffice to remove foreground contaminations and complements other related studies of component separation and systematic effects, which will be reported in other papers of the series "Exploring Cosmic Origins with CORE." We forecast the capability to determine key inflationary parameters, to lower the detection limit for the tensor-to-scalar ratio down to the $10^{-3}$ level, to chart the landscape of single field slow-roll inflationary models, to constrain the epoch of reheating, thus connecting inflation to the standard radiation-matter dominated Big Bang era, to reconstruct the primordial power spectrum, to constrain the contribution from isocurvature perturbations to the $10^{-3}$ level, to improve constraints on the cosmic string tension to a level below the presumptive GUT scale, and to improve the current measurements of primordial non-Gaussianities down to the $f_{NL}^{\rm local} < 1$ level. For all the models explored, CORE alone will improve significantly on the present constraints on the physics of inflation. Its capabilities will be further enhanced by combining with complementary future cosmological observations., Latex 107 pages, revised with updated author list and minor modifications
- Published
- 2018
- Full Text
- View/download PDF
46. Exploring cosmic origins with CORE: Gravitational lensing of the CMB
- Author
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A. Challinor, R. Allison, J. Carron, J. Errard, S. Feeney, T. Kitching, J. Lesgourgues, A. Lewis, Í. Zubeldía, A. Achucarro, P. Ade, M. Ashdown, M. Ballardini, A.J. Banday, R. Banerji, J. Bartlett, N. Bartolo, S. Basak, D. Baumann, M. Bersanelli, A. Bonaldi, M. Bonato, J. Borrill, F. Bouchet, F. Boulanger, T. Brinckmann, M. Bucher, C. Burigana, A. Buzzelli, Z.-Y. Cai, M. Calvo, C.-S. Carvalho, G. Castellano, J. Chluba, S. Clesse, I. Colantoni, A. Coppolecchia, M. Crook, G. d'Alessandro, P. de Bernardis, G. de Gasperis, G. De Zotti, J. Delabrouille, E. Di Valentino, J.-M. Diego, R. Fernandez-Cobos, S. Ferraro, F. Finelli, F. Forastieri, S. Galli, R. Genova-Santos, M. Gerbino, J. González-Nuevo, S. Grandis, J. Greenslade, S. Hagstotz, S. Hanany, W. Handley, C. Hernandez-Monteagudo, C. Hervías-Caimapo, M. Hills, E. Hivon, K. Kiiveri, T. Kisner, M. Kunz, H. Kurki-Suonio, L. Lamagna, A. Lasenby, M. Lattanzi, M. Liguori, V. Lindholm, M. López-Caniego, G. Luzzi, B. Maffei, E. Martinez-González, C.J.A.P. Martins, S. Masi, S. Matarrese, D. McCarthy, A. Melchiorri, J.-B. Melin, D. Molinari, A. Monfardini, P. Natoli, M. Negrello, A. Notari, A. Paiella, D. Paoletti, G. Patanchon, M. Piat, G. Pisano, L. Polastri, G. Polenta, A. Pollo, V. Poulin, M. Quartin, M. Remazeilles, M. Roman, J.-A. Rubino-Martin, L. Salvati, A. Tartari, M. Tomasi, D. Tramonte, N. Trappe, T. Trombetti, C. Tucker, J. Valiviita, R. Van de Weijgaert, B. van Tent, V. Vennin, P. Vielva, N. Vittorio, K. Young, M. Zannoni, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Lagrange de Paris, Sorbonne Universités, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Néel (NEEL), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Département de Physique des Particules (ex SPP) (DPP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), CORE, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Sorbonne Université (SU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Challinor, A, Allison, R, Carron, J, Errard, J, Feeney, S, Kitching, T, Lesgourgues, J, Lewis, A, Zubeldía, Í, Achucarro, A, Ade, P, Ashdown, M, Ballardini, M, Banday, A, Banerji, R, Bartlett, J, Bartolo, N, Basak, S, Baumann, D, Bersanelli, M, Bonaldi, A, Bonato, M, Borrill, J, Bouchet, F, Boulanger, F, Brinckmann, T, Bucher, M, Burigana, C, Buzzelli, A, Cai, Z, Calvo, M, Carvalho, C, Castellano, G, Chluba, J, Clesse, S, Colantoni, I, Coppolecchia, A, Crook, M, D'Alessandro, G, de Bernardis, P, de Gasperis, G, Zotti, G, Delabrouille, J, Valentino, E, Diego, J, Fernandez-Cobos, R, Ferraro, S, Finelli, F, Forastieri, F, Galli, S, Genova-Santos, R, Gerbino, M, González-Nuevo, J, Grandis, S, Greenslade, J, Hagstotz, S, Hanany, S, Handley, W, Hernandez-Monteagudo, C, Hervías-Caimapo, C, Hills, M, Hivon, E, Kiiveri, K, Kisner, T, Kunz, M, Kurki-Suonio, H, Lamagna, L, Lasenby, A, Lattanzi, M, Liguori, M, Lindholm, V, López-Caniego, M, Luzzi, G, Maffei, B, Martinez-González, E, Martins, C, Masi, S, Matarrese, S, Mccarthy, D, Melchiorri, A, Melin, J, Molinari, D, Monfardini, A, Natoli, P, Negrello, M, Notari, A, Paiella, A, Paoletti, D, Patanchon, G, Piat, M, Pisano, G, Polastri, L, Polenta, G, Pollo, A, Poulin, V, Quartin, M, Remazeilles, M, Roman, M, Rubino-Martin, J, Salvati, L, Tartari, A, Tomasi, M, Tramonte, D, Trappe, N, Trombetti, T, Tucker, C, Valiviita, J, de Weijgaert, R, Tent, B, Vennin, V, Vielva, P, Vittorio, N, Young, K, Zannoni, M, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Helsinki Institute of Physics, Department of Physics, String Theory (ITFA, IoP, FNWI), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Cryogénie (NEEL - Cryo), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Département de Physique des Particules (ex SPP) (DPhP), and Hélium : du fondamental aux applications (NEEL - HELFA)
- Subjects
deflection ,Cosmic microwave background ,cosmic background radiation: polarization ,astro-ph.CO ,Astrophysics ,ST/N000927/1 ,ST/L000652/1 ,7. Clean energy ,01 natural sciences ,CMBR polarisation, gravitational lensing, inflation, neutrino masses from cosmology ,ART. NO. 023003 ,estimator ,neutrino: mass ,010303 astronomy & astrophysics ,Physics ,FLUCTUATIONS ,GRAVITY-WAVES ,Amplitude ,non-Gaussianity ,galaxy: cluster ,Halo ,gravitational radiation: power spectrum ,Neutrino ,CMBR polarization ,gravitational lensing ,ination ,neutrino masses from cosmology ,Astronomy and Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,CMBR polarisation ,noise ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,B-mode: lens ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,MASS ,NO ,FIS/05 - ASTRONOMIA E ASTROFISICA ,Settore FIS/05 - Astronomia e Astrofisica ,gravitation: lens ,0103 physical sciences ,ddc:530 ,RECONSTRUCTION ,inflation ,Galaxy cluster ,STFC ,halo: mass ,010308 nuclear & particles physics ,Gravitational wave ,gravitational radiation: primordial ,RCUK ,115 Astronomy, Space science ,redshift ,calibration ,Redshift ,Gravitational lens ,CROSS-CORRELATION ,RADIATION ,neutrino: oscillation ,GALAXY CLUSTERS ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,MICROWAVE BACKGROUND POLARIZATION ,MATTER - Abstract
Lensing of the CMB is now a well-developed probe of large-scale clustering over a broad range of redshifts. By exploiting the non-Gaussian imprints of lensing in the polarization of the CMB, the CORE mission can produce a clean map of the lensing deflections over nearly the full-sky. The number of high-S/N modes in this map will exceed current CMB lensing maps by a factor of 40, and the measurement will be sample-variance limited on all scales where linear theory is valid. Here, we summarise this mission product and discuss the science that it will enable. For example, the summed mass of neutrinos will be determined to an accuracy of 17 meV combining CORE lensing and CMB two-point information with contemporaneous BAO measurements, three times smaller than the minimum total mass allowed by neutrino oscillations. In the search for B-mode polarization from primordial gravitational waves with CORE, lens-induced B-modes will dominate over instrument noise, limiting constraints on the gravitational wave power spectrum amplitude. With lensing reconstructed by CORE, one can "delens" the observed polarization internally, reducing the lensing B-mode power by 60%. This improves to 70% by combining lensing and CIB measurements from CORE, reducing the error on the gravitational wave amplitude by 2.5 compared to no delensing (in the null hypothesis). Lensing measurements from CORE will allow calibration of the halo masses of the 40000 galaxy clusters that it will find, with constraints dominated by the clean polarization-based estimators. CORE can accurately remove Galactic emission from CMB maps with its 19 frequency channels. We present initial findings that show that residual Galactic foreground contamination will not be a significant source of bias for lensing power spectrum measurements with CORE. [abridged], 44 pages, 12 figures
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- 2018
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47. CO
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D, Caniani, M, Caivano, R, Pascale, G, Bianco, I M, Mancini, S, Masi, G, Mazzone, M, Firouzian, and D, Rosso
- Abstract
Water resource recovery facilities (WRRFs) contribute to climate change and air pollution, as they are anthropogenic potential sources of direct and indirect emission of greenhouse gases (GHGs). Studies concerning the monitoring and accounting for GHG emissions from WRRFs are of increasing interest. In this study, the floating hood technique for gas collection was coupled with the off-gas method to monitor and apportion nitrous oxide (N
- Published
- 2017
48. Realization of Cold-Electron Bolometers with Ultimate Sensitivity Due to Strong Electron Self-Cooling
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L. S. Kuzmin, V. A. Shamporov, A .A. Gunbina, A. L. Pankratov, A. V. Gordeeva, V. O. Zbrozhek, L. S. Revin, S. Masi, and P. de Bernardis
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Materials science ,business.industry ,Bolometer ,Optical power ,Electron ,Temperature measurement ,law.invention ,Telescope ,law ,Electron temperature ,Optoelectronics ,Photonics ,business ,Electron cooling - Abstract
We have realized an ultimate photon-noise-limited array of cold-electron bolometers (CEBs) for OLIMPO Balloon Telescope. The CEB array demonstrates very effective electron self-cooling of the absorber from 310 mK to 100 mK without optical power load, P0, and from 310 mK to 160 mK with P0= 20 pW at 345 GHz. Due to this effective electron cooling acting as strong electrothermal feedback, the ultimate photon-noise-limited mode of operation is realized in the range of P0 starting from 8 pW and up to P0=20 pW at Tph=330 mK. To our knowledge, there is no analog in the world for bolometers working at electron temperature less than phonon temperature.
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- 2017
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49. SUN-PO004: Nutraceutical Intervention with Berberine, Chlorogenic Acid and Tocotrienols for Menopause-Associated Dyslipidemia: A Pilot, Single-ARM Trial
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Annalisa Turri, Marilisa Caraccia, R. Nappi, Silvia Cappello, Emanuele Cereda, S. Masi, and Riccardo Caccialanza
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Nutrition and Dietetics ,Traditional medicine ,business.industry ,Critical Care and Intensive Care Medicine ,medicine.disease ,Menopause ,chemistry.chemical_compound ,Nutraceutical ,Berberine ,Chlorogenic acid ,chemistry ,Intervention (counseling) ,Medicine ,business ,Dyslipidemia - Published
- 2019
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50. Cooperative Effect of GO and Glucose on PEDOT:PSS for High V OC and Hysteresis-Free Solution-Processed Perovskite Solar Cells
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Andrea Listorti, Silvia Colella, A. Giuri, A. Kovtun, S. Dell-Elce, E. Treossi, S. Masi, A. Rizzo, C. E. Corcione, and A. Liscio
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Materials science ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Free solution ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Hysteresis ,Chemical engineering ,PEDOT:PSS ,Electrochemistry ,0210 nano-technology ,Perovskite (structure) - Published
- 2017
- Full Text
- View/download PDF
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