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2. Measurement of the energy dependence of the e + e − → B B ¯ $$ B\overline{B} $$ , B B ¯ ∗ $$ B{\overline{B}}^{\ast } $$ , and B ∗ B ¯ ∗ $$ {B}^{\ast }{\overline{B}}^{\ast } $$ cross sections at Belle II

Author

The Belle II collaboration, I. Adachi, L. Aggarwal, H. Ahmed, H. Aihara, N. Akopov, A. Aloisio, N. Althubiti, N. Anh Ky, D. M. Asner, H. Atmacan, T. Aushev, V. Aushev, M. Aversano, R. Ayad, V. Babu, H. Bae, S. Bahinipati, P. Bambade, Sw. Banerjee, S. Bansal, M. Barrett, J. Baudot, M. Bauer, A. Baur, A. Beaubien, F. Becherer, J. Becker, P. K. Behera, J. V. Bennett, F. U. Bernlochner, V. Bertacchi, M. Bertemes, E. Bertholet, M. Bessner, S. Bettarini, B. Bhuyan, F. Bianchi, L. Bierwirth, T. Bilka, D. Biswas, A. Bobrov, D. Bodrov, A. Bolz, A. Bondar, J. Borah, A. Boschetti, A. Bozek, M. Bračko, P. Branchini, R. A. Briere, T. E. Browder, A. Budano, S. Bussino, Q. Campagna, M. Campajola, L. Cao, G. Casarosa, C. Cecchi, J. Cerasoli, M.-C. Chang, P. Chang, P. Cheema, B. G. Cheon, K. Chilikin, K. Chirapatpimol, H.-E. Cho, K. Cho, S.-J. Cho, S.-K. Choi, S. Choudhury, J. Cochran, L. Corona, J. X. Cui, S. Das, F. Dattola, E. De La Cruz-Burelo, S. A. De La Motte, G. de Marino, G. De Nardo, M. De Nuccio, G. De Pietro, R. de Sangro, M. Destefanis, S. Dey, R. Dhamija, A. Di Canto, F. Di Capua, J. Dingfelder, Z. Doležal, I. Domínguez Jiménez, T. V. Dong, M. Dorigo, D. Dorner, K. Dort, D. Dossett, S. Dreyer, S. Dubey, K. Dugic, G. Dujany, P. Ecker, M. Eliachevitch, D. Epifanov, P. Feichtinger, T. Ferber, D. Ferlewicz, T. Fillinger, C. Finck, G. Finocchiaro, A. Fodor, F. Forti, A. Frey, B. G. Fulsom, A. Gabrielli, E. Ganiev, M. Garcia-Hernandez, R. Garg, A. Garmash, G. Gaudino, V. Gaur, A. Gaz, A. Gellrich, G. Ghevondyan, D. Ghosh, H. Ghumaryan, G. Giakoustidis, R. Giordano, A. Giri, A. Glazov, B. Gobbo, R. Godang, O. Gogota, P. Goldenzweig, W. Gradl, T. Grammatico, S. Granderath, E. Graziani, D. Greenwald, Z. Gruberová, T. Gu, Y. Guan, K. Gudkova, S. Halder, Y. Han, K. Hara, T. Hara, C. Harris, K. Hayasaka, H. Hayashii, S. Hazra, C. Hearty, M. T. Hedges, A. Heidelbach, I. Heredia de la Cruz, M. Hernández Villanueva, A. Hershenhorn, T. Higuchi, E. C. Hill, M. Hoek, M. Hohmann, P. Horak, C.-L. Hsu, T. Humair, T. Iijima, K. Inami, G. Inguglia, N. Ipsita, A. Ishikawa, S. Ito, R. Itoh, M. Iwasaki, P. Jackson, W. W. Jacobs, E.-J. Jang, Q. P. Ji, S. Jia, Y. Jin, A. Johnson, K. K. Joo, H. Junkerkalefeld, H. Kakuno, M. Kaleta, D. Kalita, A. B. Kaliyar, J. Kandra, K. H. Kang, S. Kang, G. Karyan, T. Kawasaki, F. Keil, C. Ketter, C. Kiesling, C.-H. Kim, D. Y. Kim, K.-H. Kim, Y.-K. Kim, H. Kindo, K. Kinoshita, P. Kodyš, T. Koga, S. Kohani, K. Kojima, T. Konno, A. Korobov, S. Korpar, E. Kovalenko, R. Kowalewski, T. M. G. Kraetzschmar, P. Križan, P. Krokovny, Y. Kulii, T. Kuhr, J. Kumar, M. Kumar, R. Kumar, K. Kumara, T. Kunigo, A. Kuzmin, Y.-J. Kwon, S. Lacaprara, Y.-T. Lai, T. Lam, L. Lanceri, J. S. Lange, M. Laurenza, R. Leboucher, F. R. Le Diberder, M. J. Lee, P. Leitl, P. Leo, D. Levit, P. M. Lewis, C. Li, L. K. Li, S. X. Li, Y. Li, Y. B. Li, J. Libby, Q. Y. Liu, Z. Q. Liu, D. Liventsev, S. Longo, A. Lozar, T. Lueck, C. Lyu, Y. Ma, M. Maggiora, S. P. Maharana, R. Maiti, S. Maity, G. Mancinelli, R. Manfredi, E. Manoni, M. Mantovano, D. Marcantonio, S. Marcello, C. Marinas, L. Martel, C. Martellini, A. Martini, T. Martinov, L. Massaccesi, M. Masuda, T. Matsuda, K. Matsuoka, D. Matvienko, S. K. Maurya, J. A. McKenna, R. Mehta, F. Meier, M. Merola, F. Metzner, M. Milesi, C. Miller, M. Mirra, S. Mitra, K. Miyabayashi, H. Miyake, R. Mizuk, G. B. Mohanty, N. Molina-Gonzalez, S. Mondal, S. Moneta, H.-G. Moser, M. Mrvar, R. Mussa, I. Nakamura, M. Nakao, Y. Nakazawa, A. Narimani Charan, M. Naruki, D. Narwal, Z. Natkaniec, A. Natochii, L. Nayak, M. Nayak, G. Nazaryan, M. Neu, C. Niebuhr, N. K. Nisar, S. Nishida, S. Ogawa, Y. Onishchuk, H. Ono, Y. Onuki, P. Oskin, F. Otani, P. Pakhlov, G. Pakhlova, A. Paladino, A. Panta, E. Paoloni, S. Pardi, K. Parham, H. Park, J. Park, S.-H. Park, B. Paschen, A. Passeri, S. Patra, S. Paul, T. K. Pedlar, I. Peruzzi, R. Peschke, R. Pestotnik, F. Pham, M. Piccolo, L. E. Piilonen, G. Pinna Angioni, P. L. M. Podesta-Lerma, T. Podobnik, S. Pokharel, C. Praz, S. Prell, E. Prencipe, M. T. Prim, S. Privalov, H. Purwar, N. Rad, P. Rados, G. Raeuber, S. Raiz, N. Rauls, K. Ravindran, M. Reif, S. Reiter, M. Remnev, L. Reuter, I. Ripp-Baudot, S. H. Robertson, M. Roehrken, J. M. Roney, A. Rostomyan, N. Rout, G. Russo, D. Sahoo, D. A. Sanders, S. Sandilya, A. Sangal, L. Santelj, Y. Sato, V. Savinov, B. Scavino, S. Schneider, M. Schnepf, C. Schwanda, Y. Seino, A. Selce, K. Senyo, J. Serrano, M. E. Sevior, C. Sfienti, W. Shan, C. Sharma, C. P. Shen, X. D. Shi, T. Shillington, T. Shimasaki, J.-G. Shiu, D. Shtol, B. Shwartz, A. Sibidanov, F. Simon, J. B. Singh, J. Skorupa, K. Smith, R. J. Sobie, M. Sobotzik, A. Soffer, A. Sokolov, E. Solovieva, S. Spataro, B. Spruck, M. Starič, P. Stavroulakis, S. Stefkova, Z. S. Stottler, R. Stroili, J. Strube, Y. Sue, M. Sumihama, K. Sumisawa, W. Sutcliffe, H. Svidras, M. Takahashi, M. Takizawa, U. Tamponi, S. Tanaka, K. Tanida, F. Tenchini, A. Thaller, O. Tittel, R. Tiwary, D. Tonelli, E. Torassa, N. Toutounji, K. Trabelsi, I. Tsaklidis, M. Uchida, I. Ueda, Y. Uematsu, T. Uglov, K. Unger, Y. Unno, K. Uno, S. Uno, P. Urquijo, Y. Ushiroda, S. E. Vahsen, R. van Tonder, G. S. Varner, K. E. Varvell, M. Veronesi, A. Vinokurova, V. S. Vismaya, L. Vitale, V. Vobbilisetti, R. Volpe, B. Wach, M. Wakai, S. Wallner, E. Wang, M.-Z. Wang, X. L. Wang, Z. Wang, A. Warburton, M. Watanabe, S. Watanuki, C. Wessel, E. Won, X. P. Xu, B. D. Yabsley, S. Yamada, W. Yan, S. B. Yang, J. Yelton, J. H. Yin, K. Yoshihara, C. Z. Yuan, L. Zani, F. Zeng, B. Zhang, Y. Zhang, V. Zhilich, J. S. Zhou, Q. D. Zhou, X. Y. Zhou, V. I. Zhukova, and R. Žlebčík

Subjects
e +-e − Experiments, Quarkonium, Spectroscopy, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We report measurements of the e + e − → B B ¯ $$ B\overline{B} $$ , B B ¯ ∗ $$ B{\overline{B}}^{\ast } $$ , and B ∗ B ¯ ∗ $$ {B}^{\ast }{\overline{B}}^{\ast } $$ cross sections at four energies, 10653, 10701, 10746 and 10805 MeV, using data collected by the Belle II experiment. We reconstruct one B meson in a large number of hadronic final states and use its momentum to identify the production process. In the first 2 – 5 MeV above B ∗ B ¯ ∗ $$ {B}^{\ast }{\overline{B}}^{\ast } $$ threshold, the e + e − → B ∗ B ¯ ∗ $$ {B}^{\ast }{\overline{B}}^{\ast } $$ cross section increases rapidly. This may indicate the presence of a pole close to the threshold.

Published
2024
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3. Measurement of branching-fraction ratios and CP asymmetries in B ± → D CP± K ± decays at Belle and Belle II

Author

The Belle and Belle II collaboration, I. Adachi, L. Aggarwal, H. Aihara, N. Akopov, A. Aloisio, N. Anh Ky, D. M. Asner, H. Atmacan, T. Aushev, V. Aushev, M. Aversano, R. Ayad, V. Babu, H. Bae, S. Bahinipati, P. Bambade, Sw. Banerjee, M. Barrett, J. Baudot, M. Bauer, A. Baur, A. Beaubien, F. Becherer, J. Becker, P. K. Behera, K. Belous, J. V. Bennett, F. U. Bernlochner, V. Bertacchi, M. Bertemes, E. Bertholet, M. Bessner, S. Bettarini, B. Bhuyan, F. Bianchi, T. Bilka, D. Biswas, A. Bobrov, D. Bodrov, A. Bolz, A. Bondar, J. Borah, A. Bozek, M. Bračko, P. Branchini, R. A. Briere, T. E. Browder, A. Budano, S. Bussino, M. Campajola, L. Cao, G. Casarosa, C. Cecchi, J. Cerasoli, M.-C. Chang, P. Chang, P. Cheema, V. Chekelian, B. G. Cheon, K. Chilikin, K. Chirapatpimol, H.-E. Cho, K. Cho, S.-K. Choi, Y. Choi, S. Choudhury, J. Cochran, L. Corona, L. M. Cremaldi, T. Czank, S. Das, F. Dattola, E. De La Cruz-Burelo, S. A. De La Motte, G. de Marino, G. De Nardo, M. De Nuccio, G. De Pietro, R. de Sangro, M. Destefanis, S. Dey, A. De Yta-Hernandez, R. Dhamija, A. Di Canto, F. Di Capua, J. Dingfelder, Z. Doležal, I. Domínguez Jiménez, T. V. Dong, M. Dorigo, K. Dort, D. Dossett, S. Dreyer, S. Dubey, G. Dujany, P. Ecker, M. Eliachevitch, P. Feichtinger, T. Ferber, D. Ferlewicz, T. Fillinger, C. Finck, G. Finocchiaro, A. Fodor, F. Forti, A. Frey, B. G. Fulsom, A. Gabrielli, E. Ganiev, M. Garcia-Hernandez, R. Garg, A. Garmash, G. Gaudino, V. Gaur, A. Gaz, A. Gellrich, G. Ghevondyan, D. Ghosh, H. Ghumaryan, G. Giakoustidis, R. Giordano, A. Giri, B. Gobbo, R. Godang, O. Gogota, P. Goldenzweig, W. Gradl, S. Granderath, E. Graziani, D. Greenwald, Z. Gruberová, T. Gu, Y. Guan, K. Gudkova, S. Halder, Y. Han, T. Hara, K. Hayasaka, H. Hayashii, S. Hazra, C. Hearty, M. T. Hedges, A. Heidelbach, I. Heredia de la Cruz, M. Hernández Villanueva, A. Hershenhorn, T. Higuchi, E. C. Hill, M. Hoek, M. Hohmann, P. Horak, W.-S. Hou, C.-L. Hsu, T. Iijima, K. Inami, N. Ipsita, A. Ishikawa, S. Ito, R. Itoh, M. Iwasaki, P. Jackson, W. W. Jacobs, E.-J. Jang, Q. P. Ji, S. Jia, Y. Jin, A. Johnson, H. Junkerkalefeld, H. Kakuno, A. B. Kaliyar, J. Kandra, K. H. Kang, G. Karyan, T. Kawasaki, F. Keil, C. Ketter, C. Kiesling, C.-H. Kim, D. Y. Kim, K.-H. Kim, Y.-K. Kim, H. Kindo, K. Kinoshita, P. Kodyš, T. Koga, S. Kohani, K. Kojima, A. Korobov, S. Korpar, E. Kovalenko, R. Kowalewski, T. M. G. Kraetzschmar, P. Križan, P. Krokovny, T. Kuhr, M. Kumar, R. Kumar, K. Kumara, T. Kunigo, A. Kuzmin, Y.-J. Kwon, S. Lacaprara, Y.-T. Lai, T. Lam, L. Lanceri, J. S. Lange, M. Laurenza, R. Leboucher, F. R. Le Diberder, M. J. Lee, P. Leitl, D. Levit, P. M. Lewis, C. Li, J. Li, L. K. Li, Y. Li, J. Libby, Q. Y. Liu, Z. Q. Liu, D. Liventsev, S. Longo, T. Lueck, T. Luo, C. Lyu, Y. Ma, M. Maggiora, S. P. Maharana, R. Maiti, S. Maity, G. Mancinelli, R. Manfredi, E. Manoni, M. Mantovano, D. Marcantonio, S. Marcello, C. Marinas, L. Martel, C. Martellini, A. Martini, T. Martinov, L. Massaccesi, M. Masuda, T. Matsuda, D. Matvienko, S. K. Maurya, J. A. McKenna, R. Mehta, F. Meier, M. Merola, F. Metzner, M. Milesi, C. Miller, M. Mirra, K. Miyabayashi, R. Mizuk, G. B. Mohanty, N. Molina-Gonzalez, S. Mondal, S. Moneta, H.-G. Moser, M. Mrvar, R. Mussa, I. Nakamura, T. Nakano, Y. Nakazawa, A. Narimani Charan, M. Naruki, Z. Natkaniec, A. Natochii, L. Nayak, G. Nazaryan, N. K. Nisar, S. Nishida, S. Ogawa, H. Ono, Y. Onuki, P. Oskin, F. Otani, P. Pakhlov, G. Pakhlova, A. Paladino, A. Panta, E. Paoloni, S. Pardi, K. Parham, H. Park, S.-H. Park, B. Paschen, A. Passeri, S. Patra, S. Paul, T. K. Pedlar, I. Peruzzi, R. Peschke, R. Pestotnik, F. Pham, M. Piccolo, L. E. Piilonen, P. L. M. Podesta-Lerma, T. Podobnik, S. Pokharel, C. Praz, S. Prell, E. Prencipe, M. T. Prim, H. Purwar, N. Rad, P. Rados, G. Raeuber, S. Raiz, M. Reif, S. Reiter, M. Remnev, I. Ripp-Baudot, G. Rizzo, L. B. Rizzuto, S. H. Robertson, M. Roehrken, J. M. Roney, A. Rostomyan, N. Rout, G. Russo, D. Sahoo, S. Sandilya, A. Sangal, L. Santelj, Y. Sato, V. Savinov, B. Scavino, C. Schmitt, G. Schnell, C. Schwanda, A. J. Schwartz, Y. Seino, A. Selce, K. Senyo, J. Serrano, M. E. Sevior, C. Sfienti, W. Shan, C. Sharma, X. D. Shi, T. Shillington, J.-G. Shiu, D. Shtol, A. Sibidanov, F. Simon, J. B. Singh, J. Skorupa, R. J. Sobie, M. Sobotzik, A. Soffer, A. Sokolov, E. Solovieva, S. Spataro, B. Spruck, M. Starič, P. Stavroulakis, S. Stefkova, Z. S. Stottler, R. Stroili, J. Strube, M. Sumihama, K. Sumisawa, W. Sutcliffe, H. Svidras, M. Takahashi, M. Takizawa, U. Tamponi, K. Tanida, F. Tenchini, A. Thaller, O. Tittel, R. Tiwary, D. Tonelli, E. Torassa, N. Toutounji, K. Trabelsi, I. Tsaklidis, M. Uchida, I. Ueda, S. Uehara, Y. Uematsu, T. Uglov, K. Unger, Y. Unno, K. Uno, S. Uno, P. Urquijo, Y. Ushiroda, S. E. Vahsen, R. van Tonder, G. S. Varner, K. E. Varvell, A. Vinokurova, V. S. Vismaya, L. Vitale, V. Vobbilisetti, R. Volpe, B. Wach, M. Wakai, S. Wallner, D. Wang, E. Wang, M.-Z. Wang, Z. Wang, A. Warburton, M. Watanabe, S. Watanuki, M. Welsch, C. Wessel, X. P. Xu, B. D. Yabsley, S. Yamada, W. Yan, S. B. Yang, J. H. Yin, K. Yoshihara, C. Z. Yuan, L. Zani, Y. Zhang, V. Zhilich, J. S. Zhou, Q. D. Zhou, V. I. Zhukova, and R. Žlebčík

Subjects
B Physics, CKM Angle Gamma, CP Violation, e +-e − Experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We report results from a study of B ± → DK ± decays followed by D decaying to the CP-even final state K + K − and CP-odd final state K S 0 π 0 $$ {K}_S^0{\pi}^0 $$ , where D is an admixture of D 0 and D ¯ 0 $$ {\overline{D}}^0 $$ states. These decays are sensitive to the Cabibbo-Kobayashi-Maskawa unitarity-triangle angle ϕ 3. The results are based on a combined analysis of the final data set of 772 × 106 B B ¯ $$ B\overline{B} $$ pairs collected by the Belle experiment and a data set of 198 × 106 B B ¯ $$ B\overline{B} $$ pairs collected by the Belle II experiment, both in electron-positron collisions at the Υ(4S) resonance. We measure the CP asymmetries to be A $$ \mathcal{A} $$ CP+ = (+12.5 ± 5.8 ± 1.4)% and A $$ \mathcal{A} $$ CP− = (−16.7 ± 5.7 ± 0.6)%, and the ratios of branching fractions to be R $$ \mathcal{R} $$ CP+ = 1.164 ± 0.081 ± 0.036 and R $$ \mathcal{R} $$ CP− = 1.151 ± 0.074 ± 0.019. The first contribution to the uncertainties is statistical, and the second is systematic. The asymmetries A $$ \mathcal{A} $$ CP+ and A $$ \mathcal{A} $$ CP− have similar magnitudes and opposite signs; their difference corresponds to 3.5 standard deviations. From these values we calculate 68.3% confidence intervals of (8.5 ° < ϕ 3 < 16.5 ° ) or (84.5 ° < ϕ 3 < 95.5 ° ) or (163.3 ° < ϕ 3 < 171.5 ° ) and 0.321 < r B < 0.465.

Published
2024
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4. Identification of Shell Colour Pigments in Marine Snails Clanculus pharaonius and C. margaritarius (Trochoidea; Gastropoda).

Author

S T Williams, S Ito, K Wakamatsu, T Goral, N P Edwards, R A Wogelius, T Henkel, L F C de Oliveira, L F Maia, S Strekopytov, T Jeffries, D I Speiser, and J T Marsden

Subjects
Medicine, Science
Abstract

Colour and pattern are key traits with important roles in camouflage, warning and attraction. Ideally, in order to begin to understand the evolution and ecology of colour in nature, it is important to identify and, where possible, fully characterise pigments using biochemical methods. The phylum Mollusca includes some of the most beautiful exemplars of biological pigmentation, with the vivid colours of sea shells particularly prized by collectors and scientists alike. Biochemical studies of molluscan shell colour were fairly common in the last century, but few of these studies have been confirmed using modern methods and very few shell pigments have been fully characterised. Here, we use modern chemical and multi-modal spectroscopic techniques to identify two porphyrin pigments and eumelanin in the shell of marine snails Clanculus pharaonius and C margaritarius. The same porphyrins were also identified in coloured foot tissue of both species. We use high performance liquid chromatography (HPLC) to show definitively that these porphyrins are uroporphyrin I and uroporphyrin III. Evidence from confocal microscopy analyses shows that the distribution of porphyrin pigments corresponds to the striking pink-red of C. pharaonius shells, as well as pink-red dots and lines on the early whorls of C. margaritarius and yellow-brown colour of later whorls. Additional HPLC results suggest that eumelanin is likely responsible for black spots. We refer to the two differently coloured porphyrin pigments as trochopuniceus (pink-red) and trochoxouthos (yellow-brown) in order to distinguish between them. Trochopuniceus and trochoxouthos were not found in the shell of a third species of the same superfamily, Calliostoma zizyphinum, despite its superficially similar colouration, suggesting that this species has different shell pigments. These findings have important implications for the study of colour and pattern in molluscs specifically, but in other taxa more generally, since this study shows that homology of visible colour cannot be assumed without identification of pigments.

Published
2016
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5. Overview of Large Helical Device experiments of basic plasma physics for solving crucial issues in reaching burning plasma conditions

Author

K. Ida, M. Yoshinuma, M. Kobayashi, T. Kobayashi, N. Kenmochi, F. Nespoli, R.M. Magee, F. Warmer, A. Dinklage, A. Matsuyama, R. Sakamoto, T. Nasu, T. Tokuzawa, T. Kinoshita, K. Tanaka, N. Tamura, K. Nagaoka, M. Nishiura, Y. Takemura, K. Ogawa, G. Motojima, T. Oishi, Y. Morishita, J. Varela, W.H.J. Hayashi, M. Markl, H. Bouvain, Y. Liang, M. Leconte, D. Moseev, V.E. Moiseenko, C.G. Albert, I. Allfrey, A. Alonso, F.J. Arellano, N. Ashikawa, A. Azegami, L. Bardoczi, M. van Berkel, M. Beurskens, M.W. Binderbaue, A. Bortolon, S. Brezinsek, R. Bussiahn, A. Cappa, D. Carralero, I.C. Chan, J. Cheng, X. Dai, D.J. Den Hartog, C.P. Dhard, F. Ding, A. Ejiri, S. Ertmer, T. Fornal, K. Fujita, Y. Fujiwara, H. Funaba, L. Garcia, J.M. Garcia-Regana, I. Garcia-Cortés, I.E. Garkusha, D.A. Gates, Y. Ghai, E.P. Gilson, H. Gota, M. Goto, E.M. Green, V. Haak, S. Hamaguchi, K. Hanada, H. Hara, D. Hartmann, Y. Hayashi, T. Henning, C. Hidalgo, J. Hillairet, R. Hutton, T. Ido, H. Igami, K. Ikeda, S. Inagaki, A. Ishizawa, S. Ito, M. Isobe, Y. Isobe, M. Ivkovic, Z. Jiang, J. Jo, S. Kamio, H. Kasahara, D. Kato, Y. Katoh, Y. Kawachi, Y. Kawamoto, G. Kawamura, T. Kawate, Ye.O. Kazakov, V. Klumper, A. Knieps, W.H. Ko, S. Kobayashi, F. Koike, Yu.V. Kovtun, M. Kubkowska, S. Kubo, S.S.H. Lam, A. Langenberg, H. Laqua, S. Lazerson, J. Lestz, B. Li, L. Liao, Z. Lin, R. Lunsford, S. Masuzaki, H. Matsuura, K.J. McCarthy, D. Medina-Roque, O. Mitarai, A. Mollen, C. Moon, Y. Mori, T. Morisaki, S. Morita, K. Mukai, I. Murakami, S. Murakami, T. Murase, C.M. Muscatello, K. Nagasaki, D. Naujoks, H. Nakano, M. Nakata, Y. Narushima, A. Nagy, J.H. Nicolau, T. Nishizawa, S. Nishimoto, H. Nuga, M. Nunami, R. Ochoukov, S. Ohdachi, J. Ongena, M. Osakabe, N.A. Pablant, N. Panadero, B. Peterson, J. de la Riva Villén, J. Romazanov, J. Rosato, M. Rud, S. Sakakibara, H.A. Sakaue, H. Sakai, I. Sakon, M. Salewski, S. Sangaroon, S. Sereda, T. Stange, K. Saito, S. Satake, R. Seki, T. Seki, S. Sharapov, A. Shimizu, T. Shimozuma, G. Shivam, M. Shoji, D.A. Spong, H. Sugama, Z. Sun, C. Suzuki, Y. Suzuki, T. Tajima, E. Takada, H. Takahashi, K. Toi, Y. Tsuchibushi, N. Tsujii, K. Tsumori, T.I. Tsujimurai, G. Ueno, H. Uehara, J.L. Velasco, E. Wang, K.Y. Watanabe, T. Wauter, U. Wenzel, M. Yajima, H. Yamada, I. Yamada, K. Yanagihara, H. Yamaguchi, R. Yanai, R. Yasuhara, M. Yokoyama, Y. Yoshimura, M. Zarnstorff, M. Zhao, G.Q. Zhong, Q. Zhou, S. Ziaei, LHD Experiment Group, and the W7-X Team

Subjects
Large Helical Device, basic plasma physics, burning plasma, wave–particle interaction, ion mixing, turbulence spreading, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Recently, experiments on basic plasma physics issues for solving future problems in fusion energy have been performed on a Large Helical Device. There are several problems to be solved in future devices for fusion energy. Emerging issues in burning plasma are: alpha-channeling (ion heating by alpha particles), turbulence and transport in electron dominant heating helium ash exhaust, reduction of the divertor heat load. To solve these problems, understanding the basic plasma physics of (1) wave–particle interaction through (inverse) Landau damping, (2) characteristics of electron-scale (high- k ) turbulence, (3) ion mixing and the isotope effect, and (4) turbulence spreading and detachment, is necessary. This overview discusses the experimental studies on these issues and turbulent transport in multi-ion plasma and other issues in the appendix.

Published
2024
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6. Suppression of resistive interchange instability by external RMP

Author

S. Ito, K.Y. Watanabe, Y. Takemura, S. Sakakibara, and S. Masamune

Subjects
helical plasma, interchange instability, RMP, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

We experimentally investigate the effect of external resonant magnetic perturbation (RMP) on resistive interchange MHD instability which is typically observed in the Large Helical Device. We apply the m / n = 1/1 external RMP to discharges with the m / n = 1/1 interchange instability. We find that the electron density fluctuation as well as the magnetic field one is clearly reduced without a reduction of the pressure gradient by imposing the external RMP. Moreover, the achieved beta value as well as the beta gradient at the resonant surface is a little improved under certain conditions. Next, we investigate the responses of interchange instability to the external RMP under some different operational conditions. We find that the amplitude of the external RMP to completely suppress the instability with the shielding of the external RMP has a higher correlation with the volume-averaged beta value than other plasma parameters.

Published
2023
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7. Observation site selection for physical model parameter estimation towards process-driven seismic wavefield reconstruction

Author

K Nakai, T Nagata, K Yamada, Y Saito, T Nonomura, M Kano, S Ito, and H Nagao

Subjects
Physics - Geophysics, Signal Processing (eess.SP), Geophysics, Geochemistry and Petrology, FOS: Electrical engineering, electronic engineering, information engineering, FOS: Physical sciences, Electrical Engineering and Systems Science - Signal Processing, Physics::Geophysics, Geophysics (physics.geo-ph)
Abstract

The ``big'' seismic data not only acquired by seismometers but also acquired by vibrometers installed in buildings and infrastructure and accelerometers installed in smartphones will be certainly utilized for seismic research in the near future. Since it is impractical to utilize all the seismic big data in terms of the computational cost, methods which can select observation sites depending on the purpose are indispensable. We propose an observation site selection method for the accurate reconstruction of the seismic wavefield by process-driven approaches. The proposed method selects observation sites suitable for accurately estimating physical model parameters such as subsurface structures and source information to be input into a numerical simulation of the seismic wavefield. The seismic wavefield is reconstructed by the numerical simulation using the parameters estimated based on the observed signals at only observation sites selected by the proposed method. The observation site selection in the proposed method is based on the sensitivity of each observation site candidate to the physical model parameters; the matrix corresponding to the sensitivity is constructed by approximately calculating the derivatives based on the simulations, and then, observation sites are selected by evaluating the quantity of the sensitivity matrix based on the D-optimality criterion proposed in the optimal design of experiments. In the present study, physical knowledge on the sensitivity to the parameters such as seismic velocity, layer thickness, and hypocenter location was obtained by investigating the characteristics of the sensitivity matrix. Furthermore, the effectiveness of the proposed method was shown by verifying the accuracy of seismic wavefield reconstruction using the observation sites selected by the proposed method., Comment: Accepted manuscript for publication in Geophysical Journal International

Published
2023

8. Seismic wavefield reconstruction based on compressed sensing using data-driven reduced-order model

Author

T Nagata, K Nakai, K Yamada, Y Saito, T Nonomura, M Kano, S Ito, and H Nagao

Subjects
Signal Processing (eess.SP), Physics - Geophysics, Geophysics, Geochemistry and Petrology, FOS: Electrical engineering, electronic engineering, information engineering, FOS: Physical sciences, Electrical Engineering and Systems Science - Signal Processing, Geophysics (physics.geo-ph)
Abstract

SUMMARY Reconstruction of the distribution of ground motion due to an earthquake is one of the key technologies for the prediction of seismic damage to infrastructure. Particularly, the immediate reconstruction of the spatially continuous wavefield is valuable for decision-making of disaster response decisions in the initial phase. For a fast and accurate reconstruction, utilization of prior information is essential. In fluid mechanics, full-state recovery, which recovers the full state from sparse observation using a data-driven model reduced-order model, is actively used. In this study, the framework developed in the field of fluid mechanics is applied to seismic wavefield reconstruction. A seismic wavefield reconstruction framework based on compressed sensing using the data-driven reduced-order model (ROM) is proposed and its characteristics are investigated through numerical experiments. The data-driven ROM is generated from the data set of the wavefield using the singular value decomposition. The spatially continuous seismic wavefield is reconstructed from the sparse and discrete observation and the data-driven ROM. The observation sites used for reconstruction are effectively selected by the sensor optimization method for linear inverse problems based on a greedy algorithm. The proposed framework was applied to simulation data of theoretical waveform with the subsurface structure of the horizontally stratified three layers. The validity of the proposed method was confirmed by the reconstruction based on the noise-free observation. Since the ROM of the wavefield is used as prior information, the reconstruction error is reduced to an approximately lower error bound of the present framework, even though the number of sensors used for reconstruction is limited and randomly selected. In addition, the reconstruction error obtained by the proposed framework is much smaller than that obtained by the Gaussian process regression. For the numerical experiment with noise-contaminated observation, the reconstructed wavefield is degraded due to the observation noise, but the reconstruction error obtained by the present framework with all available observation sites is close to a lower error bound, even though the reconstructed wavefield using the Gaussian process regression is fully collapsed. Although the reconstruction error is larger than that obtained using all observation sites, the number of observation sites used for reconstruction can be reduced while minimizing the deterioration and scatter of the reconstructed data by combining it with the sensor optimization method. Hence, a better and more stable reconstruction of the wavefield than randomly selected observation sites can be realized, even if the reconstruction is carried out with a smaller number of observations with observation noise, by combining it with the sensor optimization method.

Published
2022

11. Build-up and dephasing of Floquet–Bloch bands on subcycle timescales

Author

S. Ito, M. Schüler, M. Meierhofer, S. Schlauderer, J. Freudenstein, J. Reimann, D. Afanasiev, K. A. Kokh, O. E. Tereshchenko, J. Güdde, M. A. Sentef, U. Höfer, and R. Huber

Subjects
Multidisciplinary
Abstract

Strong light fields have created opportunities to tailor novel functionalities of solids1,2,3,4,5. Floquet–Bloch states can form under periodic driving of electrons and enable exotic quantum phases6,7,8,9,10,11,12,13,14,15. On subcycle timescales, lightwaves can simultaneously drive intraband currents16,17,18,19,20,21,22,23,24,25,26,27,28,29 and interband transitions18,19,30,31, which enable high-harmonic generation16,18,19,21,22,25,28,29,30 and pave the way towards ultrafast electronics. Yet, the interplay of intraband and interband excitations and their relation to Floquet physics have been key open questions as dynamical aspects of Floquet states have remained elusive. Here we provide this link by visualizing the ultrafast build-up of Floquet–Bloch bands with time-resolved and angle-resolved photoemission spectroscopy. We drive surface states on a topological insulator32,33 with mid-infrared fields—strong enough for high-harmonic generation—and directly monitor the transient band structure with subcycle time resolution. Starting with strong intraband currents, we observe how Floquet sidebands emerge within a single optical cycle; intraband acceleration simultaneously proceeds in multiple sidebands until high-energy electrons scatter into bulk states and dissipation destroys the Floquet bands. Quantum non-equilibrium calculations explain the simultaneous occurrence of Floquet states with intraband and interband dynamics. Our joint experiment and theory study provides a direct time-domain view of Floquet physics and explores the fundamental frontiers of ultrafast band-structure engineering.

Published
2023

14. {Measurement of the \ensuremath{\Lambda}c+ Lifetime}

Author

F. Abudinén, L. Aggarwal, H. Ahmed, J. K. Ahn, H. Aihara, N. Akopov, A. Aloisio, N. Anh Ky, D. M. Asner, H. Atmacan, T. Aushev, V. Aushev, V. Babu, H. Bae, P. Bambade, Sw. Banerjee, S. Bansal, J. Baudot, M. Bauer, A. Baur, A. Beaubien, J. Becker, J. V. Bennett, E. Bernieri, F. U. Bernlochner, V. Bertacchi, M. Bertemes, E. Bertholet, M. Bessner, S. Bettarini, V. Bhardwaj, F. Bianchi, T. Bilka, D. Biswas, D. Bodrov, A. Bolz, G. Bonvicini, A. Bozek, M. Bračko, P. Branchini, R. A. Briere, T. E. Browder, A. Budano, S. Bussino, M. Campajola, L. Cao, G. Casarosa, C. Cecchi, M. -C. Chang, P. Chang, R. Cheaib, P. Cheema, C. Chen, Y. Q. Chen, Y. -T. Chen, B. G. Cheon, K. Chilikin, K. Chirapatpimol, H. -E. Cho, K. Cho, S. -J. Cho, S. -K. Choi, S. Choudhury, D. Cinabro, L. Corona, L. M. Cremaldi, S. Cunliffe, F. Dattola, E. De La Cruz-Burelo, S. A. De La Motte, G. De Nardo, M. De Nuccio, G. De Pietro, R. de Sangro, M. Destefanis, A. De Yta-Hernandez, R. Dhamija, A. Di Canto, F. Di Capua, J. Dingfelder, Z. Doležal, I. Domínguez Jiménez, T. V. Dong, M. Dorigo, K. Dort, D. Dossett, S. Dreyer, G. Dujany, M. Eliachevitch, D. Epifanov, P. Feichtinger, T. Ferber, D. Ferlewicz, T. Fillinger, G. Finocchiaro, K. Flood, A. Fodor, F. Forti, A. Frey, B. G. Fulsom, A. Gabrielli, E. Ganiev, M. Garcia-Hernandez, A. Gaz, A. Gellrich, G. Ghevondyan, R. Giordano, A. Giri, A. Glazov, B. Gobbo, R. Godang, P. Goldenzweig, W. Gradl, S. Granderath, D. Greenwald, T. Gu, Y. Guan, K. Gudkova, J. Guilliams, S. Halder, K. Hara, O. Hartbrich, K. Hayasaka, H. Hayashii, S. Hazra, C. Hearty, I. Heredia de la Cruz, M. Hernández Villanueva, A. Hershenhorn, T. Higuchi, M. Hohmann, T. Humair, T. Iijima, K. Inami, G. Inguglia, N. Ipsita, A. Ishikawa, S. Ito, R. Itoh, M. Iwasaki, Y. Iwasaki, P. Jackson, W. W. Jacobs, D. E. Jaffe, Q. P. Ji, Y. Jin, H. Junkerkalefeld, M. Kaleta, J. Kandra, K. H. Kang, R. Karl, G. Karyan, C. Kiesling, C. -H. Kim, D. Y. Kim, K. -H. Kim, Y. -K. Kim, H. Kindo, K. Kinoshita, P. Kodyš, T. Koga, S. Kohani, K. Kojima, A. Korobov, S. Korpar, E. Kovalenko, R. Kowalewski, T. M. G. Kraetzschmar, P. Križan, P. Krokovny, T. Kuhr, J. Kumar, R. Kumar, K. Kumara, T. Kunigo, Y. -J. Kwon, S. Lacaprara, T. Lam, L. Lanceri, J. S. Lange, M. Laurenza, R. Leboucher, S. C. Lee, P. Leitl, D. Levit, L. K. Li, S. X. Li, Y. B. Li, J. Libby, Z. Liptak, Q. Y. Liu, D. Liventsev, S. Longo, T. Lueck, C. Lyu, M. Maggiora, R. Maiti, S. Maity, R. Manfredi, E. Manoni, S. Marcello, C. Marinas, L. Martel, A. Martini, L. Massaccesi, M. Masuda, K. Matsuoka, D. Matvienko, J. A. McKenna, F. Meier, M. Merola, M. Milesi, C. Miller, K. Miyabayashi, G. B. Mohanty, N. Molina-Gonzalez, S. Moneta, H. Moon, H. -G. Moser, M. Mrvar, R. Mussa, I. Nakamura, M. Nakao, H. Nakayama, A. Narimani Charan, M. Naruki, Z. Natkaniec, A. Natochii, L. Nayak, M. Nayak, G. Nazaryan, C. Niebuhr, N. K. Nisar, S. Nishida, K. Nishimura, H. Ono, P. Oskin, E. R. Oxford, G. Pakhlova, A. Paladino, A. Panta, E. Paoloni, S. Pardi, K. Parham, H. Park, S. -H. Park, A. Passeri, T. K. Pedlar, I. Peruzzi, R. Peschke, R. Pestotnik, F. Pham, L. E. Piilonen, G. Pinna Angioni, P. L. M. Podesta-Lerma, T. Podobnik, S. Pokharel, L. Polat, C. Praz, S. Prell, E. Prencipe, M. T. Prim, H. Purwar, N. Rad, P. Rados, S. Raiz, M. Reif, S. Reiter, I. Ripp-Baudot, G. Rizzo, S. H. Robertson, J. M. Roney, A. Rostomyan, N. Rout, G. Russo, D. A. Sanders, S. Sandilya, A. Sangal, L. Santelj, Y. Sato, V. Savinov, B. Scavino, C. Schwanda, A. J. Schwartz, Y. Seino, A. Selce, K. Senyo, J. Serrano, C. Sfienti, C. P. Shen, T. Shillington, J. -G. Shiu, A. Sibidanov, F. Simon, R. J. Sobie, A. Soffer, A. Sokolov, E. Solovieva, S. Spataro, B. Spruck, M. Starič, S. Stefkova, R. Stroili, J. Strube, M. Sumihama, K. Sumisawa, W. Sutcliffe, S. Y. Suzuki, H. Svidras, M. Takahashi, M. Takizawa, U. Tamponi, S. Tanaka, K. Tanida, H. Tanigawa, N. Taniguchi, F. Tenchini, R. Tiwary, D. Tonelli, E. Torassa, N. Toutounji, K. Trabelsi, M. Uchida, K. Unger, Y. Unno, K. Uno, S. Uno, P. Urquijo, Y. Ushiroda, S. E. Vahsen, R. van Tonder, G. S. Varner, K. E. Varvell, A. Vinokurova, L. Vitale, V. Vobbilisetti, E. Waheed, H. M. Wakeling, E. Wang, M. -Z. Wang, X. L. Wang, A. Warburton, S. Watanuki, M. Welsch, C. Wessel, J. Wiechczynski, H. Windel, E. Won, X. P. Xu, B. D. Yabsley, S. Yamada, S. B. Yang, H. Ye, J. Yelton, J. H. Yin, K. Yoshihara, Y. Yusa, Y. Zhang, V. Zhilich, Q. D. Zhou, V. I. Zhukova, and R. Žlebčík, Abudinén, F., Aggarwal, L., Ahmed, H., Ahn, J. K., Aihara, H., Akopov, N., Aloisio, A., Anh Ky, N., Asner, D. M., Atmacan, H., Aushev, T., Aushev, V., Babu, V., Bae, H., Bambade, P., Banerjee, Sw., Bansal, S., Baudot, J., Bauer, M., Baur, A., Beaubien, A., Becker, J., Bennett, J. V., Bernieri, E., Bernlochner, F. U., Bertacchi, V., Bertemes, M., Bertholet, E., Bessner, M., Bettarini, S., Bhardwaj, V., Bianchi, F., Bilka, T., Biswas, D., Bodrov, D., Bolz, A., Bonvicini, G., Bozek, A., Bračko, M., Branchini, P., Briere, R. A., Browder, T. E., Budano, A., Bussino, S., Campajola, M., Cao, L., Casarosa, G., Cecchi, C., Chang, M. -C., Chang, P., Cheaib, R., Cheema, P., Chen, C., Chen, Y. Q., Chen, Y. -T., Cheon, B. G., Chilikin, K., Chirapatpimol, K., Cho, H. -E., Cho, K., Cho, S. -J., Choi, S. -K., Choudhury, S., Cinabro, D., Corona, L., Cremaldi, L. M., Cunliffe, S., Dattola, F., De La Cruz-Burelo, E., De La Motte, S. A., De Nardo, G., De Nuccio, M., De Pietro, G., de Sangro, R., Destefanis, M., De Yta-Hernandez, A., Dhamija, R., Di Canto, A., Di Capua, F., Dingfelder, J., Doležal, Z., Domínguez Jiménez, I., Dong, T. V., Dorigo, M., Dort, K., Dossett, D., Dreyer, S., Dujany, G., Eliachevitch, M., Epifanov, D., Feichtinger, P., Ferber, T., Ferlewicz, D., Fillinger, T., Finocchiaro, G., Flood, K., Fodor, A., Forti, F., Frey, A., Fulsom, B. G., Gabrielli, A., Ganiev, E., Garcia-Hernandez, M., Gaz, A., Gellrich, A., Ghevondyan, G., Giordano, R., Giri, A., Glazov, A., Gobbo, B., Godang, R., Goldenzweig, P., Gradl, W., Granderath, S., Greenwald, D., Gu, T., Guan, Y., Gudkova, K., Guilliams, J., Halder, S., Hara, K., Hartbrich, O., Hayasaka, K., Hayashii, H., Hazra, S., Hearty, C., Heredia de la Cruz, I., Hernández Villanueva, M., Hershenhorn, A., Higuchi, T., Hohmann, M., Humair, T., Iijima, T., Inami, K., Inguglia, G., Ipsita, N., Ishikawa, A., Ito, S., Itoh, R., Iwasaki, M., Iwasaki, Y., Jackson, P., Jacobs, W. W., Jaffe, D. E., Ji, Q. P., Jin, Y., Junkerkalefeld, H., Kaleta, M., Kandra, J., Kang, K. H., Karl, R., Karyan, G., Kiesling, C., Kim, C. -H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kindo, H., Kinoshita, K., Kodyš, P., Koga, T., Kohani, S., Kojima, K., Korobov, A., Korpar, S., Kovalenko, E., Kowalewski, R., Kraetzschmar, T. M. G., Križan, P., Krokovny, P., Kuhr, T., Kumar, J., Kumar, R., Kumara, K., Kunigo, T., Kwon, Y. -J., Lacaprara, S., Lam, T., Lanceri, L., Lange, J. S., Laurenza, M., Leboucher, R., Lee, S. C., Leitl, P., Levit, D., Li, L. K., Li, S. X., Li, Y. B., Libby, J., Liptak, Z., Liu, Q. Y., Liventsev, D., Longo, S., Lueck, T., Lyu, C., Maggiora, M., Maiti, R., Maity, S., Manfredi, R., Manoni, E., Marcello, S., Marinas, C., Martel, L., Martini, A., Massaccesi, L., Masuda, M., Matsuoka, K., Matvienko, D., Mckenna, J. A., Meier, F., Merola, M., Milesi, M., Miller, C., Miyabayashi, K., Mohanty, G. B., Molina-Gonzalez, N., Moneta, S., Moon, H., Moser, H. -G., Mrvar, M., Mussa, R., Nakamura, I., Nakao, M., Nakayama, H., Narimani Charan, A., Naruki, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nazaryan, G., Niebuhr, C., Nisar, N. K., Nishida, S., Nishimura, K., Ono, H., Oskin, P., Oxford, E. R., Pakhlova, G., Paladino, A., Panta, A., Paoloni, E., Pardi, S., Parham, K., Park, H., Park, S. -H., Passeri, A., Pedlar, T. K., Peruzzi, I., Peschke, R., Pestotnik, R., Pham, F., Piilonen, L. E., Pinna Angioni, G., Podesta-Lerma, P. L. M., Podobnik, T., Pokharel, S., Polat, L., Praz, C., Prell, S., Prencipe, E., Prim, M. T., Purwar, H., Rad, N., Rados, P., Raiz, S., Reif, M., Reiter, S., Ripp-Baudot, I., Rizzo, G., Robertson, S. H., Roney, J. M., Rostomyan, A., Rout, N., Russo, G., Sanders, D. A., Sandilya, S., Sangal, A., Santelj, L., Sato, Y., Savinov, V., Scavino, B., Schwanda, C., Schwartz, A. J., Seino, Y., Selce, A., Senyo, K., Serrano, J., Sfienti, C., Shen, C. P., Shillington, T., Shiu, J. -G., Sibidanov, A., Simon, F., Sobie, R. J., Soffer, A., Sokolov, A., Solovieva, E., Spataro, S., Spruck, B., Starič, M., Stefkova, S., Stroili, R., Strube, J., Sumihama, M., Sumisawa, K., Sutcliffe, W., Suzuki, S. Y., Svidras, H., Takahashi, M., Takizawa, M., Tamponi, U., Tanaka, S., Tanida, K., Tanigawa, H., Taniguchi, N., Tenchini, F., Tiwary, R., Tonelli, D., Torassa, E., Toutounji, N., Trabelsi, K., Uchida, M., Unger, K., Unno, Y., Uno, K., Uno, S., Urquijo, P., Ushiroda, Y., Vahsen, S. E., van Tonder, R., Varner, G. S., Varvell, K. E., Vinokurova, A., Vitale, L., Vobbilisetti, V., Waheed, E., Wakeling, H. M., Wang, E., Wang, M. -Z., Wang, X. L., Warburton, A., Watanuki, S., Welsch, M., Wessel, C., Wiechczynski, J., Windel, H., Won, E., Xu, X. P., Yabsley, B. D., Yamada, S., Yang, S. B., Ye, H., Yelton, J., Yin, J. H., Yoshihara, K., Yusa, Y., Zhang, Y., Zhilich, V., Zhou, Q. D., Zhukova, V. I., and Žlebčík, and R.

Abstract

An absolute measurement of the Λ_{c}^{+} lifetime is reported using Λ_{c}^{+}→pK^{-}π^{+} decays in events reconstructed from data collected by the Belle II experiment at the SuperKEKB asymmetric-energy electron-positron collider. The total integrated luminosity of the data sample, which was collected at center-of-mass energies at or near the ϒ(4S) resonance, is 207.2 fb^{-1}. The result, τ(Λ_{c}^{+})=203.20±0.89±0.77 fs, where the first uncertainty is statistical and the second systematic, is the most precise measurement to date and is consistent with previous determinations.

Published
2023

15. {Measurement of the \ensuremath{\Omega}c0 lifetime at Belle II}

Author

F. Abudinén, I. Adachi, L. Aggarwal, H. Ahmed, H. Aihara, N. Akopov, A. Aloisio, N. Anh Ky, D. M. Asner, T. Aushev, V. Aushev, H. Bae, P. Bambade, Sw. Banerjee, J. Baudot, M. Bauer, A. Beaubien, J. Becker, P. K. Behera, J. V. Bennett, E. Bernieri, F. U. Bernlochner, V. Bertacchi, M. Bertemes, E. Bertholet, M. Bessner, S. Bettarini, B. Bhuyan, F. Bianchi, T. Bilka, D. Biswas, D. Bodrov, A. Bolz, J. Borah, A. Bozek, M. Bračko, P. Branchini, R. A. Briere, T. E. Browder, A. Budano, S. Bussino, M. Campajola, L. Cao, G. Casarosa, C. Cecchi, M. -C. Chang, P. Cheema, V. Chekelian, Y. Q. Chen, K. Chilikin, K. Chirapatpimol, H. -E. Cho, K. Cho, S. -J. Cho, S. -K. Choi, S. Choudhury, D. Cinabro, L. Corona, S. Cunliffe, S. Das, F. Dattola, E. De La Cruz-Burelo, S. A. De La Motte, G. de Marino, G. De Nardo, M. De Nuccio, G. De Pietro, R. de Sangro, M. Destefanis, S. Dey, A. De Yta-Hernandez, R. Dhamija, A. Di Canto, F. Di Capua, J. Dingfelder, Z. Doležal, I. Domínguez Jiménez, T. V. Dong, M. Dorigo, K. Dort, S. Dreyer, S. Dubey, G. Dujany, P. Ecker, M. Eliachevitch, D. Epifanov, P. Feichtinger, T. Ferber, D. Ferlewicz, T. Fillinger, G. Finocchiaro, A. Fodor, F. Forti, B. G. Fulsom, E. Ganiev, V. Gaur, A. Gaz, A. Gellrich, G. Ghevondyan, R. Giordano, A. Giri, A. Glazov, B. Gobbo, R. Godang, P. Goldenzweig, W. Gradl, S. Granderath, E. Graziani, D. Greenwald, T. Gu, Y. Guan, K. Gudkova, J. Guilliams, K. Hayasaka, H. Hayashii, S. Hazra, C. Hearty, I. Heredia de la Cruz, M. Hernández Villanueva, A. Hershenhorn, T. Higuchi, E. C. Hill, H. Hirata, M. Hohmann, C. -L. Hsu, T. Iijima, K. Inami, G. Inguglia, N. Ipsita, A. Ishikawa, S. Ito, R. Itoh, M. Iwasaki, P. Jackson, W. W. Jacobs, D. E. Jaffe, E. -J. Jang, S. Jia, Y. Jin, K. K. Joo, H. Junkerkalefeld, A. B. Kaliyar, K. H. Kang, R. Karl, G. Karyan, C. Kiesling, C. -H. Kim, D. Y. Kim, K. -H. Kim, Y. -K. Kim, H. Kindo, K. Kinoshita, P. Kodyš, T. Koga, S. Kohani, K. Kojima, T. Konno, A. Korobov, S. Korpar, E. Kovalenko, R. Kowalewski, T. M. G. Kraetzschmar, P. Križan, P. Krokovny, J. Kumar, K. Kumara, T. Kunigo, A. Kuzmin, Y. -J. Kwon, S. Lacaprara, T. Lam, L. Lanceri, J. S. Lange, M. Laurenza, K. Lautenbach, R. Leboucher, C. Li, L. K. Li, J. Libby, K. Lieret, Z. Liptak, Q. Y. Liu, D. Liventsev, S. Longo, A. Lozar, T. Lueck, C. Lyu, M. Maggiora, R. Maiti, R. Manfredi, E. Manoni, S. Marcello, C. Marinas, A. Martini, T. Martinov, L. Massaccesi, M. Masuda, S. K. Maurya, J. A. McKenna, F. Meier, M. Merola, F. Metzner, M. Milesi, C. Miller, K. Miyabayashi, R. Mizuk, G. B. Mohanty, N. Molina-Gonzalez, S. Moneta, H. -G. Moser, M. Mrvar, R. Mussa, I. Nakamura, M. Nakao, H. Nakayama, Y. Nakazawa, A. Narimani Charan, M. Naruki, Z. Natkaniec, A. Natochii, L. Nayak, M. Nayak, G. Nazaryan, N. K. Nisar, S. Ogawa, H. Ono, Y. Onuki, E. R. Oxford, A. Paladino, A. Panta, E. Paoloni, S. Pardi, H. Park, S. -H. Park, A. Passeri, S. Paul, T. K. Pedlar, I. Peruzzi, R. Peschke, R. Pestotnik, M. Piccolo, L. E. Piilonen, P. L. M. Podesta-Lerma, T. Podobnik, S. Pokharel, L. Polat, C. Praz, S. Prell, E. Prencipe, M. T. Prim, H. Purwar, N. Rad, P. Rados, S. Raiz, A. Ramirez Morales, M. Reif, S. Reiter, M. Remnev, I. Ripp-Baudot, G. Rizzo, S. H. Robertson, J. M. Roney, A. Rostomyan, N. Rout, G. Russo, D. A. Sanders, S. Sandilya, A. Sangal, Y. Sato, V. Savinov, B. Scavino, J. Schueler, C. Schwanda, A. J. Schwartz, B. Schwenker, Y. Seino, A. Selce, K. Senyo, J. Serrano, M. E. Sevior, C. Sfienti, C. P. Shen, X. D. Shi, T. Shillington, A. Sibidanov, J. B. Singh, J. Skorupa, R. J. Sobie, A. Soffer, E. Solovieva, S. Spataro, B. Spruck, M. Starič, S. Stefkova, Z. S. Stottler, R. Stroili, J. Strube, M. Sumihama, K. Sumisawa, W. Sutcliffe, S. Y. Suzuki, H. Svidras, M. Takizawa, U. Tamponi, K. Tanida, H. Tanigawa, F. Tenchini, A. Thaller, R. Tiwary, D. Tonelli, E. Torassa, N. Toutounji, K. Trabelsi, M. Uchida, I. Ueda, Y. Uematsu, T. Uglov, K. Unger, Y. Unno, K. Uno, S. Uno, Y. Ushiroda, S. E. Vahsen, R. van Tonder, G. S. Varner, K. E. Varvell, A. Vinokurova, L. Vitale, V. Vobbilisetti, H. M. Wakeling, E. Wang, M. -Z. Wang, X. L. Wang, A. Warburton, M. Watanabe, S. Watanuki, M. Welsch, C. Wessel, E. Won, B. D. Yabsley, S. Yamada, W. Yan, S. B. Yang, H. Ye, J. Yelton, J. H. Yin, Y. M. Yook, K. Yoshihara, C. Z. Yuan, L. Zani, Y. Zhang, V. Zhilich, Q. D. Zhou, X. Y. Zhou, V. I. Zhukova, and R. Žlebčík, Abudinén, F., Adachi, I., Aggarwal, L., Ahmed, H., Aihara, H., Akopov, N., Aloisio, A., Anh Ky, N., Asner, D. M., Aushev, T., Aushev, V., Bae, H., Bambade, P., Banerjee, Sw., Baudot, J., Bauer, M., Beaubien, A., Becker, J., Behera, P. K., Bennett, J. V., Bernieri, E., Bernlochner, F. U., Bertacchi, V., Bertemes, M., Bertholet, E., Bessner, M., Bettarini, S., Bhuyan, B., Bianchi, F., Bilka, T., Biswas, D., Bodrov, D., Bolz, A., Borah, J., Bozek, A., Bračko, M., Branchini, P., Briere, R. A., Browder, T. E., Budano, A., Bussino, S., Campajola, M., Cao, L., Casarosa, G., Cecchi, C., Chang, M. -C., Cheema, P., Chekelian, V., Chen, Y. Q., Chilikin, K., Chirapatpimol, K., Cho, H. -E., Cho, K., Cho, S. -J., Choi, S. -K., Choudhury, S., Cinabro, D., Corona, L., Cunliffe, S., Das, S., Dattola, F., De La Cruz-Burelo, E., De La Motte, S. A., de Marino, G., De Nardo, G., De Nuccio, M., De Pietro, G., de Sangro, R., Destefanis, M., Dey, S., De Yta-Hernandez, A., Dhamija, R., Di Canto, A., Di Capua, F., Dingfelder, J., Doležal, Z., Domínguez Jiménez, I., Dong, T. V., Dorigo, M., Dort, K., Dreyer, S., Dubey, S., Dujany, G., Ecker, P., Eliachevitch, M., Epifanov, D., Feichtinger, P., Ferber, T., Ferlewicz, D., Fillinger, T., Finocchiaro, G., Fodor, A., Forti, F., Fulsom, B. G., Ganiev, E., Gaur, V., Gaz, A., Gellrich, A., Ghevondyan, G., Giordano, R., Giri, A., Glazov, A., Gobbo, B., Godang, R., Goldenzweig, P., Gradl, W., Granderath, S., Graziani, E., Greenwald, D., Gu, T., Guan, Y., Gudkova, K., Guilliams, J., Hayasaka, K., Hayashii, H., Hazra, S., Hearty, C., Heredia de la Cruz, I., Hernández Villanueva, M., Hershenhorn, A., Higuchi, T., Hill, E. C., Hirata, H., Hohmann, M., Hsu, C. -L., Iijima, T., Inami, K., Inguglia, G., Ipsita, N., Ishikawa, A., Ito, S., Itoh, R., Iwasaki, M., Jackson, P., Jacobs, W. W., Jaffe, D. E., Jang, E. -J., Jia, S., Jin, Y., Joo, K. K., Junkerkalefeld, H., Kaliyar, A. B., Kang, K. H., Karl, R., Karyan, G., Kiesling, C., Kim, C. -H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kindo, H., Kinoshita, K., Kodyš, P., Koga, T., Kohani, S., Kojima, K., Konno, T., Korobov, A., Korpar, S., Kovalenko, E., Kowalewski, R., Kraetzschmar, T. M. G., Križan, P., Krokovny, P., Kumar, J., Kumara, K., Kunigo, T., Kuzmin, A., Kwon, Y. -J., Lacaprara, S., Lam, T., Lanceri, L., Lange, J. S., Laurenza, M., Lautenbach, K., Leboucher, R., Li, C., Li, L. K., Libby, J., Lieret, K., Liptak, Z., Liu, Q. Y., Liventsev, D., Longo, S., Lozar, A., Lueck, T., Lyu, C., Maggiora, M., Maiti, R., Manfredi, R., Manoni, E., Marcello, S., Marinas, C., Martini, A., Martinov, T., Massaccesi, L., Masuda, M., Maurya, S. K., Mckenna, J. A., Meier, F., Merola, M., Metzner, F., Milesi, M., Miller, C., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Molina-Gonzalez, N., Moneta, S., Moser, H. -G., Mrvar, M., Mussa, R., Nakamura, I., Nakao, M., Nakayama, H., Nakazawa, Y., Narimani Charan, A., Naruki, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nazaryan, G., Nisar, N. K., Ogawa, S., Ono, H., Onuki, Y., Oxford, E. R., Paladino, A., Panta, A., Paoloni, E., Pardi, S., Park, H., Park, S. -H., Passeri, A., Paul, S., Pedlar, T. K., Peruzzi, I., Peschke, R., Pestotnik, R., Piccolo, M., Piilonen, L. E., Podesta-Lerma, P. L. M., Podobnik, T., Pokharel, S., Polat, L., Praz, C., Prell, S., Prencipe, E., Prim, M. T., Purwar, H., Rad, N., Rados, P., Raiz, S., Ramirez Morales, A., Reif, M., Reiter, S., Remnev, M., Ripp-Baudot, I., Rizzo, G., Robertson, S. H., Roney, J. M., Rostomyan, A., Rout, N., Russo, G., Sanders, D. A., Sandilya, S., Sangal, A., Sato, Y., Savinov, V., Scavino, B., Schueler, J., Schwanda, C., Schwartz, A. J., Schwenker, B., Seino, Y., Selce, A., Senyo, K., Serrano, J., Sevior, M. E., Sfienti, C., Shen, C. P., Shi, X. D., Shillington, T., Sibidanov, A., Singh, J. B., Skorupa, J., Sobie, R. J., Soffer, A., Solovieva, E., Spataro, S., Spruck, B., Starič, M., Stefkova, S., Stottler, Z. S., Stroili, R., Strube, J., Sumihama, M., Sumisawa, K., Sutcliffe, W., Suzuki, S. Y., Svidras, H., Takizawa, M., Tamponi, U., Tanida, K., Tanigawa, H., Tenchini, F., Thaller, A., Tiwary, R., Tonelli, D., Torassa, E., Toutounji, N., Trabelsi, K., Uchida, M., Ueda, I., Uematsu, Y., Uglov, T., Unger, K., Unno, Y., Uno, K., Uno, S., Ushiroda, Y., Vahsen, S. E., van Tonder, R., Varner, G. S., Varvell, K. E., Vinokurova, A., Vitale, L., Vobbilisetti, V., Wakeling, H. M., Wang, E., Wang, M. -Z., Wang, X. L., Warburton, A., Watanabe, M., Watanuki, S., Welsch, M., Wessel, C., Won, E., Yabsley, B. D., Yamada, S., Yan, W., Yang, S. B., Ye, H., Yelton, J., Yin, J. H., Yook, Y. M., Yoshihara, K., Yuan, C. Z., Zani, L., Zhang, Y., Zhilich, V., Zhou, Q. D., Zhou, X. Y., Zhukova, V. I., and Žlebčík, and R.

Published
2023

18. Anomalous Hall effect at the spontaneously electron-doped polar surface of PdCoO_{2} ultrathin films

Author

T. Harada, K. Sugawara, K. Fujiwara, M. Kitamura, S. Ito, T. Nojima, K. Horiba, H. Kumigashira, T. Takahashi, T. Sato, and A. Tsukazaki

Subjects
Physics, QC1-999
Abstract

We revealed the electrical transport through surface ferromagnetic states of a nonmagnetic metal PdCoO_{2}. Electronic reconstruction at the Pd-terminated surface of PdCoO_{2} induces Stoner-like ferromagnetic states, which could lead to spin-related phenomena among the highly conducting electrons in PdCoO_{2}. Fabricating a series of nanometer-thick PdCoO_{2} thin films, we detected a surface-magnetization-driven anomalous Hall effect via systematic thickness- and termination-dependent measurements. Besides, we discuss that finite magnetic moments in electron doped CoO_{2} triangular lattices may have given rise to additional unconventional Hall resistance.

Published
2020
Full Text
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25. Cortex-dependent corrections as the tongue reaches for and misses targets

Author

Brendan S. Ito, James Redd, Mei Hong Liu, Brian Kardon, Jesse H. Goldberg, Tejapratap Bollu, and Samuel C. Whitehead

Subjects
Male, 0301 basic medicine, Computer science, Drinking, Article, Mice, 03 medical and health sciences, Neural activity, Deep Learning, 0302 clinical medicine, Tongue, Cortex (anatomy), Reaction Time, Neural control, medicine, Animals, Attention, Multidisciplinary, Motor Cortex, Water, Motor control, Adaptation, Physiological, Biomechanical Phenomena, 030104 developmental biology, medicine.anatomical_structure, Neuroscience, Psychomotor Performance, 030217 neurology & neurosurgery, Motor cortex
Abstract

Precise tongue control is necessary for drinking, eating and vocalizing(1–3). However, because tongue movements are fast and difficult to resolve, neural control of lingual kinematics remains poorly understood. Here we combine kilohertz-frame-rate imaging and a deep-learning-based neural network to resolve 3D tongue kinematics in mice drinking from a water spout. Successful licks required corrective submovements that—similar to online corrections during primate reaches(4–11)—occurred after the tongue missed unseen, distant or displaced targets. Photoinhibition of anterolateral motor cortex impaired corrections, which resulted in hypometric licks that missed the spout. Neural activity in anterolateral motor cortex reflected upcoming, ongoing and past corrective submovements, as well as errors in predicted spout contact. Although less than a tenth of a second in duration, a single mouse lick exhibits the hallmarks of online motor control associated with a primate reach, including cortex-dependent corrections after misses.

Published
2021

28. Search for supernova bursts in Super-Kamiokande IV

Author

M. Mori, K. Abe, Y. Hayato, K. Hiraide, K. Ieki, M. Ikeda, S. Imaizumi, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kashiwagi, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, Y. Nagao, M. Nakahata, Y. Nakano, S. Nakayama, Y. Noguchi, T. Okada, K. Okamoto, A. Orii, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, T. Tomiya, S. Watanabe, T. Yano, S. Yoshida, S. Han, T. Kajita, K. Okumura, T. Tashiro, X. Wang, J. Xia, G. D. Megias, D. Bravo-Berguño, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, S. Zsoldos, B. W. Pointon, F. D. M. Blaszczyk, E. Kearns, J. L. Raaf, J. L. Stone, L. Wan, T. Wester, J. Bian, N. J. Griskevich, W. R. Kropp, S. Locke, M. B. Smy, H. W. Sobel, V. Takhistov, Yankelevich A., J. Hill, J. Y. Kim, I. T. Lim, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, Th. A. Mueller, P. Paganini, B. Quilain, A. D. Santos, T. Ishizuka, T. Nakamura, J. S. Jang, J. G. Learned, L. H. V. Anthony, D. Martin, M. Scott, A. A. Sztuc, Y. Uchida, V. Berardi, M. G. Catanesi, E. Radicioni, N. F. Calabria, L. N. Machado, G. De Rosa, G. Collazuol, F. Iacob, M. Lamoureux, M. Mattiazzi, L. Ludovici, M. Gonin, G. Pronost, Y. Maekawa, Y. Nishimura, C. Fujisawa, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, H. Ozaki, T. Shiozawa, A. T. Suzuki, Y. Takeuchi, S. Yamamoto, Y. Kotsar, Y. Ashida, C. Bronner, J. Feng, S. Hirota, T. Kikawa, T. Nakaya, R. A. Wendell, K. Yasutome, N. McCauley, P. Mehta, K. M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, T. Niwa, M. Tsukada, J. Lagoda, S. M. Lakshmi, P. Mijakowski, J. Zalipska, M. Mandal, Y. S. Prabhu, J. Jiang, C. K. Jung, C. Vilela, M. J. Wilking, C. Yanagisawa, M. Jia, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, H. Kitagawa, Y. Koshio, W. Ma, F. Nakanishi, N. Piplani, S. Sakai, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, F. Nova, T. Boschi, J. Gao, A. Goldsack, T. Katori, F. Di Lodovico, J. Migenda, M. Taani, J. Y. Yang, S. J. Jenkins, M. Malek, J. M. McElwee, O. Stone, M. D. Thiesse, L. F. Thompson, H. Okazawa, S. B. Kim, J. W. Seo, I. Yu, K. Nishijima, M. Koshiba, K. Nakagiri, Y. Nakajima, K. Iwamoto, N. Taniuchi, M. Yokoyama, K. Martens, P. de Perio, M. R. Vagins, M. Kuze, S. Izumiyama, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, T. Kinoshita, R. Matsumoto, K. Ohta, Y. Ommura, N. Shigeta, M. Shinoki, T. Suganuma, K. Yamauchi, J. F. Martin, H. A. Tanaka, T. Towstego, R. Akutsu, V. Gousy-Leblanc, M. Hartz, A. Konaka, N. W. Prouse, S. Chen, B. D. Xu, B. Zhang, M. Posiadala-Zezula, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, J. Walker, Ll. Marti, A. Minamino, G. Pintaudi, R. Sasaki, S. Sano, S. Suzuki, K. Wada, S. Cao, A. ichikawa, K. D. Nakamura, S. Tairafune, K. Choi, Mori, M., Abe, K., Hayato, Y., Hiraide, K., Ieki, K., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakano, Y., Nakayama, S., Noguchi, Y., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Tomiya, T., Watanabe, S., Yano, T., Yoshida, S., Han, S., Kajita, T., Okumura, K., Tashiro, T., Wang, X., Xia, J., Megias, G. D., Bravo-Bergu??o, D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Zsoldos, S., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., A., Yankelevich, Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Mueller, Th. A., Paganini, P., Quilain, B., Santos, A. D., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Maekawa, Y., Nishimura, Y., Fujisawa, C., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Kotsar, Y., Ashida, Y., Bronner, C., Feng, J., Hirota, S., Kikawa, T., Nakaya, T., Wendell, R. A., Yasutome, K., Mccauley, N., Mehta, P., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Niwa, T., Tsukada, M., Lagoda, J., Lakshmi, S. M., Mijakowski, P., Zalipska, J., Mandal, M., Prabhu, Y. S., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Jia, M., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Ma, W., Nakanishi, F., Piplani, N., Sakai, S., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Nova, F., Boschi, T., Gao, J., Goldsack, A., Katori, T., Di Lodovico, F., Migenda, J., Taani, M., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Seo, J. W., Yu, I., Nishijima, K., Koshiba, M., Nakagiri, K., Nakajima, Y., Iwamoto, K., Taniuchi, N., Yokoyama, M., Martens, K., de Perio, P., Vagins, M. R., Kuze, M., Izumiyama, S., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ohta, K., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Hadley, D., Nicholson, M., O???flaherty, M., Richards, B., Ali, A., Jamieson, B., Walker, J., Marti, Ll., Minamino, A., Pintaudi, G., Sasaki, R., Sano, S., Suzuki, S., Wada, K., Cao, S., Ichikawa, A., Nakamura, K. D., Tairafune, S., and Choi, K.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, High Energy Physics - Experiment, Supernova neutrinos, High Energy Physics - Experiment (hep-ex), Space and Planetary Science, Core-collapse supernovae Supernova neutrinos Particle astrophysics, Core-collapse supernovae, Particle astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics
Abstract

Super-Kamiokande has been searching for neutrino bursts characteristic of core-collapse supernovae continuously, in real time, since the start of operations in 1996. The present work focuses on detecting more distant supernovae whose event rate may be too small to trigger in real time, but may be identified using an offline approach. The analysis of data collected from 2008 to 2018 found no evidence of distant supernovae bursts. This establishes an upper limit of 0.29 yr−1 on the rate of core-collapse supernovae out to 100 kpc at 90% C.L. For supernovae that fail to explode and collapse directly to black holes the limit reaches to 300 kpc.

Published
2022

32. Reactions of five-membered zirconacycloalkynes and zirconacycloallenes with Cp2Zr(H)Cl; formal hydrogenation by metal hydrides

Author

S. Ito, Sayaka Ban, Ayari Mochizuki, and Noriyuki Suzuki

Subjects
Zirconium, Hydride, Negishi coupling, chemistry.chemical_element, Medicinal chemistry, Inorganic Chemistry, Metal, chemistry.chemical_compound, chemistry, Hydrogenolysis, Reagent, visual_art, visual_art.visual_art_medium, Protonolysis, Nonane
Abstract

Reactions of five-membered zirconacycloalkynes and zirconacyloallenes (1-zirconacyclopent-3-ynes and 1-zirconacyclopenta-2,3-dienes) with an excess of Cp2Zr(H)Cl, known as the Schwartz reagent, were studied. Both reactions gave five-membered zirconacycloalkenes, 1-zirconacyclopent-3-enes without subsequent work-up such as protonolysis and hydrogenolysis. The product was identical to the zirconocene-diene complex that was prepared from Cp2Zr(n-Bu)2 (Negishi reagent) and the corresponding 1,4-disubstituted 1,3-dienes. These results indicate that formal hydrogenation by metal hydride took place. The use of diisobutylaluminum hydride or 9-borabicyclo[3.3.1]nonane also gave the same product, albeit in lower yields. The reactions starting from deuterated compounds suggested that double hydrozirconation followed by elimination of a dinuclear zirconium complex resulted in the hydrogenated products.

Published
2021

33. First gadolinium loading to Super-Kamiokande

Author

K. Abe, C. Bronner, Y. Hayato, K. Hiraide, M. Ikeda, S. Imaizumi, J. Kameda, Y. Kanemura, Y. Kataoka, S. Miki, M. Miura, S. Moriyama, Y. Nagao, M. Nakahata, S. Nakayama, T. Okada, K. Okamoto, A. Orii, G. Pronost, H. Sekiya, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Watanabe, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, J. Xia, G.D. Megias, D. Bravo-Berguño, L. Labarga, Ll. Marti, B. Zaldivar, B.W. Pointon, F.d.M. Blaszczyk, E. Kearns, J.L. Raaf, J.L. Stone, L. Wan, T. Wester, J. Bian, N.J. Griskevich, W.R. Kropp, S. Locke, S. Mine, M.B. Smy, H.W. Sobel, V. Takhistov, J. Hill, J.Y. Kim, I.T. Lim, R.G. Park, B. Bodur, K. Scholberg, C.W. Walter, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, M. Gonin, Th.A. Mueller, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J.S. Jang, J.G. Learned, L.H.V. Anthony, D. Martin, M. Scott, A.A. Sztuc, Y. Uchida, S. Cao, V. Berardi, M.G. Catanesi, E. Radicioni, N.F. Calabria, L.N. Machado, G. De Rosa, G. Collazuol, F. Iacob, M. Lamoureux, M. Mattiazzi, N. Ospina, L. Ludovici, Y. Maekawa, Y. Nishimura, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, T. Boschi, J. Gao, F. Di Lodovico, J. Migenda, M. Taani, S. Zsoldos, Y. Kotsar, Y. Nakano, H. Ozaki, T. Shiozawa, A.T. Suzuki, Y. Takeuchi, S. Yamamoto, A. Ali, Y. Ashida, J. Feng, S. Hirota, T. Kikawa, M. Mori, T. Nakaya, R.A. Wendell, K. Yasutome, P. Fernandez, N. McCauley, P. Mehta, K.M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, T. Niwa, K. Sato, M. Tsukada, J. Lagoda, S.M. Lakshmi, P. Mijakowski, J. Zalipska, J. Jiang, C.K. Jung, C. Vilela, M.J. Wilking, C. Yanagisawa, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, F. Kitagawa, Y. Koshio, W. Ma, N. Piplani, S. Sakai, G. Barr, D. Barrow, L. Cook, A. Goldsack, S. Samani, D. Wark, F. Nova, J.Y. Yang, S.J. Jenkins, M. Malek, J.M. McElwee, O. Stone, M.D. Thiesse, L.F. Thompson, H. Okazawa, S.B. Kim, J.W. Seo, I. Yu, A.K. Ichikawa, K. Nishijima, M. Koshiba, K. Iwamoto, Y. Nakajima, N. Ogawa, M. Yokoyama, K. Martens, M.R. Vagins, M. Kuze, S. Izumiyama, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, T. Kinoshita, R. Matsumoto, K. Ohta, M. Shinoki, T. Suganuma, J.F. Martin, H.A. Tanaka, T. Towstego, R. Akutsu, M. Hartz, A. Konaka, P. de Perio, N.W. Prouse, S. Chen, B.D. Xu, M. Posiadala-Zezula, D. Hadley, M. O’Flaherty, B. Richards, B. Jamieson, J. Walker, A. Minamino, G. Pintaudi, S. Sano, R. Sasaki, Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kataoka, Y., Miki, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Pronost, G., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Xia, J., Megias, G. D., Bravo-Berguno, D., Labarga, L., Marti, L., Zaldivar, B., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Mine, S., Smy, M. B., Sobel, H. W., Takhistov, V., Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., Hedri, S. E., Giampaolo, A., Gonin, M., Mueller, T. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Cao, S., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ospina, N., Ludovici, L., Maekawa, Y., Nishimura, Y., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Gao, J., Di Lodovico, F., Migenda, J., Taani, M., Zsoldos, S., Kotsar, Y., Nakano, Y., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Feng, J., Hirota, S., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Niwa, T., Sato, K., Tsukada, M., Lagoda, J., Lakshmi, S. M., Mijakowski, P., Zalipska, J., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kitagawa, F., Koshio, Y., Ma, W., Piplani, N., Sakai, S., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Wark, D., Nova, F., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Seo, J. W., Yu, I., Ichikawa, A. K., Nishijima, K., Koshiba, M., Iwamoto, K., Nakajima, Y., Ogawa, N., Yokoyama, M., Martens, K., Vagins, M. R., Kuze, M., Izumiyama, S., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ohta, K., Shinoki, M., Suganuma, T., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., de Perio, P., Prouse, N. W., Chen, S., Xu, B. D., Posiadala-Zezula, M., Hadley, D., O'Flaherty, M., Richards, B., Jamieson, B., Walker, J., Minamino, A., Pintaudi, G., Sano, S., and Sasaki, R.

Subjects
Nuclear and High Energy Physics, Gadolinium Neutrino Neutron Water Cherenkov detector, Physics - Instrumentation and Detectors, 010308 nuclear & particles physics, FOS: Physical sciences, Gadolinium, Neutron, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, Water Cherenkov detector, 0103 physical sciences, Neutrino, 010306 general physics, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

In order to improve Super-Kamiokande's neutron detection efficiency and to thereby increase its sensitivity to the diffuse supernova neutrino background flux, 13 tons of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ (gadolinium sulfate octahydrate) was dissolved into the detector's otherwise ultrapure water from July 14 to August 17, 2020, marking the start of the SK-Gd phase of operations. During the loading, water was continuously recirculated at a rate of 60 m$^3$/h, extracting water from the top of the detector and mixing it with concentrated $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ solution to create a 0.02% solution of the Gd compound before injecting it into the bottom of the detector. A clear boundary between the Gd-loaded and pure water was maintained through the loading, enabling monitoring of the loading itself and the spatial uniformity of the Gd concentration over the 35 days it took to reach the top of the detector. During the subsequent commissioning the recirculation rate was increased to 120 m$^3$/h, resulting in a constant and uniform distribution of Gd throughout the detector and water transparency equivalent to that of previous pure-water operation periods. Using an Am-Be neutron calibration source the mean neutron capture time was measured to be $115\pm1$ $\mu$s, which corresponds to a Gd concentration of $111\pm2$ ppm, as expected for this level of Gd loading. This paper describes changes made to the water circulation system for this detector upgrade, the Gd loading procedure, detector commissioning, and the first neutron calibration measurements in SK-Gd., Comment: 37 pages, 19 Figures, Accepted for publication in Nucl. Instrum. Meth. A

Published
2022

34. Bacterial meningitis after incomplete retrograde obliteration for duodenal varices with encephalopathy: A case report

Author

S. Ito and F. Chikamori

Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine, Nonalcoholic steatohepatitis, medicine.medical_specialty, lcsh:R895-920, Bacterial meningitis, Encephalopathy, Duodenal varices, Coil migration, Gastroenterology, Retrograde obliteration, Internal medicine, Interventional Radiology, medicine, Radiology, Nuclear Medicine and imaging, Vein, Hepatic encephalopathy, medicine.diagnostic_test, business.industry, medicine.disease, High fever, Endoscopy, medicine.anatomical_structure, business
Abstract

We report a case of bacterial meningitis in a 72-year-old female with nonalcoholic steatohepatitis who underwent incomplete retrograde obliteration for duodenal varices with encephalopathy. Two months after incomplete retrograde obliteration, she became febrile, drowsy, and was transported to hospital. Her serum ammonia level was normal. Endoscopy revealed that previously embolized coil was partially migrated into the duodenal lumen. Cerebrospinal fluid examination confirmed the diagnosis of bacterial meningitis. She was treated with intravenous antibiotics. As there was a risk of bleeding, trans-ileocolic vein obliteration of duodenal varices was attempted. The patient slowly recovered and was discharged. This case indicated two problems could occur by coil migration after incomplete retrograde obliteration for duodenal varices with encephalopathy. One was bacterial meningitis and the other was risk of bleeding from duodenal varices. We conclude that cerebrospinal fluid examination is recommended for patients with high fever and abnormal mental status after incomplete retrograde obliteration, and immediate complete obliteration should be attempted for a risk of bleeding.

Published
2020

35. Cumulative incidence of femoral localized periosteal thickening (beaking) preceding atypical femoral fractures in patients with rheumatoid arthritis

Author

Tadahiro Kuroda, Junichiro James Kazama, Takeshi Nakatsue, Youichi Kurosawa, Ayako Wakamatsu, Naoto Endo, H. Ishikawa, Hiroe Sato, Eriko Hasegawa, Naoki Kondo, S. Ito, Yoshiki Suzuki, Daisuke Kobayashi, Chinatsu Takai, A. Abe, and Ichiei Narita

Subjects
medicine.medical_specialty, Stress fractures, Bone Density Conservation Agents, Diphosphonates, business.industry, Incidence, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Bisphosphonate, medicine.disease, Gastroenterology, Rheumatology, Arthritis, Rheumatoid, Internal medicine, Rheumatoid arthritis, Orthopedic surgery, medicine, Prednisolone, Humans, Cumulative incidence, Femur, Risk factor, business, Femoral Fractures, medicine.drug
Abstract

The incidence of localized periosteal thickening (LPT, also termed beaking) of the lateral cortex that often precedes an atypical femoral fracture (AFF) was not high in patients with rheumatoid arthritis (RA) but incomplete AFFs developed in two patients. Higher-dose prednisolone was a significant risk factor for LPT in patients with RA. Atypical femoral fractures (AFFs) are stress fractures; bisphosphonate (BP) use is a major risk factor for the development of such fractures. Localized periosteal thickening (LPT, also termed beaking) of the lateral cortex often precedes a complete or incomplete AFF. We evaluated the incidence of latent LPT in patients with rheumatoid arthritis (RA), to evaluate LPT progression, and to define LPT risk factors. A total of 254 patients with RA were included; all underwent annual X-ray evaluation, dual-energy X-ray absorptiometry, and analyses of serum and bone metabolic markers for 2–3 years. LPT of the lateral cortex was sought in femoral X-rays. The incidence of LPT was 2.4% (6/254). Among patients on both BP and prednisolone (PSL) at enrollment, the incidence was 2.3% (3/131). Two femurs of two patients with LPT developed incomplete AFFs; LPT was extensive and associated with endosteal thickening. One patient had been on BP and PSL and microscopic polyangiitis was comorbidity. The other was on a selective estrogen receptor modulator and PSL. A daily PSL dose >5 mg (OR 11.4; 95%CI 2.15–60.2; p = 0.004) and higher-dose methotrexate (OR 1.22; 95%CI 1.01–1.49; p = 0.043) were significant risk factors for LPT. The incidence of latent LPT was not high (2.4%) but incomplete AFFs developed in two RA patients. Higher-dose PSL because of a comorbid disease requiring glucocorticoid treatment other than RA or refractory RA were risk factors for LPT; X-ray screening for latent LPT would usefully prevent complete AFFs.

Published
2020

36. Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways

Author

Takeshi K. Matsui, Eiichiro Mori, Genro Kashino, Atsuhisa Kajihara, Yoshihiko M. Sakaguchi, Tadaaki Kirita, Sotaro Kikuchi, Soichiro S. Ito, Masatoshi Hasegawa, Shinko Kobashigawa, Fumika Kitayoshi, Hitoki Nanaura, Kazuma Sugie, Mari Nakanishi, Masaya Matsubayashi, Shigehiro Tamaki, Akihisa Takahashi, and Yosuke Nakagawa

Subjects
0301 basic medicine, DNA End-Joining Repair, Ultraviolet Rays, DNA repair, DNA damage, Ataxia Telangiectasia Mutated Proteins, Biochemistry, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, Humans, Protein Kinase Inhibitors, Molecular Biology, 030102 biochemistry & molecular biology, Chemistry, Kinase, Autophosphorylation, DNA replication, Recombinational DNA Repair, Cell Biology, Cell cycle, Neoplasm Proteins, Cell biology, Non-homologous end joining, 030104 developmental biology, Drug Resistance, Neoplasm, Fluorouracil, Homologous recombination
Abstract

The anticancer agent 5-fluorouracil (5-FU) is cytotoxic and often used to treat various cancers. 5-FU is thought to inhibit the enzyme thymidylate synthase, which plays a role in nucleotide synthesis and has been found to induce single- and double-strand DNA breaks. ATR Ser/Thr kinase (ATR) is a principal kinase in the DNA damage response and is activated in response to UV– and chemotherapeutic drug–induced DNA replication stress, but its role in cellular responses to 5-FU is unclear. In this study, we examined the effect of ATR inhibition on 5-FU sensitivity of mammalian cells. Using immunoblotting, we found that 5-FU treatment dose-dependently induced the phosphorylation of ATR at the autophosphorylation site Thr-1989 and thereby activated its kinase. Administration of 5-FU with a specific ATR inhibitor remarkably decreased cell survival, compared with 5-FU treatment combined with other major DNA repair kinase inhibitors. Of note, the ATR inhibition enhanced induction of DNA double-strand breaks and apoptosis in 5-FU–treated cells. Using gene expression analysis, we found that 5-FU induced the activation of the intra-S cell-cycle checkpoint. Cells lacking BRCA2 were sensitive to 5-FU in the presence of ATR inhibitor. Moreover, ATR inhibition enhanced the efficacy of the 5-FU treatment, independently of the nonhomologous end-joining and homologous recombination repair pathways. These findings suggest that ATR could be a potential therapeutic target in 5-FU–based chemotherapy.

Published
2020

37. Severe Degenerative Changes in Cryptorchid Testes in Japanese Black Cattle

Author

Angeline Ping Ping Teh, Takeshi Osawa, Uda Zahli Izzati, Ohnmar Myint, Shidow Torisu, Yuichi Hidaka, Naoyuki Fuke, Go Kitahara, Yasuyuki Kaneko, Ryoji Yamaguchi, Hiroyuki Sato, Nguyen Van Diep, Takuya Hirai, and S. Ito

Subjects
Anti-Mullerian Hormone, Male, Pathology, medicine.medical_specialty, 040301 veterinary sciences, Cattle Diseases, Inflammation, Enteroendocrine cell, 0403 veterinary science, Cryptorchidism, Testis, medicine, Animals, Gonadal Dysgenesis, 46,XY, General Veterinary, business.industry, 0402 animal and dairy science, 04 agricultural and veterinary sciences, Seminiferous Tubules, Immunohistochemistry, 040201 dairy & animal science, Testicular degeneration, Vascular Disorder, Cattle, medicine.symptom, business, Spermatogenesis, TESTICULAR HYPOPLASIA, Hormone
Abstract

This is a histopathologic and endocrinologic study of 6 calves diagnosed with cryptorchidism. Cases 1–3 were diagnosed as resembling testicular regression syndrome. In cases 1 and 2, the extracted tissue was a small, firm, gray-white mass, and there was lack of obvious testicular tissue in case 3. Histopathologically, the excised tissue in cases 1–3 was a fibrotic testicular remnant with inflammation, mineralization, hemosiderin-laden macrophages or lipofuscin-laden macrophages, and lack of germ cells and interstitial endocrine cells. These findings were compared with cases 4–6, which were diagnosed as testicular hypoplasia due to cryptorchidism. These cases had small but otherwise grossly unremarkable intra-abdominal testicular tissue and histologically had a few germ cells and sustentacular cells with arrested spermatogenesis and an increase in interstitial endocrine cells. Cases 1–3 had more severe degenerative changes compared with cases 4–6. In case 2, the average diameter of the seminiferous tubules was much smaller than in cases 4–6, and there were few tubule cross sections. Anti-Müllerian hormone (214 pg/ml) was detected in the plasma of case 2. Based on the macroscopic and histopathologic findings as well as endocrinologic profiles, the testicular degeneration in cases 1–3 was considered similar to that of testicular regression syndrome. In this condition, it is thought that a normally developing intra-abdominal testis undergoes degeneration due to heat or a vascular disorder such as torsion.

Published
2020

39. Non-integer High-Harmonic Generation from a Topological Insulator Surface

Author

M. Meierhofer, C. P. Schmid, L. Weigl, P. Grössing, V. Junk, C. Gorini, S. Schlauderer, S. Ito, N. Hofmann, D. Afanasiev, J. Crewse, K. A. Kokh, O. E. Tereshchenko, J. Güdde, F. Evers, J. Wilhelm, K. Richter, U. Höfer, and R. Huber

Abstract

We selectively explore bulk-versus-surface high-harmonic generation in a topological insulator by tuning the driving frequency. Ballistic acceleration of Dirac currents manifests in continuously tunable non-integer harmonic orders and unique polarization fingerprints of the topological invariant.

Published
2022

40. Neutron tagging following atmospheric neutrino events in a water Cherenkov detector

Author

K. Abe, Y. Haga, Y. Hayato, K. Hiraide, K. Ieki, M. Ikeda, S. Imaizumi, K. Iyogi, J. Kameda, Y. Kanemura, Y. Kataoka, Y. Kato, Y. Kishimoto, S. Miki, S. Mine, M. Miura, T. Mochizuki, S. Moriyama, Y. Nagao, M. Nakahata, T. Nakajima, Y. Nakano, S. Nakayama, T. Okada, K. Okamoto, A. Orii, K. Sato, H. Sekiya, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Tasaka, T. Tomura, K. Ueno, S. Watanabe, T. Yano, T. Yokozawa, S. Han, T. Irvine, T. Kajita, I. Kametani, K. Kaneyuki, K.P. Lee, T. McLachlan, K. Okumura, E. Richard, T. Tashiro, R. Wang, J. Xia, G.D. Megias, D. Bravo-Berguño, L. Labarga, B. Zaldivar, M. Goldhaber, F.d.M. Blaszczyk, J. Gustafson, C. Kachulis, E. Kearns, J.L. Raaf, J.L. Stone, L.R. Sulak, S. Sussman, L. Wan, T. Wester, B.W. Pointon, J. Bian, G. Carminati, M. Elnimr, N.J. Griskevich, W.R. Kropp, S. Locke, A. Renshaw, M.B. Smy, H.W. Sobel, V. Takhistov, P. Weatherly, K.S. Ganezer, B.L. Hartfiel, J. Hill, W.E. Keig, N. Hong, J.Y. Kim, I.T. Lim, R.G. Park, T. Akiri, B. Bodur, A. Himmel, Z. Li, E. O'Sullivan, K. Scholberg, C.W. Walter, T. Wongjirad, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, J. Imber, Th.A. Mueller, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J.S. Jang, K. Choi, J.G. Learned, S. Matsuno, S.N. Smith, J. Amey, L.H.V. Anthony, R.P. Litchfield, W.Y. Ma, D. Marin, A.A. Sztuc, Y. Uchida, M.O. Wascko, V. Berardi, M.G. Catanesi, R.A. Intonti, E. Radicioni, N.F. Calabria, G. De Rosa, L.N. Machado, G. Collazuol, F. Iacob, M. Lamoureux, N. Ospina, L. Ludovici, M. Gonin, G. Pronost, Y. Maekawa, Y. Nishimura, S. Cao, M. Friend, T. Hasegawa, T. Ishida, T. Ishii, M. Jakkapu, T. Kobayashi, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, T. Boschi, F. Di Lodovico, J. Migenda, S. Molina Sedgwick, M. Taani, S. Zsoldos, K.E. Abe, M. Hasegawa, Y. Isobe, Y. Kotsar, H. Miyabe, H. Ozaki, T. Shiozawa, T. Sugimoto, A.T. Suzuki, Y. Takeuchi, S. Yamamoto, A. Ali, Y. Ashida, C. Bronner, J. Feng, T. Hayashino, T. Hiraki, S. Hirota, K. Huang, M. Jiang, T. Kikawa, M. Mori, A. Murakami, KE. Nakamura, T. Nakaya, N.D. Patel, K. Suzuki, S. Takahashi, K. Tateishi, R.A. Wendell, K. Yasutome, P. Fernandez, N. McCauley, P. Mehta, A. Pritchard, K.M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, G. Mitsuka, M. Murase, F. Muto, T. Niwa, T. Suzuki, M. Tsukada, K. Frankiewicz, P. Mijakowski, J. Hignight, J. Jiang, C.K. Jung, X. Li, J.L. Palomino, G. Santucci, C. Vilela, M.J. Wilking, C. Yanagisawa, D. Fukuda, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, T. Kayano, A. Kibayashi, H. Kitagawa, Y. Koshio, W. Ma, T. Mori, H. Nagata, N. Piplani, S. Sakai, M. Sakuda, Y. Takahira, C. Xu, R. Yamaguchi, Y. Kuno, G. Barr, D. Barrow, L. Cook, A. Goldsack, S. Samani, C. Simpson, D. Wark, F. Nova, R. Tacik, J.Y. Yang, A. Cole, S.J. Jenkins, M. Malek, J.M. McElwee, O. Stone, M.D. Thiesse, L.F. Thompson, H. Okazawa, Y. Choi, S.B. Kim, I. Yu, A.K. Ichikawa, K. Ito, K. Nishijima, R.G. Calland, P. de Perio, K. Martens, M. Murdoch, M.R. Vagins, M. Koshiba, Y. Totsuka, K. Iwamoto, Y. Nakajima, N. Ogawa, Y. Suda, M. Yokoyama, D. Hamabe, S. Izumiyama, M. Kuze, Y. Okajima, M. Tanaka, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, R. Matsumoto, K. Ohta, M. Shinoki, J.F. Martin, C.M. Nantais, H.A. Tanaka, T. Towstego, R. Akutsu, M. Hartz, A. Konaka, N.W. Prouse, S. Chen, B.D. Xu, Y. Zhang, S. Berkman, S. Tobayama, K. Connolly, R.J. Wilkes, M. Posiadala-Zezula, D. Hadley, B. Richards, B. Jamieson, J. Walker, Ll. Marti, A. Minamino, G. Pintaudi, S. Sano, R. Sasaki, Abe, K., Haga, Y., Hayato, Y., Hiraide, K., Ieki, K., Ikeda, M., Imaizumi, S., Iyogi, K., Kameda, J., Kanemura, Y., Kataoka, Y., Kato, Y., Kishimoto, Y., Miki, S., Mine, S., Miura, M., Mochizuki, T., Moriyama, S., Nagao, Y., Nakahata, M., Nakajima, T., Nakano, Y., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Tasaka, S., Tomura, T., Ueno, K., Watanabe, S., Yano, T., Yokozawa, T., Han, S., Irvine, T., Kajita, T., Kametani, I., Kaneyuki, K., Lee, K. P., Mclachlan, T., Okumura, K., Richard, E., Tashiro, T., Wang, R., Xia, J., Megias, G. D., Bravo-Bergu??o, D., Labarga, L., Zaldivar, B., Goldhaber, M., Blaszczyk, F. d. M., Gustafson, J., Kachulis, C., Kearns, E., Raaf, J. L., Stone, J. L., Sulak, L. R., Sussman, S., Wan, L., Wester, T., Pointon, B. W., Bian, J., Carminati, G., Elnimr, M., Griskevich, N. J., Kropp, W. R., Locke, S., Renshaw, A., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Ganezer, K. S., Hartfiel, B. L., Hill, J., Keig, W. E., Hong, N., Kim, J. Y., Lim, I. T., Park, R. G., Akiri, T., Bodur, B., Himmel, A., Li, Z., O'Sullivan, E., Scholberg, K., Walter, C. W., Wongjirad, T., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Imber, J., Mueller, Th. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Choi, K., Learned, J. G., Matsuno, S., Smith, S. N., Amey, J., Anthony, L. H. V., Litchfield, R. P., Ma, W. Y., Marin, D., Sztuc, A. A., Uchida, Y., Wascko, M. O., Berardi, V., Catanesi, M. G., Intonti, R. A., Radicioni, E., Calabria, N. F., De Rosa, G., Nascimento Machado, L., Collazuol, G., Iacob, F., Lamoureux, M., Ospina, N., Ludovici, L., Gonin, M., Pronost, G., Maekawa, Y., Nishimura, Y., Cao, S., Friend, M., Hasegawa, T., Ishida, T., Ishii, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Di Lodovico, F., Migenda, J., Molina Sedgwick, S., Taani, M., Zsoldos, S., Abe, K. E., Hasegawa, M., Isobe, Y., Kotsar, Y., Miyabe, H., Ozaki, H., Shiozawa, T., Sugimoto, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Bronner, C., Feng, J., Hayashino, T., Hiraki, T., Hirota, S., Huang, K., Jiang, M., Kikawa, T., Mori, M., Murakami, A., Nakamura, Ke., Nakaya, T., Patel, N. D., Suzuki, K., Takahashi, S., Tateishi, K., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Pritchard, A., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Mitsuka, G., Murase, M., Muto, F., Niwa, T., Suzuki, T., Tsukada, M., Frankiewicz, K., Mijakowski, P., Hignight, J., Jiang, J., Jung, C. K., Li, X., Palomino, J. L., Santucci, G., Vilela, C., Wilking, M. J., Yanagisawa, C., Fukuda, D., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kayano, T., Kibayashi, A., Kitagawa, H., Koshio, Y., Ma, W., Mori, T., Nagata, H., Piplani, N., Sakai, S., Sakuda, M., Takahira, Y., Xu, C., Yamaguchi, R., Kuno, Y., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Simpson, C., Wark, D., Nova, F., Tacik, R., Yang, J. Y., Cole, A., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Choi, Y., Kim, S. B., Yu, I., Ichikawa, A. K., Ito, K., Nishijima, K., Calland, R. G., de Perio, P., Martens, K., Murdoch, M., Vagins, M. R., Koshiba, M., Totsuka, Y., Iwamoto, K., Nakajima, Y., Ogawa, N., Suda, Y., Yokoyama, M., Hamabe, D., Izumiyama, S., Kuze, M., Okajima, Y., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Matsumoto, R., Ohta, K., Shinoki, M., Martin, J. F., Nantais, C. M., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., Prouse, N. W., Chen, S., Xu, B. D., Zhang, Y., Berkman, S., Tobayama, S., Connolly, K., Wilkes, R. J., Posiadala-Zezula, M., Hadley, D., Richards, B., Jamieson, B., Walker, J., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., and Sasaki, R.

Subjects
Physics - Instrumentation and Detectors, Large detector systems for particle and astroparticle physics, hep-ex, Cherenkov detectors, FOS: Physical sciences, Acceleratorfysik och instrumentering, Instrumentation and Detectors (physics.ins-det), Accelerator Physics and Instrumentation, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Particle identification methods, Neutrino detectors, Subatomic Physics, Cherenkov detectors Large detector systems for particle and astroparticle physics Neutrino detectors Particle identification methods, Detectors and Experimental Techniques, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), physics.ins-det, Mathematical Physics, Particle Physics - Experiment, astro-ph.IM
Abstract

We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218±9 μs. We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218 \pm 9 \mu s.

Published
2022

41. CD4 and IL-2 mediated NK cell responses after COVID-19 infection and mRNA vaccination in adults

Author

Amir M, Alhajjat, Catherine R, Redden, Morgan, Langereis, Steven T, Papastefan, Joy A S, Ito, Katherine C, Ott, Lucas E, Turner, HeeKap K, Kang, and Aimen F, Shaaban

Subjects
Immunology, Immunology and Allergy, Hematology
Abstract

A detailed understanding of protective immunity against SARS-CoV-2 is incredibly important in fighting the pandemic. Central to protective immunity is the ability of the immune system to recall previous exposures. Although antibody and T cell immunity have gained considerable attention, the contribution of the NK cell compartment to immune recall and protection from SARS-CoV-2 has not been explored. In this study, we investigate the NK cell responses to stimulation with SARS-CoV-2 in previously exposed and non-exposed individuals. We show that NK cells demonstrate an enhanced CD4+ T cell dependent response when re-exposed to SARS-CoV-2 antigen. The enhanced response is dependent on T cells and correlates with the number of SARS-CoV-2 specific CD4 T cells. We find that IL-2 is a critical mediator of NK cell function. These findings suggest that NK cells contribute to the protective responses against SARS-CoV-2 through a cooperation with antigen-specific CD4 T cells and have significant implications on our understanding of protective immunity in SARS-CoV-2.

Published
2023

42. Development and verification of a long-distance survey ahead of the tunnel face using excavation blasting as seismic source

Author

M Yamagami, T Ichiki, S Ito, and K Murata

Subjects
General Medicine, General Chemistry
Abstract

In mountain tunnelling, it is important from the point of construction safety and effectiveness to obtain information about the ground ahead of excavation, such as the positions of fracture zones and possible water inflows which may pose problems during construction. Seismic reflection surveys are used to survey the ground ahead of the face. While the maximum surveyable distance of conventional methods is 100-150 m, the authors are working on extending this ability to provide a long-distance outlook for tunnelling work and have developed a method known as Blast Excavation Prospecting (T-BEP). As a result of comparing conventional method in a verification experiment, it is found that T-BEP can detect a fracture zone with a width of 35 m about 350 m ahead of the face with an error of about 40 m..

Published
2023

43. Search for three body Pion Decays π+ → l+νX in the PIENU Experiment

Author

Shintaro Ito, A. Aguilar-Arevalo, M. Aoki, M. Blecher, D.I. Britton, D. Protopopescu, S. Ito, D.A. Bryman, D.vom Bruch, S. Cuen-Rochin, C. Malbrunot, T. Sullivan, S. Chen, J. Comfort, L. Doria, P. Gumplinger, L. Kurchaninov, R.E. Mischke, T. Numao, A. Sher, D. Vavilov, A. Hussein, Y. Igarashi, S. Kettell, and L. Littenberg

Subjects
Sterile Neutrinos and New Physics
Abstract

Parallel Contributed Talk at the "XIX International Workshop on Neutrino Telescopes" on line - 18-26 February, 2021

Published
2021
Full Text
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46. OP0112 THE EVER-LARGEST ASIAN GWAS FOR SYSTEMIC SCLEROSIS AND TRANS-POPULATION META-ANALYSIS IDENTIFIED SEVEN NOVEL LOCI AND A CANDIDATE CAUSAL SNP IN A CIS-REGULATORY ELEMENT OF THE FCGR REGION

Author

Y. Ishikawa, N. Tanaka, Y. Asano, M. Kodera, Y. Shirai, M. Akahoshi, M. Hasegawa, T. Matsushita, S. Kazuyoshi, S. Motegi, H. Yoshifuji, A. Yoshizaki, T. Kohmoto, K. Takagi, A. Oka, M. Kanda, Y. Tanaka, Y. Ito, K. Nakano, H. Kasamatsu, A. Utsunomiya, A. Sekiguchi, H. Niro, M. Jinnin, K. Makino, T. Makino, H. Ihn, M. Yamamoto, C. Suzuki, H. Takahashi, E. Nishida, A. Morita, T. Yamamoto, M. Fujimoto, Y. Kondo, D. Goto, T. Sumida, N. Ayuzawa, H. Yanagida, T. Horita, T. Atsumi, H. Endo, Y. Shima, A. Kumanogoh, J. Hirata, N. Otomo, H. Suetsugu, Y. Koike, K. Tomizuka, S. Yoshino, X. Liu, S. Ito, K. Hikino, A. Suzuki, Y. Momozawa, S. Ikegawa, O. Ishikawa, K. Takehara, T. Torii, S. Sato, Y. Okada, T. Mimori, F. Matsuda, K. Matsuda, I. Imoto, K. Matsuo, M. Kuwana, Y. Kawaguchi, K. Ohmura, and C. Terao

Subjects
Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract

BackgroundGenome-wide association studies (GWASs) have identified 29 disease-associated single nucleotide polymorphisms (SNPs) for systemic sclerosis (SSc) in non-human leukocyte antigen (HLA) regions (1-7). While these GWASs have clarified genetic architectures of SSc, study subjects were mainly Caucasians limiting application of the findings to Asians.ObjectivesThe study was conducted to identify novel causal variants for SSc specific to Japanese subjects as well as those shared with European population. We also aimed to clarify mechanistic effects of the variants on pathogenesis of SSc.MethodsA total of 114,108 subjects comprising 1,499 cases and 112,609 controls were enrolled in the two-staged study leading to the ever-largest Asian GWAS for SSc. After applying a strict quality control both for genotype and samples, imputation was conducted using the reference panel of the phase 3v5 1,000 genome project data combined with a high-depth whole-genome sequence data of 3,256 Japanese subjects. We conducted logistic regression analyses and also combined the Japanese GWAS results with those of Europeans (6) by an inverse-variance fixed-effect model. Polygenicity and enrichment of functional annotations were evaluated by linkage disequilibrium score regression (LDSC), Haploreg and IMPACT programs. We also constructed polygenic risk score (PRS) to predict SSc development.ResultsWe identified three (FCRLA-FCGR, TNFAIP3, PLD4) and four (EOMES, ESR1, SLC12A5, TPI1P2) novel loci in Japanese GWAS and a trans-population meta-analysis, respectively. One of Japanese novel risk SNPs, rs6697139, located within FCGR gene clusters had a strong effect size (OR 2.05, P=4.9×10-11). We also found the complete LD variant, rs10917688, was positioned in cis-regulatory element and binding motif for an immunomodulatory transcription factor IRF8 in B cells, another genome-wide significant locus in our trans-ethnic meta-analysis and the previous European GWAS. Notably, the association of risk allele of rs10917688 was significant only in the presence of the risk allele of the IRF8. Intriguingly, rs10917688 was annotated as one enhancer-related histone marks, H3K4me1, in B cells, implying that FCGR gene(s) in B cells may play an important role in the pathogenesis of SSc. Furhtermore, significant heritability enrichment of active histone marks and a transcription factor C-Myc were found in B cells both in European and Japanese populations by LDSC and IMPACT, highlighting a possibility of a shared disease mechanism where abnormal B-cell activation may be one of the key drivers for the disease development. Finally, PRS using effects sizes of European GWAS moderately fit in the development of Japanese SSc (AUC 0.593), paving a path to personalized medicine for SSc.ConclusionOur study identified seven novel susceptibility loci in SSc. Downstream analyses highlighted a novel disease mechanism of SSc where an interactive role of FCGR gene(s) and IRF8 may accelerate the disease development and B cells may play a key role on the pathogenesis of SSc.References[1]F. C. Arnett et al. Ann Rheum Dis, 2010.[2]T. R. Radstake et al. Nat Genet, 2010.[3]Y. Allanore et al. PLoS Genet, 2011.[4]O. Gorlova et al. PLoS Genet, 2011.[5]C. Terao et al. Ann Rheum Dis, 2017.[6]E. López-Isac et al. Nat Commun, 2019.[7]W. Pu et al. J Invest Dermatol, 2021.Disclosure of InterestsNone declared

Published
2022

47. POS0794 PREGNANCY AND CHILDBIRTH IN TAKAYASU ARTERITIS IN JAPAN – A NATIONWIDE RETROSPECTIVE STUDY

Author

T. Miyamae, Y. Manabe, T. Sugihara, N. Umezawa, H. Yoshifuji, N. Tamura, Y. Abe, S. Furuta, M. Kato, T. Kumagai, K. Nakamura, H. Nagafuchi, J. Ishizaki, N. Nakano, T. Atsumi, K. Karino, K. Amano, T. Kurasawa, S. Ito, R. Yoshimi, N. Ogawa, S. Banno, T. Naniwa, A. Hara, S. Hirahara, H. A. Uchida, Y. Onishi, Y. Murakawa, Y. Komagata, Y. Nakaoka, and M. Harigai

Subjects
Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract

BackgroundTakayasu arteritis (TAK), a granulomatous large vessel vasculitis, mainly involves the aorta and its proximal branches and commonly occurs in young females. However, studies of pregnancy in women with TAK are sparse and limited, probably due to the rarity of the disease.ObjectivesThe purpose of this study was to understand the status quo of medical treatments of the primary disease and outcomes of pregnancy in patients with TAK, and birth outcomes of the children in Japan.MethodsPatients with TAK who conceived after the onset of the disease and were managed at medical facilities participating in the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS) were retrospectively enrolled in this study. The following information was collected from patients who had a live-born baby: age at diagnosis of TAK, disease classification, age at delivery, treatments before and during pregnancy, complications during pregnancy, birth outcomes of the children, and changes in disease activity during pregnancy and after delivery.ResultsFifty-one cases and 69 pregnancies from 19 ethics committee-approved centers were enrolled during the study period 2019–2021. Of these, 49 cases and 66 pregnancies (95.7%) resulted in delivery and live-born babies. The Numano classification of the 49 cases was as follows: type I, 11; type IIa, 15; type IIb,12; type III, 1; type IV, 1; type V, 9; with type IIa being the most common. The age of diagnosis was 22 years (13–37 years, year of diagnosis 1965–2017), the median age of the delivery of 66 pregnancies was 31 years (year of delivery 1969-2021), and the median duration of illness at delivery was nine years. There were 34 planned pregnancies (51.5%, including four pregnancies by artificial insemination/ovulation induction). Preconception therapy included prednisolone (PSL) in 51 pregnancies (77.3%, median dose 7.5 mg (range 4–30 mg)/day), immunosuppressive drugs in 18 pregnancies (27.3%, azathioprine 8, tacrolimus 7, methotrexate 4, cyclosporin A 1, and colchicine 1), biologics in 12 pregnancies (18.1%, infliximab 6, tocilizumab 5, and adalimumab 1), antihypertensive drugs in 5 pregnancies (7.6%). Surgical treatment had been performed before pregnancy in 6 cases (aortic root replacement 2, subclavian artery dilatation 1, subclavian artery bypass 1, subclavian artery stenting 1, and ascending aorta semicircular artery replacement 1). Medications used during the course of pregnancy included PSL in 48 pregnancies (72.7%, median dose 8 mg (range 4–30 mg)/day, increased in 13 pregnancies, decreased in 1 pregnancy), immunosuppressants in 13 pregnancies (19.7%, azathioprine 6, tacrolimus 6, and cyclosporin A 1), biologics 9 pregnancies (13.6%, infliximab 4, tocilizumab 4, and adalimumab 1). Immunosuppressants and biologics were discontinued in five and four pregnancies after conception. Complications during pregnancy were observed in 20 pregnancies (30.3%), with hypertension being the most common. Complications related to TAK or its treatment were severe infections in two pregnancies and aneurysm enlargement due to increased circulating plasma volume in one pregnancy. Aortic arch replacement was performed after delivery for the latter case. Relapse of TAK was observed in 4 pregnancies (6.1%) during pregnancy and in 8 pregnancies (12.1%) after delivery. One pregnancy resulted in restenosis of subclavian artery for which dilatation procedure was performed prior to the pregnancy. There were 13/66 (19.7%) preterm infants and 17/59 (28.8%) low birth weight infants; all but one had a birth weight of more than 2,000 g and no had serious postnatal abnormalities. Forty-three (82.7%) of the 52 confirmed infants were breastfeed fully or mixed.ConclusionMost of the pregnancies in patients with TAK were successfully delivered while they had low disease activity at a dose of less than 10 mg/day of PSL. Relapse occurred during pregnancy and after delivery in some cases. The babies tended to have low birth weight, but 82.7% of them were breastfed without serious complications.Disclosure of InterestsTakako Miyamae: None declared, Yusuke Manabe: None declared, takahiko sugihara Speakers bureau: TS has received honoraria from Abbvie Japan Co., Ltd., AsahiKASEI Co., Ltd., Astellas Pharma Inc., Ayumi Pharmaceutical, Bristol Myers Squibb K.K., Chugai Pharmaceutical Co., Ltd., Eli Lilly Japan K.K., Mitsubishi-Tanabe Pharma Co., Ono Pharmaceutical, Pfizer Japan Inc., Takeda Pharmaceutical Co. Ltd., and UCB Japan Co., Grant/research support from: TS has received research grants from AsahiKASEI Co., Ltd., Daiichi Sankyo., Chugai Pharmaceutical Co., Ltd., and Ono Pharmaceutical., Natsuka Umezawa: None declared, Hajime Yoshifuji Speakers bureau: HY has received lecture fees from Janssen and Chugai., Naoto Tamura: None declared, Yoshiyuki Abe: None declared, Shunsuke Furuta Speakers bureau: Chugai Pharmaceutical Co.,Ltd.DaiichiSankyo Co.,Ltd.Asahi-Kasei Pharma Corporation, Manami Kato: None declared, Takashi Kumagai: None declared, Kaito Nakamura: None declared, Hiroko Nagafuchi: None declared, Jun Ishizaki: None declared, Naoko Nakano: None declared, Tatsuya Atsumi Speakers bureau: Mitsubishi Tanabe Pharma Co., Chugai Pharmaceutical Co., Ltd., Astellas Pharma Inc., Takeda Pharmaceutical Co., Ltd., Pfizer Inc., AbbVie Inc., Eisai Co. Ltd., Daiichi Sankyo Co., Ltd., Bristol-Myers Squibb Co., UCB Japan Co. Ltd., Eli Lilly Japan K.K., Novartis Pharma K.K., Eli Lilly Japan K.K., Kyowa Kirin Co., Ltd.,TAIHO PHARMACEUTICAL CO., LTD., Consultant of: AstraZeneca plc., MEDICAL & BIOLOGICAL LABORATORIES CO., LTD., Pfizer Inc., AbbVie Inc., ONO PHARMACEUTICAL CO. LTD.,Novartis Pharma K.K., Nippon Boehringer Ingelheim Co., Ltd., Grant/research support from: Astellas Pharma Inc., TAIHO PHARMACEUTICAL CO., LTD.AbbVie Inc., Nippon Boehringer Ingelheim Co., Ltd.,Takeda Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co. Ltd., Otsuka Pharmaceutical Co., Ltd. and Pfizer Inc. Alexion Inc., TEIJIN PHARMA LIMITED., Kohei Karino: None declared, Koichi Amano Speakers bureau: AbbVie GK, Asahi-Kasei Pharma, Astellas, Chugai Pharmaceutical Co.Ltd., Eisai, Eli Lilly, GlaxoSmithKlein, Janssen Pharma, Pfizer Japan, Grant/research support from: Asahi-Kasei Pharma,Chugai Pharmaceutical Co.Ltd., Takahiko Kurasawa: None declared, Shuichi Ito: None declared, Ryusuke Yoshimi: None declared, Noriyoshi Ogawa: None declared, Shogo Banno: None declared, Taio Naniwa Speakers bureau: Chugai, Tanabe, Abbbvie, Eisai, Grant/research support from: Chugai, Tanabe, Abbbvie, Eisai, Satoshi Ito Speakers bureau: SI has received speaker’s fees from pharmaceutical companies., Akinori Hara: None declared, Shinya Hirahara: None declared, Haruhito A. Uchida: None declared, Yasuhiro Onishi: None declared, Yohko Murakawa Speakers bureau: Astellas, UCB, Chugai, AbbVie, Grant/research support from: Chugai, AbbVie, Yoshinori Komagata: None declared, Yoshikazu Nakaoka: None declared, Masayoshi Harigai Speakers bureau: MH has received speaker’s fee from AbbVie Japan GK, Ayumi Pharmaceutical Co., Boehringer Ingelheim Japan, Inc., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Janssen Pharmaceutical K.K., Kissei Pharmaceutical Co., Ltd., Novartis Japan, Pfizer Japan Inc., Mitsubishi Tanabe Pharma Co., Teijin Pharma Ltd and UCB Japan., Consultant of: MH is a consultant for AbbVie, Boehringer-Ingelheim, Kissei Pharmaceutical Co., Ltd., and Teijin Pharma.

Published
2022

48. Prognostic value of sarcopenia and malnutrition in patients admitted for acute decompensated heart failure with reduced or preserved left ventricular ejection fraction

Author

Yoshio Furukawa, M Kawasaki, S Ito, Shunsuke Tamaki, K Ueda, K Kayama, M Seo, T Yamada, A Kikuchi, T Kawai, M Kawahira, Masatake Fukunami, Takashi Morita, J Nakamura, and T Watanabe

Subjects
medicine.medical_specialty, Ejection fraction, Acute decompensated heart failure, business.industry, medicine.disease, Malnutrition, Internal medicine, Sarcopenia, Cardiology, medicine, In patient, Cardiology and Cardiovascular Medicine, business, Value (mathematics)
Abstract

Background Sarcopenia and malnutrition are associated with poor clinical outcome in patients with chronic heart failure. However, there is little information available on the prognostic significance of the combination of sarcopenia and malnutrition in patients with acute decompensated heart failure (ADHF), relating to reduced or preserved left ventricular ejection fraction (HFrEF or HFpEF). Methods We prospectively studied 543 consecutive ADHF patients who survived to discharge (HFrEF [LVEF Results During a follow-up period of 2.8±1.4 years, 161 patients had all-cause death. Multivariate Cox analysis showed that both FFMI and GNRI were independently associated with all-cause death in both HFrEF (p=0.0064 and p Conclusions Sarcopenia or malnutrition at discharge was associated with all-cause death even in ADHF patients, irrespective of reduced or preserved LVEF. The combination of sarcopenia and malnutrition could provide prognostic information in ADHF patients with reduced LVEF. Funding Acknowledgement Type of funding sources: None. Figure 1

Published
2021

49. Low plasma levels of B-type natriuretic peptide predict the insulin resistance and left ventricular concentric remodeling in subjects without heart diseases: the observational arita cohort study

Author

Ken Matsuoka, M Amaki, S Ito, C Okamoto, Seiji Takashima, Masafumi Kitakaze, Osamu Tsukamoto, T Hasegawa, Tatsuro Hitsumoto, Hideaki Kanzaki, and Chisato Izumi

Subjects
medicine.medical_specialty, medicine.drug_class, business.industry, Plasma levels, Concentric, medicine.disease, Insulin resistance, Endocrinology, Internal medicine, Natriuretic peptide, medicine, Observational study, Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract

Introduction Although natriuretic peptides (NPs) are established as a biomarker of heart failure (HF), NPs have been attracting attention as a mediator in the metabolic sequences recently. On the other hand, metabolic disorders including insulin resistance have been suggested to be involved in left ventricular (LV) concentric remodeling, hinting us to the unexpected relationship among NPs, insulin resistance and LV concentric remodeling. Purpose To investigate whether the basal B-type natriuretic peptide (BNP) level is linked to insulin resistance or LV concentric remodeling in the participants independent of HF in the Japanese Arita-cho cohort study. Methods Among 1632 subjects who participated in annual health checks from 2005 to 2008 in Arita-cho, Saga, Japan as a cohort study, we studied 675 subjects without history of cardiovascular disease with LV ejection fraction≥50% and BNP level Results The tertile levels of BNP were inversely associated with HOMA-IR (the 1st tertile 1.33 (0.76–1.74), the 2nd tertile 1.05 (0.72–1.59), the 3rd tertile 0.95 (0.66–1.58), p=0.005); in the logistic regression analysis, the lower BNP level was related to the prevalence of insulin resistance defined as HOMA-IR≥1.37 after full multivariate adjustment (1 SD increment of BNP: adjusted odds ratio [aOR] 0.740, 95% confidence interval 0.601–0.912, P=0.005. LV concentric remodeling (RWT >0.42 and LV mass index ≤115 g/m2 in men and ≤95 g/m2 in women) was observed in 170 (25%) subjects; both low BNP level and higher insulin resistance were independently linked with LV concentric remodeling after multivariate adjustment (1 SD increment of BNP: aOR 0.714, 95% CI 0.544–0.938, p=0.015, HOMA-IR≥1.37 vs. Conclusions In the cohort without HF, the low BNP level was linked to insulin resistance and LV concentric remodeling independently, suggesting that the subjects with low NPs levels may cause metabolic disorders and LV morphological abnormalities. Funding Acknowledgement Type of funding sources: None.

Published
2021

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