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Solid-phase complexing of ibuprofen (IP) roll-mixed with beta-cyclodextrin (β-CD) has been investigated by measurement of powder X-ray diffraction patterns and complex yields in powder mixture systems. The roll-mixed system of IP and β-CD transformed readily to an amorphous form at the shear rate between rollers of 2.1 × 10 3 (s −1 ), to give an X-ray scattering pattern with three halo peaks around 13°, 18° and 24° (in 2θ). An inner halo peak site of complex formation appeared to shift slightly toward a lower diffraction angle. The yield of IP complex increased with increasing roll-mixing periods and shearing rates, and reached more than 90% for 10 min at 2.1 × 10 3 (s −1 ) shearing rate. The facts indicate that mechanochemical complexing of β-CD should occur in molecules such as IP capable of forming inclusion complexes.

Acoustic schwannoma is the most common tumor of the cerebellopontine angle in adults and is rarely found in children without neurofibromatosis. In the literature there are 18 children under the age of 16 with such tumor. Two female patients with age of 9 and 15 years old with acoustic schwannoma without neurofibromatosis are related. Progressive deafness followed by signs and symptoms of a posterior fossa tumor were the initial complaint of both, as well as of the other related cases and in adulthood.

This study evaluated the histologic responses of two different adhesive systems on the teeth of seven healthy adult monkeys. Class V cavities in 128 teeth were observed at 7,21 to 27, and 90 to 97 days. Statistical data showed no significant differences in pulp inflammation between the Optibond (Kerr), XR-Bond (Kerr), and IRM (Caulk) groups in pulps at the three time intervals. Some odontoblastic disruption and inflammation was seen in pulps restored with XR-Primer at the three time intervals. Pulp healing was similar in teeth treated with both direct-capped Optibond and calcium hydroxide, and there was no significant increase in pulpal inflammation with time. No abscesses or necrotic pulps were seen in any teeth. Optibond and XR-Bond adhesive systems are biologically acceptable in nonhuman primate pulp tissues.

This study evaluated the histologic response of total-etched and nonetched compomer restored cavity preparations. One hundred fifteen class 5 cavity preparations were placed in the teeth of four healthy adult monkeys at 7, 27, and 90 days. A 37% H3PO4 was applied for 10 seconds and rinsed in total-etched preparations. No statistical differences were seen in inflammatory reactions among total-etched or nonetched compomers at 7, 27, and 90 days. There were no statistical differences in inflammatory cell responses among all compomer systems in regard to time intervals. Pulpal responses of compomers were greater than IRM at each time period. Pulp responses were associated with stained bacteria in 32 of 89 compomer teeth. No necrotic pulps were seen in any teeth. Statistical data show a positive correlation (P0.05) between bacterial presence and pulpal inflammation. IRM pulps showed no inflammation or bacterial staining. Compomers are biologically compatible with pulp tissues when bacteria are excluded.

Class V cavities with mechanical exposures were prepared in 178 teeth of seven monkeys to observe the temporal healing of exposed pulps in direct contact with various dental materials, with or without a biologic seal of zinc-oxide eugenol cement against microleakage. Thirty pulps were direct capped as calcium hydroxide controls. The remaining 148 exposures were direct capped, 41 with silicate, 39 with zinc phosphate, 33 with amalgam, and 35 with an auto-cured composite. Sixty-four were restored to their cavosurface margin with their respective material and 84 were sealed to the covosurface margin with zinc-oxide eugenol cement. Tissues were obtained by perfusion fixation at intervals of 35, 21, 14, 10, 5, and 3 days, and then processed and evaluated. The results of this study demonstrated that exposed dental pulps possess an inherent healing capacity, allowing cell reorganization and dentin bridge formation when adequately sealed with zinc-oxide eugenol cement to prevent bacterial microleakage.

This article provides biological and technological information to support routine use of new cohesive bonding systems with definitive restorations. With these systems, clinicians may expect many advantages over the more traditional water soluble base and liner systems. Hybridization of vital dentin will prevent postoperative hypersensitivity under restorations and completely seal the tooth-restoration interface to prevent bacterial infection of the underlying substrate, ultimately reducing recurrent caries underneath the hybridized restoration.