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People spend a considerable portion of their lives indoors; thus, the quality of the indoor environment is crucial. Semi-volatile organic compounds (SVOCs) are among the primary indoor pollutants responsible for various health risks. This paper systematically reviews the impact of SVOC exposure on human health in Chinese built environments. Based on a set of criteria, we judged 12 publications as providing sufficient information on both SVOC exposure and health effects to inform the relationship. Out of six studies on polycyclic aromatic hydrocarbons (PAHs), three observed a positive association between PAH exposure and lung cancer. Out of six studies of phthalate exposure, two studies reported a significant positive association between DEP and DiBP and asthma, between DEP and DEHP and dry cough among children, and between DBP and rhinitis among younger adults. The results of this review suggest that there might be a link between phthalate exposure and asthma and allergies, as well as a link between PAH exposure and lung cancer. However, due to the limited number of studies conducted, more evidence is necessary to definitively guide the establishment of standards for SVOC control in China.

Background: Asthma, rhinitis, and eczema are becoming increasingly prevalent among children in China. Studies have shown that the perinatal period is critical and impacts children’s health. However, research on the associations between perinatal factors and childhood allergic diseases in China are few. Objective: To evaluate the associations between the home factors (dampness/ humidity, parental smoking, contact with animals, and renovation) and childhood allergic diseases around the perinatal periods in China. Method: This work is part of the China Child Health and Home (CCHH) study and is an analysis of data from a cross-sectional questionnaire investigation in urban Tianjin and rural Cangzhou, China, from 2013 to 2014. A total of 7,366 randomly selected kindergarten and elementary school children age 0-8 years old were investigated. The questions used in the study were modeled according to the Dampness in Buildings and Health (DBH) study conducted in Sweden. Results: The prevalence of children’s doctor-diagnosed asthma, rhinitis, and eczema were 4.1%, 9.5%, and 35.6%, respectively. There were associations between the indexes of dampness/humidity and allergic diseases, with an odd ratio of up to 4.02 at a 95% confidence interval: (1.87-8.64), after adjustment. The other perinatal factors (parental smoking, contact with animals, and renovation) also showed positive associations with the allergic conditions. Conclusion: The environmental factors around the perinatal period show strong associations with the allergic conditions discussed in this study. Further studies are needed to identify the biologic background and probable mechanisms for these associations.

Asthma, rhinitis, and eczema are becoming increasingly prevalent among children in China. Studies have shown that the perinatal period is critical and impacts children’s health. However, research on the associations between perinatal factors and childhood allergic diseases in China are few. We investigated 7366 children of ages 0–8 years old. The childhood asthma and allergies were surveyed by distributing questionnaires, modelled after Dampness in Buildings and Health (DBH) study in Sweden and had been validated. To determine the prevalence of the allergic conditions, explore for potential confounders, and analyze the associations between the allergies and the home environmental factors, chi-square test and binary logistic regression models (enter method) were employed. The prevalence of children’s doctor-diagnosed asthma, rhinitis, and eczema were 4.4%, 9.5%, and 39.1%, respectively. After adjusting for sociodemographic factors, the negative effect of dampness/humidity on children’s health became more obvious, with odd ratios (aORs) of up to 1.70 (95% confidence interval (CI): 1.12–2.57) for doctor-diagnosed asthma (DDA), 2.12 (95% CI: 1.38–3.25) for doctor-diagnosed rhinitis (DDR) and 1.79 (95% CI: 1.46–2.21) for doctor-diagnosed eczema (DDE). With parental smoking, aORs of up to 4.66 (95% CI: 1.99–10.92) for DDA and 1.74 (95%: 1.00–3.02) for DDE. Renovation exhibited aORs of up to 1.67 (95% CI: 1.13–2.47) for DDR. Although they showed no significant associations with some of the health outcomes, contact with animals, in general, were risk factors for the allergic conditions. Generally, the indoor environmental factors around the perinatal period were significant risk factors for the doctor-diagnosed allergic conditions discussed in this study.