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The article is devoted to the study of the problems of the training of physical therapists associated with the formation in students of a sufficient amount of knowledge and skills in etiology, diagnosis of deviations in the health of patients with disorders of the cardiovascular system, means and methods of physical therapy. The revealed topics are presented in the program of training students in the methods and technologies of working as a physical therapist with clients who have diseases of the cardiovascular system. As a result of studying the discipline, the student should know: basic concepts of general nosology; the role of factors, conditions and reactivity of the body in the occurrence, development and termination of diseases of the cardiovascular system; causes and mechanisms of diseases of the cardiovascular system, their manifestations and prognosis for the body during their development; etiology, pathogenesis, manifestations and consequences of the most frequent diseases of the cardiovascular system, principles of their etiological and pathogenetic therapy; – the value of the experimental method (modeling of diseases and painful states) in the study of diseases of the cardiovascular system; its possibilities, limitations and prospects. The student should be able to: – analyze clinical and laboratory, experimental and other data and formulate possible causes and mechanisms of development of diseases of the cardiovascular system based on them; apply the acquired knowledge when studying other clinical disciplines in further treatment and prevention activities; to analyze the problems of diseases of the cardiovascular system from the point of view of critical assessment of modern theoretical concepts and trends in medicine; to interpret the results of the most common methods of diagnosing diseases of the cardiovascular system; solve situational problems; skillfully conduct system surveys and collect history; to be able to conduct a physical examination, knowing the techniques of palpation, percussion and auscultation; by the nature of the temperature curve, determine the type of fever in inflammatory diseases of the cardiovascular system; interpret the results of basic diagnostic allergy tests; substantiate the principles of pathogenetic therapy of the most common diseases of the cardiovascular The content of the lecture material is revealed. The results of the survey of 38 students on 12 questions are presented. 100% of the surveyed students connected this discipline with the general field of study and felt the need to study it for their future work in the field. The material offered to students contributes to their preparation for work as a physical therapist with clients who have diseases of the cardiovascular system.

The leading method of physical therapy for children with Goldenhar syndrome is the specialization of socialization and communication skills. Goldehar's syndrome is genetically heterogeneous, develops spontaneously and is characterized by underdevelopment of the auricles, deformation and abnormal location, macrostomia, anomalies of the palate, interspinal tongue, and additional frenulums. Tasks of physical therapy: increasing the working capacity of the body, with the help of efforts with normal tolerance to fatigue, development of willpower (perseverance, determination, endurance, etc.); fixing the correct reactions to kinetic, visual, verbal stimuli. The performance of these exercises facilitates initially simple, and over time complex verbal instructions, they may not be supported by the demonstration of movements; to encourage the release of the activity of motor movements, so that they have a meaningful character, motor qualities, and the development of motor functions in the child. All this is aimed at the orderliness of the child's activity, which becomes purposeful, and the behavior is more disciplined; increasing the level of concentration: learning the ability to listen, consider, and perform clear, understandable actions; harmonization of the emotional component, formation of communication skills between adults and the child, precisely because of this, the restlessness and aggression that may arise in the child is removed; encouraging interest in communication, developing collectivism, learning to work in a team, promoting interpersonal interactions in a group. The construction of the process of learning communication and motor actions is determined by the laws of the formation of motor skills and takes place over a certain period. To form this, interaction with the world and physical development are required. Therefore, the formation of these skills is important for determining the directions of the child's integration in society. The use of an improved complex program of physical therapy made it possible to form some new communication stereotypes, which gave children the opportunity to perform new motor actions at a new level of motor functions, combining them with communication skills. This made it possible to increase the quality of children's socialization. The conducted studies show that the improvement of existing physical therapy programs can ensure the achievement of the maximum possible positive result and improvement of the general social and communication status of a child with the orphan disease Goldenhar syndrome.

Introduction. Antiphospholipid syndrome (APS) is one of the leading causes of nonarteritic anterior ischemic opticoneuropathy (AION) in young patients. Ocular pathology, often being the earliest and the only manifestation of APS, explains possible difficulties in diagnosis of this thrombophilic condition. Objective – to present a clinical case of bilateral anterior ischemic opticoneuropathy against the background of newly diagnosed antiphospholipid syndrome in a young patient. Materials and Methods. At admission, the patient, born in 1988, was diagnosed with bilateral acute ischemic nonarteritic ION on the basis of visual acuity decrease to 0,7, narrowing of peripheral borders of visual fields concentrically by 10–15°, optic disc edema (ODE) of both eyes and macular edema of the right eye according to ophthalmoscopy and optical coherence tomography (OCT). Laboratory examination revealed thrombocytopenia, antibodies to DNA and cardiolipin in elevated titer, which allowed the diagnosis of primary antiphospholipid syndrome. Local anticoagulant and anticoagulant therapy, systemic administration of antioxidants, antiaggregants, vitamins, as well as preparations, improving microcirculation, were carried out. Results and Discussion. Against the background of treatment visual function restored to 1.0 in the right eye and 0.9 in the left eye, residual ODE edema was diagnosed in both eyes in the upper nasal sector. At follow-up in 2.5 months the morphological parameters of the retina and optic nerve were restored. Conclusion. Thromboocclusive lesions of retinal and optic nerve vessels are an early and sometimes the only manifestation of antiphospholipid syndrome. Their presence in young patients requires clinical and laboratory follow-up examination for timely diagnosis of concomitant thrombophilic condition. High risk of recurrent thrombosis of different localization makes it necessary to take antiplatelet agents for a long time.

The article presents myofunctional therapy in young children with special needs. The literature is analyzed and it is shown that this problem is quite rare. It is shown that the influence of anomalies in the structure and functions of the dental system on the formation and development of the musculoskeletal system of the maxillofacial region and the speech-communication mechanism in children). The reasons for the appearance of myofunctional disorders in children are presented. The causes of myofunctional disorders are: dysfunction; bad habits; genetic predisposition. Indications for the correction of disorders of muscle tone of masticatory and facial muscles have been established. Groups of manifestations of myofunctional disorders in children of primary school age are characterized. The following groups of manifestations of myofunctional disorders have been identified: group I – myofunctional disorders caused by biological determinants; group II – myofunctional disorders caused by social determinants; group III – myofunctional disorders caused by biosocial determinants. Systems of work on correction of disorders in children are presented. A comparative quantitative and qualitative analysis of the positive dynamics in overcoming the manifestations of disorders of facial expressions, oral, articulatory praxis and physiological speech breathing is given. The system of work on the correction of myofunctional disorders in children of primary school age with special educational needs. It is proved that the complex application of kinesiotaping, orofacial and articulation massage, myogymnastics and long-term wearing of special trainers in the complex rehabilitation of myofunctional disorders in primary school children with special educational needs helped regulate the tone of facial expressions, chewing gum, and strength; reduction of hypersalivation; normalization of mobility of jaw joints, lower jaw, larynx; partial qualitative improvement of chewing and swallowing processes; reduce swelling and congestion in the muscles.

The prolongation of survival and the improvement of quality of life in patients with hemophilia A and B are only possible if hemostatic disorders caused by coagulation factor VIII and IX deficiency are managed effectively. Recombinant coagulation factors are playing an ever-increasing role in the preventive care of affected patients. The development, production and use of domestic recombinant coagulation factors opened up new treatment opportunities and improved access to preventive care for hemophilia patients. The results of clinical studies on the efficacy and safety of the Russian recombinant factors showed that they had similar efficacy and safety compared to the plasma derived clotting factors.

A thermodynamic model has been formulated for the formation work of a molecular aggregate consisting of molecules of a nonionic surfactant and a solubilisate in a hydrocarbon–surfactant–water solution as a function of temperature, concentrations of the surfactant and hydrocarbon in the solution, and aggregation numbers of the surfactant and hydrocarbon in the aggregate. The model depends on the structural parameters and physical characteristics of surfactant and solubilisate molecules. Predictions of the model concerning the minimum and the saddle point of the aggregation work have been considered and the distributions of relative concentrations of aggregates over the aggregation numbers of the surfactant and solubilisate have been plotted at different concentrations of surfactant and hydrocarbon monomers in the solution. The fractions of the surfactant and solubilisate in the aggregates have been numerically estimated relative to the equilibrium concentrations of surfactant and solubilisate monomers, and the average aggregation numbers of the surfactant and solubilisate in the aggregates have been found. The possibility of the colossal accumulation of solubilisate molecules in the molecular aggregates has been shown. The aggregation and solubilization have been considered at equilibrium surfactant concentrations that are markedly lower than the critical micelle concentration in a pure surfactant solution. It has been found that the limiting concentrations of the nonionic surfactant and the solubilisate corresponding to the formation of stable nanoemulsions lie in rather narrow ranges, and it is unlikely to get into them as a result of the random search in laboratory experiments.

All-atom molecular dynamics has been employed to study the processes of self-aggregation and solubilization in aqueous solutions that contain decane, ionic and nonionic surfactants, and additives of salts. In particular, micellization of an anionic surfactant (sodium dodecyl sulfate) in an aqueous solution has been simulated in the presence of a hydrocarbon (decane) at preset temperature and pressure and different initial surfactant and hydrocarbon concentrations in the solution. Moreover, self-aggregation has been simulated in systems containing water, decane, and a mixture of anionic (sodium dodecyl sulfate) and nonionic (hexaethylene glycol monodecyl ether, C10E6) both in a salt-free solution and in the presence of sodium chloride, calcium chloride, or a mixture thereof. Diffusion coefficients have been calculated for aggregates consisting of hydrocarbon and surfactant aggregates, and the viscosities of corresponding aqueous solutions have been estimated. The viscosities have been calculated in simulation cells containing either one or several aggregates.

Aim. To assess the prevalence of personality psychotype D, as well as its complex effect on levels of anxiety and depression, compliance and quality of life in outpatients with CVD. Materials and methods. The open prospective study included patients who were followed up on an outpatient basis at GAUZ TO “City Polyclinic No. 5” in Tyumen during 2016-2019. Everyone included in the study underwent generally accepted methods of clinical examination, as well as special methods of examination: determination of the N-Terminal fragment of the Brain Natriuretic Propeptide (NT-proBNP), assessment of points on the Hospital Anxiety and Depression Scale (HADS), the Morisky Green Test to determine adherence to treatment, conducting a personality psychotype test (DS-14), calculation of the number of points using a questionnaire to determine the quality of life (SF-36). Data analysis was carried out using statistical packages STATISTICA (version 22.0). For all analysis carried out, differences were considered significant at a two-tailed level of significance p < 0.05. Results. In total, the study included 141 patients (44 men and 97 women, mean age 68.9 ± 8.8 years). Personality type D was identified in 31.2% of patients. Individuals with personality psychotype D were characterized by a higher level of anxiety and depression, a lower quality of life on a number of scales by the quality of life questionnaire. Also, for the group with personality psychotype D, there was a multidirectional correlation between quality of life indicators, which was not found in the group without personality psychotype D. More than two thirds of patients with psychotype D were with insufficient adherence or non-adherence to treatment. Psychotype D is also characterized by a higher level of NTproBNP, which indicates a poorer state of the cardiovascular system in these patients, but no correlations were found between the state of the cardiovascular system and the quality of life in patients with personality psychotype D. Conclusion. The selection of patients with personality psychotype D in outpatient practice allows a more rational approach to CVD therapy, including methods of correcting chronic psychological factors, thereby improving the prognosis of patients.

The article is devoted to the study of the influence of the development of innovations on the economic security of the regions. Based on the assumption that innovative development plays a key role in the process of ensuring the economic security of the region, the authors proposed a system of indicators for assessing the innovative component of the economic security of the region, including the indicators of economic security reflected in the Decree «On the Strategy of Economic Security of the Russian Federation for the Period up to 2030». The impact of innovations is realized through the achievement of the goals of ensuring the country's security, among which is the dynamic and progressive development of the economy. The authors proposed a methodology for assessing the innovative component of economic security based on the scoring method, developed an assessment scale for interpreting the results of calculations, assessed the innovative security of regional economic systems of the Federal Districts of Russia for the period 2015–2019. As a result of the analysis, factors were identified that hinder innovative development and negatively affect the provision of economic security at the regional level: underdevelopment, low efficiency of the innovation infrastructure, reduction of internal costs for research and development, a decrease in the number of developed advanced production technologies, and others. It has been established that the economic security of a region depends on its ability to perceive innovations, while institutional factors have a significant impact on the pace of development. The work has improved the methodological tools for diagnosing the innovative security of the regions of the Russian Federation by optimizing the system of criteria for its assessment. The results of the empirical studies carried out confirmed the possibility of practical use of the developed methodology for diagnosing the innovative security of the regions of the Russian Federation and identifying priority areas for its improvement.

The expansion of viticulture in the world is accompanied by the spread of diseases and plant pests. Phylloxera is one of those organisms causing enormous damage to the world’s viticulture. The discovery of the possibility of grafting varieties on stock has led to the development of the breeding of stock originating from North America. Currently, the active use of different types of molecular markers for the identification and study of the genetic diversity of grapes allows to more accurately and efficiently study the biological peculiarities and genetics of plants. Obtaining good reproducibility of the analysis results and revealing the polymorphism between varieties and clones when using different types of markers, you can further use this knowledge for breeding in the selection of crossed pairs. The aim of the study in the present article was to study the common stock grape varieties - hybrids of American species. The article presents a study of the five most famous stock grape varieties: Kober 5BB and 420-A, Paulsen 1103, 101-14 and Richter 57 to identify genetic relationships and polymorphism between samples, based on the use of IRAP and iPBS primers. We used thirteen selected DNA markers that generated a total of 308 polymorphic DNA bands with 54.95 % polymorphism. The effectiveness of iPBS markers was comparable or even more effective than the markers based on retrotransposons. As a result of research, differences and commonality between stocks were clearly demonstrated by both cluster analysis and PCoA analysis.

Сьогодні Україна займає дев’яте місце у світі за кількістю внутрішньо переміщених осіб (ВПО). Масштабні вимушені внутрішні міграції останніх років не могли не відобразитися на стані здоров’я як певної соціальної групи, так і на стані здоров’я населення у цілому. Мета – вивчення факторів психічної травматизації, їх динаміки у часі та впливу на стан психічного здоров’я, визначення стресостійкості та соціальної адаптації у ВПО. Матеріал і методи. Методи обстеження включали клініко-психопатологічний з оцінкою факторів психічної травматизації, методику визначення стресостійкості та соціальної адаптації Т. Холмса і Р. Раге для оцінки актуального рівня стресу протягом останнього року, статистичні методи. Дослідження проведено в ДУ «Інститут неврології, психіатрії та наркології НАМН України» у відділі пограничної психіатрії. Всього було обстежено 213 ВПО. Усі обстежені були поділені на 3 групи: до І групи увійшли 94 ВПО із загальної популяції, у яких не було виявлено психічних розладів (умовно здорові); 68 осіб, у яких були визначені окремі психічні симптоми, що не сягали клінічного рівня, склали ІІ групу (група ризику) та 51 особа, що звернулася за медичною допомогою та мала діагностовані психічні розлади, увійшли до ІІІ групи (обстежені з психічними розладами). Результати. Всім обстеженим була проведена оцінка стресогенних факторів (СФ), що включали фізіологічні, психоемоційні, соціально-психологічні та інформаційні чинники та відображала їх динаміку в часі. Рівень опірності стресу відрізнявся у здорових, хворих та осіб з групи ризику. Висновки. Загальна оцінка впливу стресогенних чинників на ВПО свідчить про їх поєднану дію, різний ступінь патогенності та динаміки у часі.

This article is devoted to one of the main problems in marketing - development of marketing strategy for e-commerce in modern competitive conditions. The article deals with different methods of using marketing schemes, the main methods of information distribution and attracting new customers.

The problem of modeling the content of the chemical training of medical doctors is not new, but it is still urgent. Currently, having the properties of scale, fundamentality, interdisciplinarity, focus on the practice of learning, it is becoming one of the key problems of modern chemical education. The study of the problem of modeling the content of higher education is not so much in the plane of subject didactics as it has reached the state level. So, at the State Council Meeting [14] the task was set to “develop a set of measures aimed at systematically updating the content of education taking into account modern achievements of science and technology, changing students’ needs and society, focusing on the application of knowledge and skills in real life situations”. Our pedagogical experience shows that it is advisable to build promising models for the content of the chemical training of future doctors on the basis of the competence-based approach, guided by the principles of fundamentality, integrativeness, professional orientation, and rational minimization. Knowledge “sewn up” in context is necessary for students to understand the chemical nature of the processes occurring in the human body; close connection of chemistry with medicine, ecology; contribute to the formation of universal, professional, and in some cases professional competencies.

Milling of minerals and middlings is studied in ultra-fine bead mills, Vertimill fine milling machines and in hydropercussion-and-cavitation machines (rotary-pulsating type). Fine and ultra-fine milling provides the wanted rate of dissociation of sulphide minerals and host rocks as compared with ball milling, while hydropercussion-and-cavitation milling improves selectivity of dissociation at equal grain size composition of products from the rotary-pulsating machines and ball mills. Possible improvement of ore quality by fine hydraulic vibratory screening before deep concentration is examined. It is shown that as against hydrocyclones in pre-treatment circuits, fine hydraulic vibratory screens reduce circulation of fines with oversize flow, decrease overgrinding and increase mass fraction of optimal sizes for subsequent flotation.

The article presents the results of research carried out by the group of OOO "Archimedes" in 2018-2019. if possible, the use of an innovative method of herbicidal treatment of hard-to-reach areas affected by Sosnovsky's hogweed.

The article found that different precursors in crop rotation have an unequal effect on soil fertility, its weed infestation, infection with pathogens and plant pests.

The article found that the most important feature of proper agricultural technology is its complexity and differentiation depending on local soil-climatic, economic conditions and biological characteristics of cultivated crops.

The purpose of this study is to analyze the current state of the innovation susceptibility of the Russian regions and identify limitations for the realization of the benefits of digital transformation. The article considers the innovation susceptibility of the regional economy as a condition for its digitalization, suggests a methodology for assessing the innovation susceptibility of the regional economy, assesses the innovation susceptibility of individual areas of the Central Black Earth region and identifies problems of digital transformation. The purpose of the assessment is to identify the influence of various factors on the innovation susceptibility of the regional economy and the pace of its digital transformation.

Compliance with agronomic regulations in farms that ensure high quality seeds (conducting grade and species weeds on seed crops, compliance with harvesting, part-time, seed storage, etc.) must be constantly monitored in order to improve production on the way to the cultivation of high-quality seed material.

SUMMARY The research involved methods of remote sensing of the Earth, structural-morphometric analysis and geoinformation systems on the basis of which the connection and direct dependence of neotectonic movements, structural forms and modern relief were established. The main three morphostructural complexes (Kiev, Obukhiv, Kaniv-Trakhtemyriv blocks) were identified and analyzed, each with its own dominant factor. On the basis of the obtained indicators of the total amplitudes of the oscillations of the elevation of the relief, the features of the neotectonic evolution of different morphostructures, which are subject to individual rhythms, are revealed, and indicates the general complication of the morphostructural appearance of the region. It is confirmed that the northern regions of the region had an active upward movement dynamics in the Neogene epoch, and the southern ones in the Quaternary period. In general, the amplitude of fluctuations in the elevation of the elevation of the right bank of the Middle Dnieper in the Neogene-Quaternary period in the northern part was 100 m, in the southern - 135 m. Obtained data on the dynamics of the region can serve as a basis for the estimation of erosion-denudation and landslide processes within the Middle Dnieper.

The article examines the issues of risk assessment for reducing the financial stability of the enterprise. The content of the risk of financial stability is considered and the main approaches to its analysis are determined. The study revealed that the most common is the traditional approach. In the framework of this approach, key areas for analyzing the financial stability of an organization are defined and their meaningful characteristics are given. The results of the calculation and analysis of the risk of a decrease in financial stability depend on the presence/absence of distortions in the financial statements. Based on the conducted research, the organization's operations were identified, which can lead to a deterioration in the structure of the balance sheet and a decrease in financial stability. It is noted that the forecasting of financial difficulties will allow timely reacting to changes and developing adequate measures to reduce financial risks. The risk of reducing financial sustainability is multifaceted, and there is a high correlation between risk factors. In this regard, it seems appropriate to talk about the advisability of using a risk-oriented approach in the practice of financial stability management. This approach will solve the problem of ineffective management and non-compliance with legislation in the process of reflecting the facts of economic life, which will improve the quality of analysis of the financial situation of the enterprise. The proposed algorithm for managing the risk of reducing financial stability will make it possible to draw up a plan of action to minimize adverse impacts. In conclusion, it was concluded that sustainable development and stable status of economic entities in modern conditions is determined by their ability to respond in a timely manner to changing conditions of the functioning environment, which reflects the indicators of financial stability. Therefore, the necessary condition for the effective operation of the organization is its financial sustainability.

Periodic disease or Familial Mediterranean fever is an inherited monogenic disease widespread among the ancient peoples of the countries of Mediterranean region: Armenians, Jews, Turks, Arabs. MEFV gene (Familian Mediterranean Fever Gene) located on chromosome 16 in the region 16р13.3, is responsible for the development of the disease. MEFV gene encodes marenostrin protein (Pirin) involved in the regulation of inflammatory processes. Typical manifestations of the disease are recurrent fever, peritonitis, synovitis, pleuritis, and rarely pericarditis, meningitis, erysipeloid skin lesions, development of amyloidosis, mainly kidneys, is also characteristic. In the described clinical case the disease has manifested as recurrent interstitial lung disease and morphea-like skin lesion. Over 5 years the lung pathology was considered as cryptogenic organizing pneumonia, so the patient was administered corticosteroids (with no effect). In 2013, molecular genetic study detected mutations V726A and A744S in compaud-heterozygous state, the diagnosis of periodic disease was confirmed. Receiving colchicine for over 3.5 years induced remission of the disease: there were no episodes of febrile fever and exacerbations of pneumonia, radiologic regression of lung lesions and elimination of morphea-like skin lesion was observed. Clinical symptoms of periodic disease in this case are rarely encountered.