Search

In the current healthcare climate, reimbursement for services is increasingly linked to the ability to demonstrate beneficial patient outcomes. Neuropsychology faces some unique challenges in outcomes research, namely, that neuropsychologists often do not follow patients over time and the effect of neuropsychological services on patient outcomes may not be fully realized until under another provider’s care. Yet there is an urgent need for empirical evidence linking neuropsychological practice to positive patient outcomes. To provide a framework for this research, we define a core set of patient-centered outcomes and neuropsychological processes that apply across practice settings and patient populations. Within each area, we review the available existing literature on neuropsychological outcomes, identifying substantial gaps in the literature for future research. This work will be critical for the field to demonstrate the benefit of neuropsychological services, to continue to advocate effectively for reimbursement, and to ensure high-quality patient care.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

According to Numbers 26:57-59, Miriam and Aaron are the siblings of Moses. In the pericope studied here (Num 11:35-16:16) Moses is challenged by Miriam and Aaron both with regard to his marital choice and to his superior prophetic status. The present article attempts to explicate some of the philological and thematic difficulties in the text. In the light of the archaeological data currently available, which demonstrate that none of the narrative of the Torah is historical, the study suggests that Num 11:35-16:16 is addressed to a Jewish audience of the Achaemenid Persian period; a period in which a written Torah, an innovation, was in competition with oral prophecy, an older traditional form of divine revelation. By composing a tale in which YHWH himself affirmed the superiority of his communications to Moses over his communications to other prophets, the author of the pericope was, in fact, claiming that Scripture, which contained the divine word in its clearest form, was far more reliable than prophecy orally delivered.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

The two volumes under review derive their title from the author's char acterization of the biblical ber?t between Israel and its God (1:168-78). Through his voluminous publications, his teaching, and not the least his editing of ASOR publications and especially of the Anchor Bible Series, the Anchor Bible Dictionary, and the Anchor Bible Reference Library,1 Professor David Noel Freedman, now at the University of California at San Diego, is surely one of the most influential biblical scholars of the twenti eth century. The writings selected for these volumes, arranged chronologi cally, span about a half-century, providing the opportunity for an overview of the constant and the changing in Freedman's work.2 What is constant is Freedman's overriding preoccupation with the text, which he is always examining afresh. As he states in the preface (I:xvii; II:xvi): "Fifty years later I am still trying to make sense of biblical verses. The primary task of the student-scholar is to read the text closely and care

Ve-Eileh Divrei David: Essays in Semitics, Hebrew Bible and History of Biblical Scholarship, covers the career of S. David Sperling, a well-known and respected Biblical scholar.

Purpose: Interactions between chromatin-associated proteins and transcription factors play an important role in chromatin activation and gene regulation. They can be modulated by extracellular kinases, which are frequently activated by hormones and can phosphorylate chromatin-associated proteins to induce gene transcription. DPF3 is a member of the BAF (brahma-associated factor) chromatin remodeling complex and functions as an epigenetic factor to initiate gene transcription during heart and muscle development. Previous studies identified two isoforms of DPF3. DPF3b contains two PHD (plant homeo domain) fingers that recognize acetylated and methylated lysine residues of histone H3 and H4. However, very little is known of DPF3a, which contains a half-PHD finger. Here, we present the molecular mechanism of DPF3a regulation and its signaling cascade in myogenesis. Methods and Results: Using co-immunoprecipitation, we found that HEY proteins (HEY1, HEY2 and HEYL) are associated with BAF complex via the specific interaction with DPF3a. Further experiments showed that the posttranslational modification of DPF3a is essential for the interaction, which is mediated by the half-PHD finger of DPF3a. Using mass spectrometry, we identified three phosphorylation sites within DPF3a and in Tandem Affinity Purification we observed an interaction of DPF3a with all three subunits of the serine/threonine kinase CKII (casein kinase II). In vitro kinase assay showed that DPF3a is phosphorylated by CKII and inhibition of CKII by RNAi significantly reduces the DPF3a phosphorylation in vivo. DPF3a and HEY1 have common genomic targets; however, DPF3a is not capable of binding DNA directly. HEY1 knockdown in C2C12 skeletal muscle cells, combined with ChIP-qPCR demonstrated that the association of DPF3a with its targets is significantly reduced. Thus, HEY1 may represent the linker between DPF3a and its genomic targets. Interestingly, we found that the C-term of DPF3a shows high transcriptional activity in GAL4 transactivation assay and DPF3a significantly reduces HEY1 mediated repression of its targets (e.g. ANF, HEY1 and JAG1) using luciferase reporter assays. Conclusion: Our findings demonstrate an unprecedented mechanism of CKII-depending release of HEY1 from its genomic targets mediated by DPF3a and reveal a link between kinase activity and gene transcription mediated by a member of the BAF complex.