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217 results on '"Şekerel, Bülent"'

1. Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Author

Reshef, Avner, Buttgereit, Thomas, Betschel, Stephen D., Caballero, Teresa, Farkas, Henriette, Grumach, Anete S., Hide, Michihiro, Jindal, Ankur K., Longhurst, Hilary, Peter, Jonathan, Riedl, Marc A., Zhi, Yuxiang, Aberer, Werner, Abuzakouk, Mohamed, Al Farsi, Tariq, Al Sukaiti, Nashat, Al-Ahmad, Mona, Altrichter, Sabine, Aygören-Pürsün, Emel, Baeza, Maria Luisa, Bara, Noemi Anna, Bauer, Andrea, Bernstein, Jonathan A., Boccon-Gibod, Isabelle, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Bygum, Anette, Calderon, Oscar, de Albuquerque Campos, Regis, Campos Romero, Freya Helena, Cancian, Mauro, Chong-Neto, Herberto Jose, Christoff, George, Cimbollek, Stefan, Cohn, Danny M., Craig, Timothy, Danilycheva, Inna, Darlenski, Razvigor, Du-Thanh, Aurélie, Ensina, Luis Felipe, Fomina, Daria, Fonacier, Luz, Fukunaga, Atsushi, Gelincik, Asli, Giavina-Bianchi, Pedro, Godse, Kiran, Gompels, Mark, Goncalo, Margarida, Gotua, Maia, Guidos-Fogelbach, Guillermo, Guilarte, Mar, Kasperska-Zajac, Alicja, Katelaris, Constance H., Kinaciyan, Tamar, Kolkhir, Pavel, Kulthanan, Kanokvalai, Kurowski, Marcin, Latysheva, Elena, Lauerma, Antti, Launay, David, Lleonart, Ramon, Lumry, William, Malbran, Alejandro, Ali, Ramzy Mohammed, Nasr, Iman, Nieto-Martinez, Sandra, Parisi, Claudio, Pawankar, Ruby, Piñero-Saavedra, Macarena, Popov, Todor A., Porebski, Grzegorz, Prieto Garcia, Alicia, Pyatilova, Polina, Rudenko, Michael, Sekerel, Bulent Enis, Serpa, Faradiba Sarquis, Sheikh, Farrukh, Siebenhaar, Frank, Soria, Angèle, Staevska, Maria, Staubach, Petra, Stobiecki, Marcin, Thomsen, Simon Francis, Triggiani, Massimo, Valerieva, Anna, Valle, Solange, Van Dinh, Nguyen, Vera Ayala, Carolina Elisa, Zalewska-Janowska, Anna, Zanichelli, Andrea, Magerl, Markus, and Maurer, Marcus

Published
2024
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11. The treatment journey of children with moderate to severe atopic dermatitis in Türkiye: unmet needs.

Author

Gürel, Deniz İlgün, Ünsal, Hilal, Aytekin, Elif Soyak, Soyer, Özge, Şahiner, Ümit, Evans, Sibel Ersoy, and Şekerel, Bülent Enis

Abstract

Background. Atopic dermatitis (AD) substantially burdens individuals, families, and healthcare systems. We aimed to document the treatment journey of pediatric patients with moderate-to-severe AD in a referral center based in our country. Methods. This retrospective study reviewed patients aged 1-18 years diagnosed with AD, seeking systemic treatment recommendations from the "pediatric allergy and dermatology multidisciplinary team meeting". Results. Over the 14-month study period, 30 (12.5%) of 240 AD patients were evaluated in the pediatric dermato-allergy team meetings. The median age of the patients was 13.66 years (Q1-Q3: 7.94-17.27), of whom 60% were male. The median annual healthcare visits for AD were 4 (Q1-Q3: 1.00-8.75). Among the study group, 70% were sensitized to aeroallergens, and admission markers included total IgE (median: 1980 IU/mL, Q1-Q3: 794.50-5446), and eosinophil counts (median: 650, Q1-Q3: 275-1275). All patients utilized intermittent and/or continuous topical corticosteroids (CS), with 56.6% employing short-term/long-term topical tacrolimus. Over the past two years, systemic CSs were utilized in 93.3% of the patients, whereas 57.1% received more than one course. Approximately 43.3% of the patients agreed to receive systemic cyclosporine treatment, with only 30.8% benefiting and 3.3% reporting adverse effects (hypertrichosis and cellulitis). Three patients self-funded dupilumab, all benefiting without adverse effects. Omalizumab, mycophenolate mofetil and narrow-band ultraviolet (UV) treatments were used in one patient each, with limited benefit observed. Health insurance did not grant approval for a Janus kinase inhibitor for one patient. Conclusions. Managing moderate to severe AD is complex and costly, considering disease heterogeneity, comorbidities, care pathways, and health system challenges. Addressing the unmet needs should be a priority in Türkiye's healthcare systems. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination: Results of the UCARE COVAC-CU study

Author

Kocatürk, Emek, primary, Salameh, Pascale, additional, Sarac, Esra, additional, Vera Ayala, Carolina E., additional, Thomsen, Simon Francis, additional, Zuberbier, Torsten, additional, Ensina, Luis Felipe, additional, Popov, Todor A., additional, van Doorn, Martijn B.A., additional, Giménez-Arnau, Ana Maria, additional, Asero, Riccardo, additional, Criado, Paulo Ricardo, additional, Aarestrup, Fernando M., additional, AbdulHameed Ansari, Zainab, additional, Al Abri, Salma, additional, Al Ahmad, Mona, additional, Al Hinai, Bushra, additional, Allenova, Anastasiia, additional, Al-Nesf, Maryam, additional, Altrichter, Sabine, additional, Arnaout, Rand, additional, Bartosińska, Joanna, additional, Bauer, Andrea, additional, Bernstein, Jonathan A., additional, Bizjak, Mojca, additional, Bonnekoh, Hanna, additional, Bouillet, Laurence, additional, Brzoza, Zenon, additional, Calvalcanti Dela Bianca Melo, Ana Caroline, additional, Campinhos, Fernanda L., additional, Carne, Emily, additional, Purayil, Saleema Cherichi, additional, Cherrez-Ojeda, Ivan, additional, Chong-Neto, Herberto Jose, additional, Christoff, George, additional, Conlon, Niall, additional, Jardim Criado, Roberta Fachini, additional, Cvenkel, Klara, additional, Damadoglu, Ebru, additional, Danilycheva, Inna, additional, Day, Cascia, additional, de Montjoye, Laurence, additional, Demir, Semra, additional, Ferucci, Silvia Mariel, additional, Fomina, Daria, additional, Fukunaga, Atsushi, additional, Garcia, Elizabeth, additional, Gelincik, Asli, additional, Göbel, Joe Hannah, additional, Godse, Kiran, additional, Gonçalo, Margarida, additional, Gotua, Maia, additional, Grattan, Clive, additional, Gugala, Agata, additional, Guillet, Carole, additional, Kalyoncu, Ali Fuat, additional, Karakaya, Gul, additional, Kasperska-Zając, Alicja, additional, Katelaris, Constance H., additional, Khoshkhui, Maryam, additional, Kleinheinz, Andreas, additional, Kolacinska-Flont, Marta, additional, Kolkhir, Pavel, additional, Košnik, Mitja, additional, Krasowska, Dorota, additional, Kumaran, Muthu Sendhil, additional, Kuprys-Lipinska, Izabela, additional, Kurowski, Marcin, additional, Kuznetsova, Elizaveta V., additional, Larenas-Linnemann, Désirée, additional, Lebedkina, Marina S., additional, Lee, Youngsoo, additional, Makris, Michael P., additional, Gómez, René Maximiliano, additional, Nasr, Iman, additional, Neisinger, Sophia, additional, Oda, Yoshiko, additional, Kara, Rabia Öztaş, additional, Palitot, Esther Bastos, additional, Papapostolou, Niki, additional, Salvador Parisi, Claudio Alberto, additional, Pesque, David, additional, Peter, Jonathan, additional, Petkova, Elena, additional, Ridge, Katie, additional, Rudenko, Michael, additional, Rutkowski, Krzysztof, additional, Saini, Sarbjit S., additional, Salman, Andac, additional, Sanchez, Jorge, additional, Şekerel, Bülent, additional, Serdotetskova, Sofia A., additional, Serpa, Faradiba S., additional, Dikicier, Bahar Sevimli, additional, Sidiropoulos, Nikitas, additional, Sikora, Agnieszka, additional, Sørensen, Jennifer Astrup, additional, Soria, Angele, additional, Kucuk, Ozlem Su, additional, Thalappil, Sherin Rahim, additional, Tomaszewska, Katarzyna, additional, Tuncay, Gulseren, additional, Unal, Derya, additional, Valle, Solange, additional, van Lindonk, Esmee, additional, Vestergaard, Christian, additional, Vitchuk, Aleksandr, additional, Xepapadaki, Paraskevi, additional, Ye, Young-Min, additional, Zalewska-Janowska, Anna, additional, Zamlynski, Mateusz, additional, and Maurer, Marcus, additional

Published
2023
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15. Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination:Results of the UCARE COVAC-CU study

Author

Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael P., Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, Maurer, Marcus, Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael P., Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, and Maurer, Marcus

Abstract

Background: Concern about disease exacerbations and fear of reactions after coronavirus disease 2019 (COVID-19) vaccinations are common in chronic urticaria (CU) patients and may lead to vaccine hesitancy. Objective: We assessed the frequency and risk factors of CU exacerbation and adverse reactions in CU patients after COVID-19 vaccination. Methods: COVAC-CU is an international multicenter study of Urticaria Centers of Reference and Excellence (UCAREs) that retrospectively evaluated the effects of COVID-19 vaccination in CU patients aged ≥18 years and vaccinated with ≥1 dose of any COVID-19 vaccine. We evaluated CU exacerbations and severe allergic reactions as well as other adverse events associated with COVID-19 vaccinations and their association with various CU parameters. Results: Across 2769 COVID-19–vaccinated CU patients, most (90%) received at least 2 COVID-19 vaccine doses, and most patients received CU treatment and had well-controlled disease. The rate of COVID-19 vaccination–induced CU exacerbation was 9%. Of 223 patients with CU exacerbation after the first dose, 53.4% experienced recurrence of CU exacerbation after the second dose. CU exacerbation most often started <48 hours after vaccination (59.2%), lasted for a few weeks or less (70%), and was treated mainly with antihistamines (70.3%). Factors that increased the risk for COVID-19 vaccination–induced CU exacerbation included female sex, disease duration shorter than 24 months, having chronic spontaneous versus inducible urticaria, receipt of adenovirus viral vector vaccine, having nonsteroidal anti-inflammatory drug/aspirin intolerance, and having concerns about getting vaccinated; receiving omalizumab treatment and Latino/Hispanic ethnicity lowered the risk. First-dose vaccine–related adverse effects, most commonly local reactions, fever, fatigue, and muscle pain, were reported by 43.5% of CU patients. Seven patients reported severe allergic reactions. Conclusions: COVID-19 vaccination lead

Published
2023

18. A case‐control study of the effects of Aspergillus clinical phenotypes on pulmonary functions in patients with cystic fibrosis

Author

Nayir Buyuksahin, Halime, primary, Dogru, Deniz, additional, Emiralioglu, Nagehan, additional, Ademhan Tural, Dilber, additional, Özsezen, Beste, additional, Sunman, Birce, additional, Guzelkaş, Ismail, additional, Alboğa, Didem, additional, Arikan‐Akdagli, Sevtap, additional, Sarıbaş, Zeynep, additional, Gulmez, Dolunay, additional, Alp, Alpaslan, additional, Hazırolan, Gülşen, additional, Soyer, Özge, additional, Şekerel, Bülent Enis, additional, İnam, Gözde, additional, Irmak, İlim, additional, Damadoğlu, Ebru, additional, Kalyoncu, Fuat, additional, Yalçın, Ebru, additional, Ozcelik, Ugur, additional, and Kiper, Nural, additional

Published
2023
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19. In Chronic Spontaneous Urticaria, Complete Response to Antihistamine Treatment Is Linked to Low Disease Activity

Author

Türk, Murat, primary, Ertaş, Ragıp, additional, Şahiner, Ümit Murat, additional, Kolkhir, Pavel, additional, Şekerel, Bülent Enis, additional, Soyer, Özge, additional, Avcı, Atıl, additional, Atasoy, Mustafa, additional, Özyurt, Kemal, additional, Türk, Yekta, additional, Zeydan, Engin, additional, and Maurer, Marcus, additional

Published
2023
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28. Knowledge and satisfaction about the use of Patient Reported Outcomes Measures (PROMs) by patients with chronic urticaria

Author

Ojeda, Ivan Cherrez, Robles-Velasco, Karla, Kasperska-Zajac, Alicja, Kulthanan, Kanokvalai, Saengthong-aram, Phuwakorn, Sahiner, Umit Murat, Soyer, Ozge, Goncu, Emek Kocaturk, GÜREL, Deniz İLGÜN, Sekerel, Bulent, Özkaya, Esen, Latysheva, Elena, Meshkova, Raisa, Dias, Gabriela, Caraballo, Jorge Sanchez, Escalante, Luis, Maldonado, Astrid, Escalante, Edgar, Touriz, Maria, Calderon LLosa, Oscar, Podder, Indrashis, Nasr, Iman, Christoff, George, Intriago, Belen, Faytong-Haro, Marco, Rujitharanawong, Chuda, and Chularojanamontri, Leena

Published
2024
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36. Change in allergy practice during the COVID-19 pandemic

Author

Öztürk, Ayşe Bilge (ORCID 0000-0003-0166-424X & YÖK ID 147629), Baççıoğlu, Ayşe; Soyer, Özge; Civelek, Ersoy; Şekerel, Bülent Enis; Bavbek, Sevim, School of Medicine, Öztürk, Ayşe Bilge (ORCID 0000-0003-0166-424X & YÖK ID 147629), Baççıoğlu, Ayşe; Soyer, Özge; Civelek, Ersoy; Şekerel, Bülent Enis; Bavbek, Sevim, and School of Medicine

Abstract

Background: international guidelines in asthma and allergy has been updated for COVID-19 pandemic and pandemic has caused dramatic changes in allergy and immunology services. However, it is not known whether specialty-specific recommendations for COVID-19 are followed by allergists. Objectives: by conducting this study, we aimed to determine the attitudes and experiences of adult/pediatric allergists on allergy management during COVID-19. Method: We used a 20-question survey to elicit data from allergists (residents and pediatric and adult allergists registered to the Turkish National Society of Allergy and Clinical Immunology) across Turkey via e-mail. We analyzed the data statistically for frequency distributions and descriptive analysis. Results: a total of 183 allergists participated in the survey. Telemedicine was used for management of asthma (73%), allergic rhinitis (53%), atopic dermatitis (51%), chronic urticaria/angioedema (59%), drug hypersensitivity (45%), food allergy (48%), venom allergy (30%), anaphylaxis (22%), and hereditary angioedema (28%). Thirty-one percent of the respondents discontinued subcutaneous immunotherapy (SCIT) during the COVID-19 pandemic. Thirty-four percent of the physicians reported interruption of systemic steroid use in asthma patients, and 25% of the respondents discontinued biological therapy. Conclusions: allergists in Turkey have been using telemedicine at a high rate during the COVID-19 pandemic for asthma and rhinitis. The continuation rate of SCIT was low while the discontinuation rate of biologicals and systemic steroid use in asthma was high in Turkey.Our study results and learning from the experiences of other countries and specialties may help to optimize allergy practice and compatibility with international guidelines., NA

Published
2021

45. The relationship between oxidative stress markers in exhaled breath condensate and respiratory problems in patients with repaired esophageal atresia

Author

Soyer, Tutku, primary, Türer, Özlem Boybeyi, additional, Birben, Esra, additional, Kahveci, Melike, additional, Tuğcu, Gökçen Dilşa, additional, Soyer, Özge Uysal, additional, Yalçın, Ebru, additional, Doğru, Deniz, additional, Özçelik, Uğur, additional, Kiper, Nural, additional, Şekerel, Bülent, additional, and Tanyel, Feridun Cahit, additional

Published
2020
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48. Characteristics of food allergy in children: National multicenter study

Author

Bingöl, Ayşen, Uygun, Kocacık, Akdemir, Meltem, Erengin, Hakan, Bozdoğan, Günseli, Bingöl, Gülbin, Orhan, Fazıl, Büyüktiryaki, Betül, Şekerel, Bülent Enis, Kılıç, Mehmet, Saçkesen, Cansin, Eren Akarcan, Sanem, Demir, Esen, Köse, Şirin, Asilsoy, Suna, Kan, Ahmet, Türktaş, İpek, Arikoğlu, Tuğba, Kuyucu, Semanur, Sipahi, Seyhan, Tamay, Zeynep, Nacaroğlu, Tekin, Özdemir, Pınar Gökmirza, Yazıcıoğlu, Mehtap, Çekiç, Şükrü, Sapan, Nihat, Zeyrek, Dost, Doğruel, Dilek, Karakoç Aydıner, Elif, Özen, Ahmet Oğuzhan, Can, Ceren, Ertuğrul, Ayşin, Birol Bostancı, İlknur, Akçal, Ömer, Can, Demet, Arik Yılmaz, Ebru, Anıl, Hülya, Harmancı, Koray, Külhaş Çelik, İlknur, Civelek, Ersoy, Çokuğraş, Haluk, Şenol, Handan Duman, Tuncel, Tuba, Ufuk Altıntaş, Derya, and Acibadem University Dspace

Subjects
National Multicenter Study, Food Allergy, Children
Abstract

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019 Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study. European Academy of Allergy and Clinical Immunology

Published
2019

50. Rare occurrence of common filaggrin mutations in Turkish children with food allergy and atopic dermatitis

Author

Saçkesen, Cansın (ORCID 0000-0002-1115-9805 & YÖK ID 182537), Acar, Neşe Vardar; Cavkaytar, Özlem; Yılmaz, Ebru Arık; Büyüktiryaki, Betül; Soyer, Özge; Şahiner, Ümit Murat; Şekerel, Bülent Enis; Karaaslan, Çağatay, Saçkesen, Cansın (ORCID 0000-0002-1115-9805 & YÖK ID 182537), and Acar, Neşe Vardar; Cavkaytar, Özlem; Yılmaz, Ebru Arık; Büyüktiryaki, Betül; Soyer, Özge; Şahiner, Ümit Murat; Şekerel, Bülent Enis; Karaaslan, Çağatay

Abstract

Background/aim: filaggrin is a protein complex involved in epidermal differentiation and skin barrier formation. Mutations of the filaggrin gene (FLG) arc associated with allergen sensitization and allergic diseases like atopic dermatitis (AD), allergic rhinitis, food allergy (FA), and asthma. The aim of the study is to reveal the frequency of change in the FIG gene and determine the association between FIG loss-of-function (LOF) mutations and FA and/or AD in Turkish children. Materials and methods: four PLC loss-of-function (WO mutations known to be common in European populations were analyzed in 128 healthy children, 405 food-allergic children with or without atopic dermatitis, and 61 children with atopic dermatitis. PCRRFLP was performed for genotyping R501X, 2282del14, and R2447X mutations; 53247X was genotyped using a TaqMan-based allelic discrimination assay. Results were confirmed by DNA sequence analysis in 50 randomly chosen patients for all mutations. Results: a total of 466 patients [(67% male, 1 (0.7-2.8) years] and 128 healthy controls [59% male, 2.4 (1.4-3.5) years)] were included in this study. Two patients were heterozygous carriers of wild-type R501X, but none of the controls carried this mutation. Three patients and one healthy control were heterozygous carriers of wild-type 2282del4. Neither patients nor controls carried R2447X or S3247X PLC mutations. There were no combined mutations determined in heterozygous mutation carriers. Conclusions: although R501X, 2282del4, R2447X, and S3247X mutations are very common in European populations, we found that FIG mutations were infrequent and there is no significant association with food allergy and/or atopic dermatitis in Turkish individuals.

Published
2020

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