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237 results on '"Słojewski, Marcin"'

1. Prognostic Impact and Spatial Interplay of Immune Cells in Urothelial Cancer

Author

Debatin, Nicolaus F., Bady, Elena, Mandelkow, Tim, Huang, Zhihao, Lurati, Magalie C.J., Raedler, Jonas B., Müller, Jan H., Vettorazzi, Eik, Plage, Henning, Samtleben, Henrik, Klatte, Tobias, Hofbauer, Sebastian, Elezkurtaj, Sefer, Furlano, Kira, Weinberger, Sarah, Giacomo Bruch, Paul, Horst, David, Roßner, Florian, Schallenberg, Simon, Marx, Andreas H., Fisch, Margit, Rink, Michael, Slojewski, Marcin, Kaczmarek, Krystian, Ecke, Thorsten H., Hallmann, Steffen, Koch, Stefan, Adamini, Nico, Lennartz, Maximilian, Minner, Sarah, Simon, Ronald, Sauter, Guido, Zecha, Henrik, Schlomm, Thorsten, and Blessin, Niclas C.

Published
2024
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2. Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder

Author

Bruch, Paul Giacomo, Plage, Henning, Hofbauer, Sebastian, Kornienko, Kira, Weinberger, Sarah, Roßner, Florian, Schallenberg, Simon, Kluth, Martina, Lennartz, Maximilian, Blessin, Niclas C., Marx, Andreas H., Samtleben, Henrik, Fisch, Margit, Rink, Michael, Slojewski, Marcin, Kaczmarek, Krystian, Ecke, Thorsten, Hallmann, Steffen, Koch, Stefan, Adamini, Nico, Minner, Sarah, Simon, Ronald, Sauter, Guido, Zecha, Henrik, Klatte, Tobias, Schlomm, Thorsten, Horst, David, and Elezkurtaj, Sefer

Published
2023
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3. Cobalt Serum Level as a Biomarker of Cause-Specific Survival among Prostate Cancer Patients.

Author

Pietrzak, Sandra, Marciniak, Wojciech, Derkacz, Róża, Matuszczak, Milena, Kiljańczyk, Adam, Baszuk, Piotr, Bryśkiewicz, Marta, Sikorski, Andrzej, Gronwald, Jacek, Słojewski, Marcin, Cybulski, Cezary, Gołąb, Adam, Huzarski, Tomasz, Dębniak, Tadeusz, Lener, Marcin R., Jakubowska, Anna, Kluz, Tomasz, Soroka, Marianna, Scott, Rodney J., and Lubiński, Jan

Subjects
RESEARCH funding, PROSTATE tumors, CAUSES of death, COBALT, TUMOR markers, MULTIVARIATE analysis, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, STATISTICS, CANCER patient psychology, CONFIDENCE intervals, REGRESSION analysis
Abstract

Simple Summary: Prostate cancer is the most common cancer detected among men and it is the second leading cause of death. According to the WHO, cobalt is probably involved in carcinogenesis. However, there are no studies related to cobalt levels and survival in prostate cancer patients. The aim of this prospective study was to investigate the relationship between serum cobalt levels and survival among prostate cancer patients taking into consideration prostate cancer-specific deaths and non-cancer causes of death. Our findings, based on 261 Polish prostate cancer patients, show that individuals with high serum cobalt levels have a significantly worse survival compared to participants with low serum cobalt levels. Prostate cancer is the most common cancer diagnosed in men and the second leading cause of death in male cancer patients. The WHO suggests that cobalt is involved in the carcinogenesis of prostate cancer. There are, however, no studies associating cobalt levels and prostate cancer patient survival. In this study, 261 Polish prostate cancer (n = 261) patients were recruited into a prospective cohort between 2009 and 2015. Serum cobalt levels were measured using ICP-MS after prostate cancer diagnosis and before treatment. All study participants were assigned into quartiles (QI-QIV) based on the distribution of serum cobalt levels among censored patients. Univariable and multivariable COX regression models were used to calculate hazard ratios (HRs) for each serum cobalt level quartile. We found a significant relationship between high serum cobalt levels and poor prostate cancer patient total survival (HR = 2.60; 95% CI: 1.17–5.82; p = 0.02). In relation to prostate cancer patients who died as a result of other non-cancer causes, the association with high levels of cobalt was even stronger (HR = 3.67; 95% CI: 1.03–13.00; p = 0.04). The impact of high serum cobalt levels on overall survival of prostate cancer-specific-related deaths was not statistically significant. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Blood and Serum Se and Zn Levels and 10-Year Survival of Patients after a Diagnosis of Kidney Cancer.

Author

Złowocka-Perłowska, Elżbieta, Baszuk, Piotr, Marciniak, Wojciech, Derkacz, Róża, Tołoczko-Grabarek, Aleksandra, Słojewski, Marcin, Lemiński, Artur, Soczawa, Michał, Matuszczak, Milena, Kiljańczyk, Adam, Scott, Rodney J., and Lubiński, Jan

Subjects
RENAL cancer, OVERALL survival, CANCER-related mortality, SELENIUM, MORTALITY
Abstract

The aim of the project was to evaluate the association between selenium (Se) and zinc (Zn) levels in blood and serum and kidney cancer mortality. In a prospective group of 284 consecutive, unselected patients with kidney cancer, we evaluated their 10-year survival rate in relation to the levels of Se and Zn in their blood and serum. Micronutrient levels were measured using an inductively coupled plasma mass spectrometer. Patients were divided into quartiles based on the distribution of Se and Zn levels arranged in increasing order. The following variables were taken into account in the multivariable models: age at diagnosis, gender, smoking, type of surgery and histopathological examination results. We observed a statistically significant association of all-cause mortality when subgroups with low blood selenium levels were compared to patients with high selenium levels (HR = 7.74; p < 0.001). We found, in addition, that this correlation was much stronger when only men were assessed (HR = 11.6; p < 0.001). We did not find a statistically significant association for zinc alone. When we combined selenium and zinc levels (SeQI-ZnQI vs. SeQIV-ZnQIV), we observed the hazard ratio for kidney cancer death to be 12.4; p = 0.016. For patients in the highest quartile of blood zinc/selenium ratio, compared to those in the lowest, the HR was 2.53; p = 0.008. Our study suggests that selenium levels, combined selenium and zinc levels (SeQI-ZnQI vs. SeQIV-ZnQIV) and zinc-to-selenium ratio (Zn/Se) are attractive targets for clinical trials aimed at improving the survival of kidney cancer patients. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients

Author

Pietrzak, Sandra, primary, Marciniak, Wojciech, additional, Derkacz, Róża, additional, Matuszczak, Milena, additional, Kiljańczyk, Adam, additional, Baszuk, Piotr, additional, Bryśkiewicz, Marta, additional, Sikorski, Andrzej, additional, Gronwald, Jacek, additional, Słojewski, Marcin, additional, Cybulski, Cezary, additional, Gołąb, Adam, additional, Huzarski, Tomasz, additional, Dębniak, Tadeusz, additional, Lener, Marcin R., additional, Jakubowska, Anna, additional, Kluz, Tomasz, additional, Scott, Rodney J., additional, and Lubiński, Jan, additional

Published
2024
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6. Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial

Author

Park, Se Hoon, van der Heijden, Michiel S., Necchi, Andrea, Castellano, Daniel, Bamias, Aristotelis, Lee, Jae Lyun, De Giorgi, Ugo, Bögemann, Martin, Eigl, Bernhard J., Tsiatas, Marinos, Powles, Thomas, Novikov, Andrey, Skoneczna, Iwona, Mukherjee, Som D., Suarez, Cristina, Westgeest, Hans, Fradet, Yves, Flechon, Aude, Ou, Yen-Chuan, Park, Inkeun, Matveev, Vsevolod, Pérez-Valderrama, Begoña, Cheng, Susanna, Frank, Stephen, Gurney, Howard, Anido, Urbano, Hamzaj, Alketa, Retz, Margitta, Sridhar, Srikala, Scagliotti, Giorgio Vittorio, Voortman, Jens, Alekseev, Boris, Alyasova, Anna, Komyakov, Boris, Dumez, Herlinde, Pavic, Michel, Kimura, Go, Mizokami, Atsushi, Osanto, Susanne, Arranz, Jose Angel, Piersma, Djura, Shin, Sang Joon, Karyakin, Oleg, Delgado, Ignacio, Gonzalez, Jose Luis, Pang, See-Tong, Tran, Anna, Lipatov, Oleg, Su, Wen-Pin, Flaig, Thomas, Alva, Ajjai, Park Kyong, Hwa, Kopyltsov, Evgeny, Almagro, Elena, Domenech, Monserrat, Chang, Yen-Hwa, Sautois, Brieuc, Ravaux, Andre, Aravantinos, Gerasimos, Georgoulias, Vasileios, Mulder, Sasja, Kim, Yu Jung, Kater, Fabio, Chevreau, Christine, Tagawa, Scott, Zalewski, Pawel, Joly, Florence, Loriot, Yohann, Hatiboglu, Gencay, Gianni, Luca, Morelli, Franco, Tambaro, Rosa, Hashimoto, Yasuhiro, Nosov, Alexander, Font, Albert, Rodriguez-Vida, Alejo M., Jones, Robert, Vasudev, Naveen, Srinivas, Sandhya, Zhang, Jingsong, Gil, Thierry, Finch, Daygen, Grimm, Marc-Oliver, Su, Yu-Li, Chowdhury, Simon, Hocking, Christopher, Plas, Eugen, North, Scott, Jensen, Niels Viggo, Theodore, Christine, Imkamp, Florian, Peer, Avivit, Kobayashi, Takashi, Sakai, Hideki, Sassa, Naoto, Yoshimura, Kazuhiro, Aarts, Maureen, Ferreira Castro, Ana, Topuzov, Marlen, Rodriguez, Juan Francisco, Vazquez, Federico Jose, Tsai, Yu-Chieh, Crabb, Simon, Hussain, Syed, Bendell, Johanna, Gross-Goupil, Marine, Gwenaelle, Gravis, Berger, Raanan, Statsenko, Galina, Evans, Linda, Drakaki, Alexandra, Somer, Bradley, Davis, Ian, Lynam, James, Borges, Giuliano, Dettino, Aldo, Fay, André P., Martins, Graziella, Zucca, Luis Eduardo, Agerbaek, Mads, Kalofonos, Haralambos, Rosenbaum, Eli, Enokida, Hideki, Kikukawa, Hiroaki, Nishimura, Kazuo, Tamada, Satoshi, Uemura, Motohide, Lopez, Yamil, Gietema, Jourik, Slojewski, Marcin, Fernandes, Isabel, Smolin, Alexey, Mazhar, Danish, Kalebasty, Arash Rezazadeh, Carthon, Bradley, Loidl, Wolfgang, Franke, Fabio, Girotto, Gustavo, Alimohamed, Nimira, Macfarlane, Robyn, Pappot, Helle, Niegisch, Guenter, Mavroudis, Dimitrios, Sella, Avishay, Porta, Camillo, Ebara, Shin, Nakamura, Motonobu, Obara, Wataru, Okuno, Norihiko, Shinohara, Nobuo, Sugimoto, Mikio, Suzuki, Akitaka, Tokuda, Noriaki, Uemura, Hiroji, Yamaguchi, Akito, Ramirez, Francisco, Rozanowski, Pawel, Wiechno, Pawel, Keam, Bhumsuk, Kislov, Nikolay, Plaksin, Denis, Cicin, Irfan, Kumar, Satish, Galsky, Matthew D., Petrylak, Daniel P., Rosales, Joseph, Vaishampayan, Ulka, Culine, Stephane, Papandreou, Christos, Nara, Taketoshi, Erman, Mustafa, Kreiger, Laurence, Janoski, Juliana, Rosa, Diogo, Siqueira, Mariana, Canil, Christina, Sengelov, Lisa, Tourani, Jean-Marc, Arai, Gaku, Hashine, Katsuyoshi, Kawakita, Mutsushi, Nakaigawa, Noboru, Nomi, Hayahito, Shiina, Hiroaki, Suzuki, Hiroyoshi, Yonese, Junji, Kuri, Roberto, Macedo, Eleazar, Rivera, Samuel, Villalobos Prieto, Alberto, Polakiewicz-Gilowska, Anna, Zaucha, Renata, Lopes, Fabio, Ponomarev, Roman, Pomerantz, Mark, Shariat, Shahrokh, Luk, Cynthia, Lesniewski-Kmak, Krzysztof, van der Heijden, Michiel S, Galsky, Matthew D, Petrylak, Daniel P, Ogawa, Osamu, Lee, Jae-Lyun, Eigl, Bernhard J, Mukherjee, Som D, Suárez, Cristina, Fay, André P, Duran, Ignacio, Wildsmith, Sophie, He, Philip, Angra, Natasha, Gupta, Ashok K, Levin, Wendy, and Bellmunt, Joaquim

Published
2020
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11. Assessment of the incidence and risk factors of postoperative urosepsis in patients undergoing ureteroscopic lithotripsy.

Author

Kaczmarek, Krystian, Jankowska, Marta, Kalembkiewicz, Jakub, Kienitz, Jakub, Chukwu, Ositadima, Lemiński, Artur, and Słojewski, Marcin

Subjects
LITHOTRIPSY, URINARY tract infections, URINARY calculi, URETERIC obstruction, URETEROSCOPY
Abstract

Introduction Ureteroscopic lithotripsy (URSL) is an approved, minimally invasive, low-risk procedure for urolithiasis treatment. However, some patients may develop urinary tract infection (UTI) postprocedure, eventually leading to urosepsis. Determining the predictors of infection after URSL would help identify patients at a high risk of urosepsis, thereby enabling the early implementation of effective treatment. Therefore, we aimed to establish the incidence and predictors of urosepsis after URSL. Material and methods We assessed 231 patients who underwent URSL using a holmium laser. The incidence of urosepsis during the 30-day post-treatment period was analysed, and potential predictors of urosepsis, including patient characteristics and individual clinical factors, were examined. Results Statistical analysis revealed that 16.88% of patients had a confirmed positive urine culture before the procedure. Post-procedure urosepsis occurred in 4.76% of patients. Univariable analysis revealed that 3 factors were significantly associated with the risk of postoperative urosepsis: double-J stent insertion before URSL, pre-operative positive urine culture, and MDR pathogen found preoperatively. In multivariable analysis, only positive urine culture remained significantly associated with the risk of urosepsis after URSL. Conclusions Patients with positive urine culture before URSL are at significantly higher risk of urosepsis in the postoperative period. Hence, urine culture should be routinely performed before planned endoscopic urolithiasis treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Urethral stone of unexpected size: case report and short literature review

Author

Kaczmarek Krystian, Gołąb Adam, Soczawa Michał, and Słojewski Marcin

Subjects
calculi, diverticulum, urethra, urolithiasis, Medicine
Abstract

Urolithiasis is a well-known disease. Stones can form in all parts of the urinary tract. Diagnosis and treatment usually do not create clinical problems. However from time to time in daily practice doctors are confronted with casuistic cases. Here, we report a 54-year-old man with a large stone localized to the urethra. Because of the size of the stone, confirmed on radiography, and the presence of a cutaneous fistula, open surgery was performed. Due to urethral stricture, the patient required a second stage of reconstructive surgery. This case emphasizes that unusual presentation of urolithiasis may occur, and different surgical approaches as well as other surgical manipulations in such cases must be considered.

Published
2016
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20. The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men

Author

Polish Hereditary Prostate Cancer Consortium, Antczak, Andrzej, Wokołorczyk, Dominika, Kluźniak, Wojciech, Kashyap, Aniruddh, Jakubowska, Anna, Gronwald, Jacek, Huzarski, Tomasz, Byrski, Tomasz, Dębniak, Tadeusz, Masojć, Bartłomiej, Górski, Bohdan, Gromowski, Tomasz, Gołąb, Adam, Sikorski, Andrzej, Słojewski, Marcin, Gliniewicz, Bartłomiej, Borkowski, Tomasz, Borkowski, Andrzej, Przybyła, Jacek, Sosnowski, Marek, Małkiewicz, Bartosz, Zdrojowy, Romuald, Sikorska-Radek, Paulina, Matych, Józef, Wilkosz, Jacek, Różański, Waldemar, Kiś, Jacek, Bar, Krzysztof, Janiszewska, Hanna, Stawicka, Małgorzata, Milecki, Piotr, Lubiński, Jan, Narod, Steven A., and Cybulski, Cezary

Published
2015

22. Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience

Author

Nyk, Łukasz, primary, Kamecki, Hubert, additional, Krajewski, Wojciech, additional, Małkiewicz, Bartosz, additional, Szydełko, Tomasz, additional, Kubis, Markiian, additional, Słojewski, Marcin, additional, Kryst, Piotr, additional, Poletajew, Sławomir, additional, and Malewski, Wojciech, additional

Published
2022
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32. The presence of prostate cancer at biopsy is predicted by a number of genetic variants

Author

Kashyap, Aniruddh, Kluźniak, Wojciech, Wokołorczyk, Dominika, Gołąb, Adam, Sikorski, Andrzej, Słojewski, Marcin, Gliniewicz, Bartłomiej, Świtała, Jerzy, Borkowski, Tomasz, Borkowski, Andrzej, Antczak, Andrzej, Wojnar, Łukasz, Przybyła, Jacek, Sosnowski, Marek, Małkiewicz, Bartosz, Zdrojowy, Romuald, Sikorska-Radek, Paulina, Matych, Józef, Wilkosz, Jacek, Różański, Waldemar, Kiś, Jacek, Bar, Krzysztof, Bryniarski, Piotr, Paradysz, Andrzej, Jersak, Konrad, Niemirowicz, Jerzy, Słupski, Piotr, Jarzemski, Piotr, Skrzypczyk, Michał, Dobruch, Jakub, Domagała, Paweł, Piotrowski, Krzysztof, Jakubowska, Anna, Gronwald, Jacek, Huzarski, Tomasz, Byrski, Tomasz, Dębniak, Tadeusz, Górski, Bohdan, Masojć, Bartłomiej, van de Wetering, Thierry, Menkiszak, Janusz, Akbari, Mohammad R., Lubiński, Jan, Narod, Steven A., and Cybulski, Cezary

Published
2014
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36. Survival of Bladder or Renal Cancer in Patients With CHEK2 Mutations

Author

Złowocka-Perłowska, Elżbieta, primary, Dębniak, Tadeusz, additional, Słojewski, Marcin, additional, Lemiński, Artur, additional, Soczawa, Michał, additional, Wetering, Thierry van de, additional, Trubicka, Joanna, additional, Kluźniak, Wojcech, additional, Wokołorczyk, Dominika, additional, Cybulski, Cezary, additional, and Lubiński, Jan, additional

Published
2020
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37. Prediction of the risk of surgical complications in patients undergoing monopolar transurethral resection of bladder tumour – a prospective multicentre observational study

Author

Poletajew, Sławomir, primary, Krajewski, Wojciech, additional, Gajewska, Dominika, additional, Sondka-Migdalska, Joanna, additional, Borowik, Michał, additional, Buraczyński, Paweł, additional, Dzięgała, Mateusz, additional, Łykowski, Marcin, additional, Przudzik, Maciej, additional, Tukiendorf, Andrzej, additional, Woźniak, Rafał, additional, Bar, Krzysztof, additional, Jabłonowski, Zbigniew, additional, Roslan, Marek, additional, Słojewski, Marcin, additional, Zdrojowy, Romuald, additional, Radziszewski, Piotr, additional, and Dziobek, Konrad, additional

Published
2020
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40. Apoptosis and proliferation of the prostate cells in men with benign prostatic hyperplasia and concomitant metabolic disorders

Author

Rył, Aleksandra, Rotter, Iwona, Kram, Andrzej, Teresiński, Leszek, Słojewski, Marcin, Dołęgowska, Barbara, Lubkowska, Anna, Piasecka, Małgorzata, and Laszczyńska, Maria

Subjects
Benign prostatic hyperplasia, Proliferation, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Apoptosis, Metabolic syndrome
Abstract

Introduction. Apoptosis and proliferation of prostate cells are associated with both physiological increase and hyperplasia of the prostate. The aim of this study was to determine the contribution of metabolic syndrome to the processes of apoptosis and proliferation in gland epithelial cells and prostatic stromal cells in men with BPH. Materials and methods. The study involved 151 men, aged 52-89 years, receiving pharmacological treatment for BPH. The men were divided into two groups: those with and those without metabolic syndrome. The serum levels of the parameters were determined. Reactions for the identification of apoptosis (TUNEL) and proliferation (PCNA) in cells were also performed. Results. The relationships between the number of TUNEL(+) and PCNA(+) cells and metabolic syndrome were not observed. It was found that the total number of TUNEL(+) cells in the prostate stroma correlated negatively with the levels of highdensity lipoprotein and insulin-like growth factor-1. The analysis of the correlations in BPH patients with and without metabolic syndrome demonstrated that the only parameter correlating with the number of PCNA(+) cells in the prostate stroma was insulin resistance. Conclusion. Metabolic syndrome in patients with BPH had no impact on the number of TUNEL(+) and PCNA(+) cells in the prostate gland. However, the disturbed levels of metabolic parameters, and deviations of anthropometric parameters from normal may influence the number of apoptotic and proliferating cells.

Published
2018

41. The Relationship between Eicosanoid Levels and Serum Levels of Metabolic and Hormonal Parameters Depending on the Presence of Metabolic Syndrome in Patients with Benign Prostatic Hyperplasia

Author

Grzesiak, Katarzyna, primary, Rył, Aleksandra, additional, Stachowska, Ewa, additional, Słojewski, Marcin, additional, Rotter, Iwona, additional, Ratajczak, Weronika, additional, Sipak, Olimpia, additional, Piasecka, Małgorzata, additional, Dołęgowska, Barbara, additional, and Laszczyńska, Maria, additional

Published
2019
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43. Correlation between malnutrition, body mass index and complications in patients with urinary bladder cancer who underwent radical cystectomy

Author

Swalarz, Marta, primary, Swalarz, Grzegorz, additional, Juszczak, Kajetan, additional, Maciukiewicz, Piotr, additional, Czurak, Krzysztof, additional, Matuszewski, Marcin, additional, Gajewska, Dominika, additional, Słojewski, Marcin, additional, Bogacki, Rafał, additional, Bryniarski, Piotr, additional, Paradysz, Andrzej, additional, Kadłubowski, Mateusz, additional, Drewa, Tomasz, additional, and Genge, Ewa, additional

Published
2018
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44. Comparison between selected hormone and protein levels in serum and prostate tissue homogenates in men with benign prostatic hyperplasia and metabolic disorders

Author

Grzesiak, Katarzyna, primary, Rył, Aleksandra, additional, Baranowska-Bosiacka, Irena, additional, Rotter, Iwona, additional, Dołęgowska, Barbara, additional, Słojewski, Marcin, additional, Sipak-Szmigiel, Olimpia, additional, Ratajczak, Weronika, additional, Lubkowska, Anna, additional, Metryka, Emilia, additional, Piasecka, Małgorzata, additional, and Laszczyńska, Maria, additional

Published
2018
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47. Molecular Analysis of the SRD5A1 and SRD5A2 Genes in Patients with Benign Prostatic Hyperplasia with Regard to Metabolic Parameters and Selected Hormone Levels

Author

Rył, Aleksandra, primary, Rotter, Iwona, additional, Grzywacz, Anna, additional, Małecka, Iwona, additional, Skonieczna-Żydecka, Karolina, additional, Grzesiak, Katarzyna, additional, Słojewski, Marcin, additional, Szylińska, Aleksandra, additional, Sipak-Szmigiel, Olimpia, additional, Piasecka, Małgorzata, additional, Walczakiewicz, Kinga, additional, and Laszczyńska, Maria, additional

Published
2017
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