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Ya z›fl ma Ad re si/Ad dress for Cor res pon den ce Dr. Zelal Kahramaner, Adiyaman Universitesi Tip Fakultesi, Kadin Dogum ve Cocuk Hastanesi, Yenidogan Klinigi, Adiyaman, Turkiye Gsm: +90 506 947 74 58 E-posta: zelaldr@hotmail.com Ge lis ta ri hi/Re cei ved: 06.10.2013 Ka bul ta ri hi/ Ac cep ted: 04.11.2013 1Adiyaman Universitesi Tip Fakultesi, Kadin Dogum ve Cocuk Hastanesi, Yenidogan Klinigi, Adiyaman, Turkiye 2Adiyaman Universitesi Tip Fakultesi, Kadin Dogum ve Cocuk Hastanesi, Radyoloji Klinigi, Adiyaman, Turkiye 3Adiyaman Universitesi Tip Fakultesi, Tibbi Genetik Anabilim Dali, Adiyaman, Turkiye Aydin Erdemir1, Zelal Kahramaner1, Mehmet Tekin1, Sumeyye Ercan1, Bilal Arik2, Ozgur Cevik3

Ya z›fl ma Ad re si/Ad dress for Cor res pon den ce Dr. Zelal Kahramaner, Adiyaman Universitesi Tip Fakultesi, Kadin Dogum ve Cocuk Hastanesi, Yenidogan Klinigi, Adiyaman, Turkiye Gsm: +90 506 947 74 58 E-posta: zelaldr@hotmail.com Ge lis ta ri hi/Re cei ved: 07.10.2013 Ka bul ta ri hi/ Ac cep ted: 27.10.2013 1Adiyaman Universitesi Tip Fakultesi, Kadin Dogum ve Cocuk Hastanesi, Yenidogan Klinigi, Adiyaman, Turkiye 2Dokuz Eylul Universitesi Tip Fakultesi, Tibbi Genetik Anabilim Dali, Izmir, Turkiye 3Adiyaman Universitesi Tip Fakultesi, Kadin Dogum ve Cocuk Hastanesi, Radyoloji Klinigi, Adiyaman Zelal Kahramaner1, Aydin Erdemir1, Ozlem Giray Bozkaya2, Mehmet Tekin1, Sumeyye Ercan1, Bilal Arik3

Aim: To investigate the association between serum 25-hydroxyvitamin D (25(OH)D3) levels and transient tachypnea of the newborn (TTN). Methods: Calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathormone (PTH) and serum 25(OH)D3 levels were measured in 51 infants diagnosed with TTN and 59 healthy control infants for comparison. Demographic factors including gestational age, birth weight, gender, delivery mode, parity, vitamin D supplementation during pregnancy and severity of TTN were recorded. Results: The serum levels of 25(OH)D3 were significantly lower in infants with TTN compared to infants with no respiratory distress (p < 0.01). There was no statistically significant difference in serum Ca, P and ALP levels between the groups while the serum levels of PTH were significantly higher in the study group (p < 0.01). No correlation was found between the serum 25(OH)D3 levels and severity of TTN. Vitamin D supplementation (400 IU/day) during pregnancy did not affect the serum levels of newborns. Conclusion: Our data suggests that lower 25(OH)D3 serum levels are associated with an increased risk of TTN and vitamin D may have a role in the pathogenesis of TTN.

The type of congenital heart disease, early diagnosis, and treatment modality all play an important role in the morbidity and mortality of these diseases. This study examined the relationship between congenital heart disease and oxidative stress in children with cyanotic and acyanotic congenital heart disease.In this case-controlled cross-sectional study, the study groups consisted of 29 patients with cyanotic heart disease, 30 patients with acyanotic heart disease, and a control group of 32 healthy individuals. For all groups, the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were calculated. Of the cyanotic group, 12 were diagnosed with tetralogy of Fallot, 7 with transposition of the great arteries, 4 with tricuspid atresia, 4 with double outlet right ventricle and 2 with truncus arteriosus. In the acyanotic group 19 patients had ventricular septal defect (VSD), 5 atrial septal defect (ASD) and 6 patent ductus arteriosus (PDA). Statistical analyses were performed using Chi-square, Mann-Whitney U and Kruskal-Wallis tests.The plasma TAS, TOS, and OSI were significantly higher in the cyanotic group than in the acyanotic group (p0.0001, p0.01, and p0.01, respectively) and controls (p0.0001, p0.0001, and p0.0001, respectively). A comparison between the acyanotic and control groups showed no statistical differences.The level of oxidative stress in patients with cyanotic congenital heart disease was significantly higher than in the acyanotic and control groups, which were similar.