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6. Comparative analysis of machine learning algorithms for multi-syndrome classification of neurodegenerative syndromes

Author

Lampe, Leonie, Niehaus, Sebastian, Huppertz, Hans-Jürgen, Merola, Alberto, Reinelt, Janis, Mueller, Karsten, Anderl-Straub, Sarah, Fassbender, Klaus, Fliessbach, Klaus, Jahn, Holger, Kornhuber, Johannes, Lauer, Martin, Prudlo, Johannes, Schneider, Anja, Synofzik, Matthis, Danek, Adrian, Diehl-Schmid, Janine, Otto, Markus, Villringer, Arno, Egger, Karl, Hattingen, Elke, Hilker-Roggendorf, Rüdiger, Schnitzler, Alfons, Südmeyer, Martin, Oertel, Wolfgang, Kassubek, Jan, Höglinger, Günter, and Schroeter, Matthias L.

Published
2022
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11. Utilization of MANAGE-PD Tool in a Real-World Setting in Germany: A Cross-Sectional Study.

Author

Südmeyer, Martin, Pedrosa, David J., Siebecker, Frank, Arlt, Carolin, Kopra, Jaakko J., and Jost, Wolfgang H.

Subjects
*PARKINSON'S disease, *JUDGMENT (Psychology), *ORAL medication, *NEUROLOGISTS, *PHYSICIAN services utilization
Abstract

MANAGE-PD is a validated, web-based tool to assist physicians in identifying patients with Parkinson's disease (PD) whose symptoms are inadequately controlled by oral medication. Also, a modified patient version of MANAGE-PD (Parkinson Check) is available in Germany. However, prospective research into the clinical utility of MANAGE-PD is lacking. This non-interventional study aimed to assess the real-world clinical utility of the MANAGE-PD and Parkinson Check in PD patients attending a single visit at specialist clinics and neurologist practices in Germany in 2022. Participants' disease control was rated by the physicians using their own judgment, and by completing the MANAGE-PD, and by the patients completing the Parkinson Check. Concordance was calculated between the unassisted physician's assessment and the outcome of MANAGE-PD, as well as the Parkinson Check. A total of 278 patients from 19 sites were included in the analyses, of whom 160 patients (57.6%) were assigned to the same category of disease control by physicians' judgment and the MANAGE-PD. Concordance was higher in patients treated in specialist clinics (63.9%) than in neurologist practices (43.7%). Concordance between physicians' and patients' responses was high (>80%) for each question in the Parkinson Check. MANAGE-PD proved to be especially valuable for general neurologists in identifying patients who should be referred to specialist clinics. The Parkinson Check self-assessment generated promising outcomes that merit its more widespread use. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial

Author

André, Elisabeth, Blankenstein, Christiane, Canelo, Monica, Düring, Marco, Ebentheuer, Jens, Fricke, Christopher, Gerbes, Alexander, Groiss, Stefan, Gruber, Doreen, Hartmann, Christian, Kirchner, Thomas, Kroneberg, Daniel, Kunz, Martin, Lorenzl, Stefan, Moldovan, Alexia, Noda, Anna, Pape, Heidi, Respondek, Gesine, Schäffer, Eva, Schneider, Martina, Schnitzler, Alfons, Schulz-Schaeffer, Walter, Schwarz, Johannes, Skowronek, Cornelia, Storch, Alexander, Tadic, Vera, Vadász, Dávid, Zimmermann, Benno, Levin, Johannes, Maaß, Sylvia, Schuberth, Madeleine, Giese, Armin, Oertel, Wolfgang H, Poewe, Werner, Trenkwalder, Claudia, Wenning, Gregor K, Mansmann, Ulrich, Südmeyer, Martin, Eggert, Karla, Mollenhauer, Brit, Lipp, Axel, Löhle, Matthias, Classen, Joseph, Münchau, Alexander, Kassubek, Jan, Gandor, Florin, Berg, Daniela, Egert-Schwender, Silvia, Eberhardt, Cornelia, Paul, Friedemann, Bötzel, Kai, Ertl-Wagner, Birgit, Huppertz, Hans-Jürgen, Ricard, Ingrid, and Höglinger, Günter U

Published
2019
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15. Nationwide Retrospective Analysis of Combinations of Advanced Therapies in Patients With Parkinson Disease

Author

Pürner, Dominik, primary, Hormozi, Mohammad, additional, Weiß, Daniel, additional, Barbe, Michael T., additional, Jergas, Hannah, additional, Prell, Tino, additional, Gülke, Eileen, additional, Pötter-Nerger, Monika, additional, Falkenburger, Björn, additional, Klingelhöfer, Lisa, additional, Gutsmiedl, Pia K., additional, Haslinger, Bernhard, additional, Jochim, Angela M., additional, Wolff, Andreas, additional, Schröter, Nils, additional, Rijntjes, Michel, additional, van Riesen, Christoph, additional, Scheller, Ute, additional, Wolz, Martin, additional, Amouzandeh, Ali, additional, Ebersbach, Georg, additional, Gruber, Doreen, additional, Kohl, Zacharias, additional, Maetzler, Walter, additional, Paschen, Steffen, additional, Pérez-González, Pablo, additional, Rozanski, Verena, additional, Schwarz, Johannes, additional, Südmeyer, Martin, additional, Torka, Elisabeth, additional, Wesbuer, Simone, additional, Bornmann, Sarah, additional, Flöel, Agnes, additional, Ip, Chi Wang, additional, Krause, Patricia, additional, Kühn, Andrea A., additional, Csoti, Ilona, additional, Herting, Birgit, additional, van de Loo, Simone, additional, Basheer, Aniz Ahammed, additional, Liszka, Robert, additional, Jost, Wolfgang H., additional, Koschel, Jiri, additional, Haller, Bernhard, additional, and Lingor, Paul, additional

Published
2023
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19. Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial

Author

Negovanska, Velina, Welter, Marie-Laure, Corvol, Jean-Christophe, Agid, Yves, Navarro, Soledad, Meier, Niklaus, Hartmann, Andreas, Hesekamp, Helke, Cornu, Philippe, Möller, Bettina, Nebel, Adelheid, Raethjen, Jan, Knudsen, Karina, Volkmann, Jens, Falk, Daniela, Paschen, Steffen, Meister, Ingo, Kuhn, Jens, Donner, Kerstin, Kessler, Josef, Barbe, Michael, Fink, Gereon, Maarouf, Mohammad, Kühn, Andrea, Müller, Bianca, Faust, Katharina, Gruber, Doreen, Schneider, Gerd-H., Seigneuret, Eric, Pollak, Pierre, Fraix, Valerie, Kistner, Andrea, Rascol, Olivier, Arbus, Christophe, Danet, Lola, Chaynes, Patrick, Groiss, Stefan J., Hartmann, Christian, Südmeyer, Martin, Partowinia-Peters, Mahnaz, Vesper, Jan, Ledily, Severine, Damier, Philippe, Raoul, Sylvie, Trenkwalder, Claudia, Richter-Dreske, Wenke, Wächter, Tobias, Weiss, Daniel, Eusebio, Alexandro, Azulay, Jean Philippe, Polo, Gustavo, Pinto, Serge, Levin, Johannes, Dornier, Stephanie, Pene, Fredy, Hourton, Delphine, Quintin, Mathieu, Hoffart-Jourdain, Cecile, Brocvielle, Helene, Balthasar, Kerstin, Stein, Meryem, Harnisch, Susanne, Reuss, Alexander, Aminossadati, Behnaz, Nasemann, Christian, Oertel, Wolfgang, Bataille, Benoit, Hellwig, Dieter, Gharabaghi, Alireza, Amtage, Florian, Mertens, Patrick, Kloss, Manja, Post, Bart, Speelman, Hans, Lhommée, Eugénie, Wojtecki, Lars, Czernecki, Virginie, Witt, Karsten, Maier, Franziska, Tonder, Lisa, Timmermann, Lars, Hälbig, Thomas D, Pineau, Fanny, Durif, Franck, Witjas, Tatiana, Pinsker, Marcus, Mehdorn, Maximilian, Sixel-Döring, Friederike, Kupsch, Andreas, Krüger, Rejko, Elben, Saskia, Chabardès, Stephan, Thobois, Stéphane, Brefel-Courbon, Christine, Ory-Magne, Fabienne, Regis, Jean-Marie, Maltête, David, Sauvaget, Anne, Rau, Jörn, Schnitzler, Alfons, Schüpbach, Michael, Schade-Brittinger, Carmen, Deuschl, Gunther, Houeto, Jean-Luc, and Krack, Paul

Published
2018
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20. Causes of failure of pallidal deep brain stimulation in cases with pre-operative diagnosis of isolated dystonia

Author

Pauls, K. Amande M., Krauss, Joachim K., Kämpfer, Constanze E., Kühn, Andrea A., Schrader, Christoph, Südmeyer, Martin, Allert, Niels, Benecke, Rainer, Blahak, Christian, Boller, Jana K., Fink, Gereon R., Fogel, Wolfgang, Liebig, Thomas, El Majdoub, Faycal, Mahlknecht, Philipp, Kessler, Josef, Mueller, Joerg, Voges, Juergen, Wittstock, Matthias, Wolters, Alexander, Maarouf, Mohammad, Moro, Elena, Volkmann, Jens, Bhatia, Kailash P., and Timmermann, Lars

Published
2017
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23. Predictors of post-stroke depression: Validation of established risk factors and introduction of a dynamic perspective in two longitudinal studies

Author

Ladwig, Simon, Werheid, Katja, Südmeyer, Martin, and Volz, Matthias

Subjects
Psychiatry and Mental health, Schlaganfall, prospective longitudinal, depression, dynamic risk factors, multivariable analysis, Multivariate Analyse, stroke, Risikofaktor
Abstract

IntroductionCerebral insults lead in many cases not only to cognitive impairment but also to disturbed emotionality. After stroke, one in three survivors develops a depression which impacts quality of life and rehabilitation. Meta-analyses have identified five main predictors of post-stroke depression (PSD): history of mental disorder, stroke severity, physical disability, cognitive impairment, and social support. However, these five established variables have never been conjointly investigated in a sample of stroke survivors. Therefore, their independent predictive values remain unclear. Moreover, predictors are most often used as time-invariant factors (status scores), neglecting the intraindividual dynamics after stroke.MethodsOur study analyses the data of two prospective longitudinal studies, investigating stroke survivors from two rehabilitation hospitals (N1 = 273) and one acute care hospital (N2 = 226). Baseline assessments included the five established predictors and depressive symptoms. After 6 months, depressive symptoms were reassessed in both studies (n1 = 176, n2 = 183), and physical disability and social support were reassessed in study 2. The predictivity of the five predictors and the additional predictivity of intraindividual dynamics for PSD were examined in multiple linear regression analyses.ResultsHistory of mental disorder was a risk factor for depressive symptoms after stroke at all measurement times (B = 3.32 to 3.97; p < 0.01). Physical disability was a risk factor at all measurement times (B = −0.09 to −0.03; p < 0.05) except 6 months after rehabilitation. Social support was a protective factor (B = −2.69 to −1.91; p < 0.01) outside the acute phase (R2 = 0.15–0.39). Intraindividual changes in physical disability and perceived social support were independent predictors of PSD 6 months after the acute phase (B = −0.08/−0.14; p < 0.01), in addition to status scores on established variables (ΔR2 = 0.08, p < 0.001).DiscussionHistory of mental disorder, physical disability, and social support are independent predictors of depressive symptoms in the first year post-stroke, also when considered conjointly. Future studies should control for these variables when investigating new predictors of PSD. In addition, intraindividual changes in known predictors after stroke play a relevant role in the pathogenesis of PSD and should be considered in clinical practice and future research.

Published
2023

24. Effects of deep brain stimulation on driving in Parkinson’s disease - a prospective controlled study

Author

Buhmann, Carsten, primary, Fründt, Odette, additional, Mainka, Tina, additional, Vettorazzi, Eik, additional, Baspinar, Ela, additional, Schwarz, Cindy, additional, Südmeyer, Martin, additional, Gerloff, Christian, additional, Zangemeister, Wolfgang, additional, Pötter-Nerger, Monika, additional, Hidding, Ute, additional, Hamel, Wolfgang, additional, and Moll, Christian, additional

Published
2022
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28. Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial

Author

Volkmann, Jens, Mueller, Joerg, Deuschl, Günther, Kühn, Andrea A, Krauss, Joachim K, Poewe, Werner, Timmermann, Lars, Falk, Daniela, Kupsch, Andreas, Kivi, Anatol, Schneider, Gerd-Helge, Schnitzler, Alfons, Südmeyer, Martin, Voges, Jürgen, Wolters, Alexander, Wittstock, Matthias, Müller, Jan-Uwe, Hering, Sascha, Eisner, Wilhelm, Vesper, Jan, Prokop, Thomas, Pinsker, Marcus, Schrader, Christoph, Kloss, Manja, Kiening, Karl, Boetzel, Kai, Mehrkens, Jan, Skogseid, Inger Marie, Ramm-Pettersen, Jon, Kemmler, Georg, Bhatia, Kailash P, Vitek, Jerrold L, and Benecke, Reiner

Published
2014
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30. On the integrity of functional brain networks in schizophrenia, Parkinsonʼs disease, and advanced age: Evidence from connectivity‐based single‐subject classification

Author

Pläschke, Rachel N., Cieslik, Edna C., Müller, Veronika I., Hoffstaedter, Felix, Plachti, Anna, Varikuti, Deepthi P., Goosses, Mareike, Latz, Anne, Caspers, Svenja, Jockwitz, Christiane, Moebus, Susanne, Gruber, Oliver, Eickhoff, Claudia R., Reetz, Kathrin, Heller, Julia, Südmeyer, Martin, Mathys, Christian, Caspers, Julian, Grefkes, Christian, Kalenscher, Tobias, Langner, Robert, and Eickhoff, Simon B.

Published
2017
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32. Impact of COVID-19 Pandemic on (Health) Care Situation of People with Parkinson’s Disease in Germany (Care4PD)

Author

Fründt, Odette, Hanff, Anne-Marie, Mai, Tobias, Kirchner, Christiane, Bouzanne des Mazery, Emma, Amouzandeh, Ali, Buhmann, Carsten, Krüger, Rejko, Südmeyer, Martin, Fründt, Odette, Hanff, Anne-Marie, Mai, Tobias, Kirchner, Christiane, Bouzanne des Mazery, Emma, Amouzandeh, Ali, Buhmann, Carsten, Krüger, Rejko, and Südmeyer, Martin

Abstract

The Care4PD study examined the impact of the COVID-19 pandemic on the care situation of people (PwP) with Parkinson’s disease in Germany. A comprehensive, nationwide, anonymous questionnaire for PwP was distributed by the members’ journal of the German Parkinson’s Disease Association and in several PD specialized in- and outpatient institutions. PwP subjectively evaluated their general care situation and individual impairments during the pandemic. We analyzed 1269 eligible out of 1437 returned questionnaires (88.3%) and compared PwP with (p-LTC) and without (np-LTC) professional long-term care. Both groups rated the general pandemic-related consequences as being rather mild to moderate (e.g., worsening of symptom or concerns). However, familial/social contact restrictions were indicated as most compromising, whereas access to outpatient professional health care providers was less affected. PwP with professional LTC reported more impairment than those without. COVID-19 vaccination rates and acceptance were generally high (p-LTC: 64.3%, np-LTC: 52.3%) at the time of the study, but realization of sanitary measures—especially wearing masks as a patient during care sessions—still needs to be improved. Technical options for telemedicine were principally available but only rarely used. Altogether, during the COVID-19 pandemic, PwP in Germany seemed to have a relatively stable health care access, at least in outpatient settings, while mainly social isolation compromised them. The p-LTC group was more impaired in everyday live compared with the np-LTC group.

Published
2022

34. Device-Aided Therapies in Parkinson's Disease—Results from the German Care4PD Study.

Author

Fründt, Odette, Hanff, Anne-Marie, Möhl, Annika, Mai, Tobias, Kirchner, Christiane, Amouzandeh, Ali, Buhmann, Carsten, Krüger, Rejko, and Südmeyer, Martin

Subjects
PARKINSON'S disease, DEEP brain stimulation, INFUSION therapy
Abstract

Data on the use of device-aided therapies (DATs) in people with Parkinson's disease (PwP) are scarce. Analyzing data from the Care4PD patient survey, we (1) evaluated application frequency and type of DAT in a larger, nationwide, cross-sectoral PwP sample in Germany; (2) analyzed the frequency of symptoms indicative for advanced PD (aPD) and need for DAT amongst the remaining patients and (3) compared the most bothersome symptoms and need for professional long-term care (LTC) of patients with and without suspected aPD. Data from 1269 PwP were analyzed. In total, 153 PwP (12%) received DAT, mainly deep brain stimulation (DBS). Of the remaining 1116 PwP without DAT, >50% fulfilled at least one aPD criterion. Akinesia/rigidity and autonomic problems were most bothersome for PwP with and without suspected aPD, with more tremor in the non-aPD and more motor fluctuations and falls in the aPD group. To recapitulate, the German DAT application rate is rather low, although a large proportion of PwP fulfills aPD criteria indicating a need for intensified treatment strategies. Many reported bothersome symptoms could be overcome with DAT with benefits even for LTC patients. Thus, precise and early identification of aPD symptoms (and therapy-resistant tremor) should be implemented in future DAT preselection tools and educational trainings. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Increased sensory feedback in Tourette syndrome

Author

Biermann-Ruben, Katja, Miller, Anastasia, Franzkowiak, Stephanie, Finis, Jennifer, Pollok, Bettina, Wach, Claudia, Südmeyer, Martin, Jonas, Melanie, Thomalla, Götz, Müller-Vahl, Kirsten, Münchau, Alexander, and Schnitzler, Alfons

Published
2012
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47. Erratum to: The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach

Author

Levin, Johannes, Maaß, Sylvia, Schuberth, Madeleine, Respondek, Gesine, Paul, Friedemann, Mansmann, Ullrich, Oertel, Wolfgang H., Lorenzl, Stefan, Krismer, Florian, Seppi, Klaus, Poewe, Werner, Wenning, Gregor, Berg, D., Claßen, Joseph, Ebersbach, Georg, Eggert, Karla, Kassubek, Jan, Lipp, Axel, Löhle, Matthias, Mollenhauer, Brit, Münchau, Alexander, Südmeyer, Martin, Blankenstein, C., Eberhardt, C., Ertl-Wagner, B., Heise, H., Ricard, I., Giese, Armin, Bötzel, Kai, Höglinger, Günter, and The PROMESA study group

Published
2016
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48. Comparative Analysis of Machine Learning Algorithms for Multi-Syndrome Classification of Neurodegenerative Syndromes

Author

Lampe, Leonie, primary, Niehaus, Sebastian, additional, Huppertz, Hans-Jürgen, additional, Merola, Alberto, additional, Reinelt, Janis, additional, Mueller, Karsten, additional, Anderl-Straub, Sarah, additional, Fassbender, Klaus, additional, Fliessbach, Klaus, additional, Jahn, Holger, additional, Kornhuber, Johannes, additional, Lauer, Martin, additional, Prudlo, Johannes, additional, Schneider, Anja, additional, Synofzik, Matthis, additional, Danek, Adrian, additional, Diehl-Schmid, Janine, additional, Otto, Markus, additional, Villringer, Arno, additional, Egger, Karl, additional, Hattingen, Elke, additional, Hilker-Roggendorf, Rüdiger, additional, Schnitzler, Alfons, additional, Südmeyer, Martin, additional, Oertel, Wolfgang, additional, Kassubek, Jan, additional, Höglinger, Günther, additional, and Schroeter, Matthias L., additional

Published
2021
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