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7. NatIonal Danish endocarditis stUdieS – Design and objectives of the NIDUS registry

Author

Graversen, Peter L., Hadji-Turdeghal, Katra, Møller, Jacob Eifer, Bruun, Niels Eske, Laghmoch, Hicham, Jensen, Andreas Dalsgaard, Petersen, Jeppe K., Bundgaard, Henning, Iversen, Kasper, Povlsen, Jonas A., Moser, Claus, Smerup, Morten, Jensen, Hanne Sortsøe, Søgaard, Peter, Helweg-Larsen, Jannik, Faurholt-Jepsen, Daniel, Østergaard, Lauge, Køber, Lars, and Fosbøl, Emil L.

Published
2024
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14. Does targeted positioning of the left ventricular pacing lead towards the latest local electrical activation in cardiac resynchronization therapy reduce the incidence of death or hospitalization for heart failure?

Author

Kronborg, Mads Brix, Frausing, Maria Hee Jung Park, Svendsen, Jesper Hastrup, Johansen, Jens Brock, Riahi, Sam, Haarbo, Jens, Poulsen, Steen Hvitfeldt, Eiskjær, Hans, Køber, Lars, Øvrehus, Kristian, Sommer, Anders Munck, Schou, Morten, Nørgaard, Bjarne Linde, Risum, Niels, Poulsen, Mikael Kjær, Søgaard, Peter, Sandgaard, Niels, Kofoed, Klaus F., Hansen, Thomas Fritz, Graff, Claus, Pedersen, Susanne S, Skals, Regitze Gyldenholm, and Nielsen, Jens Cosedis

Published
2023
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16. Electrocardiographic P terminal force in lead V1, its components, and the association with stroke and atrial fibrillation or flutter

Author

Wolder, Lecia Dixen, Graff, Claus, Baadsgaard, Kirstine H., Langgaard, Monica Lykke, Polcwiartek, Christoffer, Ji-Young Lee, Christina, Skov, Morten Wagner, Torp-Pedersen, Christian, Friedman, Daniel J., Atwater, Brett, Overvad, Thure Filskov, Nielsen, Jonas Bille, Hansen, Steen Moeller, Sogaard, Peter, and Kragholm, Kristian H.

Published
2023
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18. Arrhythmia monitoring and outcome after myocardial infarction (BIO|GUARD-MI): a randomized trial

Author

Jøns, Christian, primary, Bloch Thomsen, Poul Erik, additional, Riahi, Sam, additional, Smilde, Tom, additional, Bach, Ulrich, additional, Jacobsen, Peter Karl, additional, Táborský, Miloš, additional, Faluközy, Jozsef, additional, Wiemer, Marcus, additional, Christensen, Per Dahl, additional, Kónyi, Attila, additional, Schelfaut, Dan, additional, Bulava, Alan, additional, Grabowski, Marcin, additional, Merkely, Béla, additional, Nuyens, Dieter, additional, Mahajan, Rajiv, additional, Nagel, Patrick, additional, Tilz, Roland, additional, Malczynski, Jerzy, additional, Steinwender, Clemens, additional, Brachmann, Johannes, additional, Serota, Harvey, additional, Schrader, Jürgen, additional, Behrens, Steffen, additional, and Søgaard, Peter, additional

Published
2024
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20. Increased preload and echocardiographic assessment of diastolic function.

Author

Taraldsen, Ida Arentz, Mogelvang, Rasmus, Grund, Frederik Fasth, Hassager, Christian, Søgaard, Peter, and Kristensen, Charlotte Burup

Subjects
T-test (Statistics), DATA analysis, FISHER exact test, HEMODIALYSIS, MANN Whitney U Test, CHI-squared test, DESCRIPTIVE statistics, CARDIAC output, LONGITUDINAL method, DIASTOLIC blood pressure, STATISTICS, PATIENT monitoring, DATA analysis software, HEART ventricles, ECHOCARDIOGRAPHY, LEFT ventricular dysfunction, REGRESSION analysis
Abstract

Aims: Echocardiographic diastolic parameters are used to diagnose and monitor increased left ventricular filling pressure (LVFP) and we hypothesized that increased loading conditions cause increased E/e′. Our aim was to assess the effect of preload augmentation on diastolic parameters among both healthy subjects and subjects with known cardiac disease. Methods and results: We included 129 subjects merged from two cohorts; one dialysis cohort (n = 47) and one infusion cohort (n = 82). Echocardiography was performed immediately before and after hemodialysis (HD) or saline infusion, under low and high loading conditions. Elevated LVFP was defined as septal E/e′ ≥ 15 and/or lateral E/e′ ≥ 13 at high‐loading conditions. The population was divided according to elevated LVFP (n = 31) and normal LVFP (n = 98). The load difference for the population was 972 ± 460 mL, with no differences in load difference between elevated and normal LVFP (p NS). The subjects with elevated LVFP were older (63 ± 11 vs. 46 ± 16 years, p <.001), and had lower LV ejection fraction (50 ± 14 vs. 59 ± 8.1%, p <.01). After augmented preload, EDV increased in the normal LVFP group (p <.01) but remained unchanged in the elevated LVFP group (p NS). Both E and e′ increased among the subjects with normal LVFP, whereas E/e′ remained unchanged (∆E/e′ +.1 [‐.5–1.2]), p NS). Among the subjects with elevated, LVFP we observed increased E but not e′, resulting in significantly increased E/e′ (∆ average E/e′ +2.4 [0–4.0], p <.01). Conclusion: Augmented preload does not seem to affect E/e′ among subjects with normal LVFP, whereas E/e′ seems to increase significantly among subjects with elevated LVFP. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study

Author

Shanmuganathan, Jan Walter Dhillon, Kragholm, Kristian, Tayal, Bhupendar, Polcwiartek, Christoffer, Poulsen, Laurids Østergaard, El-Galaly, Tarec Christoffer, Fosbøl, Emil Loldrup, D’Souza, Maria, Gislason, Gunnar, Køber, Lars, Schou, Morten, Nielsen, Dorte, Søgaard, Peter, Torp-Pedersen, Christian Tobias, Mamas, Mamas A., and Freeman, Phillip

Published
2021
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22. at onal anish endocarditis st die – Design and objectives of the NIDUS registry

Author

Graversen, Peter L., primary, Hadji-Turdeghal, Katra, additional, Møller, Jacob Eifer, additional, Bruun, Niels Eske, additional, Laghmoch, Hicham, additional, Jensen, Andreas Dalsgaard, additional, Petersen, Jeppe K., additional, Bundgaard, Henning, additional, Iversen, Kasper, additional, Povlsen, Jonas A., additional, Moser, Claus, additional, Smerup, Morten, additional, Jensen, Hanne Sortsøe, additional, Søgaard, Peter, additional, Helweg-Larsen, Jannik, additional, Faurholt-Jepsen, Daniel, additional, Østergaard, Lauge, additional, Køber, Lars, additional, and Fosbøl, Emil L., additional

Published
2024
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25. Aortic Root Dimension Using Transthoracic Echocardiography:Results from the Copenhagen City Heart Study

Author

Pedersen, Maria W., Duch, Kirsten, Lindgren, Filip L., Lundgren, Nils L.O., Tayal, Bhupendar, Hagendorff, Andreas, Jensen, Gorm B., Biering-Sørensen, Tor, Schnohr, Peter, Møgelvang, Rasmus, Høst, Nis, Kragholm, Kristian, Andersen, Niels H., Søgaard, Peter, Pedersen, Maria W., Duch, Kirsten, Lindgren, Filip L., Lundgren, Nils L.O., Tayal, Bhupendar, Hagendorff, Andreas, Jensen, Gorm B., Biering-Sørensen, Tor, Schnohr, Peter, Møgelvang, Rasmus, Høst, Nis, Kragholm, Kristian, Andersen, Niels H., and Søgaard, Peter

Abstract

Findings regarding the relation between aortic size and risk factors are heterogeneous. This study aimed to generate new insights from a population-based adult cohort on aortic root dimensions and their association with age, anthropometric measures, and cardiac risk factors and evaluate the incidence of acute aortic events. Participants from the fifth examination round of the Copenhagen City Heart study (aged 20 to 98 years) with applicable echocardiograms and no history of aortic disease or valve surgery were included. Aorta diameter was assessed at the annulus, sinus of Valsalva, sinotubular junction, and the tubular part of the ascending aorta. The study population comprised 1,796 men and 2,316 women; mean age: 56.4 ± 17.0 and 56.9 ± 18.1 years, respectively. Men had larger aortic root diameters than women regardless of height indexing (p <0.01). Age, height, weight, systolic and diastolic blood pressure, mean arterial pressure, pulse pressure, hypertension, diabetes, ischemic heart disease, and smoking were positively correlated with aortic sinus diameter in the crude and gender-adjusted analyses. However, after full adjustment, only height, weight, and diastolic blood pressure remained significantly positively correlated with aortic sinus diameter (p <0.001). For systolic blood pressure and pulse pressure, the correlation was inverse (p <0.001). During follow-up (median 5.4 [quartile 1 to quartile 3 4.5 to 6.3] years), the incidence rate of first-time acute aortic events was 13.6 (confidence interval 4.4 to 42.2) per 100,000 person-years. In conclusion, beyond anthropometric measures, age, and gender, diastolic blood pressure was the only cardiac risk factor that was independently correlated with aortic root dimensions. The number of aortic events during follow-up was low.

Published
2024

26. Normal Values for Left Atrial Strain, Volume and Function Derived from Three-Dimensional Echocardiography:the Copenhagen City Heart Study

Author

Yafasov, Marat, Olsen, Flemming Javier, Skaarup, Kristoffer Grundtvig, Lassen, Mats Christian Højbjerg, Johansen, Niklas Dyrby, Lindgren, Filip Lyng, Jensen, Gorm Boje, Schnohr, Peter, Møgelvang, Rasmus, Søgaard, Peter, Biering-Sørensen, Tor, Yafasov, Marat, Olsen, Flemming Javier, Skaarup, Kristoffer Grundtvig, Lassen, Mats Christian Højbjerg, Johansen, Niklas Dyrby, Lindgren, Filip Lyng, Jensen, Gorm Boje, Schnohr, Peter, Møgelvang, Rasmus, Søgaard, Peter, and Biering-Sørensen, Tor

Abstract

Aims 3D echocardiographic (3DE) assessment of the left atrium (LA) is a new modality of potential clinical value. Age- and sex-based normative values are needed to benchmark these parameters for clinical use. Methods and results Of 4466 participants in the 5th Copenhagen City Heart Study, a prospective longitudinal cohort study on the general population, 2082 participants underwent 3DE of the LA. Healthy participants were included to establish normative values for LA strain, volume, and function by 3DE. The effects of age and sex were also evaluated. After excluding participants with comorbidities, 979 healthy participants (median age 44 years, 39.6% males) remained. The median and limits of normality (2.5th and 97.5th percentiles) for functional and volumetric measures were as follows: LA reservoir strain (LASr) 30.8% (18.4–44.2%), LA conduit strain (LAScd) 19.1% (6.8–32.0%), LA contractile strain 11.7% (4.3–22.2%), total LA emptying fraction (LAEF) 61.4% (47.8–71.0%), passive LAEF 37.7% (17.4–53.9%), active LAEF 37.4% (22.2–52.5%), LA minimum volume index (LAVimin) 10.2 (5.9–18.5) mL/m2, and LA maximum volume index (LAVimax) 26.8 (16.5–40.1) mL/m2. All parameters changed significantly with increasing age (P value for all <0.001). Significant sex-specific differences were observed for all parameters except active LAEF and LAVimax. Sex significantly modified the association between age and LASr (P for interaction < 0.001), LAScd (P for interaction < 0.001), LAVimin (P for interaction = 0.037), and total LAEF (P for interaction = 0.034) such that these parameters deteriorated faster with age in females than males. Conclusion We present age- and sex-specific reference material including limits of normality for LA strain, volume, and function by 3DE., BACKGROUND: Three-dimensional echocardiographic (3DE) assessment of the left atrium (LA) is a new modality of potential clinical value. Age- and sex-based normative values are needed to benchmark these parameters for clinical use.METHODS AND RESULTS: Of 4466 participants in the 5th Copenhagen City Heart Study, a prospective longitudinal cohort study on the general population, 2,082 participants underwent 3DE of the LA. Healthy participants were included to establish normative values for LA strain, volume, and function by 3DE. The effects of age and sex were also evaluated. After excluding participants with comorbidities, 979 healthy participants (median age 44 years, 39.6% males) remained. The median and limits of normality (2.5th and 97.5th percentiles) for functional and volumetric measures were: LA reservoir strain (LASr) 30.8% (18.4-44.2%), LA conduit strain (LAScd) 19.1% (6.8-32.0%), LA contractile strain (LASct) 11.7% (4.3-22.2%) total LA emptying fraction (LAEF) 61.4% (47.8-71.0%), passive LAEF 37.7% (17.4-53.9%), active LAEF 37.4% (22.2-52.5%), LA minimum volume index (LAVimin) 10.2 (5.9-18.5) ml/m2, LA maximum volume index (LAVimax) 26.8 (16.5-40.1) ml/m2. All parameters changed significantly with increasing age (p value for all <0.001). Significant sex-specific differences were observed for all parameters except active LAEF and LAVimax. Sex significantly modified the association between age and LASr (p for interaction < 0.001), LAScd (p for interaction < 0.001), LAVimin (p for interaction = 0.037) and total LAEF (p for interaction = 0.034) such that these parameters deteriorated faster with age in females than males.CONCLUSION: We present age- and sex specific reference material including limits of normality for LA strain, volume, and function by 3DE.

Published
2024

27. Association between myocardial work indices and cardiovascular events according to hypertension in the general population

Author

Olsen, Flemming Javier, Skaarup, Kristoffer Grundtvig, Lassen, Mats Christian Højbjerg, Johansen, Niklas Dyrby, Jensen, Gorm Boje, Schnohr, Peter, Marott, Jacob Louis, Søgaard, Peter, Gislason, Gunnar, Svendsen, Jesper Hastrup, Møgelvang, Rasmus, Aalen, John Moene, Smiseth, Otto Armin, Remme, Espen Wattenberg, Biering-Sørensen, Tor, Olsen, Flemming Javier, Skaarup, Kristoffer Grundtvig, Lassen, Mats Christian Højbjerg, Johansen, Niklas Dyrby, Jensen, Gorm Boje, Schnohr, Peter, Marott, Jacob Louis, Søgaard, Peter, Gislason, Gunnar, Svendsen, Jesper Hastrup, Møgelvang, Rasmus, Aalen, John Moene, Smiseth, Otto Armin, Remme, Espen Wattenberg, and Biering-Sørensen, Tor

Abstract

Aims Pressure-strain loop (PSL) analysis is a novel echocardiographic tool capable of assessing myocardial work non-invasively. In this study, we aim to evaluate the prognostic value of myocardial work indices in the general population. Methods and results This was a prospective community-based cohort study (n = 4466). PSL analyses were performed to acquire global work index (GWI), global constructive work (GCW), global wasted work, and global work efficiency (GWE). The endpoint was a composite of heart failure or cardiovascular death (HF/CVD). Survival analysis was applied. A total of 3932 participants were included in this analysis (median age: 58 years, 43% men). Of these, 124 (3%) experienced the outcome during a median follow-up period of 3.5 years [interquartile range (IQR): 2.6–4.4 years]. Hypertension significantly modified the association between all work indices and outcome (P for interaction < 0.05), such that work indices posed a higher risk of outcome in non-hypertensive than in hypertensive participants. After adjusting for Atherosclerosis Risk in Communities (ARIC)-HF risk variables, all work indices predicted outcome in non-hypertensive participants, but only GWI, GCW, and GWE predicted outcome in hypertensive participants [GWI: hazard ratio (HR) = 1.12 (1.07–1.16), per 100 mmHg% decrease; GCW: HR = 1.12 (1.08–1.17), per 100 mmHg% decrease; GWE: HR = 1.08 (1.04–1.12), per 1% decrease]. Only GWE significantly increased C-statistics when added to ARIC-HF risk variables in hypertensive participants (C-stat 0.865 vs. 0.877, P for increment = 0.003). Conclusion Hypertension modifies the association between myocardial work indices and HF/CVD in the general population. All work indices are associated with outcome in normotensive participants. GWI, GCW, and GWE are independently associated with outcome in hypertension, but only GWE improves risk prediction., AIMS: Pressure-strain loop (PSL) analysis is a novel echocardiographic tool capable of assessing myocardial work non-invasively. In this study, we aim to evaluate the prognostic value of myocardial work indices in the general population.METHODS AND RESULTS: This was a prospective community-based cohort study (n = 4466). PSL analyses were performed to acquire global work index (GWI), global constructive work (GCW), global wasted work, and global work efficiency (GWE). The endpoint was a composite of heart failure or cardiovascular death (HF/CVD). Survival analysis was applied. A total of 3932 participants were included in this analysis (median age: 58 years, 43% men). Of these, 124 (3%) experienced the outcome during a median follow-up period of 3.5 years [interquartile range (IQR): 2.6-4.4 years]. Hypertension significantly modified the association between all work indices and outcome (P for interaction < 0.05), such that work indices posed a higher risk of outcome in non-hypertensive than in hypertensive participants. After adjusting for Atherosclerosis Risk in Communities (ARIC)-HF risk variables, all work indices predicted outcome in non-hypertensive participants, but only GWI, GCW, and GWE predicted outcome in hypertensive participants [GWI: hazard ratio (HR) = 1.12 (1.07-1.16), per 100 mmHg% decrease; GCW: HR = 1.12 (1.08-1.17), per 100 mmHg% decrease; GWE: HR = 1.08 (1.04-1.12), per 1% decrease]. Only GWE significantly increased C-statistics when added to ARIC-HF risk variables in hypertensive participants (C-stat 0.865 vs. 0.877, P for increment = 0.003).CONCLUSION: Hypertension modifies the association between myocardial work indices and HF/CVD in the general population. All work indices are associated with outcome in normotensive participants. GWI, GCW, and GWE are independently associated with outcome in hypertension, but only GWE improves risk prediction.

Published
2024

30. Normal values for left atrial strain, volume, and function derived from 3D echocardiography: the Copenhagen City Heart Study.

Author

Yafasov, Marat, Olsen, Flemming Javier, Skaarup, Kristoffer Grundtvig, Lassen, Mats Christian Højbjerg, Johansen, Niklas Dyrby, Lindgren, Filip Lyng, Jensen, Gorm Boje, Schnohr, Peter, Møgelvang, Rasmus, Søgaard, Peter, and Biering-Sørensen, Tor

Subjects
REFERENCE values, PEARSON correlation (Statistics), LEFT heart atrium, RESEARCH funding, BENCHMARKING (Management), SEX distribution, KRUSKAL-Wallis Test, AGE distribution, CHI-squared test, MULTIVARIATE analysis, DESCRIPTIVE statistics, LONGITUDINAL method, DISEASES, DATA analysis software, ECHOCARDIOGRAPHY, REGRESSION analysis
Abstract

Aims 3D echocardiographic (3DE) assessment of the left atrium (LA) is a new modality of potential clinical value. Age- and sex-based normative values are needed to benchmark these parameters for clinical use. Methods and results Of 4466 participants in the 5th Copenhagen City Heart Study, a prospective longitudinal cohort study on the general population, 2082 participants underwent 3DE of the LA. Healthy participants were included to establish normative values for LA strain, volume, and function by 3DE. The effects of age and sex were also evaluated. After excluding participants with comorbidities, 979 healthy participants (median age 44 years, 39.6% males) remained. The median and limits of normality (2.5th and 97.5th percentiles) for functional and volumetric measures were as follows: LA reservoir strain (LASr) 30.8% (18.4–44.2%), LA conduit strain (LAScd) 19.1% (6.8–32.0%), LA contractile strain 11.7% (4.3–22.2%), total LA emptying fraction (LAEF) 61.4% (47.8–71.0%), passive LAEF 37.7% (17.4–53.9%), active LAEF 37.4% (22.2–52.5%), LA minimum volume index (LAVimin) 10.2 (5.9–18.5) mL/m2, and LA maximum volume index (LAVimax) 26.8 (16.5–40.1) mL/m2. All parameters changed significantly with increasing age (P value for all <0.001). Significant sex-specific differences were observed for all parameters except active LAEF and LAVimax. Sex significantly modified the association between age and LASr (P for interaction < 0.001), LAScd (P for interaction < 0.001), LAVimin (P for interaction = 0.037), and total LAEF (P for interaction = 0.034) such that these parameters deteriorated faster with age in females than males. Conclusion We present age- and sex-specific reference material including limits of normality for LA strain, volume, and function by 3DE. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Normal Values for Myocardial Work Indices Derived From Pressure-Strain Loop Analyses: From the CCHS

Author

Olsen, Flemming Javier, Skaarup, Kristoffer Grundtvig, Lassen, Mats Christian Højbjerg, Johansen, Niklas Dyrby, Sengeløv, Morten, Jensen, Gorm Boje, Schnohr, Peter, Marott, Jacob Louis, Søgaard, Peter, Gislason, Gunnar, Svendsen, Jesper Hastrup, Møgelvang, Rasmus, Aalen, John Moene, Remme, Espen Wattenberg, Smiseth, Otto Armin, and Biering-Sørensen, Tor

Published
2022
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36. Contractile Asymmetry and Survival in Patients with Left Bundle Branch Block Treated with Cardiac Resynchronization Therapy

Author

Kader, Nareen, primary, Holm-Nielsen, Liv Therese, additional, Tayal, Bhupendar, additional, Riahi, Sam, additional, Sommer, Anders, additional, Nielsen, Jens Cosedis, additional, Kronborg, Mads Brix, additional, Stephansen, Charlotte, additional, Andersen, Niels Holmark, additional, Risum, Niels, additional, Søgaard, Peter, additional, and Zaremba, Tomas, additional

Published
2023
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37. Association between myocardial work indices and cardiovascular events according to hypertension in the general population

Author

Olsen, Flemming Javier, primary, Skaarup, Kristoffer Grundtvig, additional, Lassen, Mats Christian Højbjerg, additional, Johansen, Niklas Dyrby, additional, Jensen, Gorm Boje, additional, Schnohr, Peter, additional, Marott, Jacob Louis, additional, Søgaard, Peter, additional, Gislason, Gunnar, additional, Svendsen, Jesper Hastrup, additional, Møgelvang, Rasmus, additional, Aalen, John Moene, additional, Smiseth, Otto Armin, additional, Remme, Espen Wattenberg, additional, and Biering-Sørensen, Tor, additional

Published
2023
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45. Education level and the use of coronary computed tomography, functional testing, coronary angiography, revascularization, and outcomes—a 10-year Danish, nationwide, registry-based follow-up study

Author

Søndergaard, Marc Meller, Freeman, Phillip, Kristensen, Anna Meta Dyrvig, Chang, Su Min, Nassir, Khurram, Mortensen, Martin Bødtker, Nørgaard, Bjarne Linde, Maeng, Michael, Andersen, Mikkel Porsborg, Søgaard, Peter, Tayal, Bhupendar, Pareek, Manan, Johnsen, Søren Paaske, Køber, Lars, Gislason, Gunnar, Torp-Pedersen, Christian, and Kragholm, Kristian Hay

Published
2024
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48. Trends in Medical and Device Therapies Following Incident Heart Failure in Denmark during 1996–2019: A Nationwide Register-Based Follow-Up Study

Author

Ettrup-Christensen, Asbjørn, primary, Butt, Jawad H., additional, Andersen, Mikkel Porsborg, additional, Sessa, Maurizio, additional, Polcwiartek, Christoffer, additional, Fosbøl, Emil L., additional, Rørth, Rasmus, additional, Kristensen, Søren L., additional, Torp-Pedersen, Christian, additional, Køber, Lars, additional, Schou, Morten, additional, Tayal, Bhupendar, additional, Søgaard, Peter, additional, and Kragholm, Kristian, additional

Published
2023
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