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1,144 results on '"Søborg A"'

1. The changing landscape of acromegaly – an epidemiological perspective

Author: Rosendal, Christian, Arlien-Søborg, Mai Christiansen, Nielsen, Eigil Husted, Andersen, Marianne Skovsager, Feltoft, Claus Larsen, Kistorp, Caroline, Dekkers, Olaf M., Jørgensen, Jens Otto Lunde, and Dal, Jakob
Published: 2024
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2. The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11: the Danish high risk and resilience study

Author: Andreassen, Anna Krogh, Lambek, Rikke, Greve, Aja, Hemager, Nicoline, Knudsen, Christina Bruun, Veddum, Lotte, Birk, Merete, Søndergaard, Anne, Brandt, Julie Marie, Gregersen, Maja, Falkenberg-Krantz, Mette, Spang, Katrine Søborg, Ohland, Jessica, Burton, Birgitte Klee, Jepsen, Jens Richardt Møllegaard, Thorup, Anne Amalie Elgaard, Nordentoft, Merete, Mors, Ole, and Bliksted, Vibeke Fuglsang
Published: 2024
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3. Relative vaccine protection, disease severity, and symptoms associated with the SARS-CoV-2 omicron subvariant BA.2.86 and descendant JN.1 in Denmark: a nationwide observational study

Author: Christiansen, Lasse Engbo, Gubbels, Sophie, Trebbien, Ramona, Westergaard, Casper, Escobar-Herrera, Leandro Andrés, Gunalan, Vithiagaran, Ring, Aleksander, Bennedbæk, Marc, Steenhard, Nina, Mørk Hartmann, Esben, Nielsen, Lene, Terp Andersen, Dorte, Thomsen, Marianne Kragh, Marmolin, Ea Sofie, Vognbjerg Sydenham, Thomas, Hoegh, Silje Vermedal, Pinholt, Mette, Møller, Josefine Tange, Vasehus Madsen, Tina, Fuglsang-Damgaard, David, Jokelainen, Pikka, Krause, Tyra Grove, Ullum, Henrik, Søborg, Bolette, Valentiner-Branth, Palle, Moustsen-Helms, Ida Rask, Bager, Peter, Larsen, Tine Graakjær, Møller, Frederik Trier, Vestergaard, Lasse Skafte, Rasmussen, Morten, and Hansen, Christian Holm
Published: 2024
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4. Production of 67Cu at a biomedical cyclotron via 70Zn(p,α)67Cu reaction and its evaluation in a preclinical study using small animal SPECT/CT

Author: Søndergaard, Ursula, Thomas, Kolle E., Søborg Pedersen, Kristina, Kranz, Mathias, Sundset, Rune, Moldes-Anaya, Angel, and Jensen, Mikael
Published: 2025
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5. Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Author: Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. Duncan, Terndrup, Thomas E., Wiedemann, Herbert P., Hudock, Kristin, Tanzeem, Hammad, More, Harshada, Martinkovic, Jamie, Sellers, Susan, Houston, Judy, Burns, Mary, Kiran, Simra, Roads, Tammy, Kennedy, Sarah, Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Dugar, Siddharth, Sahoo, Debasis, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra J., Vita, Tina M., Berryman, Emily, Hough, Catherine L., Khan, Akram, Krol, Olivia F., Mills, Emmanuel, Kinjal, Mistry, Briceno, Genesis, Reddy, Raju, Hubel, Kinsley, Jouzestani, Milad K., McDougal, Madeline, Deshmukh, Rupali, Johnston, Nicholas J., Robinson, Bryce H., Gundel, Staphanie J., Katsandres, Sarah C., Chen, Peter, Torbati, Sam S., Parimon, Tanyalak, Caudill, Antonina, Mattison, Brittany, Jackman, Susan E., Chen, Po-En, Bayoumi, Emad, Ojukwu, Cristabelle, Fine, Devin, Weissberg, Gwendolyn, Isip, Katherine, Choi-Kuaea, Yunhee, Mehdikhani, Shaunt, Dar, Tahir B., Fleury Augustin, Nsole Biteghe, Tran, Dana, Dukov, Jennifer Emilow, Matusov, Yuri, Choe, June, Hindoyan, Niree A., Wynter, Timothy, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Caudill, Antonia, O’Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Duven, Alexandria M., Fletcher, Dakota D., Miller, Chadwick, Files, D. Clark, Gibbs, Kevin W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Palacios, D. Rafael, Parks, Lisa, Hicks, Madeline, Goodwin, Andrew J., Kilb, Edward F., Lematty, Caitlan T., Patti, Kerilyn, Grady, Abigail, Rasberry, April, Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sarah N., Mayer, Kirby P., Pharm.D., Brittany Bissel, Trott, Terren, Rehman, Shahnaz, de Wit, Marjolein, Mason, Jessica, Bledsoe, Joseph, Knowlton, Kirk U., Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Pelton, Ithan, Armbruster, Brent P., Montgomery, Quinn, Kumar, Naresh, Fergus, Melissa, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Klippel, Carolyn, Jensen, Hannah, Duckworth, Sarah, Gray, Andrew, Burke, Tyler, Knox, Dan, Lumpkin, Jenna, Aston, Valerie T., Applegate, Darrin, Serezlic, Erna, Brown, Katie, Merril, Mardee, Harris, Estelle S., Middleton, Elizabeth A., Barrios, Macy A.G., Greer, Jorden, Schmidt, Amber D., Webb, Melissa K., Paine, Roert, Callahan, Sean J., Waddoups, Lindsey J., Yamane, Misty B., Self, Wesley H., Rice, Todd W., Casey, Jonathan D., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Menon, Vidya, Kasubhai, Moiz, Pillai, Anjana, Daniel, Jean, Sittler, Daniel, Kanna, Balavenkatesh, Jilani, Nargis, Amaro, Francisco, Santana, Jessica, Lyakovestsky, Aleksandr, Madhoun, Issa, Desroches, Louis Marie, Amadon, Nicole, Bahr, Alaa, Ezzat, Imaan, Guerrero, Maryanne, Padilla, Joane, Fullmer, Jessie, Singh, Inderpreet, Ali Shah, Syed Hamad, Narang, Rajeev, Mock, Polly, Shadle, Melissa, Hernandez, Brenda, Welch, Kevin, Payne, Andrea, Ertl, Gabriela, Canario, Daniel, Barrientos, Isabel, Goss, Danielle, DeVries, Mattie, Folowosele, Ibidolapo, Garner, Dorothy, Gomez, Mariana, Price, Justin, Bansal, Ekta, Wong, Jim, Faulhaber, Jason, Fazili, Tasaduq, Yeary, Brian, Ndolo, Ruth, Bryant, Christina, Smigeil, Bridgette, Robinson, Philip, Najjar, Rana, Jones, Patrice, Nguyen, Julie, Chin, Christina, Taha, Hassan, Najm, Salah, Smith, Christopher, Moore, Jason, Nassar, Talal, Gallinger, Nick, Christian, Amy, Mauer, D’Amber, Phipps, Ashley, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Landazuri, Rosalynn, Pineda, Jacob, Uribe, Nicole, Garcia, Jose Ruiz, Barbabosa, Cecilia, Sandler, Kaitlyn, Overcash, J. Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, Swiderek, Jennifer, Gupta, Ariella Hodari, Pabla, Pardeep, Eliya, Sonia, Jazrawi, Jehan, Delor, Jeremy, Desai, Mona, Cook, Aaron, Jaehne, Anja Kathrina, Gill, Jasreen Kaur, Renaud, Sheri, Sarveswaran, Siva, Gardner, Edward, Scott, James, Bianchini, Monica, Melvin, Casey, Kim, Gina, Wyles, David, Kamis, Kevin, Miller, Rachel, Douglas, Ivor, Haukoos, Jason, Hicks, Carrie, Lazarte, Susana, Marines-Price, Rubria, Osuji, Alice, Agbor Agbor, Barbine Tchamba, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Garcia, Angie, Cha, Christine, Mozaffari, Azadeh, Hernandez, Rosa, Cutrell, James, Kim, Mina, DellaValle, Natalie, Gonzales, Sonia, Somboonwit, Charurut, Oxner, Asa, Guerra, Lucy, Hayes, Michael, Nguyen, Thi, Tran, Thanh, Pinto, Avenette, Hatlen, Timothy, Anderson, Betty, Zepeda-Gutierrez, Ana, Martin, Dannae, Temblador, Cindi, Cuenca, Avon, Tanoviceanu, Roxanne, Prieto, Martha, Guerrero, Mario, Daar, Eric, Correa, Ramiro, Hartnell, Gabe, Wortmann, Glenn, Doshi, Saumil, Moriarty, Theresa, Gonzales, Melissa, Garman, Kristin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Driver, Brian, Frank, Christine, Leviton, Tzivia, Prekker, Matthew, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Kunisaki, Ken M., Wendt, Chris, Melzer, Anne, Wetherbee, Erin, Drekonja, Dimitri, Pragman, Alexa, Hamel, Aimee, Thielen, Abbie, Hassler, Miranda, Walquist, Mary, Augenbraun, Michael, George, Jensen, Demeo, Lynette, Mishko, Motria, Thomas, Lorraine, Tatem, Luis, Dehovitz, Jack, Abassi, Mahsa, Leuck, Anne-Marie, Rao, Via, Pullen, Matthew, Luke, Darlette, LaBar, Derek, Christiansen, Theresa, Howard, Diondra, Biswas, Kousick, Harrington, Cristin, Garcia, Amanda, Bremer, Tammy, Burke, Tara, Koker, Brittany, Davis-Karim, Anne, Pittman, David, Vasudeva, Shikha S., Johnstone, Jaylynn R., Agnetti, Kate, Davis, Ruby, Trautner, Barbara, Hines-Munson, Casey, Van, John, Dillon, Laura, Wang, Yiqun, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Caldwell, Erin, Humerickhouse, Edward, Boone, David, McGraw, William, Looney, David J., Mehta, Sanjay R., Johns, Scott Thompson, St. John, Melissa, Raceles, Jacqueline, Sear, Emily, Funk, Stephen, Cesarini, Rosa, Fang, Michelle, Nicalo, Keith, Drake, Wonder, Jones, Beatrice, Holtman, Teresa, Nguyen, Hien H., Maniar, Archana, Johnson, Eric A., Nguyen, Lam, Tran, Michelle T., Barrett, Thomas W., Johnston, Tera, Huggins, John T., Beiko, Tatsiana Y., Hughes, Heather Y., McManigle, William C., Tanner, Nichole T., Washburn, Ronald G., Ardelt, Magdalena, Tuohy, Patricia A., Mixson, Jennifer L., Hinton, Charles G., Thornley, Nicola, Allen, Heather, Elam, Shannon, Boatman, Barry, Baber, Brittany J., Ryant, Rudell, Roller, Brentin, Nguyen, Chinh, Mikail, Amani Morgan, Research, Marivic Hansen, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Holodniy, Mark, Chary, Aarthi, Lu, Kan, Peters, Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, Lars, Staerke, Nina Breinholt, Yehdego, Yordanos, Sondergaard, Ane, Johansen, Isik S., Pedersen, Andreas Arnholdt, Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Holden, Inge K., Lindvig, Susan O., Helleberg, Marie, Gerstoft, Jan, Kirk, Ole, Jensen, Tomas Ostergaard, Madsen, Birgitte Lindegaard, Pedersen, Thomas Ingemann, Harboe, Zitta Barrella, Roge, Birgit Thorup, Hansen, Thomas Michael, Glesner, Matilde Kanstrup, Lofberg, Sandra Valborg, Nielsen, Ariella Denize, Leicht von Huth, Sebastian, Nielsen, Henrik, Thisted, Rikke Krog, Petersen, Kristine Toft, Juhl, Maria Ruwald, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Clara Ellinor Lindnér, Cecilia Ebba, Wiese, Lothar, Knudsen, Lene Surland, Skrøder Nytofte, Nikolaj Julian, Havmøller, Signe Ravn, Expósito, Maria, Badillo, José, Martínez, Ana, Abad, Elena, Chamorro, Ana, Figuerola, Ariadna, Mateu, Lourdes, España, Sergio, Lucero, Maria Constanza, Santos, José Ramón, Lladós, Gemma, Lopez, Cristina, Carabias, Lydia, Molina-Morant, Daniel, Loste, Cora, Bracke, Carmen, Siles, Adrian, Fernández-Cruz, Eduardo, Di Natale, Marisa, Padure, Sergiu, Gomez, Jimena, Ausin, Cristina, Cervilla, Eva, Balastegui, Héctor, Sainz, Carmen Rodríguez, Lopez, Paco, Carbone, Javier, Escobar, Mariam, Balerdi, Leire, Legarda, Almudena, Roldan, Montserrat, Letona, Laura, Muñoz, José, Camprubí, Daniel, Arribas, Jose R., Sánchez, Rocio Montejano, Díaz-Pollán, Beatriz, Stewart, Stefan Mark, Garcia, Irene, Borobia, Alberto, Mora-Rillo, Marta, Estrada, Vicente, Cabello, Noemi, Nuñez-Orantos, M.J., Sagastagoitia, I., Homen, J.R., Orviz, E., Montalvá, Adrián Sánchez, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Salvador, Fernando, Burgos, Joaquin, Morales-Rull, Jose Luis, Moreno Pena, Anna Maria, Acosta, Cristina, Solé-Felip, Cristina, Horcajada, Juan P., Sendra, Elena, Castañeda, Silvia, López-Montesinos, Inmaculada, Gómez-Junyent, Joan, Gonzáles, Carlota Gudiol, Cuervo, Guilermo, Pujol, Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, and Ko, Emily R
Published: 2024
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6. Multidimensional individualized nutritional therapy for individuals with severe chronic obstructive pulmonary disease: study protocol for a registry-based randomized controlled trial

Author: Hegelund, Maria H., Ritz, Christian, Nielsen, Thyge L., Olsen, Mette F., Søborg, Christian, Braagaard, Lone, Mølgaard, Christian, Krogh-Madsen, Rikke, Lindegaard, Birgitte, and Faurholt-Jepsen, Daniel
Published: 2023
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7. High titers of neutralizing SARS-CoV-2 antibodies six months after symptom onset are associated with increased severity in COVID-19 hospitalized patients

Author: Sejdic, Adin, Frische, Anders, Jørgensen, Charlotte Sværke, Rasmussen, Lasse Dam, Trebbien, Ramona, Dungu, Arnold, Holler, Jon G., Ostrowski, Sisse Rye, Eriksson, Robert, Søborg, Christian, Nielsen, Thyge L., Fischer, Thea K., Lindegaard, Birgitte, Franck, Kristina Træholt, and Harboe, Zitta Barrella
Published: 2023
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8. Changes in acromegaly comorbidities, treatment, and outcome over three decades: a nationwide cohort study

Author: Christian Rosendal, Mai Christiansen Arlien-Søborg, Eigil Husted Nielsen, Marianne Skovsager Andersen, Claus Larsen Feltoft, Marianne Klose, Mikkel Andreassen, Niels Henrik Bruun, Jens Otto Lunde Jørgensen, and Jakob Dal
Subjects: cancer endocrinology, acromegaly, acromegaly and cancer, acromegaly treatment, pituitary adenomas, acromegaly comorbidities, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: ObjectiveTo study the time-dependent changes in disease features of Danish patients with acromegaly, including treatment modalities, biochemical outcome, and comorbidities, with a particular focus on cancer and mortality.MethodsPertinent acromegaly-related variables were collected from 739 patients diagnosed since 1990. Data are presented across three decades (1990–1999, 2000–2009, and 2010–2021) based on the year of diagnosis or treatment initiation.ResultsAdenoma size and insulin-like growth factor I (IGF-I) levels at diagnosis did not differ significantly between study periods. The risk of being diagnosed with diabetes, heart disease, sleep apnea, joint disease, and osteoporosis increased from the 1990s to the later decades, while the mortality risk declined to nearly half. The risk of cancer did not significantly change. Treatment changed toward the use of more medical therapy, and fewer patients underwent repeat surgeries or pituitary irradiation. A statistically significant increase in the proportion of patients achieving IGF-I normalization within 3–5 years was observed over time (69%, 83%, and 88%). The proportion of patients with three or more deficient pituitary hormones decreased significantly over time.ConclusionModern medical treatment regimens of acromegaly as well as increased awareness and improved diagnostics for its comorbidities have led to better disease control, fewer patients with severe hypopituitarism, and declining mortality in the Danish cohort of acromegaly patients. The risk of cancer did not increase over the study period.
Published: 2024
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9. Exclusion of older adults and immunocompromised individuals in influenza, pneumococcal and COVID-19 vaccine trials before and after the COVID-19 pandemic

Author: Bukan, Katrine, Pearce-Slade, Toby, Eiberg, Mads, Tinelli, Marco, Yahav, Dafna, Tuells, Jose, Epaulard, Olivier, Holler, Jon G., Roed, Casper, Søborg, Christian, Jensen, Jens-Ulrik Stæhr, and Harboe, Zitta Barrella
Published: 2023
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10. Differences in mammography screening attendance among non-Western immigrants in Denmark, Finland, Iceland and Norway

Author: Sisse Helle Njor, Sirpa Heinävaara, Hrefna Stefansdóttir, Mari Nygård, Eva María Guðmundsdóttir, Sameer Bhargava, Aku Leivonen, Suzanne Campbell, Bo Søborg, Solveig Hofvind, Tytti Sarkeala, Ilse Vejborg, and Maarit Lamminmäki
Subjects: Mammography, Screening, Participation, Immigrants, Barriers, Screening organization, Medicine
Abstract: Several studies have shown that attendance rates are lower among non-Western immigrants than among natives. As the Nordic countries have quite similar health systems and populations but also differences in the organisation of their organised mammography screening programmes, differences in attendance rates could highlight organisational factors that might increase the attendance rates. Mammography screening is offered free of charge in Denmark and Finland, but not in Iceland and Norway. Contrarily to the other countries, Iceland do not send out pre-booked appointment.The study population included natives and non-Western immigrants aged 50–69 years, who had at least one invitation to the national mammography screening programmes in Denmark (2008–2017), Finland (2001–2017), Iceland (2001–2020) or Norway (2001–2015). Relative risks (RRs) of attendance were estimated and adjusted for age group and calendar period.The study population included 116.033 non-Western immigrants and more than 2 million natives. The attendance rates were significantly lower among non-Western immigrants than among natives, with an adjusted relative risk of 0.81/0.80 in Denmark and Finland, 0.62 in Norway, and 0.40 in Iceland. The lower attendance rates among immigrants in Norway and Iceland did not seem to be due to differences in birth country, immigration age, or educational level, but might be explained by organisational factors.Offering free-of-charge mammography screening in Norway and Iceland and/or including a pre-booked appointment in the invitation letters in Iceland might increase the attendance rate among non-Western immigrants.
Published: 2023
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11. Differences in mammography screening attendance among non-Western immigrants in Denmark, Finland, Iceland and Norway

Author: Njor, Sisse Helle, Heinävaara, Sirpa, Stefansdóttir, Hrefna, Nygård, Mari, Guðmundsdóttir, Eva María, Bhargava, Sameer, Leivonen, Aku, Campbell, Suzanne, Søborg, Bo, Hofvind, Solveig, Sarkeala, Tytti, Vejborg, Ilse, and Lamminmäki, Maarit
Published: 2023
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12. SARS-CoV-2 vaccine-induced antibodies protect against Omicron breakthrough infection

Author: Lundgren, J., Østergaard, L., Benfield, T., Krohn-Dehli, L., Petersen, D.K., Fogh, K., Højmark, E., Iversen, K.K., Bek, P., Klastrup, V., Larsen, F., Rasmussen, S.H., Schleimann, M.H., Schieber, S., Stærke, N.B., Søndergaard, A., Tarp, B., Tousgaard, M., Yehdego, Y., Bodilsen, J., Nielsen, H., Petersen, K.T., Ruwald, M., Thisted, R.K., Caspersen, S.F., Iversen, M., Knudsen, L.S., Meyerhoff, J.L., Sander, L.G., Wiese, L., Abildgaard, C., Holden, I.K., Johansen, N.E., Johansen, I.S., Larsen, L., Lindvig, S.O., Madsen, L.W., Øvrehus, A., Kruse, N.A., Lomholdt, H., Krause, T.G., Valentiner-Branth, P., Søborg, B., Fischer, T.K., Erikstrup, C., Ostrowski, S.R., Tolstrup, M., Søgaard, O.S., Raben, D., Jylling, E., Hougaard, D., Andersen, S.D., Lykkegaard, K., Andreasen, S.R., Baerends, E., Dietz, L.L., Hvidt, A.K., Juhl, A.K., Olesen, R., Andersen, K.K., Bannister, W., Bjernved, C., Elsing, T.W., Esmann, F.V., Ghafari, M.A., Gravholdt, E., Jakobsen, S.F., Jakobsen, M.L., Jensen, C.M., Jensen, T.Ø., Kristensen, D., Kumar, L.R., Matthews, C., Normand, N., Olsson, C., Reekie, J., Traytel, A., Weide, T., Hvas, A.M., Støvring, H., Baerends, Eva A.M., Hvidt, Astrid K., Reekie, Joanne, Søgaard, Ole S., Stærke, Nina B., Raben, Dorthe, Nielsen, Henrik, Petersen, Kristine T., Juhl, Maria R., Johansen, Isik S., Lindvig, Susan O., Madsen, Lone W., Wiese, Lothar, Knudsen, Lene S., Iversen, Mette B., Benfield, Thomas, Iversen, Kasper K., Andersen, Sidsel D., Juhl, Anna K., Dietz, Lisa L., Andreasen, Signe R., Fischer, Thea K., Erikstrup, Christian, Valentiner-Branth, Palle, Lundgren, Jens, Østergaard, Lars, and Tolstrup, Martin
Published: 2023
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13. Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7

Author: Krantz, Mette Falkenberg, Hjorthøj, Carsten, Ellersgaard, Ditte, Hemager, Nicoline, Christiani, Camilla, Spang, Katrine Søborg, Burton, Birgitte Klee, Gregersen, Maja, Søndergaard, Anne, Greve, Aja, Ohland, Jessica, Mortensen, Preben Bo, Plessen, Kerstin Jessica, Bliksted, Vibeke, Jepsen, Jens Richardt Møllegaard, Thorup, Anne A. E., Mors, Ole, and Nordentoft, Merete
Published: 2023
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14. Effects of Social Facilitation and Introduction Methods for Cattle on Virtual Fence Adaptation

Author: Pernille Arent Simonsen, Niels Søborg Husted, Magnus Clausen, Amalie-Maria Spens, Rasmus Majland Dyrholm, Ida Fabricius Thaysen, Magnus Fjord Aaser, Søren Krabbe Staahltoft, Dan Bruhn, Aage Kristian Olsen Alstrup, Christian Sonne, and Cino Pertoldi
Subjects: animals, virtual fencing, Nofence©, Angus cattle, social facilitation, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract: Agricultural industries rely on physical fences to manage livestock. However, these present practical, financial, and ecological challenges, which may be solved using virtual fencing. This study aimed to identify how experienced cattle through social facilitation and the introduction method influence inexperienced cattle. Based on three stocks held in Fanø, Denmark, containing 12, 17 and 13 Angus (Bos taurus), we examined the virtual fence learning in three case studies using one gradual introduction with zero experienced cattle (A) and two different instant introductions with one (B) and ten (C) experienced cattle. Gradual introduction had the virtual fence moved 20 m every other day for eleven days, and in the two instant introductions, the physical fence was removed in one day. Warnings and impulses were recorded during an 11-day learning period and a 26-day post-learning period, using the impulses per warning to quantify if the cattle adapted. Case studies A and B showed a significant reduction in the warnings and impulses, but only A showed a significant reduction in the impulses per warning when comparing the learning period to the post-learning period. Due to the non-standardised experiments, it was not possible to conclude if the number of experienced cattle or the introduction method had an effect on the results.
Published: 2024
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15. SARS-CoV-2 vaccine-induced antibodies protect against Omicron breakthrough infection

Author: Eva A.M. Baerends, Astrid K. Hvidt, Joanne Reekie, Ole S. Søgaard, Nina B. Stærke, Dorthe Raben, Henrik Nielsen, Kristine T. Petersen, Maria R. Juhl, Isik S. Johansen, Susan O. Lindvig, Lone W. Madsen, Lothar Wiese, Lene S. Knudsen, Mette B. Iversen, Thomas Benfield, Kasper K. Iversen, Sidsel D. Andersen, Anna K. Juhl, Lisa L. Dietz, Signe R. Andreasen, Thea K. Fischer, Christian Erikstrup, Palle Valentiner-Branth, Jens Lundgren, Lars Østergaard, Martin Tolstrup, J. Lundgren, L. Østergaard, T. Benfield, L. Krohn-Dehli, D.K. Petersen, K. Fogh, E. Højmark, K.K. Iversen, P. Bek, V. Klastrup, F. Larsen, S.H. Rasmussen, M.H. Schleimann, S. Schieber, N.B. Stærke, A. Søndergaard, B. Tarp, M. Tousgaard, Y. Yehdego, J. Bodilsen, H. Nielsen, K.T. Petersen, M. Ruwald, R.K. Thisted, S.F. Caspersen, M. Iversen, L.S. Knudsen, J.L. Meyerhoff, L.G. Sander, L. Wiese, C. Abildgaard, I.K. Holden, N.E. Johansen, I.S. Johansen, L. Larsen, S.O. Lindvig, L.W. Madsen, A. Øvrehus, N.A. Kruse, H. Lomholdt, T.G. Krause, P. Valentiner-Branth, B. Søborg, T.K. Fischer, C. Erikstrup, S.R. Ostrowski, M. Tolstrup, O.S. Søgaard, D. Raben, E. Jylling, D. Hougaard, S.D. Andersen, K. Lykkegaard, S.R. Andreasen, E. Baerends, L.L. Dietz, A.K. Hvidt, A.K. Juhl, R. Olesen, K.K. Andersen, W. Bannister, C. Bjernved, T.W. Elsing, F.V. Esmann, M.A. Ghafari, E. Gravholdt, S.F. Jakobsen, M.L. Jakobsen, C.M. Jensen, T.Ø. Jensen, D. Kristensen, L.R. Kumar, C. Matthews, N. Normand, C. Olsson, J. Reekie, A. Traytel, T. Weide, A.M. Hvas, and H. Støvring
Subjects: Immunology, Molecular medicine, Immune response, Science
Abstract: Summary: SARS-CoV-2 Omicron quickly spread globally, also in regions with high vaccination coverage, emphasizing the importance of exploring the immunological requirements for protection against Omicron breakthrough infection.The test-negative matched case-control study (N = 964) characterized Omicron breakthrough infections in triple-vaccinated individuals from the ENFORCE cohort. Within 60 days before a PCR test spike-specific IgG levels were significantly lower in cases compared to controls (GMR [95% CI] for BA.2: 0.83 [0.73–0.95], p = 0.006). Multivariable logistic regression showed significant associations between high antibody levels and lower odds of infection (aOR [95% CI] for BA.2 spike-specific IgG: 0.65 [0.48–0.88], p = 0.006 and BA.2 ACE2-blocking antibodies: 0.46 [0.30–0.69], p = 0.0002). A sex-stratified analysis showed more pronounced associations for females than males.High levels of vaccine-induced antibodies provide partial protection against Omicron breakthrough infections. This is important knowledge to further characterize a threshold for protection against new variants and to estimate the necessity and timing of booster vaccination.
Published: 2023
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16. Hair cortisol concentrations and daily life stress in 7-year-old children at familial high-risk of schizophrenia or bipolar disorder. The Danish High Risk and Resilience Study – VIA 7

Author: Brandt, Julie Marie, Hemager, Nicoline, Ellersgaard, Ditte, Gregersen, Maja, Søndergaard, Anne, Ohland, Jessica, Søborg Spang, Katrine, Christiani, Camilla, Burton, Birgitte Klee, Greve, Aja, Hjorthøj, Carsten, Mors, Ole, Plessen, Kerstin Jessica, Møllegaard Jepsen, Jens Richardt, Nordentoft, Merete, and Elgaard Thorup, Anne Amalie
Published: 2023
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17. Multidimensional individualized nutritional therapy for individuals with severe chronic obstructive pulmonary disease: study protocol for a registry-based randomized controlled trial

Author: Maria H. Hegelund, Christian Ritz, Thyge L. Nielsen, Mette F. Olsen, Christian Søborg, Lone Braagaard, Christian Mølgaard, Rikke Krogh-Madsen, Birgitte Lindegaard, and Daniel Faurholt-Jepsen
Subjects: Chronic obstructive pulmonary disease, Quality of life, Nutritional status, Nutritional therapy, Mental health, Body composition, Medicine (General), R5-920
Abstract: Abstract Background Individuals with severe chronic obstructive pulmonary disease (COPD) are often at risk of undernutrition with low health-related quality of life (HRQoL). Undernutrition can worsen COPD and other comorbidities, be an independent predictor of morbidity and functional decline resulting in increased healthcare consumption and increased risk of death. Especially exacerbations and acute infections result in unintentional weight loss. The aim is to investigate the effect of an individualized nutritional intervention among individuals with severe COPD. Methods An open-label randomized controlled trial with two parallel groups. Participants are recruited from the pulmonary outpatient clinic at the Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North Zealand, Denmark, and randomly allocated to either the intervention (intervention + standard of care) or control group (standard of care). The intervention has a duration of 3 months and combines individual nutritional care with adherence support and practical tools. It contains 4 elements including an individual nutritional plan, regular contacts, adherence support, and weight diary. The primary outcome is a difference in HRQoL (EQ-5D-5L) between the intervention and control group 3 months after baseline. Difference in functional capacity (grip strength, 30-s stand chair test, and physical activity), disease-specific quality of life (COPD Assessment Test), anxiety and depression (Hospital Anxiety and Depression Scale), nutritional parameters (energy and protein intake), anthropometry (weight, body mass index, waist, hip, and upper arm circumference), body composition (total fat-free and fat mass and indices), and prognosis (exacerbations, oxygen therapy, hospital contacts, and mortality) 3 months after baseline will be included as secondary outcomes. Data will be collected through home visits at baseline and 1 and 3 months after baseline. Discussion Currently, nutritional care is a neglected area of outpatient care among individuals with severe COPD. If this patient-centered approach can demonstrate a positive impact on HRQoL, mortality, and hospital contacts, it should be recommended as part of end-of-life care for individuals with severe COPD. Trial registration ClinicalTrials.gov NCT04873856 . Registered on May 3, 2021.
Published: 2023
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18. High titers of neutralizing SARS-CoV-2 antibodies six months after symptom onset are associated with increased severity in COVID-19 hospitalized patients

Author: Adin Sejdic, Anders Frische, Charlotte Sværke Jørgensen, Lasse Dam Rasmussen, Ramona Trebbien, Arnold Dungu, Jon G. Holler, Sisse Rye Ostrowski, Robert Eriksson, Christian Søborg, Thyge L. Nielsen, Thea K. Fischer, Birgitte Lindegaard, Kristina Træholt Franck, and Zitta Barrella Harboe
Subjects: COVID-19, Neutralizing antibodies, Viral culturing, Viral load, Disease severity, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Background Viral shedding and neutralizing antibody (NAb) dynamics among patients hospitalized with severe coronavirus disease 2019 (COVID-19) and immune correlates of protection have been key questions throughout the pandemic. We investigated the duration of reverse transcriptase-polymerase chain reaction (RT-PCR) positivity, infectious viral shedding and NAb titers as well as the association between NAb titers and disease severity in hospitalized COVID-19 patients in Denmark 2020–2021. Materials and methods Prospective single-center observational cohort study of 47 hospitalized COVID-19 patients. Oropharyngeal swabs were collected at eight time points during the initial 30 days of inclusion. Serum samples were collected after a median time of 7 (IQR 5 – 10), 37 (IQR 35 – 38), 97 (IQR 95 – 100), and 187 (IQR 185 – 190) days after symptom onset. NAb titers were determined by an in-house live virus microneutralization assay. Viral culturing was performed in Vero E6 cells. Results Patients with high disease severity had higher mean log2 NAb titers at day 37 (1.58, 95% CI [0.34 –2.81]), 97 (2.07, 95% CI [0.53–3.62]) and 187 (2.49, 95% CI [0.20– 4.78]) after symptom onset, compared to patients with low disease severity. Peak viral load (0.072, 95% CI [− 0.627 – 0.728]), expressed as log10 SARS-CoV-2 copies/ml, was not associated with disease severity. Virus cultivation attempts were unsuccessful in almost all (60/61) oropharyngeal samples collected shortly after hospital admission. Conclusions We document an association between high disease severity and high mean NAb titers at days 37, 97 and 187 after symptom onset. However, peak viral load during admission was not associated with disease severity. Trial registration. The study is registered at https://clinicaltrials.gov/ (NCT05274373).
Published: 2023
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19. Concurrent participation in breast, cervical, and colorectal cancer screening programmes in Denmark: A nationwide registry-based study

Author: Njor, Sisse Helle, Søborg, Bo, Tranberg, Mette, and Rebolj, Matejka
Published: 2023
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20. Acromegaly management in the Nordic countries: A Delphi consensus survey

Author: Arlien‐Søborg, Mai C., primary, Dal, Jakob, additional, Heck, Ansgar, additional, Stochholm, Kirstine, additional, Husted, Eigil, additional, Feltoft, Claus Larsen, additional, Rasmussen, Åse Krogh, additional, Feldt‐Rasmussen, Ulla, additional, Andreassen, Mikkel, additional, Klose, Marianne Christina, additional, Nielsen, Torben Leo, additional, Andersen, Marianne Skovsager, additional, Christensen, Louise Lehmann, additional, Krogh, Jesper, additional, Jarlov, Anne, additional, Bollerslev, Jens, additional, Nermoen, Ingrid, additional, Oksnes, Marianne, additional, Dahlqvist, Per, additional, Olsson, Tommy, additional, Berinder, Katarina, additional, Hoybye, Charlotte, additional, Petersson, Maria, additional, Akerman, Anna‐karin, additional, Wahlberg, Jeanette, additional, Ekman, Bertil, additional, Engstrom, Britt Eden, additional, Johannsson, Gudmundur, additional, Ragnarsson, Oskar, additional, Olsson, Daniel, additional, Sigurjónsdóttir, Helga Ágústa, additional, Fougner, Stine Lyngvi, additional, Matikainen, Niina, additional, Vehkavaara, Satu, additional, Metso, Saara, additional, Jaatinen, Pia, additional, Hämäläinen, Päivi, additional, Rintamäki, Reeta, additional, Yliaska, Iina, additional, Immonen, Heidi, additional, Mäkimattila, Sari, additional, Cederberg‐Tamminen, Henna, additional, Viukari, Marianna, additional, Nevalainen, Pasi, additional, Nuutila, Pirjo, additional, Schalin‐Jäntti, Camilla, additional, Burman, Pia, additional, and Jørgensen, Jens Otto Lunde, additional
Published: 2024
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21. Heterogeneity of social cognitive and language functions in children at familial high-risk of severe mental illness; The Danish High Risk and Resilience Study VIA 7

Author: Christiani, Camilla Jerlang, Hemager, Nicoline, Ellersgaard, Ditte, Thorup, Anne A. E., Spang, Katrine Søborg, Burton, Birgitte Klee, Gregersen, Maja, Søndergaard, Anne, Greve, Aja, Gantriis, Ditte Lou, Mors, Ole, Plessen, Kerstin J., Nordentoft, Merete, and Jepsen, Jens Richardt Møllegaard
Published: 2022
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22. Executive functions in 7-year-old children of parents with schizophrenia or bipolar disorder compared with controls: The Danish High Risk and Resilience Study—VIA 7, a population-based cohort study

Author: Spang, Katrine Søborg, Ellersgaard, Ditte, Hemager, Nicoline, Christiani, Camilla Jerlang, Burton, Birgitte Klee, Greve, Aja Neergaard, Gantriis, Ditte, Ohland, Jessica, Pedersen, Marianne Giørtz, Mors, Ole, Nordentoft, Merete, Plessen, Kerstin J., Obel, Carsten, Jepsen, Jens Richardt Møllegaard, and Thorup, Anne A. E.
Published: 2021
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23. Effects of Social Facilitation and Introduction Methods for Cattle on Virtual Fence Adaptation

Author: Simonsen, Pernille Arent, primary, Husted, Niels Søborg, additional, Clausen, Magnus, additional, Spens, Amalie-Maria, additional, Dyrholm, Rasmus Majland, additional, Thaysen, Ida Fabricius, additional, Aaser, Magnus Fjord, additional, Staahltoft, Søren Krabbe, additional, Bruhn, Dan, additional, Alstrup, Aage Kristian Olsen, additional, Sonne, Christian, additional, and Pertoldi, Cino, additional
Published: 2024
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24. Relative vaccine protection, disease severity, and symptoms associated with the SARS-CoV-2 omicron subvariant BA.2.86 and descendant JN.1 in Denmark: a nationwide observational study

Author: Moustsen-Helms, Ida Rask, primary, Bager, Peter, additional, Larsen, Tine Graakjær, additional, Møller, Frederik Trier, additional, Vestergaard, Lasse Skafte, additional, Rasmussen, Morten, additional, Hansen, Christian Holm, additional, Christiansen, Lasse Engbo, additional, Gubbels, Sophie, additional, Trebbien, Ramona, additional, Westergaard, Casper, additional, Escobar-Herrera, Leandro Andrés, additional, Gunalan, Vithiagaran, additional, Ring, Aleksander, additional, Bennedbæk, Marc, additional, Steenhard, Nina, additional, Mørk Hartmann, Esben, additional, Nielsen, Lene, additional, Terp Andersen, Dorte, additional, Thomsen, Marianne Kragh, additional, Marmolin, Ea Sofie, additional, Vognbjerg Sydenham, Thomas, additional, Hoegh, Silje Vermedal, additional, Pinholt, Mette, additional, Møller, Josefine Tange, additional, Vasehus Madsen, Tina, additional, Fuglsang-Damgaard, David, additional, Jokelainen, Pikka, additional, Krause, Tyra Grove, additional, Ullum, Henrik, additional, Søborg, Bolette, additional, and Valentiner-Branth, Palle, additional
Published: 2024
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25. Excess mortality in Europe coincides with peaks of COVID-19, influenza and respiratory syncytial virus (RSV), November 2023 to February 2024

Author: Nørgaard, Sarah K, primary, Nielsen, Jens, additional, Nordholm, Anne Christine, additional, Richter, Lukas, additional, Chalupka, Alena, additional, Sierra, Natalia Bustos, additional, Braeye, Toon, additional, Athanasiadou, Maria, additional, Lytras, Theodore, additional, Denissov, Gleb, additional, Luomala, Oskari, additional, Fouillet, Anne, additional, Pontais, Isabelle, additional, an der Heiden, Matthias, additional, Zacher, Benedikt, additional, Weigel, Alina, additional, Foppa, Ivo, additional, Gkolfinopoulou, Kassiani, additional, Panagoulias, Ioannis, additional, Paldy, Anna, additional, Malnasi, Tibor, additional, Domegan, Lisa, additional, Kelly, Eva, additional, Rotem, Naama, additional, Rakhlin, Oksana, additional, de'Donato, Francesca K, additional, Di Blasi, Chiara, additional, Hoffmann, Patrick, additional, Velez, Telma, additional, England, Kathleen, additional, Calleja, Neville, additional, van Asten, Liselotte, additional, Jongenotter, Femke, additional, Rodrigues, Ana Paula, additional, Silva, Susana, additional, Klepac, Petra, additional, Gomez-Barroso, Diana, additional, Gomez, Inmaculada Leon, additional, Galanis, Ilias, additional, Farah, Ahmed, additional, Weitkunat, Rolf, additional, Fehst, Katarina, additional, Andrews, Nick, additional, Clare, Tom, additional, Bradley, Declan T, additional, O'Doherty, Mark G, additional, William, Naoma, additional, Hamilton, Mark, additional, Søborg, Bolette, additional, Krause, Tyra G, additional, Bundle, Nick, additional, and Vestergaard, Lasse S, additional
Published: 2024
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26. Compensated Hypogonadism Identified in Males with Cluster Headache: A Prospective Case‐Controlled Study

Author: Petersen, Anja S., primary, Kristensen, David M., additional, Westgate, Connar S. J., additional, Folkmann‐Hansen, Thomas, additional, Lund, Nunu, additional, Barloese, Mads, additional, Søborg, Marie‐Louise K., additional, Snoer, Agneta, additional, Johannsen, Trine H., additional, Frederiksen, Hanne, additional, Juul, Anders, additional, and Jensen, Rigmor H., additional
Published: 2024
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27. Effects of Social Facilitation and Introduction Methods of Cattle on Virtual Fence Adaptation

Author: Simonsen, Pernille Arent, primary, Husted, Niels Søborg, additional, Clausen, Magnus, additional, Spens, Amalie-Maria, additional, Dyrholm, Ramus Majland, additional, Thaysen, Ida Fabricius, additional, Aaser, Magnus Fjord, additional, Staahltoft, Søren Krabbe, additional, Bruhn, Dan, additional, Alstrup, Aage Kristian Olsen, additional, Sonne, Christian, additional, and Pertoldi, Cino, additional
Published: 2024
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28. Prevalence of self-reported abdominal symptoms among 50–74-years-old men and women eligible for colorectal cancer screening –a cross-sectional study

Author: Mette Bach Larsen, Heidi Heinsen Bachmann, Bo Søborg, Tinne Laurberg, Katrine J. Emmertsen, Søren Laurberg, and Berit Andersen
Subjects: Abdominal symptoms, Prevalence, Low anterior resection syndrome score (LARS), Patient assessment of constipation-symptoms (PAC-SYM), Mass screening, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Screening is defined as the identification of unrecognized disease in an apparently healthy population. Symptomatic individuals are recommended to contact a physician instead of participating in screening. However, in colorectal cancer (CRC) screening this approach may be problematic as abdominal symptoms are nonspecific. This study aimed at identifying the prevalence of self-reported abdominal symptoms among screening-eligible men and women aged 50–74 years. Methods This cross-sectional survey study included 11,537 individuals aged 50–74 years invited for CRC screening from 9 to 23 September 2019. Descriptive statistics of responders experiencing alarm symptoms of CRC, Low Anterior Resection Syndrome Score (LARS) and the Patient Assessment of Constipation-Symptoms (PAC-SYM) were derived. The association between abdominal symptoms and demographic and socioeconomic variables were estimated by prevalence ratio (PR) using a Poisson regression model with robust variance. Results A total of 5488 respondents were included. The respondents were more likely women, of older age, Danish, cohabiting and had higher education and income level compared to non-respondents. Abdominal pain more than once a week was experienced by 12.0% of the respondents. Of these, 70.8% had been experiencing this symptom for >1 month. Fresh blood in the stool was experienced by 0.7% and of these 82.1% for >1 month. About one third of those experiencing alarm symptoms more than once a week for >1 month had not consulted a doctor. A total of 64.1% of the respondents had no LARS, 21.7% had minor LARS and 14.2% had major LARS. The median PAC-SYM score was 0.33 (Interquartile range (IQR): 0.17;0.75), the median abdominal score was 0.50 (IQR: 0.00;1.00), median rectal score 0.00 (IQR:0.00;0.33) and median stool score 0.40 (IQR: 0.00;0.80). Men and those aged 65–74 reported less symptoms than women and those aged 50–64 years, respectively. Conclusions This study illustrated that abdominal symptoms were frequent among screening-eligible men and women. This should be taken into account when implementing and improving CRC screening strategies. A concerning high number of the respondents experiencing alarm symptoms had not consulted a doctor. This calls for attention to abdominal symptoms in general and how those with abdominal symptoms should participate in CRC screening.
Published: 2021
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29. Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7

Author: Hemager, Nicoline, Jepsen, Jens Richardt Møllegaard, Thorup, Anne, Christiani, Camilla, Ellersgaard, Ditte, Spang, Katrine Søborg, Burton, Birgitte Klee, Gregersen, Maja, Søndergaard, Anne, Greve, Aja Neergaard, Gantriis, Ditte Lou, Mors, Ole, Nordentoft, Merete, and Plessen, Kerstin J.
Published: 2021
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30. Development of visual attention from age 7 to age 12 in children with familial high risk for schizophrenia or bipolar disorder

Author: Ver Loren van Themaat, Anna Hester, Hemager, Nicoline, Korsgaard Johnsen, Line, Klee Burton, Birgitte, Ellersgaard, Ditte, Christiani, Camilla, Brandt, Julie, Gregersen, Maja, Falkenberg Krantz, Mette, Søborg Spang, Katrine, Søndergaard, Anne, Møllegaard Jepsen, Jens Richardt, Elgaard Thorup, Anne Amalie, Siebner, Hartwig Roman, Plessen, Kerstin Jessica, Nordentoft, Merete, and Vangkilde, Signe
Published: 2021
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31. Acromegaly management in the nordic countries : a Delphi consensus survey

Author: Arlien-Søborg, Mai C., Dal, Jakob, Heck, Ansgar, Stochholm, Kirstine, Husted, Eigil, Feltoft, Claus Larsen, Rasmussen, Åse Krogh, Feldt-Rasmussen, Ulla, Andreassen, Mikkel, Klose, Marianne Christina, Nielsen, Torben Leo, Andersen, Marianne Skovsager, Christensen, Louise Lehmann, Krogh, Jesper, Jarlov, Anne, Bollerslev, Jens, Nermoen, Ingrid, Oksnes, Marianne, Dahlqvist, Per, Olsson, Tommy, Berinder, Katarina, Hoybye, Charlotte, Petersson, Maria, Akerman, Anna-karin, Wahlberg, Jeanette, Ekman, Bertil, Engstrom, Britt Eden, Johannsson, Gudmundur, Ragnarsson, Oskar, Olsson, Daniel, Sigurjónsdóttir, Helga Ágústa, Fougner, Stine Lyngvi, Matikainen, Niina, Vehkavaara, Satu, Metso, Saara, Jaatinen, Pia, Hämäläinen, Päivi, Rintamäki, Reeta, Yliaska, Iina, Immonen, Heidi, Mäkimattila, Sari, Cederberg-Tamminen, Henna, Viukari, Marianna, Nevalainen, Pasi, Nuutila, Pirjo, Schalin-Jäntti, Camilla, Burman, Pia, Jørgensen, Jens Otto Lunde, Arlien-Søborg, Mai C., Dal, Jakob, Heck, Ansgar, Stochholm, Kirstine, Husted, Eigil, Feltoft, Claus Larsen, Rasmussen, Åse Krogh, Feldt-Rasmussen, Ulla, Andreassen, Mikkel, Klose, Marianne Christina, Nielsen, Torben Leo, Andersen, Marianne Skovsager, Christensen, Louise Lehmann, Krogh, Jesper, Jarlov, Anne, Bollerslev, Jens, Nermoen, Ingrid, Oksnes, Marianne, Dahlqvist, Per, Olsson, Tommy, Berinder, Katarina, Hoybye, Charlotte, Petersson, Maria, Akerman, Anna-karin, Wahlberg, Jeanette, Ekman, Bertil, Engstrom, Britt Eden, Johannsson, Gudmundur, Ragnarsson, Oskar, Olsson, Daniel, Sigurjónsdóttir, Helga Ágústa, Fougner, Stine Lyngvi, Matikainen, Niina, Vehkavaara, Satu, Metso, Saara, Jaatinen, Pia, Hämäläinen, Päivi, Rintamäki, Reeta, Yliaska, Iina, Immonen, Heidi, Mäkimattila, Sari, Cederberg-Tamminen, Henna, Viukari, Marianna, Nevalainen, Pasi, Nuutila, Pirjo, Schalin-Jäntti, Camilla, Burman, Pia, and Jørgensen, Jens Otto Lunde
Abstract: Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries. Methods: A Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1−7). Consensus was defined as ≥80% of panelists rating their agreement as ≥5 or ≤3 on the Likert-type scale. Results: Consensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists. Conclusion: This consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
Published: 2024
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32. Compensated Hypogonadism Identified in Males with Cluster Headache:A Prospective Case-Controlled Study

Author: Petersen, Anja S., Kristensen, David M., Westgate, Connar S. J., Folkmann-Hansen, Thomas, Lund, Nunu, Barloese, Mads, Søborg, Marie Louise K., Snoer, Agneta, Johannsen, Trine H., Frederiksen, Hanne, Juul, Anders, Jensen, Rigmor H., Petersen, Anja S., Kristensen, David M., Westgate, Connar S. J., Folkmann-Hansen, Thomas, Lund, Nunu, Barloese, Mads, Søborg, Marie Louise K., Snoer, Agneta, Johannsen, Trine H., Frederiksen, Hanne, Juul, Anders, and Jensen, Rigmor H.
Abstract: Objective Androgens have been hypothesized to be involved in the pathophysiology of cluster headache due to the male predominance, but whether androgens are altered in patients with cluster headache remains unclear. Methods We performed a prospective, case-controlled study in adult males with cluster headache. Sera were measured for hormones including testosterone, luteinizing hormone (LH), and sex hormone-binding globulin in 60 participants with episodic cluster headache (during a bout and in remission), 60 participants with chronic cluster headache, and 60 age- and sex-matched healthy controls. Free testosterone (fT) was calculated according to the Vermeulen equation. Shared genetic risk variants were assessed between cluster headache and testosterone concentrations. Results The mean fT/LH ratio was reduced by 35% (95% confidence interval [CI]: 21%–47%, p < 0.0001) in patients with chronic cluster headache and by 24% (95% CI: 9%–37%, p = 0.004) in patients with episodic cluster headache compared to controls after adjusting for age, sleep duration, and use of acute medication. Androgen concentrations did not differ between bouts and remissions. Furthermore, a shared genetic risk allele, rs112572874 (located in the intron of the microtubule associated protein tau (MAPT) gene on chromosome 17), between fT and cluster headache was identified. Interpretation Our results demonstrate that the male endocrine system is altered in patients with cluster headache to a state of compensated hypogonadism, and this is not an epiphenomenon associated with sleep or the use of acute medication. Together with the identified shared genetic risk allele, this may suggest a pathophysiological link between cluster headache and fT. ANN NEUROL 2024, Objective: Androgens have been hypothesized to be involved in the pathophysiology of cluster headache due to the male predominance, but whether androgens are altered in patients with cluster headache remains unclear. Methods: We performed a prospective, case-controlled study in adult males with cluster headache. Sera were measured for hormones including testosterone, luteinizing hormone (LH), and sex hormone-binding globulin in 60 participants with episodic cluster headache (during a bout and in remission), 60 participants with chronic cluster headache, and 60 age- and sex-matched healthy controls. Free testosterone (fT) was calculated according to the Vermeulen equation. Shared genetic risk variants were assessed between cluster headache and testosterone concentrations. Results: The mean fT/LH ratio was reduced by 35% (95% confidence interval [CI]: 21%–47%, p < 0.0001) in patients with chronic cluster headache and by 24% (95% CI: 9%–37%, p = 0.004) in patients with episodic cluster headache compared to controls after adjusting for age, sleep duration, and use of acute medication. Androgen concentrations did not differ between bouts and remissions. Furthermore, a shared genetic risk allele, rs112572874 (located in the intron of the microtubule associated protein tau (MAPT) gene on chromosome 17), between fT and cluster headache was identified. Interpretation: Our results demonstrate that the male endocrine system is altered in patients with cluster headache to a state of compensated hypogonadism, and this is not an epiphenomenon associated with sleep or the use of acute medication. Together with the identified shared genetic risk allele, this may suggest a pathophysiological link between cluster headache and fT. ANN NEUROL 2024.
Published: 2024

33. Biomarkers in cluster headache:A systematic review

Author: Søborg, Marie Louise K., Jensen, Rigmor H., Barloese, Mads, Petersen, Anja S., Søborg, Marie Louise K., Jensen, Rigmor H., Barloese, Mads, and Petersen, Anja S.
Abstract: Objective To systematically investigate previously examined biomarkers in blood, urine, cerebrospinal fluid, tear fluid, and saliva of patients with cluster headache. Background Cluster headache is a condition with extensive clinical challenges in terms of diagnosis and treatment. Identification of a biomarker with diagnostic implications or as a potential treatment target is highly warranted. Methods We conducted a systematic review including peer reviewed full text of studies that measured biochemical compounds in either blood, urine, cerebrospinal fluid, tear fluid, or saliva of patients with cluster headache diagnosed after the implementation of the International Classification of Headache Disorders (1988) written in English, Danish, Swedish, or Norwegian. Inclusion required a minimum of five participants. The search was conducted in PubMed and EMBASE, in September 2022, and extracted data were screened by two authors. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for reporting systematic reviews were followed. The Newcastle–Ottawa Scale was used to assess the risk of bias in case–controlled studies. Results We included 40 studies involving 832 patients with cluster headache and 872 controls, evaluating 80 potential biomarkers. The risk of bias for case–controlled studies was a median of 6 (range: 3–8) and 20 studies out of 40 (50%) were of fair or good quality. Most studies were identified within three groups: hypothalamic-regulated hormones, inflammatory markers, and neuropeptides. Among the hypothalamic hormones, cortisol was the most frequently investigated (N = 7) and was elevated in cluster headache in most of the studies. The most frequently examined inflammatory marker was interleukin 1 (N = 3), but findings were divergent. Calcitonin gene–related peptide was the most investigated neuropeptide (N = 9) and all studies found increased levels during attacks. Conclusion B, Objective: To systematically investigate previously examined biomarkers in blood, urine, cerebrospinal fluid, tear fluid, and saliva of patients with cluster headache. Background: Cluster headache is a condition with extensive clinical challenges in terms of diagnosis and treatment. Identification of a biomarker with diagnostic implications or as a potential treatment target is highly warranted. Methods: We conducted a systematic review including peer reviewed full text of studies that measured biochemical compounds in either blood, urine, cerebrospinal fluid, tear fluid, or saliva of patients with cluster headache diagnosed after the implementation of the International Classification of Headache Disorders (1988) written in English, Danish, Swedish, or Norwegian. Inclusion required a minimum of five participants. The search was conducted in PubMed and EMBASE, in September 2022, and extracted data were screened by two authors. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for reporting systematic reviews were followed. The Newcastle–Ottawa Scale was used to assess the risk of bias in case–controlled studies. Results: We included 40 studies involving 832 patients with cluster headache and 872 controls, evaluating 80 potential biomarkers. The risk of bias for case–controlled studies was a median of 6 (range: 3–8) and 20 studies out of 40 (50%) were of fair or good quality. Most studies were identified within three groups: hypothalamic-regulated hormones, inflammatory markers, and neuropeptides. Among the hypothalamic hormones, cortisol was the most frequently investigated (N = 7) and was elevated in cluster headache in most of the studies. The most frequently examined inflammatory marker was interleukin 1 (N = 3), but findings were divergent. Calcitonin gene–related peptide was the most investigated neuropeptide (N = 9) and all studies found increased levels during attacks. Conclusion: Biomarker findings have been inconsistent and wid
Published: 2024

34. The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11:the Danish high risk and resilience study

Author: Andreassen, Anna Krogh, Lambek, Rikke, Greve, Aja, Hemager, Nicoline, Knudsen, Christina Bruun, Veddum, Lotte, Birk, Merete, Søndergaard, Anne, Brandt, Julie Marie, Gregersen, Maja, Falkenberg-Krantz, Mette, Spang, Katrine Søborg, Ohland, Jessica, Burton, Birgitte Klee, Jepsen, Jens Richardt Møllegaard, Thorup, Anne Amalie Elgaard, Nordentoft, Merete, Mors, Ole, Bliksted, Vibeke Fuglsang, Andreassen, Anna Krogh, Lambek, Rikke, Greve, Aja, Hemager, Nicoline, Knudsen, Christina Bruun, Veddum, Lotte, Birk, Merete, Søndergaard, Anne, Brandt, Julie Marie, Gregersen, Maja, Falkenberg-Krantz, Mette, Spang, Katrine Søborg, Ohland, Jessica, Burton, Birgitte Klee, Jepsen, Jens Richardt Møllegaard, Thorup, Anne Amalie Elgaard, Nordentoft, Merete, Mors, Ole, and Bliksted, Vibeke Fuglsang
Abstract: Executive functions (EF) deficits are well documented in children at familial high risk of schizophrenia (FHR-SZ), and to a lesser degree in children at familial high risk of bipolar disorder (FHR-BP). The aim of this study was to assess EF development in preadolescent children at FHR-SZ, FHR-BP and population-based controls (PBC) using a multi-informant rating scale. A total of 519 children (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 199) participated at age 7, at age 11 or at both time points. Caregivers and teachers completed the Behavior Rating Inventory of Executive Functions (BRIEF). The developmental pattern from age 7 to age 11, did not differ between groups. At age 11, caregivers and teachers rated children at FHR-SZ as having widespread EF deficits. A higher proportion of children at FHR-SZ had clinically significant scores on the General executive composite (GEC) and all BRIEF indices compared to PBC. According to the caregivers, children at FHR-BP had significantly more EF deficits than PBC on 9 out of 13 BRIEF scales, whereas according to teachers, they only had significantly more deficits on one subdomain (Initiate). Likewise, caregivers rated a significantly higher proportion of children at FHR-BP above the clinical cut-off on the GEC and Metacognition index, compared to PBC, whereas there were no significant differences according to teachers. This study highlights the relevance of including multi-informant rating scales in the assessment of EF in children at FHR-SZ and FHR-BP. The results imply a need to identify children at high risk who would benefit from targeted intervention., Executive functions (EF) deficits are well documented in children at familial high risk of schizophrenia (FHR-SZ), and to a lesser degree in children at familial high risk of bipolar disorder (FHR-BP). The aim of this study was to assess EF development in preadolescent children at FHR-SZ, FHR-BP and population-based controls (PBC) using a multi-informant rating scale. A total of 519 children (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 199) participated at age 7, at age 11 or at both time points. Caregivers and teachers completed the Behavior Rating Inventory of Executive Functions (BRIEF). The developmental pattern from age 7 to age 11, did not differ between groups. At age 11, caregivers and teachers rated children at FHR-SZ as having widespread EF deficits. A higher proportion of children at FHR-SZ had clinically significant scores on the General executive composite (GEC) and all BRIEF indices compared to PBC. According to the caregivers, children at FHR-BP had significantly more EF deficits than PBC on 9 out of 13 BRIEF scales, whereas according to teachers, they only had significantly more deficits on one subdomain (Initiate). Likewise, caregivers rated a significantly higher proportion of children at FHR-BP above the clinical cut-off on the GEC and Metacognition index, compared to PBC, whereas there were no significant differences according to teachers. This study highlights the relevance of including multi-informant rating scales in the assessment of EF in children at FHR-SZ and FHR-BP. The results imply a need to identify children at high risk who would benefit from targeted intervention.
Published: 2024

35. Novel genetically glycoengineered human dendritic cell model reveals regulatory roles of α2,6-linked sialic acids in DC activation of CD4+ T cells and response to TNFα.

Author: Tian, Weihua, Blomberg, Anne Louise, Steinberg, Kaylin Elisabeth, Henriksen, Betina Lyngfeldt, Jørgensen, Josefine Søborg, Skovgaard, Kerstin, Skovbakke, Sarah Line, and Goletz, Steffen
Subjects: T cells, DENDRITIC cells, SIALIC acids, HUMAN biology, GLYCOCALYX, IMMUNOREGULATION, T cell receptors, GLYCAN structure
Abstract: Dendritic cells (DCs) are central for the initiation and regulation of appropriate immune responses. While several studies suggest important regulatory roles of sialoglycans in DC biology, our understanding is still inadequate primarily due to a lack of appropriate models. Previous approaches based on enzymatic- or metabolic-glycoengineering and primary cell isolation from genetically modified mice have limitations related to specificity, stability, and species differences. This study addresses these challenges by introducing a workflow to genetically glycoengineer the human DC precursor cell line MUTZ-3, described to differentiate and maturate into fully functional dendritic cells, using CRISPR-Cas9, thereby providing and validating the first isogenic cell model for investigating glycan alteration on human DC differentiation, maturation, and activity. By knocking out (KO) the ST6GAL1 gene, we generated isogenic cells devoid of ST6GAL1-mediated α(2,6)-linked sialylation, allowing for a comprehensive investigation into its impact on DC function. Glycan profiling using lectin binding assay and functional studies revealed that ST6GAL1 KO increased the expression of important antigen presenting and co-stimulatory surface receptors and a specifically increased activation of allogenic human CD4 + T cells. Additionally, ST6GAL1 KO induces significant changes in surface marker expression and cytokine response to TNFα-induced maturation, and it affects migration and the endocytic capacity. These results indicate that genetic glycoengineering of the isogenic MUTZ-3 cellular model offers a valuable tool to study how specific glycan structures influence human DC biology, contributing to our understanding of glycoimmunology. [ABSTRACT FROM AUTHOR]
Published: 2024
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36. Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta.

Author: Rezahosseini, Omid, Roed, Casper, Sejdic, Adin, Eiberg, Mads Frederik, Nielsen, Lene, Boel, Jonas, Johannesen, Caroline Klint, van Wijhe, Maarten, Franck, Kristina Træholt, Ostrowski, Sisse Rye, Lindegaard, Birgitte, Fischer, Thea K., Knudsen, Troels Bygum, Holler, Jon Gitz, Harboe, Zitta Barrella, Lindgaard‐Jensen, Betina, Søborg, Christian, Nielsen, Thyge Lynghøj, Bernhard, Peter Haahr, and Pedersen, Emilie Marie Juelstorp
Subjects: SARS-CoV-2, SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, VIRUS diseases, INTENSIVE care units
Abstract: Background: Respiratory viral infections have significant global health impacts. We compared 30‐day intensive care unit (ICU) admission and all‐cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Delta and Omicron variants versus influenza A and B (A/B). Methods: Data from two retrospective inpatient cohorts in Copenhagen were analyzed. Cohorts included hospitalized influenza A/B patients (2017–2018) and SARS‐CoV‐2 Delta/Omicron patients (2021–2022), aged ≥18 years, admitted within 14 days of a positive real‐time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen–Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality. Results: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p <.001) and 1.5 (p =.34) for Delta and Omicron versus influenza B, and 1.5 (p =.36) and 0.71 (p =.48) versus influenza A. For mortality, aHRs were 3.8 (p <.001) and 3.4 (p <.001) for Delta and Omicron versus influenza B, and 2.1 (p =.04) and 1.9 (p =.11) versus influenza A. Conclusion: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients. [ABSTRACT FROM AUTHOR]
Published: 2024
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37. Grain displacement during backwash of drinking water filters

Author: Loren Ramsay, Feng Du, Majbritt Lund, Haiyan He, and Ditte A. Søborg
Subjects: backwash, biofiltration, drinking water, grain displacement, rapid sand filtration, Water supply for domestic and industrial purposes, TD201-500, River, lake, and water-supply engineering (General), TC401-506
Abstract: Backwashing rapid sand filters causes inadvertent displacement of filter media grains from their previous depths. This displacement can affect the hydraulic function of filters by mixing or segregating media grains, and the function of biofilters through displacement of active biomass and coatings from proper depths. This study quantifies grain displacement in a pilot-scale filter using tracer grains of colored sand, glass beads, anthracite and garnet to determine the effect of grain size, density and shape on grain displacement. Statistical moments are used to describe the depth distributions resulting from displacement during backwashing. Results show that significant grain displacement occurs during backwash consisting of air scour, air-and-water wash and sub-fluidization water-only wash. Here, displacement is largely independent of grain size, density and shape. When fluidization backwash is used, greater displacement and more dependence on grain characteristics is seen. A variety of grain movement phenomena can be observed during the backwashing steps, indicating that grain movement and therefore the resulting displacement is highly inhomogeneous in four dimensions. These results have direct practical implications for the design of rapid sand filters and the optimization of backwashing procedures, while suggesting that the current widespread backwashing practice used in the case study country (Denmark) should be abandoned.
Published: 2021
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38. First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study

Author: Jon Gitz Holler, Robert Eriksson, Tomas Østergaard Jensen, Maarten van Wijhe, Thea Kølsen Fischer, Ole Schmeltz Søgaard, Simone Bastrup Israelsen, Rajesh Mohey, Thilde Fabricius, Frederik Jøhnk, Lothar Wiese, Stine Johnsen, Christian Søborg, Henrik Nielsen, Ole Kirk, Birgitte Lindegaard Madsen, and Zitta Barrella Harboe
Subjects: SARS-CoV-2, COVID-19, Prognostic factors, Mortality, Nationwide, Intensive care unit, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity and laboratory determinants of death and of ICU admission were explored in all Danish hospitalised patients. Methods National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis. Results Among 2431 hospitalised patients with COVID-19 between February 27 and July 8 (median age 69 years [IQR 53–80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p
Published: 2021
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39. The Strengths and Difficulties Questionnaire Is of Clinical Significance Regarding Emotional and Behavioral Problems in 7-Year-Old Children With Familial Risk of Schizophrenia or Bipolar Disorder and Population-Based Controls the Danish High Risk and Resilience Study–VIA 7; A Population-Based Cohort Study

Author: Katrine Søborg Spang, Anne A. E. Thorup, Ditte Ellersgaard, Nicoline Hemager, Camilla Christiani, Birgitte Klee Burton, Ditte Gantriis, Aja Greve, Maja Gregersen, Ole Mors, Merete Nordentoft, Jens Richardt Møllegaard Jepsen, Carsten Obel, and Kerstin J. Plessen
Subjects: SDQ, high risk, bipolar, schizophrenia, behavior, psychopathology, Psychiatry, RC435-571
Abstract: BackgroundChildren born to parents with severe mental illness are at increased risk of mental and behavioral difficulties during childhood. We aimed to investigate the occurrence of clinically significant behavioral difficulties in 7-year-old children of parents diagnosed with schizophrenia or bipolar disorder as well as in control children by using the Strengths and Difficulties Questionnaire (SDQ). Further, we aimed to determine if the SDQ could function as a screening instrument for clinically relevant behavioral problems of children at high risk of these severe mental illnesses.MethodsBy means of the Danish National Registers, we established a cohort of 522 7-year old children stratified by familial high risk for schizophrenia spectrum disorder (N = 202), bipolar disorder (N =120), and controls (N = 200). The child's primary caregiver completed the SDQ parent version and the Child Behavior Checklist (CBCL) while the schoolteacher completed the SDQ teacher version and the CBCL teacher equivalent; the Teachers Report Form (TRF). Finally, global functioning was assessed with the Children's Global Assessment Scale (CGAS).ResultsChildren with familial high risk of schizophrenia spectrum disorder or bipolar disorder have a significantly increased risk (OR = 3.8 and 2.3) of suffering clinically significant behavioral difficulties at age 7-years according to SDQ parent ratings. The SDQ discriminates with moderate to high sensitivity and high specificity between familial high-risk children with and without a psychiatric diagnosis and has overall compelling discriminatory abilities in line with the more time consuming CBCL/TRF.Conclusions Familial high-risk children have more behavioral difficulties and more frequently at a level indicative of mental illness compared to control children as measured by the SDQ. The SDQ works well as a screening instrument for clinically relevant behavioral problems in high-risk children.
Published: 2022
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40. Odor identification in 7-year-old children at familial high risk of schizophrenia or bipolar disorder - the Danish high risk and resilience study VIA 7

Author: Ver Loren van Themaat, Anna Hester, Uddin, Md Jamal, Christiani, Camilla Jerlang, Hemager, Nicoline, Ellersgaard, Ditte, Klee Burton, Birgitte, Spang, Katrine Søborg, Greve, Aja, Gantriis, Ditte, Mors, Ole, Elgaard Thorup, Anne Amalie, Plessen, Kerstin Jessica, Nordentoft, Merete, and Møllegaard Jepsen, Jens Richardt
Published: 2020
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41. Trends in underlying causes of death in allogeneic hematopoietic cell transplant recipients over the last decade

Author: Søborg, Andreas, primary, Reekie, Joanne, additional, Sengeløv, Henrik, additional, Da Cunha‐Bang, Caspar, additional, Lund, Thomas Kromann, additional, Ekenberg, Christina, additional, Lodding, Isabelle Paula, additional, Moestrup, Kasper Sommerlund, additional, Lundgren, Louise, additional, Lundgren, Jens D., additional, and Wareham, Neval Ete, additional
Published: 2024
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42. Short-term effectiveness of the XBB.1.5 updated COVID-19 vaccine against hospitalisation in Denmark: a national cohort study

Author: Hansen, Christian Holm, primary, Moustsen-Helms, Ida Rask, additional, Rasmussen, Morten, additional, Søborg, Bolette, additional, Ullum, Henrik, additional, and Valentiner-Branth, Palle, additional
Published: 2024
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43. Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020: Using the CLASS method for determining specific causes of death

Author: Andreas Søborg, Joanne Reekie, Allan Rasmussen, Caspar Da Cunha-Bang, Finn Gustafsson, Kasper Rossing, Michael Perch, Paul Suno Krohn, Søren Schwartz Sørensen, Thomas Kromann Lund, Vibeke Rømming Sørensen, Christina Ekenberg, Louise Lundgren, Isabelle Paula Lodding, Kasper Sommerlund Moestrup, Jens Lundgren, and Neval Ete Wareham
Subjects: Medicine, Science
Abstract: Monitoring specific underlying causes of death in solid organ transplant (SOT) recipients is important in order to identify emerging trends and health challenges. This retrospective cohort study includes all SOT recipients transplanted at Rigshospitalet between January 1st, 2010 and December 31st, 2019. The underlying cause of death was determined using the newly developed Classification of Death Causes after Transplantation (CLASS) method. Cox regression analyses assessed risk factors for all-cause and cause-specific mortality. Of the 1774 SOT recipients included, 299 patients died during a total of 7511 person-years of follow-up (PYFU) with cancer (N = 57, 19%), graft rejection (N = 55, 18%) and infections (N = 52, 17%) being the most frequent causes of death. We observed a lower risk of all-cause death with increasing transplant calendar year (HR 0.91, 95% CI 0.86–0.96 per 1-year increase), alongside death from graft rejection (HR 0.84 per year, 95% CI 0.74–0.95) and death from infections (HR 0.86 per year, 95% CI 0.77–0.97). Further, there was a trend towards lower cumulative incidence of death from cardiovascular disease, graft failure and cancer in more recent years, while death from other organ specific and non-organ specific causes did not decrease. All-cause mortality among SOT recipients has decreased over the past decade, mainly due to a decrease in graft rejection- and infection-related deaths. Conversely, deaths from a broad range of other causes have remained unchanged, suggesting that cause of death among SOT recipients is increasingly diverse and warrants a multidisciplinary effort and attention in the future.
Published: 2022

44. Reversible insulin resistance in muscle and fat unrelated to the metabolic syndrome in patients with acromegaly

Author: Mai C. Arlien-Søborg, Jakob Dal, Michael Alle Madsen, Morten Lyng Høgild, Astrid Johannesson Hjelholt, Steen B. Pedersen, Niels Møller, Niels Jessen, and Jens O.L. Jørgensen
Subjects: Growth hormone, Acromegaly, Lipolysis, Insulin resistance, Insulin signalling, Medicine, Medicine (General), R5-920
Abstract: Summary: Background: Patients with active acromegaly exhibit insulin resistance despite a lean phenotype whereas controlled disease improves insulin sensitivity and increases fat mass. The mechanisms underlying this paradox remain elusive, but growth hormone (GH)-induced lipolysis plays a central role. The aim of the study was to investigative the molecular mechanisms of insulin resistance dissociated from obesity in patients with acromegaly. Methods: In a prospective study, twenty-one patients with newly diagnosed acromegaly were studied at diagnosis and after disease control obtained by either surgery alone (n=10) or somatostatin analogue (SA) treatment (n=11) with assessment of body composition (DXA scan), whole body and tissue-specific insulin sensitivity and GH and insulin signalling in adipose tissue and skeletal muscle. Findings: Disease control of acromegaly significantly reduced lean body mass (p
Published: 2022
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45. First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study

Author: Holler, Jon Gitz, Eriksson, Robert, Jensen, Tomas Østergaard, van Wijhe, Maarten, Fischer, Thea Kølsen, Søgaard, Ole Schmeltz, Israelsen, Simone Bastrup, Mohey, Rajesh, Fabricius, Thilde, Jøhnk, Frederik, Wiese, Lothar, Johnsen, Stine, Søborg, Christian, Nielsen, Henrik, Kirk, Ole, Madsen, Birgitte Lindegaard, and Harboe, Zitta Barrella
Published: 2021
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46. Prevalence of self-reported abdominal symptoms among 50–74-years-old men and women eligible for colorectal cancer screening –a cross-sectional study

Author: Larsen, Mette Bach, Bachmann, Heidi Heinsen, Søborg, Bo, Laurberg, Tinne, Emmertsen, Katrine J., Laurberg, Søren, and Andersen, Berit
Published: 2021
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47. Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial

Author: Hjelholt, Astrid Johannesson, Lee, Kevin Y., Arlien-Søborg, Mai Christiansen, Pedersen, Steen Bønløkke, Kopchick, John J., Puri, Vishwajeet, Jessen, Niels, and Jørgensen, Jens Otto L.
Published: 2019
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48. Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7

Author: Hemager, Nicoline, Vangkilde, Signe, Thorup, Anne, Christiani, Camilla, Ellersgaard, Ditte, Spang, Katrine Søborg, Burton, Birgitte Klee, Greve, Aja Neergaard, Gantriis, Ditte Lou, Mors, Ole, Jepsen, Jens Richardt Møllegaard, Nordentoft, Merete, and Plessen, Kerstin Jessica
Published: 2019
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49. Changes in acromegaly comorbidities, treatment, and outcome over three decades: a nationwide cohort study.

Author: Rosendal, Christian, Arlien-Søborg, Mai Christiansen, Nielsen, Eigil Husted, Andersen, Marianne Skovsager, Feltoft, Claus Larsen, Klose, Marianne, Andreassen, Mikkel, Bruun, Niels Henrik, Jørgensen, Jens Otto Lunde, and Dal, Jakob
Subjects: ACROMEGALY, SOMATOMEDIN C, COMORBIDITY, COHORT analysis, THERAPEUTICS, DANES, LUTEINIZING hormone releasing hormone
Abstract: Objective: To study the time-dependent changes in disease features of Danish patients with acromegaly, including treatment modalities, biochemical outcome, and comorbidities, with a particular focus on cancer and mortality. Methods: Pertinent acromegaly-related variables were collected from 739 patients diagnosed since 1990. Data are presented across three decades (1990-1999, 2000-2009, and 2010-2021) based on the year of diagnosis or treatment initiation. Results: Adenoma size and insulin-like growth factor I (IGF-I) levels at diagnosis did not differ significantly between study periods. The risk of being diagnosed with diabetes, heart disease, sleep apnea, joint disease, and osteoporosis increased from the 1990s to the later decades, while the mortality risk declined to nearly half. The risk of cancer did not significantly change. Treatment changed toward the use of more medical therapy, and fewer patients underwent repeat surgeries or pituitary irradiation. A statistically significant increase in the proportion of patients achieving IGF-I normalization within 3-5 years was observed over time (69%, 83%, and 88%). The proportion of patients with three or more deficient pituitary hormones decreased significantly over time. Conclusion: Modern medical treatment regimens of acromegaly as well as increased awareness and improved diagnostics for its comorbidities have led to better disease control, fewer patients with severe hypopituitarism, and declining mortality in the Danish cohort of acromegaly patients. The risk of cancer did not increase over the study period. [ABSTRACT FROM AUTHOR]
Published: 2024
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50. Pertussis epidemic in Denmark, August 2023 to February 2024.

Author: Nordholm, Anne Christine, Emborg, Hanne-Dorthe, Nørgaard, Sarah Kristine, Nygaard, Ulrikka, Ronayne, Aoife, Nielsen, Lise Birk, Søborg, Bolette, Andersen, Peter H., and Dalby, Tine
Published: 2024
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