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3. Erratum to “Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue” [Eur J Surg Oncol 49 (5) (May 2023) 974–982]

Author

Ubels, Sander, primary, Matthée, Eric, additional, Verstegen, Moniek, additional, Klarenbeek, Bastiaan, additional, Bouwense, Stefan, additional, van Berge Henegouwen, Mark I., additional, Daams, Freek, additional, Dekker, Jan Willem T., additional, van Det, Marc J., additional, van Esser, Stijn, additional, Griffiths, Ewen A., additional, Haveman, Jan Willem, additional, Nieuwenhuijzen, Grard, additional, Siersema, Peter D., additional, Wijnhoven, Bas, additional, Hannink, Gerjon, additional, van Workum, Frans, additional, Rosman, Camiel, additional, Heisterkamp, Joos, additional, Polat, Fatih, additional, Schouten, Jeroen, additional, Singh, Pritam, additional, Slootmans, Cettela A.M., additional, Ultee, Gijs, additional, Gisbertz, Suzanne S., additional, Eshuis, Wietse J., additional, Kalff, Marianne C., additional, Feenstra, Minke L., additional, van der Peet, Donald L., additional, Stam, Wessel T., additional, Van Etten, Boudewijn, additional, Poelmann, Floris, additional, Vuurberg, Nienke, additional, Willem van den Berg, Jan, additional, Martijnse, Ingrid S., additional, Matthijsen, Robert M., additional, Luyer, Misha, additional, Curvers, Wout, additional, Nieuwenhuijzen, Tom, additional, Taselaar, Annick E., additional, Kouwenhoven, Ewout A., additional, Lubbers, Merel, additional, Sosef, Meindert, additional, Lecot, Frederik, additional, Geraedts, Tessa C.M., additional, van den Wildenberg, Frits, additional, Kelder, Wendy, additional, Baas, Peter C., additional, de Haas, Job W.A., additional, Hartgrink, Henk H., additional, Bahadoer, Renu R., additional, van Sandick, Johanna W., additional, Hartemink, Koen J., additional, Veenhof, Xander, additional, Stockmann, Hein, additional, Gorgec, Burak, additional, Weeder, Pepijn, additional, Wiezer, Marinus J., additional, Genders, Charlotte M.S., additional, Belt, Eric, additional, Blomberg, Bjorn, additional, van Duijvendijk, Peter, additional, Claassen, Linda, additional, Reetz, David, additional, Steenvoorde, Pascal, additional, Mastboom, Walter, additional, Klein Ganseij, Henk Jan, additional, van Dalsen, Annette D., additional, Joldersma, Annalie, additional, Zwakman, Marije, additional, Groenendijk, Richard P.R., additional, Montazeri, Mahsa, additional, Mercer, Stuart, additional, Knight, Benjamin, additional, van Boxel, Gijs, additional, McGregor, Richard J., additional, Skipworth, Richard J.E., additional, Frattini, Cristina, additional, Bradley, Alice, additional, Nilsson, Magnus, additional, Hayami, Masaru, additional, Huang, Biying, additional, Bundred, James, additional, Evans, Richard, additional, Grimminger, Peter P., additional, van der Sluis, Pieter C., additional, Eren, Uzun, additional, Saunders, John, additional, Theophilidou, Elena, additional, Khanzada, Zubair, additional, Elliott, Jessie A., additional, Ponten, Jeroen, additional, King, Sinead, additional, Reynolds, John V., additional, Sgromo, Bruno, additional, Akbari, Khalid, additional, Shalaby, Samar, additional, Gutschow, Christian A., additional, Schmidt, Henner, additional, Vetter, Diana, additional, Moorthy, Krishna, additional, Ibrahim, Mohamed A.H., additional, Christodoulidis, Grigorious, additional, Räsänen, Jari V., additional, Kauppi, Juha, additional, Söderström, Henna, additional, Koshy, Renol, additional, Manatakis, Dimitrios K., additional, Korkolis, Dimitrios P., additional, Balalis, Dimitrios, additional, Rompu, Aliki, additional, Alkhaffaf, Bilal, additional, Alasmar, Mohamed, additional, Arebi, Moaad, additional, Piessen, Guillaume, additional, Nuytens, Frederiek, additional, Degisors, Sebastien, additional, Ahmed, Ahmed, additional, Boddy, Alex, additional, Gandhi, Suraj, additional, Fashina, Oluwatomini, additional, Van Daele, Elke, additional, Pattyn, Piet, additional, Robb, William B., additional, Arumugasamy, Mayilone, additional, Al Azzawi, Mohammed, additional, Whooley, Jack, additional, Colak, Elif, additional, Aybar, Engin, additional, Sari, Ahmet C., additional, Uyanik, Mustafa S., additional, Ciftci, Ahmet B., additional, Sayyed, Raza, additional, Ayub, Bushra, additional, Murtaza, Ghulam, additional, Saeed, Aniqa, additional, Ramesh, Priyanka, additional, Charalabopoulos, Alexandros, additional, Liakakos, Theodore, additional, Schizas, Dimitrios, additional, Baili, Efstratia, additional, Kapelouzou, Alkistis, additional, Valmasoni, Michele, additional, Pierobon, Elisa Sefora, additional, Capovilla, Giovanni, additional, Merigliano, Stefano, additional, Constantinoiu, Silviu, additional, Birla, Rodica, additional, Achim, Florin, additional, Rosianu, Cristian Gelu, additional, Hoara, Petre, additional, Castro, Raúl Guevara, additional, Salcedo, Andrés Felipe, additional, Negoi, Ionut, additional, Negoita, Valentina M., additional, Ciubotaru, Cezar, additional, Stoica, Bogdan, additional, Hostiuc, Sorin, additional, Colucci, Nicola, additional, Mönig, Stefan P., additional, Wassmer, Charles-Henri, additional, Meyer, Jeremy, additional, Takeda, Flavio Roberto, additional, Aissar Sallum, Rubens Antonio, additional, Ribeiro, Ulysses, additional, Cecconello, Ivan, additional, Toledo, Enrique, additional, Trugeda, Maria Soledad, additional, Fernández, María José, additional, Gil, Carolina, additional, Castanedo, Sonia, additional, Isik, Arda, additional, Kurnaz, Eray, additional, Videira, José Flávio, additional, Peyroteo, Mariana, additional, Canotilho, Rita, additional, Weindelmayer, Jacopo, additional, Giacopuzzi, Simone, additional, De Pasqual, Carlo Alberto, additional, Bruna, Marcos, additional, Mingol, Fernando, additional, Vaque, Javier, additional, Pérez, Carla, additional, Phillips, Alexander W., additional, Chmelo, Jakub, additional, Brown, Joshua, additional, Han, Laura E., additional, Gossage, James A., additional, Davies, Andrew R., additional, Baker, Cara R., additional, Kelly, Mark, additional, Saad, Mohamed, additional, Bernardi, Daniele, additional, Bonavina, Luigi, additional, Asti, Emanuele, additional, Riva, Carlo, additional, Scaramuzzo, Rosa, additional, Elhadi, Muhammed, additional, Ahmed, Hazem Abdelkarem, additional, Elhadi, Ahmed, additional, Elnagar, Faruk Ali, additional, Msherghi, Ahmed A.A., additional, Wills, Vanessa, additional, Campbell, Cassidy, additional, Cerdeira, Marisol Perez, additional, Whiting, Scott, additional, Merrett, Neil, additional, Das, Amitabha, additional, Apostolou, Christos, additional, Lorenzo, Aldenb, additional, Sousa, Fabiana, additional, Barbosa, José Adelino, additional, Devezas, Vítor, additional, Barbosa, Elisabete, additional, Fernandes, Cristina, additional, Smith, Garett, additional, Li, Edward Y., additional, Bhimani, Nazim, additional, Chan, Priscilla, additional, Kotecha, Krishna, additional, Hii, Michael W., additional, Ward, Salena M., additional, Johnson, MaryAnn, additional, Read, Matthew, additional, Chong, Lynn, additional, Hollands, Michael J., additional, Allaway, Matthew, additional, Richardson, Arthur, additional, Johnston, Emma, additional, Chen, Andy Z.L., additional, Kanhere, Harsh, additional, Prasad, Shalvin, additional, McQuillan, Patrick, additional, Surman, Tim, additional, Trochsler, MarkusI., additional, Schofield, W.A., additional, Ahmed, Syeda Khadijah, additional, Reid, Jessica L., additional, Harris, Mark C., additional, Gananadha, Sivakumar, additional, Farrant, Jessica, additional, Rodrigues, Nicole, additional, Fergusson, James, additional, Hindmarsh, Andrew, additional, Afzal, Zeeshan, additional, Safranek, Peter, additional, Sujendran, Vijay, additional, Rooney, Siobhan, additional, Loureiro, Carlos, additional, Fernández, Saioa Leturio, additional, Díez del Val, Ismael, additional, Jaunoo, Shameen, additional, Kennedy, Lauren, additional, Hussain, Ahmed, additional, Theodorou, Dimitrios, additional, Triantafyllou, Tania, additional, Theodoropoulos, Charalampos, additional, Palyvou, Theodora, additional, Ben Taher, Fatima Abdullah, additional, and Ekheel, Mustafa, additional

Published
2023
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5. Erratum to “Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue” [Eur J Surg Oncol 49 (5) (May 2023) 974–982]

Author

Heisterkamp, Joos, Polat, Fatih, Schouten, Jeroen, Singh, Pritam, Slootmans, Cettela A.M., Ultee, Gijs, Gisbertz, Suzanne S., Eshuis, Wietse J., Kalff, Marianne C., Feenstra, Minke L., van der Peet, Donald L., Stam, Wessel T., Van Etten, Boudewijn, Poelmann, Floris, Vuurberg, Nienke, Willem van den Berg, Jan, Martijnse, Ingrid S., Matthijsen, Robert M., Luyer, Misha, Curvers, Wout, Nieuwenhuijzen, Tom, Taselaar, Annick E., Kouwenhoven, Ewout A., Lubbers, Merel, Sosef, Meindert, Lecot, Frederik, Geraedts, Tessa C.M., van den Wildenberg, Frits, Kelder, Wendy, Baas, Peter C., de Haas, Job W.A., Hartgrink, Henk H., Bahadoer, Renu R., van Sandick, Johanna W., Hartemink, Koen J., Veenhof, Xander, Stockmann, Hein, Gorgec, Burak, Weeder, Pepijn, Wiezer, Marinus J., Genders, Charlotte M.S., Belt, Eric, Blomberg, Bjorn, van Duijvendijk, Peter, Claassen, Linda, Reetz, David, Steenvoorde, Pascal, Mastboom, Walter, Klein Ganseij, Henk Jan, van Dalsen, Annette D., Joldersma, Annalie, Zwakman, Marije, Groenendijk, Richard P.R., Montazeri, Mahsa, Mercer, Stuart, Knight, Benjamin, van Boxel, Gijs, McGregor, Richard J., Skipworth, Richard J.E., Frattini, Cristina, Bradley, Alice, Nilsson, Magnus, Hayami, Masaru, Huang, Biying, Bundred, James, Evans, Richard, Grimminger, Peter P., van der Sluis, Pieter C., Eren, Uzun, Saunders, John, Theophilidou, Elena, Khanzada, Zubair, Elliott, Jessie A., Ponten, Jeroen, King, Sinead, Reynolds, John V., Sgromo, Bruno, Akbari, Khalid, Shalaby, Samar, Gutschow, Christian A., Schmidt, Henner, Vetter, Diana, Moorthy, Krishna, Ibrahim, Mohamed A.H., Christodoulidis, Grigorious, Räsänen, Jari V., Kauppi, Juha, Söderström, Henna, Koshy, Renol, Manatakis, Dimitrios K., Korkolis, Dimitrios P., Balalis, Dimitrios, Rompu, Aliki, Alkhaffaf, Bilal, Alasmar, Mohamed, Arebi, Moaad, Piessen, Guillaume, Nuytens, Frederiek, Degisors, Sebastien, Ahmed, Ahmed, Boddy, Alex, Gandhi, Suraj, Fashina, Oluwatomini, Van Daele, Elke, Pattyn, Piet, Robb, William B., Arumugasamy, Mayilone, Al Azzawi, Mohammed, Whooley, Jack, Colak, Elif, Aybar, Engin, Sari, Ahmet C., Uyanik, Mustafa S., Ciftci, Ahmet B., Sayyed, Raza, Ayub, Bushra, Murtaza, Ghulam, Saeed, Aniqa, Ramesh, Priyanka, Charalabopoulos, Alexandros, Liakakos, Theodore, Schizas, Dimitrios, Baili, Efstratia, Kapelouzou, Alkistis, Valmasoni, Michele, Pierobon, Elisa Sefora, Capovilla, Giovanni, Merigliano, Stefano, Constantinoiu, Silviu, Birla, Rodica, Achim, Florin, Rosianu, Cristian Gelu, Hoara, Petre, Castro, Raúl Guevara, Salcedo, Andrés Felipe, Negoi, Ionut, Negoita, Valentina M., Ciubotaru, Cezar, Stoica, Bogdan, Hostiuc, Sorin, Colucci, Nicola, Mönig, Stefan P., Wassmer, Charles-Henri, Meyer, Jeremy, Takeda, Flavio Roberto, Aissar Sallum, Rubens Antonio, Ribeiro, Ulysses, Cecconello, Ivan, Toledo, Enrique, Trugeda, Maria Soledad, Fernández, María José, Gil, Carolina, Castanedo, Sonia, Isik, Arda, Kurnaz, Eray, Videira, José Flávio, Peyroteo, Mariana, Canotilho, Rita, Weindelmayer, Jacopo, Giacopuzzi, Simone, De Pasqual, Carlo Alberto, Bruna, Marcos, Mingol, Fernando, Vaque, Javier, Pérez, Carla, Phillips, Alexander W., Chmelo, Jakub, Brown, Joshua, Han, Laura E., Gossage, James A., Davies, Andrew R., Baker, Cara R., Kelly, Mark, Saad, Mohamed, Bernardi, Daniele, Bonavina, Luigi, Asti, Emanuele, Riva, Carlo, Scaramuzzo, Rosa, Elhadi, Muhammed, Ahmed, Hazem Abdelkarem, Elhadi, Ahmed, Elnagar, Faruk Ali, Msherghi, Ahmed A.A., Wills, Vanessa, Campbell, Cassidy, Cerdeira, Marisol Perez, Whiting, Scott, Merrett, Neil, Das, Amitabha, Apostolou, Christos, Lorenzo, Aldenb, Sousa, Fabiana, Barbosa, José Adelino, Devezas, Vítor, Barbosa, Elisabete, Fernandes, Cristina, Smith, Garett, Li, Edward Y., Bhimani, Nazim, Chan, Priscilla, Kotecha, Krishna, Hii, Michael W., Ward, Salena M., Johnson, MaryAnn, Read, Matthew, Chong, Lynn, Hollands, Michael J., Allaway, Matthew, Richardson, Arthur, Johnston, Emma, Chen, Andy Z.L., Kanhere, Harsh, Prasad, Shalvin, McQuillan, Patrick, Surman, Tim, Trochsler, MarkusI., Schofield, W.A., Ahmed, Syeda Khadijah, Reid, Jessica L., Harris, Mark C., Gananadha, Sivakumar, Farrant, Jessica, Rodrigues, Nicole, Fergusson, James, Hindmarsh, Andrew, Afzal, Zeeshan, Safranek, Peter, Sujendran, Vijay, Rooney, Siobhan, Loureiro, Carlos, Fernández, Saioa Leturio, Díez del Val, Ismael, Jaunoo, Shameen, Kennedy, Lauren, Hussain, Ahmed, Theodorou, Dimitrios, Triantafyllou, Tania, Theodoropoulos, Charalampos, Palyvou, Theodora, Ben Taher, Fatima Abdullah, Ekheel, Mustafa, Ubels, Sander, Matthée, Eric, Verstegen, Moniek, Klarenbeek, Bastiaan, Bouwense, Stefan, van Berge Henegouwen, Mark I., Daams, Freek, Dekker, Jan Willem T., van Det, Marc J., van Esser, Stijn, Griffiths, Ewen A., Haveman, Jan Willem, Nieuwenhuijzen, Grard, Siersema, Peter D., Wijnhoven, Bas, Hannink, Gerjon, van Workum, Frans, and Rosman, Camiel

Published
2023
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6. Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue

Author

Ubels, Sander, primary, Matthée, Eric, additional, Verstegen, Moniek, additional, Klarenbeek, Bastiaan, additional, Bouwense, Stefan, additional, van Berge Henegouwen, Mark I., additional, Daams, Freek, additional, Dekker, Jan Willem T., additional, van Det, Marc J., additional, van Esser, Stijn, additional, Griffiths, Ewen A., additional, Haveman, Jan Willem, additional, Nieuwenhuijzen, Grard, additional, Siersema, Peter D., additional, Wijnhoven, Bas, additional, Hannink, Gerjon, additional, van Workum, Frans, additional, Rosman, Camiel, additional, Heisterkamp, Joos, additional, Polat, Fatih, additional, Schouten, Jeroen, additional, Singh, Pritam, additional, Slootmans, Cettela A.M., additional, Ultee, Gijs, additional, Gisbertz, Suzanne S., additional, Eshuis, Wietse J., additional, Kalff, Marianne C., additional, Feenstra, Minke L., additional, van der Peet, Donald L., additional, Stam, Wessel T., additional, Van Etten, Boudewijn, additional, Poelmann, Floris, additional, Vuurberg, Nienke, additional, Willem van den Berg, Jan, additional, Martijnse, Ingrid S., additional, Matthijsen, Robert M., additional, Luyer, Misha, additional, Curvers, Wout, additional, Nieuwenhuijzen, Tom, additional, Taselaar, Annick E., additional, Kouwenhoven, Ewout A., additional, Lubbers, Merel, additional, Sosef, Meindert, additional, Lecot, Frederik, additional, Geraedts, Tessa C.M., additional, van den Wildenberg, Frits, additional, Kelder, Wendy, additional, Baas, Peter C., additional, de Haas, Job W.A., additional, Hartgrink, Henk H., additional, Bahadoer, Renu R., additional, van Sandick, Johanna W., additional, Hartemink, Koen J., additional, Veenhof, Xander, additional, Stockmann, Hein, additional, Gorgec, Burak, additional, Weeder, Pepijn, additional, Wiezer, Marinus J., additional, Genders, Charlotte M.S., additional, Belt, Eric, additional, Blomberg, Bjorn, additional, van Duijvendijk, Peter, additional, Claassen, Linda, additional, Reetz, David, additional, Steenvoorde, Pascal, additional, Mastboom, Walter, additional, Klein Ganseij, Henk Jan, additional, van Dalsen, Annette D., additional, Joldersma, Annalie, additional, Zwakman, Marije, additional, Groenendijk, Richard P.R., additional, Montazeri, Mahsa, additional, Mercer, Stuart, additional, Knight, Benjamin, additional, van Boxel, Gijs, additional, McGregor, Richard J., additional, Skipworth, Richard J.E., additional, Frattini, Cristina, additional, Bradley, Alice, additional, Nilsson, Magnus, additional, Hayami, Masaru, additional, Huang, Biying, additional, Bundred, James, additional, Evans, Richard, additional, Grimminger, Peter P., additional, van der Sluis, Pieter C., additional, Eren, Uzun, additional, Saunders, John, additional, Theophilidou, Elena, additional, Khanzada, Zubair, additional, Elliott, Jessie A., additional, Ponten, Jeroen, additional, King, Sinead, additional, Reynolds, John V., additional, Sgromo, Bruno, additional, Akbari, Khalid, additional, Shalaby, Samar, additional, Gutschow, Christian A., additional, Schmidt, Henner, additional, Vetter, Diana, additional, Moorthy, Krishna, additional, Ibrahim, Mohamed A.H., additional, Christodoulidis, Grigorious, additional, Räsänen, Jari V., additional, Kauppi, Juha, additional, Söderström, Henna, additional, Koshy, Renol, additional, Manatakis, Dimitrios K., additional, Korkolis, Dimitrios P., additional, Balalis, Dimitrios, additional, Rompu, Aliki, additional, Alkhaffaf, Bilal, additional, Alasmar, Mohamed, additional, Arebi, Moaad, additional, Piessen, Guillaume, additional, Nuytens, Frederiek, additional, Degisors, Sebastien, additional, Ahmed, Ahmed, additional, Boddy, Alex, additional, Gandhi, Suraj, additional, Fashina, Oluwatomini, additional, Van Daele, Elke, additional, Pattyn, Piet, additional, Robb, William B., additional, Arumugasamy, Mayilone, additional, Al Azzawi, Mohammed, additional, Whooley, Jack, additional, Colak, Elif, additional, Aybar, Engin, additional, Sari, Ahmet C., additional, Uyanik, Mustafa S., additional, Ciftci, Ahmet B., additional, Sayyed, Raza, additional, Ayub, Bushra, additional, Murtaza, Ghulam, additional, Saeed, Aniqa, additional, Ramesh, Priyanka, additional, Charalabopoulos, Alexandros, additional, Liakakos, Theodore, additional, Schizas, Dimitrios, additional, Baili, Efstratia, additional, Kapelouzou, Alkistis, additional, Valmasoni, Michele, additional, Pierobon, Elisa Sefora, additional, Capovilla, Giovanni, additional, Merigliano, Stefano, additional, Constantinoiu, Silviu, additional, Birla, Rodica, additional, Achim, Florin, additional, Rosianu, Cristian Gelu, additional, Hoara, Petre, additional, Castro, Raúl Guevara, additional, Salcedo, Andrés Felipe, additional, Negoi, Ionut, additional, Negoita, Valentina M., additional, Ciubotaru, Cezar, additional, Stoica, Bogdan, additional, Hostiuc, Sorin, additional, Colucci, Nicola, additional, Mönig, Stefan P., additional, Wassmer, Charles-Henri, additional, Meyer, Jeremy, additional, Takeda, Flavio Roberto, additional, Aissar Sallum, Rubens Antonio, additional, Ribeiro, Ulysses, additional, Cecconello, Ivan, additional, Toledo, Enrique, additional, Trugeda, Maria Soledad, additional, Fernández, María José, additional, Gil, Carolina, additional, Castanedo, Sonia, additional, Isik, Arda, additional, Kurnaz, Eray, additional, Videira, José Flávio, additional, Peyroteo, Mariana, additional, Canotilho, Rita, additional, Weindelmayer, Jacopo, additional, Giacopuzzi, Simone, additional, De Pasqual, Carlo Alberto, additional, Bruna, Marcos, additional, Mingol, Fernando, additional, Vaque, Javier, additional, Pérez, Carla, additional, Phillips, Alexander W., additional, Chmelo, Jakub, additional, Brown, Joshua, additional, Han, Laura E., additional, Gossage, James A., additional, Davies, Andrew R., additional, Baker, Cara R., additional, Kelly, Mark, additional, Saad, Mohamed, additional, Bernardi, Daniele, additional, Bonavina, Luigi, additional, Asti, Emanuele, additional, Riva, Carlo, additional, Scaramuzzo, Rosa, additional, Elhadi, Muhammed, additional, Ahmed, Hazem Abdelkarem, additional, Elhadi, Ahmed, additional, Elnagar, Faruk Ali, additional, Msherghi, Ahmed A.A., additional, Wills, Vanessa, additional, Campbell, Cassidy, additional, Cerdeira, Marisol Perez, additional, Whiting, Scott, additional, Merrett, Neil, additional, Das, Amitabha, additional, Apostolou, Christos, additional, Lorenzo, Aldenb, additional, Sousa, Fabiana, additional, Barbosa, José Adelino, additional, Devezas, Vítor, additional, Barbosa, Elisabete, additional, Fernandes, Cristina, additional, Smith, Garett, additional, Li, Edward Y., additional, Bhimani, Nazim, additional, Chan, Priscilla, additional, Kotecha, Krishna, additional, Hii, Michael W., additional, Ward, Salena M., additional, Johnson, MaryAnn, additional, Read, Matthew, additional, Chong, Lynn, additional, Hollands, Michael J., additional, Allaway, Matthew, additional, Richardson, Arthur, additional, Johnston, Emma, additional, Chen, Andy Z.L., additional, Kanhere, Harsh, additional, Prasad, Shalvin, additional, McQuillan, Patrick, additional, Surman, Tim, additional, Trochsler, MarkusI., additional, Schofield, W.A., additional, Ahmed, Syeda Khadijah, additional, Reid, Jessica L., additional, Harris, Mark C., additional, Gananadha, Sivakumar, additional, Farrant, Jessica, additional, Rodrigues, Nicole, additional, Fergusson, James, additional, Hindmarsh, Andrew, additional, Afzal, Zeeshan, additional, Safranek, Peter, additional, Sujendran, Vijay, additional, Rooney, Siobhan, additional, Loureiro, Carlos, additional, Fernández, Saioa Leturio, additional, Díez del Val, Ismael, additional, Jaunoo, Shameen, additional, Kennedy, Lauren, additional, Hussain, Ahmed, additional, Theodorou, Dimitrios, additional, Triantafyllou, Tania, additional, Theodoropoulos, Charalampos, additional, Palyvou, Theodora, additional, Ben Taher, Fatima Abdullah, additional, and Ekheel, Mustafa, additional

Published
2023
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7. 411. MAJOR INTRAOPERATIVE COMPLICATIONS IN MINIMALLY INVASIVE ESOPHAGECTOMIES

Author

Söderström, Henna, primary, Moons, Johnny, additional, Nafteux, Philippe, additional, Uzun, Eren, additional, Grimminger, Peter, additional, Luyer, Misha DP, additional, Nieuwenhuijzen, Grard AP, additional, Nilsson, Magnus, additional, Hayami, Masaru, additional, Degisors, De Sebastien, additional, Piessen, Guillaume, additional, Vanommeslaeghe, Hanne, additional, Van Daele, Elke, additional, Cheong, Edward, additional, Gutschow, Christian A, additional, Vetter, Diana, additional, Schuring, Nannet, additional, Gisbertz, Suzanne, additional, and Räsänen, Jari, additional

Published
2022
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9. Genomic profiles of primary and metastatic esophageal adenocarcinoma identified via digital sorting of pure cell populations: results from a case report

Author

Isidori, Federica, Malvi, Deborah, Fittipaldi, Silvia, Forcato, Claudio, Bozzarelli, Isotta, Sala, Claudia, Raulli, Giovanni, D'Errico, Antonia, Fiorentino, Michelangelo, Seri, Marco, Krishnadath, Kausilia K., Bonora, Elena, Mattioli, Sandro, Lugaresi, Maria Luisa, D'Errico, Antonietta, Castellani, Gastone, Fiocca, Roberto, Mastracci, Luca, Räsänen, Jari, Söderström, Henna, CCA - Imaging and biomarkers, Gastroenterology and Hepatology, AGEM - Re-generation and cancer of the digestive system, Isidori, Federica, Malvi, Deborah, Fittipaldi, Silvia, Forcato, Claudio, Bozzarelli, Isotta, Sala, Claudia, Raulli, Giovanni, D'Errico, Antonia, Fiorentino, Michelangelo, Seri, Marco, Krishnadath, Kausilia K., Bonora, Elena, Mattioli, Sandro, Lugaresi, Maria Luisa, Castellani, Gastone, Fiocca, Roberto, Mastracci, Luca, Räsänen, Jari, and Söderström, Henna

Subjects
0301 basic medicine, Cancer Research, Esophageal Neoplasms, Receptor, ErbB-2, Biopsy, medicine.medical_treatment, Case Report, Somatic evolution in cancer, Targeted therapy, ErbB-2, 0302 clinical medicine, Surgical oncology, Neoplasm Metastasis, Stage (cooking), Esophageal Neoplasm, Tumor, medicine.diagnostic_test, Single Nucleotide, Genomics, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Neoplasm Metastasi, Oncology, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, Esophageal adenocarcinoma, Human, Receptor, Stromal cell, Polymorphism, Single Nucleotide, lcsh:RC254-282, Clonal Evolution, 03 medical and health sciences, Genetic, Next generation sequencing, Biomarkers, Tumor, Genetics, medicine, Humans, Polymorphism, Neoplasm Staging, Digital cell sorting, Esophageal adenocarcinoma, Next generation sequencing, Adenocarcinoma, Biomarkers, Tumor, Biopsy, Clonal Evolution, Esophageal Neoplasms, Female, Humans, Immunohistochemistry, Mutation, Neoplasm Metastasis, Neoplasm Staging, Polymorphism, Single Nucleotide, Receptor, ErbB-2, Genomics, Whole Genome Sequencing, Whole Genome Sequencing, business.industry, Cancer, medicine.disease, Digital cell sorting, 030104 developmental biology, Mutation, Genomic, Cancer research, business, Biomarkers
Abstract

Background We report on a female patient who underwent primary radical resection for a stage 2B Her-2-positive Barrett’s-type esophageal adenocarcinoma (EAC). Despite Her-2 targeted therapy, her disease recurred and required repeated metastectomies. Case presentation Digital cell sorting and targeted sequencing of cancer sub-clones from EAC and metastases revealed a completely mutated TP53, whereas the sorted stromal cells were wild-type. Her-2 amplification was significantly lower in the metastases when the patient became therapy-resistant. Conclusions The mechanism of therapy resistance illustrated by this case could only be detected through accurate analysis of tumor sub-populations. Investigating tumor sub-populations of recurrent disease is important for adjusting therapy in recurrent EAC. Electronic supplementary material The online version of this article (10.1186/s12885-018-4789-4) contains supplementary material, which is available to authorized users.

Published
2018
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10. Cohort profile: a nationwide population-based retrospective assessment of oesophageal cancer in the Finnish National Esophago-Gastric Cancer Cohort (FINEGO)

Author

Söderström, Henna K, primary, Räsänen, Jari, additional, Saarnio, Juha, additional, Toikkanen, Vesa, additional, Tyrväinen, Tuula, additional, Rantanen, Tuomo, additional, Valtola, Antti, additional, Ohtonen, Pasi, additional, Pääaho, Minna, additional, Kokkola, Arto, additional, Kallio, Raija, additional, Karttunen, Tuomo J, additional, Pohjanen, Vesa-Matti, additional, Ristimäki, Ari, additional, Laine, Simo, additional, Sihvo, Eero, additional, and Kauppila, Joonas H, additional

Published
2020
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11. P119 SURGICAL OUTCOMES AFTER ESOPHAGECTOMY IN THE ELDERLY POPULATION - A SINGLE CENTER COHORT STUDY

Author

Andersson Saana, Kauppi Juha, Ilonen Ilkka, Söderström Henna, and Räsänen Jari

Subjects
medicine.medical_specialty, business.industry, General surgery, medicine.medical_treatment, Gastroenterology, General Medicine, Single Center, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Esophagectomy, 030220 oncology & carcinogenesis, Elderly population, medicine, 030211 gastroenterology & hepatology, business, Cohort study
Abstract

Aim To evaluate morbidity and mortality after esophagectomy among elderly patients Background & Methods Esophagectomy is associated with significant morbidity1, and with the aging population we are faced with an increasing number of elderly patients eligible for surgery. In this retrospective study we analyzed both minor and major postoperative complications (Clavidien-Dindo II-V), in-hospital and 90-day mortality, and overall survival in all carcinoma patients ≥75 yo undergoing esophagectomy for cancer between 2009 and 2018 at a high-volume center. Results 47 patients underwent esophagectomy during the 10-yr. period, 95,7% either minimally invasively or with a hybrid approach. Median age was 77, and the oldest patient 85 yo. The majority were in otherwise good health, 39 had an ASA score of 1-2, and all but one was ECOG 0. 70% had adenocarcinomas, and 70% received neoadjuvant treatment. 68,1% of the patients suffered some sort of complication. 19 patients (40,4%) had a C-D III-IV complication, 9 of which were pulmonary requiring a median of 5 days in the ICU. Only 4 patients (8,5%) had anastomotic leakage requiring an intervention, 2 were managed endoscopically, 1 early dehiscence was sutured and one required a revision and LD plasty. One patient had non-fatal gastric tube necrosis that was excised. Atrial fibrillation (34%) was the most common but easily managed issue, followed by pulmonary complications (C-D II 5pts /10,6%, C-D III-IV 10 pts / 21,3%). We had 3 re-operations for bowl herniation, and one for bleeding. Our in-hospital and 90-day mortality were 0%, in spite of the high complication rate. 63,8% were discharged home. Mean and median survival times 68,2 mo. and 47 mo., respectively. At time of follow up, 28 patients (59,6%) were still alive. Conclusion Esophagectomy comes with high morbidity, but with acceptable long term results it should be considered for elderly patients otherwise fit for surgery. Our results show that in select cases age is just a number 1. Low DE, Kuppusamy MK, Alderson D, Cecconello I, Chang AC, Darling G, Davies A, D'Journo XB, Gisbertz SS, Griffin SM, Hardwick R, Hoelscher A, et al. Benchmarking Complications Associated with Esophagectomy. Ann Surg 2017;:1.

Published
2019
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13. PS02.046: UNRAVELING TUMOR HETEROGENEITY OF ESOPHAGEAL ADENOCARCINOMA (EAC) THROUGH HIGH-THROUGHPUT OF SORTED TUMOR CELL POPULATIONS

Author

Bonora, Elena, primary, Isidori, Federica, additional, Bozzarelli, Isotta, additional, Lugaresi, Marialuisa, additional, Malvi, Deborah, additional, Söderström, Henna, additional, Bolognesi, Chiara, additional, Forcato, Claudio, additional, D’Errico, Antonietta, additional, Fiocca, Roberto, additional, Seri, Marco, additional, Krishnadath, Kausilia, additional, and Mattioli, Sandro, additional

Published
2018
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15. Targeted Sequencing of Sorted Esophageal Adenocarcinoma Cells Unveils Known and Novel Mutations in the Separated Subpopulations

Author

Marco Seri, Luca Mastracci, Isotta Bozzarelli, Marialuisa Lugaresi, Jari Räsänen, Deborah Malvi, Henna Söderström, Chiara Molinari, Antonia D'Errico, Federica Isidori, Sandro Mattioli, Elena Bonora, Roberto Fiocca, Kausilia K. Krishnadath, Gastroenterology and Hepatology, CCA - Cancer biology and immunology, Amsterdam Gastroenterology Endocrinology Metabolism, Isidori, Federica, Bozzarelli, Isotta, Mastracci, Luca, Malvi, Deborah, Lugaresi, Marialuisa, Molinari, Chiara, Söderström, Henna, Räsänen, Jari, D'Errico, Antonia, Fiocca, Roberto, Seri, Marco, Krishnadath, Kausilia K., Bonora, Elena, and Mattioli, Sandro

Subjects
Adult, Male, Esophageal Mucosa, Stromal cell, esophageal adenocarcinoma, Esophageal Neoplasms, DNA Mutational Analysis, Cell Separation, Adenocarcinoma, Disease-Free Survival, Article, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Esophagus, Humans, Medicine, NGS, single cell sorting, Lymph node, Aged, Aged, 80 and over, business.industry, Genetic heterogeneity, Gastroenterology, High-Throughput Nucleotide Sequencing, Cancer, Middle Aged, Cell sorting, medicine.disease, Immunohistochemistry, Esophagectomy, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Mutation, Cancer cell, Cancer research, Female, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

INTRODUCTION: Our study aimed at investigating tumor heterogeneity in esophageal adenocarcinoma (EAC) cells regarding clinical outcomes. METHODS: Thirty-eight surgical EAC cases who underwent gastroesophageal resection with lymph node dissection in 3 university centers were included. Archival material was analyzed via high-throughput cell sorting technology and targeted sequencing of 63 cancer-related genes. Low-pass sequencing and immunohistochemistry (IHC) were used to validate the results. Results Thirty-five of 38 EACs carried at least one somatic mutation that was absent in the stromal cells; 73.7%, 10.5%, and 10.5% carried mutations in tumor protein 53, cyclin dependent kinase inhibitor 2A, and SMAD family member 4, respectively. In addition, 2 novel mutations were found for hepatocyte nuclear factor-1 alpha in 2 of 38 cases. Tumor protein 53 gene abnormalities were more informative than p53 IHC. Conversely, loss of SMAD4 was more frequently noted with IHC (53%) and was associated with a higher recurrence rate (P = 0.015). Only through cell sorting we were able to detect the presence of hyperdiploid and pseudodiploid subclones in 7 EACs that exhibited different mutational loads and/or additional copy number amplifications, indicating the high genetic heterogeneity of these cancers. DISCUSSION: Selective cell sorting allowed the characterization of multiple molecular defects in EAC subclones that were missed in a significant number of cases when whole-tumor samples were analyzed. Therefore, this approach can reveal subtle differences in cancer cell subpopulations. Future studies are required to investigate whether these subclones are responsible for treatment response and disease recurrence.

Published
2020

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