365 results on '"Sämann P"'
Search Results
2. Ambitwistor Yang-Mills Theory Revisited
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Borsten, Leron, Jurco, Branislav, Kim, Hyungrok, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics - Abstract
Inspired by the Movshev-Mason-Skinner Cauchy-Riemann (CR) ambitwistor approach, we provide a rigorous yet elementary construction of a twisted CR holomorphic Chern-Simons action on CR ambitwistor space for maximally supersymmetric Yang-Mills theory on four-dimensional Euclidean space. The key ingredient in our discussion is the homotopy algebraic perspective on perturbative quantum field theory. Using this technology, we show that both theories are semi-classically equivalent, that is, we construct a quasi-isomorphism between the cyclic $L_\infty$-algebras governing both field theories. This confirms a conjecture from the literature. Furthermore, we also show that the Yang-Mills action is obtained by integrating out an infinite tower of auxiliary fields in the Chern-Simons action, that is, the two theories are related by homotopy transfer. Given its simplicity, this Chern-Simons action should form a fruitful starting point for analysing perturbative properties of Yang-Mills theory., Comment: 42 pages
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- 2024
3. A nonlinear d'Alembert comparison theorem and causal differential calculus on metric measure spacetimes
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Beran, Tobias, Braun, Mathias, Calisti, Matteo, Gigli, Nicola, McCann, Robert J., Ohanyan, Argam, Rott, Felix, and Sämann, Clemens
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Mathematics - Differential Geometry ,General Relativity and Quantum Cosmology ,Mathematical Physics ,Mathematics - Metric Geometry ,51K10, 83C75 (Primary), 35J92, 35Q75, 49Q22, 53C21, 53C50 (Secondary) - Abstract
We introduce a variational first-order Sobolev calculus on metric measure spacetimes. The key object is the maximal weak subslope of an arbitrary causal function, which plays the role of the (Lorentzian) modulus of its differential. It is shown to satisfy certain chain and Leibniz rules, certify a locality property, and be compatible with its smooth analog. In this setup, we propose a quadraticity condition termed infinitesimal Minkowskianity, which singles out genuinely Lorentzian structures among Lorentz-Finsler spacetimes. Moreover, we establish a comparison theorem for a nonlinear yet elliptic $p$-d'Alembertian in a weak form under the timelike measure contraction property. As a particular case, this extends Eschenburg's classical estimate past the timelike cut locus., Comment: 132 pages. Comments welcome
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- 2024
4. Topological Classification of Symmetry Breaking and Vacuum Degeneracy
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Fischer, Simon-Raphael, Farahani, Mehran Jalali, Kim, Hyungrok, and Saemann, Christian
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High Energy Physics - Theory ,Mathematical Physics ,Mathematics - Differential Geometry ,53C12 (Primary) 70S15, 81T13, 57R30 (Secondary) - Abstract
We argue that a general system of scalar fields and gauge fields manifesting vacuum degeneracy induces a principal groupoid bundle over spacetime and that the pattern of spontaneous symmetry breaking and the Higgs mechanism are encoded by the singular foliation canonically induced on the moduli space of scalar vacuum expectation values by the Lie groupoid structure. Recent mathematical results in the classification of singular foliations then provide a qualitative classification of the possible patterns of vacuum degeneracy., Comment: 7 pages, 5 figures, 1 table
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- 2024
5. Adjusted Connections I: Differential Cocycles for Principal Groupoid Bundles with Connection
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Fischer, Simon-Raphael, Farahani, Mehran Jalali, Kim, Hyungrok, and Saemann, Christian
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Mathematics - Differential Geometry ,High Energy Physics - Theory ,Mathematical Physics - Abstract
We develop a new perspective on principal bundles with connection as morphisms from the tangent bundle of the underlying manifold to a classifying dg-Lie groupoid. This groupoid can be identified with a lift of the inner homomorphisms groupoid arising in \v{S}evera's differentiation procedure of Lie quasi-groupoids. Our new perspective readily extends to principal groupoid bundles, but requires an adjustment, an additional datum familiar from higher gauge theory. We show that for Lie groupoids, the additional adjustment data amounts to a Cartan connection. The resulting adjusted connections naturally provide a global formulation of the kinematical data of curved Yang-Mills-Higgs theories as described by Kotov-Strobl (arXiv:1510.07654) and Fischer (arXiv:2104.02175)., Comment: v2: 1+77 pages, full identification of adjustments with Cartan connections, presentation improved, typos fixed, references added
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- 2024
6. A brief introduction to non-regular spacetime geometry
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Sämann, Clemens
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General Relativity and Quantum Cosmology ,Mathematical Physics ,Mathematics - Differential Geometry ,Mathematics - Metric Geometry ,51K10, 53C23, 53C50, 53B30, 53C80, 83C99 - Abstract
We give a brief non-technical introduction to non-regular spacetime geometry. In particular, we discuss how curvature, and hence gravity, can be defined without a smooth (differential geometric) calculus., Comment: 19 pages, 3 Figures; invited article for International Mathematical News, the journal of the Austrian Mathematical Society
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- 2024
7. Huntingtin CAG repeat size variations below the Huntington’s disease threshold: associations with depression, anxiety and basal ganglia structure
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Vater, Magdalena, Rost, Nicolas, Eckstein, Gertrud, Sauer, Susann, Tontsch, Alina, Erhardt, Angelika, Lucae, Susanne, Brückl, Tanja, Klopstock, Thomas, Sämann, Philipp G., and Binder, Elisabeth B.
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- 2024
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8. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
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García-Marín, Luis M., Campos, Adrian I., Diaz-Torres, Santiago, Rabinowitz, Jill A., Ceja, Zuriel, Mitchell, Brittany L., Grasby, Katrina L., Thorp, Jackson G., Agartz, Ingrid, Alhusaini, Saud, Ames, David, Amouyel, Philippe, Andreassen, Ole A., Arfanakis, Konstantinos, Arias-Vasquez, Alejandro, Armstrong, Nicola J., Athanasiu, Lavinia, Bastin, Mark E., Beiser, Alexa S., Bennett, David A., Bis, Joshua C., Boks, Marco P. M., Boomsma, Dorret I., Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Burkhardt, Ralph, Cahn, Wiepke, Calhoun, Vince D., Carmichael, Owen T., Chakravarty, Mallar, Chen, Qiang, Ching, Christopher R. K., Cichon, Sven, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dale, Anders M., Smith, George Davey, de Geus, Eco J. C., De Jager, Philip L., de Zubicaray, Greig I., Debette, Stéphanie, DeCarli, Charles, Depondt, Chantal, Desrivières, Sylvane, Djurovic, Srdjan, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fernández, Guillén, Filippi, Irina, Fisher, Simon E., Fleischman, Debra A., Fletcher, Evan, Fornage, Myriam, Forstner, Andreas J., Francks, Clyde, Franke, Barbara, Ge, Tian, Goldman, Aaron L., Grabe, Hans J., Green, Robert C., Grimm, Oliver, Groenewold, Nynke A., Gruber, Oliver, Gudnason, Vilmundur, Håberg, Asta K., Haukvik, Unn K., Heinz, Andreas, Hibar, Derrek P., Hilal, Saima, Himali, Jayandra J., Ho, Beng-Choon, Hoehn, David F., Hoekstra, Pieter J., Hofer, Edith, Hoffmann, Wolfgang, Holmes, Avram J., Homuth, Georg, Hosten, Norbert, Ikram, M. Kamran, Ipser, Jonathan C., Jack Jr, Clifford R., Jahanshad, Neda, Jönsson, Erik G., Kahn, Rene S., Kanai, Ryota, Klein, Marieke, Knol, Maria J., Launer, Lenore J., Lawrie, Stephen M., Hellard, Stephanie Le, Lee, Phil H., Lemaître, Hervé, Li, Shuo, Liewald, David C. M., Lin, Honghuang, Longstreth, Jr, W. T., Lopez, Oscar L., Luciano, Michelle, Maillard, Pauline, Marquand, Andre F., Martin, Nicholas G., Martinot, Jean-Luc, Mather, Karen A., Mattay, Venkata S., McMahon, Katie L., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mirza-Schreiber, Nazanin, Milaneschi, Yuri, Mosley, Thomas H., Mühleisen, Thomas W., Müller-Myhsok, Bertram, Maniega, Susana Muñoz, Nauck, Matthias, Nho, Kwangsik, Niessen, Wiro J., Nöthen, Markus M., Nyquist, Paul A., Oosterlaan, Jaap, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W. J. H., Pike, G. Bruce, Psaty, Bruce M., Pütz, Benno, Reppermund, Simone, Rietschel, Marcella D., Risacher, Shannon L., Romanczuk-Seiferth, Nina, Romero-Garcia, Rafael, Roshchupkin, Gennady V., Rotter, Jerome I., Sachdev, Perminder S., Sämann, Philipp G., Saremi, Arvin, Sargurupremraj, Muralidharan, Saykin, Andrew J., Schmaal, Lianne, Schmidt, Helena, Schmidt, Reinhold, Schofield, Peter R., Scholz, Markus, Schumann, Gunter, Schwarz, Emanuel, Shen, Li, Shin, Jean, Sisodiya, Sanjay M., Smith, Albert V., Smoller, Jordan W., Soininen, Hilkka S., Steen, Vidar M., Stein, Dan J., Stein, Jason L., Thomopoulos, Sophia I., Toga, Arthur W., Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Valdes-Hernandez, Maria C., van ′t Ent, Dennis, van Bokhoven, Hans, van der Meer, Dennis, van der Wee, Nic J. A., Vázquez-Bourgon, Javier, Veltman, Dick J., Vernooij, Meike W., Villringer, Arno, Vinke, Louis N., Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M., Weinberger, Daniel R., Weiner, Michael W., Wen, Wei, Westlye, Lars T., Westman, Eric, White, Tonya, Witte, A. Veronica, Wolf, Christiane, Yang, Jingyun, Zwiers, Marcel P., Ikram, M. Arfan, Seshadri, Sudha, Thompson, Paul M., Satizabal, Claudia L., Medland, Sarah E., and Rentería, Miguel E.
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- 2024
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9. Higher Gauge Theory
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Borsten, Leron, Farahani, Mehran Jalali, Jurco, Branislav, Kim, Hyungrok, Narozny, Jiri, Rist, Dominik, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics ,Mathematics - Differential Geometry - Abstract
This is an invited survey article on higher gauge theory for the Encyclopedia of Mathematical Physics, 2nd edition. In particular, we provide a lightning introduction to higher structures and to the construction of the kinematical data of higher gauge theories, i.e. connections on higher principal bundles. We also summarise the most important applications and dynamical principles that have appeared in the literature, and we close with comments on related areas., Comment: 36 pages text, 17 pages references
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- 2024
10. Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk.
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Zhu, Yinghan, Maikusa, Norihide, Radua, Joaquim, Sämann, Philipp, Fusar-Poli, Paolo, Agartz, Ingrid, Andreassen, Ole, Bachman, Peter, Baeza, Inmaculada, Chen, Xiaogang, Choi, Sunah, Corcoran, Cheryl, Ebdrup, Bjørn, Fortea, Adriana, Garani, Ranjini, Glenthøj, Birte, Glenthøj, Louise, Haas, Shalaila, Hamilton, Holly, Hayes, Rebecca, He, Ying, Heekeren, Karsten, Kasai, Kiyoto, Katagiri, Naoyuki, Kim, Minah, Kristensen, Tina, Kwon, Jun, Lawrie, Stephen, Lebedeva, Irina, Lee, Jimmy, Loewy, Rachel, Mathalon, Daniel, McGuire, Philip, Mizrahi, Romina, Mizuno, Masafumi, Møller, Paul, Nemoto, Takahiro, Nordholm, Dorte, Omelchenko, Maria, Raghava, Jayachandra, Røssberg, Jan, Rössler, Wulf, Salisbury, Dean, Sasabayashi, Daiki, Smigielski, Lukasz, Sugranyes, Gisela, Takahashi, Tsutomu, Tamnes, Christian, Tang, Jinsong, Theodoridou, Anastasia, Tomyshev, Alexander, Uhlhaas, Peter, Værnes, Tor, van Amelsvoort, Therese, Waltz, James, Westlye, Lars, Zhou, Juan, Thompson, Paul, Hernaus, Dennis, Jalbrzikowski, Maria, and Koike, Shinsuke
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Humans ,Psychotic Disorders ,Magnetic Resonance Imaging ,Male ,Female ,Brain ,Neuroimaging ,Adult ,Young Adult ,Machine Learning ,Adolescent ,Prodromal Symptoms - Abstract
Machine learning approaches using structural magnetic resonance imaging (sMRI) can be informative for disease classification, although their ability to predict psychosis is largely unknown. We created a model with individuals at CHR who developed psychosis later (CHR-PS+) from healthy controls (HCs) that can differentiate each other. We also evaluated whether we could distinguish CHR-PS+ individuals from those who did not develop psychosis later (CHR-PS-) and those with uncertain follow-up status (CHR-UNK). T1-weighted structural brain MRI scans from 1165 individuals at CHR (CHR-PS+, n = 144; CHR-PS-, n = 793; and CHR-UNK, n = 228), and 1029 HCs, were obtained from 21 sites. We used ComBat to harmonize measures of subcortical volume, cortical thickness and surface area data and corrected for non-linear effects of age and sex using a general additive model. CHR-PS+ (n = 120) and HC (n = 799) data from 20 sites served as a training dataset, which we used to build a classifier. The remaining samples were used external validation datasets to evaluate classifier performance (test, independent confirmatory, and independent group [CHR-PS- and CHR-UNK] datasets). The accuracy of the classifier on the training and independent confirmatory datasets was 85% and 73% respectively. Regional cortical surface area measures-including those from the right superior frontal, right superior temporal, and bilateral insular cortices strongly contributed to classifying CHR-PS+ from HC. CHR-PS- and CHR-UNK individuals were more likely to be classified as HC compared to CHR-PS+ (classification rate to HC: CHR-PS+, 30%; CHR-PS-, 73%; CHR-UNK, 80%). We used multisite sMRI to train a classifier to predict psychosis onset in CHR individuals, and it showed promise predicting CHR-PS+ in an independent sample. The results suggest that when considering adolescent brain development, baseline MRI scans for CHR individuals may be helpful to identify their prognosis. Future prospective studies are required about whether the classifier could be actually helpful in the clinical settings.
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- 2024
11. Cut-and-paste for impulsive gravitational waves with $\Lambda$: The mathematical analysis
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Sämann, Clemens, Schinnerl, Benedict, Steinbauer, Roland, and Švarc, Robert
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General Relativity and Quantum Cosmology ,Mathematical Physics ,83C15, 83C35, 46F30, 46F10, 83C10, 34A36 - Abstract
Impulsive gravitational waves are theoretical models of short but violent bursts of gravitational radiation. They are commonly described by two distinct spacetime metrics, one of local Lipschitz regularity, the other one even distributional. These two metrics are thought to be `physically equivalent' since they can be formally related by a `discontinuous coordinate transformation'. In this paper we provide a mathematical analysis of this issue for the entire class of nonexpanding impulsive gravitational waves propagating in a background spacetime of constant curvature. We devise a natural geometric regularisation procedure to show that the notorious change of variables arises as the distributional limit of a family of smooth coordinate transformations. In other words, we establish that both spacetimes arise as distributional limits of a smooth sandwich wave taken in different coordinate systems which are diffeomorphically related., Comment: 26 pages
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- 2023
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12. Online Out-of-Domain Detection for Automated Driving
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Sämann, Timo and Groß, Horst-Michael
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Ensuring safety in automated driving is a major challenge for the automotive industry. Special attention is paid to artificial intelligence, in particular to Deep Neural Networks (DNNs), which is considered a key technology in the realization of highly automated driving. DNNs learn from training data, which means that they only achieve good accuracy within the underlying data distribution of the training data. When leaving the training domain, a distributional shift is caused, which can lead to a drastic reduction of accuracy. In this work, we present a proof of concept for a safety mechanism that can detect the leaving of the domain online, i.e. at runtime. In our experiments with the Synthia data set we can show that a 100 % correct detection of whether the input data is inside or outside the domain is achieved. The ability to detect when the vehicle leaves the domain can be an important requirement for certification., Comment: Machine Learning in Certified Systems (MLCS) Workshop, 14.-15.01.2021
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- 2023
13. Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures
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Belov, Vladimir, Erwin-Grabner, Tracy, Aghajani, Moji, Aleman, Andre, Amod, Alyssa R., Basgoze, Zeynep, Benedetti, Francesco, Besteher, Bianca, Bülow, Robin, Ching, Christopher R. K., Connolly, Colm G., Cullen, Kathryn, Davey, Christopher G., Dima, Danai, Dols, Annemiek, Evans, Jennifer W., Fu, Cynthia H. Y., Gonul, Ali Saffet, Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke, Hamilton, J Paul, Harrison, Ben J., Ho, Tiffany C., Mwangi, Benson, Jaworska, Natalia, Jahanshad, Neda, Klimes-Dougan, Bonnie, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Li, Meng, Linden, David E. J., MacMaster, Frank P., Mehler, David M. A., Melloni, Elisa, Mueller, Bryon A., Ojha, Amar, Oudega, Mardien L., Penninx, Brenda W. J. H., Poletti, Sara, Pomarol-Clotet, Edith, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Sacchet, Matthew D., Sämann, Philipp G., Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Thomopoulos, Sophia I., Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J. A., Völzke, Henry, Whittle, Sarah, Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Yang, Tony T., Zarate, Carlos, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., and Goya-Maldonado, Roberto
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- 2024
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14. Assessing hypo-arousal during reward anticipation with pupillometry in patients with major depressive disorder: replication and correlations with anhedonia
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Brendler, Andy, Schneider, Max, Elbau, Immanuel G., Sun, Rui, Nantawisarakul, Taechawidd, Pöhlchen, Dorothee, Brückl, Tanja, Czisch, Michael, Sämann, Philipp G., Lee, Michael D., and Spoormaker, Victor I.
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- 2024
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15. Double-Copying Self-Dual Yang-Mills Theory to Self-Dual Gravity on Twistor Space
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Borsten, Leron, Jurco, Branislav, Kim, Hyungrok, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We construct a simple Lorentz-invariant action for maximally supersymmetric self-dual Yang-Mills theory that manifests colour-kinematics duality. We also show that this action double copies to a known action for maximally supersymmetric self-dual gravity. Both actions live on twistor space and illustrate nicely the homotopy algebraic perspective on the double copy presented in arXiv:2307.02563. This example is particularly interesting as the involved Hopf algebra controlling the momentum dependence is non-commutative and suggests a generalisation to gauged maximally supersymmetric self-dual gravity., Comment: 19 pages
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- 2023
16. Double Copy from Tensor Products of Metric BV${}^{\color{gray} \blacksquare}$-algebras
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Borsten, Leron, Jurco, Branislav, Kim, Hyungrok, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics - Abstract
Field theories with kinematic Lie algebras, such as field theories featuring colour-kinematics duality, possess an underlying algebraic structure known as BV${}^{\color{gray} \blacksquare}$-algebra. If, additionally, matter fields are present, this structure is supplemented by a module for the BV${}^{\color{gray} \blacksquare}$-algebra. We explain this perspective, expanding on our previous work and providing many additional mathematical details. We also show how the tensor product of two metric BV${}^{\color{gray} \blacksquare}$-algebras yields the action of a new syngamy field theory, a construction which comprises the familiar double copy construction. As examples, we discuss various scalar field theories, Chern-Simons theory, self-dual Yang-Mills theory, and the pure spinor formulations of both M2-brane models and supersymmetric Yang-Mills theory. The latter leads to a new cubic pure spinor action for ten-dimensional supergravity. We also give a homotopy-algebraic perspective on colour-flavour-stripping, obtain a new restricted tensor product over a wide class of bialgebras, and we show that any field theory (even one without colour-kinematics duality) comes with a kinematic $L_\infty$-algebra., Comment: v3: 98 pages, references added, typos fixed, version published in Fortschritte der Physik
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- 2023
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17. Field Theory Equivalences as Spans of $L_\infty$-algebras
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Farahani, Mehran Jalali, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics - Abstract
Semi-classically equivalent field theories are related by a quasi-isomorphism between their underlying $L_\infty$-algebras, but such a quasi-isomorphism is not necessarily a homotopy transfer. We demonstrate that all quasi-isomorphisms can be lifted to spans of $L_\infty$-algebras in which the quasi-isomorphic $L_\infty$-algebras are obtained from a correspondence $L_\infty$-algebra by a homotopy transfer. Our construction is very useful: homotopy transfer is computationally tractable, and physically, it amounts to integrating out fields in a Feynman diagram expansion. Spans of $L_\infty$-algebras allow for a clean definition of quasi-isomorphisms of cyclic $L_\infty$-algebras. Furthermore, they appear naturally in many contexts within physics. As examples, we first consider scalar field theory with interaction vertices blown up in different ways. We then show that (non-Abelian) T-duality can be seen as a span of $L_\infty$-algebras, and we provide full details in the case of the principal chiral model. We also present the relevant span of $L_\infty$-algebras for the Penrose-Ward transform in the context of self-dual Yang-Mills theory and Bogomolny monopoles., Comment: 49 pages
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- 2023
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18. T-duality as Correspondences of Categorified Principal Bundles with Adjusted Connections
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Kim, Hyungrok and Saemann, Christian
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We provide a pedagogical introduction to the theory of principal 2-bundles with adjusted connections and show how they enter the description of geometric and non-geometric T-dualities as proposed in arXiv:2204.01783. This description combines the torus fibrations as well as the gerbe containing the Kalb-Ramond $B$-field into a single geometric object, a particular case of a non-abelian gerbe. The $B$-field and the metric are encoded in the connection of this categorified principal bundle, and a T-duality is described as a particular span or correspondence of such bundles. The formalism is manifestly covariant under the full T-duality group, and it readily reproduces key examples from the literature., Comment: 22 pages
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- 2023
19. Tree-Level Color-Kinematics Duality from Pure Spinor Actions
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Borsten, Leron, Jurco, Branislav, Kim, Hyungrok, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We prove that the tree-level scattering amplitudes for (super) Yang-Mills theory in arbitrary dimensions and for M2-brane models exhibit color-kinematics (CK) duality. Our proof for Yang-Mills theory substantially simplifies existing ones in that it relies on the action alone and does not involve any computation; the proof for M2-brane models establishes this result for the first time. Explicitly, we combine the facts that Chern-Simons-type theories naturally come with a kinematic Lie algebra and that both Yang-Mills theory and M2-brane models are of Chern-Simons form when formulated in pure spinor space, extending previous work on Yang-Mills currents arXiv:2108.11708. Our formulation also provides explicit kinematic Lie algebras for the theories under consideration in the form of diffeomorphisms on pure spinor space. The pure spinor formulation of CK-duality is based on ordinary, cubic vertices, but we explain how ordinary CK-duality relates to notions of quartic-vertex 3-Lie algebra CK-duality for M2-brane models previously discussed in the literature., Comment: 10 pages, expanded presentation, typos fixed, published version
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- 2023
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20. Colour-kinematics duality, double copy, and homotopy algebras
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Borsten, Leron, Kim, Hyungrok, Jurčo, Branislav, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory - Abstract
Colour-kinematics duality is a remarkable property of Yang-Mills theory. Its validity implies a relation between gauge theory and gravity scattering amplitudes, known as double copy. Albeit fully established at the tree level, its extension to the loop level is conjectural. Lifting the on-shell, scattering amplitudes-based description to the level of action functionals, we argue that a theory that exhibits tree-level colour-kinematics duality can be reformulated in a way such that its loop integrands manifest a generalised form of colour-kinematics duality. Moreover, we show how the structures of higher homotopy theory naturally describe this off-shell reformulation of colour-kinematics duality., Comment: 6 pages, proceedings of ICHEP 2022
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- 2022
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21. Kinematic Lie Algebras From Twistor Spaces
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Borsten, Leron, Jurco, Branislav, Kim, Hyungrok, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory - Abstract
We analyze theories with color-kinematics duality from an algebraic perspective and find that any such theory has an underlying BV${}^{\color{gray} \blacksquare}$-algebra structure, extending the ideas of arXiv:1912.03110. Conversely, we show that any theory with a BV${}^{\color{gray} \blacksquare}$-algebra features a kinematic Lie algebra that controls interaction vertices, both on- and off-shell. We explain that the archetypal example of a theory with BV${}^{\color{gray} \blacksquare}$-algebra is Chern-Simons theory, for which the resulting kinematic Lie algebra is isomorphic to the Schouten-Nijenhuis algebra on multivector fields. The BV${}^{\color{gray} \blacksquare}$-algebra implies the known color-kinematics duality of Chern-Simons theory. Similarly, we show that holomorphic and Cauchy-Riemann (CR) Chern-Simons theories come with BV${}^{\color{gray} \blacksquare}$-algebras and that, on the appropriate twistor spaces, these theories organize and identify kinematic Lie algebras for self-dual and full Yang-Mills theories, as well as the currents of any field theory with a twistorial description. We show that this result extends to the loop level under certain assumptions., Comment: v2: presentation improved, typos fixed, published version
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- 2022
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22. Improving Predictive Performance and Calibration by Weight Fusion in Semantic Segmentation
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Sämann, Timo, Hammam, Ahmed Mostafa, Bursuc, Andrei, Stiller, Christoph, and Groß, Horst-Michael
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Averaging predictions of a deep ensemble of networks is apopular and effective method to improve predictive performance andcalibration in various benchmarks and Kaggle competitions. However, theruntime and training cost of deep ensembles grow linearly with the size ofthe ensemble, making them unsuitable for many applications. Averagingensemble weights instead of predictions circumvents this disadvantageduring inference and is typically applied to intermediate checkpoints ofa model to reduce training cost. Albeit effective, only few works haveimproved the understanding and the performance of weight averaging.Here, we revisit this approach and show that a simple weight fusion (WF)strategy can lead to a significantly improved predictive performance andcalibration. We describe what prerequisites the weights must meet interms of weight space, functional space and loss. Furthermore, we presenta new test method (called oracle test) to measure the functional spacebetween weights. We demonstrate the versatility of our WF strategy acrossstate of the art segmentation CNNs and Transformers as well as real worlddatasets such as BDD100K and Cityscapes. We compare WF with similarapproaches and show our superiority for in- and out-of-distribution datain terms of predictive performance and calibration.
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- 2022
23. Cut-and-paste for impulsive gravitational waves with Λ: the mathematical analysis
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Sämann, Clemens, Schinnerl, Benedict, Steinbauer, Roland, and Švarc, Robert
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- 2024
- Full Text
- View/download PDF
24. Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures
- Author
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Belov, Vladimir, Erwin-Grabner, Tracy, Gonul, Ali Saffet, Amod, Alyssa R., Ojha, Amar, Aleman, Andre, Dols, Annemiek, Scharntee, Anouk, Uyar-Demir, Aslihan, Harrison, Ben J, Irungu, Benson M., Besteher, Bianca, Klimes-Dougan, Bonnie, Penninx, Brenda W. J. H., Mueller, Bryon A., Zarate, Carlos, Davey, Christopher G., Ching, Christopher R. K., Connolly, Colm G., Fu, Cynthia H. Y., Stein, Dan J., Dima, Danai, Linden, David E. J., Mehler, David M. A., Pomarol-Clotet, Edith, Pozzi, Elena, Melloni, Elisa, Benedetti, Francesco, MacMaster, Frank P., Grabe, Hans J., Völzke, Henry, Gotlib, Ian H., Soares, Jair C., Evans, Jennifer W., Sim, Kang, Wittfeld, Katharina, Cullen, Kathryn, Reneman, Liesbeth, Oudega, Mardien L., Wright, Margaret J., Portella, Maria J., Sacchet, Matthew D., Li, Meng, Aghajani, Moji, Wu, Mon-Ju, Jaworska, Natalia, Jahanshad, Neda, van der Wee, Nic J. A., Groenewold, Nynke, Hamilton, Paul J., Saemann, Philipp, Bülow, Robin, Poletti, Sara, Whittle, Sarah, Thomopoulos, Sophia I., van, Steven J. A., Werff, der, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Ho, Tiffany C., Yang, Tony T., Basgoze, Zeynep, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., and Goya-Maldonado, Roberto
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Quantitative Biology - Quantitative Methods - Abstract
Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with the largest multi-site sample size to date (n=5,356) to provide a generalizable ML classification benchmark of major depressive disorder (MDD). Using brain measures from standardized ENIGMA analysis pipelines in FreeSurfer, we were able to classify MDD vs healthy controls (HC) with around 62% balanced accuracy, but when harmonizing the data using ComBat balanced accuracy dropped to approximately 52%. Similar results were observed in stratified groups according to age of onset, antidepressant use, number of episodes and sex. Future studies incorporating higher dimensional brain imaging/phenotype features, and/or using more advanced machine and deep learning methods may achieve more encouraging prospects., Comment: main document 37 pages; supplementary material 24 pages
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- 2022
25. Hyperbolic angles in Lorentzian length spaces and timelike curvature bounds
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Beran, Tobias and Sämann, Clemens
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Mathematics - Differential Geometry ,General Relativity and Quantum Cosmology ,Mathematical Physics ,Mathematics - Metric Geometry ,28A75, 51K10, 53C23, 53C50, 53B30, 53C80, 83C99 - Abstract
Within the synthetic-geometric framework of Lorentzian (pre-)length spaces developed in Kunzinger and S\"amann (Ann. Glob. Anal. Geom. 54(3):399--447, 2018) we introduce a notion of a hyperbolic angle, an angle between timelike curves and related concepts like timelike tangent cone and exponential map. This provides valuable technical tools for the further development of the theory and paves the way for the main result of the article, which is the characterization of timelike curvature bounds (defined via triangle comparison) with an angle monotonicity condition. Further, we improve on a geodesic non-branching result for spaces with timelike curvature bounded below., Comment: 71 pages, 15 figures; v3: minor changes suggested by the referee
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- 2022
- Full Text
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26. Non-Geometric T-Duality as Higher Groupoid Bundles with Connections
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Kim, Hyungrok and Saemann, Christian
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We describe T-duality between general geometric and non-geometric backgrounds as higher groupoid bundles with connections. Our description extends the previous observation by Nikolaus and Waldorf that the topological aspects of geometric and half-geometric T-dualities can be described in terms of higher geometry. We extend their construction in two ways. First, we endow the higher geometries with adjusted connections, which allow us to discuss explicit formulas for the metric and the Kalb-Ramond field of a T-background. Second, we extend the principal 2-bundles to augmented 2-groupoid bundles, which accommodate the scalar fields arising in T-duality along several directions as well as $Q$- and $R$-fluxes. Our description is manifestly covariant under the full T-duality group $\mathsf{GO}(n,n;\mathbb{Z})$, and it has interesting physical and mathematical implications., Comment: 61 pages
- Published
- 2022
27. Assessing hypo-arousal during reward anticipation with pupillometry in patients with major depressive disorder: replication and correlations with anhedonia
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Andy Brendler, Max Schneider, Immanuel G. Elbau, Rui Sun, Taechawidd Nantawisarakul, Dorothee Pöhlchen, Tanja Brückl, BeCOME Working Group, Michael Czisch, Philipp G. Sämann, Michael D. Lee, and Victor I. Spoormaker
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Medicine ,Science - Abstract
Abstract Major depressive disorder (MDD) is a devastating and heterogenous disorder for which there are no approved biomarkers in clinical practice. We recently identified anticipatory hypo-arousal indexed by pupil responses as a candidate mechanism subserving depression symptomatology. Here, we conducted a replication and extension study of these findings. We analyzed a replication sample of 40 unmedicated patients with a diagnosis of depression and 30 healthy control participants, who performed a reward anticipation task while pupil responses were measured. Using a Bayesian modelling approach taking measurement uncertainty into account, we could show that the negative correlation between pupil dilation and symptom load during reward anticipation is replicable within MDD patients, albeit with a lower effect size. Furthermore, with the combined sample of 136 participants (81 unmedicated depressed and 55 healthy control participants), we further showed that reduced pupil dilation in anticipation of reward is inversely associated with anhedonia items of the Beck Depression Inventory in particular. Moreover, using simultaneous fMRI, particularly the right anterior insula as part of the salience network was negatively correlated with depressive symptom load in general and anhedonia items specifically. The present study supports the utility of pupillometry in assessing noradrenergically mediated hypo-arousal during reward anticipation in MDD, a physiological process that appears to subserve anhedonia.
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- 2024
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28. Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures
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Vladimir Belov, Tracy Erwin-Grabner, Moji Aghajani, Andre Aleman, Alyssa R. Amod, Zeynep Basgoze, Francesco Benedetti, Bianca Besteher, Robin Bülow, Christopher R. K. Ching, Colm G. Connolly, Kathryn Cullen, Christopher G. Davey, Danai Dima, Annemiek Dols, Jennifer W. Evans, Cynthia H. Y. Fu, Ali Saffet Gonul, Ian H. Gotlib, Hans J. Grabe, Nynke Groenewold, J Paul Hamilton, Ben J. Harrison, Tiffany C. Ho, Benson Mwangi, Natalia Jaworska, Neda Jahanshad, Bonnie Klimes-Dougan, Sheri-Michelle Koopowitz, Thomas Lancaster, Meng Li, David E. J. Linden, Frank P. MacMaster, David M. A. Mehler, Elisa Melloni, Bryon A. Mueller, Amar Ojha, Mardien L. Oudega, Brenda W. J. H. Penninx, Sara Poletti, Edith Pomarol-Clotet, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Matthew D. Sacchet, Philipp G. Sämann, Anouk Schrantee, Kang Sim, Jair C. Soares, Dan J. Stein, Sophia I. Thomopoulos, Aslihan Uyar-Demir, Nic J. A. van der Wee, Steven J. A. van der Werff, Henry Völzke, Sarah Whittle, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Tony T. Yang, Carlos Zarate, Dick J. Veltman, Lianne Schmaal, Paul M. Thompson, Roberto Goya-Maldonado, and the ENIGMA Major Depressive Disorder working group
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Medicine ,Science - Abstract
Abstract Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with the largest multi-site sample size to date (N = 5365) to provide a generalizable ML classification benchmark of major depressive disorder (MDD) using shallow linear and non-linear models. Leveraging brain measures from standardized ENIGMA analysis pipelines in FreeSurfer, we were able to classify MDD versus healthy controls (HC) with a balanced accuracy of around 62%. But after harmonizing the data, e.g., using ComBat, the balanced accuracy dropped to approximately 52%. Accuracy results close to random chance levels were also observed in stratified groups according to age of onset, antidepressant use, number of episodes and sex. Future studies incorporating higher dimensional brain imaging/phenotype features, and/or using more advanced machine and deep learning methods may yield more encouraging prospects.
- Published
- 2024
- Full Text
- View/download PDF
29. Explicit Non-Abelian Gerbes with Connections
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Rist, Dominik, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics ,Mathematics - Differential Geometry - Abstract
We define the notion of adjustment for strict Lie 2-groups and provide the complete cocycle description for non-Abelian gerbes with connections whose structure 2-group is an adjusted 2-group. Most importantly, we depart from the common fake-flat connections and employ adjusted connections. This is an important generalisation that is needed for physical applications especially in the context of supergravity. We give a number of explicit examples; in particular, we lift the spin structure on $S^4$, corresponding to an instanton-anti-instanton pair, to a string structure, a 2-group bundle with connection. We also outline how categorified forms of Bogomolny monopoles known as self-dual strings can be obtained via a Penrose-Ward transform of string bundles over twistor space., Comment: v3: 77 pages, presentation substantially changed, many results added
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- 2022
30. Neural correlates of transient topographical disorientation: an experimental EEG–MRI case study
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Zebhauser, Paul Theo, Vernet, Marine, Nischwitz, Sandra, Sämann, Philipp G., and Brem, Anna-Katharine
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- 2023
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31. A Lorentzian analog for Hausdorff dimension and measure
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McCann, Robert J. and Sämann, Clemens
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Mathematical Physics ,General Relativity and Quantum Cosmology ,Mathematics - Differential Geometry ,Mathematics - Metric Geometry ,28A75, 51K10, 53C23, 53C50, 53B30, 53C80, 83C99 - Abstract
We define a one-parameter family of canonical volume measures on Lorentzian (pre-)length spaces. In the Lorentzian setting, this allows us to define a geometric dimension - akin to the Hausdorff dimension for metric spaces - that distinguishes between e.g. spacelike and null subspaces of Minkowski spacetime. The volume measure corresponding to its geometric dimension gives a natural reference measure on a synthetic or limiting spacetime, and allows us to define what it means for such a spacetime to be collapsed (in analogy with metric measure geometry and the theory of Riemannian Ricci limit spaces). As a crucial tool we introduce a doubling condition for causal diamonds and a notion of causal doubling measures. Moreover, applications to continuous spacetimes and connections to synthetic timelike curvature bounds are given., Comment: 45 pages, 4 figures; v2: minor improvements
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- 2021
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32. Tree-Level Color-Kinematics Duality Implies Loop-Level Color-Kinematics Duality up to Counterterms
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Borsten, Leron, Jurco, Branislav, Kim, Hyungrok, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
Color-kinematics (CK) duality is a remarkable symmetry of gluon amplitudes that is the key to the double copy which links gauge theory and gravity amplitudes. Here we show that the complete Yang-Mills action itself, including its gauge-fixing and ghost sectors required for quantization, can be recast to manifest CK duality using a series of field redefinitions and gauge choices. Crucially, the resulting loop-level integrands are automatically CK-dual, up to potential Jacobian counterterms required for unitarity. While these counterterms may break CK duality, they exist, are unique and, since the tree-level is unaffected, may be deduced from the action or the integrands. Consequently, CK duality is a symmetry of the action like any other symmetry, and it is anomalous in a controlled and mostly harmless sense. Our results apply to any theory with CK-dual tree-level amplitudes. We also show that two CK duality-manifesting parent actions may be factorized and fused into a consistent quantizable offspring, with the double copy as the prime example. This provides a direct proof of the double copy to all loop orders., Comment: v3: 71 pages; arguments, statements, and presentation extended and improved; clarifications added; typos fixed; published version
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- 2021
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33. Stress-induced brain responses are associated with BMI in women
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Anne Kühnel, Jonas Hagenberg, Janine Knauer-Arloth, Maik Ködel, Michael Czisch, Philipp G. Sämann, BeCOME working group, Elisabeth B. Binder, and Nils B. Kroemer
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Biology (General) ,QH301-705.5 - Abstract
Abstract Overweight and obesity are associated with altered stress reactivity and increased inflammation. However, it is not known whether stress-induced changes in brain function scale with BMI and if such associations are driven by peripheral cytokines. Here, we investigate multimodal stress responses in a large transdiagnostic sample using predictive modeling based on spatio-temporal profiles of stress-induced changes in activation and functional connectivity. BMI is associated with increased brain responses as well as greater negative affect after stress and individual response profiles are associated with BMI in females (p perm
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- 2023
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34. Functional connectivity signatures of major depressive disorder: machine learning analysis of two multicenter neuroimaging studies
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Gallo, Selene, El-Gazzar, Ahmed, Zhutovsky, Paul, Thomas, Rajat M., Javaheripour, Nooshin, Li, Meng, Bartova, Lucie, Bathula, Deepti, Dannlowski, Udo, Davey, Christopher, Frodl, Thomas, Gotlib, Ian, Grimm, Simone, Grotegerd, Dominik, Hahn, Tim, Hamilton, Paul J., Harrison, Ben J., Jansen, Andreas, Kircher, Tilo, Meyer, Bernhard, Nenadić, Igor, Olbrich, Sebastian, Paul, Elisabeth, Pezawas, Lukas, Sacchet, Matthew D., Sämann, Philipp, Wagner, Gerd, Walter, Henrik, Walter, Martin, and van Wingen, Guido
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- 2023
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35. In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group
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Haukvik, Unn K, Gurholt, Tiril P, Nerland, Stener, Elvsåshagen, Torbjørn, Akudjedu, Theophilus N, Alda, Martin, Alnæs, Dag, Alonso‐Lana, Silvia, Bauer, Jochen, Baune, Bernhard T, Benedetti, Francesco, Berk, Michael, Bettella, Francesco, Bøen, Erlend, Bonnín, Caterina M, Brambilla, Paolo, Canales‐Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Dandash, Orwa, Dannlowski, Udo, Delvecchio, Giuseppe, Díaz‐Zuluaga, Ana M, Erp, Theo GM, Fatjó‐Vilas, Mar, Foley, Sonya F, Förster, Katharina, Fullerton, Janice M, Goikolea, José M, Grotegerd, Dominik, Gruber, Oliver, Haarman, Bartholomeus CM, Haatveit, Beathe, Hajek, Tomas, Hallahan, Brian, Harris, Mathew, Hawkins, Emma L, Howells, Fleur M, Hülsmann, Carina, Jahanshad, Neda, Jørgensen, Kjetil N, Kircher, Tilo, Krämer, Bernd, Krug, Axel, Kuplicki, Rayus, Lagerberg, Trine V, Lancaster, Thomas M, Lenroot, Rhoshel K, Lonning, Vera, López‐Jaramillo, Carlos, Malt, Ulrik F, McDonald, Colm, McIntosh, Andrew M, McPhilemy, Genevieve, Meer, Dennis, Melle, Ingrid, Melloni, Elisa MT, Mitchell, Philip B, Nabulsi, Leila, Nenadić, Igor, Oertel, Viola, Oldani, Lucio, Opel, Nils, Otaduy, Maria CG, Overs, Bronwyn J, Pineda‐Zapata, Julian A, Pomarol‐Clotet, Edith, Radua, Joaquim, Rauer, Lisa, Redlich, Ronny, Repple, Jonathan, Rive, Maria M, Roberts, Gloria, Ruhe, Henricus G, Salminen, Lauren E, Salvador, Raymond, Sarró, Salvador, Savitz, Jonathan, Schene, Aart H, Sim, Kang, Soeiro‐de‐Souza, Marcio G, Stäblein, Michael, Stein, Dan J, Stein, Frederike, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Veltman, Dick J, Vieta, Eduard, Waltemate, Lena, Westlye, Lars T, Whalley, Heather C, Sämann, Philipp G, Thompson, Paul M, Ching, Christopher RK, Andreassen, Ole A, Agartz, Ingrid, and Group, ENIGMA Bipolar Disorder Working
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Biological Psychology ,Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Psychology ,Brain Disorders ,Mental Health ,Serious Mental Illness ,Neurosciences ,Biomedical Imaging ,Bipolar Disorder ,Mental health ,Genetics ,Hippocampus ,Humans ,Magnetic Resonance Imaging ,Neuroimaging ,ENIGMA Bipolar Disorder Working Group ,bipolar disorder subtype ,hippocampus ,large-scale ,lithium ,psychosis ,structural brain MRI ,Cognitive Sciences ,Experimental Psychology ,Biological psychology ,Cognitive and computational psychology - Abstract
The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.
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- 2022
36. FreeSurfer‐based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts
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Sämann, Philipp G, Iglesias, Juan Eugenio, Gutman, Boris, Grotegerd, Dominik, Leenings, Ramona, Flint, Claas, Dannlowski, Udo, Clarke‐Rubright, Emily K, Morey, Rajendra A, Erp, Theo GM, Whelan, Christopher D, Han, Laura KM, Velzen, Laura S, Cao, Bo, Augustinack, Jean C, Thompson, Paul M, Jahanshad, Neda, and Schmaal, Lianne
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Mental Health ,Behavioral and Social Science ,Neurosciences ,Aging ,Brain Disorders ,Biomedical Imaging ,Neurodegenerative ,Bioengineering ,Neurological ,Mental health ,Hippocampus ,Humans ,Image Processing ,Computer-Assisted ,Magnetic Resonance Imaging ,Multicenter Studies as Topic ,Neuroimaging ,Quality Control ,ENIGMA ,FreeSurfer ,MRI ,hippocampal subfields ,hippocampal subregions ,hippocampus ,quality control ,segmentation ,Cognitive Sciences ,Experimental Psychology ,Biological psychology ,Cognitive and computational psychology - Abstract
Structural hippocampal abnormalities are common in many neurological and psychiatric disorders, and variation in hippocampal measures is related to cognitive performance and other complex phenotypes such as stress sensitivity. Hippocampal subregions are increasingly studied, as automated algorithms have become available for mapping and volume quantification. In the context of the Enhancing Neuro Imaging Genetics through Meta Analysis Consortium, several Disease Working Groups are using the FreeSurfer software to analyze hippocampal subregion (subfield) volumes in patients with neurological and psychiatric conditions along with data from matched controls. In this overview, we explain the algorithm's principles, summarize measurement reliability studies, and demonstrate two additional aspects (subfield autocorrelation and volume/reliability correlation) with illustrative data. We then explain the rationale for a standardized hippocampal subfield segmentation quality control (QC) procedure for improved pipeline harmonization. To guide researchers to make optimal use of the algorithm, we discuss how global size and age effects can be modeled, how QC steps can be incorporated and how subfields may be aggregated into composite volumes. This discussion is based on a synopsis of 162 published neuroimaging studies (01/2013-12/2019) that applied the FreeSurfer hippocampal subfield segmentation in a broad range of domains including cognition and healthy aging, brain development and neurodegeneration, affective disorders, psychosis, stress regulation, neurotoxicity, epilepsy, inflammatory disease, childhood adversity and posttraumatic stress disorder, and candidate and whole genome (epi-)genetics. Finally, we highlight points where FreeSurfer-based hippocampal subfield studies may be optimized.
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- 2022
37. $EL_\infty$-algebras, Generalized Geometry, and Tensor Hierarchies
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Borsten, Leron, Kim, Hyungrok, and Saemann, Christian
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We define a generalized form of $L_\infty$-algebras called $EL_\infty$-algebras. As we show, these provide the natural algebraic framework for generalized geometry and the symmetries of double field theory as well as the gauge algebras arising in the tensor hierarchies of gauged supergravity. Our perspective shows that the kinematical data of the tensor hierarchy is an adjusted higher gauge theory, which is important for developing finite gauge transformations as well as non-local descriptions. Mathematically, $EL_\infty$-algebras provide small resolutions of the operad $\mathcal{L}ie$, and they shed some light on Loday's problem of integrating Leibniz algebras., Comment: 65 pages
- Published
- 2021
38. Inspect, Understand, Overcome: A Survey of Practical Methods for AI Safety
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Houben, Sebastian, Abrecht, Stephanie, Akila, Maram, Bär, Andreas, Brockherde, Felix, Feifel, Patrick, Fingscheidt, Tim, Gannamaneni, Sujan Sai, Ghobadi, Seyed Eghbal, Hammam, Ahmed, Haselhoff, Anselm, Hauser, Felix, Heinzemann, Christian, Hoffmann, Marco, Kapoor, Nikhil, Kappel, Falk, Klingner, Marvin, Kronenberger, Jan, Küppers, Fabian, Löhdefink, Jonas, Mlynarski, Michael, Mock, Michael, Mualla, Firas, Pavlitskaya, Svetlana, Poretschkin, Maximilian, Pohl, Alexander, Ravi-Kumar, Varun, Rosenzweig, Julia, Rottmann, Matthias, Rüping, Stefan, Sämann, Timo, Schneider, Jan David, Schulz, Elena, Schwalbe, Gesina, Sicking, Joachim, Srivastava, Toshika, Varghese, Serin, Weber, Michael, Wirkert, Sebastian, Wirtz, Tim, and Woehrle, Matthias
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Computer Science - Machine Learning ,Computer Science - Computers and Society - Abstract
The use of deep neural networks (DNNs) in safety-critical applications like mobile health and autonomous driving is challenging due to numerous model-inherent shortcomings. These shortcomings are diverse and range from a lack of generalization over insufficient interpretability to problems with malicious inputs. Cyber-physical systems employing DNNs are therefore likely to suffer from safety concerns. In recent years, a zoo of state-of-the-art techniques aiming to address these safety concerns has emerged. This work provides a structured and broad overview of them. We first identify categories of insufficiencies to then describe research activities aiming at their detection, quantification, or mitigation. Our paper addresses both machine learning experts and safety engineers: The former ones might profit from the broad range of machine learning topics covered and discussions on limitations of recent methods. The latter ones might gain insights into the specifics of modern ML methods. We moreover hope that our contribution fuels discussions on desiderata for ML systems and strategies on how to propel existing approaches accordingly., Comment: 94 pages
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- 2021
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39. Double Copy from Homotopy Algebras
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Borsten, Leron, Jurco, Branislav, Kim, Hyungrok, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We show that the BRST Lagrangian double copy construction of $\mathcal{N}=0$ supergravity as the `square' of Yang-Mills theory finds a natural interpretation in terms of homotopy algebras. We significantly expand on our previous work arguing the validity of the double copy at the loop level, and we give a detailed derivation of the double copied Lagrangian and BRST operator. Our constructions are very general and can be applied to a vast set of examples., Comment: v2: 168 pages, presentation improved, typos fixed, published version
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- 2021
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40. 'You should brush your teeth better': a randomized controlled trial comparing best-possible versus as-usual toothbrushing
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Ulrike Weik, Sadhvi Shankar-Subramanian, Thorben Sämann, Bernd Wöstmann, Jutta Margraf-Stiksrud, and Renate Deinzer
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Oral hygiene ,Tooth brushing ,Dental plaque ,Dental health surveys ,Health education ,Health behavior ,Dentistry ,RK1-715 - Abstract
Abstract Background Most people’s tooth brushing performance is deficient, even when they are encouraged to brush to the best of their abilities. The aim of the present study was to explore the nature of this deficit by comparing best-possible vs. as-usual brushing. Methods University students (N = 111) were randomly assigned to receive one of two instructions: “brush your teeth as usual” (AU-instruction) or “brush your teeth to the best of your abilities” (BP-instruction). Video analyses assessed brushing performance. The marginal plaque index (MPI) assessed after brushing was used as an indicator of brushing effectiveness. A questionnaire assessed subjectively perceived oral cleanliness (SPOC). Results Participants in the BP group brushed their teeth longer (p = 0.008, d = 0.57) and used interdental devices more often (p 0.16, all d
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- 2023
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41. Towards an M5-Brane Model III: Self-Duality from Additional Trivial Fields
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Rist, Dominik, Saemann, Christian, and van der Worp, Miro
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We present a six-dimensional $\mathcal{N}=(1,0)$ supersymmetric higher gauge theory in which self-duality is consistently implemented by physically trivial additional fields. The action contains both $\mathcal{N}=(1,0)$ tensor and vector multiplets and is non-trivially interacting. The tensor multiplet part is loosely related to a recently proposed action by Sen that leads to on-shell self-duality in an elegant way. As we also show, Sen's action finds a very natural and direct interpretation from a homotopy algebraic perspective., Comment: 29 pages, typos fixed, clarifications added, published version
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- 2020
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42. Conceptual Design of BabyIAXO, the intermediate stage towards the International Axion Observatory
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Abeln, A., Altenmüller, K., Cuendis, S. Arguedas, Armengaud, E., Attié, D., Aune, S., Basso, S., Bergé, L., Biasuzzi, B., De Sousa, P. T. C. Borges, Brun, P., Bykovskiy, N., Calvet, D., Carmona, J. M., Castel, J. F., Cebrián, S., Chernov, V., Christensen, F. E., Civitani, M. M., Cogollos, C., Dafní, T., Derbin, A., Desch, K., Díez, D., Dinter, M., Döbrich, B., Drachnev, I., Dudarev, A., Dumoulin, L., Ferreira, D. D. M., Ferrer-Ribas, E., Fleck, I., Galán, J., Gascón, D., Gastaldo, L., Giannotti, M., Giomataris, Y., Giuliani, A., Gninenko, S., Golm, J., Golubev, N., Hagge, L., Hahn, J., Hailey, C. J., Hengstler, D., Henriksen, P. L., Houdy, T., Iglesias-Marzoa, R., Iguaz, F. J., Irastorza, I. G., Iñiguez, C., Jakovcic, K., Kaminski, J., Kanoute, B., Karstensen, S., Kravchuk, L., Lakic, B., Lasserre, T., Laurent, P., Limousin, O., Lindner, A., Loidl, M., Lomskaya, I., López-Alegre, G., Lubsandorzhiev, B., Ludwig, K., Luzón, G., Malbrunot, C., Margalejo, C., Marin-Franch, A., Marnieros, S., Marutzky, F., Mauricio, J., Menesguen, Y., Mentink, M., Mertens, S., Mescia, F., Miralda-Escudé, J., Mirallas, H., Mols, J. P., Muratova, V., Navick, X. F., Nones, C., Notari, A., Nozik, A., Obis, L., Oriol, C., Orsini, F., de Solórzano, A. Ortiz, Oster, S., Da Silva, H. P. Pais, Pantuev, V., Papaevangelou, T., Pareschi, G., Perez, K., Pérez, O., Picatoste, E., Pivovaroff, M. J., Poda, D. V., Redondo, J., Ringwald, A., Rodrigues, M., Rueda-Teruel, F., Rueda-Teruel, S., Ruiz-Choliz, E., Ruz, J., Saemann, E. O., Salvado, J., Schiffer, T., Schmidt, S., Schneekloth, U., Schott, M., Segui, L., Tavecchio, F., Kate, H. H. J. ten, Tkachev, I., Troitsky, S., Unger, D., Unzhakov, E., Ushakov, N., Vogel, J. K., Voronin, D., Weltman, A., Werthenbach, U., Wuensch, W., and Yanes-Díaz, A.
- Subjects
Physics - Instrumentation and Detectors ,Astrophysics - Instrumentation and Methods for Astrophysics ,High Energy Physics - Experiment - Abstract
This article describes BabyIAXO, an intermediate experimental stage of the International Axion Observatory (IAXO), proposed to be sited at DESY. IAXO is a large-scale axion helioscope that will look for axions and axion-like particles (ALPs), produced in the Sun, with unprecedented sensitivity. BabyIAXO is conceived to test all IAXO subsystems (magnet, optics and detectors) at a relevant scale for the final system and thus serve as prototype for IAXO, but at the same time as a fully-fledged helioscope with relevant physics reach itself, and with potential for discovery. The BabyIAXO magnet will feature two 10 m long, 70 cm diameter bores, and will host two detection lines (optics and detector) of dimensions similar to the final ones foreseen for IAXO. BabyIAXO will detect or reject solar axions or ALPs with axion-photon couplings down to $g_{a\gamma} \sim 1.5 \times 10^{-11}$ GeV$^{-1}$, and masses up to $m_a\sim 0.25$ eV. BabyIAXO will offer additional opportunities for axion research in view of IAXO, like the development of precision x-ray detectors to identify particular spectral features in the solar axion spectrum, and the implementation of radiofrequency-cavity-based axion dark matter setups., Comment: 77 pages, 49 figures. Prepared for submission to JHEP. Third version after referees comments
- Published
- 2020
43. Symmetry Factors of Feynman Diagrams and the Homological Perturbation Lemma
- Author
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Saemann, Christian and Sfinarolakis, Emmanouil
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We discuss the symmetry factors of Feynman diagrams of scalar field theories with polynomial potential. After giving a concise general formula for them, we present an elementary and direct proof that when computing scattering amplitudes using the homological perturbation lemma, each contributing Feynman diagram is indeed included with the correct symmetry factor., Comment: 20 pages
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- 2020
- Full Text
- View/download PDF
44. Lorentz meets Lipschitz
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Lange, Christian, Lytchak, Alexander, and Sämann, Clemens
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Mathematics - Differential Geometry ,General Relativity and Quantum Cosmology ,Mathematical Physics ,Mathematics - Classical Analysis and ODEs ,53B30, 34A36, 83C99 - Abstract
We show that maximal causal curves for a Lipschitz continuous Lorentzian metric admit a $\mathcal{C}^{1,1}$-parametrization and that they solve the geodesic equation in the sense of Filippov in this parametrization. Our proof shows that maximal causal curves are either everywhere lightlike or everywhere timelike. Furthermore, the proof demonstrates that maximal causal curves for an $\alpha$-H\"older continuous Lorentzian metric admit a $\mathcal{C}^{1,\frac{\alpha}{4}}$-parametrization., Comment: 25 pages; v2: minor improvements of the presentation
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- 2020
- Full Text
- View/download PDF
45. BRST-Lagrangian Double Copy of Yang-Mills Theory
- Author
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Borsten, Leron, Jurco, Branislav, Kim, Hyungrok, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory - Abstract
We show that the double copy of gauge theory amplitudes to $\mathcal{N}=0$ supergravity amplitudes extends from tree level to loop level. We first explain that color-kinematic duality is a condition for the Becchi-Rouet-Stora-Tyutin operator and the action of a field theory with cubic interaction terms to double copy to a consistent gauge theory. We then apply this argument to Yang-Mills theory, where color-kinematic duality is known to be satisfied onshell at tree level. Finally, we show that the latter restriction can only lead to terms that can be absorbed in a sequence of field redefinitions, rendering the double copied action equivalent to $\mathcal{N}=0$ supergravity., Comment: v2: 7 pages, improved presentation, published version
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- 2020
- Full Text
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46. Perturbative Quantum Field Theory and Homotopy Algebras
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Jurco, Branislav, Kim, Hyungrok, Macrelli, Tommaso, Saemann, Christian, and Wolf, Martin
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High Energy Physics - Theory ,Mathematical Physics - Abstract
We review the homotopy algebraic perspective on perturbative quantum field theory: classical field theories correspond to homotopy algebras such as $A_\infty$- and $L_\infty$-algebras. Furthermore, their scattering amplitudes are encoded in minimal models of these homotopy algebras at tree level and their quantum relatives at loop level. The translation between Lagrangian field theories and homotopy algebras is provided by the Batalin--Vilkovisky formalism. The minimal models are computed recursively using the homological perturbation lemma, which induces useful recursion relations for the computation of scattering amplitudes. After explaining how the homological perturbation lemma produces the usual Feynman diagram expansion, we use our techniques to verify an identity for the Berends--Giele currents which implies the Kleiss--Kuijf relations., Comment: v2: 25 pages, contribution to the proceedings of the Corfu Summer Institute 2019 "School and Workshops on Elementary Particle Physics and Gravity", typos fixed, published version
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- 2020
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47. Strategy to Increase the Safety of a DNN-based Perception for HAD Systems
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Sämann, Timo, Schlicht, Peter, and Hüger, Fabian
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Safety is one of the most important development goals for highly automated driving (HAD) systems. This applies in particular to the perception function driven by Deep Neural Networks (DNNs). For these, large parts of the traditional safety processes and requirements are not fully applicable or sufficient. The aim of this paper is to present a framework for the description and mitigation of DNN insufficiencies and the derivation of relevant safety mechanisms to increase the safety of DNNs. To assess the effectiveness of these safety mechanisms, we present a categorization scheme for evaluation metrics.
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- 2020
48. Stress-induced brain responses are associated with BMI in women
- Author
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Kühnel, Anne, Hagenberg, Jonas, Knauer-Arloth, Janine, Ködel, Maik, Czisch, Michael, Sämann, Philipp G., Binder, Elisabeth B., and Kroemer, Nils B.
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- 2023
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49. “You should brush your teeth better”: a randomized controlled trial comparing best-possible versus as-usual toothbrushing
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Weik, Ulrike, Shankar-Subramanian, Sadhvi, Sämann, Thorben, Wöstmann, Bernd, Margraf-Stiksrud, Jutta, and Deinzer, Renate
- Published
- 2023
- Full Text
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50. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
- Author
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Han, Laura KM, Dinga, Richard, Hahn, Tim, Ching, Christopher RK, Eyler, Lisa T, Aftanas, Lyubomir, Aghajani, Moji, Aleman, André, Baune, Bernhard T, Berger, Klaus, Brak, Ivan, Filho, Geraldo Busatto, Carballedo, Angela, Connolly, Colm G, Couvy-Duchesne, Baptiste, Cullen, Kathryn R, Dannlowski, Udo, Davey, Christopher G, Dima, Danai, Duran, Fabio LS, Enneking, Verena, Filimonova, Elena, Frenzel, Stefan, Frodl, Thomas, Fu, Cynthia HY, Godlewska, Beata R, Gotlib, Ian H, Grabe, Hans J, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Hall, Geoffrey B, Harrison, Ben J, Hatton, Sean N, Hermesdorf, Marco, Hickie, Ian B, Ho, Tiffany C, Hosten, Norbert, Jansen, Andreas, Kähler, Claas, Kircher, Tilo, Klimes-Dougan, Bonnie, Krämer, Bernd, Krug, Axel, Lagopoulos, Jim, Leenings, Ramona, MacMaster, Frank P, MacQueen, Glenda, McIntosh, Andrew, McLellan, Quinn, McMahon, Katie L, Medland, Sarah E, Mueller, Bryon A, Mwangi, Benson, Osipov, Evgeny, Portella, Maria J, Pozzi, Elena, Reneman, Liesbeth, Repple, Jonathan, Rosa, Pedro GP, Sacchet, Matthew D, Sämann, Philipp G, Schnell, Knut, Schrantee, Anouk, Simulionyte, Egle, Soares, Jair C, Sommer, Jens, Stein, Dan J, Steinsträter, Olaf, Strike, Lachlan T, Thomopoulos, Sophia I, van Tol, Marie-José, Veer, Ilya M, Vermeiren, Robert RJM, Walter, Henrik, van der Wee, Nic JA, van der Werff, Steven JA, Whalley, Heather, Winter, Nils R, Wittfeld, Katharina, Wright, Margaret J, Wu, Mon-Ju, Völzke, Henry, Yang, Tony T, Zannias, Vasileios, de Zubicaray, Greig I, Zunta-Soares, Giovana B, Abé, Christoph, Alda, Martin, Andreassen, Ole A, Bøen, Erlend, Bonnin, Caterina M, Canales-Rodriguez, Erick J, Cannon, Dara, Caseras, Xavier, Chaim-Avancini, Tiffany M, Elvsåshagen, Torbjørn, Favre, Pauline, Foley, Sonya F, and Fullerton, Janice M
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Depression ,Aging ,Brain Disorders ,Biomedical Imaging ,Serious Mental Illness ,Mental Health ,Major Depressive Disorder ,Behavioral and Social Science ,Clinical Research ,Neurosciences ,2.3 Psychological ,social and economic factors ,Aetiology ,Mental health ,Adolescent ,Adult ,Aged ,Brain ,Depressive Disorder ,Major ,Female ,Humans ,Longitudinal Studies ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Young Adult ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.
- Published
- 2021
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