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1. General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

Author

Steffen, Annika, Huerta, José-Maria, Weiderpass, Elisabete, Bueno-de-Mesquita, HB As, May, Anne M, Siersema, Peter D, Kaaks, Rudolf, Neamat-Allah, Jasmine, Pala, Valeria, Panico, Salvatore, Saieva, Calogero, Tumino, Rosario, Naccarati, Alessio, Dorronsoro, Miren, Sánchez-Cantalejo, Emilio, Ardanaz, Eva, Quirós, J Ramón, Ohlsson, Bodil, Johansson, Mattias, Wallner, Bengt, Overvad, Kim, Halkjaer, Jytte, Tjønneland, Anne, Fagherazzi, Guy, Racine, Antoine, Clavel-Chapelon, Françoise, Key, Tim J, Khaw, Kay-Tee, Wareham, Nick, Lagiou, Pagona, Bamia, Christina, Trichopoulou, Antonia, Ferrari, Pietro, Freisling, Heinz, Lu, Yunxia, Riboli, Elio, Cross, Amanda J, Gonzalez, Carlos A, and Boeing, Heiner

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Prevention, Rare Diseases, Digestive Diseases, Cancer, Obesity, Nutrition, Adenocarcinoma, Adult, Aged, Body Mass Index, Body Weights and Measures, Esophageal Neoplasms, Europe, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Abdominal, Population Surveillance, Prospective Studies, Risk, Risk Factors, Stomach Neoplasms, abdominal obesity, body mass index, esophageal cancer, gastric cancer, general obesity, waist circumference, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data from 391,456 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) study and 11 years of follow-up, we comprehensively assessed the association of anthropometric measures with risk of EAC, GCC and GNCC using multivariable proportional hazards regression. One hundred twenty-four incident EAC, 193 GCC and 224 GNCC were accrued. After mutual adjustment, BMI was unrelated to EAC, while WC showed a strong positive association (highest vs. lowest quintile HR = 1.19; 95% CI, 0.63-2.22 and HR = 3.76; 1.72-8.22, respectively). Hip circumference (HC) was inversely related to EAC after controlling for WC, while WC remained positively associated (HR = 0.35; 0.18-0.68, and HR=4.10; 1.94-8.63, respectively). BMI was not associated with GCC or GNCC. WC was related to higher risks of GCC after adjustment for BMI and more strongly after adjustment for HC (highest vs. lowest quintile HR = 1.91; 1.09-3.37, and HR = 2.23; 1.28-3.90, respectively). Our study demonstrates that abdominal, rather than general, obesity is an indisputable risk factor for EAC and also provides evidence for a protective effect of gluteofemoral (subcutaneous) adipose tissue in EAC. Our study further shows that general obesity is not a risk factor for GCC and GNCC, while the role of abdominal obesity in GCC needs further investigation.

Published
2015

3. Plasma levels of OPN (ng/ml) in HCC Cases and matched Controls. from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Author

Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary

Published
2023
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4. Data from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Author

Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary

Published
2023
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5. Supplementary Figures Legends from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Author

Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary

Published
2023
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6. Cubic spline for the association between OPN levels and HCC from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Author

Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary

Published
2023
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7. Supplementary Tables from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Author

Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary

Published
2023
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8. An epidemiological model for prediction of endometrial cancer risk in Europe

Author

Hüsing, Anika, Dossus, Laure, Ferrari, Pietro, Tjønneland, Anne, Hansen, Louise, Fagherazzi, Guy, Baglietto, Laura, Schock, Helena, Chang-Claude, Jenny, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Bamia, Christina, Katsoulis, Michalis, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Onland-Moret, N. Charlotte, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Weiderpass, Elisabete, Gram, Inger T., Ardanaz, Eva, Obón-Santacana, Mireia, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Etxezarreta, Nerea, Allen, Naomi E., Khaw, Kay Tee, Wareham, Nick, Rinaldi, Sabina, Romieu, Isabelle, Merritt, Melissa A., Gunter, Marc, Riboli, Elio, and Kaaks, Rudolf

Published
2016

12. Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Lujan-Barroso, Leila, González, Carlos Alberto, Slimani, Nadia, Obón-Santacana, Mireia, Ferrari, Pietro, Freisling, Heinz, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Racine, Antoine, Katzke, Verena, Kühn, Tilman, Tjønneland, Anne, Olsen, Anja, Quirós, J. Ramón, Sánchez-Cantalejo, Emilio, Amiano, Pilar, Navarro, Carmen, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Trichopoulou, Antonia, Bamia, Christina, Benetou, Vassiliki, Saieva, Calogero, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Mattiello, Amalia, Bueno-de-Mesquita, H. Bas, Siersema, Peter D., Numans, Mattijs E., Peeters, Petra H., Ericson, Ulrika, Wirfält, Elisabet, Sund, Malin, Johansson, Mattias, Weiderpass, Elisabete, Skeie, Guri, Riboli, Elio, Boeing, Heiner, and Duell, Eric J.

Published
2014

14. Hepcidin levels and gastric cancer risk in the EPIC-EurGast study

Author

Jakszyn, Paula, Fonseca-Nunes, Ana, Lujan-Barroso, Leila, Aranda, Núria, Tous, Mónica, Arija, Victoria, Cross, Amanda, Bueno-de-Mesquita, B(as) H., Weiderpass, Elisabete, Kühn, Tilman, Kaaks, Rudolf, Sjöberg, Klas, Ohlsson, Bodil, Tumino, Rosario, Palli, Domenico, Ricceri, Fulvio, Fasanelli, Francesca, Krogh, Vittorio, Mattiello, Amalia, Jenab, Mazda, Gunter, Marc, Perez-Cornago, Aurora, Khaw, Kay-Tee, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Trichopoulou, Antonia, Peppa, Eleni, Vasilopoulou, Effie, Boeing, Heiner, Sánchez-Cantalejo, Emilio, Huerta, José María, Dorronsoro, Miren, Barricarte, Aurelio, Quirós, José Maria, Peeters, Petra H., and Agudo, Antonio

Published
2017
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15. Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Agudo, Antonio, Luján-Barroso, Leila, Romieu, Isabelle, Ferrari, Pietro, Knaze, Viktoria, Bueno-de-Mesquita, H Bas, Leenders, Max, Travis, Ruth C, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Slimani, Nadia, Scalbert, Augustin, Fedirko, Veronika, Hjartåker, Anette, Engeset, Dagrun, Skeie, Guri, Boeing, Heiner, Förster, Jana, Li, Kuanrong, Teucher, Birgit, Agnoli, Claudia, Tumino, Rosario, Mattiello, Amalia, Saieva, Calogero, Johansson, Ingegerd, Stenling, Roger, Redondo, Maria Luisa, Wallström, Peter, Ericson, Ulrika, Khaw, Kay-Tee, Mulligan, Angela A, Trichopoulou, Antonia, Dilis, Vardis, Katsoulis, Michael, Peeters, Petra HM, Igali, Lazslo, Tjønneland, Anne, Halkjær, Jytte, Touillaud, Marina, Perquier, Florence, Fagherazzi, Guy, Amiano, Pilar, Ardanaz, Eva, Bredsdorff, Lea, Overvad, Kim, Ricceri, Fulvio, Riboli, Elio, and González, Carlos A

Published
2012
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17. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E, Key, Timothy J, Bueno-de-Mesquita, H Bas, Ros, Martine M, Numans, Mattijs E, Peeters, Petra HM, Trichopoulou, Antonia, Naska, Androniki, Dilis, Vardis, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Regner, Sara, Lindkvist, Björn, Johansson, Ingegerd, Hallmans, Göran, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Lund, Eiliv, Weiderpass, Elisabete, Braaten, Tonje, Romieu, Isabelle, Ferrari, Pietro, Jenab, Mazda, Stenling, Roger, Aune, Dagfinn, Norat, Teresa, Riboli, Elio, and González, Carlos A

Published
2011
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18. Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Author

Chajès, Véronique, Jenab, Mazda, Romieu, Isabelle, Ferrari, Pietro, Dahm, Christina C, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Engel, Pierre, Teucher, Birgit, Kaaks, Rudolf, Floegel, Anna, Boeing, Heiner, Trichopoulou, Antonia, Dilis, Vardis, Karapetyan, Tina, Mattiello, Amalia, Tumino, Rosario, Grioni, Sara, Palli, Domenico, Vineis, Paolo, Bueno-de-Mesquita, H Bas, Numans, Mattijs E, Peeters, Petra HM, Lund, Eiliv, Navarro, Carmen, Quirós, Jose Ramón, Sánchez-Cantalejo, Emilio, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Regnér, Sara, Sonestedt, Emily, Wirfält, Elisabet, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Crowe, Francesca L, Rinaldi, Sabina, Slimani, Nadia, Carneiro, Fatima, Riboli, Elio, and González, Carlos A

Published
2011
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19. Lifestyle factors and mortality risk in individuals with diabetes mellitus: are the associations different from those in individuals without diabetes?

Author

Sluik, Diewertje, Boeing, Heiner, Li, Kuanrong, Kaaks, Rudolf, Johnsen, Nina Føns, Tjønneland, Anne, Arriola, Larraitz, Barricarte, Aurelio, Masala, Giovanna, Grioni, Sara, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Spijkerman, Annemieke M. W., van der A, Daphne L., Sluijs, Ivonne, Franks, Paul W., Nilsson, Peter M., Orho-Melander, Marju, Fhärm, Eva, Rolandsson, Olov, Riboli, Elio, Romaguera, Dora, Weiderpass, Elisabete, Sánchez-Cantalejo, Emilio, and Nöthlings, Ute

Published
2014
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20. Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: Results from the EPIC cohort study

Author

Sanikini, Harinakshi, Dik, Vincent K., Siersema, Peter D., Bhoo-Pathy, Nirmala, Uiterwaal, Cuno S.P.M., Peeters, Petra H.M., González, Carlos A., Zamora-Ros, Raul, Overvad, Kim, Tjønneland, Anne, Roswall, Nina, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Kühn, Tilman, Katzke, Verena, Boeing, Heiner, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Lagiou, Pagona, Palli, Domenico, Grioni, Sara, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Weiderpass, Elisabete, Skeie, Guri, Braaten, Tonje, Huerta, José María, Sánchez-Cantalejo, Emilio, Barricarte, Aurelio, Sonestedt, Emily, Wallstrom, Peter, Nilsson, Lena Maria, Johansson, Ingegerd, Bradbury, Kathryn E, Khaw, Kay-Tee, Wareham, Nick, Huybrechts, Inge, Freisling, Heinz, Cross, Amanda J., Riboli, Elio, and Bueno-de-Mesquita, H. B(as)

Published
2015
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21. Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population

Author

Duell, Eric J., Bonet, Catalina, Muñoz, Xavier, Lujan-Barroso, Leila, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Racine, Antoine, Severi, Gianluca, Canzian, Federico, Rizzato, Cosmeri, Boeing, Heiner, Overvad, Kim, Tjnneland, Anne, Argüelles, Marcial, Sánchez-Cantalejo, Emilio, Chamosa, Saioa, Huerta, José María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Rutch C., Trichopoulou, Antonia, Trichopoulos, Dimitrios, Yiannakouris, Nikos, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Bueno-de-Mesquita, B(as) H, Siersema, Peter D., Peeters, Petra H.M., Ohlsson, Bodil, Lindkvist, Björn, Johansson, Ingegerd, Ye, Weimin, Johansson, Matthias, Fenger, Claus, Riboli, Elio, Sala, Núria, and González, Carlos A.

Published
2015
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22. Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: Results from the EPIC-EURGAST study

Author

Espinosa-Parrilla, Yolanda, Muñoz, Xavier, Bonet, Catalina, Garcia, Nadia, Venceslá, Adoración, Yiannakouris, Nikos, Naccarati, Alessio, Sieri, Sabina, Panico, Salvatore, Huerta, José M., Barricarte, Aurelio, Menéndez, Virginia, Sánchez-Cantalejo, Emilio, Dorronsoro, Miren, Brennan, Paul, Duarte-Salles, Talita, Bueno-de-Mesquita, B(as) H., Weiderpass, Elisabete, Lund, Eiliv, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Racine, Antoine, Numans, Mattijs E., Tumino, Rosario, Canzian, Federico, Campa, Daniele, Sund, Malin, Johansson, Mattias, Ohlsson, Bodil, Lindkvist, Björn, Overvad, Kim, Tjnneland, Anne, Palli, Domenico, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nick, Boeing, Heiner, Nesi, Gabriella, Riboli, Elio, Gonzalez, Carlos A., and Sala, Núria

Published
2014
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25. Aromatic adducts and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort

Author

Gilberson, Tamra, Peluso, Marco E.M., Munia, Armelle, Luján-Barroso, Leila, Sánchez, María-José, Navarro, Carmen, Amiano, Pilar, Barricarte, Aurelio, Quirós, Ramón J., Molina-Montes, Esther, Sánchez-Cantalejo, Emilio, Tormo, María-José, Chirlaque, María-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Confortini, Massimo, Bonet, Catalina, Sala, Núria, González, Carlos A., and Agudo, Antonio

Published
2014
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27. Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer-eurgast cohort

Author

Companioni, Osmel, Bonet, Catalina, Muñoz, Xavier, Weiderpass, Elisabete, Panico, Salvatore, Tumino, Rosario, Palli, Domenico, Agnoli, Claudia, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Clavel-Chapelon, Françoise, Travis, Ruth C., Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Benetou, Vassiliki, Trichopoulos, Dimitrios, Lund, Eiliv, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Sund, Malin, Ardanaz, Eva, Sánchez-Cantalejo, Emilio, Huerta, Jose M., Dorronsoro, Miren, Quirós, José Ramón, Tjonneland, Anne, Mortensen, Lotte Maxild, Overvad, Kim, Chang-Claude, Jenny, Rizzato, Cosmeri, Boeing, Heiner, de Mesquita, Bas H. Bueno, Siersema, Peter, Peeters, Petra H.M., Numans, Mattijs E., Carneiro, Fatima, Licaj, Idlir, Freisling, Heinz, Sala, Núria, and González, Carlos A.

Published
2014
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29. Fruit and vegetable intake and the risk of gastric adenocarcinoma: A reanalysis of the european prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up

Author

Gonzalez, Carlos A., Lujan-Barroso, Leila, Bueno-de-Mesquita, H. B(as)., Jenab, Mazda, Duell, Eric J., Agudo, Antonio, Tjnneland, Anne, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Touillaud, Marina, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Roukos, Dimitrios, Karapetyan, Tina, Palli, Domenico, Tagliabue, Giovanna, Mattiello, Amalia, Tumino, Rosario, Ricceri, Fulvio, Siersema, Peter D., Numans, Mattijs E., Peeters, Petra P.H., Parr, Christine L., Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Ehrnström, Roy, Regner, Sara, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Crowe, Francesca L., Blaker, Hendrik, Romieu, Isabelle, and Riboli, Elio

Published
2012
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30. Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Duell, Eric J., Sala, Núria, Travier, Noémie, Muñoz, Xavier, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Barricarte, Aurelio, Arriola, Larraitz, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Quirós, J.Ramón, Krogh, Vittorio, Vineis, Paolo, Mattiello, Amalia, Tumino, Rosario, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Peeters, Petra H., Numans, Mattijs E., Bueno-de-Mesquita, H.B., van Oijen, M.G.H., Bamia, Christina, Benetou, Vassiliki, Trichopoulos, Dimitrios, Canzian, Federico, Kaaks, Rudolf, Boeing, Heiner, Bergmann, Manuela M., Lund, Eiliv, Ehrnström, Roy, Johansen, Dorthe, Hallmans, Göran, Stenling, Roger, Tjønneland, Anne, Overvad, Kim, Ostergaard, Jane Nautrup, Ferrari, Pietro, Fedirko, Veronika, Jenab, Mazda, Nesi, Gabriella, Riboli, Elio, and González, Carlos A.

Published
2012
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32. Pre-hospital antibiotic treatment and mortality caused by invasive meningococcal disease, adjusting for indication bias

Author

Matute-Cruz Petra, Martos Francisco, Sánchez-Cantalejo Emilio, Olalla Julián, Perea-Milla Emilio, Carmona-López Guadalupe, Fornieles Yolanda, Cayuela Aurelio, and García-Alegría Javier

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Mortality from invasive meningococcal disease (IMD) has remained stable over the last thirty years and it is unclear whether pre-hospital antibiotherapy actually produces a decrease in this mortality. Our aim was to examine whether pre-hospital oral antibiotherapy reduces mortality from IMD, adjusting for indication bias. Methods A retrospective analysis was made of clinical reports of all patients (n = 848) diagnosed with IMD from 1995 to 2000 in Andalusia and the Canary Islands, Spain, and of the relationship between the use of pre-hospital oral antibiotherapy and mortality. Indication bias was controlled for by the propensity score technique, and a multivariate analysis was performed to determine the probability of each patient receiving antibiotics, according to the symptoms identified before admission. Data on in-hospital death, use of antibiotics and demographic variables were collected. A logistic regression analysis was then carried out, using death as the dependent variable, and pre-hospital antibiotic use, age, time from onset of symptoms to parenteral antibiotics and the propensity score as independent variables. Results Data were recorded on 848 patients, 49 (5.72%) of whom died. Of the total number of patients, 226 had received oral antibiotics before admission, mainly betalactams during the previous 48 hours. After adjusting the association between the use of antibiotics and death for age, time between onset of symptoms and in-hospital antibiotic treatment, pre-hospital oral antibiotherapy remained a significant protective factor (Odds Ratio for death 0.37, 95% confidence interval 0.15–0.93). Conclusion Pre-hospital oral antibiotherapy appears to reduce IMD mortality.

Published
2009
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33. Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort

Author

Fortner, Renée T., Hüsing, Anika, Kühn, Tilman, Konar, Meric, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Fournier, Agnès, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, Orfanos, Philippos, Masala, Giovanna, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Bueno de Mesquita, H. Bas, Peeters, Petra H. M., Weiderpass, Elisabete, Gram, Inger T., Gavrilyuk, Oxana, Quirós, J. Ramón, Huerta Castaño, José María, Ardanaz, Eva, Larrañaga, Nerea, Luján Barroso, Leila, Sánchez-Cantalejo, Emilio, Tunå Butt, Salma, Borgquist, Signe, Idahl, Annika, Lundin, Eva, Khaw, Kay-Tee, Allen, Naomi E., Rinaldi, Sabina, Dossus, Laure, Gunter, Marc, Merritt, Melissa A., and Universitat de Barcelona

Subjects
Serum, Endometrial cancer, Càncer d'endometri, Marcadors bioquímics, Sèrum, Biochemical markers, Nutrició, Nutrition
Abstract

Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines and cytokines were evaluated in a step-wise backward selection process; biomarkers were retained at p < 0.157 indicating improvement in the Akaike information criterion (AIC). Improvement in discrimination was assessed using the C-statistic for all biomarkers alone, and change in C-statistic from addition of biomarkers to preexisting absolute risk estimates. We used internal validation with bootstrapping (1000-fold) to adjust for over-fitting. Adiponectin, estrone, interleukin-1 receptor antagonist, tumor necrosis factor-alpha and triglycerides were select-ed into the model. After accounting for over-fitting, discrimination was improved by 2.0 percentage points when all evaluated biomarkers were included and 1.7 percentage points in the model including the selected biomarkers. Models including etiologic markers on independent pathways and genetic markers may further improve discrimination.

Published
2017

34. Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort

Author

Carayol, Marion, primary, Leitzmann, Michael F., additional, Ferrari, Pietro, additional, Zamora-Ros, Raul, additional, Achaintre, David, additional, Stepien, Magdalena, additional, Schmidt, Julie A., additional, Travis, Ruth C., additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Bachlechner, Ursula, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Panico, Salvatore, additional, Quirós, J. Ramón, additional, Sánchez-Cantalejo, Emilio, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Arriola, Larraitz, additional, Agudo, Antonio, additional, Nilsson, Jan, additional, Melander, Olle, additional, Bueno-de-Mesquita, Bas, additional, Peeters, Petra H., additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Jenab, Mazda, additional, Key, Timothy J., additional, Scalbert, Augustin, additional, and Rinaldi, Sabina, additional

Published
2017
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35. Aromatic DNA adducts and breast cancer risk: a case-cohort study within the EPIC-Spain

Author

Agudo, Antonio, primary, Peluso, Marco, additional, Munnia, Armelle, additional, Luján-Barroso, Leila, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Navarro, Carmen, additional, Sánchez, María-José, additional, Quirós, J.Ramón, additional, Ardanaz, Eva, additional, Larrañaga, Nerea, additional, Tormo, María-José, additional, Chirlaque, María-Dolores, additional, Rodríguez-Barranco, Miguel, additional, Sánchez-Cantalejo, Emilio, additional, Cellai, Filippo, additional, Bonet, Catalina, additional, Sala, Núria, additional, and González, Carlos A., additional

Published
2017
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36. Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort

Author

Fortner, Renée T., primary, Hüsing, Anika, additional, Kühn, Tilman, additional, Konar, Meric, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Boutron-Ruault, Marie-Christine, additional, Severi, Gianluca, additional, Fournier, Agnès, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Benetou, Vasiliki, additional, Orfanos, Philippos, additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, H.Bas, additional, Peeters, Petra H.M., additional, Weiderpass, Elisabete, additional, Gram, Inger T., additional, Gavrilyuk, Oxana, additional, Quirós, J. Ramón, additional, Maria Huerta, José, additional, Ardanaz, Eva, additional, Larrañaga, Nerea, additional, Lujan-Barroso, Leila, additional, Sánchez-Cantalejo, Emilio, additional, Butt, Salma Tunå, additional, Borgquist, Signe, additional, Idahl, Annika, additional, Lundin, Eva, additional, Khaw, Kay-Tee, additional, Allen, Naomi E., additional, Rinaldi, Sabina, additional, Dossus, Laure, additional, Gunter, Marc, additional, Merritt, Melissa A., additional, Tzoulaki, Ioanna, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional

Published
2017
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37. A method for sensitivity analysis to assess the effects of measurement error in multiple exposure variables using external validation data

Author

Agogo, George O., primary, van der Voet, Hilko, additional, van ’t Veer, Pieter, additional, Ferrari, Pietro, additional, Muller, David C., additional, Sánchez-Cantalejo, Emilio, additional, Bamia, Christina, additional, Braaten, Tonje, additional, Knüppel, Sven, additional, Johansson, Ingegerd, additional, van Eeuwijk, Fred A., additional, and Boshuizen, Hendriek C., additional

Published
2016
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38. Use of Two-Part Regression Calibration Model to Correct for Measurement Error in Episodically Consumed Foods in a Single-Replicate Study Design: EPIC Case Study

Author

Agogo, George O, der Voet, Hilko van, Veer, Pieter Van't, Ferrari, Pietro, Leenders, Max, Muller, David C, Sánchez-Cantalejo, Emilio, Bamia, Christina, Braaten, Tonje, Knüppel, Sven, Johansson, Ingegerd, van Eeuwijk, Fred A, Boshuizen, Hendriek, LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA-SIB, Risk Assessment of Toxic and Immunomodulatory Agents, [Agogo,GO, Boshuizen,H] National Institute for Public Health and the Environment, Bilthoven, The Netherlands. [Agogo,GO, Voet,HV, Eeuwijk,FAV, Boshuizen,H] Biometris, Wageningen University and Research Center, Wageningen, The Netherlands.[Veer,PV, Boshuizen,H] Department of Human Nutrition, Wageningen University and Research Center, Wageningen, The Netherlands. [Ferrari,P] Nutritional Epidemiology Group, International Agency for Research on Cancer, Lyon, France. [Leenders,M] Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands. [Muller,DC] Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France. [Sánchez-Cantalejo,E] Andalusian School of Public Health, Granada, Spain. CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [Bamia,C] WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Braaten,T] Department of Community Medicine, University of Tromsø, Tromsø, Norway. [Knüppel,S] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Potsdam, Germany. [Johansson,I] Department of Odontology, Umea University, Umea, Sweden., However, the publication cost will be covered by Wageningen University and Research Centre, Biometris, P.O. Box 100, 6700 AC WAGENINGEN should the paper be accepted for a publication., LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA-SIB, and Risk Assessment of Toxic and Immunomodulatory Agents

Subjects
Male, Parametric Analysis, Medicin och hälsovetenskap, Nutrition and Disease, Calibration (statistics), Test Statistics, lcsh:Medicine, markers, Overfitting, Statistical Inference, outcomes, Medical and Health Sciences, Wiskundige en Statistische Methoden - Biometris, Mathematical and Statistical Techniques, Neoplasms, Surveys and Questionnaires, Voeding en Ziekte, Statistics, Medicine, Prospective Studies, lcsh:Science, Multidisciplinary, Maximum Likelihood Estimation, Regression analysis, Estudios Prospectivos, Replicate, Diseases::Neoplasms [Medical Subject Headings], Middle Aged, PE&RC, Neoplasias, Diet Records, Europe, Survival Rate, Biometris, nutrition, Physical Sciences, Calibration, instruments, Regression Analysis, Dieta, Female, dietary self-report, Statistics (Mathematics), Bayesian Statistics, Research Article, Adult, Heteroscedasticity, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], General Science & Technology, Logit, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], Research and Analysis Methods, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Nutrition Assessment [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies [Medical Subject Headings], Covariate, MD Multidisciplinary, Humans, cancer, Statistical Methods, Statistical Hypothesis Testing, Mathematical and Statistical Methods - Biometris, Aged, VLAG, disease, Observational error, Models, Statistical, business.industry, lcsh:R, Evaluación Nutricional, Feeding Behavior, Estudios Longitudinales, Estudios Epidemiológicos, Survival Analysis, Nutrition Assessment, lcsh:Q, Food Habits, business, Mathematics, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies [Medical Subject Headings], Generalized Linear Model
Abstract

Journal Article; In epidemiologic studies, measurement error in dietary variables often attenuates association between dietary intake and disease occurrence. To adjust for the attenuation caused by error in dietary intake, regression calibration is commonly used. To apply regression calibration, unbiased reference measurements are required. Short-term reference measurements for foods that are not consumed daily contain excess zeroes that pose challenges in the calibration model. We adapted two-part regression calibration model, initially developed for multiple replicates of reference measurements per individual to a single-replicate setting. We showed how to handle excess zero reference measurements by two-step modeling approach, how to explore heteroscedasticity in the consumed amount with variance-mean graph, how to explore nonlinearity with the generalized additive modeling (GAM) and the empirical logit approaches, and how to select covariates in the calibration model. The performance of two-part calibration model was compared with the one-part counterpart. We used vegetable intake and mortality data from European Prospective Investigation on Cancer and Nutrition (EPIC) study. In the EPIC, reference measurements were taken with 24-hour recalls. For each of the three vegetable subgroups assessed separately, correcting for error with an appropriately specified two-part calibration model resulted in about three fold increase in the strength of association with all-cause mortality, as measured by the log hazard ratio. Further found is that the standard way of including covariates in the calibration model can lead to over fitting the two-part calibration model. Moreover, the extent of adjusting for error is influenced by the number and forms of covariates in the calibration model. For episodically consumed foods, we advise researchers to pay special attention to response distribution, nonlinearity, and covariate inclusion in specifying the calibration model. Yes

Published
2014

39. Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Author

Duarte-Salles, Talita, primary, Misra, Sandeep, additional, Stepien, Magdalena, additional, Plymoth, Amelie, additional, Muller, David, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Baglietto, Laura, additional, Severi, Gianluca, additional, Boutron-Ruault, Marie-Christine, additional, Turzanski-Fortner, Renee, additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Aleksandrova, Krasimira, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Bamia, Christina, additional, Pala, Valeria, additional, Palli, Domenico, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Bueno-de-Mesquita, H.B(as)., additional, Peeters, Petra H., additional, Weiderpass, Elisabete, additional, Quirós, J. Ramón, additional, Agudo, Antonio, additional, Sánchez-Cantalejo, Emilio, additional, Ardanaz, Eva, additional, Gavrila, Diana, additional, Dorronsoro, Miren, additional, Werner, Mårten, additional, Hemmingsson, Oskar, additional, Ohlsson, Bodil, additional, Sjöberg, Klas, additional, Wareham, Nicholas J., additional, Khaw, Kay-Tee, additional, Bradbury, Kathryn E., additional, Gunter, Marc J., additional, Cross, Amanda J., additional, Riboli, Elio, additional, Jenab, Mazda, additional, Hainaut, Pierre, additional, and Beretta, Laura, additional

Published
2016
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40. Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study

Author

Lassale, Camille, primary, Gunter, Marc J., additional, Romaguera, Dora, additional, Peelen, Linda M., additional, Van der Schouw, Yvonne T., additional, Beulens, Joline W. J., additional, Freisling, Heinz, additional, Muller, David C., additional, Ferrari, Pietro, additional, Huybrechts, Inge, additional, Fagherazzi, Guy, additional, Boutron-Ruault, Marie-Christine, additional, Affret, Aurélie, additional, Overvad, Kim, additional, Dahm, Christina C., additional, Olsen, Anja, additional, Roswall, Nina, additional, Tsilidis, Konstantinos K., additional, Katzke, Verena A., additional, Kühn, Tilman, additional, Buijsse, Brian, additional, Quirós, José-Ramón, additional, Sánchez-Cantalejo, Emilio, additional, Etxezarreta, Nerea, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Bonet, Catalina, additional, Khaw, Kay-Tee, additional, Key, Timothy J., additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Lagiou, Pagona, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Fasanelli, Francesca, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, H. Bas, additional, Boer, Jolanda M. A., additional, Sonestedt, Emily, additional, Nilsson, Lena Maria, additional, Renström, Frida, additional, Weiderpass, Elisabete, additional, Skeie, Guri, additional, Lund, Eiliv, additional, Moons, Karel G. M., additional, Riboli, Elio, additional, and Tzoulaki, Ioanna, additional

Published
2016
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41. Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study

Author

Podmore, Clara, primary, Meidtner, Karina, additional, Schulze, Matthias B., additional, Scott, Robert A., additional, Ramond, Anna, additional, Butterworth, Adam S., additional, Di Angelantonio, Emanuele, additional, Danesh, John, additional, Arriola, Larraitz, additional, Barricarte, Aurelio, additional, Boeing, Heiner, additional, Clavel-Chapelon, Françoise, additional, Cross, Amanda J., additional, Dahm, Christina C., additional, Fagherazzi, Guy, additional, Franks, Paul W., additional, Gavrila, Diana, additional, Grioni, Sara, additional, Gunter, Marc J., additional, Gusto, Gaelle, additional, Jakszyn, Paula, additional, Katzke, Verena, additional, Key, Timothy J., additional, Kühn, Tilman, additional, Mattiello, Amalia, additional, Nilsson, Peter M., additional, Olsen, Anja, additional, Overvad, Kim, additional, Palli, Domenico, additional, Quirós, J. Ramón, additional, Rolandsson, Olov, additional, Sacerdote, Carlotta, additional, Sánchez-Cantalejo, Emilio, additional, Slimani, Nadia, additional, Sluijs, Ivonne, additional, Spijkerman, Annemieke M.W., additional, Tjonneland, Anne, additional, Tumino, Rosario, additional, van der A, Daphne L., additional, van der Schouw, Yvonne T., additional, Feskens, Edith J.M., additional, Forouhi, Nita G., additional, Sharp, Stephen J., additional, Riboli, Elio, additional, Langenberg, Claudia, additional, and Wareham, Nicholas J., additional

Published
2016
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42. Acrylamide and Glycidamide Hemoglobin Adducts and Epithelial Ovarian Cancer: A Nested Case–Control Study in Nonsmoking Postmenopausal Women from the EPIC Cohort

Author

Obón-Santacana, Mireia, primary, Lujan-Barroso, Leila, additional, Travis, Ruth C., additional, Freisling, Heinz, additional, Ferrari, Pietro, additional, Severi, Gianluca, additional, Baglietto, Laura, additional, Boutron-Ruault, Marie-Christine, additional, Fortner, Renée T., additional, Ose, Jennifer, additional, Boeing, Heiner, additional, Menéndez, Virginia, additional, Sánchez-Cantalejo, Emilio, additional, Chamosa, Saioa, additional, Castaño, José María Huerta, additional, Ardanaz, Eva, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Merritt, Melissa A., additional, Gunter, Marc J., additional, Trichopoulou, Antonia, additional, Papatesta, Eleni-Maria, additional, Klinaki, Eleni, additional, Saieva, Calogero, additional, Tagliabue, Giovanna, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Mattiello, Amalia, additional, Bueno-de-Mesquita, H.B., additional, Peeters, Petra H., additional, Onland-Moret, N. Charlotte, additional, Idahl, Annika, additional, Lundin, Eva, additional, Weiderpass, Elisabete, additional, Vesper, Hubert W., additional, Riboli, Elio, additional, and Duell, Eric J., additional

Published
2016
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43. Life-course social position, obesity and diabetes risk in the EPIC-Spain Cohort

Author

Cirera, Lluís, primary, Huerta, José María, additional, Chirlaque, María Dolores, additional, Molina-Montes, Esther, additional, Altzibar, Jone Miren, additional, Ardanaz, Eva, additional, Gavrila, Diana, additional, Colorado-Yohar, Sandra, additional, Barricarte, Aurelio, additional, Arriola, Larraitz, additional, Quirós, José R., additional, Sánchez-Cantalejo, Emilio, additional, Sánchez, María José, additional, Agudo, Antonio, additional, and Navarro, Carmen, additional

Published
2015
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44. An epidemiological model for prediction of endometrial cancer risk in Europe

Author

Hüsing, Anika, primary, Dossus, Laure, additional, Ferrari, Pietro, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Fagherazzi, Guy, additional, Baglietto, Laura, additional, Schock, Helena, additional, Chang-Claude, Jenny, additional, Boeing, Heiner, additional, Steffen, Annika, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Katsoulis, Michalis, additional, Krogh, Vittorio, additional, Palli, Domenico, additional, Panico, Salvatore, additional, Onland-Moret, N. Charlotte, additional, Peeters, Petra H., additional, Bueno-de-Mesquita, H. Bas, additional, Weiderpass, Elisabete, additional, Gram, Inger T., additional, Ardanaz, Eva, additional, Obón-Santacana, Mireia, additional, Navarro, Carmen, additional, Sánchez-Cantalejo, Emilio, additional, Etxezarreta, Nerea, additional, Allen, Naomi E., additional, Khaw, Kay Tee, additional, Wareham, Nick, additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Merritt, Melissa A., additional, Gunter, Marc, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional

Published
2015
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45. Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Author

Arrebola, Juan P., primary, Fernández, Mariana F., additional, Martín-Olmedo, Piedad, additional, Molina-Molina, José Manuel, additional, Sánchez-Pérez, María J., additional, Sánchez-Cantalejo, Emilio, additional, Molina-Portillo, Elena, additional, Expósito, José, additional, Bonde, Jens Peter, additional, and Olea, Nicolás, additional

Published
2014
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46. Factores asociados al uso de la vía pulmonar e intravenosa en una muestra de consumidores de heroína en Granada

Author

March Cerdà, Joan Carles, Oviedo-Joekes, Eugenia, Romero Vallecillos, Manuel, and Sánchez-Cantalejo, Emilio

Subjects
Aislamiento social, Heroin, Social isolation, Heroína, Drogadicción, Drug addiction, Heroin addiction, Adicción a la heroína
Abstract

Fundamento: En los últimos años el consumo de heroína en España se ha estabilizado y el uso de la vía inyectada ha disminuido. No obstante existen importantes diferencias entre comunidades y entre los consumidores por la vía inyectada. El objetivo del presente estudio es conocer vías de administración de heroína en una muestra intencional de usuarios en situación de exclusión social y algunas de las variables que se asocian con ellas. Métodos: La muestra se compone de 285 participantes (hombres 82,8%; edad media 36,06). El estudio se llevó a cabo en la ciudad de Granada entre julio y octubre de 2002. Se realizaron entrevistas estructuradas por trabajadores de calle y personas conocedoras del medio (iguales), utilizando la técnica de «bola de nieve». Resultados: El 48,4% de los participantes consumen heroína por vía pulmonar e intravenosa; el 25,6% la consumen sólo por vía pulmonar; y un 25,6% sólo intravenosa. Tras un análisis de regresión se observa que las mujeres, los participantes más jóvenes y los que se han iniciado más tarde en el consumo son quienes menos tienden a utilizar la vía intravenosa. De los participantes que se iniciaron con inhalación el 21,5% actualmente además de inhalar también se inyectan, y el 79,5% restante se mantiene en la vía por inhalación. Conclusiones: Las personas en situación de exclusión social utilizan la vía intravenosa en porcentajes superiores al resto de la comunidad andaluza. Background: Heroin use has stabilized in recent years in Spain, and the use of injected heroin having decreased. Nevertheless, major differences exist among different Autonomous Communities and among injected heroin users profile. This study is aimed at ascertaining the forms of heroin use (how administered) in an intentional sample of users in a situation of social exclusion and some variables related to said forms of use. Methods: The sample was comprised of 285 participants (82.8% males; average age 36.06). This study was conducted in the city of Granada in July-October 2002. Structured surveys conducted by on-the-street interviewers and individuals having knowledge of the environment («peers») using the «snowball» technique. Results: A total of 48.4% of the participants alternate inhaled and intravenous heroin use; 25.6% using only inhaled and 25.6% only intravenous. Following a regression analysis, it was found that the females, the youngest users and those having started use at an older age were at less risk of intravenous heroin use. A total of 21.5% of the participants who started using heron in inhaled form, also currently use both the injected and inhaled forms, the remaining 79.5% continue to use the inhaled form. Conclusions: Among individuals in a situation of social exclusion the intravenous form exceeds the estimated percentages in the Autonomous Community of Andalusia.

Published
2005

47. Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: Results from the EPIC cohort study

Author

Sanikini, Harinakshi, primary, Dik, Vincent K., additional, Siersema, Peter D., additional, Bhoo-Pathy, Nirmala, additional, Uiterwaal, Cuno S.P.M., additional, Peeters, Petra H.M., additional, González, Carlos A., additional, Zamora-Ros, Raul, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Boutron-Ruault, Marie-Christine, additional, Fagherazzi, Guy, additional, Racine, Antoine, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Trichopoulos, Dimitrios, additional, Lagiou, Pagona, additional, Palli, Domenico, additional, Grioni, Sara, additional, Vineis, Paolo, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Weiderpass, Elisabete, additional, Skeie, Guri, additional, Braaten, Tonje, additional, Huerta, José María, additional, Sánchez-Cantalejo, Emilio, additional, Barricarte, Aurelio, additional, Sonestedt, Emily, additional, Wallstrom, Peter, additional, Nilsson, Lena Maria, additional, Johansson, Ingegerd, additional, Bradbury, Kathryn E, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Huybrechts, Inge, additional, Freisling, Heinz, additional, Cross, Amanda J., additional, Riboli, Elio, additional, and Bueno-de-Mesquita, H. Bas, additional

Published
2014
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48. Variation atABOhisto-blood group andFUTloci and diffuse and intestinal gastric cancer risk in a European population

Author

Duell, Eric J., primary, Bonet, Catalina, additional, Muñoz, Xavier, additional, Lujan-Barroso, Leila, additional, Weiderpass, Elisabete, additional, Boutron-Ruault, Marie-Christine, additional, Racine, Antoine, additional, Severi, Gianluca, additional, Canzian, Federico, additional, Rizzato, Cosmeri, additional, Boeing, Heiner, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Argüelles, Marcial, additional, Sánchez-Cantalejo, Emilio, additional, Chamosa, Saioa, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Travis, Rutch C., additional, Trichopoulou, Antonia, additional, Trichopoulos, Dimitrios, additional, Yiannakouris, Nikos, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, H Bas, additional, Siersema, Peter D., additional, Peeters, Petra H.M., additional, Ohlsson, Bodil, additional, Lindkvist, Björn, additional, Johansson, Ingegerd, additional, Ye, Weimin, additional, Johansson, Matthias, additional, Fenger, Claus, additional, Riboli, Elio, additional, Sala, Núria, additional, and González, Carlos A., additional

Published
2014
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49. Aromatic adducts and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort

Author

Gilbertson, Tamra, primary, Peluso, Marco E.M., additional, Munia, Armelle, additional, Luján-Barroso, Leila, additional, Sánchez, María-José, additional, Navarro, Carmen, additional, Amiano, Pilar, additional, Barricarte, Aurelio, additional, Quirós, J.Ramón, additional, Molina-Montes, Esther, additional, Sánchez-Cantalejo, Emilio, additional, Tormo, María-José, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Dorronsoro, Miren, additional, Confortini, Massimo, additional, Bonet, Catalina, additional, Sala, Núria, additional, González, Carlos A., additional, and Agudo, Antonio, additional

Published
2014
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50. Genetic association of gastric cancer with miRNA clusters including the cancer-related genesMIR29, MIR25, MIR93andMIR106: Results from the EPIC-EURGAST study

Author

Espinosa-Parrilla, Yolanda, primary, Muñoz, Xavier, additional, Bonet, Catalina, additional, Garcia, Nadia, additional, Venceslá, Adoración, additional, Yiannakouris, Nikos, additional, Naccarati, Alessio, additional, Sieri, Sabina, additional, Panico, Salvatore, additional, Huerta, José M., additional, Barricarte, Aurelio, additional, Menéndez, Virginia, additional, Sánchez-Cantalejo, Emilio, additional, Dorronsoro, Miren, additional, Brennan, Paul, additional, Duarte-Salles, Talita, additional, Bas Bueno-de-Mesquita, H., additional, Weiderpass, Elisabete, additional, Lund, Eiliv, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Racine, Antoine, additional, Numans, Mattijs E., additional, Tumino, Rosario, additional, Canzian, Federico, additional, Campa, Daniele, additional, Sund, Malin, additional, Johansson, Mattias, additional, Ohlsson, Bodil, additional, Lindkvist, Björn, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Palli, Domenico, additional, Travis, Ruth C., additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Boeing, Heiner, additional, Nesi, Gabriella, additional, Riboli, Elio, additional, Gonzalez, Carlos A., additional, and Sala, Núria, additional

Published
2014
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