43 results on '"Sánchez-Barba M"'
Search Results
2. Results of allogeneic stem cell transplantation in the Spanish MDS registry: Prognostic factors for low risk patients
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Díez Campelo, M., Sánchez-Barba, M., de Soria, V. Gómez-García, Martino, R., Sanz, G., Insunza, A., Bernal, T., Duarte, R., Amigo, M.L., Xicoy, B., Tormo, M., Iniesta, F., Bailén, A., Benlloch, L., Córdoba, I., López-Villar, O., and del Cañizo, M.C.
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- 2014
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3. The degree of neutropenia has a prognostic impact in low risk myelodysplastic syndrome
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Cordoba, I., Gonzalez-Porras, J.R., Such, E., Nomdedeu, B., Luño, E., de Paz, R., Carbonell, F., Vallespi, T., Ardanaz, M., Ramos, F., Marco, V., Bonanad, S., Sanchez-Barba, M., Costa, D., Bernal, T., Sanz, G.F., and Cañizo, M.C.
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- 2012
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4. Development of a List of Look-alike Drug Names With Recommended Tall Man Letters
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Otero López, M.J., Martín Muñoz, R., Sánchez Barba, M., Abad Sazatornil, R., Andreu Crespo, A., Arteta Jiménez, M., Bermejo Vicedo, T., and Cajaraville Ordoñana, G.
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- 2011
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5. Clinical and epidemiological characteristics of adult patients hospitalized for erysipelas and cellulitis
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Perelló-Alzamora, M.-R., Santos-Duran, J.-C., Sánchez-Barba, M., Cañueto, J., Marcos, M., and Unamuno, P.
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- 2012
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6. INCIDENCE AND RISK FACTORS FOR LIFE-THREATENING BLEEDING AFTER ALLOGENEIC STEM CELL TRANSPLANT: PH-O076
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Labrador, J., Sánchez-Barba, M., López-Corral, L., Vázquez, L., Sánchez-Guijo, F., Pérez-López, E., Cabrero-Calvo, M., López-Godino, O., Guerrero, C., Alberca, I., del Cañizo, C., Caballero, D., and González-Porras, J.-R.
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- 2014
7. Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation
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Caballero JC, Sánchez Barba M, Hernández Sánchez JM, Such E, Janusz K, Sanz G, Cabrero M, Chillón C, Cervera J, Hurtado AM, Jerez A, Calderón Cabrera C, Valcárcel D, Lumbreras E, Abáigar M, López Cadenas F, Hernández Rivas JM, Del Cañizo MC, and Díez Campelo M
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hemic and lymphatic diseases ,Allogeneic hematopoietic stem cell transplantation, Chronic graft-versus-host disease, Myelodysplastic syndromes, Somatic mutations, TP53 - Abstract
Somatic mutations in patients with myelodysplastic syndromes (MDS) undergoing allogeneic hematopoietic stem cell transplantation (HSTC) are associated with adverse outcome, but the role of chronic graft-versus-host disease (cGVHD) in this subset of patients remains unknown. We analyzed bone marrow samples from 115 patients with MDS collected prior to HSCT using next-generation sequencing. Seventy-one patients (61%) had at least one mutated gene. We found that patients with a higher number of mutated genes (more than 2) had a worse outcome (2years overall survival [OS] 54.8% vs. 31.1%, p = 0.035). The only two significant variables in the multivariate analysis for OS were TET2 mutations (p = 0.046) and the development of cGVHD, considered as a time-dependent variable (p 0.001), correlated with a worse and a better outcome, respectively. TP53 mutations also demonstrated impact on the cumulative incidence of relapse (CIR) (1year CIR 47.1% vs. 9.8%, p = 0.006) and were related with complex karyotype (p = 0.003). cGVHD improved the outcome even among patients with more than 2 mutated genes (1-year OS 88.9% at 1year vs. 31.3%, p = 0.02) and patients with TP53 mutations (1-year CIR 20% vs. 42.9%, p = 0.553). These results confirm that cGVHD could ameliorate the adverse impact of somatic mutations in patients with MDS with HSCT.
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- 2019
8. 41 - Chronic GVHD Could Ameliorate the Impact of Adverse Somatic Mutations in Patients with Myelodysplastic Syndromes and Hematopoietic Stem Cell Transplantation
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Caballero Berrocal, J.C., Sánchez Barba, M., Hernández Sánchez, J.M., Del Rey, M., Janusz, K., Chillón, C., Such, E., Sanz, G., Hurtado, A.M., Calderón Cabrera, C., Valcárcel, D., Lumbreras, E., Robledo, C., Abáigar, M., López Cadenas, F., Cabrero, M., Redondo-Guijo, A., Hernández Rivas, J.M., Del Cañizo, M.C., and Díez Campelo, M.
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- 2017
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9. Chronic GVHD Could Ameliorate the Impact of Adverse Somatic Mutations in Patients with Myelodysplastic Syndromes and Hematopoietic Stem Cell Transplantation
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Caballero Berrocal, J.C., primary, Sánchez Barba, M., additional, Hernández Sánchez, J.M., additional, Del Rey, M., additional, Janusz, K., additional, Chillón, C., additional, Such, E., additional, Sanz, G., additional, Hurtado, A.M., additional, Calderón Cabrera, C., additional, Valcárcel, D., additional, Lumbreras, E., additional, Robledo, C., additional, Abáigar, M., additional, López Cadenas, F., additional, Cabrero, M., additional, Redondo-Guijo, A., additional, Hernández Rivas, J.M., additional, Del Cañizo, M.C., additional, and Díez Campelo, M., additional
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- 2017
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10. What is the Outcome of Patients in the Intermediate IPSS-R Score Group? Spanish Approach for Better Stratification with Classical Tools
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Guijo, A.M. Redondo, primary, Sánchez-Barba, M., additional, Santillana, G. Sanz, additional, Bernal, T., additional, Sangerman, M. Arnan, additional, Ortega, F. Ramos, additional, Olivé, C. Pedro, additional, Lozano, M.L. Amigo, additional, Betes, V. Marco, additional, Valcárcel, D., additional, Ardanaz, M., additional, Brunet, S., additional, Lleonart, J. Bargay, additional, Tormo, M., additional, Xicoy, B., additional, Nomdedeu, M., additional, Cadenas, F. López, additional, Berrocal, J.C. Caballero, additional, Cañizo, M.C.D., additional, and Díez-Campelo, M., additional
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- 2017
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11. PD-031: Quality of life, health status and work in head and neck cancer survivors treated with radiotherapy
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Matías-Pérez, A., primary, Díaz de Tudanca, B.G., additional, Gallego-Herreros, G., additional, Sánchez-Barba, M., additional, Soria-Carreras, P., additional, Nieto-Palacios, A., additional, Rodríguez-Gutierrez, A., additional, and Pérez-Romasanta, L.A., additional
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- 2017
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12. Quality of life in head and neck cancer survivors treated with radiotherapy
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Matías-Pérez, A., primary, Díaz de Tudanca, B.G., additional, Gallego-Herreros, G., additional, Sánchez-Barba, M., additional, Soria-Carreras, P., additional, Nieto-Palacios, A., additional, Rodríguez-Gutierrez, A., additional, and Pérez-Romasanta, L.A., additional
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- 2017
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13. Prognostic factors associated with mortality in patients with severe trauma: From prehospital care to the Intensive Care Unit
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González-Robledo, J., primary, Martín-González, F., additional, Moreno-García, M., additional, Sánchez-Barba, M., additional, and Sánchez-Hernández, F., additional
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- 2015
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14. Biomarkers for the prediction of acute kidney injury: Is canonical biplot analyses a useful tool?
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Pescador, M., primary, Ramos, M., additional, Arias, M., additional, Gómez-Alamillo, C., additional, Sánchez-Barba, M., additional, Quiros, Y., additional, Blanco-Gozalo, V., additional, Pieto, M., additional, Vicente-Vicente, L., additional, Casanova, A.G., additional, López-Hernández, F.J., additional, and Morales, A.I., additional
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- 2015
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15. Factores pronósticos relacionados con la mortalidad del paciente con trauma grave: desde la atención prehospitalaria hasta la Unidad de Cuidados Intensivos
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González-Robledo, J., primary, Martín-González, F., additional, Moreno-García, M., additional, Sánchez-Barba, M., additional, and Sánchez-Hernández, F., additional
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- 2015
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16. 2846 Retrospective study of prophylactic neck irradiation of Head and Neck squamous cell carcinomas in the postoperative setting
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Matís-Pérez, A., primary, Soria-Carreras, P., additional, Blanco-Villar, M., additional, Matskov, K., additional, Gil-Restrepo, C., additional, Alonso-Rodríguez, O., additional, Rodríguez-García, S., additional, Cigarral-García, C., additional, Macís-Herníndez, V., additional, Pérez-Romasanta, L., additional, and Sánchez-Barba, M., additional
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- 2015
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17. 261 - What is the Outcome of Patients in the Intermediate IPSS-R Score Group? Spanish Approach for Better Stratification with Classical Tools
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Guijo, A.M. Redondo, Sánchez-Barba, M., Santillana, G. Sanz, Bernal, T., Sangerman, M. Arnan, Ortega, F. Ramos, Olivé, C. Pedro, Lozano, M.L. Amigo, Betes, V. Marco, Valcárcel, D., Ardanaz, M., Brunet, S., Lleonart, J. Bargay, Tormo, M., Xicoy, B., Nomdedeu, M., Cadenas, F. López, Berrocal, J.C. Caballero, Cañizo, M.C.D., and Díez-Campelo, M.
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- 2017
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18. 1936 - Quality of life in head and neck cancer survivors treated with radiotherapy
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Matías-Pérez, A., Díaz de Tudanca, B.G., Gallego-Herreros, G., Sánchez-Barba, M., Soria-Carreras, P., Nieto-Palacios, A., Rodríguez-Gutierrez, A., and Pérez-Romasanta, L.A.
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- 2017
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19. Elaboración de una relación de nombres de medicamentos similares en los que se recomienda utilizar letras mayúsculas resaltadas
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Otero López, M.J., primary, Martín Muñoz, R., additional, Sánchez Barba, M., additional, Abad Sazatornil, R., additional, Andreu Crespo, A., additional, Arteta Jiménez, M., additional, Bermejo Vicedo, T., additional, and Cajaraville Ordoñana, G., additional
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- 2011
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20. Los seglares y la evangelización de América: los conquistadores
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Hernández-Sánchez-Barba, M. (Mario)
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- Seglares, Evangelización, América
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- 1990
21. Transcultural adaptation and theoretical models validation of the Spanish version of the Self-Care of Diabetes Inventory.
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Martínez-Tofé J, Ausili D, Soto-Ruiz N, Santolalla-Arnedo I, Durante A, di Nitto M, Lysanets Y, de Viñaspre-Hernández RR, Tejada-Garrido CI, Sánchez Barba M, Gea-Caballero V, and Juárez-Vela R
- Abstract
Background: For patients with diabetes mellitus, self-care is crucial because it prevents complications and helps preserve quality of life. Clinicians and researchers require effective tools for assessing self-care behaviors across various dimensions to identify individual needs and maximize resource allocation. The aim of this study was to evaluate the validity and reliability of the Spanish version of the Self-Care of Diabetes Inventory (SCODI)., Methods: Two hundred eighteen participants with DMT1 and DMT2 who were recruited through convenience sampling from a university hospital participated in our cross-sectional study. After translation and cultural adaptation, the enrolled patients answered the questions. We performed an exploratory factor analysis (EFA) on each of the SCODI scales and Confirmatory factor analysis (CFA) was performed using our models which appropriate fit indices., Results: The original structure of the four-dimensions tool was confirmed. The overall consistency across the four scales was assessed by Cronbach's alpha: self-care maintenance (0.766), self-care monitoring (0.790), self-care management (0.771), and self-care confidence (0.936). The model fit yielded a chi-square index of 1.028 with 773 degrees of freedom. Confirmatory factor analysis showed a good fit, thereby affirming the reliability of the model., Conclusion: The internal consistency and reliability of the SCODI Spanish version are deemed adequate. This tool is appropriate when it is desired to evaluate the self-care practices of Spanish persons suffering from diabetes due to its good psychometric qualities., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Martínez-Tofé, Ausili, Soto-Ruiz, Santolalla-Arnedo, Durante, di Nitto, Lysanets, de Viñaspre-Hernández, Tejada-Garrido, Sánchez Barba, Gea-Caballero and Juárez-Vela.)
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- 2024
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22. The Chem-Sex Inventory Scale (CSI): A Tool to Assess the Mental Health Risk of Chemsex Behaviors in Men Who Have Sex with Men.
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Del Pozo-Herce P, Baca-García E, Martínez-Sabater A, Pérez-Elvira R, Gea-Caballero V, Chover-Sierra E, Satústegui-Dordá PJ, Tovar-Reinoso A, Rodríguez-Velasco FJ, Sánchez-Barba M, Pérez J, and Juárez-Vela R
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Background : Chemsex has been defined as the deliberate use of drugs for prolonged sexual intercourse between gay and bisexual men and other men who have sex with men (MSM). Drugs associated with chemsex can trigger mental health problems such as anxiety, depression, risk of psychosis and suicidal ideation, social isolation, stigmatization, and even loss of impulse control and lack of coping strategies. Currently, the increase in illicit drugs in a sexual context is considered an outbreak of a public health emergency. Objective : The aim of this study is the construction and validation of the Chem-Sex Inventory (CSI), a new scale to assess the mental health risk of chemsex behaviors. Methods : A cross-sectional design was conducted to study 563 participants. Data were collected through an online questionnaire between January and April 2023, and the construct validity of the CSI was assessed through exploratory and confirmatory factor analysis. Results : The sample was, on average, 36 years old (SD: ±9.2). The majority of gender identity was cisgender (97.7%). A factor structure was found that can be summarized in four dimensions: emotional instability, risk of psychosis, altered body perception, and risk of suicide. The confirmatory factor analysis (CFA) presents adequate reliability values, with a Cronbach's alpha above 0.87 for all dimensions and a McDonald's omega above 0.88 with a good fit of the 42 items. Conclusions : Our study has shown that the Chem-Sex Inventory (CSI) scale has factorial validity and could be used in clinical practice and research to measure the behavioral contribution of the chemsex phenomenon in MSM.
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- 2024
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23. Descriptive study on substance uses and risk of sexually transmitted infections in the practice of Chemsex in Spain.
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Del Pozo-Herce P, Baca-García E, Martínez-Sabater A, Chover-Sierra E, Gea-Caballero V, Curto-Ramos J, Czapla M, Karniej P, Martínez-Tofe J, Sánchez-Barba M, de Viñaspre RR, and Juárez-Vela R
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- Humans, Spain epidemiology, Male, Cross-Sectional Studies, Adult, Surveys and Questionnaires, Sexual Behavior statistics & numerical data, Middle Aged, Young Adult, Adolescent, Sexual and Gender Minorities statistics & numerical data, Risk Factors, Risk-Taking, Sexually Transmitted Diseases epidemiology, Substance-Related Disorders epidemiology, Homosexuality, Male statistics & numerical data
- Abstract
Background: In recent years, there has been an increasing use of sex-related substances (known as "Chemsex") to facilitate, intensify, and prolong the sexual experience of men who have sex with men. This phenomenon poses a public health problem, increasing the risk of sexually transmitted infections (STIs) and mental disorders., Objective: The primary aim of this study was to delve into the correlation between substance use and sexual health, specifically examining the association between different substances used and the risk of sexually transmitted infections (STIs) in the context of Chemsex in Spain., Methods: An observational, descriptive, cross-sectional study was conducted among 563 Spanish participants between January and April 2023. Non-probabilistic purposive sampling was used by the investigators. The researchers administered a questionnaire to men who have sex with men who use substances, especially in the sexual sphere, in all the autonomous communities of Spain., Results: 14.7% reported having practiced slamsex in the last year, and 17.94% were diagnosed with a Sexually Transmitted Infection in the previous 6 months. Of these, 21% were on PREP treatment, with the main STIs being gonorrhea ( p < 0.001), chlamydia ( p < 0.001), genital herpes ( p = 0.020), and syphilis ( p < 0.001). The 63.7% used methamphetamines as the main drug in the practice of chemsex., Discussion: Chemsex in Spain is linked to a high prevalence of STIs, especially gonorrhea and chlamydia, even among those on PrEP treatment. The use of various drugs during chemsex, such as amyl nitrite, GHB, ecstasy, and others, correlates with higher rates of STIs, highlighting the need for interventions to reduce risk and harm. The drugs most associated with slamsex include ketamine, mephedrone, and methamphetamine, underscoring the importance of addressing the risk behaviors associated with this activity., Conclusion: This study shows that chemsex appears to be associated with a high prevalence among men who have sex with men. Who use multiple substances in a sexual context, and are particularly exposed to sexually transmitted infections (STIs), indicating a particular need for STI prevention and care in this group., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 del Pozo-Herce, Baca-García, Martínez-Sabater, Chover-Sierra, Gea-Caballero, Curto-Ramos, Czapla, Karniej, Martínez-Tofe, Sánchez-Barba, de Viñaspre and Juárez-Vela.)
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- 2024
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24. Outcomes and effect of somatic mutations after erythropoiesis stimulating agents in patients with lower-risk myelodysplastic syndromes.
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Caballero JC, Dávila J, López-Pavía M, Such E, Bernal T, Ramos F, Calabuig M, Hernández Sánchez JM, Pomares H, Sánchez Barba M, Abáigar M, González B, Merchán B, Sancho-Tello R, Callejas M, Muñoz-Novas C, Cerveró C, Sanz G, Hernández Rivas JM, and Díez Campelo M
- Abstract
Background: Erythropoiesis stimulating agents (ESAs) are the first-line therapy in patients with lower-risk myelodysplastic syndromes (LR-MDS). Some predictive factors for ESAs response have been identified. Type and number of somatic mutations have been associated with prognosis and response to therapies in MDS patients., Objectives: The objective was to evaluate the outcomes after ESAs in patients with LR-MDS and to address the potential predictive value of somatic mutations in ESAs-treated patients., Design: Multi-center retrospective study of a cohort of 722 patients with LR-MDS included in the SPRESAS (Spanish Registry of Erythropoietic Stimulating Agents Study) study. Retrospective analysis of 65 patients with next generation sequencing (NGS) data from diagnosis., Methods: ESAs' efficacy and safety were evaluated in patients receiving ESAs and best supportive care (BSC). To assess the potential prognostic value of somatic mutations in erythroid response (ER) rate and outcome, NGS was performed in responders and non-responders., Results: ER rate for ESAs-treated patients was 65%. Serum erythropoietin (EPO) level <200 U/l was the only variable significantly associated with a higher ER rate (odds ratio, 2.45; p = 0.036). Median overall survival (OS) in patients treated with ESAs was 6.7 versus 3.1 years in patients receiving BSC ( p < 0.001). From 65 patients with NGS data, 57 (87.7%) have at least one mutation. We observed a trend to a higher frequency of ER among patients with a lower number of mutated genes (40.4% in <3 mutated genes versus 22.2% in ⩾3; p = 0.170). The presence of ⩾3 mutated genes was also significantly associated with worse OS (hazard ratio, 2.8; p = 0.015), even in responders. A higher cumulative incidence of acute myeloid leukemia progression at 5 years was also observed in patients with ⩾3 mutated genes versus <3 (33.3% and 10.7%, respectively; p < 0.001)., Conclusion: This large study confirms the beneficial effect of ESAs and the adverse effect of somatic mutations in patients with LR-MDS., Competing Interests: The authors declare that there is no conflict of interest., (© The Author(s), 2024.)
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- 2024
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25. Exploring the Link between Interoceptive Body Awareness and Suicidal Orientation in University Students: A Cross-Sectional Study.
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Montoya-Hurtado OL, Gómez-Jaramillo N, Criado-Gutiérrez JM, Pérez J, Sancho-Sánchez C, Sánchez-Barba M, Tejada-Garrido CI, Criado-Pérez L, Sánchez-González JL, Santolalla-Arnedo I, Del Pozo-Herce P, and Juárez-Vela R
- Abstract
Introduction: The transition to college life can impact the mental health of students. There are mental health care strategies that promote connection with the body's internal signals, which can help to improve mental well-being, manage emotions, and reduce the risk of suicide in university students., Aim: This study aimed to examine the association between interoceptive body awareness variables and suicidal orientation in a sample of 169 undergraduate students in Colombia., Methods: An observational, cross-sectional study was conducted in 2023 with Colombian students as the participants., Results: The findings revealed a significant and moderately negative correlation between the Multidimensional Assessment of Interoceptive Awareness (MAIA) total score and the Inventory of Suicide Orientation (ISO-30) total score (r = -0.54, p < 0.001). Confidence and self-regulation were identified as the most influential factors in the relationship between MAIA and ISO-30. Significant correlations were observed ( p < 0.001), indicating moderate correlation values ranging from -0.43 to -0.57., Discussion: Our findings support the existence of a negative correlation between interoceptive body awareness and suicidal orientation. Further research is needed to better understand this relationship and to develop specific interventions based on body awareness to prevent suicide orientation., Conclusion: There are practical implications associated with recognizing the importance of body awareness in relation to decreasing suicidal orientation, and multidisciplinary teams addressing mental health can incorporate this knowledge.
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- 2023
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26. Analysis of Psychological Well-Being from a Compositional Data Analysis Perspective: A New Approach.
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Cortés-Rodríguez M, Galindo-Villardón P, Sánchez-Barba M, Jarauta-Bragulat E, and Urchaga-Litago JD
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Well-being is a widely studied construct in psychology. In 1989, Carol Ryff proposed the "Scale of Psychological Well-Being (SPWB)", which has been validated in multiple languages. The instrument assesses six dimensions of psychological well-being: Self-acceptance, Positive Relationships with Others, Autonomy, Environmental Mastery, Purpose in Life, and Personal Growth. In this article, we propose to enrich the traditional approach of directly interpreting the raw scores in each dimension by incorporating Compositional Data Analysis. This new approach aims to identify "what proportion" of each dimension constitutes well-being, which will allow us to analyze the interactions between the different dimensions of well-being and balance among them. To achieve this, we introduce two position ratios (PR1 and PR2) and a general adjustment indicator called the General Indicator of Subjective Psychological Well-Being (GISPW), which characterizes individuals in a compositional manner, providing a fresh perspective in the interpretation of psychological test results, specifically those related to PWB. The proposal is illustrated with three cases taken from a study involving 628 university students who completed the psychological well-being scale questionnaire. The results show that the GISPW, PR1, and PR2 obtained offer relevant information about the overall balance of each case in the different dimensions.
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- 2023
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27. Application of the Delphi Method for Content Validity Analysis of a Questionnaire to Determine the Risk Factors of the Chemsex.
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Del Pozo-Herce P, Martínez-Sabater A, Chover-Sierra E, Gea-Caballero V, Satústegui-Dordá PJ, Saus-Ortega C, Tejada-Garrido CI, Sánchez-Barba M, Pérez J, Juárez-Vela R, Santolalla-Arnedo I, and Baca-García E
- Abstract
Chemsex is understood as "the intentional use of stimulant drugs to have sex for an extended time among gay, bisexual, and other men who have sex with men". It is a public health problem because of the increased incidence of cases and because of the consequences on the physical and mental health of those who practice it., Aim: This study aimed to analyze, with the help of the Delphi method, the content validity of a new instrument to assess the risk of behaviors associated with the chemsex phenomenon., Method: First, a bank of items identified from the literature was elaborated. Secondly, 50 experts with knowledge of the chemsex phenomenon at the national level were contacted. A Delphi group was formed with them to carry out two rounds of item evaluation. The linguistic evaluation (comprehension and appropriateness) was assessed using a Likert scale from 1 to 5 for each item. Items that did not reach a mean score of 4 were eliminated. Content assessment was calculated using each item's content validity index (CVI) and Aiken's V (VdA). A minimum CVI and VdA value of 0.6 was established to include the items in the questionnaire., Results: A total of 114 items were identified in the literature. In the first round of Delphi evaluation, 36 experts evaluated the items. A total of 58 items were eliminated for obtaining a CVI or VdA of less than 0.6, leaving 56 items. In a second Delphi round, 30 experts re-evaluated the 56 selected items, where 4 items were eliminated for being similar, and 10 items were also eliminated for not being relevant to the topic even though they had values higher than 0.6, leaving the scale finally composed of 52 items., Conclusion: A questionnaire has been designed to assess the risk of behaviors associated with the chemsex phenomenon. The items that make up the questionnaire have shown adequate content and linguistic validity. The Delphi method proved to be a helpful technique for the proposed objective.
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- 2023
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28. Predictive Value of Cervical Shear Wave Elastography in the Induction of Labor in Late-Term Pregnancy Nulliparous Women: Preliminary Results.
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Costas T, Rodríguez MO, Sánchez-Barba M, and Alcázar JL
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The prediction of induction of labor continues to be a paradigm nowadays. Bishop Score is the traditional widely spread method but with a low reliability. Ultrasound cervical assessment has been proposed as an instrument of measurement. Shear wave elastography (SWE) should be a promising tool in the prediction of the success of labor induction in nulliparous late-term pregnancies. Ninety-two women with nulliparous late-term pregnancies who were going to be induced were included in the study. A shear wave measurement of the cervix divided into six regions (inner, middle and outer in both cervical lips), cervical length and fetal biometry was performed by blinded investigators prior to routine hand cervical assessment (Bishop Score (BS)) and induction of labor. The primary outcome was success of induction. Sixty-three women achieved labor. Nine women did not, and they underwent a cesarean section due to failure to induce labor. SWE was significantly higher in the inner part of the posterior cervix ( p < 0.0001). SWE showed an area under the curve (AUC): 0.809 (0.677-0.941) in the inner posterior part. For CL, AUC was 0.816 (0.692-0.984). BS AUC was 0.467 (0.283-0.651). The ICC of inter-observer reproducibility was ≥0.83 in each region of interest (ROI). The cervix elastic gradient seems to be confirmed. The inner part of the posterior cervical lip is the most reliable region to predict induction of labor results in SWE terms. In addition, cervical length seems to be one of the most important procedures in the prediction of induction. Both methods combined could replace the Bishop Score.
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- 2023
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29. Exposure to Morphine and Cocaine Modify the Transcriptomic Landscape in Zebrafish Embryos.
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Calderon-Garcia AA, Perez-Fernandez M, Curto-Aguilera D, Rodriguez-Martin I, Sánchez-Barba M, and Gonzalez-Nunez V
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- Animals, Zebrafish metabolism, Transcriptome, Receptors, Opioid metabolism, Morphine pharmacology, Cocaine pharmacology
- Abstract
Morphine and other opioid analgesics are the drugs of election to treat moderate-to-severe pain, and they elicit their actions by binding to the opioid receptors. Cocaine is a potent inhibitor of dopamine, serotonin, and noradrenaline reuptake, as it blocks DAT, the dopamine transporter, causing an increase in the local concentration of these neurotransmitters in the synaptic cleft. The molecular effects of these drugs have been studied in specific brain areas or nuclei, but the systemic effects in the whole organism have not been comprehensively analyzed. This study aims to analyze the transcriptomic changes elicited by morphine (10 uM) and cocaine (15 uM) in zebrafish embryos. An RNAseq assay was performed with tissues extracts from zebrafish embryos treated from 5 hpf (hours post fertilization) to 72 hpf, and the most representative deregulated genes were experimentally validated by qPCR. We have found changes in the expression of genes related to lipid metabolism, chemokine receptor ligands, visual system, hemoglobins, and metabolic detoxification pathways. Besides, morphine and cocaine modified the global DNA methylation pattern in zebrafish embryos, which would explain the changes in gene expression elicited by these two drugs of abuse., (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2022
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30. Incidence of Neonatal Abstinence Syndrome (NAS) in Castilla y Leon (Spain).
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Moreno-Ramos M, Sánchez-Barba M, Sánchez RG, Mirón-Canelo JA, and González-Nuñez V
- Abstract
Introduction: Neonatal Abstinence Syndrome (NAS) is considered a Public Health problem that is defined as a group of symptoms that appear in the newborn due to withdrawal from intrauterine drug exposure., Objective: The aim of this study was to analyze the incidence of NAS in Castilla y León from 2000 to 2019., Methodology: Data of NAS cases in Castilla y León from 2000 to 2019 were obtained. NAS incidence per 1000 births was calculated and the correlation among data from different provinces and years was analyzed., Results: The cumulative incidence of NAS in Castilla y León per 1000 births between 2000-2019 was 0.91‱, with great interprovincial variability. The provinces of Zamora and Palencia stand out, with high incidence rates of NAS despite their low birth rates. The temporal trend points towards a decrease in incidence from 2000 to 2019. Opioids such as methadone, cannabis, benzodiazepines and poly-drug use are the most prevalent drugs causing NAS, and it has also been observed that methadone is being replaced by cannabis as the major cause of NAS cases at the University Hospital in Salamanca in recent years., Conclusions: The incidence of NAS in Castilla y León decreased in 2004 and remained constant until 2019, but it shows great interprovincial variability. It is necessary to implement a national NAS Registry to obtain comprehensive information regarding its incidence.
- Published
- 2021
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31. Early and late results of open surgical and endovascular treatment of infrarenal abdominal aortic aneurysms, selected according to surgical risk.
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Torres Hernández JA, Sánchez-Barba M, García-Alonso J, Sancho M, González-Porras JR, and Lozano Sanchez FS
- Abstract
Background: Open surgical repair (OSR) and endovascular aneurysm repair (EVAR) surgery are alternative treatments for infrarenal abdominal aortic aneurysm (IRAAA)., Objectives: To compare OSR and EVAR for the treatment of IRAAA., Methods: 119 patients with IRAAA were electively operated by the same surgeon between January 1, 2006 and December 31, 2015, following selection for OSR or EVAR according to surgical risk. Complications, reinterventions, failures, and early and late mortality were analyzed., Results: 63 OSR and 56 EVAR patients were analyzed. They were similar in terms of age (70 years), gender (92% men), and average diameter of IRAAA (6.5 cm), but with different comorbidities, surgical risk, and anatomy. EVAR was better than OSR regarding time in the operating theatre (177.5 vs. 233.3 minutes), need for transfusion (25 vs. 73%), and length of stay in ICU (1.3 vs. 3.3 days) and hospital (8.1 vs. 11.1 days). OSR allowed more associated procedures to be conducted simultaneously (19.0 vs. 1.8%). There were no significant differences between the groups with respect to complications (25.4 vs. 25.1%), reinterventions (3.2 vs. 5.2%), or early mortality (1.6 vs. 0%). During follow-up, OSR was associated with fewer revisions (3.13 vs. 4.21), angio-CTs (0.22 vs. 3.23), complications (6.4 vs. 37.5%), reinterventions (3.2 vs. 23.2%), and failures (1.6 vs. 10.7%), and had better survival (78.2 vs. 63.2%)., Conclusions: Correct selection of patients achieves excellent results because it avoids OSR in patients at high risk and avoids EVAR in patients with high anatomical complexity, achieving similar results in the perioperative period, but better results for OSR over the course of follow-up., Competing Interests: Conflicts of interest: No conflicts of interest declared concerning the publication of this article., (Copyright© 2021 The authors.)
- Published
- 2021
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32. A Computational Model of Tonal Tension Profile of Chord Progressions in the Tonal Interval Space.
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Navarro-Cáceres M, Caetano M, Bernardes G, Sánchez-Barba M, and Merchán Sánchez-Jara J
- Abstract
In tonal music, musical tension is strongly associated with musical expression, particularly with expectations and emotions. Most listeners are able to perceive musical tension subjectively, yet musical tension is difficult to be measured objectively, as it is connected with musical parameters such as rhythm, dynamics, melody, harmony, and timbre. Musical tension specifically associated with melodic and harmonic motion is called tonal tension. In this article, we are interested in perceived changes of tonal tension over time for chord progressions, dubbed tonal tension profiles . We propose an objective measure capable of capturing tension profile according to different tonal music parameters, namely, tonal distance, dissonance, voice leading, and hierarchical tension. We performed two experiments to validate the proposed model of tonal tension profile and compared against Lerdahl's model and MorpheuS across 12 chord progressions. Our results show that the considered four tonal parameters contribute differently to the perception of tonal tension. In our model, their relative importance adopts the following weights, summing to unity: dissonance (0.402), hierarchical tension (0.246), tonal distance (0.202), and voice leading (0.193). The assumption that listeners perceive global changes in tonal tension as prototypical profiles is strongly suggested in our results, which outperform the state-of-the-art models.
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- 2020
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33. Seven methods to determine the dimensionality of tests: application to the General Self-Efficacy Scale in twenty-six countries.
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Villegas Barahona G, González García N, Sánchez-García AB, Sánchez Barba M, and Galindo-Villardón MP
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- Cross-Cultural Comparison, Humans, Psychological Tests statistics & numerical data, Self Efficacy
- Abstract
Background: One of the most important concepts within Cognitive Social Theory as framed by Bandura is the perceived self-efficacy; this concept became widespread in 1981 when Mathias Jerusalem and Ralf Schwarzer, using 10 items, established a one-dimensional and universal construct of this scale. The main purpose of this study is to show that the General Self-Efficacy Scale (GSE) is not a one-dimensional and universal construct, as is currently assumed., Method: The data from 19,719 people from 26 countries were analyzed. In order to identify and understand invariance we applied seven multivariate statistical techniques., Results: The findings suggest the existence of a multidimensional structure and differential item functioning by country. Insofar as there is differential item functioning by country and it is not possible to universalize it, and there are several items on the scale that statistically constitute additional factors. The results confirm that the self-efficacy construct is neither universal nor unidimensional., Conclusions: A psychometric instrument must be valued and used with great care; the one in question is being used in a generalized way.
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- 2018
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34. Multiclassifier Systems for Predicting Neurological Outcome of Patients with Severe Trauma and Polytrauma in Intensive Care Units.
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González-Robledo J, Martín-González F, Sánchez-Barba M, Sánchez-Hernández F, and Moreno-García MN
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- Brain Injuries, Traumatic, Humans, Intensive Care Units, Sensitivity and Specificity, Multiple Trauma
- Abstract
This paper presents an ensemble based classification proposal for predicting neurological outcome of severely traumatized patients. The study comprises both the whole group of patients and a subgroup containing those patients suffering traumatic brain injury (TBI). Data was gathered from patients hospitalized in the Intensive Care Unit (ICU) of the University Hospital in Salamanca. Predictive models were induced from both epidemiologic and clinical variables taken at the emergency room and along the stay in the ICU. The large number of variables leads to a low accuracy in the classifiers even when feature selection methods are used. In addition, the presence of a much larger number of instances of one of the classes in the subgroup of TBI patients produces a significantly lesser precision for the minority class. Usual ways of dealing with the last problem is to use undersampling and oversampling strategies, which can lead to the loss of valuable data and overfitting problems respectively. Our proposal for dealing with these problems is based in the use of ensemble multiclassifiers as well as in the use of an ensemble playing the role of base classifier in multiclassifiers. The proposed strategy gave the best values of the selected quality measures (accuracy, precision, sensitivity, specificity, F-measure and area under the Receiver Operator Characteristic curve) as well as the closest values of precision for the two classes under study in the case of the classification from imbalanced data.
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- 2017
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35. Predictive Capacity of Cloninger's temperament and character inventory (TCI-R) in alcohol use disorder outcomes.
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Ávila Escribano JJ, Sánchez Barba M, Álvarez Pedrero A, López Villarreal A, Recio Pérez J, Rodríguez Rodilla M, and Fraile García E
- Subjects
- Adult, Aged, Female, Humans, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Treatment Outcome, Young Adult, Alcohol-Related Disorders psychology, Alcohol-Related Disorders therapy, Character, Personality Tests, Temperament
- Abstract
Objective: to investigate the ability to predict the outcome of alcohol use disorders through Cloninger's temperament and character inventory (TCI-R)., Methods: this is a prospective study consisting of 237 outpatients with alcohol use disorders who underwent follow-up treatment for 6 months and whose personality traits were studied using TCI-R. At the end of that period, the scores of each TCI-R trait were analyzed in terms of those who remained in treatment and those who dropped out., Results: The whole group scored highly in novelty seeking (NS) and harm avoidance (HA) and produced low scores in self-directedness (SD), these last traits are considered prominent. The drop-out group scored significantly (p=.004) higher in novelty seeking (NS) than the follow-up group. Also, when the score was higher than the 67 percentile the likelihood of abandoning the treatment was 1.07 times higher., Conclusions: Cloninger's temperament and character inventory is a good instrument to predict the outcome of treatment of patients with alcohol use disorders and the novelty seeking (NS) dimension is strongly related to therapeutic drop-out.
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- 2016
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36. Association of Lysyl Oxidase-Like 1 Gene Polymorphisms in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in a Spanish Population.
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de Juan-Marcos L, Escudero-Domínguez FA, Hernández-Galilea E, Cabrillo-Estévez L, Cruz-González F, Cieza-Borrella C, Sánchez-Barba M, and González-Sarmiento R
- Subjects
- Aged, Aged, 80 and over, Alleles, Case-Control Studies, Female, Genotype, Haplotypes, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymerase Chain Reaction, Spain, Amino Acid Oxidoreductases genetics, Exfoliation Syndrome genetics, Genetic Predisposition to Disease, Glaucoma, Open-Angle genetics, Polymorphism, Single Nucleotide, White People
- Abstract
Purpose: To evaluate the association of the lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) in a Spanish population with pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG)., Materials and Methods: The present case-control study included 100 Spanish patients (60 patients with XFS and 40 patients with XFG) and 90 control subjects. Genotypes of the three single nucleotide polymorphisms of LOXL1 (rs1048661, rs3825942, and rs2165241) were analyzed with direct sequencing., Results: The G allele and the GG genotype of SNP rs3825942 were detected at a statistically higher frequency in pseudoexfoliation patients than in control subjects (p = 3.36 × 10(-5), OR = 5.71, 95% CI: 2.30-14.18; p = 3.38 × 10(-5), OR = 6.91, 95% CI: 2.51-19.03 respectively). The T allele and the TT genotype of SNP rs2165241 presented at significantly higher frequencies in pseudoexfoliation patients than in controls (p = 2.50 × 10(-4), OR = 2.18, 95% CI: 1.43-3.33; p = 1.21 × 10(-2), OR = 2.13, 95% CI: 1.75-3.85 respectively). No significant association between XFS/XFG and the rs1048661 was observed. The GGT haplotype composed of all three risk alleles was determined to be significantly associated with pseudoexfoliation. The genotypic and allelic distributions of the three SNPs were similar between XFS and XFG., Conclusions: This is the first study associating two SNPs of LOXL1 (rs3825942 and rs2165241) and XFS/XFG in a Spanish population, confirming findings in patients from Europe. However rs1048661 SNP did not show an association with XFS.
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- 2016
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37. Comparative effect of two pan-class I PI3K inhibitors used as anticancer drugs on human T cell function.
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Blanco B, Herrero-Sánchez C, Rodríguez-Serrano C, Sánchez-Barba M, and Del Cañizo MC
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- Apoptosis drug effects, Cell Culture Techniques, Cell Cycle drug effects, Cell Proliferation drug effects, Cell Survival drug effects, Dose-Response Relationship, Drug, Humans, Interleukin-2 metabolism, Jurkat Cells, Lymphocyte Activation drug effects, T-Lymphocytes immunology, Th1 Cells drug effects, Th1 Cells immunology, Th2 Cells drug effects, Th2 Cells immunology, Aminopyridines pharmacology, Antineoplastic Agents pharmacology, Enzyme Inhibitors pharmacology, Gonanes pharmacology, Morpholines pharmacology, Phosphoinositide-3 Kinase Inhibitors, T-Lymphocytes drug effects
- Abstract
The phosphatidylinositol 3-kinase (PI3K) pathway is commonly deregulated in cancer and, thus, PI3K has been recognized as an attractive molecular target for novel anti-cancer therapies. However, the effect of PI3K inhibitors on T-cell function, a key component of antitumor immunity, has been scantly explored. The objective of this study was to investigate the effect on human T-cell activation of two PI3K inhibitors currently being tested in clinical trials: PX-866 and BKM120. Their activity against a leukemic T cell line was also assessed. For that purpose, Jurkat cells or anti-CD3/anti-CD28 stimulated human peripheral blood mononuclear cells were cultured in the presence of different concentrations of PX-866 or BKM120 and their effect on T-cell proliferation, apoptosis, expression of activation markers and cytokine secretion was analyzed by flow cytometry. In addition, Akt and Erk phosphorylation was analyzed by Western blotting. Both PX-866 and BKM120 decreased viability of Jurkat cells and blocked cell cycle progression. Regarding primary T cells, both compounds similarly inhibited expression of activation markers and cytokine secretion, although they did not induce apoptosis of stimulated T cells. Interestingly, we found differences in their ability to block T-cell proliferation and IL-2 secretion, exerting BKM120 a more potent inhibition. These disparate effects could be related to differences observed in PI3K/Akt and RAS/MEK/ERK signaling between PX-866 and BKM120 treated cells. Our results suggest that, when selecting a PI3K inhibitor for cancer therapy, immunosuppressive characteristics should be taken into account in order to minimize detrimental effects on immune function., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
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38. [Opinion survey on information, communication and treatment in an Emergency Department].
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García-García A, Arévalo-Velasco A, García-Iglesias MA, Sánchez-Barba M, Delgado-Vicente MA, Bajo-Bajo A, and Diego-Robledo F
- Subjects
- Adult, Aged, Emergency Medicine, Emergency Nursing, Female, Health Care Surveys, Humans, Male, Middle Aged, Nurse-Patient Relations, Patient Satisfaction, Physician-Patient Relations, Prospective Studies, Spain, Telephone, Emergency Service, Hospital, Patients psychology
- Abstract
Objective: To gather specific details about the information, communication, and treatment as regards users of hospital emergency services using a telephone survey, in order to implement improvement measures, if necessary., Methods: A prospective study was conducted in two emergency departments in Salamanca. A total of 400 patients were included in the study (mean age 56.4±20.5years, 58.4% women). A telephone survey was performed with 19 items, of which 12 required responses on a Likert-type scale, with scores of 1 (very bad) to 5 (very good). The remainder of the questions allowed to answer "yes" or "no"., Results: The treatment received by the professionals in general was evaluated positively by 86% of the patients; with 92% reporting they were respectful, 87% were treated by doctors and 71% received treatment from nurses. More than one-quarter (27.5%) did not recall receiving information from blue point staff (personnel specially trained to provide information. Statistical significance (P=.045) was found in relation to the kindness and respect shown by nurses. Most patients that were admitted to the observation area of the emergency department were not informed about the visiting hours (P=.003)., Conclusions: Perception of care received by patients is good, while in relation to information and communication it is evidently improvable, and could be assessed using the survey that is proposed in order to detect and use the weaknesses in these aspects of health care as implementation initiatives., (Copyright © 2014 SECA. Published by Elsevier Espana. All rights reserved.)
- Published
- 2015
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39. Incidence and risk factors for life-threatening bleeding after allogeneic stem cell transplant.
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Labrador J, López-Corral L, Vazquez L, Sánchez-Guijo F, Guerrero C, Sánchez-Barba M, Lozano FS, Alberca I, Del Cañizo MC, Caballero D, and González-Porras JR
- Subjects
- Adult, Aged, Female, Graft vs Host Disease diagnosis, Graft vs Host Disease etiology, Hemorrhage mortality, Humans, Incidence, Male, Middle Aged, Patient Outcome Assessment, Risk Factors, Transplantation Conditioning adverse effects, Transplantation, Homologous, Hematopoietic Stem Cell Transplantation adverse effects, Hemorrhage epidemiology, Hemorrhage etiology
- Abstract
Bleeding is a frequent complication after allogeneic haematopoietic stem cell transplantation (HSCT) and may affect survival. The purpose of this study was to determine the incidence and risk factors for life-threatening bleeding after HSCT by retrospective evaluation of 491 allogeneic HSCT recipients. With a median follow-up of 33 months, 126 out of 491 allogeneic HSCT recipients experienced a haemorrhagic event (25·7%) and 46 patients developed a life-threatening bleeding episode (9·4%). Pulmonary and gastrointestinal bleeding were the most common sites for life-threatening bleeding, followed by central nervous system. In multivariate analyses, the presence of severe thrombocytopenia after day +28 and the development of grade III-IV acute graft-versus-host disease (GVHD) or thrombotic microangiopathy (TMA) retained their association with life-threatening bleeding events. The overall survival at 3 years among patients without bleeding was 67·1% for only 17·1% for patients with life-threatening bleeding (P < 0·001). In conclusion, life-threatening bleeding is a common complication after allogeneic HSCT. Prolonged severe thrombocytopenia, acute grade III-IV GVHD and TMA were associated with its development., (© 2015 John Wiley & Sons Ltd.)
- Published
- 2015
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40. Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms.
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Blanco B, Herrero-Sánchez MC, Rodríguez-Serrano C, Sánchez-Barba M, and Del Cañizo MC
- Subjects
- Adenine analogs & derivatives, Adenine pharmacology, Apoptosis drug effects, Cell Differentiation, Cytokines biosynthesis, Humans, Immunophenotyping, Inhibitory Concentration 50, Isoenzymes, Morpholines pharmacology, Phosphorylation, Proto-Oncogene Proteins c-akt metabolism, Pyrimidinones pharmacology, Quinazolines pharmacology, T-Lymphocytes cytology, T-Lymphocytes metabolism, Class I Phosphatidylinositol 3-Kinases antagonists & inhibitors, Enzyme Inhibitors pharmacology, Lymphocyte Activation drug effects, Lymphocyte Activation immunology, T-Lymphocytes drug effects, T-Lymphocytes immunology
- Abstract
PI3K inhibitors have emerged as potential therapeutic tools for a variety of diseases, and thus, a vast array of compounds with specificity for different PI3K isoforms is being developed. Gaining knowledge about the contribution of the different isoforms to PI3K function will allow selecting the most appropriate inhibitor for each pathology. In this study, we have addressed the effect of PI3K inhibitors with specificity for different class I PI3K isoforms on primary human T cell activation. In particular, we have analyzed proliferation, expression of activation and differentiation markers, apoptosis induction, cytokine secretion and Akt phosphorylation in T cells stimulated in vitro with anti-CD3 and anti-CD28 monoclonal antibodies and cultured with either one of these compounds: p110β-specific inhibitor TGX-221, p110δ-specific inhibitor IC-87114, p110γ inhibitor AS-242525 or pan-class I PI3K inhibitor BKM120. Inhibition of any of the isoforms led to an impairment of T cell activation, mainly of cytokine secretion and granzyme B expression. However, only complete blockade of class I PI3K activity with the pan-class I inhibitor effectively abrogated T cell proliferation. These results indicate that these three p110 isoforms (β, δ and γ) take part in T cell activation, but all of them are dispensable for T cell proliferation.
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- 2015
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41. Immature platelet fraction: a new prognostic marker in acute coronary syndrome.
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López-Jiménez RA, Martín-Herrero F, González-Porras JR, Sánchez-Barba M, Martín-Luengo C, and Pabón-Osuna P
- Subjects
- Aged, Female, Humans, Male, Prognosis, Acute Coronary Syndrome blood, Blood Platelets
- Published
- 2013
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42. Development of a list of look-alike drug names with recommended tall man letters.
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Otero López MJ, Martín Muñoz R, Sánchez Barba M, Abad Sazatornil R, Andreu Crespo A, Arteta Jiménez M, Bermejo Vicedo T, and Cajaraville Ordoñana G
- Subjects
- Humans, Drug Labeling methods, Drug Labeling standards, Medication Errors prevention & control
- Abstract
Objective: To develop a list of look-alike drug names with tall man letters, which will facilitate and standardize the implementation of this technique in safety practices designed to reduce errors caused by look-alike names., Material and Methods: Two structured surveys were carried out. The first survey included 46 pairs, groups, or individual look-alike drug names with tall man letters from the lists established by the FDA, ISMP and CAPCA/ISMP-Canada, and 32 selected from ISMP-Spain and the COF Council database. The second survey included 27 proposals made by those respondents who completed the first survey and 11 from the ISMP updated list. Participants were asked about the usefulness and current implementation of the technique. Ninety pharmacists from different hospitals participated in the first survey and 89 in the second., Results: The list of look-alike drug names with tall man letters which has been developed includes 107 names structured into 44 pairs or groups. Of the respondents, 93.3% felt that this technique should be implemented for identifying medications, not only on pharmaceutical industry labels (91.1%) but also in other places where drug names appear, such as computerized prescription screens (90%), pharmacy system screens (82.2%), automated dispensing cabinet screens (81.1%), labels for pharmacy preparations and shelves, etc. Only 9 hospitals (10%) were using this technique., Conclusions: The availability of this list of look-alike drug names for which tall man lettering is recommended may encourage the use of this technique for differentiating names in Spain where it is currently not greatly used., (Copyright © 2011 SEFH. Published by Elsevier Espana. All rights reserved.)
- Published
- 2011
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43. [Patients with clinical criteria for Lynch syndrome with and without mutations in DNA repair genes (MLH1 and MSH2). A challenge for the clinician].
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Seijas Tamayo R, Martín Gómez T, Pérez García J, Macías Álvarez L, Sánchez Barba M, Castro Marcos E, Sánchez Tapia EM, González Sarmiento R, and Cruz Hernández JJ
- Subjects
- Adenocarcinoma diagnosis, Adenocarcinoma genetics, Age of Onset, Aged, Colorectal Neoplasms, Hereditary Nonpolyposis classification, Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Cross-Sectional Studies, Endometrial Neoplasms epidemiology, Endometrial Neoplasms genetics, Female, Genetic Counseling, Humans, Male, Middle Aged, MutL Protein Homolog 1, Phenotype, Retrospective Studies, Spain epidemiology, Adaptor Proteins, Signal Transducing genetics, Adenocarcinoma epidemiology, Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology, DNA Repair genetics, Genetic Heterogeneity, MutS Homolog 2 Protein genetics, Mutation, Nuclear Proteins genetics
- Abstract
Background and Objectives: The objective was to study the clinicopathologic characteristics of patients diagnosed of colorectal cancer (CRC) with clinical criteria for Lynch syndrome, in our region, in order to assess and improve the care of them and their families in the Genetic Counseling Unit of our hospital., Patients and Methods: This was an observational, transversal retrospective study. The studied sample was made up of all the patients with clinical criteria for Lynch syndrome, who underwent a molecular analysis test in the Genetic Counseling Unit of Salamanca, during the period 2004-2009. We included patient and tumor related variables and the presence or absence of mutations in MLH1 and MSH2., Results: A total of 76 patients were included in the analysis. Fifteen of them carried a mutation either in MLH1 or in MSH2. The mean age at diagnosis of colorectal cancer was 51.2 and 54.3 years in the group with and without mutation respectively, with a similar gender distribution in both groups. A wide phenotypic heterogeneity was found in the sample., Conclusions: Lynch syndrome is an entity difficult to categorize from a clinical point of view. Therefore, it is important to be alert for a better management of these patients and their families., (Copyright © 2010 Elsevier España, S.L. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
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