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1. PTAL multi-spectral database of planetary terrestrial analogues: Raman data overview

Author

Veneranda, Marco, Saiz, Jesus, Sanz-Arranz, Aurelio, Manrique, Jose Antonio, Lopez-Reyes, Guillermo, Medina, Jesus, Dypvik, Henning, Werner, Stephanie C., and Rull, Fernando

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Condensed Matter - Materials Science
Abstract

The multi analytical study of terrestrial analogues is a useful strategy to deepen the knowledge about the geological and environmental evolution of Mars and other extraterrestrial bodies. In spite of the increasing importance that LIBS, NIR and Raman techniques are acquiring in the field of space exploration, there is a lack web-based platform providing free access to a wide multi-spectral database of terrestrial analogue materials. The Planetary Terrestrial Analogue Library (PTAL) project aims at responding to this critical need by developing and providing free web accessibility to LIBS, NIR and Raman data from more than 94 terrestrial analogues selected according to their congruence with Martian geological contexts. In this framework, the present manuscript provides the scientific community with a complete overview of the over 4500 Raman spectra collected to feed the PTAL database. Raman data, obtained through the complementary use of laboratory and spacecraft-simulator systems, confirmed the effectiveness of this spectroscopic technique for the detection of major and minor mineralogical phases of the samples, the latter being of critical importance for the recognition of geological processes that could have occurred on Mars and other planets. In light of the forthcoming missions to Mars, the results obtained through the RLS ExoMars Simulator offer a valuable insight on the scientific outcome that could derive from the RLS spectrometer that will soon land on Mars as part of the ExoMars rover payload.

Published
2021
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5. Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Author

Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, Rivera, José M., Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., and Suárez Fernández, C.

Published
2018
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6. Factores asociados al mal control de la anticoagulación con antivitamina K en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author

Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, Rivera., José M., Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., and Suárez Fernández, C.

Published
2018
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8. Involvement of nucleic-acid methylation on biology and evolution: from first hominids to modern humans -- Review.

Author

Dorado, Gabriel, Luque, Fernando, Esteban, Francisco José, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Subjects
BIOLOGICAL evolution, HOMINIDS, MOLECULAR biology, DEVELOPMENTAL biology, NUCLEIC acids, FOSSIL DNA, RNA methylation, METHYLATION
Abstract

Copyright of Archaeobios is the property of Arqueobios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

11. Implications of non-coding RNA on biology and evolution: from first hominids to modern humans

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., Hernández Molina, Pilar, Ministerio de Economía y Competitividad (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Junta de Andalucía, and Universidad de Córdoba (España)

Subjects
TGS, next- generation sequencing, Ancient RNA, aRNA, NGS, SGS, Third-generation sequencing, Second-generation sequencing
Abstract

[EN] Massive genomic/transcriptomic sequencing has revealed a shocking paradox: pervasive or spurious transcription. Although such event is unwanted in principle, some of such transcripts may scape degradation, being further selected by evolution, with fascinating consequences on biology, including our brain development and what made us humans. Indeed, non-coding RNA are involved in many regulatory processes, across the central dogma of molecular biology, and even epigenetics events. Interestingly, that is partially accomplished regulating the expression and function of small RNA, like miRNA. More strikingly, non-coding RNA are involved in neuron physiology and brain neurogenesis, including outgrowth or neuron projections, synaptic functions and translation in synapses. Besides, non- coding RNA can be exported-imported between cells, through exosome vesicles. Surprisingly, some non-coding RNA are indeed translated into micropeptides, which may be involved in brain development. All that allows the remarkable cognitive power of the human brain. Unfortunately, this exquisite development, that made us humans, is specially prone to internal and external perturbations. They may generate neurodevelopmental, neurodegenerative and neuropsychiatric disorders, to which humans are more prone than other primates., [ES] La secuenciación genómica/transcriptómica masiva ha revelado una paradoja impactante: la transcripción generalizada o espuria. Aunque tal evento es no deseado en principio, algunos de tales transcritos pueden escapar de la degradación, siendo seleccionados por la evolución, con consecuencias fascinantes en biología, incluido el desarrollo de nuestro cerebro y lo que nos hizo humanos. De hecho, los ARN no codificantes están involucrados en muchos procesos reguladores, a través de todo el dogma central de la biología molecular, e incluso en eventos epigenéticos. Curiosamente, ello se logra parcialmente regulando la expresión y la función de ARN pequeños, como los miARN. Más sorprendentemente, los ARN no codificantes están involucrados en la fisiología de las neuronas y la neurogénesis cerebral, incluyendo las excrecencias o proyecciones neuronales, funciones sinápticas y traducción en sinapsis. Además, el ARN no codificante puede exportarse-importarse entre células, a través de vesículas de exosomas. Sorprendentemente, algunos ARN no codificantes se traducen en micropéptidos, que pueden estar involucrados en el desarrollo del cerebro. Todo eso permite el notable poder cognitivo del cerebro humano. Desafortunadamente, este desarrollo exquisito, que nos hizo humanos, es especialmente propenso a perturbaciones internas y externas. Así, pueden generarse trastornos del neurodesarrollo, neurodegenerativos y neuropsiquiátricos, a los cuales los humanos somos más propensos que otros primates., Supported by “Ministerio de Economía y Competitividad” (MINECO grant BIO2015-64737-R) and “Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria” (MINECO and INIA RF2012-00002-C02-02); “Consejería de Agricultura y Pesca” (041/C/2007, 75/C/2009 and 56/C/2010), “Consejería de Economía, Innovación y Ciencia” (P11-AGR-7322 and P12-AGR-0482) and “Grupo PAI” (AGR-248) of “Junta de Andalucía”; and “Universidad de Córdoba” (“Ayuda a Grupos”), Spain.

Published
2020

12. Implications of non-coding RNA on biology and evolution: from first hominids to modern humans

Author

Ministerio de Economía y Competitividad (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Junta de Andalucía, Universidad de Córdoba (España), Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., Hernández Molina, Pilar, Ministerio de Economía y Competitividad (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Junta de Andalucía, Universidad de Córdoba (España), Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández Molina, Pilar

Abstract

[EN] Massive genomic/transcriptomic sequencing has revealed a shocking paradox: pervasive or spurious transcription. Although such event is unwanted in principle, some of such transcripts may scape degradation, being further selected by evolution, with fascinating consequences on biology, including our brain development and what made us humans. Indeed, non-coding RNA are involved in many regulatory processes, across the central dogma of molecular biology, and even epigenetics events. Interestingly, that is partially accomplished regulating the expression and function of small RNA, like miRNA. More strikingly, non-coding RNA are involved in neuron physiology and brain neurogenesis, including outgrowth or neuron projections, synaptic functions and translation in synapses. Besides, non- coding RNA can be exported-imported between cells, through exosome vesicles. Surprisingly, some non-coding RNA are indeed translated into micropeptides, which may be involved in brain development. All that allows the remarkable cognitive power of the human brain. Unfortunately, this exquisite development, that made us humans, is specially prone to internal and external perturbations. They may generate neurodevelopmental, neurodegenerative and neuropsychiatric disorders, to which humans are more prone than other primates., [ES] La secuenciación genómica/transcriptómica masiva ha revelado una paradoja impactante: la transcripción generalizada o espuria. Aunque tal evento es no deseado en principio, algunos de tales transcritos pueden escapar de la degradación, siendo seleccionados por la evolución, con consecuencias fascinantes en biología, incluido el desarrollo de nuestro cerebro y lo que nos hizo humanos. De hecho, los ARN no codificantes están involucrados en muchos procesos reguladores, a través de todo el dogma central de la biología molecular, e incluso en eventos epigenéticos. Curiosamente, ello se logra parcialmente regulando la expresión y la función de ARN pequeños, como los miARN. Más sorprendentemente, los ARN no codificantes están involucrados en la fisiología de las neuronas y la neurogénesis cerebral, incluyendo las excrecencias o proyecciones neuronales, funciones sinápticas y traducción en sinapsis. Además, el ARN no codificante puede exportarse-importarse entre células, a través de vesículas de exosomas. Sorprendentemente, algunos ARN no codificantes se traducen en micropéptidos, que pueden estar involucrados en el desarrollo del cerebro. Todo eso permite el notable poder cognitivo del cerebro humano. Desafortunadamente, este desarrollo exquisito, que nos hizo humanos, es especialmente propenso a perturbaciones internas y externas. Así, pueden generarse trastornos del neurodesarrollo, neurodegenerativos y neuropsiquiátricos, a los cuales los humanos somos más propensos que otros primates.

Published
2020

13. Evaluation of multivariate analyses and data fusion between Raman and laser-induced breakdown spectroscopy in binary mixtures and its potential for solar system exploration

Author

Bozic, Thomas, Manrique, José Antonio, López-Reyes, G., Álvarez-Pérez, A., Veneranda, Marco, Sanz-Arranz, Aurelio, Sáiz, Jesús, Medina, Jesús, Rull, Fernando, Bozic, Thomas, Manrique, José Antonio, López-Reyes, G., Álvarez-Pérez, A., Veneranda, Marco, Sanz-Arranz, Aurelio, Sáiz, Jesús, Medina, Jesús, and Rull, Fernando

Abstract

Raman and laser-induced breakdown spectroscopy (LIBS) spectroscopies will play an important role in planetary exploration missions in the following years, not only with Raman instruments like Raman laser spectrometer on board of Rosalid Franklin Rover or scanning habitable environments with Raman and luminescence for organics and chemicals on board Mars2020 Rover but also with combined instruments such as SuperCam. These techniques will be part of the upcoming planetary exploration missions because they can provide complementary information from the analysed sample while potentially sharing hardware components, maximizing the scientific return of the samples while limiting mass. In this framework, this study seeks to test the feasibility of combining several univariate and multivariate analysis techniques with data fusion techniques of different instruments (532 and 785 nm Raman and LIBS) to evaluate the improvements in the quantitative classification of samples in binary mixtures. We prepared two-component mixtures that are potentially relevant in planetary exploration missions, using two different sulfates and a chloride. A more accurate classification of the samples is possible through a univariate analysis that combines the calculated concentration indicators for Raman and LIBS. On the other hand, multivariate analysis was run on Raman, LIBS, and Raman + LIBS low-level fused data sets. The results showed a better improvement when fusing LIBS and Raman when compared with the redundant fusion but not a systematic improvement when compared with individual sets. We demonstrate that a quantification of the mineral abundances in binary mixtures can be obtained from Raman and LIBS data using univariate and multivariate analysis techniques, being the latter remarkably better, moving from performances of classification, in the whole range of concentrations, that could be over the 10% to values under 3.5%. Furthermore, the fusion of data coming from these techniques impro

Published
2020

14. XXXVII Cátedra extraordinaria S. José de Calasanz : '50 aniversario de Carta a una maestra' y de Lorenzo Milani (Escuela de Barbiana) en el IV Centenario de las Escuelas Pías

Author

Lecea Sáiz, Jesús María

Subjects
profesor, Milani, historia de la educación, Escuela de Barbiana, organización religiosa, Escuelas Pías, Carta a una maestra, desfavorecido social, escuela
Abstract

Resumen basado en el de la publicación Título, resumen y palabras clave en español y en inglés Los PP. Escolapios, patrocinadores de la Cátedra, celebran 400 años de su fundación por San José de Calasanz y los 250 años de la canonización del mismo. El tema central de la Cátedra está referido a D. Lorenzo Milani, Cura y maestro de Barbiana, Italia, en el aniversario de los 50 años de su muerte y de la publicación del libro colectivo (Milani y sus alumnos de Barbiana) de Carta a una maestra. ESP

Published
2018

16. Molecular biology to infer phenotypes of forensic and ancient remains in bioarchaeology -- Review.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Subjects
NEANDERTHALS, PHENOTYPES, MOLECULAR biology, ARTIFICIAL intelligence, FORENSIC anthropology, ARCHAEOLOGICAL human remains, GENOTYPES
Abstract

Copyright of Archaeobios is the property of Arqueobios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021

17. Biología molecular para inferir fenotipos de restos forenses y antiguos en bioarqueología -- Revisión.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Subjects
NEANDERTHALS, ARTIFICIAL intelligence, DNA methylation, NUCLEIC acids, GENOTYPES
Abstract

Copyright of Archaeobios is the property of Arqueobios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021

18. Planetary Terrestrial Analogues Library (PTAL) project: Raman data overview.

Author

Veneranda, Marco, Sáiz, Jesús, Sanz‐Arranz, Aurelio, Manrique, Jose Antonio, Lopez‐Reyes, Guillermo, Medina, Jesús, Dypvik, Henning, Werner, Stephanie C., and Rull, Fernando

Subjects
*LASER-induced breakdown spectroscopy, *MULTISPECTRAL imaging, *RAMAN spectroscopy, *RAMAN lasers, *SPACE exploration, *MARS (Planet)
Abstract

The multianalytical study of terrestrial analogues is a useful strategy to deepen the knowledge about the geological and environmental evolution of Mars and other extraterrestrial bodies. In spite of the increasing importance that laser‐induced breakdown spectroscopy (LIBS), near‐infrared spectroscopy (NIR), and Raman techniques are acquiring in the field of space exploration, there is a lack Web‐based platform providing free access to a wide multispectral database of terrestrial analogue materials. The Planetary Terrestrial Analogues Library (PTAL) project aims at responding to this critical need by developing and providing free Web accessibility to LIBS, NIR, and Raman data from more than 94 terrestrial analogues selected according to their congruence with Martian geological contexts. In this framework, the present manuscript provides the scientific community with a complete overview of the over 4,500 Raman spectra collected to feed the PTAL database. Raman data, obtained through the complementary use of laboratory and spacecraft‐simulator systems, confirmed the effectiveness of this spectroscopic technique for the detection of major and minor mineralogical phases of the samples, the latter being of critical importance for the recognition of geological processes that could have occurred on Mars and other planets. In light of the forthcoming missions to Mars, the results obtained through the Raman Laser Spectrometer (RLS) ExoMars Simulator offer a valuable insight on the scientific outcome that could derive from the RLS spectrometer that will soon land on Mars as part of the ExoMars rover payload. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
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19. Implications of non-coding RNA on biology and evolution: from first hominids to modern humans - Review.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Subjects
NON-coding RNA, BIOLOGICAL evolution, HOMINIDS, NEURAL physiology, MOLECULAR biology, SYNAPSES
Abstract

Copyright of Archaeobios is the property of Arqueobios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

21. Estudio y cuantificación del ahorro energético alcanzado mediante la rehabilitación de un edificio de viviendas representativo del parque residencial de Valencia de los años 60, en el marco del proyecto europeo ELIH-MED

Author

Ruiz Sáiz, Jesús

Subjects
Proyecto europeo ELIH-MED, MECANICA DE LOS MEDIOS CONTINUOS Y TEORIA DE ESTRUCTURAS, Eficiencia energética, Viviendas, Rehabilitation, Máster Universitario en Conservación del Patrimonio Arquitectónico-Màster Universitari en Conservació del Patrimoni Arquitectònic, 20th century, Energy efficiency, Rehabilitación, Housing, ELIH-MED, Valencia, Siglo XX
Abstract

Comprobación de los resultados obtenidos en la rehabilitación energética realizada en un edificio tipo de los años 70 de Valencia, dentro del proyecto europeo ELIH-MED. Se realiza una monitorización de parte de las viviendas mediante Smart-Meters y una vez realizada la obra, un año después se comparan los resultados obtenidos por las evaluaciones energéticas del programa CERMA son las lecturas de la monitorización y las facturas de las compañías suministradoras para ver la posible desviación., Checking of the results obtained in the energetic rehabilitation realized in a building type of the 70s of Valencia, inside the European project ELIH-MED. A monitoring is realized on behalf of the housings by means of Smart-Meters and once realized the work, one year later there are compared the results obtained by the energetic evaluations of the program CERMA are the readings of the monitoring and the invoices of the energy companies to see the possible diversion.

Published
2016

22. Second-generation nucleic-acid sequencing and bioarchaeology - Review

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Pérez-Jiménez, Margarita, Raya, Patricia, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., Hernández Molina, Pilar, Ministerio de Economía y Competitividad (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Junta de Andalucía, and Universidad de Córdoba (España)

Subjects
High-throughput sequencing (HTS), Ancient DNA, Paleogenomes, Paleoenvironmental DNA (PalEnDNA), Polymerase chain-reaction (PCR)
Abstract

The nucleic-acid revolution started 31 years ago. The development of the second-generation sequencing (SGS) has allowed a higher throughput and lower price per sequenced base, opening the possibility to sequence ancient genomes, including epigenetics. The main SGS platforms are described in this review: i) Roche 454 Life Sciences, based on emulsion PCR (emPCR) and further pyrosequencing; ii) Illumina (bridge-amplification and subsequent reversible-terminator sequencing); iii) Life Technologies SOLiD (emPCR coupled with oligonucleotide ligation to interrogate DNA); and iv) Life Technologies Ion-Torrent-chip (emPCR, further using microchip pH-meters). Different ancient genomes (including viruses, microorganisms, plants and animals) have been sequenced. This has allowed to study the evolution of pathogens, domestication of microorganisms, plants and animals, paleodiets and paleoenvironments, including climate changes. Some hurdles and challenges must yet be overcome, but the steady technological advances in nucleic-acid isolation, sequencing and bioinformatics (together with higher computing power) promise a bright future for bioarchaeology in general, and paleogenomics in particular, allowing to analyze not just single genomes, but also to address ancient population genomics and evolution., Supported by “Ministerio de Economía y Competitividad” (MINECO grants AGL2010-17316 and BIO2011-15237-E) and “Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria” (MINECO and INIA RF2012-00002-C02-02); “Consejería de Agricultura y Pesca” (041/C/2007, 75/C/2009 and 56/C/2010), “Consejería de Economía, Innovación y Ciencia” (P11-AGR-7322 and P12-AGR-0482) and “Grupo PAI” (AGR-248) of “Junta de Andalucía”; and “Universidad de Córdoba” (“Ayuda a Grupos”), Spain.

Published
2015

23. Bioarqueología para recuperar aromas de plantas extintas - Revisión.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Subjects
MOLECULAR biology, CLASSICAL antiquities, NUCLEIC acids, MOLECULAR cloning, ODORS, SYNTHETIC biology
Abstract

Copyright of Archaeobios is the property of Arqueobios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019

24. Bioarchaeology to bring back scents from extinct plants - Review.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Subjects
MOLECULAR biology, CLASSICAL antiquities, NUCLEIC acids, MOLECULAR cloning, ODORS, SYNTHETIC biology
Abstract

Copyright of Archaeobios is the property of Arqueobios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019

25. Estudio y cuantificación del ahorro energético alcanzado mediante la rehabilitación de un edificio de viviendas representativo del parque residencial de Valencia de los años 60, en el marco del proyecto europeo ELIH-MED

Author

Serrano Lanzarote, Apolonia Begoña, Moreno Puchalt, Jésica, Ortega Madrigal, Leticia, Ruiz Sáiz, Jesús, Serrano Lanzarote, Apolonia Begoña, Moreno Puchalt, Jésica, Ortega Madrigal, Leticia, and Ruiz Sáiz, Jesús

Abstract

Comprobación de los resultados obtenidos en la rehabilitación energética realizada en un edificio tipo de los años 70 de Valencia, dentro del proyecto europeo ELIH-MED. Se realiza una monitorización de parte de las viviendas mediante Smart-Meters y una vez realizada la obra, un año después se comparan los resultados obtenidos por las evaluaciones energéticas del programa CERMA son las lecturas de la monitorización y las facturas de las compañías suministradoras para ver la posible desviación., Checking of the results obtained in the energetic rehabilitation realized in a building type of the 70s of Valencia, inside the European project ELIH-MED. A monitoring is realized on behalf of the housings by means of Smart-Meters and once realized the work, one year later there are compared the results obtained by the energetic evaluations of the program CERMA are the readings of the monitoring and the invoices of the energy companies to see the possible diversion.

Published
2016

26. Second-generation nucleic-acid sequencing and bioarchaeology - Review

Author

Ministerio de Economía y Competitividad (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Junta de Andalucía, Universidad de Córdoba (España), Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Pérez-Jiménez, Margarita, Raya, Patricia, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., Hernández Molina, Pilar, Ministerio de Economía y Competitividad (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Junta de Andalucía, Universidad de Córdoba (España), Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Pérez-Jiménez, Margarita, Raya, Patricia, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández Molina, Pilar

Abstract

The nucleic-acid revolution started 31 years ago. The development of the second-generation sequencing (SGS) has allowed a higher throughput and lower price per sequenced base, opening the possibility to sequence ancient genomes, including epigenetics. The main SGS platforms are described in this review: i) Roche 454 Life Sciences, based on emulsion PCR (emPCR) and further pyrosequencing; ii) Illumina (bridge-amplification and subsequent reversible-terminator sequencing); iii) Life Technologies SOLiD (emPCR coupled with oligonucleotide ligation to interrogate DNA); and iv) Life Technologies Ion-Torrent-chip (emPCR, further using microchip pH-meters). Different ancient genomes (including viruses, microorganisms, plants and animals) have been sequenced. This has allowed to study the evolution of pathogens, domestication of microorganisms, plants and animals, paleodiets and paleoenvironments, including climate changes. Some hurdles and challenges must yet be overcome, but the steady technological advances in nucleic-acid isolation, sequencing and bioinformatics (together with higher computing power) promise a bright future for bioarchaeology in general, and paleogenomics in particular, allowing to analyze not just single genomes, but also to address ancient population genomics and evolution.

Published
2015

27. Influencia de las cubiertas en el estado energético de un edificio existente y su viabilidad económica

Author

Ruiz Sáiz, Jesús

Subjects
Máster en Edificación especialidad Tecnología de la Edificación-Màster en Edificació Especialitat Tecnologia de l'Edificació, Cubiertas (Construcción), Análisis económico, Arquitectura y clima, Eficiencia energética, Arquitectura sostenible, MAQUINAS Y MOTORES TERMICOS, Análisis coste-beneficio, Edificios para la enseñanza, TERMODINAMICA APLICADA (UPV)
Abstract

El objetivo del trabajo es analizar un edificio existente y estudiar las repercusiones de un cambio de tipología de cubierta: incidencia en su calificación energética, coste, viabilidad económica, etc. La finalidad no es reducir el consumo energético a cualquier coste, sino que se persigue también que la inversión sea amortizable con el ahorro conseguido. Por otra parte, dado que a menor altura mayor es la repercusión de la cubierta en la termodinámica del inmueble, se selecciona para su estudio un edificio de pocas alturas, la Escuela Oficial de Idiomas de Gandía. El trabajo experimental ha consistido en analizar el edificio con los programas existentes para la calificación energética (LIDER y CALENER). En primer lugar se realizan los cálculos con los datos obtenidos "in situ", y después se realizan varias propuestas en las que se lleva a cabo un cambio de cubierta con el fin de ver que ahorro supone, sus costes y si son amortizables o no. Para terminar se analizan todos los resultados para hacer una propuesta, a modo de guía de intervención, en la que se detallan los pasos a seguir en edificios constructivamente similares al analizado.

Published
2013

28. Evolución desde los primeros homínidos a los humanos modernos: filosofía, bioarqueología y biología - Revisión.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Abstract

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Published
2018

29. Evolution from first hominids to modern humans: philosophy, bioarchaeology and biology - Review.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Subjects
EVOLUTIONARY theories, HOMINIDS, HUMAN evolution
Abstract

Copyright of Archaeobios is the property of Arqueobios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018

30. Clustered Regularly-Interspaced Short-Palindromic Repeats (CRISPR) in bioarchaeology - Review.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., and Vásquez, Víctor F.

Abstract

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Published
2017

31. Sequencing ancient RNA in bioarchaeology - Review.

Author

Dorado, Gabriel, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Pérez-Jiménez, Margarita, Raya, Patricia, Sáiz, Jesús, Sánchez, Adela, Martín, Jesús, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Abstract

Copyright of Archaeobios is the property of Arqueobios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016

32. Influencia de las cubiertas en el estado energético de un edificio existente y su viabilidad económica

Author

García Laespada, Antonio, Universitat Politècnica de València. Escuela Técnica Superior de Gestión en la Edificación - Escola Tècnica Superior de Gestió en l'Edificació, Ruiz Sáiz, Jesús, García Laespada, Antonio, Universitat Politècnica de València. Escuela Técnica Superior de Gestión en la Edificación - Escola Tècnica Superior de Gestió en l'Edificació, and Ruiz Sáiz, Jesús

Abstract

El objetivo del trabajo es analizar un edificio existente y estudiar las repercusiones de un cambio de tipología de cubierta: incidencia en su calificación energética, coste, viabilidad económica, etc. La finalidad no es reducir el consumo energético a cualquier coste, sino que se persigue también que la inversión sea amortizable con el ahorro conseguido. Por otra parte, dado que a menor altura mayor es la repercusión de la cubierta en la termodinámica del inmueble, se selecciona para su estudio un edificio de pocas alturas, la Escuela Oficial de Idiomas de Gandía. El trabajo experimental ha consistido en analizar el edificio con los programas existentes para la calificación energética (LIDER y CALENER). En primer lugar se realizan los cálculos con los datos obtenidos "in situ", y después se realizan varias propuestas en las que se lleva a cabo un cambio de cubierta con el fin de ver que ahorro supone, sus costes y si son amortizables o no. Para terminar se analizan todos los resultados para hacer una propuesta, a modo de guía de intervención, en la que se detallan los pasos a seguir en edificios constructivamente similares al analizado.

Published
2013

33. Secuenciación de ácidos nucleicos de segunda generación y bioarqueología - Revisión.

Author

Dorado, Gabriel, Pérez-Jiménez, Margarita, Vásquez, Víctor F., Hernández, Pilar, Luque, Fernando, Pascual, Plácido, Jiménez, Inmaculada, Sánchez-Cañete, Francisco Javier S., Raya, Patricia, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, and Rosales, Teresa E.

Abstract

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Published
2015

34. Genómica del almidón y bioarqueología - Revisión.

Author

Dorado, Gabriel, Margarita Pérez-Jiménez, Plácido Pascual, Vásquez, Víctor F., Hernández, Pilar, Sánchez-Cañete, Francisco Javier S., Pascual, Plácido, Jiménez, Inmaculada, Luque, Fernando, Raya, Patricia, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, and Rosales, Teresa E.

Abstract

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Published
2014

35. Starch genomics and bioarchaeology - Review.

Author

Dorado, Gabriel, Pérez-Jiménez, Margarita, Hernández, Pilar, Sánchez-Cañete, Francisco Javier S., Pascual, Plácido, Jiménez, Inmaculada, Luque, Fernando, Raya, Patricia, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., and Vásquez, Víctor F.

Subjects
ZOOARCHAEOLOGY, GENOMICS, STARCH
Abstract

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Published
2014

36. Colaboradores

Author

Abad-Santos, Francisco, Abizanda, Pedro, Adín, Javier, Antonio Amado, José, Maria Aran, Josep, Antonio Armijo, Juan, Avendaño, Cristina, Javier Ayesta, F., Ramón Azanza, José, Badia, Albert, Manuel Baeyens, José, Baños, Josep-Eladi, Dolores Barrachina, María, Nicolás Boada, José, Calvo, Soledad, Castro, Elena, Ceña, Valentín, Cortijo, Julio, de Cos, M.ª Ángeles, del Arco<ce:sup loc='post">†</ce:sup>, Carmen, del Río, Joaquín, Delpón, Eva, Díaz, Álvaro, Echevarría, Santiago, Vicente Esplugues, Juan, Feria, Manuel, Flórez, Jesús, Flórez, José C., Dolores Galán, María, Galindo, María F., García, Antonio G., García-Lobo, Juan M.ª, García-Sevilla, Jesús A., González-García, Carmen, González-Macías, Jesús, González-Ruiz, Mario, Luis Herranz, José, Amor Hurlé, María, Jordán, Joaquín, López-Vega, José M., Martí Cabrera, Miguel, Martínez-Cué, Carmen, Javier Meana, J., Mediavilla, África, Merino, Jesús, Monti, Jaime, Morcillo, Esteban, Ochoa, Dolores, Pascual, Julio, Pazos, Ángel, Peralta, Galo, Posadas, Inmaculada, Rodríguez, Miriam, Sádaba, Belén, Saiz, Jesús, Sallés, Joan, Sánchez García, Adela, Blanca Sánchez, María, Santamaría, Javier, Jesús Sanz, María, del Carmen Sedano, María, Tamargo, Juan, Valdizán, Elsa M., and Villar, Ana V.

Published
2014
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37. Genomics and proteomics in bioarchaeology - Review.

Author

Dorado, Gabriel, Jiménez, Inmaculada, Rey, Isabel, Sánchez-Cañete, Francisco Javier S., Luque, Fernando, Morales, Arturo, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, Rosales, Teresa E., Vásquez, Víctor F., and Hernández, Pilar

Subjects
GENETIC research, TECHNOLOGICAL innovations, GENETIC genealogy, PALEONTOLOGY, PALEOBIOLOGY, PALEOECOLOGY, ZOOARCHAEOLOGY, PALEOBOTANY
Abstract

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Published
2013

38. Isotopes in bioarchaeology - Review.

Author

Dorado, Gabriel, Rosales, Teresa E., Luque, Fernando, Sánchez-Cañete, Francisco Javier S., Rey, Isabel, Jiménez, Inmaculada, Morales, Arturo, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, Vásquez, Víctor F., and Hernández, Pilar

Subjects
CHEMICAL elements, PERIODIC table of the elements, ATOMIC number, NUCLIDES, MASS spectrometry, PALEOECOLOGY
Abstract

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Published
2012

39. Ancient nucleic acids from maize - A review.

Author

Dorado, Gabriel, Rosales, Teresa, Luque, Fernando, Sánchez-Cañete, Francisco Javier S., Rey, Isabel, Jiménez, Inmaculada, Morales, Arturo, Gálvez, Manuel, Sáiz, Jesús, Sánchez, Adela, Vásquez, Víctor F., and Hernández, Pilar

Subjects
CORN, PLANT genetics, PLANT genomes, GRAIN, MOLECULAR biology
Abstract

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Published
2011

42. Altered Renal αAdrenoceptor Density Induced by Prolonged NaCl and DOCA Administration in Spontaneously Hypertensive Rats

Author

Sánchez, Adela, Lara, Baldomero, and Sáiz, Jesús

Abstract

This study examines the effects of a 6-week exposure to 1 NaCl in tap water with and without desoxycorticosterone acetate (DOCA) on renal a adrenoceptors and systolic blood pressure (SBP) in spontaneously hypertensive adult rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. On normal sodium intake, SHR had higher renal α1- (p < 0.05) and α2-adrenoceptor densities (p < 0.001) and SBP (p < 0.001) than WKY rats. Although WKY rats given either 1 NaCl, DOCA, or DOCA plus 1 NaCl developed hypertension after 6 weeks of treatment, only 1 NaCl administration for the same period produced an increase in the α1-adrenoceptor density when compared to the control (p < 0.001). In SHR, ingestion of 1 NaCl or DOCA plus 1 NaCl increased the already elevated α2-adrenoceptor density (p < 0.001) and SBP even more in this strain after 6 weeks of treatment. Equilibrium dissociation constants (Kd), however, were similar for both classes of receptors in experimental and control rats. The results of this study indicate that only the combination of 1 NaCl in tap water and DOCA administration is effective in accelerating hypertension in adult SHR. On the other hand, in this form of genetic rat hypertension, exaggerated sodium intake with or without DOCA administration could presumably be correlated with the increased renal α2adrenoceptors observed in these animals.

Published
1990

46. Platelet α2adrenoceptor density in pregnancyinduced hypertensive patients

Author

Sánchez, Adela, Sáiz, Jesús, Sáez, Basilio, Carrasco, Santiago, and Diaz, Ramon

Abstract

Although pregnancy induced hypertension (PIH) is an important and relatively common medical problem, its pathophysiology remains unresolved and the search for a biochemical marker that precedes the hemodynamic abnormalities of PIH continues. Since human platelets contain α2-adrenoceptors, these receptors were measured in women with PIH to determine whether patients with PIH have α2-adrenoceptor abnormalities that might cause or exacerbate the hypertensive process. The effect of epidural analgesia upon blood pressure and its relation to changes in platelet α2-adrenoceptor density were also investigated.

Published
1992

47. Yohimbine-induced alterations in alpha(2)-adrenoceptors in kidney regions of the spontaneously hypertensive rats: an autoradiographic analysis.

Author

Sáiz J, Pazos A, Del Olmo E, Sáiz V, and Sánchez A

Subjects
Adrenergic alpha-2 Receptor Agonists, Adrenergic alpha-2 Receptor Antagonists, Adrenergic alpha-Antagonists pharmacology, Analysis of Variance, Animals, Autoradiography methods, Benzazepines pharmacology, Blood Pressure drug effects, Brimonidine Tartrate, Clonidine pharmacology, Heart Rate drug effects, Kidney Cortex metabolism, Kidney Medulla drug effects, Kidney Medulla metabolism, Male, Quinoxalines pharmacology, Rats, Rats, Inbred SHR, Rats, Inbred WKY, Tritium, Hypertension physiopathology, Kidney Cortex drug effects, Receptors, Adrenergic, alpha-2 metabolism, Yohimbine pharmacology
Abstract

We have tested the hypothesis that a pharmacologically determined alteration in renal alpha(2)-adrenoceptor (alpha(2)-AR) density might be a pathophysiologically important factor of genetic hypertension in the spontaneously hypertensive rats (SHRs). First, we compared he regional distribution and biochemical parameters of alpha(2)-ARs in SHRs and Wistar-Kyoto (WKY) rats, using the full agonist [(3)H]UK 14304. Secondly, we evaluated the effect of selective blockade and stimulation of alpha(2)-ARs on the development of hypertension and on renal alpha(2)-AR density and regional distribution in SHRs. [(3)H]UK 14304 binding was distributed predominantly over the outer medulla, less abundantly over the inner medulla and was almost absent from the renal cortex. Renal alpha(2)-ARs were found to be increased in SHRs at the ages tested compared with their respective controls and the increase was completely localized to the outer medulla. In these rats, blood pressures immediately before sacrifice were significantly higher in the hypertensive group compared with normotensive controls. The daily administration of SK&F 86,466 or clonidine significantly decreased the blood pressure but the autoradiographic studies showed that the prolonged administration of yohimbine to rats for two weeks resulted in a large increase in the density of alpha(2)-ARs in some areas of the rat kidney but not in others. Taken together these data do not support the hypothesis that alteration in renal alpha(2)-ARs (as measured by autoradiography) is crucial for the maintenance of hypertension in the SHR model.

Published
2008

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