1. Bone Mass and Bone Metabolism Markers during Adolescence: The HELENA Study
- Author
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Gracia Marco, L., Vicente Rodríguez, G., Valtueña, J., Rey López, J. P., Díaz Martínez, A. E., Mesana, M. I., Widhalm, K., Ruiz, J. R., González Gross, M., Castillo, M. J., Moreno, L. A., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Mae L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira J, Bueno G, Lázaro A, Bueno O, Léon JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marco LA, Marcos A, Wärnberg J, Nova E, Gómez S, Daíz EL, Romeo J, Veses A, Puergollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Garzón MJ, Sáinz AG, Porcel FB, Ruiz JR, Artero EG, Romero VE, Pavón DJ, Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrí L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallströöm L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Frederiksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Jiménez Pavón D, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Lorente J.J., VITAGLIONE, PAOLA, Gracia Marco, L., Vicente Rodríguez, G., Valtueña, J., Rey López, J. P., Díaz Martínez, A. E., Mesana, M. I., Widhalm, K., Ruiz, J. R., González Gross, M., Castillo, M. J., Moreno, L. A., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Mae, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, J, Bueno, G, Lázaro, A, Bueno, O, Léon, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marco, La, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Daíz, El, Romeo, J, Veses, A, Puergollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Garzón, Mj, Sáinz, Ag, Porcel, Fb, Ruiz, Jr, Artero, Eg, Romero, Ve, Pavón, Dj, Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrí, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallströöm, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Frederiksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Jiménez Pavón, D, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Lorente, J. J.
- Subjects
Male ,musculoskeletal diseases ,Aging ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Osteocalcin ,chemistry.chemical_element ,Growth ,Calcium ,Bone and Bones ,Collagen Type I ,Bone remodeling ,Absorptiometry, Photon ,Endocrinology ,Internal medicine ,medicine ,Humans ,Bone Resorption ,Sex Characteristics ,β-Isomerized C-telopeptide ,Bone Development ,Anthropometry ,biology ,business.industry ,musculoskeletal, neural, and ocular physiology ,Puberty ,Biomarker ,Organ Size ,Sex Characteristic ,musculoskeletal system ,Calcium, Dietary ,chemistry ,Propeptide of type I procollagen ,Pediatrics, Perinatology and Child Health ,Body Composition ,biology.protein ,Bone mineral content ,Female ,business ,Biomarkers ,Bone and Bone ,Human ,Sex characteristics ,Bone mass - Abstract
Background/Aims: The assessment of bone mineral content (BMC) and density (BMD) status in children and adolescents is important for health and the prevention of diseases. Bone metabolic activity could provide early information on bone mass development. Our aim was to describe bone mass and metabolism markers according to age and Tanner stage in adolescents. Methods: Spanish adolescents (n = 345; 168 males and 177 females) aged 12.5–17.5 years participated in this cross-sectional study. Body composition variables were measured by dual-energy X-ray absorptiometry. Serum osteocalcin (n = 101), aminoterminal propeptide of type I procollagen (n = 92) and β-isomerized C-telopeptides (β-CTX, n = 65) and urine samples (β-CTX; n = 237) were analyzed by electrochemiluminescence immunoassay. Results: Analysis of covariance showed that females had higher values for BMC and BMD in most of the regions. Both males and females had a significant decrease in bone markers while sexual maturation increases (all p < 0.05). Males had an increased bone turnover compared to females (all p < 0.05, except for urine β-CTX in Tanner ≤IV). Conclusion: Our results support the evidence of dimorphic site-specific bone accretion between sexes and show an increased bone turnover in males, suggesting higher metabolic activity.
- Published
- 2010
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