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1. Evaluating stability of attenuated Sabin and two novel type 2 oral poliovirus vaccines in children

Author

Wahid, Rahnuma, Mercer, Laina, Gast, Chris, De Leon, Tirza, Sáez-Llorens, Xavier, Fix, Alan, Macadam, Andrew, Stephens, Laura, Chumakov, Konstantin, Smits, Saskia L, Murreddu, Marta, Konopka-Anstadt, Jennifer L, Steven Oberste, M, Burns, Cara C, Andino, Raul, Bachtiar, Novilia Sjafri, Tritama, Erman, Bandyopadhyay, Ananda S, Aguirre, Gabriela, Rüttimann, Ricardo, and Konz, John O

Subjects
Vaccine Related, Immunization, Prevention, Infectious Diseases, 2.1 Biological and endogenous factors, 3.4 Vaccines, Prevention of disease and conditions, and promotion of well-being, Aetiology, Infection, Good Health and Well Being
Abstract

Novel oral poliovirus vaccine type 2 (nOPV2) is being developed to reduce the rare occurrence of disease and outbreaks associated with the genetic instability of the Sabin vaccine strains. Children aged 1 to 5 years were enrolled in two related clinical studies to assess safety, immunogenicity, shedding rates and properties of the shed virus following vaccination with nOPV2 (two candidates) versus traditional Sabin OPV type 2 (mOPV2). The anticipated pattern of reversion and increased virulence was observed for shed Sabin-2 virus, as assessed using a mouse model of poliovirus neurovirulence. In contrast, there were significantly reduced odds of mouse paralysis for shed virus for both nOPV2 candidates when compared to shed Sabin-2 virus. Next-generation sequencing of shed viral genomes was consistent with and further supportive of the observed neurovirulence associated with shed Sabin-2 virus, as well as the reduced reversion to virulence of shed candidate viruses. While shed Sabin-2 showed anticipated A481G reversion in the primary attenuation site in domain V in the 5' untranslated region to be associated with increased mouse paralysis, the stabilized domain V in the candidate viruses did not show polymorphisms consistent with reversion to neurovirulence. The available data from a key target age group for outbreak response confirm the superior genetic and phenotypic stability of shed nOPV2 strains compared to shed Sabin-2 and suggest that nOPV2 should be associated with less paralytic disease and potentially a lower risk of seeding new outbreaks.

Published
2022

2. Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003): 4·5-year results from a phase 3, randomised, double-blind, placebo-controlled trial

Author

Tricou, Vianney, Yu, Delia, Reynales, Humberto, Biswal, Shibadas, Saez-Llorens, Xavier, Sirivichayakul, Chukiat, Lopez, Pio, Borja-Tabora, Charissa, Bravo, Lulu, Kosalaraksa, Pope, Vargas, Luis Martinez, Alera, Maria Theresa, Rivera, Luis, Watanaveeradej, Veerachai, Dietze, Reynaldo, Fernando, LakKumar, Wickramasinghe, V Pujitha, Moreira, Edson Duarte, Jr, Fernando, Asvini D, Gunasekera, Dulanie, Luz, Kleber, Oliveira, Ana Lucia, Tuboi, Suely, Escudero, Ian, Hutagalung, Yanee, Lloyd, Eric, Rauscher, Martina, Zent, Olaf, Folschweiller, Nicolas, LeFevre, Inge, Espinoza, Felix, and Wallace, Derek

Published
2024
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3. Persistence of protective anti-poliovirus antibody levels in 4-year-old children previously primed with Picovax®, a trivalent, aluminium-adjuvanted reduced dose inactivated polio vaccine

Author

Sáez-Llorens, Xavier, Chan, Milagros, DeAntonio, Rodrigo, Petersen, Torben, Olesen, Charlotte, Jensen, Jens Søndergaard, Sørensen, Charlotte, Ekstrand, Lena Messerschmidt, Czort, Michaela Katrine, Kristensen, Hans-Henrik, Thulstrup, Niels, and Christoffersen, Dorte Birk

Published
2022
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4. Safety and immunogenicity of mRNA-LNP COVID-19 vaccine CVnCoV in Latin American adults: A phase 2 randomized study

Author

Sáez-Llorens, Xavier, Lanata, Claudio, Aranguren, Elaine, Celis, Carlos R., Cornejo, Rubelio, DeAntonio, Rodrigo, Ecker, Lucie, Garrido, Diegi, Gil, Ana I., Gonzales, Marina, Hess-Holtz, Morgan, Leroux-Roels, Geert, Junker, Helga, Kays, Sarah-Katharina, Koch, Sven D., Lazzaro, Sandra, Mann, Philipp, Quintini, Gianluca, Srivastava, Barkha, Vahrenhorst, Dominik, von Eisenhart-Rothe, Philipp, Wolz, Olaf-Oliver, and Oostvogels, Lidia

Published
2022
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5. Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Author

Lovesio, Luciano, Diez, Fabián, Grazziani, Franco, Ganaha, Maria Cristina, Zalatnik, Viviana Judith, Dittrich, Ricardo Julio, Espínola, Lidia, Lambert, Sandra, Longhi, Andrea, Vecchio, Claudia, Mastruzzo, María, Fernandez, Alberto, Borchowiek, Silvina, Potito, Roberto, Ahuad Guerrero, Rodolfo Andres, Guardiani, Fernando Martin, Castella, Sofia, Foccoli, Monica, Pedernera, Aldana, Braida, Ariel, Durigan, Virginia, Martella, Carolina, Bobat, Antonela, Boggia, Bruno Emilio, Nemi, Sergio Andrés, Tartaglione, Javier Gerardo, Piedimonte, Fabián César, De Bie, Jessie, Reynales Londoño, Humberto, Rodríguez Ordoñez, Paula Andrea, García Cruz, Johanna Marcela, Bautista Toloza, Leonardo, Ladino González, Margot Cecilia, Zambrano Ochoa, Adriana Pilar, Prieto Pradera, Iñigo, Torres Hernandez, Daniela, Mazo Elorza, Diana Patricia, Collazos Lennis, Maria Fernanda, Vanegas Dominguez, Beatriz, Solano Mosquera, Lina Marianur, Fendel, Rolf, Fleischmann, Wim Alexander, Koehne, Erik, Kreidenweiss, Andrea, Köhler, Carsten, Esen, Meral, Horn, Carola, Eberts, Sandra, Kroidl, Arne, Huber, Kristina, Thiel, Verena, Mazara Rosario, Sonia, Reyes, Gilda, Rivera, Laura, Donastorg, Yeycy, Lantigua, Flavia, Torres Almanzar, Dania, Candelario, Rosalba, Peña Mendez, Lourdes, Rosario Gomez, Nadia, Portolés-Pérez, Antonio, Ascaso del Río, Ana, Laredo Velasco, Leonor, Bustinduy Odriozola, Maria Jesus, Larrea Arranz, Igor, Martínez Alcorta, Luis Ignacio, Durán Laviña, María Isabel, Imaz-Ayo, Natale, Meijide, Susana, García-de-Vicuña, Aitor, Santorcuato, Ana, Gallego, Mikel, Aguirre-García, Gloria Mayela, Olmos Vega, Jocelyn, González Limón, Pablo, Vázquez Villar, Andrea, Chávez Barón, Jaime, Arredondo Saldaña, Felipe, Luján Palacios, Juan de Dios, Camacho Choza, Laura Julia, Vázquez Saldaña, Eduardo Gabriel, Ortega Dominguez, Sandra Janeth, Vega Orozco, Karen Sofia, Torres Quiroz, Ivonne Aimee, Martinez Avendaño, Alejandro, Herrera Sanchez, Javier, Guzman, Esperanza, Castro Castrezana, Laura, Ruiz Palacios y Santos, Guillermo Miguel, de Winter, Ronald Frank Jacobus, de Jonge, Hanna K, Schnyder, Jenny L, Boersma, Wim, Hessels, Lisa, Djamin, Remco, van der Sar, Simone, DeAntonio, Rodrigo, Peña, Moisés, Rebollon, Gabriel, Rojas, Marianela, Escobar, Johnny, Hammerschlag Icaza, Bruno, Wong T, Digna Y, Barrera Perigault, Paulo, Ruiz, Sergio, Chan, Milagros, Arias Hoo, Dommie Janneth, Gil, Ana I, Celis, Carlos R, Balmaceda, Maria Pia, Flores, Omar, Ochoa, Mayra, Peña, Bia, de la Flor, Carolina, Webb, Camille María, Cornejo, Enrique, Sanes, Fatima, Mayorga, Valerie, Valdiviezo, Gladys, Ramírez Lamas, Suzanne Pamela, Grandez Castillo, Gustavo Alberto, Lama, Javier R, Matta Aguirre, Milagros Erika, Arancibia Luna, Lesly Angela, Carbajal Paulet, Óscar, Zambrano Ortiz, José, Camara, Anais, Guzman Quintanilla, Fernanda, Diaz-Parra, Carmen, Morales-Oliva, Jose, Cornejo, Rubelio E, Ricalde, Sheby A, Vidal, Jhonny, Rios Nogales, Luis, Cheatham-Seitz, Darline, Gregoraci, Giorgia, Brecx, Alain, Walz, Lisa, Vahrenhorst, Dominik, Seibel, Tobias, Quintini, Gianluca, Kremsner, Peter G, Ahuad Guerrero, Rodolfo Andrés, Arana-Arri, Eunate, Aroca Martinez, Gustavo Jose, Bonten, Marc, Chandler, Reynaldo, Corral, Gonzalo, De Block, Eddie Jan Louis, Ecker, Lucie, Gabor, Julian Justin, Garcia Lopez, Carlos Alberto, Gonzales, Lucy, Granados González, María Angélica, Gorini, Nestor, Grobusch, Martin P, Hrabar, Adrian D, Junker, Helga, Kimura, Alan, Lanata, Claudio F, Lehmann, Clara, Leroux-Roels, Isabel, Mann, Philipp, Martinez-Reséndez, Michel Fernando, Ochoa, Theresa J, Poy, Carlos Alberto, Reyes Fentanes, Maria Jose, Rivera Mejia, Luis Maria, Ruiz Herrera, Vida Veronica, Sáez-Llorens, Xavier, Schönborn-Kellenberger, Oliver, Schunk, Mirjam, Sierra Garcia, Alexandra, Vergara, Itziar, Verstraeten, Thomas, Vico, Marisa, and Oostvogels, Lidia

Published
2022
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7. Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in children and infants: two clinical trials

Author

Sáez-Llorens, Xavier, Bandyopadhyay, Ananda S, Gast, Christopher, Leon, Tirza De, DeAntonio, Rodrigo, Jimeno, Jose, Caballero, Maria Isabel, Aguirre, Gabriela, Oberste, M Steven, Weldon, William C, Konopka-Anstadt, Jennifer L, Modlin, John, Bachtiar, Novilia S, Fix, Alan, Konz, John, Clemens, Ralf, Costa Clemens, Sue Ann, and Rüttimann, Ricardo

Published
2021
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8. Confronting the challenge: a regional perspective by the Latin American pediatric infectious diseases society (SLIPE) expert group on respiratory syncytial virus--tackling the burden of disease and implementing preventive solutions.

Author

Debbag, Roberto, Ávila-Agüero, María L., Brea, José, Brenes-Chacon, Helena, Colomé, Manuel, de Antonio, Rodrigo, Díaz-Díaz, Alejandro, Falleiros-Arlant, Luiza Helena, Fernández, Gerardo, Gentile, Angela, Gutiérrez, Iván Felipe, Jarovsky, Daniel, Juárez, María del Valle, López-Medina, Eduardo, Mascareñas, Abiel, Ospina-Henao, Sebastián, Safadi, Marco A., Sáez-Llorens, Xavier, Soriano-Fallas, Alejandra, and Torres, Juan P.

Published
2024
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12. Immunogenicity and safety of one versus two doses of tetravalent dengue vaccine in healthy children aged 2–17 years in Asia and Latin America: 18-month interim data from a phase 2, randomised, placebo-controlled study

Author

Sáez-Llorens, Xavier, Tricou, Vianney, Yu, Delia, Rivera, Luis, Jimeno, José, Villarreal, Ana Cecilia, Dato, Epiphany, Mazara, Sonia, Vargas, Maria, Brose, Manja, Rauscher, Martina, Tuboi, Suely, Borkowski, Astrid, and Wallace, Derek

Published
2018
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13. Corrigendum to “Safety and immunogenicity of mRNA-LNP COVID-19 vaccine CVnCoV in Latin American adults: A phase 2 randomized study” [Vaccine: X 11 (2022) 100189]

Author

Sáez-Llorens, Xavier, primary, Lanata, Claudio, additional, Aranguren, Elaine, additional, Celis, Carlos R., additional, Cornejo, Rubelio, additional, DeAntonio, Rodrigo, additional, Ecker, Lucie, additional, Garrido, Diegi, additional, Gil, Ana I., additional, Gonzales, Marina, additional, Hess-Holtz, Morgan, additional, Leroux-Roels, Geert, additional, Junker, Helga, additional, Kays, Sarah-Katharina, additional, Koch, Sven D., additional, Lazzaro, Sandra, additional, Mann, Philipp, additional, Quintini, Gianluca, additional, Srivastava, Barkha, additional, Vahrenhorst, Dominik, additional, von Eisenhart-Rothe, Philipp, additional, Wolz, Olaf-Oliver, additional, and Oostvogels, Lidia, additional

Published
2023
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14. Safety and immunogenicity of a ChAd155-vectored respiratory syncytial virus vaccine in infants 6–7 months of age: a phase 1/2 randomized trial

Author

Sáez-Llorens, Xavier, primary, Norero, Ximena, additional, Mussi-Pinhata, Marisa Márcia, additional, Luciani, Kathia, additional, Salamanca de la Cueva, Ignacio, additional, Díez-Domingo, Javier, additional, Lopez-Medina, Eduardo, additional, Epalza, Cristina, additional, Brzostek, Jerzy, additional, Szymański, Henryk, additional, Boucher, François D, additional, Cetin, Benhur S, additional, De Leon, Tirza, additional, Cagri Dinleyici, Ener, additional, Marín Gabriel, Miguel Ángel, additional, Ince, Tolga, additional, Macias-Parra, Mercedes, additional, Langley, Joanne M, additional, Martinón-Torres, Federico, additional, Rämet, Mika, additional, Kuchar, Ernest, additional, Pinto, Jorge, additional, Puthanakit, Thanyawee, additional, Baquero-Artigao, Fernando, additional, Castelli Gattinara, Guido, additional, Merino Arribas, Jose Manuel, additional, Ramos Amador, Jose Tomas, additional, Szenborn, Leszek, additional, Tapiero, Bruce, additional, Anderson, Evan J, additional, Campbell, James D, additional, Faust, Saul N, additional, Nikic, Vanja, additional, Zhou, Yingjun, additional, Pu, Wenji, additional, Friel, Damien, additional, Dieussaert, Ilse, additional, Gonzalez Lopez, Antonio, additional, McPhee, Roderick, additional, Stoszek, Sonia K, additional, and Vanhoutte, Nicolas, additional

Published
2023
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16. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus Vaccine in Infants 6–7 Months of age: A Phase 1/2 Randomized Trial.

Author

Sáez-Llorens, Xavier, Norero, Ximena, Mussi-Pinhata, Marisa Márcia, Luciani, Kathia, Cueva, Ignacio Salamanca de la, Díez-Domingo, Javier, Lopez-Medina, Eduardo, Epalza, Cristina, Brzostek, Jerzy, Szymański, Henryk, Boucher, François D, Cetin, Benhur S, Leon, Tirza De, Dinleyici, Ener Cagri, Gabriel, Miguel Ángel Marín, Ince, Tolga, Macias-Parra, Mercedes, Langley, Joanne M, Martinón-Torres, Federico, and Rämet, Mika

Subjects
*RESPIRATORY syncytial virus, *VIRAL vaccines, *IMMUNE response, *RESPIRATORY syncytial virus infections, *INFANTS, *HUMAN metapneumovirus infection, *NEUTRALIZATION tests
Abstract

Background Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections in infants. This phase 1/2, observer-blind, randomized, controlled study assessed the safety and immunogenicity of an investigational chimpanzee-derived adenoviral vector RSV vaccine (ChAd155-RSV, expressing RSV F, N, and M2-1) in infants. Methods Healthy 6- to 7-month-olds were 1:1:1-randomized to receive 1 low ChAd155-RSV dose (1.5 × 1010 viral particles) followed by placebo (RSV_1D); 2 high ChAd155-RSV doses (5 × 1010 viral particles) (RSV_2D); or active comparator vaccines/placebo (comparator) on days 1 and 31. Follow-up lasted approximately 2 years. Results Two hundred one infants were vaccinated (RSV_1D: 65; RSV_2D: 71; comparator: 65); 159 were RSV-seronaive at baseline. Most solicited and unsolicited adverse events after ChAd155-RSV occurred at similar or lower rates than after active comparators. In infants who developed RSV infection, there was no evidence of vaccine-associated enhanced respiratory disease (VAERD). RSV-A neutralizing titers and RSV F-binding antibody concentrations were higher post–ChAd155-RSV than postcomparator at days 31, 61, and end of RSV season 1 (mean follow-up, 7 months). High-dose ChAd155-RSV induced stronger responses than low-dose, with further increases post–dose 2. Conclusions ChAd155-RSV administered to 6- to 7-month-olds had a reactogenicity/safety profile like other childhood vaccines, showed no evidence of VAERD, and induced a humoral immune response. Clinical Trials Registration.  NCT03636906. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Humoral and intestinal immunity induced by new schedules of bivalent oral poliovirus vaccine and one or two doses of inactivated poliovirus vaccine in Latin American infants: an open-label randomised controlled trial

Author

Asturias, Edwin J, Bandyopadhyay, Ananda S, Self, Steve, Rivera, Luis, Saez-Llorens, Xavier, Lopez, Eduardo, Melgar, Mario, Gaensbauer, James T, Weldon, William C, Oberste, M Steven, Borate, Bhavesh R, Gast, Chris, Clemens, Ralf, Orenstein, Walter, O'Ryan G, Miguel, Jimeno, José, Clemens, Sue Ann Costa, Ward, Joel, and Rüttimann, Ricardo

Published
2016
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19. Immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age: A phase 2 randomized, double-blind trial

Author

López, Pio, primary, López-Medina, Eduardo, additional, Sáez-Llorens, Xavier, additional, deAntonio, Rodrigo, additional, Masuda, Taisei, additional, Mendelman, Paul M., additional, Sherwood, James, additional, Baehner, Frank, additional, and Borkowski, Astrid, additional

Published
2023
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20. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus (RSV) Vaccine in Healthy RSV-Seropositive Children 12–23 Months of Age

Author

Díez-Domingo, Javier, primary, Sáez-Llorens, Xavier, additional, Rodriguez-Weber, Miguel A, additional, Epalza, Cristina, additional, Chatterjee, Archana, additional, Chiu, Cheng-Hsun, additional, Lin, Chien-Yu, additional, Berry, Andrea A, additional, Martinón-Torres, Federico, additional, Baquero-Artigao, Fernando, additional, Langley, Joanne M, additional, Ramos Amador, José T, additional, Domachowske, Joseph B, additional, Huang, Li-Min, additional, Chiu, Nan-Chang, additional, Esposito, Susanna, additional, Moris, Philippe, additional, Lien-Anh Nguyen, Thi, additional, Nikic, Vanja, additional, Woo, Wayne, additional, Zhou, Yingjun, additional, Dieussaert, Ilse, additional, Leach, Amanda, additional, Gonzalez Lopez, Antonio, additional, and Vanhoutte, Nicolas, additional

Published
2022
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21. Meningococcal disease in North America: Updates from the Global Meningococcal Initiative

Author

Asturias, Edwin J., primary, Bai, Xilian, additional, Bettinger, Julie A., additional, Borrow, Ray, additional, Castillo, Delia Nais, additional, Caugant, Dominique A., additional, Chacon, Grettel Chanto, additional, Dinleyici, Ener Cagri, additional, Echaniz-Aviles, Gabriela, additional, Garcia, Luis, additional, Glennie, Linda, additional, Harrison, Lee H., additional, Howie, Rebecca L., additional, Itsko, Mark, additional, Lucidarme, Jay, additional, Marin, Jose Eduardo Oliva, additional, Marjuki, Henju, additional, McNamara, Lucy A., additional, Mustapha, Mustapha M., additional, Robinson, Joan L., additional, Romeu, Belkis, additional, Sadarangani, Manish, additional, Sáez-Llorens, Xavier, additional, Sáfadi, Marco A.P., additional, Stephens, David S., additional, Stuart, James M., additional, Taha, Muhamed-Kheir, additional, Tsang, Raymond S.W., additional, Vazquez, Julio, additional, and De Wals, Philippe, additional

Published
2022
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22. Genetic and phenotypic stability of poliovirus shed from infants who received novel type 2 or Sabin type 2 oral poliovirus vaccines in Panama: an analysis of two clinical trials

Author

Wahid, Rahnuma, primary, Mercer, Laina D, additional, De Leon, Tirza, additional, DeAntonio, Rodrigo, additional, Sáez-Llorens, Xavier, additional, Macadam, Andrew, additional, Chumakov, Konstantin, additional, Strating, Jeroen, additional, Koel, Björn, additional, Konopka-Anstadt, Jennifer L, additional, Oberste, M Steven, additional, Burns, Cara C, additional, Andino, Raul, additional, Tritama, Erman, additional, Bandyopadhyay, Ananda S, additional, Aguirre, Gabriela, additional, Rüttimann, Ricardo, additional, Gast, Chris, additional, and Konz, John O, additional

Published
2022
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23. Prioritising respiratory syncytial virus prevention in low-income and middle-income countries

Author

Carbonell-Estrany, Xavier, Simões, Eric AF, Bont, Louis J, Paes, Bosco A, Ayuk, Adaeze, Gentile, Angela, Greenough, Anne, Moreno, Antonio, Sharma, Arun, Mejias, Asuncion, Rodgers-Gray, Barry, Resch, Bernhard, Fauroux, Brigette, Rodriguez-Martinez, Carlos E, El Saleeby, Chadi, Huskins, W Charles, Cohen, Cheryl, Greenberg, David, Baraldi, Eugenio, Anderson, Evan, Martinon Torres, Federico, Polack, Fernando F, Piedimonte, Giovanni, Nair, Harish, Gans, Hayley, Zar, Heather J, Moriuchi, Hiroyuki, Oshitani, Hitoshi, Mitchell, Ian, Nokes, D James, Sheikh, Jarju, Pernica, Jeffrey, Papenburg, Jesse, Robinson, Joan, De Jesus-Cornejo, Joanne, Langley, Joanne, Liese, Johannes, Figueras Aloy, Jose, Torres Torretti, Juan Pablo, Edwards, Kathryn, Krilov, Leonard, Divaratne, Maduja, Sanchez Luna, Manuel, Lanari, Marcello, Scotta, Marcelo, Garba, Maria, Mori, Masaaki, Cetinkaya, Merih, Goldstein, Mitchell, Khuri-Bulos, Najwa, Vain, Nestor E, Papadopoulus, Nikolaos, Homaira, Nusrat, Ramilo, Octavio, Manzoni, Paolo, Munywoki, Patrick, Piedra, Pedro A, Moschovis, Peter, Openshaw, Peter, Bassat, Quique, Stein, Renato, Thwaites, Richard, Muthugala, Rohitha, Ulloa-Gutierrez, Rolando, Dagan, Ron, Rodriguez Fernandez, Rosa, Kusuda, Satoshi, Madhi, Shabir, Broor, Shobha, Drysdale, Simon B, Basnet, Sudha, Heikkinen, Terho, Avadhanula, Vasanthi, Saez-Llorens, Xavier, Wang, Xin, Li, You, and Mathew, Joseph L

Published
2023
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25. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus (RSV) Vaccine in Healthy RSV-Seropositive Children 12–23 Months of Age.

Author

Díez-Domingo, Javier, Sáez-Llorens, Xavier, Rodriguez-Weber, Miguel A, Epalza, Cristina, Chatterjee, Archana, Chiu, Cheng-Hsun, Lin, Chien-Yu, Berry, Andrea A, Martinón-Torres, Federico, Baquero-Artigao, Fernando, Langley, Joanne M, Amador, José T Ramos, Domachowske, Joseph B, Huang, Li-Min, Chiu, Nan-Chang, Esposito, Susanna, Moris, Philippe, Nguyen, Thi Lien-Anh, Nikic, Vanja, and Woo, Wayne

Subjects
*RESPIRATORY syncytial virus, *IMMUNE response, *CLINICAL trial registries, *VACCINES, *NEUTRALIZATION tests
Abstract

Background Safe and effective respiratory syncytial virus (RSV) vaccines remain elusive. This was a phase I/II trial (NCT02927873) of ChAd155-RSV, an investigational chimpanzee adenovirus-RSV vaccine expressing 3 proteins (fusion, nucleoprotein, and M2-1), administered to 12–23-month-old RSV-seropositive children followed up for 2 years after vaccination. Methods Children were randomized to receive 2 doses of ChAd155-RSV or placebo (at a 1:1 ratio) (days 1 and 31). Doses escalated from 0.5 × 1010 (low dose [LD]) to 1.5 × 1010 (medium dose [MD]) to 5 × 1010 (high dose [HD]) viral particles after safety assessment. Study end points included anti–RSV-A neutralizing antibody (Nab) titers through year 1 and safety through year 2. Results Eighty-two participants were vaccinated, including 11, 14, and 18 in the RSV-LD, RSV-MD, and RSV-HD groups, respectively, and 39 in the placebo groups. Solicited adverse events were similar across groups, except for fever (more frequent with RSV-HD). Most fevers were mild (≤38.5°C). No vaccine-related serious adverse events or RSV-related hospitalizations were reported. There was a dose-dependent increase in RSV-A Nab titers in all groups after dose 1, without further increase after dose 2. RSV-A Nab titers remained higher than prevaccination levels at year 1. Conclusions Three ChAd155-RSV dosages were found to be well tolerated. A dose-dependent immune response was observed after dose 1, with no observed booster effect after dose 2. Further investigation of ChAd155-RSV in RSV-seronegative children is warranted. Clinical Trials Registration NCT02927873. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Author

Kremsner, Peter G, primary, Ahuad Guerrero, Rodolfo Andrés, additional, Arana-Arri, Eunate, additional, Aroca Martinez, Gustavo Jose, additional, Bonten, Marc, additional, Chandler, Reynaldo, additional, Corral, Gonzalo, additional, De Block, Eddie Jan Louis, additional, Ecker, Lucie, additional, Gabor, Julian Justin, additional, Garcia Lopez, Carlos Alberto, additional, Gonzales, Lucy, additional, Granados González, María Angélica, additional, Gorini, Nestor, additional, Grobusch, Martin P, additional, Hrabar, Adrian D, additional, Junker, Helga, additional, Kimura, Alan, additional, Lanata, Claudio F, additional, Lehmann, Clara, additional, Leroux-Roels, Isabel, additional, Mann, Philipp, additional, Martinez-Reséndez, Michel Fernando, additional, Ochoa, Theresa J, additional, Poy, Carlos Alberto, additional, Reyes Fentanes, Maria Jose, additional, Rivera Mejia, Luis Maria, additional, Ruiz Herrera, Vida Veronica, additional, Sáez-Llorens, Xavier, additional, Schönborn-Kellenberger, Oliver, additional, Schunk, Mirjam, additional, Sierra Garcia, Alexandra, additional, Vergara, Itziar, additional, Verstraeten, Thomas, additional, Vico, Marisa, additional, Oostvogels, Lidia, additional, Lovesio, Luciano, additional, Diez, Fabián, additional, Grazziani, Franco, additional, Ganaha, Maria Cristina, additional, Zalatnik, Viviana Judith, additional, Dittrich, Ricardo Julio, additional, Espínola, Lidia, additional, Lambert, Sandra, additional, Longhi, Andrea, additional, Vecchio, Claudia, additional, Mastruzzo, María, additional, Fernandez, Alberto, additional, Borchowiek, Silvina, additional, Potito, Roberto, additional, Ahuad Guerrero, Rodolfo Andres, additional, Guardiani, Fernando Martin, additional, Castella, Sofia, additional, Foccoli, Monica, additional, Pedernera, Aldana, additional, Braida, Ariel, additional, Durigan, Virginia, additional, Martella, Carolina, additional, Bobat, Antonela, additional, Boggia, Bruno Emilio, additional, Nemi, Sergio Andrés, additional, Tartaglione, Javier Gerardo, additional, Piedimonte, Fabián César, additional, De Bie, Jessie, additional, Reynales Londoño, Humberto, additional, Rodríguez Ordoñez, Paula Andrea, additional, García Cruz, Johanna Marcela, additional, Bautista Toloza, Leonardo, additional, Ladino González, Margot Cecilia, additional, Zambrano Ochoa, Adriana Pilar, additional, Prieto Pradera, Iñigo, additional, Torres Hernandez, Daniela, additional, Mazo Elorza, Diana Patricia, additional, Collazos Lennis, Maria Fernanda, additional, Vanegas Dominguez, Beatriz, additional, Solano Mosquera, Lina Marianur, additional, Fendel, Rolf, additional, Fleischmann, Wim Alexander, additional, Koehne, Erik, additional, Kreidenweiss, Andrea, additional, Köhler, Carsten, additional, Esen, Meral, additional, Horn, Carola, additional, Eberts, Sandra, additional, Kroidl, Arne, additional, Huber, Kristina, additional, Thiel, Verena, additional, Mazara Rosario, Sonia, additional, Reyes, Gilda, additional, Rivera, Laura, additional, Donastorg, Yeycy, additional, Lantigua, Flavia, additional, Torres Almanzar, Dania, additional, Candelario, Rosalba, additional, Peña Mendez, Lourdes, additional, Rosario Gomez, Nadia, additional, Portolés-Pérez, Antonio, additional, Ascaso del Río, Ana, additional, Laredo Velasco, Leonor, additional, Bustinduy Odriozola, Maria Jesus, additional, Larrea Arranz, Igor, additional, Martínez Alcorta, Luis Ignacio, additional, Durán Laviña, María Isabel, additional, Imaz-Ayo, Natale, additional, Meijide, Susana, additional, García-de-Vicuña, Aitor, additional, Santorcuato, Ana, additional, Gallego, Mikel, additional, Aguirre-García, Gloria Mayela, additional, Olmos Vega, Jocelyn, additional, González Limón, Pablo, additional, Vázquez Villar, Andrea, additional, Chávez Barón, Jaime, additional, Arredondo Saldaña, Felipe, additional, Luján Palacios, Juan de Dios, additional, Camacho Choza, Laura Julia, additional, Vázquez Saldaña, Eduardo Gabriel, additional, Ortega Dominguez, Sandra Janeth, additional, Vega Orozco, Karen Sofia, additional, Torres Quiroz, Ivonne Aimee, additional, Martinez Avendaño, Alejandro, additional, Herrera Sanchez, Javier, additional, Guzman, Esperanza, additional, Castro Castrezana, Laura, additional, Ruiz Palacios y Santos, Guillermo Miguel, additional, de Winter, Ronald Frank Jacobus, additional, de Jonge, Hanna K, additional, Schnyder, Jenny L, additional, Boersma, Wim, additional, Hessels, Lisa, additional, Djamin, Remco, additional, van der Sar, Simone, additional, DeAntonio, Rodrigo, additional, Peña, Moisés, additional, Rebollon, Gabriel, additional, Rojas, Marianela, additional, Escobar, Johnny, additional, Hammerschlag Icaza, Bruno, additional, Wong T, Digna Y, additional, Barrera Perigault, Paulo, additional, Ruiz, Sergio, additional, Chan, Milagros, additional, Arias Hoo, Dommie Janneth, additional, Gil, Ana I, additional, Celis, Carlos R, additional, Balmaceda, Maria Pia, additional, Flores, Omar, additional, Ochoa, Mayra, additional, Peña, Bia, additional, de la Flor, Carolina, additional, Webb, Camille María, additional, Cornejo, Enrique, additional, Sanes, Fatima, additional, Mayorga, Valerie, additional, Valdiviezo, Gladys, additional, Ramírez Lamas, Suzanne Pamela, additional, Grandez Castillo, Gustavo Alberto, additional, Lama, Javier R, additional, Matta Aguirre, Milagros Erika, additional, Arancibia Luna, Lesly Angela, additional, Carbajal Paulet, Óscar, additional, Zambrano Ortiz, José, additional, Camara, Anais, additional, Guzman Quintanilla, Fernanda, additional, Diaz-Parra, Carmen, additional, Morales-Oliva, Jose, additional, Cornejo, Rubelio E, additional, Ricalde, Sheby A, additional, Vidal, Jhonny, additional, Rios Nogales, Luis, additional, Cheatham-Seitz, Darline, additional, Gregoraci, Giorgia, additional, Brecx, Alain, additional, Walz, Lisa, additional, Vahrenhorst, Dominik, additional, Seibel, Tobias, additional, and Quintini, Gianluca, additional

Published
2022
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30. Characterization of the cell-mediated immune response to Takeda’s live-attenuated tetravalent dengue vaccine in adolescents participating in a phase 2 randomized controlled trial conducted in a dengue-endemic setting

Author

Tricou, Vianney, primary, Gottardo, Raphael, additional, Egan, Michael A., additional, Clement, Frédéric, additional, Leroux-Roels, Geert, additional, Sáez-Llorens, Xavier, additional, Borkowski, Astrid, additional, Wallace, Derek, additional, and Dean, Hansi J., additional

Published
2022
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31. Fecal Shedding of 2 Novel Live Attenuated Oral Poliovirus Type 2 Vaccine Candidates by Healthy Infants Administered Bivalent Oral Poliovirus Vaccine/Inactivated Poliovirus Vaccine: 2 Randomized Clinical Trials

Author

Gast, Christopher, primary, Bandyopadhyay, Ananda S, additional, Sáez-Llorens, Xavier, additional, De Leon, Tirza, additional, DeAntonio, Rodrigo, additional, Jimeno, José, additional, Aguirre, Gabriela, additional, McDuffie, Larin M, additional, Coffee, Elizabeth, additional, Mathis, Demetrius L, additional, Oberste, M Steven, additional, Weldon, William C, additional, Konopka-Anstadt, Jennifer L, additional, Modlin, John, additional, Bachtiar, Novilia S, additional, Fix, Alan, additional, Konz, John, additional, Clemens, Ralf, additional, Costa Clemens, Sue Ann, additional, and Rüttimann, Ricardo, additional

Published
2021
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32. Three-year Efficacy and Safety of Takeda’s Dengue Vaccine Candidate (TAK-003)

Author

Rivera, Luis, primary, Biswal, Shibadas, additional, Sáez-Llorens, Xavier, additional, Reynales, Humberto, additional, López-Medina, Eduardo, additional, Borja-Tabora, Charissa, additional, Bravo, Lulu, additional, Sirivichayakul, Chukiat, additional, Kosalaraksa, Pope, additional, Martinez Vargas, Luis, additional, Yu, Delia, additional, Watanaveeradej, Veerachai, additional, Espinoza, Felix, additional, Dietze, Reynaldo, additional, Fernando, LakKumar, additional, Wickramasinghe, Pujitha, additional, Duarte MoreiraJr, Edson, additional, Fernando, Asvini D, additional, Gunasekera, Dulanie, additional, Luz, Kleber, additional, Venâncioda Cunha, Rivaldo, additional, Rauscher, Martina, additional, Zent, Olaf, additional, Liu, Mengya, additional, Hoffman, Elaine, additional, LeFevre, Inge, additional, Tricou, Vianney, additional, Wallace, Derek, additional, Alera, MariaTheresa, additional, and Borkowski, Astrid, additional

Published
2021
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33. Reactogenicity and safety of ChAd155-vectored respiratory syncytial virus (RSV) vaccine (ChAd155-RSV) administered at different dose levels in infants aged 6–7 months

Author

Pinto, Jorge, Norero, Ximena, Mussi-Pinhata, Marisa Márcia, Merino Arribas, Jose Manuel, Martinón-Torres, Federico, Rämet, Mika, Parra, Mercedes Macias, Luciani, Kathia, Langley, Joanne M, Kuchar, Ernest, Krasnow, Aleksander, Faust, Saul, DİNLEYİCİ, ENER ÇAĞRI, Díez-Domingo, Javier, ÇETİN, BENHUR ŞİRVAN, Castelli Gattinara, Guido, Campbell, James Daniel, D Boucher, Francois, Baquero Artigao, Fernando, Anderson, Evan, Gabriel, Miguel Angel Marin, López-Medina, Eduardo, Seppa, Ilkka, Tapiero, Bruce, Rojo Conejo, Pablo, Szymanski, Henryk, Szenborn, Leszek, Salamanca De La Cueva, Ignacio, Sáez-Llorens, Xavier, Puthanakit, Thanyawee, Dieussaert, Ilse, Friel, Damien, Gonzalez Lopez, Antonio, Mcphee, Roderick, Nikic, Vanja, Stoszek, Sonia K, Woo, Wayne, Vanhoutte, Nicolas, İNCE, OSMAN TOLGA, and Ramos Amador, Jose Tomas

Published
2021

34. ChAd155-vectored respiratory syncytial virus (RSV) investigational vaccine (ChAd155-RSV) is immunogenic when administered at different dose levels in infants aged 6–7 months

Author

Kuchar, Ernest, Langley, Joanne M, Luciani, Kathia, Baquero Artigao, Fernando, İNCE, OSMAN TOLGA, Vanhoutte, Nicolas, Woo, Wayne, Stoszek, Sonia K, Nikic, Vanja, Mcphee, Roderick, Gonzalez Lopez, Antonio, Friel, Damien, Anderson, Evan, D Boucher, Francois, Campbell, James Daniel, Castelli Gattinara, Guido, ÇETİN, BENHUR ŞİRVAN, Díez-Domingo, Javier, DİNLEYİCİ, ENER ÇAĞRI, Epalza, Cristina, Faust, Saul, Krasnow, Aleksander, Parra, Mercedes Macias, Gabriel, Miguel Angel Marin, Martinón-Torres, Federico, Merino Arribas, Jose Manuel, Mussi-Pinhata, Marisa Márcia, Norero, Ximena, Pinto, Jorge, Sáez-Llorens, Xavier, Salamanca De La Cueva, Ignacio, Szenborn, Leszek, Szymanski, Henryk, Tapiero, Bruce, Seppa, Ilkka, López-Medina, Eduardo, Rämet, Mika, Ramos Amador, Jose Tomas, Puthanakit, Thanyawee, and Dieussaert, Ilse

Published
2021

35. Fecal Shedding of 2 Novel Live Attenuated Oral Poliovirus Type 2 Vaccine Candidates by Healthy Infants Administered Bivalent Oral Poliovirus Vaccine/Inactivated Poliovirus Vaccine: 2 Randomized Clinical Trials.

Author

Gast, Christopher, Bandyopadhyay, Ananda S, Sáez-Llorens, Xavier, Leon, Tirza De, DeAntonio, Rodrigo, Jimeno, José, Aguirre, Gabriela, McDuffie, Larin M, Coffee, Elizabeth, Mathis, Demetrius L, Oberste, M Steven, Weldon, William C, Konopka-Anstadt, Jennifer L, Modlin, John, Bachtiar, Novilia S, Fix, Alan, Konz, John, Clemens, Ralf, Clemens, Sue Ann Costa, and Rüttimann, Ricardo

Subjects
ENTEROVIRUSES, POLIOMYELITIS vaccines, POLIO, VACCINES, RESEARCH funding, VIRAL antibodies
Abstract

Background: Primary intestinal immunity through viral replication of live oral vaccine is key to interrupt poliovirus transmission. We assessed viral fecal shedding from infants administered Sabin monovalent poliovirus type 2 vaccine (mOPV2) or low and high doses of 2 novel OPV2 (nOPV2) vaccine candidates.Methods: In 2 randomized clinical trials in Panama, a control mOPV2 study (October 2015 to April 2016) and nOPV2 study (September 2018 to October 2019), 18-week-old infants vaccinated with bivalent oral poliovirus vaccine/inactivated poliovirus vaccine received 1 or 2 study vaccinations 28 days apart. Stools were assessed for poliovirus RNA by polymerase chain reaction (PCR) and live virus by culture for 28 days postvaccination.Results: Shedding data were available from 621 initially reverse-transcription PCR-negative infants (91 mOPV2, 265 nOPV2-c1, 265 nOPV2-c2 recipients). Seven days after dose 1, 64.3% of mOPV2 recipients and 31.3%-48.5% of nOPV2 recipients across groups shed infectious type 2 virus. Respective rates 7 days after dose 2 decreased to 33.3% and 12.9%-22.7%, showing induction of intestinal immunity. Shedding of both nOPV2 candidates ceased at similar or faster rates than mOPV2.Conclusions: Viral shedding of either nOPV candidate was similar or decreased relative to mOPV2, and all vaccines showed indications that the vaccine virus was replicating sufficiently to induce primary intestinal mucosal immunity. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study

Author

Linhares, Alexandre C, Velázquez, F Raúl, Pérez-Schael, Irene, Sáez-Llorens, Xavier, Abate, Hector, Espinoza, Felix, López, Pío, Macías-Parra, Mercedes, Ortega-Barría, Eduardo, Rivera-Medina, Doris Maribel, Rivera, Luis, Pavía-Ruz, Noris, Nuñez, Ernesto, Damaso, Silvia, Ruiz-Palacios, Guillermo M, De Vos, Béatrice, O'Ryan, Miguel, Gillard, Paul, and Bouckenooghe, Alain

Published
2008
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37. Three-year Efficacy and Safety of Takeda's Dengue Vaccine Candidate (TAK-003).

Author

Rivera, Luis, Biswal, Shibadas, Sáez-Llorens, Xavier, Reynales, Humberto, López-Medina, Eduardo, Borja-Tabora, Charissa, Bravo, Lulu, Sirivichayakul, Chukiat, Kosalaraksa, Pope, Vargas, Luis Martinez, Yu, Delia, Watanaveeradej, Veerachai, Espinoza, Felix, Dietze, Reynaldo, Fernando, LakKumar, Wickramasinghe, Pujitha, MoreiraJr, Edson Duarte, Fernando, Asvini D, Gunasekera, Dulanie, and Luz, Kleber

Subjects
DRUG efficacy, RESEARCH, REVERSE transcriptase polymerase chain reaction, DENGUE, VIRAL vaccines, CONFIDENCE intervals, TIME, SERODIAGNOSIS, RANDOMIZED controlled trials, DESCRIPTIVE statistics, DRUG side effects, PATIENT safety
Abstract

Background Takeda's live attenuated tetravalent dengue vaccine candidate (TAK-003) is under evaluation in a long-term clinical trial across 8 dengue-endemic countries. Previously, we have reported its efficacy and safety in both seronegative and seropositive participants and that its performance varies by serotype, with some decline in efficacy from first to second year postvaccination. This exploratory analysis provides an update with cumulative and third-year data. Methods Healthy 4–16 year olds (n = 20099) were randomized 2:1 to receive TAK-003 or placebo (0, 3 month schedule). The protocol included baseline serostatus testing of all participants and detection of all symptomatic dengue throughout the trial with a serotype specific reverse transcriptase-polymerase chain reaction. Results Cumulative efficacy after 3 years was 62.0% (95% confidence interval, 56.6–66.7) against virologically confirmed dengue (VCD) and 83.6% (76.8–88.4) against hospitalized VCD. Efficacy was 54.3% (41.9–64.1) against VCD and 77.1% (58.6–87.3) against hospitalized VCD in baseline seronegatives, and 65.0% (58.9–70.1) against VCD and 86.0% (78.4–91.0) against hospitalized VCD in baseline seropositives. Efficacy against VCD during the third year declined to 44.7% (32.5–54.7), whereas efficacy against hospitalized VCD was sustained at 70.8% (49.6–83.0). Rates of serious adverse events were 2.9% in TAK-003 group and 3.5% in placebo group during the ongoing long-term follow-up (ie, second half of the 3 years following vaccination), but none were related. No important safety risks were identified. Conclusions TAK-003 was efficacious against symptomatic dengue over 3 years. Efficacy declined over time but remained robust against hospitalized dengue. A booster dose evaluation is planned. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Performance of a Point of Care Test for Detecting IgM and IgG Antibodies Against SARS-CoV-2 and Seroprevalence in Blood Donors and Health Care Workers in Panama

Author

Villarreal, Alcibiades, primary, Rangel, Giselle, additional, Zhang, Xu, additional, Wong, Digna, additional, Britton, Gabrielle, additional, Fernandez, Patricia L., additional, Pérez, Ambar, additional, Oviedo, Diana, additional, Restrepo, Carlos, additional, Carreirra, María B., additional, Sambrano, Dilcia, additional, Eskildsen, Gilberto A., additional, De La Guardia, Carolina, additional, Flores-Cuadra, Julio, additional, Carrera, Jean-Paul, additional, Zaldivar, Yamitzel, additional, Franco, Danilo, additional, López-Vergès, Sandra, additional, Zhang, Dexi, additional, Fan, Fangjing, additional, Wang, Baojun, additional, Sáez-Llorens, Xavier, additional, DeAntonio, Rodrigo, additional, Torres-Atencio, Ivonne, additional, Blanco, Isabel, additional, Subía, Fernando Diaz, additional, Mudarra, Laiss, additional, Benzadon, Aron, additional, Valverde, Walter, additional, López, Lineth, additional, Hurtado, Nicolás, additional, Rivas, Neyla, additional, Jurado, Julio, additional, Carvallo, Aixa, additional, Rodriguez, Juan, additional, Perez, Yaseikiry, additional, Morris, Johanna, additional, Luque, Odemaris, additional, Cortez, David, additional, Ortega-Barria, Eduardo, additional, Kosagisharaf, Rao, additional, Lleonart, Ricardo, additional, Li, Chong, additional, and Goodridge, Amador, additional

Published
2021
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39. A Multicenter, Longitudinal Maternal and Birth Cohort Study in Latin America to Assess Prevalent Respiratory Tract Infections in Children from 0 to 5 Years of Age. The MINERVAL Study

Author

DeAntonio, Rodrigo, López-Medina, Eduardo, Sáez-Llorens, Xavier, Cadena, Andrés, Reynales, Humberto, Jimeno, José, López, Pío, Hernández, Carolina, Granados, María, Martínez, Kevin, Cantor, Erika, Dávalos, Diana M, Mejías, Asunción, and Ramilo, Octavio

Published
2024
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41. Efficacy and Safety of the CVnCoV SARS-CoV-2 mRNA Vaccine Candidate: Results from Herald, a Phase 2b/3, Randomised, Observer-Blinded, Placebo-Controlled Clinical Trial in Ten Countries in Europe and Latin America

Author

Kremsner, Peter G., primary, Guerrero, Rodolfo Andrés Ahuad, additional, Arana, Eunate, additional, Aroca Martinez, Gustavo Jose, additional, Bonten, Marc J.M., additional, Chandler, Reynaldo, additional, Corral, Gonzalo, additional, De Block, Eddie Jan Louis, additional, Ecker, Lucie, additional, Gabor, Julian Justin, additional, Garcia Lopez, Carlos Alberto, additional, Gonzales, Lucy, additional, Granados González, María Angélica, additional, Gorini, Nestor, additional, Grobusch, Martin P., additional, Hrabar, Adrian D., additional, Junker, Helga, additional, Kimura, Alan, additional, Lanata, Claudio F., additional, Lehmann, Clara, additional, Leroux-Roels, Isabel, additional, Mann, Philipp, additional, Martinez-Reséndez, Michel Fernando, additional, Ochoa, Theresa, additional, Poy, Carlos Alberto, additional, Reyes Fentanes, Maria Jose, additional, Mejia, Luis Maria Rivera, additional, Ruiz Herrera, Vida Veronica, additional, Sáez-Llorens, Xavier, additional, Schönborn-Kellenberger, Oliver, additional, Schunk, Mirjam, additional, Garcia, Alexandra Sierra, additional, Vergara, Itziar, additional, Verstraeten, Thomas, additional, Vico, Marisa, additional, Oostvogels, Lidia, additional, and Group, HERALD Study, additional

Published
2021
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42. Safety and Immunogenicity of mRNA-LNP COVID-19 Vaccine CVnCoV in Latin American Adults; A Phase 2 Randomized Study

Author

Sáez-Llorens, Xavier, primary, Lanata, Claudio F., additional, Aranguren, Elaine, additional, Celis, Carlos R., additional, Cornejo, Rubelio, additional, DeAntonio, Rodrigo, additional, Ecker, Lucie, additional, Garrido, Diegi, additional, Gil, Ana I., additional, Gonzales, Marina, additional, Hess-Holtz, Morgan, additional, Leroux-Roels, Geert, additional, Junker, Helga, additional, Kays, Sarah-Katharina, additional, Koch, Sven D., additional, Lazzaro, Sandra, additional, Mann, Philipp, additional, Quintini, Gianluca, additional, Srivastava, Barkha, additional, Vahrenhorst, Dominik, additional, von Eisenhart-Rothe, Philipp, additional, Wolz, Olaf-Oliver, additional, and Oostvogels, Lidia, additional

Published
2021
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46. CONTRIBUTORS

Author

Aaskov, John G., primary, Abdel-Rahman, Susan M., additional, Aebi, Christoph, additional, Ament, Marvin E., additional, Anderson, Marsha S., additional, Arnon, Stephen S., additional, Arvin, Ann M., additional, Atkins, Jane T., additional, Atmar, Robert L., additional, Baker, Carol J., additional, Baltimore, Robert S., additional, Barenkamp, Stephen J., additional, Barnett, Elizabeth D., additional, Basow, Robert D., additional, Beisel, William R., additional, Bell, Beth P., additional, Benard, Gil, additional, Bernstein, David I., additional, Bernt, Kathrin M., additional, Berry, Andrea A., additional, Bluestone, Charles D., additional, Blumer, Jeffrey L., additional, Bortolussi, Robert, additional, Boyanton, Bobby L., additional, Boyer, Kenneth M., additional, Bradley, John S., additional, Brady, Michael T., additional, Britt, William J., additional, Broderick, Annemarie, additional, Bronstein, David E., additional, Bruckner, David A., additional, Buckingham, Steven C., additional, Burgos, Ana, additional, Byington, Carrie L., additional, Campbell, Judith R., additional, Cantu, Samson, additional, Chacko, Mariam R., additional, Chapman, Louisa E., additional, Charrel, Rémi N., additional, Chen, Tempe K., additional, Cherry, James D., additional, Chesney, P. Joan, additional, Chilakapati, Madhuri C., additional, Chinen, Javier, additional, Ching, Natascha, additional, Clark, H. Fred, additional, Cleary, Thomas G., additional, Coats, David K., additional, Correa, Armando G., additional, Cross, J. Thomas, additional, Cutrer, William B., additional, Dagan, Ronald, additional, Dassey, David E., additional, Davis, Jeffrey P., additional, Demmler-Harrison, Gail J., additional, Dennehy, Penelope H., additional, Doan, Minh L., additional, Dobson, Simon R., additional, Drutz, Jan E., additional, Edelstein, Paul H., additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, English, B. Keith, additional, Estripeaut, Dora, additional, Fan, Leland L., additional, Feigin, Ralph D., additional, Ferry, George D., additional, Fiore, Anthony E., additional, Fischer, Philip R., additional, Fisher, Randall G., additional, Flynn, Patricia M., additional, Flynn, Thomas R., additional, Frenkel, Lisa M., additional, Friedman, Ellen M., additional, Friedman, Richard A., additional, Garcia, Lynne S., additional, Gavin, Patrick J., additional, Gerber, Michael A., additional, Gershon, Anne A., additional, Gilger, Mark A., additional, Gillespie, Susan L., additional, Glaze, Daniel G., additional, Glezen, W. Paul, additional, Glodé, Mary P., additional, Goldmann, Donald A., additional, Goldstein, Ellie J.C., additional, Goldstein, Nira A., additional, Gonzales, Edmond T., additional, Gorman, Mark P., additional, Green, Michael D., additional, Greenberg, David, additional, Groll, Andreas H., additional, Grose, Charles, additional, Gubler, Duane J., additional, Guerrero, Roberto A., additional, Guevara, Javier Nieto, additional, Gutierrez, Kathleen M., additional, Hall, Caroline Breese, additional, Halstead, Scott B., additional, Hamano, Shinjiro, additional, Hamill, Richard J., additional, Hammerschlag, Margaret R., additional, Hanson, I. Celine, additional, Harik, Nada, additional, Harrison, Rick E., additional, Healy, C. Mary, additional, Heininger, Ulrich, additional, Heresi, Gloria P., additional, Hiatt, Peter W., additional, Hill, Harry R., additional, Hilmers, David C., additional, Hoffman, Jill A., additional, Hon, Ellis K.L., additional, Hostetter, Margaret K., additional, Hotez, Peter J., additional, Hughes, Walter T., additional, Hulten, Kristina G., additional, Hunstad, David A., additional, Hurwitz, Eugene S., additional, Huskins, W. Charles, additional, Hyun, David Y., additional, Jackson, Mary Anne, additional, Jacobs, Michael R., additional, Jacobs, Richard F., additional, Jaeger, Jenifer L., additional, Jhaveri, Ravi R., additional, Johnston, Samantha, additional, Jonas, Maureen M., additional, Julapalli, Meena R., additional, Kaplan, Edward L., additional, Kaplan, Sheldon L., additional, Karpen, Saul J., additional, Kearns, Gregory L., additional, Keller, Margaret A., additional, Khoury, Chaouki K., additional, Kleiman, Martin B., additional, Klein, Jerome O., additional, Kline, Mark W., additional, Knapp, Katherine M., additional, Kokkinos, Heidi M., additional, Krause, Peter J., additional, Krilov, Leonard R., additional, Krogstad, Paul, additional, Kuhls, Thomas L., additional, de Lamballerie, Xavier, additional, La Pine, Timothy R., additional, Laurens, Matthew B., additional, Leach, Charles T., additional, Leggiadro, Robert J., additional, Lennon, Diana R., additional, Lentzsch-Parcells, Carolyn, additional, Leroy, Eric, additional, Leung, Chi Wai, additional, Levy, Moise L., additional, Lewis, Karen, additional, Losikoff, Phyllis T., additional, Lotze, Timothy Edward, additional, Lowry, Adam W., additional, Mailman, Timothy, additional, Maloney, Susan A., additional, Mascola, Laurene, additional, Mason, Edward O., additional, Matson, David O., additional, Mayer, Alan N., additional, Mazade, Marc A., additional, McAuley, James B., additional, McCracken, George H., additional, McIntosh, Kenneth, additional, McJunkin, James E., additional, McKee, Kelly T., additional, McLeod, Rima L., additional, McLin, Valérie A., additional, Mendes-Giannini, Maria José Soares, additional, Meyers, Wayne M., additional, Michaels, Marian G., additional, Michelow, Ian C., additional, Milisavljevic, Vladana, additional, Miller, Aaron M., additional, Miller, James N., additional, Miller, Marjorie J., additional, Mills, James N., additional, Minnich, Linda L., additional, Moran, Ann, additional, Murphy, James R., additional, Nag, Pratip K., additional, Nania, Joseph J., additional, Nataro, James P., additional, Nicome, Roger K., additional, Nielsen-Saines, Karin, additional, Nieves, Delma J., additional, Oberhelman, Richard A., additional, Ochoa, Theresa J., additional, Oermann, Christopher M., additional, Olteanu, Alina, additional, Overturf, Gary D., additional, Palazzi, Debra L., additional, Pannaraj, Pia S., additional, Patel, Janak A., additional, Patrick, Christian C., additional, Paysse, Evelyn A., additional, Pérez, Norma, additional, Peters, C.J., additional, Petri, William A., additional, Phillips, Brandon Lane, additional, Pickering, Larry K., additional, Piecuch, Joseph F., additional, Pinheiro, Francisco P., additional, Plotkin, Stanley A., additional, Pomeroy, Scott L., additional, Pong, Alice, additional, Pugatch, David L., additional, Purcell, Joan S., additional, Ramraj, Ramya, additional, Remington, Jack S., additional, Rodriguez, Carina A., additional, Romero, José R., additional, Ross, Benjamin A., additional, Ross, Lawrence A., additional, Rowen, Judith L., additional, Rupprecht, Charles E., additional, Sáez-Llorens, Xavier, additional, Saiman, Lisa, additional, Geme, Joseph W. St., additional, Sánchez, Pablo J., additional, Sass, Laura A., additional, Sattler, Carlos A., additional, Schulte, Danica J., additional, Schutze, Gordon E., additional, Seeborg, Filiz O., additional, Shapiro, Eugene D., additional, Shapiro, Nina L., additional, Shearer, William T., additional, Shehab, Ziad M., additional, Shenep, Jerry L., additional, Shields, W. Donald, additional, Shimizu-Cohen, Robyn, additional, Shulman, Stanford T., additional, Simos, Constantine, additional, Smith, Arnold L., additional, Soden, Jason S., additional, Staat, Mary Allen, additional, Starke, Jeffrey R., additional, Stechenberg, Barbara W., additional, Steinbach, William J., additional, Steinkuller, Paul G., additional, Stiehm, E. Richard, additional, Stovall, Stephanie H., additional, Suen, Jeffrey, additional, Sumaya, Ciro V., additional, Summer, Andrea P., additional, Swanson, Douglas S., additional, Tan, Tina Q., additional, Tanowitz, Herbert B., additional, Tesh, Robert B., additional, Toltzis, Philip, additional, Topazian, Richard G., additional, Tosi, Michael F., additional, Travassos da Rosa, Amelia P.A., additional, Tsai, Theodore F., additional, Valdez, Tulio A., additional, Vallejo, Jesus G., additional, Vanchiere, John A., additional, Vasconcelos, Pedro Fernando da C., additional, Velarde, Jorge J., additional, Versalovic, James, additional, Wald, Ellen R., additional, Walsh, Douglas S., additional, Walsh, Edward E., additional, Walsh, Thomas J., additional, Ward, Mark A., additional, Ward, Richard L., additional, Weinberg, Michelle, additional, Welliver, Robert C., additional, Wheeler, J. Gary, additional, White, A. Clinton, additional, Whitworth, Suzanne, additional, Wiedermann, Bernhard L., additional, Williams-Bouyer, Natalie, additional, Wittner, Murray, additional, Woods, Charles R., additional, Yen, Kimberly G., additional, Yogev, Ram, additional, Young, Edward J., additional, and Zaoutis, Theoklis E., additional

Published
2009
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50. Contributors

Author

Adderson, Elisabeth E., primary, Adler-Shohet, Felice C., additional, Amieva, Manuel R., additional, Armstrong, Gregory L., additional, Arvelo, Wences, additional, Arvin, Ann M., additional, Asher, David M., additional, Ashkenazi, Shai, additional, Ault, Kevin A., additional, Baker, Carol J., additional, Barson, William J., additional, Bell, Beth P., additional, Bell, Michael J., additional, Benjamin, Daniel K., additional, Bialek, Stephanie R., additional, Blythe, Margaret J., additional, Bocchini, Joseph A., additional, Boeckh, Michael, additional, Bower, William A., additional, Boyer, Kenneth M., additional, Braden, Christopher R., additional, Bradley, John S., additional, Brady, Michael T., additional, Bratcher, Denise, additional, Braverman, Paula K., additional, Bresee, Joseph S., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Browning, John C., additional, Buckingham, Steven C., additional, Buescher, E. Stephen, additional, Burns, Jane L., additional, Cappello, Michael, additional, Carter, Bryan D., additional, Chadwick, Ellen Gould, additional, Chesney, Patricia Joan, additional, Childs, James E., additional, Christenson, John C., additional, Cleary, Thomas G., additional, Coffin, Susan E., additional, Connelly, Beverly L., additional, Cotton, C. Michael, additional, Cox, Elaine, additional, Cramer, Robert Andrew, additional, Crockett, Maryanne E., additional, Crowe, James E., additional, Cunningham, Dennis J., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daum, Robert S., additional, de la Morena, Maite, additional, Demmler, Gail J., additional, Despommier, Dickson D., additional, Diefenbach, Karen A., additional, Dominguez, Elidia, additional, Downs, Stephen M., additional, Dvorak, Christopher C., additional, Edwards, Kathryn, additional, Edwards, Morven S., additional, Englund, Janet A., additional, Erard, Véronique, additional, Eremeeva, Marina E., additional, Finelli, Lyn, additional, Finn, Adam, additional, Fiore, Anthony E., additional, Fischer, Marc, additional, Fitch, Sarah J., additional, Flynn, Patricia M., additional, Fortenberry, J. Dennis, additional, Fox, LeAnne M., additional, Freedman, David O., additional, Gans, Hayley A., additional, Gerber, Michael A., additional, Gigliotti, Francis, additional, Gilligan, Peter, additional, Gold, Benjamin D., additional, Goldman, David L., additional, Goldstein, Brahm, additional, Goldstein, Susan T., additional, Gould, Jane M., additional, Green, Michael, additional, Greene, Sharon K., additional, Greenwald, Mark J., additional, Grom, Alexei A., additional, Grossman, Leigh B., additional, Guerra, Marta A., additional, Gutierrez, Kathleen, additional, Guzman-Cottrill, Judith A., additional, Hall, Caroline Breese, additional, Harper, Marvin B., additional, Haslam, David B., additional, Hayes, Edward B., additional, Hendley, J. Owen, additional, Henrickson, Kelly J., additional, Henry, Marion C.W., additional, Hilinski, Joseph A., additional, Hotez, Peter J., additional, Ingram, David L., additional, Jackson, Mary Anne, additional, Jacobs, Richard F., additional, Karlowicz, M. Gary, additional, Katz, Ben Z., additional, Keystone, Jay S., additional, Kimberlin, David W., additional, Kleiman, Martin B., additional, Klein, Jerome O., additional, Kline, Mark W., additional, Koh, Andrew Y., additional, Koranyi, Katalin I., additional, Korgenski, E. Kent, additional, Leggiadro, Robert J., additional, Levy, Moise L., additional, Lewis, David B., additional, Lieberman, Jay M., additional, Limaye, Abhijit, additional, Lohr, Jacob A., additional, Lorber, Bennett, additional, Long, Sarah S., additional, Low, Donald E., additional, Lowell, Gina, additional, Lowenthal, Elizabeth, additional, Lujan-Zilbermann, Jorge, additional, Luzuriaga, Katherine, additional, MacDonald, Noni E., additional, Maldonado, Yvonne A., additional, Mani, Chitra S., additional, Marcinak, John F., additional, Marcon, Mario J., additional, Marshall, Gary S., additional, Martin, Stacey W., additional, Massung, Robert F., additional, Mast, Eric E., additional, Mazzulli, Tony, additional, McCracken, George H., additional, McGregor, Robert S., additional, McIntosh, Kenneth, additional, McLean, Catherine A., additional, McLeod, Rima, additional, McMillan, Julia A., additional, McQuiston, Jennifer H., additional, Meissner, H. Cody, additional, Menon, Manoj P., additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Millon, Juan Carlos, additional, Modlin, John F., additional, Moore, Matthew R., additional, Moore, Zack S., additional, Moran, Mary M., additional, Moro, Pedro L., additional, Moss, R. Lawrence, additional, Murray, Dennis L., additional, Nadel, Simon, additional, Nataro, James P., additional, Neely, Michael N., additional, Nizet, Victor, additional, Norrby-Teglund, Anna, additional, Nyquist, Ann-Christine, additional, Ochoa, Theresa J., additional, O'Hara, Sara M., additional, Orenstein, Walter A., additional, Ortega-Barria, Eduardo, additional, Overturf, Gary D., additional, Paddock, Christopher D., additional, Painter, John A., additional, Pappas, Diane E., additional, Parise, Monica E., additional, Pass, Robert F., additional, Patterson, Thomas F., additional, Pavia, Andrew T., additional, Pelton, Stephen I., additional, Peter, Georges, additional, Peters, Timothy R., additional, Petri, William A., additional, Pickering, Larry K., additional, Pizzo, Philip A., additional, Pollard, Andrew J., additional, Poutanen, Susan M., additional, Powell, Dwight A., additional, Prince, Alice S., additional, Prober, Charles G., additional, Rangel, Shawn J., additional, Rawstron, Sarah Anne, additional, Reed, Michael D., additional, Reller, Megan E., additional, Richards, Frank O., additional, Rodgers, Gail L., additional, Romero, Luz I., additional, Rotbart, Harley A., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ruiz-Palacios, Guillermo M., additional, Sáez-Llorens, Xavier, additional, Saiman, Lisa, additional, Sauberan, Jason B., additional, Sawyer, Mark H., additional, Schantz, Peter M., additional, Schlager, Theresa A., additional, Schutze, Gordon E., additional, Schwartz, Benjamin, additional, Schwartz, Richard H., additional, Schwarzwald, Heidi, additional, Shah, Samir S., additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shetty, Avinash K., additional, Siegel, Jane D., additional, Siegel, Robert D., additional, Sipe, Walter E.B., additional, Skarbinski, Jacek, additional, Smith, P. Brian, additional, Snyder, John D., additional, Solaymani-Mohammadi, Shahram, additional, Staat, Mary Allen, additional, Starke, Jeffrey R., additional, Steinbach, William J., additional, Stephens, Ina, additional, St. Geme, Joseph W., additional, Subbarao, Kanta, additional, Sullivan, John L., additional, Sutton, Deanna A., additional, Sutton, Madeline Y., additional, Swerdlow, David L., additional, Tauxe, Robert V., additional, Thompson, Herbert A., additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Todd, James K., additional, Toltzis, Philip, additional, Tsai, Theodore F., additional, Wald, Ellen R., additional, Wallace, Richard J., additional, Weinberg, Geoffrey A., additional, Weiss, Avery H., additional, White, A. Clinton, additional, Widdowson, Marc-Alain, additional, Williams, Ian T., additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wilson, Craig M., additional, Winkelstein, Jerry A., additional, Workowski, Kimberly, additional, Wright, Terry W., additional, Yazigi, Nada, additional, Yogev, Ram, additional, Young, Edward J., additional, and Zaoutis, Theoklis E., additional

Published
2008
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