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1. Prognostic impact of the surgical deep margin distance of invasive acral melanoma of the sole: A multi-institutional retrospective study

Author

S. Koizumi, Y. Ichigozaki, H. Kitagawa, Y. Kiniwa, S. Sato, T. Takai, R. Doi, T. Ito, Y. Kuwatsuka, T. Maekawa, J. Asai, T. Miyagawa, S. Matsushita, T. Funakoshi, Y. Yamamoto, A. Kishi, T. Takenouchi, H. Kokubu, S. Ito, Y. Umeda, H. Uchi, S. Ishizuki, S. Iino, T. Nakagawa, K. Inafuku, T. Kaneko, M. Nakagawa, H. Kamiya, T. Hoashi, M. Arima, K. Asagoe, A. Hiura, T. Haga, U. Iwasawa, M. Ishikawa, K. Manabe, N. Hatta, S. Minami, and Y. Nakamura

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2024
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2. A retrospective multicenter study on the real-world efficacy of chemotherapy in 204 Japanese patients with advanced extra-mammary Paget's disease

Author

A. Miyashita, S. Fukushima, K. Yoshino, H. Kato, N. Yamazaki, S. Kawashima, Y. Yamamoto, Y. Nakamura, Y. Kiniwa, S. Ishizuki, T. Maekawa, E. Okada, T. Fujimura, K. Fujii, Y. Fujisawa, J. Asai, A. Otsuka, J. Morinaga, and S. Matsushita

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2024
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3. Adjuvant therapy for Asian patients with resected stage III/IV BRAF V600-mutant melanoma with more than 3 years of follow-up: A multicenter retrospective study in Japan

Author

K. Namikawa, S. Mori, Y. Kiniwa, T. Takenouchi, M. Nakamura, K. Oashi, S. Yoshikawa, Y. Muto, H. Uchi, K. Yoshino, T. Maekawa, S. Ohe, H. Uhara, Y. Ichigozaki, J. Asai, Y. Nakamura, S. Ishizuki, T. Matsuzawa, H. Kitagawa, M. Nomura, T. Funakoshi, S. Matsushita, T. Maeda, N. Hatta, K. Tsutsui, T. Nakagawa, T. Hoashi, H. Ishikawa, K. Nakama, T. Ito, T. Miyagawa, A. Nishizawa, T. Yanagi, Y. Kato, S. Fujiwara, Y. Yamamoto, H. Iwata, D. Ogata, and Y. Fujisawa

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2024
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10. 2‐mm surgical margins are adequate for most basal cell carcinomas in Japanese: a retrospective multicentre study on 1000 basal cell carcinomas

Author

Y. Nakamura, S. Matsushita, R. Tanaka, S. Saito, R. Araki, Y. Teramoto, M. Aoki, K. Yamamura, Y. Fujisawa, T.J. Brinker, and A. Yamamoto

Subjects
medicine.medical_specialty, Skin Neoplasms, business.industry, Statistical difference, Margins of Excision, Confidential interval, Dermatology, Gold standard (test), 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Japan, Carcinoma, Basal Cell, Interquartile range, 030220 oncology & carcinogenesis, Cohort, medicine, Humans, Basal cell, Radiology, business, Retrospective Studies
Abstract

BACKGROUND Surgery is the gold standard for basal cell carcinomas (BCC). Current recommended surgical margins for BCCs are determined from studies in Caucasian populations. However, the appropriate surgical margins for BCCs in non-white races are unclear. OBJECTIVES To investigate the accuracy of preoperative determination of clinical tumour borders and appropriate surgical margins in Japanese patients with BCC. METHODS The maximum calculated differences in distance between the preoperatively determined surgical margins and the actual histologic tumour side margins were considered as 'accuracy gaps' of clinical tumour borders. Estimated side margin positivity rates (ESMPRs) with narrower (2 and 3 mm) surgical margins were calculated on the basis of the accuracy gaps. RESULTS Overall, 1000 surgically excised BCCs from 980 Japanese patients were included. The most frequent histologic subtype was nodular BCC (67%). The median accuracy gap was 0.3 mm [interquartile range (IQR): -0.5 to +1 mm]. The ESMPRs with 2- and 3-mm surgical margins were 3.8% and 1.4%, respectively. Only the ESMPRs between the well-defined (n = 921) and poorly defined clinical tumour border groups (n = 79) showed statistical difference [2-mm margin: 3.1% vs. 11.7%, OR: 3.89, 95% confidential interval (CI): 1.41-10.71, P

Published
2020
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12. OP0238 CLINICAL ANALYSIS OF 34 CASES OF CARDIAC COMPLICATIONS REQUIRING SURGICAL INTERVENTION IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ASSESSMENT ABOUT MECHANISM OF DEVELOPMENT WITH IMMUNOLOGICAL ANALYSIS

Author

T. Kawamoto, H. Amano, S. Matsushita, K. Minowa, M. Matsushita, K. Yamaji, A. Amano, and N. Tamura

Subjects
Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract

BackgroundIn cases of systematic lupus erythematosus (SLE) that lead to surgery due to the development of heart diseases such as valvular disease, ischemic heart disease and aortic aneurysm, early detection and careful monitoring are important. An absence of background diseases or immunopathological examination of the myocardial tissue in SLE cases with cardiovascular lesions demonstrates the lack of knowledge in this area. In recent years, however, there have been reports of neutrophil extracellular traps being involved in the fulminant onset of SLE.ObjectivesThis study aimed to analyze clinically and immunohistopathologically the pathophysiology of heart diseases associated with SLE.MethodsWe performed left atrial appendage resection in 34 patients, including patients with cardiovascular lesions, who underwent heart surgery for SLE complications from 2012 to 2021. Tissue analysis was conducted in 9 cases. The left atrial appendage, in cases of non-collagen valvular disease, was used as the control. Tissue staining of cardiomyocytes was carried out by adding anti-neutrophil extracellular(NE) antibodies(Abs) to anti-human IgG antibody (Ab), anti-IgM Ab and anti-C3 Ab.ResultsOf the 34 SLE patients 14 had valvular disease, 8 had ischemic heart disease and 12 had aneurysms. Preoperative SLE activity was relatively stable with only 1 patient below the CH50 standard and 6 patients above the anti-DNA Ab standard. The Ab positivity rate for the patients in this study was higher than that of the 687 SLE patients who were previously tested in 2019. The presence of anti-CL Abs was 55.6%, which was higher than the 25.5% observed in previous SLE patients. In this study, anti-SS-A and anti-RNP Abs tended to be relatively numerous. An example of immunohistochemical staining of IgG in the left atrial appendage is presented (Figure 1a). IgG deposits were not observed on the left side of the myocardial fibers in the control group, whereas IgG deposits were observed on the right side in the SLE group. Deposits were also observed in tissues that were not located in the affected areas. The presence or absence of tissue deposition in the myocardial fibers and clinical findings in 2 cases of the control group and 9 cases of the SLE complication group are reported in Table 1. IgG deposits were found in the myocardial fibers of 6 of the 9 patients in the SLE complication group, and deposits were found in the left atrial appendage tissue regardless of the type of heart disease, suggesting a potential change in the heart tissue. In the SLE group, 5 cases were positive for antiphospholipid (APS) Abs, while 7 cases were positive for either anti-SS-A or anti-RNP Abs. Only 2 cases had elevated preoperative anti-DNA Ab and complement reduction. Of the SLE complication group, 2 of the 9 cases were negative for all Abs but IgG deposits were observed in a case. Of these 4 cases were selected and stained with anti-IgM, anti-C3 and anti-NE Abs. However IgM and C3 deposits were only observed in one patient who developed myocardial infarction at the age of 39 and was triple positive for APS, anti-SS-A and anti-RNP Abs (Figure 1b). There were also no NE deposits in any of the cases. Even if complement and anti-DNA Ab levels in the serum are normal, attention should be paid to heart disease complications during the long-term observation of SLE patients. In particular, attention should be paid to various autoantibody-positive cases such as APS, anti-SS-A Ab and anti-RNP Ab. The anti-NE Ab was not stained in this study because the tissue was different from the lesion site and because it occurred during the chronic course.ConclusionIn SLE patients who developed cardiovascular lesions and required surgery, immunological abnormalities may occur in the myocardial tissue even if serum complement and anti-DNA Ab levels are stable.References[1]Stephane Zuily et al. Valvular Curr Rheumatol Rep (2013) 15:320.[2]Zawadowski GM et al. Lupus. 2012;21(13):1378-84.[3]Daniel Appelgren et al. Autoimmunity 2018,vol51,No.6,310-318.Disclosure of InterestsNone declared

Published
2022
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13. SYMBA: An end-to-end VLBI synthetic data generation pipeline. Simulating Event Horizon Telescope observations of M 87

Author

F. Roelofs, M. Janssen, I. Natarajan, R. Deane, J. Davelaar, H. Olivares, O. Porth, S. N. Paine, K. L. Bouman, R. P. J. Tilanus, I. M. van Bemmel, H. Falcke, K. Akiyama, A. Alberdi, W. Alef, K. Asada, R. Azulay, A. Baczko, D. Ball, M. Baloković, J. Barrett, D. Bintley, L. Blackburn, W. Boland, G. C. Bower, M. Bremer, C. D. Brinkerink, R. Brissenden, S. Britzen, A. E. Broderick, D. Broguiere, T. Bronzwaer, D. Byun, J. E. Carlstrom, A. Chael, C. Chan, S. Chatterjee, K. Chatterjee, M. Chen, Y. Chen, I. Cho, P. Christian, J. E. Conway, J. M. Cordes, G. B. Crew, Y. Cui, M. De Laurentis, J. Dempsey, G. Desvignes, J. Dexter, S. S. Doeleman, R. P. Eatough, V. L. Fish, E. Fomalont, R. Fraga-Encinas, P. Friberg, C. M. Fromm, J. L. Gómez, P. Galison, C. F. Gammie, R. García, O. Gentaz, B. Georgiev, C. Goddi, R. Gold, M. Gu, M. Gurwell, K. Hada, M. H. Hecht, R. Hesper, L. C. Ho, P. Ho, M. Honma, C. L. Huang, L. Huang, D. H. Hughes, S. Ikeda, M. Inoue, S. Issaoun, D. J. James, B. T. Jannuzi, B. Jeter, W. Jiang, M. D. Johnson, S. Jorstad, T. Jung, M. Karami, R. Karuppusamy, T. Kawashima, G. K. Keating, M. Kettenis, J. Kim, M. Kino, J. Y. Koay, P. M. Koch, S. Koyama, M. Kramer, C. Kramer, T. P. Krichbaum, C. Kuo, T. R. Lauer, S. Lee, Y. Li, Z. Li, M. Lindqvist, R. Lico, K. Liu, E. Liuzzo, W. Lo, A. P. Lobanov, L. Loinard, C. Lonsdale, R. Lu, N. R. MacDonald, J. Mao, S. Markoff, D. P. Marrone, A. P. Marscher, I. Martí-Vidal, S. Matsushita, L. D. Matthews, L. Medeiros, K. M. Menten, Y. Mizuno, I. Mizuno, J. M. Moran, K. Moriyama, M. Moscibrodzka, C. Müller, H. Nagai, N. M. Nagar, M. Nakamura, R. Narayan, G. Narayanan, R. Neri, C. Ni, A. Noutsos, H. Okino, G. N. Ortiz-León, T. Oyama, F. Özel, D. C. M. Palumbo, N. Patel, U. Pen, D. W. Pesce, V. Piétu, R. Plambeck, A. PopStefanija, B. Prather, J. A. Preciado-López, D. Psaltis, H. Pu, V. Ramakrishnan, R. Rao, M. G. Rawlings, A. W. Raymond, L. Rezzolla, B. Ripperda, A. Rogers, E. Ros, M. Rose, A. Roshanineshat, H. Rottmann, A. L. Roy, C. Ruszczyk, B. R. Ryan, K. L. J. Rygl, S. Sánchez, D. Sánchez-Arguelles, M. Sasada, T. Savolainen, F. P. Schloerb, K. Schuster, L. Shao, Z. Shen, D. Small, B. Won Sohn, J. SooHoo, F. Tazaki, P. Tiede, M. Titus, K. Toma, P. Torne, E. Traianou, T. Trent, S. Trippe, S. Tsuda, H. J. van Langevelde, D. R. van Rossum, J. Wagner, J. Wardle, J. Weintroub, N. Wex, R. Wharton, M. Wielgus, G. N. Wong, Q. Wu, A. Young, K. Young, Z. Younsi, F. Yuan, Y. Yuan, J. A. Zensus, G. Zhao, S. Zhao, Z. Zhu, High Energy Astrophys. & Astropart. Phys (API, FNWI), Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Instituto de RadioAstronomía Milimétrica (IRAM), Event Horizon Telescope, Academy of Finland, European Commission, Alexander von Humboldt Foundation, John Templeton Foundation, China Scholarship Council, Comisión Nacional de Investigación Científica y Tecnológica (Chile), Consejo Nacional de Ciencia y Tecnología (México), European Research Council, Generalitat Valenciana, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Gordon and Betty Moore Foundation, Istituto Nazionale di Fisica Nucleare, Japanese Government, Japan Society for the Promotion of Science, Chinese Academy of Sciences, Max Planck Society, Ministry of Science and Technology (Taiwan), National Aeronautics and Space Administration (US), National Science Foundation (US), National Natural Science Foundation of China, Natural Sciences and Engineering Research Council of Canada, National Research Foundation of Korea, Netherlands Organization for Scientific Research, National Research Foundation (South Africa), Russian Science Foundation, Ministero dell'Istruzione, dell'Università e della Ricerca, Roelofs, F., Janssen, M., Natarajan, I., Deane, R., Davelaar, J., Olivares, H., Porth, O., Paine, S. N., Bouman, K. L., Tilanus, R. P. J., Van Bemmel, I. M., Falcke, H., Akiyama, K., Alberdi, A., Alef, W., Asada, K., Azulay, R., Baczko, A., Ball, D., Balokovic, M., Barrett, J., Bintley, D., Blackburn, L., Boland, W., Bower, G. C., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Byun, D., Carlstrom, J. E., Chael, A., Chan, C., Chatterjee, S., Chatterjee, K., Chen, M., Chen, Y., Cho, I., Christian, P., Conway, J. E., Cordes, J. M., Crew, G. B., Cui, Y., De Laurentis, M., Dempsey, J., Desvignes, G., Dexter, J., Doeleman, S. S., Eatough, R. P., Fish, V. L., Fomalont, E., Fraga-Encinas, R., Friberg, P., Fromm, C. M., Gomez, J. L., Galison, P., Gammie, C. F., Garcia, R., Gentaz, O., Georgiev, B., Goddi, C., Gold, R., Gu, M., Gurwell, M., Hada, K., Hecht, M. H., Hesper, R., Ho, L. C., Ho, P., Honma, M., Huang, C. L., Huang, L., Hughes, D. H., Ikeda, S., Inoue, M., Issaoun, S., James, D. J., Jannuzi, B. T., Jeter, B., Jiang, W., Johnson, M. D., Jorstad, S., Jung, T., Karami, M., Karuppusamy, R., Kawashima, T., Keating, G. K., Kettenis, M., Kim, J., Kino, M., Koay, J. Y., Koch, P. M., Koyama, S., Kramer, M., Kramer, C., Krichbaum, T. P., Kuo, C., Lauer, T. R., Lee, S., Li, Y., Li, Z., Lindqvist, M., Lico, R., Liu, K., Liuzzo, E., Lo, W., Lobanov, A. P., Loinard, L., Lonsdale, C., Lu, R., Macdonald, N. R., Mao, J., Markoff, S., Marrone, D. P., Marscher, A. P., Marti-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Mizuno, Y., Mizuno, I., Moran, J. M., Moriyama, K., Moscibrodzka, M., Muller, C., Nagai, H., Nagar, N. M., Nakamura, M., Narayan, R., Narayanan, G., Neri, R., Ni, C., Noutsos, A., Okino, H., Ortiz-Leon, G. N., Oyama, T., Ozel, F., Palumbo, D. C. M., Patel, N., Pen, U., Pesce, D. W., Pietu, V., Plambeck, R., Popstefanija, A., Prather, B., Preciado-Lopez, J. A., Psaltis, D., Pu, H., Ramakrishnan, V., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ripperda, B., Rogers, A., Ros, E., Rose, M., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruszczyk, C., Ryan, B. R., Rygl, K. L. J., Sanchez, S., Sanchez-Arguelles, D., Sasada, M., Savolainen, T., Schloerb, F. P., Schuster, K., Shao, L., Shen, Z., Small, D., Won Sohn, B., Soohoo, J., Tazaki, F., Tiede, P., Titus, M., Toma, K., Torne, P., Traianou, E., Trent, T., Trippe, S., Tsuda, S., Van Langevelde, H. J., Van Rossum, D. R., Wagner, J., Wardle, J., Weintroub, J., Wex, N., Wharton, R., Wielgus, M., Wong, G. N., Wu, Q., Young, A., Young, K., Younsi, Z., Yuan, F., Yuan, Y., Zensus, J. A., Zhao, G., Zhao, S., Zhu, Z., Universidad de Concepción, Anne Lähteenmäki Group, Radboud University, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, and Astronomy

Subjects
010504 meteorology & atmospheric sciences, Computer science, Image quality, Pipeline (computing), Astronomy, black hole physics, 01 natural sciences, Black hole physic, 0103 physical sciences, Very-long-baseline interferometry, Calibration, Angular resolution, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Remote sensing, Event Horizon Telescope, astro-ph.HE, Atmospheric effect, Astrophysics::Instrumentation and Methods for Astrophysics, techniques: high angular resolution, Astronomy and Astrophysics, telescopes, Black hole physics, Atmospheric effects, Galaxies, Techniques, high angular resolution [Techniques], 13. Climate action, Space and Planetary Science, techniques: interferometric, nuclei [Galaxies], interferometric, nuclei, interferometric [Techniques], galaxies: nuclei, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], high angular resolution, Telescopes, atmospheric effects, astro-ph.IM
Abstract

Context. Realistic synthetic observations of theoretical source models are essential for our understanding of real observational data. In using synthetic data, one can verify the extent to which source parameters can be recovered and evaluate how various data corruption effects can be calibrated. These studies are the most important when proposing observations of new sources, in the characterization of the capabilities of new or upgraded instruments, and when verifying model-based theoretical predictions in a direct comparison with observational data. Aims. We present the SYnthetic Measurement creator for long Baseline Arrays (SYMBA), a novel synthetic data generation pipeline for Very Long Baseline Interferometry (VLBI) observations. SYMBA takes into account several realistic atmospheric, instrumental, and calibration effects. Methods. We used SYMBA to create synthetic observations for the Event Horizon Telescope (EHT), a millimetre VLBI array, which has recently captured the first image of a black hole shadow. After testing SYMBA with simple source and corruption models, we study the importance of including all corruption and calibration effects, compared to the addition of thermal noise only. Using synthetic data based on two example general relativistic magnetohydrodynamics (GRMHD) model images of M 87, we performed case studies to assess the image quality that can be obtained with the current and future EHT array for different weather conditions. Results. Our synthetic observations show that the effects of atmospheric and instrumental corruptions on the measured visibilities are significant. Despite these effects, we demonstrate how the overall structure of our GRMHD source models can be recovered robustly with the EHT2017 array after performing calibration steps, which include fringe fitting, a priori amplitude and network calibration, and self-calibration. With the planned addition of new stations to the EHT array in the coming years, images could be reconstructed with higher angular resolution and dynamic range. In our case study, these improvements allowed for a distinction between a thermal and a non-thermal GRMHD model based on salient features in reconstructed images. © 2020 ESO., This work is supported by the ERC Synergy Grant "BlackHoleCam: Imaging the Event Horizon of Black Holes" (Grant 610058). I. Natarajan and R. Deane are grateful for the support from the New Scientific Frontiers with Precision Radio Interferometry Fellowship awarded by the South African Radio Astronomy Observatory (SARAO), which is a facility of the National Research Foundation (NRF), an agency of the Department of Science and Technology (DST) of South Africa. The authors of the present paper further thank the following organizations and programmes: the Academy of Finland (projects 274477, 284495, 312496); the Advanced European Network of E-infrastructures for Astronomy with the SKA (AENEAS) project, supported by the European Commission Framework Programme Horizon 2020 Research and Innovation action under grant agreement 731016; the Alexander von Humboldt Stiftung; the Black Hole Initiative at Harvard University, through a grant (60477) from the John Templeton Foundation; the China Scholarship Council; Comision Nacional de Investigacio Cientifica y Tecnologica (CONICYT, Chile, via PIA ACT172033, Fondecyt 1171506, BASAL AFB-170002, ALMAconicyt 31140007); Consejo Nacional de Ciencia y Tecnologia (CONACYT, Mexico, projects 104497, 275201, 279006, 281692); the Delaney Family via the Delaney Family John A. Wheeler Chair at Perimeter Institute; Direccion General de Asuntos del Personal Academico-Universidad Nacional Autonoma de Mexico (DGAPA-UNAM, project IN112417); the Generalitat Valenciana postdoctoral grant APOSTD/2018/177; the Gordon and Betty Moore Foundation (grants GBMF-3561, GBMF-5278); the Istituto Nazionale di Fisica Nucleare (INFN) sezione di Napoli, iniziative specifiche TEONGRAV; the GenT Program (Generalitat Valenciana) under project CIDEGENT/2018/021; the International Max Planck Research School for Astronomy and Astrophysics at the Universities of Bonn and Cologne; the Jansky Fellowship program of the National Radio Astronomy Observatory (NRAO); the Japanese Government (Monbukagakusho: MEXT) Scholarship; the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for JSPS Research Fellowship (JP17J08829); the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS, grants QYZDJ-SSW-SLH057, QYZDJ-SSW-SYS008); the Leverhulme Trust Early Career Research Fellowship; the Max-Planck-Gesellschaft (MPG); the Max Planck Partner Group of the MPG and the CAS; the MEXT/JSPS KAKENHI (grants 18KK0090, JP18K13594, JP18K03656, JP18H03721, 18K03709, 18H01245, 25120007); the MIT International Science and Technology Initiatives (MISTI) Funds; the Ministry of Science and Technology (MOST) of Taiwan (105-2112-M-001-025-MY3, 106-2112-M-001-011, 106-2119-M-001027, 107-2119-M-001-017, 107-2119-M-001-020, and 107-2119-M-110-005); the National Aeronautics and Space Administration (NASA, Fermi Guest Investigator grant 80NSSC17K0649); NASA through the NASA Hubble Fellowship grant #HST-HF2-51431.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc. , for NASA, under contract NAS5-26555; the National Institute of Natural Sciences (NINS) of Japan; the National Key Research and Development Program of China (grant 2016YFA0400704, 2016YFA0400702); the National Science Foundation (NSF, grants AST-0096454, AST-0352953, AST-0521233, AST-0705062, AST-0905844, AST-0922984, AST-1126433, AST-1140030, DGE-1144085, AST-1207704, AST-1207730, AST-1207752, MRI-1228509, OPP-1248097, AST-1310896, AST-1312651, AST-1337663, AST-1440254, AST-1555365, AST-1715061, AST-1615796, AST-1716327, OISE-1743747, AST-1816420); the Natural Science Foundation of China (grants 11573051, 11633006, 11650110427, 10625314, 11721303, 11725312, 11933007); the Natural Sciences and Engineering Research Council of Canada (NSERC, including a Discovery Grant and the NSERC Alexander Graham Bell Canada Graduate Scholarships-Doctoral Program); the National Youth Thousand Talents Program of China; the National Research Foundation of Korea (the Global PhD Fellowship Grant: grants NRF-2015H1A2A1033752, 2015-R1D1A1A01056807, the Korea Research Fellowship Program: NRF-2015H1D3A1066561); the Netherlands Organization for Scientific Research (NWO) VICI award (grant 639.043.513) and Spinoza Prize SPI 78-409; the New Scientific Frontiers with Precision Radio Interferometry Fellowship awarded by the South African Radio Astronomy Observatory (SARAO), which is a facility of the National Research Foundation (NRF), an agency of the Department of Science and Technology (DST) of South Africa; the Onsala Space Observatory (OSO) national infrastructure, for the provisioning of its facilities/observational support (OSO receives funding through the Swedish Research Council under grant 2017-00648) the Perimeter Institute for Theoretical Physics (research at Perimeter Institute is supported by the Government of Canada through the Department of Innovation, Science and Economic Development and by the Province of Ontario through the Ministry of Research, Innovation and Science); the Princeton/Flatiron Postdoctoral Prize Fellowship; the Russian Science Foundation (grant 17-12-01029); the Spanish Ministerio de Economia y Competitividad (grants AYA2015-63939-C21-P, AYA2016-80889-P); the State Agency for Research of the Spanish MCIU through the "Center of Excellence Severo Ochoa" award for the Instituto de Astrofisica de Andalucia (SEV-2017-0709); the Toray Science Foundation; the US Department of Energy (USDOE) through the Los Alamos National Laboratory (operated by Triad National Security, LLC, for the National Nuclear Security Administration of the USDOE (Contract 89233218CNA000001)); the Italian Ministero dell'Istruzione Universita e Ricerca through the grant Progetti Premiali 2012-iALMA (CUP C52I13000140001); the European Union's Horizon 2020 research and innovation programme under grant agreement No 730562 RadioNet; ALMA North America Development Fund; the Academia Sinica; Chandra TM6-17006X. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), supported by NSF grant ACI-1548562, and CyVerse, supported by NSF grants DBI-0735191, DBI-1265383, and DBI1743442. XSEDE Stampede2 resource at TACC was allocated through TGAST170024 and TG-AST080026N. XSEDE JetStream resource at PTI and TACC was allocated through AST170028. The simulations were performed in part on the SuperMUC cluster at the LRZ in Garching, on the LOEWE cluster in CSC in Frankfurt, and on the HazelHen cluster at the HLRS in Stuttgart. This research was enabled in part by support provided by Compute Ontario (http://computeontario.ca), Calcul Quebec (http://www. calculquebec.ca) and Compute Canada (http://www.computecanada.ca).We thank the sta ff at the participating observatories, correlation centers, and institutions for their enthusiastic support. This paper makes use of the following ALMA data: ADS/JAO.ALMA#2017.1.00841.V. ALMA is a partnership of the European Southern Observatory (ESO; Europe, representing its member states), NSF, and National Institutes of Natural Sciences of Japan, together with National Research Council (Canada), Ministry of Science and Technology (MOST; Taiwan), Academia Sinica Institute of Astronomy and Astrophysics (ASIAA; Taiwan), and Korea Astronomy and Space Science Institute (KASI; Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, Associated Universities, Inc. (AUI)/NRAO, and the National Astronomical Observatory of Japan (NAOJ). The NRAO is a facility of the NSF operated under cooperative agreement by AUI. APEX is a collaboration between the Max-Planck-Institut fur Radioastronomie (Germany), ESO, and the Onsala Space Observatory (Sweden). The SMA is a joint project between the SAO and ASIAA and is funded by the Smithsonian Institution and the Academia Sinica. The JCMT is operated by the East Asian Observatory on behalf of the NAOJ, ASIAA, and KASI, as well as the Ministry of Finance of China, Chinese Academy of Sciences, and the National Key R&D Program (No. 2017YFA0402700) of China. Additional funding support for the JCMT is provided by the Science and Technologies Facility Council (UK) and participating universities in the UK and Canada. The LMT is a project operated by the Instituto Nacional de Astrofisica, Optica, y Electronica (Mexico) and the University of Massachusetts at Amherst (USA). The IRAM 30m telescope on Pico Veleta, Spain is operated by IRAM and supported by CNRS (Centre National de la Recherche Scientifique, France), MPG (Max-Planck-Gesellschaft, Germany) and IGN (Instituto Geografico Nacional, Spain). The SMT is operated by the Arizona Radio Observatory, a part of the Steward Observatory of the University of Arizona, with financial support of operations from the State of Arizona and financial support for instrumentation development from the NSF. The SPT is supported by the National Science Foundation through grant PLR-1248097. Partial support is also provided by the NSF Physics Frontier Center grant PHY-1125897 to the Kavli Institute of Cosmological Physics at the University of Chicago, the Kavli Foundation and the Gordon and Betty Moore Foundation grant GBMF 947. The SPT hydrogen maser was provided on loan from the GLT, courtesy of ASIAA. The EHTC has received generous donations of FPGA chips from Xilinx Inc., under the Xilinx University Program. The EHTC has benefited from technology shared under open-source license by the Collaboration for Astronomy Signal Processing and Electronics Research (CASPER). The EHT project is grateful to T4Science and Microsemi for their assistance with Hydrogen Masers. This research has made use of NASA's Astrophysics Data System. We gratefully acknowledge the support provided by the extended staff of the ALMA, both from the inception of the ALMA Phasing Project through the observational campaigns of 2017 and 2018. We would like to thank A. Deller and W. Brisken for EHT-specific support with the use of DiFX. We acknowledge the significance that Maunakea, where the SMA and JCMT EHT stations are located, has for the indigenous Hawaiian people. The software presented in this work makes use of the Numpy (van derWalt et al. 2011), Scipy (Jones et al. 2001), Astropy (Astropy Collaboration 2013, 2018) libraries and the KERN software bundle (Molenaar & Smirnov 2018).

Published
2020
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14. Anti-PD1 checkpoint inhibitor therapy in acral melanoma: a multicenter study of 193 Japanese patients

Author

Y. Nakamura, K. Namikawa, K. Yoshino, S. Yoshikawa, H. Uchi, K. Goto, S. Fukushima, Y. Kiniwa, T. Takenouchi, H. Uhara, T. Kawai, N. Hatta, T. Funakoshi, Y. Teramoto, A. Otsuka, H. Doi, D. Ogata, S. Matsushita, T. Isei, T. Hayashi, Y. Shibayama, and N. Yamazaki

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Skin Neoplasms, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Pembrolizumab, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, Stage (cooking), Melanoma, Retrospective Studies, business.industry, Common Terminology Criteria for Adverse Events, Hematology, Immunotherapy, medicine.disease, Clinical trial, 030104 developmental biology, 030220 oncology & carcinogenesis, Toxicity, Nivolumab, business
Abstract

Acral melanoma (AM) is an epidemiologically and molecularly distinct entity that is underrepresented in clinical trials on immunotherapy in melanoma. We aimed to analyze the efficacy of anti-programmed cell death 1 (anti-PD-1) antibodies in advanced AM.We retrospectively evaluated unresectable stage III or stage IV AM patients treated with an anti-PD-1 antibody in any line at 21 Japanese institutions between 2014 and 2018. The clinicobiologic characteristics, objective response rate (ORR, RECIST), survival estimated using Kaplan-Meier analysis, and toxicity (Common Terminology Criteria for Adverse Events 4.0.) were analyzed to estimate the efficacy of the anti-PD-1 antibodies.In total, 193 patients (nail apparatus, 70; palm and sole, 123) were included in the study. Anti-PD-1 antibody was used as first-line therapy in 143 patients (74.1%). Baseline lactate dehydrogenase (LDH) was within the normal concentration in 102 patients (52.8%). The ORR of all patients was 16.6% (complete response, 3.1%; partial response, 13.5%), and the median overall survival (OS) was 18.1 months. Normal LDH concentrations showed a significantly stronger association with better OS than abnormal concentrations (median OS 24.9 versus 10.7 months; P0.001). Although baseline characteristics were similar between the nail apparatus and the palm and sole groups, ORR was significantly lower in the nail apparatus group [6/70 patients (8.6%) versus 26/123 patients (21.1%); P = 0.026]. Moreover, the median OS in this group was significantly poorer (12.8 versus 22.3 months; P = 0.03).Anti-PD-1 antibodies have limited efficacy in AM patients. Notably, patients with nail apparatus melanoma had poorer response and survival, making nail apparatus melanoma a strong candidate for further research on the efficacy of novel combination therapies with immune checkpoint inhibitors.

Published
2020

15. Anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy in unresectable or metastatic mucosal melanoma: a retrospective, multicenter study of 329 Japanese cases (JMAC study)

Author

Shintaro Saito, Y. Umeda, Yukiko Kiniwa, Yukiko Teramoto, Takashi Inozume, N. Yamazaki, Dai Ogata, Satoshi Fukushima, Noriki Fujimoto, Osamu Yamasaki, Tatsuya Takenouchi, Yasuo Nakai, A. Takahashi, Ryo Tanaka, Yasuhiro Nakamura, S. Yoshikawa, Takehiro Onuma, M. Otsuka, Kotaro Nagase, Yutaka Kuwatsuka, S. Matsushita, Natsuki Baba, Taisuke Matsuya, Motoo Nomura, Kenjiro Namikawa, Taiki Isei, Takahide Kaneko, Masazumi Onishi, Hiroshi Kato, Takeo Maekawa, and Atsushi Otsuka

Subjects
anti-PD-1 antibody, Cancer Research, medicine.medical_specialty, Skin Neoplasms, anti-CTLA-4 antibody, Combination therapy, chemical and pharmacologic phenomena, Ipilimumab, Pembrolizumab, Gastroenterology, Japan, Internal medicine, medicine, Humans, CTLA-4 Antigen, mucosal melanoma, ipilimumab, Adverse effect, Melanoma, Aged, Retrospective Studies, Original Research, nivolumab, business.industry, Hazard ratio, Mucosal melanoma, medicine.disease, Confidence interval, Oncology, Immunotherapy, pembrolizumab, Nivolumab, business, medicine.drug
Abstract

Background Anti-programmed cell death protein 1 (PD-1) antibody monotherapy (PD1) has led to favorable responses in advanced non-acral cutaneous melanoma among Caucasian populations; however, recent studies suggest that this therapy has limited efficacy in mucosal melanoma (MCM). Thus, advanced MCM patients are candidates for PD1 plus anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) combination therapy (PD1 + CTLA4). Data on the efficacy of immunotherapy in MCM, however, are limited. We aimed to compare the efficacies of PD1 and PD1 + CTLA4 in Japanese advanced MCM patients. Patients and methods We retrospectively assessed advanced MCM patients treated with PD1 or PD1 + CTLA4 at 24 Japanese institutions. Patient baseline characteristics, clinical responses (RECIST), progression-free survival (PFS), and overall survival (OS) were estimated using Kaplan–Meier analysis, and toxicity was assessed to estimate the efficacy and safety of PD1 and PD1 + CTLA4. Results Altogether, 329 patients with advanced MCM were included in this study. PD1 and PD1 + CTLA4 were used in 263 and 66 patients, respectively. Baseline characteristics were similar between both treatment groups, except for age (median age 71 versus 65 years; P < 0.001). No significant differences were observed between the PD1 and PD1 + CTLA4 groups with respect to objective response rate (26% versus 29%; P = 0.26) or PFS and OS (median PFS 5.9 months versus 6.8 months; P = 0.55, median OS 20.4 months versus 20.1 months; P = 0.55). Cox multivariate survival analysis revealed that PD1 + CTLA4 did not prolong PFS and OS (PFS: hazard ratio 0.83, 95% confidence interval 0.58-1.19, P = 0.30; OS: HR 0.89, 95% confidence interval 0.57-1.38, P = 0.59). The rate of ≥grade 3 immune-related adverse events was higher in the PD1 + CTLA4 group than in the PD1 group (53% versus 17%; P < 0.001). Conclusions First-line PD1 + CTLA4 demonstrated comparable clinical efficacy to PD1 in Japanese MCM patients, but with a higher rate of immune-related adverse events., Highlights • Anti-PD-1 plus anti-CTLA-4 antibody therapy (PD1 + CTLA4) is an option for patients with advanced mucosal melanoma (MCM). • Data on the efficacy of PD1 + CTLA4 compared with PD-1 monotherapy (PD1) for MCM, however, are limited. • We retrospectively analyzed data from 329 Japanese patients with advanced MCM treated with PD1 or PD1 + CTLA4. • No significant differences in objective response rate, progression-free survival, or overall survival were observed. • Immune-related adverse events resulting in treatment cessation were higher in the PD1 + CTLA4 group.

Published
2021
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17. POS0516 REDEFINING THE CLINICAL AND LABORATORY FEATURES OF RHEUMATIC PLEURAL EFFUSION: A 30-CASE SERIES

Author

Hiroyasu Ishimaru, Yoichi Nakayama, S. Matsushita, Ryuichi Sada, S. Minoda, Hiroyuki Akebo, Kazuhiro Hatta, and Yukio Tsugihashi

Subjects
medicine.medical_specialty, Rheumatology, Pleural effusion, business.industry, Immunology, medicine, Immunology and Allergy, Radiology, medicine.disease, business, General Biochemistry, Genetics and Molecular Biology
Abstract

Background:Rheumatoid pleural effusion (RPE) is a common extra-articular complication in patients with rheumatoid arthritis (RA). Previous studies have shown that RPE usually occurs in middle-aged men with rheumatoid factor (RF)-positive RA. RPE usually has features of pleural fluid acidosis, high lactate dehydrogenase (LDH) levels, and very low glucose levels(1). However, to the best of our knowledge, these findings were based on very few case series and reports, and most of these reports were published by the early 2000s(1, 2).Objectives:To investigate the clinical and laboratory characteristics and typical clinical courses of patients with RPE in a single centre of Japan since the beginning of the 21st century.Methods:Medical records of RPE patients were retrospectively reviewed between May 2006 and September 2020. RPE was identified by fulfilling these five conditions: (1) confirmation of the RA diagnosis; (2) having an exudative pleural effusion according to Light’s criteria; (3) negative results of pleural fluid culture; (4) negative results of pleural fluid cytology; and (5) exclusion of a parapneumonic effusion or empyema defined as no antibiotic use or ineffectiveness of antibiotics during the clinical course. Patients were divided into two groups according to their age at diagnosis: Results:A total of 30 cases of RPE were included in the study. The median age was 71 years (interquartile range [IQR], 66–78 years). Of these patients, 16 (53%) were women. The median disease duration of RA was 98 months (IQR, 8–162 months). The two groups comprised six patients aged vs. 3 months, p=0.008). Compared with Group A, Group B had fewer patients with fever (14% vs. 83%, p=0.003), and had lower serum C-reactive protein levels (3.3 vs. 11.1 mg/dL, p=0.03). Moreover, Group B was more likely to show mild inflammatory pleural fluids with higher pH (7.5 vs. 7.2, p=0.005) and lower LDH levels (155 vs. 1810 IU/L, p=0.046). Corticosteroids were started or increased in five (83%) and nine (38%) patients, and biologic disease-modifying anti-rheumatic drugs were started in one (17%) and two (8%) patients in groups A and B, respectively. One patient (16%) died within 5-years in Group A, and seven patients (29%) died in Group B.Conclusion:In contrast to previous studies, RPE was seen in older patients as well as middle-aged adults, and the pleural fluid analysis in older patients with RPE showed milder inflammation than the middle-aged patients.References:[1]Balbir-Gurman A, et al. Semin Arthritis Rheum. 2006 Jun; 35(6): 368-78.[2]Faurschou P, et al. Thorax. 1985 May; 40(5): 371-5.Table 1.Comparison of clinical and laboratory findings between Group A and Group B.Group A (n=6)Group B (n=24)P valueAge (years)54 [49-56]74 [69-78]Female2 (n=6, 33.3)14 (n=24, 58.3)0.38Disease duration of RA (months)3 [1-9]132 [44-199]0.008Fever ≥37.0°C5 (n=6, 83.3)3 (n=22, 13.6)0.003SerumCRP (mg/dL)11.1 [5.6-1.4]3.3 [0.9-10.5]0.03 RF (IU/mL)100 [19-816]63 [23-193]0.95 Anti-CCP ab positive5 (n=6, 83.3)12 (n=15, 80)1.00Pleural fluid analysispH7.2 [7.2-7.2]7.5 [7.4-7.5]0.005LDH (IU/L)1810 [594-2932]155 [123-346]0.046Glu (mg/dL)59 [10-123]105 [91-122]0.42Tp (g/dL)5.1 [4.9-5.6]4.6 [3.6-5.2]0.21Number of cells (/μL)5235 [3353-9300]3300 [1490-5008]0.27 Glu/serum Glu0.41 [0.09-0.99]1.05 [0.85-1.15]0.71Started or increased CS5 (n=6, 83.3)9 (n=24, 37.5)0.18Started bDMARDs1 (n=6, 16.6)2 (n=24, 8.3)0.50Died within 5 years1 (n=6, 16.6)7 (n=24, 29.1)1.00Data are median [interquartile range], or number (total number, percent).Abbreviations: RA, rheumatoid arthritis; CRP, C-reactive protein; RF, rheumatoid factor; Anti-CCP ab, anti-cyclic citrullinated peptide antibodies; LDH, lactate dehydrogenase; Glu, glucose; Tp, total protein; CS, corticosteroid; bDMARDs, biologic disease-modifying anti-rheumatic drugsDisclosure of Interests:None declared

Published
2021
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18. Measurement of the production cross section for single top quarks in association with W bosons in proton-proton collisions at root s=13 TeV

Author

Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Asilar, E. Bergauer, T. Brandstetter, J. Brondolin, E. and Dragicevic, M. Eroe, J. Del Valle, A. Escalante Flechl, M. and Friedl, M. Ghete, V. M. Hrubec, J. Jeitler, M. and Krammer, N. Kraetschmer, I. Liko, D. Madlener, T. and Mikulec, I. Rad, N. Rohringer, H. Schieck, J. and Schoefbeck, R. Spanring, M. Spitzbart, D. Taurok, A. and Waltenberger, W. Wittmann, J. Wulz, C. -E. Zarucki, M. and Chekhovsky, V. Mossolov, V. Gonzalez, J. Suarez De Wolf, E. A. Di Croce, D. Janssen, X. Lauwers, J. Pieters, M. and Van de Klundert, M. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Abu Zeid, S. Blekman, F. D'Hondt, J. De Bruyn, I. De Clercq, J. Deroover, K. Flouris, G. and Lontkovskyi, D. Lowette, S. Marchesini, I. Moortgat, S. and Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. Beghin, D. and Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. and Delannoy, H. Dorney, B. Fasanella, G. Favart, L. and Goldouzian, R. Grebenyuk, A. Kalsi, A. K. Lenzi, T. and Luetic, J. Seva, T. Starling, E. Vander Velde, C. and Vanlaer, P. Vannerom, D. Cornelis, T. Dobur, D. Fagot, A. Gul, M. Khvastunov, I. Poyraz, D. Roskas, C. and Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. and Zaganidis, N. Bakhshiansohi, H. Bondu, O. Brochet, S. and Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. Francois, B. Giammanco, A. Krintiras, G. Lemaitre, V. and Magitteri, A. Mertens, A. Musich, M. Piotrzkowski, K. and Saggio, A. Marono, M. Vidal Wertz, S. Zobec, J. Alda Junior, W. L. Alves, F. L. Alves, G. A. Brito, L. and Correia Silva, G. Hensel, C. Moraes, A. Pol, M. E. and Rebello Teles, P. Belchior Batista Das Chagas, E. Carvalho, W. and Chinellato, J. Coelho, E. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Malbouisson, H. Medina Jaime, M. Melo De Almeida, M. Mora Herrera, C. and Mundim, L. Nogima, H. Sanchez Rosas, L. J. Santoro, A. and Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. and Romero Abad, D. Ruiz Vargas, J. C. Aleksandrov, A. and Hadjiiska, R. Iaydjiev, P. Marinov, A. Misheva, M. and Rodozov, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Fang, W. Gao, X. Yuan, L. and Ahmad, M. Bian, J. G. Chen, G. M. Chen, H. S. Chen, M. Chen, Y. Jiang, C. H. Leggat, D. Liao, H. Liu, Z. and Romeo, F. Shaheen, S. M. Spiezia, A. Tao, J. Wang, C. Wang, Z. Yazgan, E. Zhang, H. Zhao, J. Ban, Y. and Chen, G. Li, J. Li, Q. Liu, S. Mao, Y. Qian, S. J. Wang, D. Xu, Z. Wang, Y. Avila, C. Cabrera, A. and Carrillo Montoya, C. A. Chaparro Sierra, L. F. Florez, C. and Gonzalez Hernandez, C. F. Segura Delgado, M. A. Courbon, B. and Godinovic, N. Lelas, D. Puljak, I. Sculac, T. and Antunovic, Z. Kovac, M. Brigljevic, V. Ferencek, D. and Kadija, K. Mesic, B. Starodumov, A. Susa, T. Ather, M. W. Attikis, A. Mavromanolakis, G. Mousa, J. Nicolaou, C. and Ptochos, F. Razis, P. A. Rykaczewski, H. Finger, M. and Finger, Jr., M. Carrera Jarrin, E. Elgammal, S. Mohamed, A. and Salama, E. Bhowmik, S. De Oliveira, A. Carvalho Antunes and Dewanjee, R. K. Kadastik, M. Perrini, L. Raidal, M. and Veelken, C. Eerola, P. Kirschenmann, H. Pekkanen, J. and Voutilainen, M. Havukainen, J. Heikkila, J. K. Jarvinen, T. and Karimaki, V. Kinnunen, R. Lampen, T. Lassila-Perini, K. and Laurila, S. Lehti, S. Linden, T. Luukka, P. Maenpaa, T. Siikonen, H. Tuominen, E. Tuominiemi, J. Tuuva, T. and Besancon, M. Couderc, F. Dejardin, M. Denegri, D. and Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel Jarry, P. Leloup, C. Locci, E. Machet, M. Malcles, J. Negro, G. Rander, J. and Rosowsky, A. Sahin, M. O. Titov, M. Abdulsalam, A. and Amendola, C. Antropov, I. Baffioni, S. Beaudette, F. and Busson, P. Cadamuro, L. Charlot, C. de Cassagnac, R. Granier and Jo, M. Kucher, I. Lisniak, S. Lobanov, A. Martin Blanco, J. Nguyen, M. Ochando, C. Ortona, G. Paganini, P. Pigard, P. Salerno, R. Sauvan, J. B. Sirois, Y. and Stahl Leiton, A. G. Yilmaz, Y. Zabi, A. Zghiche, A. and Agram, J. -L. Andrea, J. Bloch, D. Brom, J. -M. Chabert, E. C. Collard, C. Conte, E. Drouhin, F. Fontaine, J. -C. and Gele, D. Goerlach, U. Jansova, M. Juillot, P. Le Bihan, A. -C. Tonon, N. Van Hove, P. Gadrat, S. and Beauceron, S. Bernet, C. Boudoul, G. Chanon, N. and Chierici, R. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Finco, L. Gascon, S. Gouzevitch, M. Grenier, G. and Ille, B. Lagarde, F. Laktineh, I. B. Lattaud, H. and Lethuillier, M. Mirabito, L. Pequegnot, A. L. Perries, S. and Popov, A. Sordini, V. Vander Donckt, M. Viret, S. and Zhang, S. Khvedelidze, A. Tsamalaidze, Z. Autermann, C. and Feld, L. Kiesel, M. K. Klein, K. Lipinski, M. Preuten, M. Rauch, M. P. Schomakers, C. Schulz, J. Teroerde, M. and Wittmer, B. Zhukov, V. Albert, A. Duchardt, D. and Endres, M. Erdmann, M. Erdweg, S. Esch, T. Fischer, R. and Ghosh, S. Gueth, A. Hebbeker, T. Heidemann, C. and Hoepfner, K. Knutzen, S. Mastrolorenzo, L. Merschmeyer, M. and Meyer, A. Millet, P. Mukherjee, S. Pook, T. Radziej, M. Reithler, H. Rieger, M. Scheuch, F. Schmidt, A. and Teyssier, D. Thueer, S. Fluegge, G. Hlushchenko, O. and Kargoll, B. Kress, T. Kuensken, A. Mueller, T. Nehrkorn, A. Nowack, A. Pistone, C. Pooth, O. Sert, H. Stahl, A. Aldaya Martin, M. Arndt, T. Asawatangtrakuldee, C. and Babounikau, I. Beernaert, K. Behnke, O. Behrens, U. and Martinez, A. Bermudez Bertsche, D. Bin Anuar, A. A. Borras, K. Botta, V. Campbell, A. Connor, P. Contreras-Campana, C. Costanza, F. Danilov, V. De Wit, A. Defranchis, M. M. and Diez Pardos, C. Dominguez Damiani, D. Eckerlin, G. and Eckstein, D. Eichhorn, T. Elwood, A. Eren, E. Gallo, E. and Geiser, A. Grados Luyando, J. M. Grohsjean, A. and Gunnellini, P. Guthoff, M. Harb, A. Hauk, J. Jung, H. and Kasemann, M. Keaveney, J. Kleinwort, C. Knolle, J. and Kruecker, D. Lange, W. Lelek, A. Lenz, T. Lipka, K. and Lohmann, W. Mankel, R. Melzer-Pellmann, I. -A. Meyer, A. B. and Meyer, M. Missiroli, M. Mittag, G. Mnich, J. and Mussgiller, A. Pflitsch, S. K. Pitzl, D. Raspereza, A. and Savitskyi, M. Saxena, P. Schuetze, P. Schwanenberger, C. and Shevchenko, R. Singh, A. Stefaniuk, N. Tholen, H. and Vagnerini, A. Van Onsem, G. P. Walsh, R. Wen, Y. and Wichmann, K. Wissing, C. Zenaiev, O. Aggleton, R. Bein, S. Benecke, A. Blobel, V. Centis Vignali, M. Dreyer, T. and Garutti, E. Gonzalez, D. Haller, J. Hinzmann, A. and Hoffmann, M. Karavdina, A. Kasieczka, G. Klanner, R. and Kogler, R. Kovalchuk, N. Kurz, S. Kutzner, V. Lange, J. and Marconi, D. Multhaup, J. Niedziela, M. Nowatschin, D. and Peiffer, T. Perieanu, A. Reimers, A. Rieger, O. and Scharf, C. Schleper, P. Schumann, S. Schwandt, J. and Sonneveld, J. Stadie, H. Steinbrueck, G. Stober, F. 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I. and Bencze, G. Hajdu, C. Horvath, D. Hunyadi, A. Sikler, F. and Vami, T. A. Veszpremi, V. Vesztergombi, G. Beni, N. and Czellar, S. Karancsi, J. Makovec, A. Molnar, J. and Szillasi, Z. Bartok, M. Raics, P. Trocsanyi, Z. L. and Ujvari, B. Choudhury, S. Komaragiri, J. R. Bahinipati, S. and Mal, P. Mandal, K. Nayak, A. Sahoo, D. K. Swain, S. K. Bansal, S. Beri, S. B. Bhatnagar, V. Chauhan, S. and Chawla, R. Dhingra, N. Gupta, R. Kaur, A. Kaur, M. and Kaur, S. Kumar, R. Kumari, P. Lohan, M. Mehta, A. and Sharma, S. Singh, J. B. Walia, G. Bhardwaj, A. and Choudhary, B. C. Garg, R. B. Keshri, S. Kumar, A. Kumar, Ashok Malhotra, S. Naimuddin, M. Priyanka, P. Ranjan, K. and Shah, Aashaq Sharma, R. Bhardwaj, R. Bharti, M. and Bhattacharya, R. Bhattacharya, S. Bhawandeep, U. Bhowmik, D. and Dey, S. Dutt, S. Dutta, S. Ghosh, S. Majumdar, N. and Mondal, K. Mukhopadhyay, S. Nandan, S. Purohit, A. and Rout, P. K. Roy, A. Roy Chowdhury, S. Sarkar, S. Sharan, M. Singh, B. Thakur, S. Behera, P. K. 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T. Beretvas, A. Berryhill, J. Bhat, P. C. and Bolla, G. Burkett, K. Butler, J. N. Canepa, A. and Cerati, G. B. Cheung, H. W. K. Chlebana, F. Cremonesi, M. and Duarte, J. Elvira, V. D. Freeman, J. Gecse, Z. and Gottschalk, E. Gray, L. Green, D. Grunendahl, S. and Gutsche, O. Hanlon, J. Harris, R. M. Hasegawa, S. and Hirschauer, J. Hu, Z. Jayatilaka, B. Jindariani, S. and Johnson, M. Joshi, U. Klima, B. Kortelainen, M. J. and Kreis, B. Lammel, S. Lincoln, D. Lipton, R. Liu, M. and Liu, T. De Sa, R. Lopes Lykken, J. Maeshima, K. Magini, N. Marraffino, J. M. Mason, D. McBride, P. Merkel, P. and Mrenna, S. Nahn, S. O'Dell, V. Pedro, K. Prokofyev, O. Rakness, G. Ristori, L. Savoy-Navarro, A. Schneider, B. Sexton-Kennedy, E. Soha, A. Spalding, W. J. Spiegel, L. Stoynev, S. Strait, J. Strobbe, N. Taylor, L. and Tkaczyk, S. Tran, N. V. Uplegger, L. Vaandering, E. W. and Vernieri, C. Verzocchi, M. Vidal, R. Wang, M. Weber, H. A. Whitbeck, A. Wu, W. Acosta, D. Avery, P. and Bortignon, P. Bourilkov, D. Brinkerhoff, A. Carnes, A. and Carver, M. Curry, D. Field, R. D. Furic, I. K. Gleyzer, S. V. Joshi, B. M. Konigsberg, J. Korytov, A. Kotov, K. and Ma, P. Matchev, K. Mei, H. Mitselmakher, G. Shi, K. and Sperka, D. Terentyev, N. Thomas, L. Wang, J. Wang, S. Yelton, J. Joshi, Y. R. Linn, S. Markowitz, P. and Rodriguez, J. L. Ackert, A. Adams, T. Askew, A. and Hagopian, S. Hagopian, V. Johnson, K. F. Kolberg, T. and Martinez, G. Perry, T. Prosper, H. Saha, A. Santra, A. and Sharma, V. Yohay, R. Baarmand, M. M. Bhopatkar, V. and Colafranceschi, S. Hohlmann, M. Noonan, D. Roy, T. and Yumiceva, F. Adams, M. R. Apanasevich, L. Berry, D. and Betts, R. R. Cavanaugh, R. Chen, X. Dittmer, S. and Evdokimov, O. Gerber, C. E. Hangal, D. A. Hofman, D. J. and Jung, K. Kamin, J. Mills, C. Gonzalez, I. D. Sandoval and Tonjes, M. B. Varelas, N. Wang, H. Wu, Z. Zhang, J. and Bilki, B. Clarida, W. Dilsiz, K. Durgut, S. Gandrajula, R. P. Haytmyradov, M. Khristenko, V. Merlo, J. -P. and Mermerkaya, H. Mestvirishvili, A. Moeller, A. Nachtman, J. and Ogul, H. Onel, Y. Ozok, F. Penzo, A. Snyder, C. and Tiras, E. Wetzel, J. Yi, K. Blumenfeld, B. Cocoros, A. and Eminizer, N. Fehling, D. Feng, L. Gritsan, A. V. and Hung, W. T. Maksimovic, P. Roskes, J. Sarica, U. Swartz, M. Xiao, M. You, C. Al-bataineh, A. Baringer, P. and Bean, A. Benitez, J. F. Boren, S. Bowen, J. Castle, J. and Khalil, S. Kropivnitskaya, A. Majumder, D. Mcbrayer, W. and Murray, M. Rogan, C. Royon, C. Sanders, S. Schmitz, E. Takaki, J. D. Tapia Wang, Q. Ivanov, A. Kaadze, K. and Maravin, Y. Modak, A. Mohammadi, A. Saini, L. K. and Skhirtladze, N. Rebassoo, F. Wright, D. Baden, A. Baron, O. Belloni, A. Eno, S. C. Feng, Y. Ferraioli, C. and Hadley, N. J. Jabeen, S. Jeng, G. Y. Kellogg, R. G. and Kunkle, J. Mignerey, A. C. Ricci-Tam, F. Shin, Y. H. and Skuja, A. Tonwar, S. C. Abercrombie, D. Allen, B. and Azzolini, V. Barbieri, R. Baty, A. Bauer, G. Bi, R. and Brandt, S. Busza, W. Cali, I. A. D'Alfonso, M. and Demiragli, Z. Ceballos, G. Gomez Goncharov, M. Harris, P. and Hsu, D. Hu, M. Iiyama, Y. Innocenti, G. M. Klute, M. and Kovalskyi, D. Lee, Y. -J. Levin, A. Luckey, P. D. and Maier, B. Marini, A. C. Mcginn, C. Mironov, C. and Narayanan, S. Niu, X. Paus, C. Roland, C. Roland, G. and Stephans, G. S. F. Sumorok, K. Tatar, K. Velicanu, D. and Wang, J. Wang, T. W. Wyslouch, B. Zhaozhong, S. and Benvenuti, A. C. Chatterjee, R. M. Evans, A. Hansen, P. and Kalafut, S. Kubota, Y. Lesko, Z. Mans, J. Nourbakhsh, S. and Ruckstuhl, N. Rusack, R. Turkewitz, J. Wadud, M. A. and Acosta, J. G. Oliveros, S. Avdeeva, E. Bloom, K. Claes, D. R. Fangmeier, C. Golf, F. Suarez, R. Gonzalez and Kamalieddin, R. Kravchenko, I. Monroy, J. Siado, J. E. and Snow, G. R. Stieger, B. Godshalk, A. Harrington, C. and Iashvili, I. Nguyen, D. Parker, A. Rappoccio, S. and Roozbahani, B. Alverson, G. Barberis, E. Freer, C. and Hortiangtham, A. Massironi, A. Morse, D. M. Orimoto, T. and De Lima, R. Teixeira Wamorkar, T. Wang, B. Wisecarver, A. and Wood, D. Bhattacharya, S. Charaf, O. Hahn, K. A. and Mucia, N. Odell, N. Schmitt, M. H. Sung, K. Trovato, M. and Velasco, M. Bucci, R. Dev, N. Hildreth, M. Anampa, K. Hurtado Jessop, C. Karmgard, D. J. Kellams, N. and Lannon, K. Li, W. Loukas, N. Marinelli, N. Meng, F. and Mueller, C. Musienko, Y. Planer, M. Reinsvold, A. and Ruchti, R. Siddireddy, P. Smith, G. Taroni, S. Wayne, M. and Wightman, A. Wolf, M. Woodard, A. Alimena, J. and Antonelli, L. Bylsma, B. Durkin, L. S. Flowers, S. and Francis, B. Hart, A. Hill, C. Ji, W. Ling, T. Y. and Luo, W. Winer, B. L. Wulsin, H. W. Cooperstein, S. and Driga, O. Elmer, P. Hardenbrook, J. Hebda, P. and Higginbotham, S. Kalogeropoulos, A. Lange, D. Luo, J. and Marlow, D. Mei, K. Ojalvo, I. Olsen, J. Palmer, C. and Piroue, P. Salfeld-Nebgen, J. Stickland, D. Tully, C. and Malik, S. Norberg, S. Barker, A. Barnes, V. E. Das, S. and Gutay, L. Jones, M. Jung, A. W. Khatiwada, A. and Miller, D. H. Neumeister, N. Peng, C. C. Qiu, H. and Schulte, J. F. Sun, J. Wang, F. Xiao, R. Xie, W. and Cheng, T. Dolen, J. Parashar, N. Chen, Z. Ecklund, K. M. and Freed, S. Geurts, F. J. M. Guilbaud, M. Kilpatrick, M. and Li, W. Michlin, B. Padley, B. P. Roberts, J. Rorie, J. Shi, W. Tu, Z. Zabel, J. Zhang, A. Bodek, A. and de Barbaro, P. Demina, R. Duh, Y. t. Ferbel, T. Galanti, M. Garcia-Bellido, A. Han, J. Hindrichs, O. and Khukhunaishvili, A. Lo, K. H. Tan, P. Taus, R. Verzetti, M. Ciesielski, R. Goulianos, K. Mesropian, C. Agapitos, A. Chou, J. P. Gershtein, Y. Espinosa, T. A. Gomez and Halkiadakis, E. Heindl, M. Hughes, E. Kaplan, S. and Elayavalli, R. Kunnawalkam Kyriacou, S. Lath, A. Montalvo, R. Nash, K. Osherson, M. Saka, H. Salur, S. and Schnetzer, S. Sheffield, D. Somalwar, S. Stone, R. and Thomas, S. Thomassen, P. Walker, M. Delannoy, A. G. and Heideman, J. Riley, G. Rose, K. Spanier, S. Thapa, K. and Bouhali, O. Hernandez, A. Castaneda Celik, A. Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. Eusebi, R. and Gilmore, J. Huang, T. Kamon, T. Mueller, R. Pakhotin, Y. and Patel, R. Perloff, A. Pernie, L. Rathjens, D. and Safonov, A. Tatarinov, A. Akchurin, N. Damgov, J. De Guio, F. Dudero, P. R. Faulkner, J. Kunori, S. and Lamichhane, K. Lee, S. W. Mengke, T. Muthumuni, S. and Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. Greene, S. Gurrola, A. Janjam, R. Johns, W. Maguire, C. and Melo, A. Ni, H. Padeken, K. Alvarez, J. D. Ruiz Sheldon, P. Tuo, S. Velkovska, J. Xu, Q. Arenton, M. W. and Barria, P. Cox, B. Hirosky, R. Joyce, M. Ledovskoy, A. and Li, H. Neu, C. Sinthuprasith, T. Wang, Y. Wolfe, E. and Xia, F. Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Brodski, M. Buchanan, J. and Caillol, C. Carlsmith, D. Dasu, S. Dodd, L. Duric, S. and Gomber, B. Grothe, M. Herndon, M. Herve, A. Hussain, U. Klabbers, P. Lanaro, A. Levine, A. Long, K. and Loveless, R. Rekovic, V. Ruggles, T. Savin, A. Smith, N. and Smith, W. H. Woods, N. CMS Collaboration

Subjects
High Energy Physics::Experiment, Nuclear Experiment
Abstract

A measurement is presented of the associated production of a single top quark and a W boson in proton -proton collisions at root s = 13 TeV by the CMS Collaboration at the CERN LHC. The data collected corresponds to an integrated luminosity of 35.9 fb(-1). The measurement is performed using events with one electron and one muon in the final state along with at least one jet originated from a bottom quark. A multivariate discriminant, exploiting the kinematic properties of the events, is used to separate the signal from the dominant tt background. The measured cross section of 63.1 +/- 1.8(stat) +/- 6.4(syst) +/- 2.1 (lumi) pb is in agreement with the standard model expectation.

Published
2018

19. Irrigation Water Management and Livelihood System of Farm Households: A Case Study of Improved and Unimproved Irrigation System Areas in the Northern Delta

Author

M. Nawar, S. Matsushita, and A. T. Elbendary

Subjects
Delta, Irrigation, Geography, Agriculture, business.industry, Irrigation statistics, Sample (statistics), Irrigation management, Livelihood, Water resource management, business, Socioeconomic status, Agricultural economics
Abstract

Irrigation improvement projects in Egypt intended to modernize irrigation systems include organizational changes in the management of irrigation by farmers. This chapter, from the socioeconomic point of view, aims to clarify and compare the state of farmers in two different areas equipped with improved and unimproved (traditional) irrigation systems. Two branch irrigation canals were selected for the study; the improved Bahr El Nour and traditional Abshan canals in the Beila District, Kafr El-Sheikh governorate, one of the major paddy production regions. This study examined the potential livelihood outcomes by devising a typology of farming/household systems including biophysical characteristics, respondents’ socioeconomic characteristics and coping strategies in the two areas. A sample of 400 farmer respondents, 200 from each area, was selected using the multi-stage random sampling procedure. The results indicated that the differences between the two areas are based on several structural variables. Regardless of the issue of irrigation efficiency, access to the land and other material resources is still the most influential issue in determining the livelihood of farm households.

Published
2017
Full Text
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21. Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation

Author

Hisanori Takenobu, K Nakashima, Osamu Shimozato, Hideki Yamamoto, N Kubo, Takehiko Kamijo, Hiroaki Souda, S Matsushita, Toshinori Ozaki, M Waraya, Nobuhiro Takiguchi, H Uehara, Akira Nakagawara, and E Ikeda

Subjects
Cancer Research, Mice, Nude, Protein tyrosine phosphatase, Biology, Dephosphorylation, Mice, chemistry.chemical_compound, fluids and secretions, Antigens, CD, Genetics, Animals, Humans, AC133 Antigen, Phosphorylation, Tyrosine, neoplasms, Molecular Biology, Protein kinase B, beta Catenin, Cell Proliferation, Glycoproteins, Mice, Inbred BALB C, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Tyrosine phosphorylation, carbohydrates (lipids), Receptor-Like Protein Tyrosine Phosphatases, chemistry, Colonic Neoplasms, embryonic structures, Neoplastic Stem Cells, cardiovascular system, Cancer research, Heterografts, Caco-2 Cells, Signal transduction, Peptides, HT29 Cells, Proto-Oncogene Proteins c-akt, Signal Transduction
Abstract

Although CD133 has been considered to be a molecular marker for cancer stem cells, its functional roles in tumorigenesis remain unclear. We here examined the molecular basis behind CD133-mediated signaling. Knockdown of CD133 resulted in the retardation of xenograft tumor growth of colon cancer-derived HT-29 and LoVo cells accompanied by hypophosphorylation of AKT, which diminished β-catenin/T-cell factor-mediated CD44 expression. As tyrosine residues of CD133 at positions 828 and 852 were phosphorylated in HT-29 and SW480 cells, we further addressed the significance of this phosphorylation in the tumorigenesis of SW480 cells expressing mutant CD133, with substitution of these tyrosine residues by glutamate (CD133-EE) or phenylalanine (CD133-FF). Forced expression of CD133-EE promoted much more aggressive xenograft tumor growth relative to wild-type CD133-expressing cells accompanied by hyperphosphorylation of AKT; however, CD133-FF expression had negligible effects on AKT phosphorylation and xenograft tumor formation. Intriguingly, the tyrosine phosphorylation status of CD133 was closely linked to the growth of SW480-derived spheroids. Using yeast two-hybrid screening, we finally identified receptor-type protein tyrosine phosphatase κ (PTPRK) as a binding partner of CD133. In vitro studies demonstrated that PTPRK associates with the carboxyl-terminal region of CD133 through its intracellular phosphatase domains and also catalyzes dephosphorylation of CD133 at tyrosine-828/tyrosine-852. Silencing of PTPRK elevated the tyrosine phosphorylation of CD133, whereas forced expression of PTPRK reduced its phosphorylation level markedly and abrogated CD133-mediated AKT phosphorylation. Endogenous CD133 expression was also closely associated with higher AKT phosphorylation in primary colon cancer cells, and ectopic expression of CD133 enhanced AKT phosphorylation. Furthermore, lower PTPRK expression significantly correlated with the poor prognosis of colon cancer patients with high expression of CD133. Thus, our present findings strongly indicate that the tyrosine phosphorylation of CD133, which is dephosphorylated by PTPRK, regulates AKT signaling and has a critical role in colon cancer progression.

Published
2014
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22. Physics of Geomagnetic Phenomena : International Geophysics Series, Vol. 2

Author

S. Matsushita, Wallace H. Campbell, S. Matsushita, and Wallace H. Campbell

Subjects
Geomagnetism
Abstract

Physics of Geomagnetic Phenomena, Volume II covers the advances in geomagnetism and the penetrations into the generation of geomagnetic field phenomena. This book is composed of three chapters and begins with a discussion on various types of phenomenal disturbances, such as ionospheric and geomagnetic disturbance, aurora, and storm. The next chapter describes certain aspects of space geomagnetism based on satellite and rocket observations. This chapter also examines the origins of geomagnetic disturbance phenomena. The last chapter surveys the problems connected with studies of geomagnetic storms and auroras, along with a hydromagnetic model of these phenomena. This book will be of value to physicists, theoreticians, and scientists in allied fields of geomagnetism.

Published
2016

23. Physics of Geomagnetic Phenomena : International Geophysics Series, Vol. 1

Author

S. Matsushita, Wallace H. Campbell, S. Matsushita, and Wallace H. Campbell

Subjects
Geomagnetism
Abstract

Physics of Geomagnetic phenomena, Volume I covers the significant advances in geomagnetism and the penetrations into the generation of geomagnetic field phenomena. This volume is composed of three chapters. Chapter I deals briefly with the discovery and developments in geomagnetism, followed by discussions on some fundamental topics of the field, including the aurora and geomagnetic storms. This chapter also considers the instruments, geomagnetic stations, and the correlations between geomagnetic indices. Chapter II describes the magnetic properties of minerals and various processes of acquisition of remanent magnetization. This chapter also provides palaeomagnetic data for the direction and intensity of the geomagnetic field in ancient times. Chapter III explores geomagnetic variations caused by solar flares and eclipses. This book will prove useful to physicists, students in upper atmospheric and space topics, and scientists in allied fields with a background in geomagnetism.

Published
2016

24. Epispadias and the associated embryopathies: genetic and developmental basis

Author

K, Suzuki, D, Matsumaru, S, Matsushita, A, Murashima, M, Ludwig, H, Reutter, and G, Yamada

Subjects
Disease Models, Animal, Fetal Diseases, Mice, Epispadias, Urogenital Abnormalities, Bladder Exstrophy, Animals, Embryonic Development, Humans, Congenital Abnormalities
Abstract

The abnormalities in the urogenital organs are frequently observed as human developmental diseases. Among such diseases, the defects in the upper part of external genitalia are rather rare named epispadias. The cleft in the dorsal part of external genitalia often reaches to the urethra. In general, the urogenital abnormalities accompany defects in the adjacent tissues and organs. The ventral body wall and bladder can also be affected in the patients with dorsal defects of the external genitalia. Therefore, such multiple malformations are often classified as bladder exstrophy and epispadias complex (BEEC). Because of the lower frequency of such birth defects and their early embryonic development, animal models are required to analyze the pathogenic mechanisms and the functions of responsible genes. Mutant mouse analyses on various signal cascades for external genitalia and body wall development are increasingly performed. The genetic interactions between growth factors such as bone morphogenetic proteins (Bmp) and transcription factors such as Msx1/2 and Isl1 have been suggested to play roles for such organogenesis. The significance of epithelial-mesenchymal interaction (EMI) is suggested during development. In this review, we describe on such local interactions and developmental regulators. We also introduce some mutant mouse models displaying external genitalia-body wall abnormalities.

Published
2016

26. Poster session Friday 7 December - PM: Effect of systemic illnesses on the heart

Author

G. Forleo, T. Henriques-Coelho, A. Kalogerakis, A. Nestoruc, R. Conti, G. Guzman Martinez, M. Ostojic, S. Aytekin, P. Margetis, D. Kremastinos, A. Hagege, M. Sunbul, L. Hazarapetyan, M. Fernandes, A. Pfuetzner, M. Akkaya, I. Paraskevaides, C. Zito, F. Castillo, D. G. Dorado, A Di Cori, O. Azevedo, M. Pizzarelli, TM Li Causi, A. Jaccard, A. Chilingaryan, A. Lourenco, B. Mutlu, E. Ermis, M. Martinek, D. Duval, L. Tumasyan, J. Thambo, P. Virot, P. De Araujo Goncalves, I. Sari, F. Colazzo, A. Stepura, M. S. Carvalho, B. Beleslin, P. Nihoyannopoulos, A. Corciu, E. Langesaeter, F. Kyndt, J. Schott, A. Diogo, G. Andersen, D. De Palma, H. Skulstad, P. Crea, S. Wirdeier, M. Olszowska, S. Castelvecchio, M. Muiesan, M. Kalantzi, G. Ertas, K. Branidou, I. Alvarez Pichel, E. Shkolnik, T. Schuster, M. J. Monaghan, A. Parkhomenko, V. Schiano Lomoriello, A. Ahmed, C. Jimenez Rubio, M. M. Urdaniz, A. M. Lesniak-Sobelga, G. Rubagotti, S. Gustavsson, Verena Stangl, F. Bertacchini, J. Otterstad, S. Matsushita, G. Macri, W. Streb, C. David, Y. Nogami, L. Faber, J. Kim, M. Chigira, M. Cusma-Piccione, S.-H. Shin, Cristina Maria Stanescu, M. Hlawaty, C. Napolitano, T. Kaier, S. Yurdakul, A. E. Masip, A. Zacharaki, S. Adawi, L. Menicanti, L. Tomkiewicz-Pajak, A. Patrianakos, S. Ercan, J. Stepanovic, F. Matei, U. Richter, E. Erdogan, R. Shaikh, A. Kepez, E. Soldati, K. Jarosz, M. Miceli, J. Grapsa, M. Cardoso, L. Boubrit, J. Singelton, M. Morenate, Henryk Dreger, I. Comanescu, L. Fontana, S. Morner, C. Agabiti Rosei, L. Brodin, J. Vaskelyte, E. Hamodraka, K. Uno, Fabian Knebel, R. Petraco, M. Komeda, L. Weinert, I. Daha, A. Shiran, V. Stinziani, I. Asmer, F. Antonini-Canterin, L. Iliuta, M. Rosca, P. Lindqvist, N. Cortez-Dias, E. Mueller, Z. Katidis, Y. Vasyuk, P. Rubis, R. Jonkaitiene, J. G. Acosta Velez, S. Lafitte, K. Fox, T. Rakowski, C. Manisty, D. Stassaldi, R. Piazza, L. Spinelli, S. Han, R. Lang, L. Oreto, T. Le Tourneau, L. Li, J. Areias, R. Isnard, D. Silva, Karl Stangl, T. Kukulski, M. Gaspari, A. Tsatsopoulou, Miguel Mota Carmo, P. Pugliatti, A. Atsumi, J. Hammel, J. B. Rius, F. D'auria, O. Ozer, A. Comaglio, Giulio Zucchelli, R. Sicari, P. Claus, D. Horstkotte, A. Di Molfetta, J. De La Hera Galarza, P. Wathen, M. Ganaeem, E. Nyktari, G. Alongi, N. Hayashi, L. Castiglioni, C. El Hamel, A. Melidonis, Y. Seo, M. Cogne, C. Corros, F. Procaccio, L. Fresiello, T. Graven, D. De Guillebon, I. Machado, V. Mor-Avi, R. Rubinshtein, E. Durmus, A. Venkatesh, A. Paini, E. Truemper, A. Aleixo, A. Sahlen, C. Wunderlich, H. Uyarel, R. Ippolito, J. Huhta, D. Morgan, M. Petrovic, G. Cole, C. Piper, N. Zhuravskaya, J. Dubiel, R. Bloise, A. Iniesta Manjavacas, J. Kleinau, J. Lambert Rodriguez, E. Pasanisi, V. Petitalot, D. Beldekos, H. Lim, P. Kleczynski, N. Echahidi, K. Linask, A. Tasal, U. Guerrini, B. Haugen, V. Pereira, M. Banovic, A. Moreo, J. Miralles Ibarra, J F Rodriguez Palomares, C. Park, O. Mjolstad, R. Levine, M. T. G. Alujas, A. Zagatina, M. Martin Fernandez, J. Voigt, E. Psathakis, Y.-Y. Yang, B. Smith, A. Marciniak, T. Yoshikawa, M. Mohammed, C. Aggiusti, H. Tountas, M. Montoro Lopez, M. Guazzi, T. Przewlocki, D. Kim, A. Vannozzi, P. Kogoj, A. Kablak-Ziembicka, S. Goncalves, P. Heilmeyer, S. Censi, J. Kwan, S. Crispo, I. Nogueira, G. Isasti Aizpurua, F. Parthenakis, K. Sveric, O. Uku, F. Anglano, R. Jozwa, A. Karamanou, B. Ozben, M. Delgado, A. Santoro, A. Scafa Udriste, B. Vujisic-Tesic, Y. Kameda, L. Mathias, M. Bongiorni, S. Gianstefani, K.-S. Hsieh, J. Cousins, M. Prull, M. Isailovic-Kekovic, M. Turfan, J. Reiken, R. Muscariello, O. Fernandez Cimadevilla, E. Tremoli, S. Gherardi, F. Musca, S. Kutty, B. Popovic, D. Dudek, L. Gullestad, Michael Laule, A. Almeida, S. Vrakas, C. Santoro, M. Moreno Yanguela, V. Nesvetov, I. Lekakis, V. Mizariene, H. Yamagata, I. Karch, C. Davos, E. Stepien, E. A. Di Panzillo, C. Morisco, S. Kim, M. Takeuchi, R. Del Bene, A. Gaspar, C. Choi, M. Duprey, C. Cefalu, P. Regnier, Q. Ciampi, D. Francis, Gerd Baldenhofer, J. Trochu, A. Dziewierz, T. Bombardini, I. Nedeljkovic, O. Tautu, O. Suhr, M. Enomoto, K.-P. Weng, E. Enache, J. Johnson, J. Legutko, S. Grigoryan, R. Winter, J. Sousa, K. Aonuma, G. Wulf, S. Priori, J. Attebery, A. Squeri, S. Bosi, D. Lavergne, F. Bandera, P. T. Mas, X. Iriart, P. Vardas, A. Brzozowska-Czarnek, B. Trimarco, J. Kasprzak, K. Stuuer, R. Arena, J. O. Na, E. Picano, A. Horovitz, M. Sucu, M. Vatankulu, Vasile Manoliu, Z. Siudak, T. Damy, H. Dores, G. Tsaoussis, Gert Baumann, J. Jakala, Z. Kalarus, R. Jasaityte, G. Dan, K. Takenaka, M. Gurzun, M. Mavroidis, R. Florez Gomez, S. Winter, A. Ebihara, E. Fousteris, N. Catibog, B. Kilickiran Avci, A. Deligiorgis, R. Sharma, A. Alonso Ladreda, M. Dorobantu, Y. Lutay, P. Barbier, O. Jobard, J. Jedrzychowska-Baraniak, M. Perez-Lopez, Y. Yatomi, C. Itziar Soto, P. Polisca, K. Adamyan, B. Putnikovic, M. Lourenco, N. Taha, C. Ebner, K. Obase, P. Podolec, F. Romeo, M. Yamamoto, K. Shahgaldi, T. Edvardsen, C. Leon, A. Varela, A. Anastasakis, D. Oh, I. Di Matteo, A. Manouras, A. Theodosis-Georgilas, J. Bernstein, D. Cini, P. Reant, L. Santini, I. Quelhas, A. Bacaksiz, E. Agabiti Rosei, S. Bartosh-Zelenaya, R. Enache, C. Baicus, G. T. Tura, K. Kimura, R. Esposito, P. Kekovic, A. Whittaker, K. Park, N. Monteforte, S. Foussas, M. Kostkiewicz, S. Damjanovic, T. Ishizu, I. Ene, L. Chiariello, M. van Bracht, L. Segreti, T. Gaspar, A. Neves, M. Estensen, S. Carerj, H. Nesser, K. Yoshida, E. Prappa, S. Connolly, A. Djordjevic-Dikic, A. Calin, P. Carrilho-Ferreira, V. Di Bello, C. Beladan, S. Im, Sebastian Spethmann, S. Hakky, U. Trecroci, S. Tamai, L. Wrotniak, J. Necas, H. Marques, A. Neskovic, K. Skjetne, M. Galderisi, V. Ruddox, C. Adam, J. Leshko, H. Le Marec, A. Mateescu, L. Tunyan, F. Baeza, R. De Lucia, S. Aakhus, W. Serra, D. Simion, I. Stankovic, L. G. Garcia-Moreno, S. Sahin, P. Seferovic, M. Casartelli, E. Nobili, J. Marques, V. Davutoglu, O. Goktekin, C. Ginghina, D. Gemma, C. Yodwut, T. Sakakura, M. Nedeljkovic, S. Viani, H. Von Bibra, N. Protonotarios, R. Onut, H. Dalen, E. Romo, S. Woo, M. Franzosi, D. Zamfir, P. Ierano, J. S. De Lezo, E. Yeager, H.-J. Trappe, F. Pereira Machado, S. Grego, C. Gronlund, J. O'driscoll, C. Tsilafakis, L. Carpinteiro, L. Sironi, B. Diaz Molina, V. Probst, P. Sousa, N. Hammoudi, S. Kovalova, L. Paperini, M. Lunati, H. Seo, G. Ferrari, J. Roquette, F. Toledano, R. Jurkevicius, G. Nicolosi, D. Mohty, V. Giga, R. Sachner, T. Butz, F. Pousset, O. Sonmez, N. Reckefuss, O. Vriz, G. Dobson, J. Zdzienicka, V. Labate, F. Pinto, C. Jorge, F. Purcarea, T. Wutthachusin, R. Strasser, I. Kostavassili, M. Szulik, D. Danford, J. Vignalou, D. Popovic, M. Ruiz Ortiz, B. Popescu, O. Guseva, J. Rios Blanco, S. Purkayastha, D. Zaliaduonyte-Peksiene, J. Lopez Sendon, A. Magalhaes, G. Plehn, A. Tanrikulu, D. Mesa, G. Di Bella, D. Muraru, M. Salvetti, A. Arandjelovic, and M. Costantino

Subjects
medicine.medical_specialty, business.industry, Alternative medicine, Physical therapy, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2012
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27. Radiological findings in acuteHaemophilus influenzaepulmonary infection

Author

R Ishii, S Matsushita, Fumito Okada, Hiromu Mori, S Tanoue, Asami Ono, T Maeda, and Y Ando

Subjects
Adult, Lung Diseases, Male, Pathology, medicine.medical_specialty, Haemophilus Infections, Adolescent, Heart Diseases, Pleural effusion, medicine.disease_cause, Malignancy, Gastroenterology, Haemophilus influenzae, Young Adult, Risk Factors, Internal medicine, Streptococcus pneumoniae, medicine, Humans, Radiology, Nuclear Medicine and imaging, Lung, Lymph node, Aged, Retrospective Studies, Asthma, Aged, 80 and over, Full Paper, business.industry, Smoking, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, medicine.anatomical_structure, Pulmonary Emphysema, Female, Tomography, X-Ray Computed, business
Abstract

The aim of this study was to assess pulmonary thin-section CT findings in patients with acute Haemophilus influenzae pulmonary infection.Thin-section CT scans obtained between January 2004 and March 2009 from 434 patients with acute H. influenzae pulmonary infection were retrospectively evaluated. Patients with concurrent infection diseases, including Streptococcus pneumoniae (n=76), Staphylococcus aureus (n=58) or multiple pathogens (n=89) were excluded from this study. Thus, our study group comprised 211 patients (106 men, 105 women; age range, 16-91 years, mean, 63.9 years). Underlying diseases included cardiac disease (n=35), pulmonary emphysema (n=23), post-operative status for malignancy (n=20) and bronchial asthma (n=15). Frequencies of CT patterns and disease distribution of parenchymal abnormalities, lymph node enlargement and pleural effusion were assessed by thin-section CT.The CT findings in patients with H. influenzae pulmonary infection consisted mainly of ground-glass opacity (n=185), bronchial wall thickening (n=181), centrilobular nodules (n=137) and consolidation (n=112). These abnormalities were predominantly seen in the peripheral lung parenchyma (n=108). Pleural effusion was found in 22 patients. Two patients had mediastinal lymph node enlargement.These findings in elderly patients with smoking habits or cardiac disease may be characteristic CT findings of H. influenzae pulmonary infection.

Published
2012
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28. Atopic dermatitis and allergic rhinitis (PP-054)

Author

N. Inagaki, T. Matsubara, H. Kim, Y. Khotimchenko, M. Yamashita, Z. Pourpak, H. Mizuguchi, K. Watanabe, K. Bae, M. Nakaya, A. Majd, D. Lee, J. Jin, L. Taala, R. Geha, H. Kwon, M. Masuoka, S. M. Lind, S. So, T. Ito, A. Luster, A. Scheynius, T. Shahrestani, J. Yoon, C. Johansson, H. Luo, Y. Kitamura, N. Watanabe, K. Hashimoto, M. Mesdaghi, N. S. Koshkarova, M. Vodjgani, K. Terasawa, Y. Kohno, T. Nakayama, M. Iwai, L. Lundeberge, M. Chen, H. Lim, Y. Kim, S. Suzuki, E. Salehi, H. Shiraishi, S. Matsushita, R. Afshar, S. Makino, M. Kitajima, M. Kanno, T. I. Salikova, H. Sutoh, T. Namiki, T. Higashi, B. Chiang, W. Kuroda, M. Irago, N. Sergeeva, R. He, I. Wang, A. A. Denisov, H. Inoue, N. Takeda, O. Kwon, H. Janakiraman, N. Shimojo, K. Izuhara, R. Bogdanovich, M. Oyoshi, Y. Chen, N. Shimojyo, S. Ohta, R. Takagi, Y. Hirasaki, C. Iwamura, K. Sugiura, F. Lee, M. Furue, J. Hadjati, Y. Li, M. C. I. Karlsson, V. V. Klimov, K. Shinoda, Y. Tomita, H. Fukui, K. Su, T. V. Koshovkina, A. Sarrafnejad, and Y. Muro

Subjects
medicine.medical_specialty, Allergy, business.industry, Immunology, medicine, Immunology and Allergy, General Medicine, Atopic dermatitis, medicine.disease, business, Dermatology
Published
2010
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29. Immunity to bacterial infection (excluding mycobacteria) (PP-060)

Author

T. Majumdar, Y. Shen, T. Ikebe, H. Galkowska, A. Razavi, S. Lu, Z. Lacinova, M. Kalani, I. T. Lin, E. P. Koroleva, D. Hu, T. Tsubata, M. van Meurs, G. Fernández, F. Shokri, M. S. Blake, O. G. Ribeiro, K. Onozaki, Y. Fu, A. Retamal, C. Yeh, I. Gjertsson, Y. Gan, L. Henningsson, S. Goyert, T. Nomura, I. Choi, S. Daim, A. Straskova, L. C. Peters, A. Borrego, S. V. Melnikova, M. Shekarabi, T. E. Michaelsen, B. Rearte, A. Ribeiro, A. V. Kruglov, M. L. Nilles, A. Rivera, E. B. Andrade, T. Takii, P. Fernández, T. Tsuji, D. L. W. Chong, A. Nakane, M. Farhadi, E. N. De Gaspari, Y. Emoto, J. Silver, J. S. Gunn, H. Nanbara, M. Tebianian, Y. Yoshida, J. Stulik, O. Secka, O. M. Rybakova, R. Pastelin-Palacios, M. Antonio, H. Kobayashi, T. Nagasawa, A. A. Oñate, J. Kelly, S. A. Nedospasov, M. Pevsner-Fischer, V. P. Zav'yalov, J. Bruzzo, M. A. Moreno Eutimio, S. Metkar, M. Mitsuyama, S. A. Popova, M. Ramírez-Aguilar, A. V. Tumanov, C. López-Macías, D. Gazivoda, I. Kawamura, R. J. Ingram, H. Osório, J. J. Wu, P. R. Castro, A. Galvan, A. Maglioco, S. Koyasu, S. Kiany, A. V. Tretiyakova, P. Spidlova, S. Blazickova, K. Narita, P. Ferreira, N. Williams, T. Eneljung, K. A. Hodgson, S. Tanaka, M. Ato, C. Q. Ma, T. A. Dragani, T. Kokubo, N. Levchik, R. Riquelme, A. Sikora, N. Tsao, M. Tsuiji, R. Botek, M. Tanaka, A. Rezaei Mokarram, R. Adegbola, M. Shoji, L. Cerrvantes-Barragan, M. Yousefi, M. Popovic, C. Gil-Cruz, L. V. Mikhina, Y. Hara, T. Matsumura, H. Watanabe, G. Lackovic, M. Kroca, L. Eisenbach, L. N. Nesterenko, S. Ebrahimi, T. Ferreira, L. Bonifaz, M. Emoto, A. Magryś, Y. C. Chang, M. Jarrah Zadeh, J. Marek, C. H. Hung, Y. Iwakura, S. Howie, A. Yoshimura, S. Yona, R. Yashiro, J. Paluch-Oleś, N. Yokobori, M. Taghizadeh, K. M. Lam, M. Yano, S. J. Park, J. Wang, H. Valpotic, T. Noguchi, L. Wei, Y. Lim, W. Olszewski, C. Bin, S. Wongratanacheewin, Z. Piao, K. Tsuchiya, A. Osanai, D. S. Bradley, N. I. Shapiro, O. A. Karpova, A. Mitani, R. Shahrami, S. Sriskandan, C. Jung, T. Dzopalic, K. H. Seo, S. C. Clarke, S. Tomic, L. Cerveny, D. Vucevic, N. Imai, T. Canhamero, N. Starobinas, H. Lin, R. Ruggiero, A. Zavaran Hoseini, Y. Matsumura, W. H. K. Cabrera, S. N. Faust, K. Kobayashi, K. V. Shumilov, S. Dramsi, E. Silverpil, J. A. Boch, T. Shimizu, T. Faal, E. Abbasi, I. R. Cohen, S. Matsushita, A. Cordeiro-da-Silva, Y. y. Guo, J. Morris, M. Salari, F. Golsaz-Shirazi, H. Jung, Y. S. Lin, N. Vijtjuk, Y. H. Chou, D. Park, F. Rahimi Bashar, J. M. Jefferies, Y. J. Kim, T. N. Cunha, H. Qu, T. Kikuchi, K. Hiromatsu, M. Markova, K. Nakayama, D. V. Kuprash, Y. Koyama, K. Haruyama, B. K. L. Langerud, Y. Xu, N. Wara-aswapati, L. Arriaga-Pizano, S. I. Han, M. Talebi-Taher, M. Kozioł-Montewka, M. Wójtowicz, W. Brigitte, M. Akkoyunlu, C. Tien, D. Saez, C. I. Pérez-Shibayama, G. Zhang, D. V. Balunets, D. Spoljaric, A. Memarnejadian, P. A. MacAry, P. Trieu-Cuot, B. Govan, T. Suga, G. Kamoshida, K. Asano, E. Hamada, N. V. Kobets, E. García-Zepeda, I. Valpotic, A. Puangpetch, S. Vasilijic, N. Cohen, Y. Bando, C. F. Kuo, R. Anderson, N. Ketheesan, H. Chen, S. Mazumder, G. Gu, C. Poyart, M. Christodoulides, L. Oliveira, R. Margailt, A. Moravej, A. Dragicevic, F. Bozic, K. S. Kim, P. Jirholt, S. Kharb, M. Correira-Neves, K. Janatova, A. Bojang, R. Itoh, J. Djokic, A. Podbielska, E. Stelmach, F. Vorraro, A. Linden, S. Charan, F. Ebrahimi Taj, K. Yano, Y. Y. Wu, J. R. Jensen, S. D. Dewamitta, J. N. Kim, C. Lindholm, A. Tabatabaei, A. Kovšca-Janjatović, D. E. Lowther, M. Isturiz, N. Katsenelson, W. C. Aird, T. Yamamoto, M. Aino, T. Nagai, N. Sohrabi, J. Khoshnoodi, A. A. Denisov, M. Kishimoto, V. A. Magalhães, C. Guzmán, S. Kanswal, Y. S. Korobovtseva, N. Gerasimova, C. Alpuche-Aranda, J. Chia, S. Itoh, I. K. G. Andreasson, J. Alves, H. Hara, C. Chiu, S. Chiba, Y. Abiko, M. Colic, M. Barati, D. Caugant, M. Naito, V. Melichacova, Y. Wang, P. Cejkova, S. Jung, M. Santic, R. Wongratanacheewin, M. Rasouli, M. De Franco, F. Tahmasebi, D. M. Altmann, H. Sashinami, G. Makenzie, K. M. Salmakov, S. Yeo, S. Noorbakhsh, M. Cerna, A. S. Tocheva, F. Ike, A. Isibasi, O. Voronova, Y. Izumi, N. D. Lambert, O. M. Ibañez, P. Madureira, O. D. Sklyarov, K. Dubravko, S. Sakai, I. Becker, H. y. Gu, L. Balboa, and A. S. Apt

Subjects
Immunity, Immunology, Immunology and Allergy, General Medicine, Biology, Microbiology
Published
2010
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30. Mandibular reconstruction with bone transport in a patient with osteogenesis imperfecta

Author

Izumi Yoshioka, M. Fujita, Jinichi Fukuda, Amit Khanal, Kazuhiro Tominaga, Yukoh Muraki, and S. Matsushita

Subjects
Male, Connective Tissue Disorder, Bone Regeneration, Dentinogenesis imperfecta, medicine.medical_treatment, Nonunion, Osteogenesis, Distraction, Ilizarov Technique, Young Adult, Dentinogenesis Imperfecta, medicine, Humans, business.industry, Mandible, Anatomy, Osteogenesis Imperfecta, Plastic Surgery Procedures, medicine.disease, Osteochondrodysplasia, Osteotomy, Mandibular Neoplasms, stomatognathic diseases, Treatment Outcome, Otorhinolaryngology, Osteogenesis imperfecta, Fibroma, Ossifying, Distraction osteogenesis, Surgery, Oral Surgery, Segmental resection, business
Abstract

Osteogenesis imperfecta (OI) was originally considered a connective tissue disorder, primarily involving type 1 collagen. It is characterized by numerous skeletal and extraskeletal defects, including bone fragility, multiple fractures, blue sclerae, hearing deficits, skin and ligament laxity, and dentinogenesis imperfecta (DI). The authors describe a 24-year-old Japanese man with OI and DI who had an ossifying fibroma of the mandible. Segmental resection was performed, and the mandible was reconstructed by distraction osteogenesis with the transport segment technique. This is the first report to describe a patient with OI undergoing mandibular reconstruction with bone transport, to the authors' knowledge.

Published
2008
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31. Impurity doping in silicon nanowires synthesized by laser ablation

Author

S. Matsushita, Noriyuki Uchida, Kouichi Murakami, Naoki Fukata, Jun Chen, Takashi Sekiguchi, and Naoya Okada

Subjects
Laser ablation, Materials science, Silicon, Scattering, Phonon, Doping, Analytical chemistry, Nanowire, chemistry.chemical_element, General Chemistry, Molecular physics, Pulsed laser deposition, Condensed Matter::Materials Science, symbols.namesake, chemistry, Condensed Matter::Superconductivity, symbols, Condensed Matter::Strongly Correlated Electrons, General Materials Science, Raman spectroscopy
Abstract

Boron (B) or phosphorus (P) doped silicon nanowires (SiNWs) were synthesized by laser ablation. Local vibrational modes of B were observed in B-doped SiNWs by micro-Raman scattering measurements at room temperature. Fano broadening due to a coupling between the discrete optical phonon and a continuum of interband hole excitations was also observed in the Si optical phonon peak for B-doped SiNWs. An electron spin resonance signal due to conduction electrons was observed only for P-doped SiNWs. These results prove that B and P atoms were doped in substitutional sites of the crystalline Si core of SiNWs during laser ablation and electrically activated in the sites.

Published
2008
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32. Hydrogen passivation of P donors and defects in P-doped silicon nanowires synthesized by laser ablation

Author

Naoki Fukata, Takashi Sekiguchi, Kouichi Murakami, Noriyuki Uchida, Jun Chen, Takao Tsurui, and S. Matsushita

Subjects
Laser ablation, Materials science, Silicon, Hydrogen, Passivation, Doping, technology, industry, and agriculture, Nanowire, chemistry.chemical_element, Condensed Matter Physics, Photochemistry, Electronic, Optical and Magnetic Materials, law.invention, Pulsed laser deposition, chemistry, law, Electrical and Electronic Engineering, Electron paramagnetic resonance
Abstract

Hydrogen passivation of phosphorus (P) donors and defects in P-doped silicon nanowires (SiNWs) were investigated by electron spin resonance (ESR) at 4.2 K. P doping was performed during the synthesis of SiNWs by laser ablation. Phosphorus doping into substitutional sites of crystalline Si in SiNWs was demonstrated by detection of an ESR signal with a g-value of 1.998, which corresponds to conduction electrons in crystalline Si. ESR signals related to defects in surface oxide layer and at interface between surface oxide and crystalline Si core were observed. These P donors and the defects were partially passivated by hydrogen and oxygen atoms as seen in bulk Si.

Published
2007
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33. Phonon Confinement and Impurity Doping in Silicon Nanowires Synthesized by Laser Ablation

Author

Kouichi Murakami, Jun Chen, Takao Tsurui, Takashi Sekiguchi, Naoki Fukata, S. Matsushita, T. Oshima, and Naoya Okada

Subjects
Thermal oxidation, Materials science, Laser ablation, Condensed matter physics, Phonon, Doping, Analytical chemistry, chemistry.chemical_element, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Condensed Matter::Materials Science, symbols.namesake, chemistry, Condensed Matter::Superconductivity, Molecular vibration, symbols, Condensed Matter::Strongly Correlated Electrons, General Materials Science, Boron, Silicon nanowires, Raman scattering
Abstract

The effect of phonon confinement and impurity doping in silicon nanowires (SiNWs) synthesized by laser ablation were investigated. The diameter of SiNWs was controlled by the synthesis parameters during laser ablation and the subsequent thermal oxidation. Thermal oxidation increases the thickness of the SiNWs’ surface oxide layer, resulting in a decrease in their crystalline Si core diameter. This effect causes a downshift and asymmetric broadening of the Si optical phonon peak due to phonon confinement. Boron doping was also performed during the growth of SiNWs. Local vibrational modes of boron (B) in silicon nanowires (SiNWs) synthesized by laser ablation were observed at about 618 and 640 cm–1 by Raman scattering measurements. Fano broadening due to coupling between discrete optical phonons and the continuum of interband hole excitations was also observed in the Si optical phonon peak. These results prove that B atoms were doped in the SiNWs.

Published
2007
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34. The 2014 ALMA Long Baseline Campaign: An Overview

Author

ALMA Partnership, E. B. Fomalont, C. Vlahakis, S. Corder, A. Remijan, D. Barkats, R. Lucas, T. R. Hunter, C. L. Brogan, Y. Asaki, S. Matsushita, W. R. F. Dent, R. E. Hills, N. Phillips, A. M. S. Richards, P. Cox, R. Amestica, D. Broguiere, W. Cotton, A. S. Hales, R. Hiriart, A. Hirota, J. A. Hodge, C. M. V. Impellizzeri, J. Kern, R. Kneissl, E. Liuzzo, N. Marcelino, R. Marson, A. Mignano, K. Nakanishi, B. Nikolic, J. E. Perez, L. M. Pérez, I. Toledo, R. Aladro, B. Butler, J. Cortes, P. Cortes, V. Dhawan, J. Di Francesco, D. Espada, F. Galarza, D. Garcia-Appadoo, L. Guzman-Ramirez, E. M. Humphreys, T. Jung, S. Kameno, R. A. Laing, S. Leon, J. Mangum, G. Marconi, H. Nagai, L.-A. Nyman, M. Radiszcz, J. A. Rodón, T. Sawada, S. Takahashi, R. P. J. Tilanus, T. van Kempen, B. Vila Vilaro, L. C. Watson, T. Wiklind, F. Gueth, K. Tatematsu, A. Wootten, A. Castro-Carrizo, E. Chapillon, G. Dumas, I. de Gregorio-Monsalvo, H. Francke, J. Gallardo, J. Garcia, S. Gonzalez, J. E. Hibbard, T. Hill, T. Kaminski, A. Karim, M. Krips, Y. Kurono, C. Lopez, S. Martin, L. Maud, F. Morales, V. Pietu, K. Plarre, G. Schieven, L. Testi, L. Videla, E. Villard, N. Whyborn, M. A. Zwaan, F. Alves, P. Andreani, A. Avison, M. Barta, F. Bedosti, G. J. Bendo, F. Bertoldi, M. Bethermin, A. Biggs, J. Boissier, J. Brand, S. Burkutean, V. Casasola, J. Conway, L. Cortese, B. Dabrowski, T. A. Davis, M. Diaz Trigo, F. Fontani, R. Franco-Hernandez, G. Fuller, R. Galvan Madrid, A. Giannetti, A. Ginsburg, S. F. Graves, E. Hatziminaoglou, M. Hogerheijde, P. Jachym, I. Jimenez Serra, M. Karlicky, P. Klaasen, M. Kraus, D. Kunneriath, C. Lagos, S. Longmore, S. Leurini, M. Maercker, B. Magnelli, I. Marti Vidal, M. Massardi, A. Maury, S. Muehle, S. Muller, T. Muxlow, E. O’Gorman, R. Paladino, D. Petry, J. Pineda, S. Randall, J. S. Richer, A. Rossetti, A. Rushton, K. Rygl, A. Sanchez Monge, R. Schaaf, P. Schilke, T. Stanke, M. Schmalzl, F. Stoehr, S. Urban, E. van Kampen, W. Vlemmings, K. Wang, W. Wild, Y. Yang, S. Iguchi, T. Hasegawa, M. Saito, J. Inatani, N. Mizuno, S. Asayama, G. Kosugi, K.-I. Morita, K. Chiba, S. Kawashima, S. K. Okumura, N. Ohashi, R. Ogasawara, S. Sakamoto, T. Noguchi, Y.-D. Huang, S.-Y. Liu, F. Kemper, P. M. Koch, M.-T. Chen, Y. Chikada, M. Hiramatsu, D. Iono, M. Shimojo, S. Komugi, J. Kim, A.-R. Lyo, E. Muller, C. Herrera, R. E. Miura, J. Ueda, J. Chibueze, Y.-N. Su, A. Trejo-Cruz, K.-S. Wang, H. Kiuchi, N. Ukita, M. Sugimoto, R. Kawabe, M. Hayashi, S. Miyama, P. T. P. Ho, N. Kaifu, M. Ishiguro, A. J. Beasley, S. Bhatnagar, J. A. Braatz III, D. G. Brisbin, N. Brunetti, C. Carilli, J. H. Crossley, L. D’Addario, J. L. Donovan Meyer, D. T. Emerson, A. S. Evans, P. Fisher, K. Golap, D. M. Griffith, A. E. Hale, D. Halstead, E. J. Hardy, M. C. Hatz, M. Holdaway, R. Indebetouw, P. R. Jewell, A. A. Kepley, D.-C. Kim, M. D. Lacy, A. K. Leroy, H. S. Liszt, C. J. Lonsdale, B. Matthews, M. McKinnon, B. S. Mason, G. Moellenbrock, A. Moullet, S. T. Myers, J. Ott, A. B. Peck, J. Pisano, S. J. E. Radford, W. T. Randolph, U. Rao Venkata, M. G. Rawlings, R. Rosen, S. L. Schnee, K. S. Scott, N. K. Sharp, K. Sheth, R. S. Simon, T. Tsutsumi, S. J. Wood, National Radio Astronomy Observatory (NRAO), Joint ALMA Observatory (JAO), European Southern Observatory (ESO)-National Radio Astronomy Observatory (NRAO), Institute for Ethnomedicine, University of Wyoming (UW), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Chimie des métaux de transition et catalyse (CMTC), Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I, Istituto di Radioastronomia [Bologna] (IRA), Istituto Nazionale di Astrofisica (INAF), Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ESO, European Southern Observatory (ESO), Department of Organic and Polymeric Materials, Tokyo Institute of Technology [Tokyo] (TITECH), Biogeochemistry Research Centre, School of Chemistry, Onsala Space Observatory, Chalmers University of Technology [Göteborg], Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), AMOR 2015, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Departamento de Analisis Matematico, Universidad de Málaga [Málaga] = University of Málaga [Málaga], Unité de recherche Zoologie Forestière (URZF), Institut National de la Recherche Agronomique (INRA), IFP Energies nouvelles (IFPEN), Fastopt GmbH, D-20357 Hamburg, Germany, Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS), Departament de Ecologia, Universitat d'Alacant, Centro de Estudios Ambientales del Mediterraneo, INAF - Osservatorio Astrofisico di Arcetri (OAA), Faculty of Medicine, Universidad de Chile = University of Chile [Santiago] (UCHILE), Université Pierre et Marie Curie - Paris 6 (UPMC), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Laboratoire de génie électrique de Paris (LGEP), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Supérieure d'Electricité - SUPELEC (FRANCE)-Centre National de la Recherche Scientifique (CNRS), Astronomical Institute of the Czech Academy of Sciences (ASU / CAS), Czech Academy of Sciences [Prague] (CAS), Max-Planck-Institut für Radioastronomie (MPIFR), Northern Illinois University (NORTHERN ILLINOIS UNIVERSITY), Northern Illinois University, Centre for Astrophysics Research [Hatfield], University of Hertfordshire [Hatfield] (UH), Jodrell Bank Centre for Astrophysics (JBCA), University of Manchester [Manchester], foreign laboratories (FL), CERN [Genève], Departements of Medicine and Microbiology, University of Alabama [Tuscaloosa] (UA), Swinburne University of Technology (Hawthorn campus), San Pedro de Atacama Celestial Explorations (SPACE), San Pedro de Atacama Celestial Explorations, General Electric Medical Systems [Buc] (GE Healthcare), General Electric Medical Systems, Laboratoire de Radiopathologie (LRP), Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Milano [Milano] (UNIMI), Altération génétique des cancers, chimioprévention et réponse thérapeutique, Physikalisches Institut [Köln], Universität zu Köln, Ministère de la santé, National Astronomical Observatory of Japan (NAOJ), National Institute for Materials Science (NIMS), Espaces acoustiques et cognitifs (EAC), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Département de Mathématiques et Applications - ENS Paris (DMA), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Department of Chemistry and Biochemistry [Bern], University of Bern, Academia Sinica, Department of Marine Organic Biogeochemistry, Royal Netherlands Institute for Sea Research (NIOZ), Faculty of Geosciences, Utrecht University, Faculty of Geosciences, Brain Mind Institute (BMI - EPFL), Ecole Polytechnique Fédérale de Lausanne (EPFL), Departamento de Ingenieria Eléctrica (DIE), Universidad de Concepción [Chile], Laboratório de Bioinformática, Embrapa Recursos Genéticos e Biotecnologia, Graduate School of Engineering [The Univ of Tokyo] (UTokyo), The University of Tokyo (UTokyo), Kyushu University [Fukuoka], Mitsubishi Research Institute, Inc., Department of Computer Science and Automation [Bangalore] (CSA), Indian Institute of Science [Bangalore] (IISc Bangalore), National Radio Astronomy Observatory [Socorro] (NRAO), Occupational Physiology Laboratory (Vandœuvre-Les -Nancy, France), Computational Science and Engineering Department [Daresbury] (STFC), Science & Technologie Facilities Council, University College of London [London] (UCL), Centre for Atmospheric Chemistry [Wollongong] (CAC), University of Wollongong [Australia], Safety science group, Delft University of Technology (TU Delft), Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble (CIC-IT Grenoble (CIT803)), CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Northern Research Station, Forest Research [Great Britain], Department of Helsinki Institute for Information Technology Communications and Networking, Aalto University, University of Washington [Seattle], Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Astronomy, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Università degli Studi di Milano = University of Milan (UNIMI), Universität zu Köln = University of Cologne, Universidad de Concepción - University of Concepcion [Chile], Kyushu University, Istituto di Radioastronomia (IRA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Universidad de Málaga [Málaga], Unité de recherche Zoologie Forestière (UZF), Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Université Paris Descartes - Paris 5 (UPD5), University of Chile [Santiago], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-SUPELEC-Centre National de la Recherche Scientifique (CNRS), Astronomical Institute of the Czech Academy of Sciences, Czech Academy of Sciences [Prague] (ASCR), Jodrell Bank Centre for Astrophysics, School of Physics, Università degli studi di Milano [Milano], National Institute of Materials Science, Equipe Espaces acoustiques et cognitifs, Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS), Department of Chemistry and Biochemistry, Graduate School of Engineering [Tokyo], The University of Tokyo, Center for Atmospheric Chemistry [Wollongong] (CAC), University of Wollongong, CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), Forest Research, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École normale supérieure - Paris (ENS Paris), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Grenoble, Joint ALMA Office (JAO), ALMA, Institut Jacques Monod (IJM), Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Mathématiques et de leurs Interactions-Université Paris Descartes - Paris 5 (UPD5), ALMA Observatory, Laboratoire d'analyse et d'architecture des systèmes [Toulouse] (LAAS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique [Toulouse] (INP), Center for Brain Simulation, Ecole Polytechnique Fédérale de Lausanne, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM), National Radio Astronomy Observatory ( NRAO ), Joint ALMA Office ( JAO ), University of Wyoming ( UW ), Max-Planck-Institut für Astronomie ( MPIA ), Chimie des métaux de transition et catalyse ( CMTC ), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Istituto di Radioastronomia ( IRA ), Istituto Nazionale di Astrofisica ( INAF ), Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), European Southern Observatory ( ESO ), Tokyo Institute of Technology [Tokyo] ( TITECH ), Institut de RadioAstronomie Millimétrique ( IRAM ), Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Astrophysique de Bordeaux [Pessac] ( LAB ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Unité de recherche Zoologie Forestière ( UZF ), Institut National de la Recherche Agronomique ( INRA ), IFP Energies nouvelles ( IFPEN ), Science et Technologie du Lait et de l'Oeuf ( STLO ), Institut National de la Recherche Agronomique ( INRA ) -AGROCAMPUS OUEST, Mathématiques Appliquées à Paris 5 ( MAP5 - UMR 8145 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National des Sciences Mathématiques et de leurs Interactions-Centre National de la Recherche Scientifique ( CNRS ), INAF - Osservatorio Astrofisico di Arcetri ( OAA ), Université Pierre et Marie Curie - Paris 6 ( UPMC ), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition ( ICAN ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP], Laboratoire de génie électrique de Paris ( LGEP ), Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -SUPELEC-Centre National de la Recherche Scientifique ( CNRS ), Czech Academy of Sciences [Prague] ( ASCR ), Max-Planck-Institut für Radioastronomie ( MPIFR ), Northern Illinois University ( NORTHERN ILLINOIS UNIVERSITY ), Canadian Space Agency, foreign laboratories ( FL ), University of Alabama [Tuscaloosa] ( UA ), San Pedro de Atacama Celestial Explorations ( SPACE ), General Electric Medical Systems [Buc] ( GE Healthcare ), Laboratoire de Radiopathologie ( LRP ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Max Planck Institute for Biochemistry, Max-Planck-Institut, Department of Virology, Global COE Program, Nagasaki University-Institute of Tropical Medicine, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Département de Mathématiques et Applications - ENS Paris ( DMA ), École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'analyse et d'architecture des systèmes [Toulouse] ( LAAS ), Centre National de la Recherche Scientifique ( CNRS ) -Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse ( INSA Toulouse ), Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Institut National Polytechnique [Toulouse] ( INP ), Royal Netherlands Institute for Sea Research ( NIOZ ), Departamento de Ingenieria Eléctrica ( DIE ), AUTRES, Department of Computer Science and Automation [Bangalore] ( CSA ), Indian Institute of Science [Bangalore] ( IISc Bangalore ), National Radio Astronomy Observatory [Socorro] ( NRAO ), Computational Science and Engineering Department [Daresbury] ( STFC ), University College of London [London] ( UCL ), Center for Atmospheric Chemistry [Wollongong] ( CAC ), Delft University of Technology ( TU Delft ), Service Hématologie, Hôpital Morvan [Brest]-Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble ( CIC-IT Grenoble (CIT803) ), and Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Universitaire de Grenoble

Subjects
[SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], techniques: high angular resolution, Astronomy and Astrophysics, submillimeter: general, telescopes, Submillimeter Array, [ SDU.ASTR.CO ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Space and Planetary Science, techniques: interferometric, Environmental science, Millimeter, Baseline (configuration management), instrumentation: interferometers, QB, Remote sensing
Abstract

著者人数: 248名, Accepted: 2015-04-10, 資料番号: SA1150145000

Published
2015
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35. Disinhibition of somatosensory evoked potential recovery in alcoholics

Author

Toshihiro Masaki, Kazuo Motoyoshi, Hidetaka Mochizuki, S. Matsushita, Keiko Kamakura, and S. Higuchi

Subjects
Male, medicine.medical_specialty, Sensory system, Electroencephalography, Audiology, Somatosensory system, Evoked Potentials, Somatosensory, medicine, Humans, Analysis of Variance, medicine.diagnostic_test, business.industry, Case-control study, Somatosensory Cortex, Middle Aged, Median nerve, Alcoholism, Neurology, Somatosensory evoked potential, Disinhibition, Case-Control Studies, Neurology (clinical), Analysis of variance, medicine.symptom, Cognition Disorders, business, Neuroscience
Abstract

The pathogenesis of cognitive impairment in alcoholics remains unclear. Previous studies suggested that diffuse white matter atrophy is associated with cognitive impairment in alcoholics. To elucidate this issue, the present study evaluated alcoholics with cognitive impairment using the somatosensory evoked potential (SEP) recovery method, which is suitable for detecting subtle dysfunction at the cortical level. Subjects comprised 12 alcoholics with mild cognitive impairment [Mild group: Mini Mental State Examination Score (MMSE), > or =24; mean, 27.9 +/- 1.6], 12 alcoholics with moderate to severe cognitive impairment (Moderate group: MMSE score, < 24; mean, 21.0 +/- 2.5) and 12 normal subjects (Control group). SEP was recorded from the hand sensory area contralateral to the median nerve stimulated at the wrist. Single-pulse or paired-pulse stimuli at various interstimulus intervals (10-300 ms) were administered. Recovery functions of N9 (a peripheral nerve component), N20, N20-P25 and P25-N33 (cortical components) were studied. N20 recovery curves of both alcoholic groups were less suppressive than those of Controls, and P25-N33 recovery curves of the Moderate group were more excitatory than those of the Mild or Control groups. A disinhibited recovery pattern of N20 indicates subcortical dysfunction, and a disinhibited pattern of P25-N33 would be induced by cortical dysfunction. Therefore, subcortical dysfunction indicated by an abnormal N20 recovery pattern may contribute to the early cognitive impairment of alcoholics, whilst the cortical dysfunction indicated by an abnormal P25-N33 recovery pattern may contribute to the later cognitive impairment of alcoholics.

Published
2006
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36. Cognitive impairment and diffuse white matter atrophy in alcoholics

Author

Yoshikazu Ugawa, Keiko Kamakura, S. Matsushita, Hiroyuki Arai, Hidetaka Mochizuki, Susumu Higuchi, Toshihiro Masaki, and Kazuo Motoyoshi

Subjects
Male, medicine.medical_specialty, Pathology, Neural Conduction, Neuropsychological Tests, Audiology, Brain mapping, Central nervous system disease, White matter, Atrophy, Alzheimer Disease, Evoked Potentials, Somatosensory, Physiology (medical), medicine, Humans, Aged, Retrospective Studies, Cerebral Cortex, Analysis of Variance, Brain Mapping, medicine.diagnostic_test, Cognitive disorder, Magnetic resonance imaging, Cognition, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Sensory Systems, Alcoholism, Diffusion Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology, Linear Models, Female, Neurology (clinical), Alzheimer's disease, Cognition Disorders, Psychology
Abstract

Diffuse brain white matter atrophy is often seen in chronic alcoholics, but its relation with cognitive impairment remains to be solved. In order to address this issue, in alcoholics with cognitive impairment at different levels, we studied relations of the central sensory conduction time (CSCT) or brain magnetic resonance imaging (MRI) findings with the cognitive function.Subjects were 35 alcoholics with mild cognitive impairment (mini-mental state examination score, MMSE,/=24; mean+/-SD, 27.7+/-1.9), 12 with moderate to severe cognitive impairment (MMSE24; 20.3+/-2.7), 15 with Alzheimer's disease (AD) (MMSE, 18.9+/-4.3) (disease control) and 20 healthy volunteers (MMSE, 28.5+/-1.6) (normal control). Median nerve SEPs were recorded in the all subjects, and the latencies and amplitudes of their N9, N11, P13/14, N20 and P25 components were measured. The ventriculocranial ratio (VCR) and the width of cortical sulci were measured on MRIs. These physiological parameters and MRI findings were compared between the 4 groups of the subject, and correlations between those all features were also analyzed.CSCT and VCR were significantly greater in alcoholics with moderate to severe cognitive impairment than those in the other 3 groups. Pearson's product-moment correlation analyses of the alcoholics disclosed that both the CSCT and VCR had significant negative correlations with the MMSE score. Moreover, the CSCT and VCR were positively correlated.Both physiological and morphological estimates of the white matter function (CSCT and VCR) had a significant correlation with the cognitive dysfunction.The diffuse white matter atrophy may be one of the factors causing cognitive impairment in chronic alcoholics.

Published
2005
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37. Characterization of lactate dehydrogenase-elevating virus ORF6 protein expressed by recombinant baculoviruses

Author

Hiromi Takahashi-Omoe, Katsuhiko Omoe, T. Inada, and S. Matsushita

Subjects
Antigenicity, Genes, Viral, Recombinant Fusion Proteins, viruses, Lactate dehydrogenase-elevating virus, Immunology, Spodoptera, Microbiology, Virus, Cell Line, Mice, Open Reading Frames, Viral Envelope Proteins, Polyhedrin, Animals, Immunology and Allergy, Antigens, Viral, Arterivirus Infections, Base Sequence, General Veterinary, biology, Nuclear Polyhedrosis Virus, General Medicine, biology.organism_classification, Fusion protein, Virology, Molecular biology, Nucleopolyhedroviruses, Protein M, Autographa californica, Infectious Diseases, DNA, Viral, Lactate dehydrogenase elevating virus
Abstract

Lactate dehydrogenase-elevating virus (LDV) has a strict species-specificity and can replicate only in a subset of mouse primary macrophages in vitro. Because it is difficult to grow and purify sufficient quantities of LDV virions from the primary macrophages, it has been difficult to further characterize LDV envelope proteins. A few expression systems have been reported for structural analysis of the nonglycosylated envelope protein M/VP-2, however, very few studies of the antigenicity of M/VP-2 have been reported. We cloned and expressed the ORF6 gene, which encodes the M/VP-2, as a fusion protein with a polyhistidine metal-binding tag (6×His-tag) in Autographa californica nuclear polyhedrosis virus (baculovirus) under the control of the polyhedrin promoter. In Western blotting analysis, the expressed protein was similar in size to the native M/VP-2 plus 6×His-tag. The usefulness of the baculovirus-expressed LDV ORF6 protein for analysis of the immunogenicity of LDV M/VP-2 was discussed.

Published
2004
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38. Analysis of protein expression by mammalian cell lines stably expressing lactate dehydrogenase-elevating virus ORF 5 and ORF 6 proteins

Author

Katsuhiko Omoe, Masahiro Sakaguchi, Y. Kameoka, T. Inada, S. Matsushita, and Hiromi Takahashi-Omoe

Subjects
Lactate dehydrogenase-elevating virus (LDV), Stable expression, Gene Expression Regulation, Viral, viruses, Blotting, Western, Lactate dehydrogenase-elevating virus, Immunology, Transfection, Expression stable, Microbiology, Article, M/VP-2, Open Reading Frames, symbols.namesake, VP-3, Viral Envelope Proteins, Virus d'élévation de la lactate déshydrogénase (LDV), Viral entry, Chlorocebus aethiops, Animals, Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase, Immunology and Allergy, Gene, Membrane Glycoproteins, General Veterinary, biology, General Medicine, ORF6, Golgi apparatus, ORF5, biology.organism_classification, Molecular biology, Blot, Open reading frame, Infectious Diseases, Microscopy, Fluorescence, Cell culture, Cytoplasm, COS Cells, symbols, Lactate dehydrogenase elevating virus
Abstract

Lactate dehydrogenase-elevating virus (LDV) has a strict species-specificity. Because only a subset of mouse primary macrophages have been identified that can support LDV replication in vitro, the precise molecular mechanism of viral entry and replication remains unclear. To analyze the LDV envelope proteins, which probably mediate viral attachment to the host cell, we developed a mammalian system for stable co-expression of LDV open reading frame (ORF) 5- and ORF 6-encoded proteins (ORF 5 and ORF 6 proteins), which correspond to envelope VP-3 and M/VP-2, respectively, and compared these expressed proteins to the native ones. Western blotting analysis combined with N-glycanase digestion revealed that ORF 5 and ORF 6 proteins were similar in size to native VP-3 and M/VP-2, and that ORF 5 protein was N-glycosylated, like the native VP-3. Immunofluorescence microscopy revealed that both ORF 5 and ORF 6 proteins were distributed throughout the cytoplasm and were colocalized in most cells. Moreover, ORF 5 protein was localized both in the perinuclear region and the Golgi complex and transported to the cell surface. This mammalian expression system in which the exogenously expressed proteins closely resemble the native proteins will provide the experimental basis for further studies of the interactions between LDV envelope proteins and host cells.

Published
2004
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39. Study of Identification for the Inertia Constant in a Small Power System for LFC

Author

Katsuhiro Ichiyanagi, Katsunori Mizuno, Hidenori Aoki, S. Matsushita, Y. Mizutani, Kazuto Yukita, and Yasuyuki Goto

Subjects
Power station, media_common.quotation_subject, MathematicsofComputing_NUMERICALANALYSIS, Power factor, Inertia, Electric power system, Power system simulation, Control theory, ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION, Economics, Power-flow study, Constant (mathematics), Tie line, ComputingMethodologies_COMPUTERGRAPHICS, media_common
Abstract

This paper has tried the identification for the inertia constant in a small power system, for the betterment of the LFC control characteristic. The power demand estimation method was used for the method of identifying an inertia constant power system. Until now, the method that used as an output set-point control by the power demand estimation is improved to the identification method. The power demand estimation method is using the frequency variation, the tie line power flow deviation, the output deviation of power plant, the inertia coefficient and damping coefficient of power system. In this paper, the actual electric power demand, the output of power plant, etc. was observed and the inertia coefficient is calculated using this estimation method. Then, the inertia constant and the damping constant are not observed. In this paper, the inertia coefficient of the system of 2000kW small-scale system was calculated.

Published
2003
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40. Effect of crack-healing and proof-testing procedures on fatigue strength and reliability of Si3N4/SiC composites

Author

Kotoji Ando, S. Matsushita, Min-Cheol Chu, and S. Sato

Subjects
Cyclic stress, Materials science, Composite number, Fatigue limit, Reliability (semiconductor), Flexural strength, visual_art, mental disorders, Vickers hardness test, Materials Chemistry, Ceramics and Composites, visual_art.visual_art_medium, Ceramic, Composite material, Compact tension specimen
Abstract

A Si3N4/SiC composite was hot-pressed. Using this material, fatigue tests on crack-healed and proof-tested specimens were conducted at 1000–1400 °C. A surface elliptical-crack of about 110 μm in diameter was introduced on the specimens using a Vickers hardness indenter. The crack-healing was performed at 1300 °C for 1 h in air, mainly. The fatigue limit of the crack-healed and proof-tested specimen (C.P specimen) decreased slightly with increasing test temperature. However, the crack-healed specimen is not sensitive to low-cycle fatigue up to 1400 °C, and the fatigue limit is almost equal to the minimum bending strength at each temperature. To investigate the reason, the crack-healing behavior under cyclic stress was carried out systematically at 1200 °C in air. A 110 μm surface crack could be healed perfectly at 1200 °C in air under cyclic stress with a frequency of 0.001–5 Hz. From this, it can be concluded that [crack-healing+proof test] and crack-healing during service are useful techniques for maintaining structural integrity of these ceramic components.

Published
2003
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42. Interaction among human leucocyte antigen-peptide-T cell receptor complexes in cow's milk allergy: the significance of human leucocyte antigen and T cell receptor-complementarity determining region 3 loops

Author

Naomi Kondo, S. Matsushita, Hideo Kaneko, R. Inoue, Z. Kato, K. Suzuki, M. Watanabe, and H. Sakaguchi

Subjects
T cell, Immunology, Antigen presentation, T-cell receptor, T lymphocyte, Human leukocyte antigen, Complementarity determining region, Biology, medicine.anatomical_structure, Antigen, medicine, Immunology and Allergy, Antigen-presenting cell
Abstract

Summary Background Allergic individuals respond to only a few specific antigens, therefore allergic diseases are characterized by antigen specificity. Clarification of the mechanism of antigen specificity will lead to progress in the therapy of allergic diseases. Objectives The purpose of this study is to determine the specific association among T cell epitopes, antigen-presenting molecules and T cell receptor (TCR), and to determine the TCR usage in the pathogenesis of allergies using antigen-specific T cell clones (TCCs). The results can clarify the mechanism of the antigen specificity of allergic diseases, and provide new therapeutic possibilities using analogue peptides. Methods Short-term T cell clones specific to β-lactoglobulin (BLG) were established from peripheral blood mononuclear cells (PBMCs) collected from five patients allergic to cow's milk. We then identified the T cell epitopes and antigen-presenting molecules, and examined TCR usage. We also determined the sequence of the TCR-complementarity-determining region 3 (CDR3). Results Six TCCs established from the five patients recognized three different peptides, and BLGp97–117 was recognized by four of the six TCCs. BLGp101–112 (KYLLFCMENSAE) was the core sequence in the fragment. Sequence analysis of TCR by the RT-PCR method revealed a marked heterogeneity in TCR usage, and similar amino acid sequences were recognized in the CDR3 region. Four of the six TCCs recognized BLG in association with human leucocyte antigen (HLA)-DRB1*0405 as antigen-presenting molecules. Conclusion We proposed the motif of the interaction between the HLA-DRB1*0405 allele and antigen peptide, and suggested that HLA-DRB1*0405 is an immunoregulatory gene product for T cell responses to BLG.

Published
2002
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43. Molecular and cellular analyses of HLA class II-associated susceptibility to autoimmune diseases in the Japanese population

Author

Y. Nishimura, H. Ito, S. Fujii, H. Tabata, Y. Tokano, Y.-Z. Chen, I. Matsuda, H. Mitsuya, J. Kira, H. Hashimoto, S. Senju, and S. Matsushita

Subjects
Rheumatology
Abstract

It is well known that individuals who are positive for particular HLA class II alleles show a high risk of developing autoimmune diseases. HLA class II molecules expressed on antigen-presenting cells present antigenic peptides to CD4(+) T cells. Their extensive polymorphism affects the structures of peptides bound to HLA class II molecules to create individual differences in immune responses to antigenic peptides. In order to gain a better understanding of mechanisms of the association between HLA class II alleles and susceptibility to autoimmune diseases, it is important to identify self-peptides presented by disease-susceptible HLA class II molecules and triggering disease-causative T cells. Many of the autoimmune diseases are observed in all ethnic groups, whereas the incidence of diseases, clinical manifestations and disease-susceptible HLA class II alleles are different among various ethnic groups for some autoimmune diseases. These phenomena suggest that differences in autoimmune self-peptide(s) in the context of disease-susceptible HLA class II molecules may cause these differences. Therefore, comparisons among disease-susceptible HLA class II alleles, autoantigenic peptides, and clinical manifestations of autoimmune diseases in different ethnic groups would be helpful in elucidating the pathogenesis of the diseases. In this review, we describe our recent findings on (1) the uniqueness of both clinical manifestations and the HLA-linked genetic background of Asian-type (opticospinal form) multiple sclerosis, (2) the characteristics of glutamic acid decarboxylase 65 (GAD65) or β2-glycoprotein I (β2-GPI) autoreactive T cells in Japanese patients with insulin-dependent diabetes mellitus (IDDM) or anti-β2-GPI antibody-associated autoimmunity, respectively, and (3) the generation of an efficient delivery system of peptides to the HLA class II-restricted antigen presentation path-way by utilizing a class II-associated invariant chain peptide (CLIP)-substituted invariant chain, which may be applicable to an evaluation of the "molecular mimicry hypothesis" for the activation of autoreactive T cells.

Published
2014

44. A headset-based minimized wearable computer

Author

S. Matsushita

Subjects
Computer Networks and Communications, business.industry, Computer science, Headset, Wearable computer, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Context (language use), law.invention, Bluetooth, Microcontroller, Artificial Intelligence, law, Embedded system, Wireless, Transceiver, business, Motion sensors, Computer hardware
Abstract

A headset with a sensory system and a short-range wireless radio transceiver can become a highly available, context-aware peripheral device. The author describes a headset that uses a combination of low-power motion sensors and microcontrollers to translate a user's behavior into corresponding symbolic codes.

Published
2001
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45. Factors influencing joint-preserving operations in the treatment of the late stages of osteoarthritis of the hip

Author

S. Ohsawa, Y. Inamori, S. Matsushita, H. Norimatsu, and R. Ueno

Subjects
musculoskeletal diseases, Orthopedics and Sports Medicine, Surgery
Abstract

Between November 1983 and December 1992, 136 hips (119 patients) with coxarthritis were operated on using joint-preserving techniques based on the rationale of Pauwels’ osteotomy. The criterion for selection was a patient in whom the height of the joint space in the weight-bearing area of the hip was less than 1 mm. The mean age at operation was 48 years and the mean follow-up 109 months (60 to 171). Hips were categorised using Bombelli’s classification of osteoarthritis, into atrophic and non-atrophic types. The endpoint was defined as that at which the height of the joint space became less than 1 mm again. The Kaplan-Meier curve showed that the rate of survival of the non-atrophic group was significantly better than that of the atrophic group. Cox’s proportional hazard model indicated that the factors influencing the results of joint-preserving operations included Bombelli’s classification, postoperative incongruence of the joint and the height of the joint space.

Published
2000
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46. Species and Serovar-Distribution, and Drug-Resistance of Shigella Strains Isolated from Imported and Domestic Cases during 1995-1999 in Tokyo

Author

S, Matsushita, M, Arimatsu, M, Takahashi, K, Yokoyama, N, Konishi, Y, Yanagawa, S, Yamada, and S, Morozumi

Subjects
Serotype, medicine, Shigella, Microbial Sensitivity Tests, General Medicine, Drug resistance, Serotyping, Biology, medicine.disease_cause, Anti-Bacterial Agents, Microbiology
Abstract

A total of 290 Shigella strains consisting of 180 imported strains and 110 domestic strains isolated during 1995-1999 in Tokyo were examined regarding their species and serovar-distribution and their drug-resistance. In both groups, S. sonnei (70.0% in the imported strains, 80.9% in the domestic strains) was found to be the most prevalent species, followed by S. flexneri (20.0% in the imported strains, 19.1% in the domestic strains). S. dysenteriae and S. boydii were only isolated in the imported cases. Among the S. flexneri serovar, 1b, 2a, 6, 2b, and 3a were predominant in the imported strains, whereas 1b and 2a were predominant in the domestic strains. Provisional new serovar Shigella strains were isolated from 11 imported cases and 2 domestic cases. The drug-resistance test using 9 drugs (CP, TC, SM, KM, ABPC, ST, NA, FOM, and NFLX) showed that 92.2% of the imported strains and 94.5% of the domestic strains were resistant to some of the drugs tested. Drug-resistance patterns of the resistant strains varied in 25 types. Among those, a triple drug-resistance type with TC.SM.ST was found as the most frequent pattern in both groups. None of the strains were resistant to NFLX.

Published
2000
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47. A New Framework for Fuzzy Modeling Using Genetic Algorithm

Author

Takeshi Furuhashi, H. Tsutsui, and S. Matsushita

Subjects
Human-Computer Interaction, Adaptive neuro fuzzy inference system, Fuzzy classification, Neuro-fuzzy, Artificial Intelligence, business.industry, Computer science, Genetic algorithm, Fuzzy set operations, Computer Vision and Pattern Recognition, Artificial intelligence, business, Fuzzy logic
Abstract

This paper presents a new framework for fuzzy modeling using genetic algorithm. A model of actual object in the real world should satisfy various criteria, such as precision, generality, noise immunity, etc. It has been difficult for the fuzzy modeling to allocate proper weights on these criteria. The framework introduced in this paper consists of a model generation block and a model-testing block. The model generation block generates candidates of fuzzy model under criteria with higher importance, and the model-testing block tests the candidates under notso-important criteria. This division of criteria can put emphasis on the criteria in the generation block and less on those in the testing block. Simulations are done to show the effectiveness of the proposed framework.

Published
1999
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48. Identification of Peptide Superagonists for a Self-K-ras-Reactive CD4+ T Cell Clone Using Combinatorial Peptide Libraries and Mass Spectrometry

Author

Y, Tanaka, H, Ohyama, M, Ogawa, Y, Nishimura, and S, Matsushita

Subjects
CD4-Positive T-Lymphocytes, Molecular Sequence Data, Immunology, Lymphocyte Activation, Mass Spectrometry, Peptide Fragments, Clone Cells, Molecular Weight, Amino Acid Substitution, Peptide Library, ras Proteins, Humans, Immunology and Allergy, Amino Acid Sequence, Peptides
Abstract

The proliferative responses of a human CD4+ T cell clone 29.15.2, reactive with a self-K-ras-derived peptide (3EYKLVVVGAGGVGKSALT20), were tested using a set of X9 combinatorial peptide libraries containing the flanking residues (EYKLVXXXXXXXXXSALT, where X indicates random amino acids). Certain peptide libraries, such as EYKLVXXXXXXcmd UNLMcmd /UNLXXSALT and EYKLVXXXXXXXcmd UNLHcmd /UNLXSALT, stimulated a marked proliferation of 29.15.2. However, no combinations of substitutions tested, such as EYKLVXXXXXXcmd UNLMHcmd /UNLXSALT, exhibited additive effects. We subsequently synthesized peptides with degenerate sequences (a mixture of 480 species), where each position is composed of the wild-type (wt) residue or of amino acids that induced the proliferation of 29.15.2, in positional scanning. Interestingly, one fraction of degenerate peptides, separated by reverse-phase HPLC, stimulated much higher proliferation than did the wt; in addition, the retention time of this fraction was distinct from that of the wt. Mass spectrometry analysis of this fraction and flanking fractions identified five peptide species that exhibit strong signals in a manner that parallels the antigenic activity. Finally, 17 candidate peptide sequences were deduced from mass spectrometry and hydrophobicity scoring results, of which two peptides (EYKLVVVGAGGcmd UNLMLcmd /UNLKSALT and EYKLVVVGAGGcmd UNLMIcmd /UNLKSALT) did induce 52- and 61-fold stronger proliferation, respectively, compared with the wt. These findings indicate that: 1) synthetic peptides that carry "the best" residue substitution at each position of combinatorial peptide libraries do not always exhibit superagonism, and 2) such a drawback can be overcome with the use of mass spectrometry. This approach provides new perspectives for the accurate and efficient identification of peptide superagonists.

Published
1999
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49. Effects of home-based exercise with expiratory muscle training on the prevention of falls and aspiration pneumonia in community-dwelling older adults

Author

Daisuke Matsumoto, Katsuhiko Takatori, M. Nishida, and S. Matsushita

Subjects
medicine.medical_specialty, Rehabilitation, business.industry, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Aspiration pneumonia, University hospital, medicine.disease, Physical medicine and rehabilitation, Patient satisfaction, Telephone interview, Telerehabilitation, medicine, Physical therapy, Home based exercise, business, Expiratory muscle
Abstract

accessed from anywhere with minimal disruptions to their daily routine. A telerehabilitation project was initiated at our university hospital since 2012 using iPads onVirtual Personal Networks (VPN), called the e-MADO system (electronic Multidirectional Access andDelightful Opportunity-offering System). At the moment, the take-up rate for this option for family/patient consultation regarding their follow-up rehabilitation and monitoring is low with only 4 participants. The reason for this is unclear. Purpose: The aim of this study was to conduct a patient satisfaction survey to obtain feedback on the e-MADO system from these participants in order to understand the shortcomings and problemswith the e-MADO system so that improvements may be proposed and undertaken. Methods:A telephone interview was conducted to obtain feedback from the 4 participants in 5 main areas

Published
2015
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50. Middle-term results of anatomic medullary locking total hip arthroplasty

Author

S. Ohsawa, K. Fukuda, R. Ueno, H. Norimatsu, S. Mori, and S. Matsushita

Subjects
Male, medicine.medical_specialty, Time Factors, Medullary cavity, Chirurgie orthopedique, Arthroplasty, Replacement, Hip, medicine.medical_treatment, Dentistry, Prosthesis Design, Prosthesis, Statistics, Nonparametric, Poor quality, Bone quality, medicine, Humans, Orthopedics and Sports Medicine, Aged, Retrospective Studies, Observer Variation, business.industry, Bone Cements, Femur Head, General Medicine, Middle Aged, Stress shielding, equipment and supplies, Surgery, Radiography, Orthopedic surgery, Female, Hip Joint, Hip Prosthesis, business, Follow-Up Studies, Total hip arthroplasty
Abstract

We report the results of cementless, anatomic, medullary locking hip prosthesis application in our first consecutive series. We used the so-called Asian size of prosthesis with proportionally smaller stem sizes in both diameter and length. Forty-seven stems and sockets were analyzed with a mean follow-up of 69 months. The mean Merle d'Aubigné hip scores were 8 points preoperatively and 16 points at the final follow-up. Radiologically, the stems showed excellent stability without loosening. Stress shielding around the stems did occur in most cases but did not progress. Preoperative bone quality influenced the extent of stress shielding evaluated at the final follow-up: higher stress shielding was noted in poorer quality bones at the time of operation. There were problems with the sockets. The shallow socket and impingement at the protruded rim seemed to cause a high incidence of dislocation (13%). Massive polyethylene wear occurred in 5 sockets. These sockets were 48 and 46 mm in diameter with 26 mm heads. In conclusion, the stems of the anatomic medullary locking hip prostheses used in Japan showed satisfactory stability even in poor quality bones, but there were problems with the polyethylene liners. Our solution was to use larger sockets with 22 mm heads.

Published
1998
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