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33 results on '"Rzemieniec, Joanna"'

3. Multigenerational Consequences of Prenatal Exposure to Benzophenone-3 Demonstrate Sex- and Region-Dependent Neurotoxic and Pro-Apoptotic Effects in Mouse Brain.

Author

Przepiórska-Drońska, Karolina, Łach, Andrzej, Pietrzak-Wawrzyńska, Bernadeta Angelika, Rzemieniec, Joanna, Kajta, Małgorzata, Wawrzczak-Bargieła, Agnieszka, Bilecki, Wiktor, Noworyta, Karolina, and Wnuk, Agnieszka

Subjects
PRENATAL exposure, CEREBRAL cortex, ENDOCRINE disruptors, HYGIENE products, MATERNAL exposure
Abstract

Benzophenone-3 (BP-3), commonly used as a UV filter in personal care products and as a stabilizer, is an alleged endocrine disruptor with potential neurodevelopmental impacts. Despite its abundance in the environment, the studies on its effect on brain development are scarce, especially in terms of multigenerational impact. In this work, for the first time, we examined neurotoxic and pro-apoptotic effects of BP-3 on mouse brain regions (cerebral cortex and hippocampus) in both the first (F1) and second (F2) generations after maternal exposure to environmentally relevant BP-3 levels. We found disregulated markers of cell damage (LDH, H2O2, caspase-3 and -8) and observed increased expression of pro-apoptotic Fas/FAS or Fasl/FASL. BP-3 exposure disrupted the BAX/BCL2 pathway, showing stronger effects in the F1 than in the F2 generation, with a dominance of extrinsic pathway (FAS, FASL, caspase-8) over intrinsic one (BAX, BCL2), suggesting that BP-3-induced apoptosis primarily operates via the extrinsic pathway and could impair brain homeostasis across generations. This study underscores the potential of BP-3 to increase multigenerational risks associated with disrupted neurodevelopment and highlights the importance of understanding its long-term neurotoxic effects. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke

Author

Valente, Alessia, Mariani, Jacopo, Seminara, Serena, Tettamanti, Mauro, Pignataro, Giuseppe, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Diamanti, Susanna, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rodriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Di Santo, Chiara, Cuomo, Ornella, Gullotta, Giorgia Serena, Butti, Erica, Bagetta, Giacinto, Martino, Gianvito, De Simoni, Maria-Grazia, Ferrarese, Carlo, Fumagalli, Stefano, and Beretta, Simone

Published
2023
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15. sj-pdf-1-jcb-10.1177_0271678X231159958 - Supplemental material for Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke

Author

Valente, Alessia, Mariani, Jacopo, Seminara, Serena, Tettamanti, Mauro, Pignataro, Giuseppe, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Diamanti, Susanna, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rodriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Di Santo, Chiara, Cuomo, Ornella, Gullotta, Giorgia Serena, Butti, Erica, Bagetta, Giacinto, Martino, Gianvito, De Simoni, Maria-Grazia, Ferrarese, Carlo, Fumagalli, Stefano, and Beretta, Simone

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231159958 for Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke by Alessia Valente, Jacopo Mariani, Serena Seminara, Mauro Tettamanti, Giuseppe Pignataro, Carlo Perego, Luigi Sironi, Felicita Pedata, Diana Amantea, Marco Bacigaluppi, Antonio Vinciguerra, Susanna Diamanti, Martina Viganò, Francesco Santangelo, Chiara Paola Zoia, Virginia Rodriguez-Menendez, Laura Castiglioni, Joanna Rzemieniec, Ilaria Dettori, Irene Bulli, Elisabetta Coppi, Chiara Di Santo, Ornella Cuomo, Giorgia Serena Gullotta, Erica Butti, Giacinto Bagetta, Gianvito Martino, Maria-Grazia De Simoni, Carlo Ferrarese, Stefano Fumagalli, Simone Beretta and for the TRICS study group in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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20. Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science networkMulticentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science network

Author

Tettamanti, Mauro, primary, Beretta, Simone, additional, Pignataro, Giuseppe, additional, Fumagalli, Stefano, additional, Perego, Carlo, additional, Sironi, Luigi, additional, Pedata, Felicita, additional, Amantea, Diana, additional, Bacigaluppi, Marco, additional, Vinciguerra, Antonio, additional, Valente, Alessia, additional, Diamanti, Susanna, additional, Mariani, Jacopo, additional, Viganò, Martina, additional, Santangelo, Francesco, additional, Zoia, Chiara Paola, additional, Rogriguez-Menendez, Virginia, additional, Castiglioni, Laura, additional, Rzemieniec, Joanna, additional, Dettori, Ilaria, additional, Bulli, Irene, additional, Coppi, Elisabetta, additional, Gullotta, Giorgia Serena, additional, Bagetta, Giacinto, additional, Martino, Gianvito, additional, Ferrarese, Carlo, additional, and De Simoni, Maria Grazia, additional

Published
2020
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21. Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science network

Author

Tettamanti, M, Beretta, S, Pignataro, G, Fumagalli, S, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Valente, A, Diamanti, S, Mariani, J, Viganò, M, Santangelo, F, Zoia, C, Rogriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Gullotta, G, Bagetta, G, Martino, G, Ferrarese, C, De Simoni, M, Tettamanti, Mauro, Beretta, Simone, Pignataro, Giuseppe, Fumagalli, Stefano, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Valente, Alessia, Diamanti, Susanna, Mariani, Jacopo, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rogriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Gullotta, Giorgia Serena, Bagetta, Giacinto, Martino, Gianvito, Ferrarese, Carlo, De Simoni, Maria Grazia, Tettamanti, M, Beretta, S, Pignataro, G, Fumagalli, S, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Valente, A, Diamanti, S, Mariani, J, Viganò, M, Santangelo, F, Zoia, C, Rogriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Gullotta, G, Bagetta, G, Martino, G, Ferrarese, C, De Simoni, M, Tettamanti, Mauro, Beretta, Simone, Pignataro, Giuseppe, Fumagalli, Stefano, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Valente, Alessia, Diamanti, Susanna, Mariani, Jacopo, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rogriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Gullotta, Giorgia Serena, Bagetta, Giacinto, Martino, Gianvito, Ferrarese, Carlo, and De Simoni, Maria Grazia

Abstract

Introduction Multicentre preclinical randomised controlled trials (pRCT) are emerging as a necessary step to confirm efficacy and improve translation into the clinic. The aim of this project is to perform two multicentre pRCTs (one in rats and one in mice) to investigate the efficacy of remote ischaemic conditioning (RIC) in an experimental model of severe ischaemic stroke. Methods and analysis Seven research laboratories within the Italian Stroke Organization (ISO) Basic Science network will participate in the study. Transient endovascular occlusion of the proximal right middle cerebral artery will be performed in two species (rats and mice) and in both sexes. Animals will be randomised to receive RIC by transient surgical occlusion of the right femoral artery, or sham surgery, after reperfusion. Blinded outcome assessment will be performed for dichotomised functional neuroscore (primary endpoint) and infarct volume (secondary endpoint) at 48 hours. A sample size of 80 animals per species will yield 82% power to detect a significant difference of 30% in the primary outcome in both pRCTs. Analyses will be performed in a blind status and according to an intention-to-treat paradigm. The results of this study will provide robust, translationally oriented, high-quality evidence on the efficacy of RIC in multiple species of rodents with large ischaemic stroke. Ethics and dissemination This is approved by the Animal Welfare Regulatory Body of the University of Milano Bicocca, under project license from the Italian Ministry of Health. Trial results will be subject to publication according to the definition of the outcome presented in this protocol.

Published
2020

33. Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science network

Author

Diana Amantea, Luigi Sironi, Carlo Perego, Virginia Rogriguez-Menendez, Ilaria Dettori, Stefano Fumagalli, Maria Grazia De Simoni, Elisabetta Coppi, Giacinto Bagetta, Simone Beretta, Irene Bulli, Giorgia Serena Gullotta, Mauro Tettamanti, Joanna Rzemieniec, Antonio Vinciguerra, Laura Castiglioni, Susanna Diamanti, Carlo Ferrarese, Alessia Valente, Giuseppe Pignataro, Jacopo Mariani, Chiara Zoia, Martina Viganò, Marco Bacigaluppi, Felicita Pedata, Gianvito Martino, Francesco Santangelo, Tettamanti, M, Beretta, S, Pignataro, G, Fumagalli, S, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Valente, A, Diamanti, S, Mariani, J, Viganò, M, Santangelo, F, Zoia, C, Rogriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Gullotta, G, Bagetta, G, Martino, G, Ferrarese, C, De Simoni, M, Tettamanti, Mauro, Beretta, Simone, Pignataro, Giuseppe, Fumagalli, Stefano, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Valente, Alessia, Diamanti, Susanna, Mariani, Jacopo, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rogriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Gullotta, Giorgia Serena, Bagetta, Giacinto, Martino, Gianvito, Ferrarese, Carlo, and De Simoni, Maria Grazia

Subjects
0301 basic medicine, medicine.medical_specialty, Italian Stroke Organization (ISO) Basic Science, Basic science, neuroscore, lcsh:Medicine, MCA occlusion, 03 medical and health sciences, 0302 clinical medicine, Occlusion, Ischaemic stroke, medicine, Clinical endpoint, Protocol, TRICS, cerebral ischemia, Remote ischemic conditioning, rat and mouse, Stroke, Protocol (science), business.industry, lcsh:R, Sham surgery, General Medicine, medicine.disease, 030104 developmental biology, Infarct volume, Physical therapy, Remote ischaemic conditioning (RIC), Settore BIO/14 - Farmacologia, Settore MED/26 - Neurologia, business, sperimental stroke, 030217 neurology & neurosurgery
Abstract

Introduction Multicentre preclinical randomised controlled trials (pRCT) are emerging as a necessary step to confirm efficacy and improve translation into the clinic. The aim of this project is to perform two multicentre pRCTs (one in rats and one in mice) to investigate the efficacy of remote ischaemic conditioning (RIC) in an experimental model of severe ischaemic stroke. Methods and analysis Seven research laboratories within the Italian Stroke Organization (ISO) Basic Science network will participate in the study. Transient endovascular occlusion of the proximal right middle cerebral artery will be performed in two species (rats and mice) and in both sexes. Animals will be randomised to receive RIC by transient surgical occlusion of the right femoral artery, or sham surgery, after reperfusion. Blinded outcome assessment will be performed for dichotomised functional neuroscore (primary endpoint) and infarct volume (secondary endpoint) at 48 hours. A sample size of 80 animals per species will yield 82% power to detect a significant difference of 30% in the primary outcome in both pRCTs. Analyses will be performed in a blind status and according to an intention-to-treat paradigm. The results of this study will provide robust, translationally oriented, high-quality evidence on the efficacy of RIC in multiple species of rodents with large ischaemic stroke. Ethics and dissemination This is approved by the Animal Welfare Regulatory Body of the University of Milano Bicocca, under project license from the Italian Ministry of Health. Trial results will be subject to publication according to the definition of the outcome presented in this protocol. Trial registration number PCTE0000177.

Published
2020

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