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We developed a new hybrid consisting of Ag nanoprisms, poly(N-isopropylacrylamide) (PNIPAm), and fluorophores via layer-by-layer assembly. The fluorescence intensity below the lower critical solution temperature (LCST) of PNIPAm was 6.4 times stronger than that above the LCST, meaning that the hybrids can function as nanosized highly thermoresponsive fluorescent sensors.

We experienced a 75-year-old male patient with a refractory and severely painful skin ulcer on the right back. He had suffered from ischemic heart disease and undergone percutaneous coronary intervention 5 months prior to the consultation with us. The characteristic clinical appearance, location of the lesion and his past medical history led us to the diagnosis of radiation-induced skin ulcer. Magnetic resonance imaging, computed tomography as well as bone scintigraphy showed fractures of the right back rib adjacent to the ulcer, which was thought to be attributable to bone damage due to X-ray radiation and/or persistent secondary inflammation of the chronic ulcer. In the published work, there are no other reports of bone fractures associated with radiation dermatitis after coronary interventional radiology.

平成20年5月から12月にかけて，九州大学病院皮膚科と関連病院皮膚科に通院中の，そう痒性皮膚疾患を有する患者107例(平均年齢は52.1±19.0歳，男女比=45 : 62)を対象として，少なくとも1 週間のベシル酸べポスタチン投与後に，そう痒の改善と日中の眠気，夜間の睡眠，服用に適した錠剤の色と形状，満足度などについてアンケート調査を行った。日中のそう痒の改善は全体で88.6％，夜間のそう痒の改善は89.5％で，疾患別にみると蕁麻疹群(日中 : 94.3％，夜間 : 97.1％)は湿疹・皮膚炎群(日中 : 87.2％，夜間 : 89.4％)に比べて有意に改善していた(P

Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor. We describe a case of superficial desmoplastic fibroblastoma presenting as a protruding nodule. A 41-year-old woman presented with a painless, firm, elevated nodule with ulceration on her left thigh. Histological examination from total excision showed a well-circumscribed tumor in the dermis, which comprised of spindle, oval and stellate cells arranged in a haphazard fashion, accompanied by abundant collagenous stroma and inconspicuous vasculature. Immunohistochemically, the tumor cells were positive for vimentin, and focally positive for alpha-smooth muscle actin and muscle-specific actin, but negative for CD34, S-100 protein, desmin and beta-catenin. We diagnosed this case as desmoplastic fibroblastoma arising in the dermis and superficial subcutaneous tissue.

57歳，男性。左側腹部から始まり躯幹四肢に拡大するそう痒を伴う小水疱，紅斑を認めた。病理組織所見では表皮の海綿状態，基底層の液状変性や真皮内の単核球，好酸球浸潤を認め多形滲出性紅斑様の像であった。また蛍光抗体直接法では陰性であった。ステロイド内服を開始したところ皮疹は軽快した。患者は約2年前より健康食品としてウコンを内服していた。後日施行したウコンのパッチテストでも陽性を示し，ウコンによる多形滲出性紅斑様薬疹と診断した。