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5 results on '"Ryusuke Shimada"'

1. Next-Generation Sequencing for Non-Ampullary Duodenal Carcinoma Suggesting the Existence of an Adenoma-Carcinoma Sequence

Author

Tsubasa Yoshida, Yohei Kojima, Ryusuke Shimada, Hidesato Tanabe, Koichi Tabei, Osamu Yanagida, Takashi Nikaido, Kouki Ohtsuka, Hiroaki Ohnishi, Nobutsugu Abe, Tadakazu Hisamatsu, and Shinichi Takahashi

Subjects
familial adenomatous polyposis, duodenal cancer, adenoma-carcinoma sequence, next-generation sequencing, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Duodenal tumors with a sporadic adenoma-carcinoma sequence are extremely rare. For such clinically suspected cases without a specific family history, performing a comprehensive gene search is important to understand the germline mutation background. We present a 68-year-old woman without a genetic or familial history of familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome, or Lynch syndrome who presented to Kosei Hospital, Japan, with exertional dyspnea induced by abdominal pain lasting 3 weeks. A duodenal tumor was suspected by contrast-enhanced computed tomography. Esophagogastroduodenoscopy showed a lesion accompanied by a white microprotuberance on the descending part of the duodenum opposite the papilla, with a giant ulcerative lesion at the center of the white lesion. Biopsy revealed a low-grade adenoma, high-grade adenoma, and adenocarcinoma. Immunohistochemical analysis of the adenoma and adenocarcinoma showed Ki-67, p53, cytokeratin 20, caudal-type homeobox 2, and carcinoembryonic antigen positivity and cytokeratin 7 negativity. The findings suggested the presence of an adenoma-adenocarcinoma sequence in duodenal carcinoma. However, in the mutational analysis using next-generation sequencing, c.4348C>T (p.Arg1450Ter) mutation in APC was detected in all normal mucosal, adenoma, and carcinoma tissues. This mutation is common in FAP patients. Even if the presence of an adenoma-adenocarcinoma sequence in duodenal carcinoma is suggested in cases without a familial FAP history, as in this case, genetic analysis may reveal FAP. Thus, performing a comprehensive genetic analysis of duodenal carcinoma patients with a possible adenoma-carcinoma sequence is necessary to explore their genetic background.

Published
2021
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2. A case of colorectal cancer associated with ulcerative colitis

Author

Tomoya Hiratsuka, Shin'ichi Takahashi, Masaaki Yokoyama, Takashi Yamaguchi, Ryusuke Shimada, Mayumi Ide, Osamu Yanagida, Osamu Ikezaki, Koichi Tabei, Eri Kondo, Hirotaka Ota, Takashi Nikaido, Mitsuhiro Nakao, and Hidesato Tanabe

Subjects
medicine.medical_specialty, business.industry, Colorectal cancer, Mechanical Engineering, Internal medicine, medicine, Energy Engineering and Power Technology, Management Science and Operations Research, medicine.disease, business, Ulcerative colitis, Gastroenterology
Published
2021

3. A case of advanced colonic cancer discovered by bacteremia caused by Streptococcus bovis

Author

Mayumi Ide, Azumi Kudo, Masaaki Yokoyama, Eri Kondo, Hirotaka Ota, Shin'ichi Takahashi, Koichi Tabei, Takashi Nikaido, Hidesato Tanabe, Osamu Yanagida, Takashi Yamaguchi, Ryusuke Shimada, Osamu Ikezaki, and Toru Harada

Subjects
Colonic cancer, biology, business.industry, Mechanical Engineering, Bacteremia, medicine, Energy Engineering and Power Technology, Management Science and Operations Research, Streptococcus bovis, biology.organism_classification, medicine.disease, business, Microbiology
Published
2020

4. Baffled membrane bioreactor (BMBR) for efficient nutrient removal from municipal wastewater

Author

Ryusuke Shimada, Yoshimasa Watanabe, Katsuki Kimura, Rie Nishisako, and Taro Miyoshi

Subjects
Environmental Engineering, Denitrification, Hydraulic retention time, Nitrogen, Chemistry, Ecological Modeling, Environmental engineering, Phosphorus, Membrane bioreactor, Waste Disposal, Fluid, Pollution, Bioreactors, Wastewater, Bioreactor, Sewage treatment, Nitrification, Aeration, Waste Management and Disposal, Water Pollutants, Chemical, Water Science and Technology, Civil and Structural Engineering
Abstract

Submerged membrane bioreactors (MBRs) are now widely used for various types of wastewater treatment. One drawback of submerged MBRs is the difficulty in removing nitrogen because intensive aeration is usually carried out in the tank and the MBRs must therefore be operated under aerobic conditions. In this study, the feasibility of treating municipal wastewater by a baffled membrane bioreactor (BMBR), particularly in terms of nitrogen removal, was examined. Simultaneous nitrification/denitrification in a single and small reaction tank was possible by inserting baffles into a normal submerged MBR as long as wastewater was fed in the appropriate way. To examine the applicability of the BMBR, pilot-scale experiments were carried out using real municipal wastewater. Although neither external carbon addition nor mixed liquor circulation was carried out in the operation of the BMBR, average removal rates of total organic carbon (TOC), total phosphorus (T-P) and total nitrogen (T-N) reached 85%, 97% and 77%, respectively, with the hydraulic retention time (HRT) of 4.7h. Permeability of the membrane could be maintained at a high level throughout the operation. It was found that denitrification was the limiting step in removal of nitrogen in the BMBR in this study. Various types of monitoring carried out in the BMBR also demonstrated the possibility of further improvements in its performance.

Published
2008

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