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Your search keyword '"Ryumina, Alina P."' showing total 9 results
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9 results on '"Ryumina, Alina P."'

2. Green Fluorescent Protein with Anionic Tryptophan-Based Chromophore and Long Fluorescence Lifetime

Author

Sarkisyan, Karen S., Goryashchenko, Alexander S., Lidsky, Peter V., Gorbachev, Dmitry A., Bozhanova, Nina G., Gorokhovatsky, Andrey Yu., Pereverzeva, Alina R., Ryumina, Alina P., Zherdeva, Victoria V., Savitsky, Alexander P., Solntsev, Kyril M., Bommarius, Andreas S., Sharonov, George V., Lindquist, Jake R., Drobizhev, Mikhail, Hughes, Thomas E., Rebane, Aleksander, Lukyanov, Konstantin A., and Mishin, Alexander S.

Published
2015
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7. KillerRed and miniSOG as genetically encoded photosensitizers for photodynamic therapy of cancer

Author

Shirmanova, Marina V., primary, Serebrovskaya, Ekaterina O., additional, Snopova, Ludmila B., additional, Kuznetsova, Maria M., additional, Ryumina, Alina P., additional, Turchin, Ilya V., additional, Sergeeva, Ekaterina A., additional, Ignatova, Nadezhda I., additional, Klementieva, Natalia V., additional, Lukyanov, Konstantin A., additional, Lukyanov, Sergey A., additional, and Zagaynova, Elena V., additional

Published
2013
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8. Phototoxic effects of lysosome-associated genetically encoded photosensitizer KillerRed.

Author

Serebrovskaya, Ekaterina O., Ryumina, Alina P., Boulina, Maria E., Shirmanov, Marina V., Zagaynov, Elena V., Bogdanova, Ekaterina A., Lukyanov, Sergey A., and Lukyanov, Konstantin A.

Subjects
*LYSOSOMES, *PHOTOSENSITIZERS, *LIGHTING, *LUMINOUS flux, *ORGANELLES
Abstract

KillerRed is a unique phototoxic red fluorescent protein that can be used to induce local oxidative stress by green-orange light illumination. Here we studied phototoxicity of KillerRed targeted to cytoplasmic surface of lysosomes via fusion with Rab7, a small GTPase that is known to be attached to membranes of late endosomes and lysosomes. It was found that lysosome-associated KillerRed ensures efficient light-induced cell death similar to previously reported mitochondria- and plasma membrane--localized KillerRed. Inhibitory analysis demonstrated that lysosomal cathepsins play an important role in the manifestation of KillerRed-Rab7 phototoxicity. Timelapse monitoring of cell morphology, membrane integrity, and nuclei shape allowed us to conclude that KillerRed-Rab7-mediated cell death occurs via necrosis at high light intensity or via apoptosis at lower light intensity. Potentially, KillerRed-Rab7 can be used as an optogenetic tool to direct target cell populations to either apoptosis or necrosis. [ABSTRACT FROM AUTHOR]

Published
2014
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