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1. A case of coagulation factor V inhibitor induced by immune checkpoint inhibitor therapy

Author

Yuki Haruta, Masanori Azuma, Toshikatsu Sado, Ryuichi Saito, Yoshimune Miyazaki, Akihiro Noda, Reina Kitagawa, Yasutaka Hori, Sayaka Fujimoto, Yoshinori Hasegawa, Tetsuya Ueda, and Ryosuke Yamamura

Subjects
haemophilia, factor V inhibitors, hem‐irAE, immune checkpoint inhibitors, Diseases of the respiratory system, RC705-779
Abstract

Abstract A 73‐year‐old woman with lung adenocarcinoma (cT4N3M1a: Stage IVA) was treated with atezolizumab as the eighth line of therapy. Four weeks after the fourth dose of atezolizumab, the prothrombin time (PT) and activated thromboplastin time (APTT) were prolonged. Coagulation factor V (FV) activity was decreased, and FV inhibitors were observed. There was no history of PT or APTT prolongation or bleeding before the use of atezolizumab. Atezolizumab‐induced coagulation FV inhibitor was diagnosed. After 2 weeks, the PT and APTT spontaneously normalized. FV activity improved and the FV inhibitors disappeared after 6 and 9 weeks, respectively.

Published
2024
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2. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Author

Qingbo S. Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Ho Lee, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashri Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Kazuto Kato, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, Junya Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, Nobuaki Mori, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Sakamoto Koji, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka-Aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima, Ayumi Yoshifuji, Kazuto Ito, Saeko Takahashi, Kota Ishioka, Morio Nakamura, Makoto Masuda, Aya Wakabayashi, Hiroki Watanabe, Suguru Ueda, Masanori Nishikawa, Yusuke Chihara, Mayumi Takeuchi, Keisuke Onoi, Jun Shinozuka, Atsushi Sueyoshi, Yoji Nagasaki, Masaki Okamoto, Sayoko Ishihara, Masatoshi Shimo, Yoshihisa Tokunaga, Yu Kusaka, Takehiko Ohba, Susumu Isogai, Aki Ogawa, Takuya Inoue, Satoru Fukuyama, Yoshihiro Eriguchi, Akiko Yonekawa, Keiko Kan-o, Koichiro Matsumoto, Kensuke Kanaoka, Shoichi Ihara, Kiyoshi Komuta, Yoshiaki Inoue, Shigeru Chiba, Kunihiro Yamagata, Yuji Hiramatsu, Hirayasu Kai, Koichiro Asano, Tsuyoshi Oguma, Yoko Ito, Satoru Hashimoto, Masaki Yamasaki, Yu Kasamatsu, Yuko Komase, Naoya Hida, Takahiro Tsuburai, Baku Oyama, Minoru Takada, Hidenori Kanda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Shinji Ogura, Shinji Abe, Yuta Kono, Yuki Togashi, Hiroyuki Takoi, Ryota Kikuchi, Shinichi Ogawa, Tomouki Ogata, Shoichiro Ishihara, Arihiko Kanehiro, Shinji Ozaki, Yasuko Fuchimoto, Sae Wada, Nobukazu Fujimoto, Kei Nishiyama, Mariko Terashima, Satoru Beppu, Kosuke Yoshida, Osamu Narumoto, Hideaki Nagai, Nobuharu Ooshima, Mitsuru Motegi, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Mayu Endo, Yoshiyuki Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Tomomi Takano, Kazuhiko Katayama, Masumi Ai, Atsushi Kumanogoh, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, and Yukinori Okada

Subjects
Science
Abstract

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Published
2022
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3. Immune Profile Analysis in Peripheral Blood and Tumor in Patients with Malignant Melanoma

Author

Ryuichi Saito, Yu Sawada, and Motonobu Nakamura

Subjects
melanoma, immune checkpoint, anti-PD1 antibody, nivolumab, immune cells, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Melanoma is a severe and life-threatening malignancy derived from melanocytes. The traditional treatment for melanoma could not sustain satisfactory outcomes long term; however, the recent immune checkpoint treatment has made a breakthrough in these problems. Nivolumab is a representative immune checkpoint treatment, and this PD-1-targeted therapy has evolutionally developed and improved the clinical outcome in a recent decade. On the other hand, the clinical application of immune checkpoint treatment presents clinicians with novel questions, especially how to obtain additional efficacy and overcome the disadvantage by using this treatment. To answer these problems, we first investigated the distribution of PD-L1 in various organs to clarify the organs most affected by anti-PD-1 antibody treatment. Among various organs, lung, placenta, spleen, heart, and thyroid highly expressed PD-L1, while skin, thalamus, hippocampus, ovary, stomach, testis, and prostate showed lower expressions of PD-L1. Furthermore, the immune profiles were also examined in tumors and peripheral blood in patients with melanoma. PD-1 was highly expressed in CD8 and CD4 cells, and B cells also highly expressed PD-1 compared with NK cells. However, there was no significant difference in Th1/Th2/Th17 cytokines and inhibitory cytokine IL-10. Although nevus showed a low expression of PD-L1 compared with healthy skin, PD-L1 expression was increased in growth-phase melanoma. Finally, we analyzed the peripheral blood profiles in patients treated with nivolumab. PD-1-bearing dendritic cells (DCs) were increased during nivolumab treatment and Lin-CD11c+HLA-DR+ cells were highly increased during nivolumab treatment. These findings indicate a clue to answering the problems during nivolumab treatment and suggest to us the importance of multiple aspect observation during immune checkpoint treatment.

Published
2021
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8. Author response for 'Clinical significance of pre‐diabetes, undiagnosed diabetes, and diagnosed diabetes on clinical outcomes in COVID‐19: Integrative analysis from the Japan COVID‐19 Task Force'

Author

null Takahiro Fukushima, null Shotaro Chubachi, null Ho Namkoong, null Takanori Asakura, null Hiromu Tanaka, null Ho Lee, null Shuhei Azekawa, null Yukinori Okada, null Ryuji Koike, null Akinori Kimura, null Seiya Imoto, null Satoru Miyano, null Seishi Ogawa, null Takanori Kanai, null Koichi Fukunaga, null Shiro Otake, null Kensuke Nakagawara, null Atsuho Morita, null Mayuko Watase, null Kaori Sakurai, null Takuya Kusumoto, null Katsunori Masaki, null Hiroki Kabata, null Hirofumi Kamata, null Makoto Ishii, null Naoki Hasegawa, null Kazuhisa Takahashi, null Norihiro Harada, null Toshio Naito, null Makoto Hiki, null Yasushi Matsushita, null Haruhi Takagi, null Ryousuke Aoki, null Ai Nakamura, null Sonoko Harada, null Hitoshi Sasano, null Shinnosuke Ikemura, null Satoshi Okamori, null Hideki Terai, null Junichi Sasaki, null Hiroshi Morisaki, null Yoshifumi Uwamino, null Kosaku Nanki, null Yohei Mikami, null Sho Uchida, null Shunsuke Uno, null Rino Ishihara, null Yuta Matsubara, null Tomoyasu Nishimura, null Takunori Ogawa, null Toshiro Sato, null Tetsuya Ueda, null Masanori Azuma, null Ryuichi Saito, null Toshikatsu Sado, null Yoshimune Miyazaki, null Ryuichi Sato, null Yuki Haruta, null Tadao Nagasaki, null Yoshinori Yasui, null Yoshinori Hasegawa, null Soichiro Ueda, null Ai Tada, null Masayoshi Miyawaki, null Masaomi Yamamoto, null Eriko Yoshida, null Reina Hayashi, null Tomoki Nagasaka, null Sawako Arai, null Yutaro Kaneko, null Kana Sasaki, null Takashi Ishiguro, null Taisuke Isono, null Shun Shibata, null Yuma Matsui, null Chiaki Hosoda, null Kenji Takano, null Takashi Nishida, null Yoichi Kobayashi, null Yotaro Takaku, null Noboru Takayanagi, null Etsuko Tagaya, null Masatoshi Kawana, null Ken Arimura, null Yasushi Nakamori, null Kazuhisa Yoshiya, null Fukuki Saito, null Tomoyuki Yoshihara, null Daiki Wada, null Hiromu Iwamura, null Syuji Kanayama, null Shuhei Maruyama, null Takanori Hasegawa, null Kunihiko Takahashi, null Tatsuhiko Anzai, null Satoshi Ito, null Akifumi Endo, null Yuji Uchimura, null Yasunari Miyazaki, null Takayuki Honda, null Tomoya Tateishi, null Shuji Tohda, null Naoya Ichimura, null Kazunari Sonobe, null Chihiro Tani Sassa, null Jun Nakajima, null Masumi Ai, null Takashi Yoshiyama, null Ken Ohta, null Hiroyuki Kokuto, null Hideo Ogata, null Yoshiaki Tanaka, null Kenichi Arakawa, null Masafumi Shimoda, null Takeshi Osawa, null Yasushi Nakano, null Yukiko Nakajima, null Ryusuke Anan, null Ryosuke Arai, null Yuko Kurihara, null Yuko Harada, null Kazumi Nishio, null Yoshikazu Mutoh, null Tomonori Sato, null Reoto Takei, null Satoshi Hagimoto, null Yoichiro Noguchi, null Yasuhiko Yamano, null Hajime Sasano, null Sho Ota, null Yusuke Suzuki, null Sohei Nakayama, null Keita Masuzawa, null Tomomi Takano, null Kazuhiko Katayama, null Koji Murakami, null Mitsuhiro Yamada, null Hisatoshi Sugiura, null Hirohito Sano, null Shuichiro Matsumoto, null Nozomu Kimura, null Yoshinao Ono, null Hiroaki Baba, null Rie Baba, null Daisuke Arai, null Takayuki Ogura, null Hidenori Takahashi, null Shigehiro Hagiwara, null Genta Nagao, null Shunichiro Konishi, null Ichiro Nakachi, null Hiroki Tateno, null Isano Hase, null Shuichi Yoshida, null Shoji Suzuki, null Miki Kawada, null Hirohisa Horinouchi, null Fumitake Saito, null Keiko Mitamura, null Masao Hagihara, null Junichi Ochi, null Tomoyuki Uchida, null Ryuya Edahiro, null Yuya Shirai, null Kyuto Sonehara, null Tatsuhiko Naito, null Kenichi Yamamoto, null Shinichi Namba, null Ken Suzuki, null Takayuki Shiroyama, null Yuichi Maeda, null Takuro Nii, null Yoshimi Noda, null Takayuki Niitsu, null Yuichi Adachi, null Takatoshi Enomoto, null Saori Amiya, null Reina Hara, null Toshihiro Kishikawa, null Shuhei Yamada, null Shuhei Kawabata, null Noriyuki Kijima, null Masatoshi Takagaki, null Noa Sasa, null Yuya Ueno, null Motoyuki Suzuki, null Norihiko Takemoto, null Hirotaka Eguchi, null Takahito Fukusumi, null Takao Imai, null Munehisa Fukushima, null Haruhiko Kishima, null Hidenori Inohara, null Kazunori Tomono, null Kazuto Kato, null Haruhiko Hirata, null Yoshito Takeda, null Atsushi Kumanogoh, null Naoki Miyazawa, null Yasuhiro Kimura, null Reiko Sado, null Hideyasu Sugimoto, null Akane Kamiya, null Naota Kuwahara, null Akiko Fujiwara, null Tomohiro Matsunaga, null Yoko Sato, null Takenori Okada, null Takashi Inoue, null Toshiyuki Hirano, null Keigo Kobayashi, null Hatsuyo Takaoka, null Koichi Nishi, null Masaru Nishitsuji, null Mayuko Tani, null Junya Suzuki, null Hiroki Nakatsumi, null Hidefumi Koh, null Tadashi Manabe, null Yohei Funatsu, null Fumimaro Ito, null Takahiro Fukui, null Keisuke Shinozuka, null Sumiko Kohashi, null Masatoshi Miyazaki, null Tomohisa Shoko, null Mitsuaki Kojima, null Tomohiro Adachi, null Motonao Ishikawa, null Kenichiro Takahashi, null Kazuyoshi Watanabe, null Yoshihiro Hirai, null Hidetoshi Kawashima, null Atsuya Narita, null Kazuki Niwa, null Yoshiyuki Sekikawa, null Hisako Sageshima, null Yoshihiko Nakamura, null Kota Hoshino, null Junichi Maruyama, null Hiroyasu Ishikura, null Tohru Takata, null Takashi Ogura, null Hideya Kitamura, null Eri Hagiwara, null Kota Murohashi, null Hiroko Okabayashi, null Takao Mochimaru, null Shigenari Nukaga, null Ryosuke Satomi Yoshitaka Oyamada, null Nobuaki Mori, null Tomoya Baba, null Yasutaka Fukui, null Mitsuru Odate, null Shuko Mashimo, null Yasushi Makino, null Kazuma Yagi, null Mizuha Hashiguchi, null Junko Kagyo, null Tetsuya Shiomi, null Kodai Kawamura, null Kazuya Ichikado, null Kenta Nishiyama, null Hiroyuki Muranaka, null Kazunori Nakamura, null Satoshi Fuke, null Hiroshi Saito, null Tomoya Tsuchida, null Shigeki Fujitani, null Mumon Takita, null Daiki Morikawa, null Toru Yoshida, null Takehiro Izumo, null Minoru Inomata, null Naoyuki Kuse, null Nobuyasu Awano, null Mari Tone, null Akihiro Ito, null Toshio Odani, null Masaru Amishima, null Takeshi Hattori, null Yasuo Shichinohe, null Takashi Kagaya, null Toshiyuki Kita, null Kazuhide Ohta, null Satoru Sakagami, null Kiyoshi Koshida, null Morio Nakamura, null Koutaro Yokote, null Taka‐Aki Nakada, null Ryuzo Abe, null Taku Oshima, null Tadanaga Shimada, null Kentaro Hayashi, null Tetsuo Shimizu, null Yutaka Kozu, null Hisato Hiranuma, null Yasuhiro Gon, null Namiki Izumi, null Kaoru Nagata, null Ken Ueda, null Reiko Taki, null Satoko Hanada, null Naozumi Hashimoto, null Keiko Wakahara, null Koji Sakamoto, null Norihito Omote, null Akira Ando, null Yu Kusaka, null Takehiko Ohba, null Susumu Isogai, null Aki Ogawa, null Takuya Inoue, null Nobuhiro Kodama, null Yasunari Kaneyama, null Shunsuke Maeda, null Takashige Kuraki, null Takemasa Matsumoto, null Masahiro Harada, null Takeshi Takahashi, null Hiroshi Ono, null Toshihiro Sakurai, null Takayuki Shibusawa, null Yusuke Kawamura, null Akiyoshi Nakayama, null Hirotaka Matsuo, null Yoshifumi Kimizuka, null Akihiko Kawana, null Tomoya Sano, null Chie Watanabe, null Ryohei Suematsu, null Makoto Masuda, null Aya Wakabayashi, null Hiroki Watanabe, null Suguru Ueda, null Masanori Nishikawa Ayumi Yoshifuji, null Kazuto Ito, null Saeko Takahashi, null Kota Ishioka, null Yusuke Chihara, null Mayumi Takeuchi, null Keisuke Onoi, null Jun Shinozuka, null Atsushi Sueyoshi, null Yoji Nagasaki, null Masaki Okamoto, null Sayoko Ishihara, null Masatoshi Shimo, null Yoshihisa Tokunaga, null Masafumi Watanabe, null Sumito Inoue, null Akira Igarashi, null Masamichi Sato, null Nobuyuki Hizawa, null Yoshiaki Inoue, null Shigeru Chiba, null Kunihiro Yamagata, null Yuji Hiramatsu, null Hirayasu Kai, null Satoru Fukuyama, null Yoshihiro Eriguchi, null Akiko Yonekawa, null Keiko Kano, null Koichiro Matsumoto, null Kensuke Kanaoka, null Shoichi Ihara, null Kiyoshi Komuta, null Koichiro Asano, null Tsuyoshi Oguma, null Yoko Ito, null Satoru Hashimoto, null Masaki Yamasaki, null Yu Kasamatsu, null Yuko Komase, null Naoya Hida, null Takahiro Tsuburai, null Baku Oyama, null Yuichiro Kitagawa, null Tetsuya Fukuta, null Takahito Miyake, null Shozo Yoshida, null Shinji Ogura, null Minoru Takada, null Hidenori Kanda, null Shinji Abe, null Yuta Kono, null Yuki Togashi, null Hiroyuki Takoi, null Ryota Kikuchi, null Shinichi Ogawa, null Tomouki Ogata, null Shoichiro Ishihara, null Arihiko Kanehiro, null Shinji Ozaki, null Yasuko Fuchimoto, null Sae Wada, null Nobukazu Fujimoto, null Kei Nishiyama, null Mariko Terashima, null Satoru Beppu, null Kosuke Yoshida, null Osamu Narumoto, null Hideaki Nagai, null Nobuharu Ooshima, null Mitsuru Motegi, null Akira Umeda, null Kazuya Miyagawa, null Hisato Shimada, null Mayu Endo, null Yoshiyuki Ohira, null Hironori Sagara, null Akihiko Tanaka, null Shin Ohta, null Tomoyuki Kimura, null Yoko Shibata, null Yoshinori Tanino, null Takefumi Nikaido, null Hiroyuki Minemura, null Yuki Sato, null Yuichiro Yamada, null Takuya Hashino, null Masato Shinoki, null Hajime Iwagoe, null Hiroshi Takahashi, null Kazuhiko Fujii, null Hiroto Kishi, null Tomoo Ishii, null Masayuki Kanai, null Tomonori Imamura, null Tatsuya Yamashita, null Masakiyo Yatomi, null Toshitaka Maeno, null Shinichi Hayashi, null Mai Takahashi, null Mizuki Kuramochi, null Isamu Kamimaki, null Yoshiteru Tominaga, null Mitsuyoshi Utsugi, null Akihiro Ono, null Toru Tanaka, null Takeru Kashiwada, null Kazue Fujita, null Yoshinobu Saito, null Masahiro Seike, null Masahiro Kanai, null Ryunosuke Saiki, null Takayoshi Hyugaji, null Eigo Shimizu, null Kotoe Katayama, null Satoru Miyawaki, null Meiko Takahashi, null Fumihiko Matsuda, null Yosuke Omae, null Yasuhito Nannya, null Takafumi Ueno, null Yuko Kitagawa, null Katsushi Tokunaga, and null The Japan COVID‐19 Task Force

Published
2022

9. Estimating time-series changes in social sentiment @Twitter in U.S. metropolises during the COVID-19 pandemic

Author

Ryuichi Saito and Shinichiro Haruyama

Subjects
Artificial Intelligence, Transportation
Abstract

Since early 2020, the global coronavirus pandemic has strained economic activities and traditional lifestyles. For such emergencies, our paper proposes a social sentiment estimation model that changes in response to infection conditions and state government orders. By designing mediation keywords that do not directly evoke coronavirus, it is possible to observe sentiment waveforms that vary as confirmed cases increase or decrease and as behavioral restrictions are ordered or lifted over a long period. The model demonstrates guaranteed performance with transformer-based neural network models and has been validated in New York City, Los Angeles, and Chicago, given that coronavirus infections explode in overcrowded cities. The time-series of the extracted social sentiment reflected the infection conditions of each city during the 2-year period from pre-pandemic to the new normal and shows a concurrency of waveforms common to the three cities. The methods of this paper could be applied not only to analysis of the COVID-19 pandemic but also to analyses of a wide range of emergencies and they could be a policy support tool that complements traditional surveys in the future.

Published
2022

10. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Author

Qingbo S. Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Ho Lee, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashri Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Kazuto Kato, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, Junya Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, Nobuaki Mori, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Sakamoto Koji, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka-Aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima, Ayumi Yoshifuji, Kazuto Ito, Saeko Takahashi, Kota Ishioka, Morio Nakamura, Makoto Masuda, Aya Wakabayashi, Hiroki Watanabe, Suguru Ueda, Masanori Nishikawa, Yusuke Chihara, Mayumi Takeuchi, Keisuke Onoi, Jun Shinozuka, Atsushi Sueyoshi, Yoji Nagasaki, Masaki Okamoto, Sayoko Ishihara, Masatoshi Shimo, Yoshihisa Tokunaga, Yu Kusaka, Takehiko Ohba, Susumu Isogai, Aki Ogawa, Takuya Inoue, Satoru Fukuyama, Yoshihiro Eriguchi, Akiko Yonekawa, Keiko Kan-o, Koichiro Matsumoto, Kensuke Kanaoka, Shoichi Ihara, Kiyoshi Komuta, Yoshiaki Inoue, Shigeru Chiba, Kunihiro Yamagata, Yuji Hiramatsu, Hirayasu Kai, Koichiro Asano, Tsuyoshi Oguma, Yoko Ito, Satoru Hashimoto, Masaki Yamasaki, Yu Kasamatsu, Yuko Komase, Naoya Hida, Takahiro Tsuburai, Baku Oyama, Minoru Takada, Hidenori Kanda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Shinji Ogura, Shinji Abe, Yuta Kono, Yuki Togashi, Hiroyuki Takoi, Ryota Kikuchi, Shinichi Ogawa, Tomouki Ogata, Shoichiro Ishihara, Arihiko Kanehiro, Shinji Ozaki, Yasuko Fuchimoto, Sae Wada, Nobukazu Fujimoto, Kei Nishiyama, Mariko Terashima, Satoru Beppu, Kosuke Yoshida, Osamu Narumoto, Hideaki Nagai, Nobuharu Ooshima, Mitsuru Motegi, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Mayu Endo, Yoshiyuki Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Tomomi Takano, Kazuhiko Katayama, Masumi Ai, Atsushi Kumanogoh, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, and Yukinori Okada

Subjects
Multidisciplinary, Membrane Glycoproteins, Quantitative Trait Loci, General Physics and Astronomy, COVID-19, General Chemistry, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Japan, Viral infection, Humans, Lectins, C-Type, Gene expression, Receptors, Immunologic, Transcriptomics, Genome-Wide Association Study
Abstract

Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection., 「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.

Published
2021

11. Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan

Author

Shuichi Yoshida, Yoshihiro Hirai, Hiroshi Takahashi, Yoshiyuki Sekikawa, Saeko Takahashi, Yoshitaka Oyamada, Shunsuke Uno, Koutaro Yokote, Kunihiko Takahashi, Shigenari Nukaga, Yoshinao Ono, Shoichiro Ishihara, Nozomu Kimura, Tomohiro Adachi, Shigeki Fujitani, Eri Hagiwara, Motoyuki Suzuki, Tomouki Ogata, Namiki Izumi, Shinji Abe, Etsuko Tagaya, Yoshinori Hasegawa, Yoshimune Miyazaki, Junichi Sasaki, Yoshinori Tanino, Seishi Ogawa, Yuki Togashi, Satoshi Fuke, Yoshiaki Inoue, Hideo Ogata, Masaomi Yamamoto, Hiroshi Saito, Jun Shinozuka, Sho Uchida, Masayoshi Miyawaki, Atsushi Kumanogoh, Koichiro Matsumoto, Yuko Kitagawa, Mayu Endo, Mitsuru Odate, Hiroki Tateno, Fumitake Saito, Mizuki Kuramochi, Shoji Suzuki, Koji Murakami, Kenichi Arakawa, Shozo Yoshida, Hitoshi Sasano, Keigo Kobayashi, Takuro Nii, Takashi Ishiguro, Ryuichi Saito, Yohei Mikami, Takashi Inoue, Haruhiko Kishima, Daisuke Arai, Takao Mochimaru, Minoru Takada, Yuya Ueno, Takehiro Izumo, Reina Hara, Nobuyuki Hizawa, Atsuho Morita, Takanori Hasegawa, Masahiro Seike, Hisako Sageshima, Takeshi Hattori, Shinichi Namba, Shuko Mashimo, Tomoya Tsuchida, Hiromu Tanaka, Naoki Miyazawa, Masatoshi Kawana, Shunichiro Konishi, Takatoshi Enomoto, Takuya Hashino, Hiroki Watanabe, Kentaro Hayashi, Sumito Inoue, Satoshi Hagimoto, Toru Yoshida, Akiko Fujiwara, Masaki Okamoto, Hiroki Kabata, Shuji Tohda, Baku Oyama, Norihiko Takemoto, Nobuyasu Awano, Makoto Hiki, Yasutaka Fukui, Takahiro Fukui, Keisuke Onoi, Yuichiro Yamada, Takayuki Shiroyama, Mayuko Tani, Hiroyuki Muranaka, Kazuhide Ohta, Yoshifumi Kimizuka, Hajime Iwagoe, Yasuko Fuchimo, Hiroki Nakatsumi, Hiroyuki Minemura, Hisatoshi Sugiura, Haruhi Takagi, Hiroyuki Kokuto, Yasuhiro Kimura, Masatoshi Takagaki, Yuki Sato, Masao Hagihara, Junko Kagyo, Yusuke Kawamura, Sayoko Ishihara, Akinori Kimura, Aki Ogawa, Hironori Sagara, Noa Sasa, Masahiro Kanai, Isano Hase, Takenori Okada, Akiyoshi Nakayama, Osamu Narumoto, Norihito Omote, Kazunori Tomono, Toshiro Sato, Hatsuyo Takaoka, Mayumi Takeuchi, Keiko Kan-o, Satoshi Okamori, Yukinori Okada, Yoshito Takeda, Kazuto Ito, Tatsuhiko Naito, Reina Hayashi, Toshikatsu Sado, Kazuya Ichikado, Yasushi Matsushita, Nobuaki Mori, Takashi Nishida, Toshitaka Maeno, Tomomi Takano, Soichiro Ueda, Tomoyasu Nishimura, Masaru Nishitsuji, Ryusuke Anan, Arihiko Kanehiro, Akira Umeda, Syuji Kanayama, Yosuke Omae, Tomoki Nagasaka, Koichi Nishi, Yoshiyuki Ohira, Fumimaro Ito, Toru Tanaka, Kenichiro Takahashi, Hidenori Kanda, Hidenori Inohara, Kaoru Nagata, Kei Nishiyama, Masafumi Watanabe, Katsunori Masaki, Ryuzo Abe, Hirofumi Kamata, Masahiro Harada, Chihiro Tani Sassa, Tomoya Sano, Shoichi Ihara, Tadashi Manabe, Takafumi Ueno, Takahito Fukusumi, Meiko Takahashi, Kyuto Sonehara, Kana Sasaki, Hiroyuki Takoi, Chie Watanabe, Takahiro Tsuburai, Tomonori Sato, Yoichi Kobayashi, Kazuhisa Takahashi, Yasushi Nakano, Kenichi Yamamoto, Takayoshi Hyugaji, Hirohito Sano, Ho Namkoong, Atsushi Sueyoshi, Naoya Ichimura, Yoshiteru Tominaga, Masaru Amishima, Ken Suzuki, Ken Ohta, Shigehiro Hagiwara, Masayuki Kanai, Kota Hoshino, Shuhei Kawabata, Mitsuhiro Yamada, Toshio Naito, Akihiro Ono, Yotaro Takaku, Yoko Sato, Satoru Miyano, Junichi Ochi, Yoshikazu Mutoh, Hiroaki Baba, Yoko Shibata, Tatsuya Yamashita, Yoko Ito, Hiromu Iwamura, Munehisa Fukushima, Saori Amiya, Takayuki Honda, Yuta Kono, Susumu Isogai, Ryuya Edahiro, Makoto Masuda, Hisato Shimada, Hideaki Nagai, Tomoya Baba, Fukuki Saito, Toshihiro Sakurai, Ryota Kikuchi, Yoichiro Noguchi, Tatsuhiko Anzai, Mizuha Hashiguchi, Masamichi Sato, Naoki Hasegawa, Yasunari Miyazaki, Tetsuya Ueda, Yasuhiko Yamano, Shinji Ozaki, Yoshinobu Saito, Takuya Inoue, Sohei Nakayama, Sawako Arai, Yu Kusaka, Miki Kawada, Yuko Kurihara, Daiki Wada, Isamu Kamimaki, Motonao Ishikawa, Sumiko Kohashi, Sae Wada, Kazuma Yagi, Rino Ishihara, Hiroko Okabayashi, Nobuhiro Kodama, Mai Takahashi, Kiyoshi Komuta, Yusuke Chihara, Yoshihiko Nakamura, Akifumi Endo, Shuichiro Matsumoto, Akira Igarashi, Shuhei Yamada, Akiko Yonekawa, Yukiko Nakajima, Sakamoto Koji, Kazue Fujita, Masakiyo Yatomi, Makoto Ishii, Ryuji Koike, Eigo Shimizu, Shigeru Chiba, Satoru Miyawaki, Shunsuke Maeda, Toshio Odani, Hideyasu Sugimoto, Masanori Nishikawa, Yoshinori Yasui, Akira Ando, Takayuki Shibusawa, Nobuharu Ooshima, Toshiyuki Kita, Satoru Fukuyama, Ai Tada, Mariko Terashima, Tadao Nagasaki, Rie Baba, Atsuya Narita, Takanori Ogawa, Tetsuo Shimizu, Ken Ueda, Yuki Haruta, Satoru Hashimoto, Ryohei Suematsu, Ho Lee, Ryosuke Satomi, Hirotaka Eguchi, Kota Ishioka, Ryousuke Aoki, Yusuke Suzuki, Takemasa Matsumoto, Kazunari Sonobe, Hisato Hiranuma, Hirayasu Kai, Kosuke Yoshida, Ayumi Yoshifuji, Takeru Kashiwada, Yuko Harada, Reoto Takei, Aya Wakabayashi, Tomohiro Matsunaga, Haruhiko Hirata, Hiroshi Morisaki, Yoshifumi Uwamino, Yoshihisa Tokunaga, Kazuki Niwa, Hidetoshi Kawashima, Hideki Terai, Kenji Takano, Mumon Takita, Yuko Komase, Masaki Yamasaki, Chiaki Hosoda, Takayuki Ogura, Shun Shibata, Mitsuru Motegi, Takeshi Takahashi, Takehiko Ohba, Shinichi Hayashi, Satoshi Ito, Yu Kasamatsu, Shinnosuke Ikemura, Tetsuya Fukuta, Koichiro Asano, Taka-aki Nakada, Kota Murohashi, Tomoyuki Uchida, Hirotaka Matsuo, Satoko Hanada, Kenta Nishiyama, Minoru Inomata, Nobukazu Fujimoto, Tomoya Tateishi, Mitsuaki Kojima, Kazuto Kato, Kazuhiko Katayama, Yuichi Maeda, Takashi Kagaya, Keiko Wakahara, Takashi Ogura, Yasuhiro Gon, Taku Oshima, Ken Arimura, Shuhei Maruyama, Mari Tone, Ryuichi Sato, Koichi Fukunaga, Hidefumi Koh, Yuichiro Kitagawa, Noboru Takayanagi, Masatoshi Miyazaki, Ichiro Nakachi, Akihiko Kawana, Toshiyuki Hirano, Yohei Funatsu, Yasushi Nakamori, Reiko Sado, Yasuo Shichinohe, Junya Suzuki, Yasunari Kaneyama, Takahito Miyake, Kunihiro Yamagata, Yasuhito Nannya, Shinichi Ogawa, Naoya Hida, Tsuyoshi Oguma, Kazunori Nakamura, Kosaku Nanki, Naozumi Hashimoto, Fumihiko Matsuda, Tomoyuki Kimura, Daiki Morikawa, Yuji Uchimura, Yoshiaki Tanaka, Kazuhisa Yoshiya, Takashige Kuraki, Yoshihiro Eriguchi, Tomohisa Shoko, Tadanaga Shimada, Yuji Hiramatsu, Akihiko Tanaka, Hideya Kitamura, Yutaka Kozu, Ryosuke Arai, Taisuke Isono, Yasushi Makino, Seiya Imoto, Yuichi Adachi, Yuma Matsui, Masato Shinoki, Kazumi Nishio, Keiko Mitamura, Tomonori Imamura, Masanori Azuma, Sonoko Harada, Hiroshi Ono, Kotoe Katayama, Masumi Ai, Keisuke Shinozuka, Reiko Taki, Junichi Maruyama, Takao Imai, Yutaro Kaneko, Kensuke Kanaoka, Sho Ota, Yoji Nagasaki, Toshihiro Kishikawa, Takayuki Niitsu, Hirohisa Horinouchi, Naoyuki Kuse, Tetsuya Shiomi, Jun Nakajima, Katsushi Tokunaga, Norihiro Harada, Keita Masuzawa, Noriyuki Kijima, Takeshi Osawa, Satoru Sakagami, Kazuhiko Fujii, Shotaro Chubachi, Tomoyuki Yoshihara, Yoshimi Noda, Hiroyasu Ishikura, Kiyoshi Koshida, Shin Ohta, Ai Nakamura, Naota Kuwahara, Shinji Ogura, Suguru Ueda, Akihiro Ito, Morio Nakamura, Tohru Takata, Yuya Shirai, Hidenori Takahashi, Eriko Yoshida, Satoru Beppu, Mitsuyoshi Utsugi, Masafumi Shimoda, Masatoshi Shimo, Tomoo Ishii, Takefumi Nikaido, Takanori Asakura, Kazuya Miyagawa, Takanori Kanai, Hiroto Kishi, Akane Kamiya, Genta Nagao, Kodai Kawamura, Ryunosuke Saiki, Takashi Yoshiyama, Hajime Sasano, Kazuyoshi Watanabe, and Yuta Matsubara

Subjects
Genetics, education.field_of_study, Population, Mendelian Randomization Analysis, Genome-wide association study, Odds ratio, Biology, medicine.disease, Obesity, Confidence interval, Minor allele frequency, Pandemic, medicine, education
Abstract

To elucidate the host genetic loci affecting severity of SARS-CoV-2 infection, or Coronavirus disease 2019 (COVID-19), is an emerging issue in the face of the current devastating pandemic. Here, we report a genome-wide association study (GWAS) of COVID-19 in a Japanese population led by the Japan COVID-19 Task Force, as one of the initial discovery GWAS studies performed on a non-European population. Enrolling a total of 2,393 cases and 3,289 controls, we not only replicated previously reported COVID-19 risk variants (e.g., LZTFL1, FOXP4, ABO, and IFNAR2), but also found a variant on 5p35 (rs60200309-A at DOCK2) that was significantly associated with severe COVID-19 in younger (-8 (odds ratio = 2.01, 95% confidence interval = 1.58-2.55). This risk allele was prevalent in East Asians, including Japanese (minor allele frequency [MAF] = 0.097), but rarely found in Europeans. Cross-population Mendelian randomization analysis made a causal inference of a number of complex human traits on COVID-19. In particular, obesity had a significant impact on severe COVID-19. The presence of the population-specific risk allele underscores the need of non-European studies of COVID-19 host genetics.

Published
2021

12. Intestinal F‐box protein regulates quick avoidance behavior of Caenorhabditis elegans to the pathogenic bacterium Pseudomonas aeruginosa

Author

Motomichi Doi, Ryuichi Saito, and Yoichi Shinkai

Subjects
Mutant, medicine.disease_cause, p38 Mitogen-Activated Protein Kinases, F-box protein, 03 medical and health sciences, Immune system, Avoidance Learning, Genetics, medicine, Animals, Intestinal Mucosa, Caenorhabditis elegans, Caenorhabditis elegans Proteins, 030304 developmental biology, Neurons, 0303 health sciences, biology, Pseudomonas aeruginosa, F-Box Proteins, Pathogenic bacteria, Cell Biology, biology.organism_classification, Cell biology, biology.protein, Signal transduction, Function (biology)
Abstract

In most animals, avoiding pathogenic bacteria is crucial for better health and a long life span. For this purpose, animals should be able to quickly sense the presence or uptake of pathogens. The intestine could be a candidate organ to induce escape behaviors; however, the intestinal signaling mechanism for acute regulation of neuronal activity is not well understood. Here, we show that adult Caenorhabditis elegans can respond to the pathogenic bacterium Pseudomonas aeruginosa within 30 min of exposure. This behavior was much faster than previously observed avoidance behaviors in response to P. aeruginosa. By genetic screening, we isolated a mutant defective in this quick avoidance behavior and found that the novel F-box protein FBXC-58 is involved. FBXC-58 is expressed in several tissues, but defective avoidance was rescued by expression of the protein in the intestine. Interestingly, we also found that some but not all mutants in the p38-MAPK and insulin-like signaling pathways, which function in the immune response to pathogens in the intestine, were defective in the quick avoidance behavior to P. aeruginosa. These results suggest that a novel signaling pathway in the intestine exists to regulate neuronal activity for a quick behavioral response.

Published
2019

14. Immune Profile Analysis in Peripheral Blood and Tumor in Patients with Malignant Melanoma

Author

Yu Sawada, Ryuichi Saito, and Motonobu Nakamura

Subjects
CD4-Positive T-Lymphocytes, 0301 basic medicine, Skin Neoplasms, medicine.medical_treatment, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, B7-H1 Antigen, lcsh:Chemistry, 0302 clinical medicine, Immune Checkpoint Inhibitors, lcsh:QH301-705.5, Spectroscopy, B-Lymphocytes, biology, Melanoma, General Medicine, Computer Science Applications, medicine.anatomical_structure, Cytokine, 030220 oncology & carcinogenesis, Cytokines, Immunotherapy, Antibody, Nivolumab, Signal Transduction, anti-PD1 antibody, Spleen, macromolecular substances, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Immune system, immune cells, medicine, melanoma, Humans, Physical and Theoretical Chemistry, Molecular Biology, neoplasms, immune checkpoint, nivolumab, business.industry, Organic Chemistry, Dendritic Cells, HLA-DR Antigens, medicine.disease, Immune checkpoint, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, biology.protein, Cancer research, business, CD8
Abstract

Melanoma is a severe and life-threatening malignancy derived from melanocytes. The traditional treatment for melanoma could not sustain satisfactory outcomes long term, however, the recent immune checkpoint treatment has made a breakthrough in these problems. Nivolumab is a representative immune checkpoint treatment, and this PD-1-targeted therapy has evolutionally developed and improved the clinical outcome in a recent decade. On the other hand, the clinical application of immune checkpoint treatment presents clinicians with novel questions, especially how to obtain additional efficacy and overcome the disadvantage by using this treatment. To answer these problems, we first investigated the distribution of PD-L1 in various organs to clarify the organs most affected by anti-PD-1 antibody treatment. Among various organs, lung, placenta, spleen, heart, and thyroid highly expressed PD-L1, while skin, thalamus, hippocampus, ovary, stomach, testis, and prostate showed lower expressions of PD-L1. Furthermore, the immune profiles were also examined in tumors and peripheral blood in patients with melanoma. PD-1 was highly expressed in CD8 and CD4 cells, and B cells also highly expressed PD-1 compared with NK cells. However, there was no significant difference in Th1/Th2/Th17 cytokines and inhibitory cytokine IL-10. Although nevus showed a low expression of PD-L1 compared with healthy skin, PD-L1 expression was increased in growth-phase melanoma. Finally, we analyzed the peripheral blood profiles in patients treated with nivolumab. PD-1-bearing dendritic cells (DCs) were increased during nivolumab treatment and Lin-CD11c+HLA-DR+ cells were highly increased during nivolumab treatment. These findings indicate a clue to answering the problems during nivolumab treatment and suggest to us the importance of multiple aspect observation during immune checkpoint treatment.

Published
2021
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15. Two cases of eczematous drug eruption caused by oral tacrolimus administration

Author

Ryuichi Saito, Motonobu Nakamura, and Yu Sawada

Subjects
medicine.medical_specialty, business.industry, Dermatology, medicine.disease, Tacrolimus, Drug eruption, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Anesthesia, Immunology and Allergy, Medicine, Eczematous drug eruption, business, Administration (government)
Published
2017

17. Profile fluctuation of peripheral blood in advanced melanoma patients treated with nivolumab

Author

Shun Ohmori, Etsuko Okada, Motonobu Nakamura, Ryuichi Saito, Haruna Yoshioka, Kayo Yamamoto, Manabu Yoshioka, Yu Sawada, and Natsuko Saito-Sasaki

Subjects
0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Dermatology, Peripheral blood mononuclear cell, Flow cytometry, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Antineoplastic Agents, Immunological, Th2 Cells, Internal medicine, medicine, Biomarkers, Tumor, Humans, Melanoma, Advanced melanoma, Aged, Aged, 80 and over, medicine.diagnostic_test, biology, business.industry, General Medicine, Middle Aged, Th1 Cells, medicine.disease, Flow Cytometry, Peripheral blood, 030104 developmental biology, Metastatic malignant melanoma, Nivolumab, Treatment Outcome, biology.protein, Female, Antibody, business, T-Lymphocytes, Cytotoxic
Abstract

Melanoma is a malignant tumor of the melanocytes with an unfavorable clinical behavior. Nivolumab, a representative anti-programmed death 1 (PD-1) antibody, has recently been used for the treatment of metastatic malignant melanoma. However, there have been few appropriate biomarkers predicting the effect of nivolumab before the administration. Furthermore, the detailed characteristics of peripheral blood mononuclear cell (PBMC) profiles during nivolumab treatment remains unclear. In this study, we investigated fluctuations of PBMC profile during nivolumab treatment. PBMC analysis showed T-helper (Th)2-dominant conditions after a first course of nivolumab treatment. In a favorable case treated with nivolumab, a Th1/T-cytotoxic 1 shift was observed after nivolumab was administrated. These results suggest that flow cytometric analysis of PBMC may be helpful for the treatment of nivolumab.

Published
2018

19. Vehicle-Level EMC Modeling for HEV/EV Applications

Author

Hiroki Funato, Hua Zeng, Masayoshi Takahashi, William T. Ivan, Andrew Baker, Ryuichi Saito, Isao Hoda, Jia Li, Syed Md Jaffrey Al Kadry, and Hideyuki Sakamoto

Subjects
Physics, Control and Systems Engineering, Automotive Engineering, Electromagnetic compatibility, Electrical and Electronic Engineering, Safety, Risk, Reliability and Quality, Automotive engineering
Published
2015

21. Identification of a natural recombination in the F and H genes of feline morbillivirus

Author

Shigeru Morikawa, Nami Kubota, Tetsuya Furuya, Keiji Maruyama, Michio Suzuki, Koichi Imaoka, Hiroshi Mizutani, Ryuichi Saito, Masanobu Kimura, Tetsuya Mizutani, and Eun-Sil Park

Subjects
Gene Expression Regulation, Viral, Biology, Cat Diseases, Virus, law.invention, Viral Proteins, Hemagglutinin protein, Japan, Phylogenetics, law, Polymorphism (computer science), Virology, Animals, Gene, Phylogeny, Feline morbillivirus, Genetics, Polymorphism, Genetic, Base Sequence, Phylogenetic tree, Strain (biology), Recombination, Morbillivirus, Cats, Recombinant DNA, Hong Kong, Fusion protein, Morbillivirus Infections, Reassortant Viruses
Abstract

Feline morbillivirus (FmoPV) has recently been identified in Hong Kong and Japan. FmoPV is considered to belong to the genus Morbillivirus, in the family Paramyxoviridae. In this study, the complete nucleotide sequences of three strains of FmoPV detected in cats in Japan were determined. Among the six genes in FmoPV; N, P/V/C, M, F, H and L, the P gene showed the highest polymorphism in the nucleotide and putative amino acid sequences among the FmoPV strains. There was no geographical association in terms of the FmoPV phylogeny; however, from extensive phylogenetic and recombination analyses, we found that one Japanese FmoPV strain, MiJP003, was a probable recombinant between two virus strains in the independent lineages found in Japan and Hong Kong, respectively. The recombination was considered to have occurred within the F and H genes. Such recombination is thought to be involved in the evolution of FmoPV.

Published
2014
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22. Characterization and storage of radioactive zeolite waste

Author

Yasuhiro Tsubata, Hisashi Fukushima, Shinsuke Tashiro, Yu Kamiji, Mark S. Denton, Seichi Sato, Kenji Nishihara, Ryutaro Hino, Atsuhiko Terada, Wenjun Ji, Ryuichi Saito, Hiroyuki Sato, Junichi Nakano, Ryuji Nagaishi, Chiaki Kato, Isao Yamagishi, Tomonori Satoh, and Keisuke Morita

Subjects
Nuclear and High Energy Physics, Waste management, Ion exchange, business.industry, Cryo-adsorption, Radiochemistry, chemistry.chemical_element, Nuclear power, Saline water, Fukushima daiichi, Nuclear Energy and Engineering, chemistry, Caesium, business, Zeolite, Hydrogen production
Abstract

For the safe storage of zeolite wastes generated by the treatment of radioactive saline water at the Fukushima Daiichi Nuclear Power Station, this study investigated the fundamental properties of h...

Published
2014

24. Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan

Author

Hidemi Kasai, Hiroshi Mizutani, Nami Kubota, Jungo Okajima, Koichi Imaoka, Eun-Sil Park, Noriko Nakajima, Keiji Maruyama, Ryuichi Saito, Masanobu Kimura, Yuko Sato, Shigeru Morikawa, Youko Hasuike, and Michio Suzuki

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, 040301 veterinary sciences, Epidemiology, Inflammation, Antibodies, Viral, Cat Diseases, Kidney, 0403 veterinary science, 03 medical and health sciences, Morbillivirus, Japan, medicine, Animals, Humans, Fluorescent Antibody Technique, Indirect, Feline morbillivirus, CATS, General Veterinary, biology, business.industry, RNA, Cat, 04 agricultural and veterinary sciences, General Medicine, Kidney disease, biology.organism_classification, medicine.disease, veterinary(all), Virology, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Cats, Immunohistochemistry, Nephritis, Interstitial, RNA, Viral, medicine.symptom, Antibody, business, Morbillivirus Infections, Research Article, HeLa Cells
Abstract

Background Feline morbillivirus (FmoPV) is a novel paramyxovirus found to infect domestic cats. FmoPV has been isolated in several countries in Asia and Europe and is considered to have genetic diversity. Also, it is suspected to be associated with feline renal diseases including tubulointerstitial nephritis (TIN), which affects domestic cats with a high incidence rate. Results To clarify the state of FmoPV infection among domestic cats in Japan, an epidemiological survey was conducted. Twenty-one out of 100 cats were found to have serum antibodies (Ab) against FmoPV-N protein by indirect immunofluorescence assay (IF) using FmoPV-N protein-expressing HeLa cells. Twenty-two of the cats were positive for FmoPV RNA in the urine and/or renal tissues. In total, 29 cats were positive for Ab and/or viral RNA. These FmoPV-infected cats were classified into three different phases of infection: RNA+/Ab + (14 cats), RNA+/Ab- (8 cats) and RNA-/Ab + (7 cats). In immunohistochemistry (IHC), 19 out of 29 cats were positive for FmoPV-N protein in kidney tissues; however, the FmoPV-N protein was located in the inflammatory lesions with severe grade in only four out of the 19 cats. Since 15 out of 29 infected cats were positive for viral RNA and Ab, approximately half of the infected cats were persistently infected with FmoPV. Conclusions A statistically significant difference was observed between infection of FmoPV and the presence of inflammatory changes in renal lesions, indicating a relationship between FmoPV infection and feline renal diseases. However, we could not obtain histopathological evidence of a relationship between FmoPV infection and TIN.

Published
2016
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25. A Direct Sensing Current Transformer for the Vehicle Inverter

Author

Koichi Yahata, Kinya Nakatsu, and Ryuichi Saito

Subjects
Isolation transformer, Materials science, Mechanical Engineering, Flyback transformer, Electronic engineering, Inverter, Grid-tie inverter, Electrical and Electronic Engineering, Distribution transformer, Delta-wye transformer, Current transformer
Published
2013

26. Compact and high power inverter for the Cadillac CT6 rear wheel drive PHEV

Author

Ryuichi Saito, Peter J. Savagian, Takeshi Matsuo, Mehrdad Teimor, and Mohammad N. Anwar

Subjects
Engineering, business.product_category, business.industry, Busbar, Power inverter, 05 social sciences, Electrical engineering, 020302 automobile design & engineering, 02 engineering and technology, Battery pack, Traction motor, 0203 mechanical engineering, Power module, Electric vehicle, Inverter, 0501 psychology and cognitive sciences, Power semiconductor device, business, 050107 human factors
Abstract

Electric drive system for the Cadillac CT6 plug-in hybrid electric vehicle (PHEV) comprises a power-split hybrid transmission utilizing two motors, a traction power inverter module (TPIM) having two inverters and a liquid-cooled lithiumion battery pack [1, 2]. The resulting propulsion system provides a combination of exceptional fuel economy, crisp acceleration, and strong electric-only driving range. To meet all these performance, reliability and robustness targets and package the TPIM into a compact under hood environment is a challenge. This paper describes indispensable and collaborative design efforts by Hitachi Automotive and General Motors to meet this challenge. Enhancing heat dissipation performance and using high efficient power semiconductor enables reduced inverter size and increased power output. Elimination of heat impeding thermal grease and developing direct water cooled power module made generational improvements in this area. Hitachi went further by developing a direct double-sided cooling power module to achieve ∼35% improvement in heat dissipation utilizing a proprietary cooling structure that immerses the module in coolant [3]. This paper elaborates on the integration, structure and the selection of power transistor switch for this TPIM to meet Cadillac CT6 PHEV tractive and special maneuver needs. Among other coherent steps are to design low inductance busbar, optimize the gate drive circuit elements, provide protection functions for detecting over-temperature, over-current, over-voltage ranges and thus maximizing the performance from the power devices. Design efforts were also directed to surround the Bulk DC capacitor by the vertical water channels of the power module and maintain life expectancy by not exceeding rated hot spot temperature. This paper describes predictions, component and vehicle level test results to justify design competence.

Published
2016

27. Drug eruption caused by memantine

Author

Motonobu Nakamura, Shun Ohmori, Ryuichi Saito, Etsuko Okada, Takashi Yamaguchi, Manabu Yoshioka, Yu Sawada, and Sanehito Haruyama

Subjects
Male, Pulmonary and Respiratory Medicine, Immunology, Pharmacology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Memantine, medicine, Humans, Immunology and Allergy, 030212 general & internal medicine, Cholinesterase, Aged, 80 and over, biology, business.industry, medicine.disease, Drug eruption, Excitatory Amino Acid Antagonists, biology.protein, Cholinesterase Inhibitors, Drug Eruptions, business, medicine.drug
Published
2017

28. Design and Synthesis of Diphosphine Ligands Bearing an Osmium(II) Bis(terpyridyl) Moiety as a Light-Harvesting Unit: Application to Photocatalytic Production of Dihydrogen

Author

Haruyuki Nakanishi, Kouitsu Sasaki, Yoshihiro Miyake, Kazunari Nakajima, Ryuichi Saito, and Yoshiaki Nishibayashi

Subjects
Inorganic Chemistry, Denticity, chemistry, Stereochemistry, parasitic diseases, Organic Chemistry, Polymer chemistry, Photocatalysis, Moiety, chemistry.chemical_element, Osmium, Physical and Theoretical Chemistry, Rhodium
Abstract

We have designed and prepared novel diphosphine ligands bearing an Os(tpy)22+ moiety as a light-harvesting unit and have found that these diphosphine ligands coordinate to the rhodium atom in a bidentate manner. The rhodium complexes including diphosphine ligands bearing an Os(tpy)22+ moiety have been revealed to work as an effective photocatalyst for the production of dihydrogen.

Published
2009

29. Al2O3-MgO-ReOx (Re: Rare Earth)-Based LTCC and its Application to Multilayer Non-Shrinkage Substrate for Microwave Devices

Author

Hidenori Katsumura, Ryuichi Saito, and Hiroshi Kagata

Subjects
Materials science, Flatness (systems theory), Sintering, Substrate (electronics), Dielectric, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Flexural strength, Mechanics of Materials, Materials Chemistry, Ceramics and Composites, Electrical and Electronic Engineering, Composite material, Temperature coefficient, Microwave, Shrinkage
Abstract

We studied the dielectric properties of Al2O3-MgO-ReO x (Re: rare earth) systems in the microwave region and found that the magnetoplumbite phases in the MgO-poor regions of MgReAl11O19 (Re: La ∼ Tb) compositions had positive TCF (temperature coefficient of resonance frequency) values in spite of having low dielectric constants of under 20. By mixing a lead-free glass with the above system, a novel LTCC (which we term an AMSG) was obtained that was characterized by a low dielectric constant (< 10), a near zero TCF, and high bending strength. When firing these AMSG green sheets inserted between HTCC alumina or magnesia green sheets that cannot be sintered at the AMSG sintering temperature, the AMSG sheets were seen to shrink not in the x-y directions but in the z direction due to the constraining effects of the HTCC layers. The obtained non-shrinkage substrate had precise dimensions and a high degree of flatness. The AMSG and the non-shrinking techniques have potential for application to integrated RF modules in mobile communications equipment.

Published
2004

30. Al2O3-MgO-ReOx (Re: rare earth) based LTCC and Non-shrinkage Firing Process

Author

Hidenori Katsumura, Ryuichi Saito, and Hiroshi Kagata

Subjects
Materials science, Mechanical Engineering, Flatness (systems theory), Metals and Alloys, Sintering, Mineralogy, Substrate (electronics), Dielectric, Industrial and Manufacturing Engineering, Flexural strength, visual_art, Materials Chemistry, visual_art.visual_art_medium, Ceramic, Composite material, Temperature coefficient, Microwave
Abstract

Dielectric properties of Al2O3-MgO-ReOx (Re: rare earth) systems in the microwave region have been studied. We found that the magnetoplumbite phases in the MgO-poor regions of MgReAl11O19(Re: La-Tb) compositions had positive TCF (temperature coefficient of resonance frequency) values in spite of having low dielectric constants of under 20. By mixing a lead-free glass with the Al2O3-MgO-Sm2O3 system, a novel LTCC which we term an AMSG (which A represents Al2O3, M represents MgO, S represents Sm2O3, and G represents glass) was obtained that was characterized by a low dielectric constant (

Published
2004

31. Alternative Approach Based on ^|^ldquo;Occlusal Examination^|^rdquo; to ^|^ldquo;Toothache^|^rdquo; without Inflamatory Signs. ^|^ldquo;A Clinical Research^|^rdquo;

Author

Tamotsu Kojima, Atsuko Komesu, Tsutomu Tawaragi, Shinko Koizumi, Ikuo Suzuki, Hiroshi Fujihashi, Toshihiko Yajima, Yoshiyuki Saito, Ryuichi Saito, Shinichi Hashimoto, Kiyonobu Muramoto, Kenji Kurogome, Masahiro Matsuzaki, Kazuhiko Okamoto, and Kayo Tanaka

Subjects
business.industry, Toothache, Medicine, Dentistry, medicine.symptom, business
Published
2003

32. The next-generation high power density inverter technology for vehicle

Author

Ryuichi Saito and Kinya Nakatsu

Subjects
Electric power system, Engineering, business.industry, Power electronics, Power module, Single-phase electric power, Electric power, Hybrid power, business, Automotive engineering, Maximum power point tracking, Efficient energy use
Abstract

Realizing a sustainable society will require a reduction in CO2 emissions, and many different sectors of the economy are being encouraged to be energy efficient, including the electric power business, industry, and consumer and transportation businesses. In the transportation sector in particular, environmentally conscious vehicles that use power electronics will be essential as replacements for conventional vehicles powered by internal combustion engines. The main components used in power electronics include inverters, batteries, and electric motors, and we are working on the development of specific technologies intended to make these components even smaller and more efficient than before. In this article, we describe the physical circuit designs needed to make the inverters used for controlling large electric power systems more efficient and techniques that achieve a high level of reliability, including cooling and vibration resistance.

Published
2014

33. A novel direct water and Double-Sided Cooled Power Module for HEV/EV inverter

Author

Atsuo Nishihara, Kinya Nakatsu, Koji Sasaki, Ryuichi Saito, and Takeshi Tokuyama

Subjects
Engineering, business.industry, Thermal resistance, medicine.medical_treatment, Electrical engineering, Traction (orthopedics), Coolant, Current injection technique, Power module, Thermal, medicine, Inverter, business, Power density
Abstract

Direct Water and Double-Sided Cooled Power Modules (DWDSCPM) are especially attractive due to high thermal performances. The DWDSCPM was able to reduce the thermal resistance by 50% and increase power density of the traction inverter by 70% in comparison with a conventional power module.

Published
2014

34. 3.6 kV 4H-SiC JBS Diodes with Low RonS

Author

Ryuichi Saito, Katsunori Asano, and Yoshitaka Sugawara

Subjects
Materials science, Mechanics of Materials, business.industry, Mechanical Engineering, Schottky barrier, Optoelectronics, Schottky diode, General Materials Science, Condensed Matter Physics, Metal–semiconductor junction, business, Diode, Step recovery diode
Published
2000

35. SUBCAPSULAR HEMATOMA OF THE LIVER AFTER EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY

Author

Ryuichi Saito, Kazuki Kobayashi, Akira Iwasaki, and Eiichi Ishizuka

Subjects
Hematoma, medicine.medical_specialty, Routine ultrasound, business.industry, Liver Diseases, Urology, medicine.medical_treatment, Right renal, Middle Aged, medicine.disease, Subcapsular Hematoma, Extracorporeal shock wave lithotripsy, Preoperative examination, Kidney Calculi, Lithotripsy, medicine, Humans, Female, Radiology, Liver function, Tomography, X-Ray Computed, Complication, business, Ultrasonography
Abstract

We experienced a case of a hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL) for a right renal stone. To our knowledge this presentation is the second case in the Japanese literature. A 63-year-old female with a right renal stone received 2,800 shots of 14.0 kilo-volts shockwave with Sonolith 3,000. Preoperative examination of the blood disclosed no abnormalities in the coagulating system except slight reduction of platelet count and slight impairment of liver function. Postoperative routine ultrasound echograms revealed a hepatic subcapsular hematoma although she had no symptom. The size of the hematoma measured 11.0 x 5.0 cm in computed tomograms (CT). She was carefully observed without any treatments because the hematoma did not increase in size. CT scans 6 months after the ESWL treatment demonstrated neither hematoma nor masses in the liver. As a complication of ESWL for urolithiasis a hepatic subcapsular hematoma is very rare. We herein presented the case and discussed the complications of ESWL briefly in the literature.

Published
1998

37. A novel direct water and double-sided cooled power module and a compact inverter for electrified vehicles

Author

Ryuichi Saito, Kinya Nakatsu, Atsuo Nishihara, and Koji Sasaki

Subjects
Engineering, business.industry, medicine.medical_treatment, Power module, Thermal resistance, Thermal, medicine, Electrical engineering, Inverter, Traction (orthopedics), business, Maximum power point tracking, Power density
Abstract

Direct Water and Double-Sided Cooled Power Modules (DWDSCPM) are especially attractive due to high thermal performances. The DWDSCPM was able to reduce the thermal resistance by 50% and increase power density of the traction inverter by 70% in comparison with a conventional power module.

Published
2013

38. Duodenal Adenoma Removed by Endoscopic Polypectomy

Author

Ryuichi Saito, Akihiko Arakawa, Tetsuya Matsukawa, Junji Tsuruta, Mutsumasa Takahashi, Joji Urata, Yoshiya Ogata, and Tadatoshi Tsuchigame

Subjects
medicine.medical_specialty, Gastrointestinal tract, Adenoma, business.industry, Gastroenterology, Malignancy, medicine.disease, digestive system, digestive system diseases, Surgery, Endoscopic polypectomy, Duodenal Adenoma, surgical procedures, operative, medicine.anatomical_structure, Posterior wall, Internal medicine, otorhinolaryngologic diseases, Duodenum, medicine, Radiology, Nuclear Medicine and imaging, business
Abstract

We report two duodenal adenoma cases treated by endoscopic polypectomy. Case 1, a 59-year-old male, visited our hospital for further examination of a duodenal polyp found elsewhere. X-ray examination revealed a semi-pedunculated polyp with an irregular surface in the second portion of the posterior wall of the duodenum. Case 2, a 68-year-old male, was admitted to our hospital for endoscopic polypectomy of a duodenal polyp. Upper GI series demonstrated a semi-pedunculated round polyp with a shallow central depression. Endoscopic polypectomy was performed for both lesions and the polyps were successfully removed. The resected polyps were 11 × 10 mm and 13 × 12 mm in size, respectively. The polyps were histologically diagnosed as tubulovillous and tubular adenomas, respectively, with no evidence of malignancy. Endoscopic polypectomy provides histological confirmation of adenoma of the gastrointestinal tract, and it is frequently applicable to the duodenum.

Published
1995

39. Clinical evaluation of gastric fundic gland polyps without familial polyposis coli

Author

M. Takahashi, Akihiko Arakawa, Tadatoshi Tsuchigame, Mitsuhiro Furusawa, Sukeyoshi Ueno, Joji Urata, Yoshiya Ogata, Tetsuya Matsukawa, and Ryuichi Saito

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Adolescent, Urology, digestive system, Gastroenterology, Endoscopy, Gastrointestinal, Polyps, Fundic gland polyposis, Stomach Neoplasms, Internal medicine, Gastrins, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Gastric Fundus, Aged, Radiological and Ultrasound Technology, medicine.diagnostic_test, Gastric fundus, business.industry, Familial polyposis coli, General Medicine, Middle Aged, Radiological examination, Hepatology, medicine.disease, digestive system diseases, Endoscopy, Radiography, Fundic Gland Polyp, Adenomatous Polyposis Coli, Gastric Mucosa, Female, business, Clinical evaluation
Abstract

Assessments were made of 63 cases of fundic gland polyposis (FGP) unassociated with adenomatosis coli. These cases were evaluated by radiological examination over 2 years follow-up. All polyps were pathologically confirmed by endoscopic biopsies.Most cases were asymptomatic when diagnosed during mass radiological surveys of the upper gastrointestinal tract. The majority of patients ranged in age from 40-60 years, and the polyps numbered fewer than 20 in 55 cases (87.3%). Polyps were detected in the fundic glands using the congo red test and by biopsies.All serum gastrin values were within the normal range. During the course of this study, the polyps of 13 cases (20.6%) increased and those of three cases (4.8%) decreased or resolved completely.From these findings it is considered that FGP are observed in stomachs with less atrophy, and that polyps follow courses in which they increase, decrease, disappear, along with atrophy.

Published
1995

40. Bonding mechanism between Sn-Sb solder and evaporated multilayers

Author

Yasutoshi Kurihara and Ryuichi Saito

Subjects
Materials science, Computer Networks and Communications, Diffusion, Metallurgy, Intermetallic, General Physics and Astronomy, Substrate (electronics), Adhesion, Metal, Soldering, visual_art, visual_art.visual_art_medium, Silicon chip, Electrical and Electronic Engineering, Layer (electronics)
Abstract

This paper discusses the behavior of metal and the bonding mechanism at the interface between Sn-Sb solder and an evaporated Al-Cr-Ni-Ag multilayer used for bonding a silicon chip to a substrate. As the treatment temperature increases, alloying among Ag, Ni, and Cr and diffusion of Al toward the metal surface are accelerated. the multilayer is composed of a mixture of the forementioned metals. When soldering is carried out, Ag and Ni disappear from the interface and the solder has direct contact with the Cr layer. Even in this case, the adhesion is still secure. After soldering, the Cr layer at the interface contains metals in the multilayer and solder compositions and the Sb-based intermetallic compound is formed at the interface. the adhesion force between the Sn-Sb solder and Cr layer is determined by the diffusion of metals to the Cr layer and the formation of the intermetallic compound.

Published
1994

41. Preparation of O-phosphoryl amino acid building blocks for the synthesis of O-phosphoryl peptides

Author

Ryuichi Saito, Yoshihito Ueno, and Tsujiaki Hata

Subjects
inorganic chemicals, chemistry.chemical_classification, Stereochemistry, Chemistry, Organic Chemistry, macromolecular substances, environment and public health, Biochemistry, Amino acid, Serine, enzymes and coenzymes (carbohydrates), Drug Discovery, bacteria, Organic chemistry, Tyrosine, Threonine
Abstract

Preparation of O-phosphoryl tyrosine, serine, and threonine building blocks for the synthesis of O-phosphoryl peptides is described.

Published
1991

42. Differential Diagnosis of Gastric Adenoma and Type IIA Early Gastric Cancer

Author

Kotaro Fukui, Yoshiya Ogata, Joji Urata, Y. Saito, Akihiko Arakawa, Tadatoshi Tsuchigame, M. Takahashi, M. Sumi, Koki Nakashima, and Ryuichi Saito

Subjects
Adenoma, Adult, Male, medicine.medical_specialty, Pathology, Biopsy, Gastroenterology, 030218 nuclear medicine & medical imaging, Diagnosis, Differential, Lesion, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Internal medicine, Gastroscopy, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Stomach, Cancer, General Medicine, Middle Aged, medicine.disease, digestive system diseases, Endoscopy, Early Gastric Cancer, Radiography, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Differential diagnosis, medicine.symptom, business, Follow-Up Studies
Abstract

The endoscopic and radiographic findings of 45 gastric adenomas in 39 patients were followed for 6 months to 13 years and compared with type IIa early gastric cancer observed in 9 patients. Difficulties in the differential diagnosis of these disorders were evaluated. The following features were suggestive of gastric adenomas: clustered lesions; protuberance with gentle slope; smooth surface; and relatively young patients. Discrimination of adenoma from type IIa early gastric cancer is often difficult by visual observation alone; biopsy was essential in most patients. A group III adenoma verified on biopsy should be followed closely because the lesion may harbor a cancer (so-called carcinoma-in-adenoma) or a cancer may later develop.

Published
1991

43. Synthesis of cytidyl(3'-5')adenosine bearing 2'(3')-O-leucyl ester via a phosphorothioate triester intermediate

Author

Ryuichi Saito, Tsujiaki Hata, Hitoshi Hotoda, and Mitsuo Sekine

Subjects
Ester bond, Ribonucleotide, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, medicine, Cleavage (embryo), Protecting group, Biochemistry, Adenosine, medicine.drug
Abstract

2'(3')-O-(Leucyl)CpA was synthesized in the phosphotriester method. The phenylthio group was used as a protecting group of the Internucleotidic bond. The P-S bond of the triester intermediate was selectively cleaved by using (Bu3Sn)2O under neutral conditions without cleavage of the leucyl ester bond.

Published
1990

44. [Propiverine hydrochloride improved correlatively subjective QOL and objective findings in Japanese patients with urinary frequency and/or incontinence]

Author

Kazumi, Noguchi, Takuya, Yamagishi, Kotaro, Suzuki, Keiichi, Kondo, Takeshi, Kishida, Kazuo, Saito, Yuki, Sekiguchi, Noboru, Nakaigawa, Takehiko, Ogawa, Hiroji, Uemura, Masahiro, Yao, Yoshinobu, Kubota, Masaki, Kawai, Kazuto, Okajima, Kazuki, Kobayashi, Masatoshi, Moriyama, Yuzo, Kinoshita, Kunihisa, Mikata, Kazuo, Kitami, Mitsunobu, Masuda, Ryuichi, Saito, Tetsuo, Murai, Takeshi, Tomoda, Sumio, Noguchi, Naoki, Sakai, Atsushi, Hamano, Sakae, Nomura, and Kazuhiko, Sato

Subjects
Adult, Aged, 80 and over, Male, Parasympatholytics, Middle Aged, Benzilates, Urination Disorders, Drug Administration Schedule, Urinary Incontinence, Surveys and Questionnaires, Quality of Life, Humans, Female, Aged
Abstract

To investigate how urinary frequency and incontinence affect the patient's subjective quality of life (QOL) and whether an improvement in objective findings by medical treatment affects his/her subjective QOL, a voiding diary using the King's Health Questionnaire (KHQ) and International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) was delivered to patients with urinary frequency and/or incontinence before and after treatment with propiverine hydrochloride for 8 weeks. Sixty-eight patients completed the diary and the questionnaires. Objective symptoms decreased significantly with respect to the mean frequency of urination and to the mean incidence of urinary incontinence. The KHQ and ICIQ-SF scores improved significantly with respect to all domains except personal relationships in the KHQ. In the KHQ, furthermore, a significant correlation was found between decreased incidence of urinary incontinence and improvement in role limitations and between decreased incidence of urinary incontinence and improvement in emotional problems. In the ICIQ-SF, a significant correlation was found between decreased incidence of urinary frequency and subjective improvement in quantity of leakage, between decreased incidence of urinary frequency and improvement in subjective QOL scores, between decreased incidence of urinary frequency and improvement in the total ICIQ-SF score, and between decreased incidence of urinary incontinence and improvement in subjective QOL scores. Thirty-two episodes of adverse reactions were observed. None of them were serious. These results suggest that an improvement in objective symptoms with propiverine hydrochloride favorably improves subjective QOL of the patient, and provide further evidence about the safety and efficacy of propiverine hydrochloride.

Published
2006

45. Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan.

Author

Eun-Sil Park, Michio Suzuki, Masanobu Kimura, Hiroshi Mizutani, Ryuichi Saito, Nami Kubota, Youko Hasuike, Jungo Okajima, Hidemi Kasai, Yuko Sato, Noriko Nakajima, Keiji Maruyama, Koichi Imaoka, and Shigeru Morikawa

Subjects
MORBILLIVIRUSES, CAT diseases, TUBULOINTERSTITIAL nephritis & uveitis syndrome, PROTEIN expression, KIDNEY diseases in animals
Abstract

Background: Feline morbillivirus (FmoPV) is a novel paramyxovirus found to infect domestic cats. FmoPV has been isolated in several countries in Asia and Europe and is considered to have genetic diversity. Also, it is suspected to be associated with feline renal diseases including tubulointerstitial nephritis (TIN), which affects domestic cats with a high incidence rate. Results: To clarify the state of FmoPV infection among domestic cats in Japan, an epidemiological survey was conducted. Twenty-one out of 100 cats were found to have serum antibodies (Ab) against FmoPV-N protein by indirect immunofluorescence assay (IF) using FmoPV-N protein-expressing HeLa cells. Twenty-two of the cats were positive for FmoPV RNA in the urine and/or renal tissues. In total, 29 cats were positive for Ab and/or viral RNA. These FmoPV-infected cats were classified into three different phases of infection: RNA+/Ab + (14 cats), RNA+/Ab- (8 cats) and RNA-/Ab + (7 cats). In immunohistochemistry (IHC), 19 out of 29 cats were positive for FmoPV-N protein in kidney tissues; however, the FmoPV-N protein was located in the inflammatory lesions with severe grade in only four out of the 19 cats. Since 15 out of 29 infected cats were positive for viral RNA and Ab, approximately half of the infected cats were persistently infected with FmoPV. Conclusions: A statistically significant difference was observed between infection of FmoPV and the presence of inflammatory changes in renal lesions, indicating a relationship between FmoPV infection and feline renal diseases. However, we could not obtain histopathological evidence of a relationship between FmoPV infection and TIN. [ABSTRACT FROM AUTHOR]

Published
2016
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46. [Clinical evaluation of transcatheter arterial embolization for the management of retroperitoneal bleeding in cases of pelvic fracture]

Author

Takeshi, Sugahara, Ryuichi, Saito, Ryuji, Murakami, and Toshiyuki, Miyazaki

Subjects
Adult, Aged, 80 and over, Male, Accidents, Traffic, Hemorrhage, Middle Aged, Prognosis, Embolization, Therapeutic, Fractures, Bone, Humans, Female, Retroperitoneal Space, Pelvic Bones, Tomography, X-Ray Computed, Aged
Abstract

We evaluated the clinical efficacy of TAE for the management of retroperitoneal bleeding in a case of pelvic fracture.A retrospective review of 206 patients with pelvic fractures was performed. Thirty-four patients who were hemodynamically unstable or had evidence of ongoing hemorrhage required TAE. Rescue rate, effective rate, and mortality rate among the patients with multiple organ injuries were calculated. Charts were reviewed for age, Japanese coma scale (JCS), hemoglobin, blood pressures, extent of retroperitoneal hemorrhage, pelvic fracture pattern/extent of embolization, and time from judging indication of TAE to angiography. Data of patients who died of pelvic fracture hemorrhage was compared with that of others. Statistical analysis was done with analysis of variance, and the two groups were compared using Student's t-test.Rescue rate, success rate, and mortality rate were 76% (26/34), 91% (31/34), and 33% (8/24), respectively. Only JCS reached statistical significance. The complications of gluteal skin and muscle necrosis were experienced in one patient. Two patients with lung contusion and one patient who had suffered from idiopathic interstitial pneumonia died from disseminated intravascular coagulation associated with pneumonia. Viscorectal dysfunctions, which were observed in ten patients, were considered to be independent of TAE.TAE for pelvic fracture hemorrhage was considered effective. Complications of gluteal skin and muscle necrosis should be kept in mind.

Published
2004

47. [Clinical evaluation of esophageal cancer complicated with head and neck cancer]

Author

Tadatoshi, Tsuchigame, Ryuichi, Nishimura, Ichiro, Ogata, Katsuhiko, Mitsuzaki, Joji, Urata, Ryuichi, Saito, Yuji, Baba, Yoshiharu, Nakayama, Masaki, Kadota, Masanori, Imuta, and Yasuyuki, Yamashita

Subjects
Adult, Aged, 80 and over, Male, Neoplasms, Multiple Primary, Esophageal Neoplasms, Head and Neck Neoplasms, Humans, Female, Prospective Studies, Middle Aged, Aged
Abstract

We prospectively investigated endoscopic findings of the upper digestive tract in patients with head and neck (HN) cancer, from 1992 to 2001. Of 687 patients with HN cancer, esophageal cancers were found to affect 74 patients (10.8%). The 74 patients consisted of 49 (66.2%) with the superficial type and 25 (33.8%) with the advanced type. Other additional cancers were detected in 32 cases (4.7%), including 21 gastric cancers. The incidence was highest in patients with hypopharyngeal cancer (32.4%), whereas the incidences in those with oral floor cancer and mesopharyngeal cancer were 14.3% and 13.1%, respectively. The incidence of stage I cancers was lower than that of stage II, III, or IV cancers. Therapy for superficial esophageal cancers consisted of trisection for endoscopic mucosal resection (EMR), surgery, and no treatment. Surgery, radiation therapy, or no treatment was selected in advanced type. For double cancers of HN and esophagus, treatment should be selected in consideration of the prognosis of the disease. These findings suggest that endoscopy with the Lugol-spraying method should be performed in HN cancers for early detection of esophageal cancers.

Published
2003

48. [Clinical evaluation of gastric diverticulum on indirect radiograph for gastric mass survey]

Author

Tadatoshi, Tsuchigame, Ichiro, Ogata, Katsuhiko, Mitsuzaki, Joji, Urata, Akihiko, Arakawa, Ryuichi, Saito, Hideaki, Uozumi, Yasuyuki, Yamashita, Seiji, Tomiguchi, Yukunori, Korogi, and Hiromasa, Bussaka

Subjects
Adult, Aged, 80 and over, Male, Radiography, Diverticulum, Stomach, Humans, Mass Screening, Female, Middle Aged, Aged
Abstract

The aim of this study was to evaluate the clinical conditions of gastric diverticulum. Fifty-four patients with gastric diverticulum (20 men and 34 women among 34,314 patients who underwent medical check-ups) were evaluated on indirect radiographs, for an incidence of 0.16% among the total number of examined cases, a rate lower than that of previous reports. Almost all cases were asymptomatic, had a single diverticulum, and showed a saccular shape. The age distribution indicated higher frequencies in the 5th and 6th decades, and the posterior wall of the fornix was the most common location. Size ranged from 0.6 cm to 12 cm, and 41 cases (75.9%) were between 1.0 cm and 4.0 cm in size. This entity should be kept in mind when reading radiographs of upper gastrointestinal series as well as recognition of pseudodiverticulum and aberrant pancreas as noted for the stomach in several past report. Diverticulum on the cardia, which was previously classified as gastric diverticulum, should be excluded because of the possibility of normal variation.

Published
2003

49. Advanced high current, high reliable IGBT module with improved multi-chip structure

Author

Y. Koike, S. Nonoyama, T. Kushima, H. Shimizu, Ryuichi Saito, and Akira Tanaka

Subjects
Reliability (semiconductor), Materials science, Terminal (electronics), business.industry, Power module, Electrical engineering, Insulated-gate bipolar transistor, Sense (electronics), Heat sink, business, Chip, Common emitter
Abstract

Advanced IGBT module technology to realize high reliability and high current capability was presented. The 60,000 cycles long term power cycle capability of the low thermal expansion base module was demonstrated. A stress release tall mounting structure and a ceramic metal pull back structure were shown to be essential for high thermal cycle capability. A multi-end main terminal with multichip substrate and high resistivity sense emitter terminal technology was applied to realize high current capability and uniformity in the large high power module.

Published
2003

50. Large reverse biased safe operating area for a low loss HiGT

Author

Ryuichi Saito, Yoshihiro Uchino, Hideo Kobayashi, and Mutsuhiro Mori

Subjects
Safe operating area, Materials science, Electrical resistivity and conductivity, business.industry, Electrical engineering, Insulated-gate bipolar transistor, Electric current, business, Short circuit, Line (electrical engineering), Avalanche breakdown, Voltage
Abstract

A high conductivity IGBT (HiGT) with a reverse biased safe operating area (RBSOA) as large as that of a conventional IGBT has been presented. The fabricated HiGT has a rated current of 50 A and a blocking capability of 3.3 kV. Optimizing the concentration of impurities in the hole carrier layer enabled the HiGT to turn off a current twice the rated current by applying 2200 V, which is the maximum voltage of the 1500 V line. This large RBSOA was maintained while achieving a short circuit capability and a better trade-off relation between the collect-emitter saturation voltage (V/sub CE(sat)/) and the turn-off loss. The V/sub CE(sat)/ of this optimized HiGT was 1.3 V lower than that of a conventional IGBT. The turn-off loss, short circuit capability, and static and dynamic avalanche voltages were equivalent to those of a conventional IGBT.

Published
2003

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