1. 948. Improvement of Symptoms of Parkinson's Disease by In Vivo Gene Transfer of Human Hepatocyte Growth Factor - A Model of Gene Therapy for Parkinson's Disease
- Author
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Akihiko Ishida, Naoyuki Sato, Hiromi Koike, Ryuichi Morishida, and Munehisa Shimamura
- Subjects
Pharmacology ,medicine.medical_specialty ,Parkinson's disease ,biology ,Substantia nigra ,Ciliary neurotrophic factor ,medicine.disease ,Endocrinology ,nervous system ,Neurotrophic factors ,Internal medicine ,Drug Discovery ,Genetics ,Cancer research ,medicine ,Vitamin D and neurology ,biology.protein ,Glial cell line-derived neurotrophic factor ,Molecular Medicine ,Hepatocyte growth factor ,Molecular Biology ,medicine.drug ,Neurotrophin - Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra. The ultimate treatment of PD is to repair dopaminergic neurons from degenerative process. As neurotrophic factors have been shown to support the survival and enhance the function of dopaminergic neurons, gene therapy using neurotrophic factors such as glial cell line-derived neurotrophic factor becames center of interests. In the present study, we focused on hepatocyte growth factor (HGF) as a novel neurotrophic and angiogenic growth factor that is a well-known potent pleiotrophic cytokine exhibiting mitogenic, motogenic, and morphogenic activities in a variety of cells.
- Published
- 2005
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