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5. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Author

Aichholzer, Martin, Amorim, Isabel, Aparicio, Javier, Aronica, Eleonora, Arzimanoglou, Alexis, Barba, Carmen, Beck, Jürgen, Becker, Albert, Beckervordersandforth, Jan C, Bien, Christian G, Blümcke, Ingmar, Bodi, Istvan, Braun, Kees PJ, Catenoix, Helene, Chassoux, Francine, Chipaux, Mathilde, Cloppenborg, Thomas, Coras, Roland, Cross, J Helen, De Palma, Luca, De Tisi, Jane, Deleo, Francesco, Devaux, Bertrand, Di Gennaro, Giancarlo, Dorfmüller, Georg, Duncan, John S, Elger, Christian, Ernst, Katharina, Esposito, Vincenzo, Feucht, Martha, Gadze, Zeljka Petelin, Garbelli, Rita, Geleijns, Karin, Gil-Nagel, Antonio, Grote, Alexander, Grunwald, Thomas, Guerrini, Renzo, Hamer, Hajo, Honavar, Mrinalini, Jacques, Thomas S, Jakovcevic, Antonia, Jutila, Leena, Kalina, Adam, Kälviäinen, Reetta, Klein, Karl Martin, Koenig, Kristina, Krsek, Pavel, Kudernatsch, Manfred, Kudr, Martin, Lamberink, Herm J, Malmgren, Kristina, Marusic, Petr, Melikyan, Armen, Menzler, Katja, Noachtar, Soheyl, Otte, Willem M, Özkara, Çiğdem, Pieper, Tom, Pimentel, Jose, Raicevic, Savo, Rheims, Sylvain, Ribeiro, Joana, Rosenow, Felix, Rössler, Karl, Rydenhag, Bertil, Sales, Francisco, San Antonio-Arce, Victoria, Schaller, Karl Lothar, Schijns, Olaf, Scholl, Theresa, Schramm, Johannes, Schulze-Bonhage, Andreas, Sciot, Raf, Seeck, Margitta, Shishkina, Lyudmila, Sokic, Dragoslav, Specchio, Nicola, Theys, Tom, Thom, Maria, Delgado, Rafael Toledano, Toulouse, Joseph, Uzan, Mustafa, van Loon, Johannes, Van Paesschen, Wim, von Oertzen, Tim J, Jansen, Floor, Leijten, Frans, van Rijen, Peter, Spliet, Wim GM, Mühlebner, Angelika, Kasper, Burkhard S, Fauser, Susanne, Polster, Tilman, Kalbhenn, Thilo, Delev, Daniel, McEvoy, Andrew, Miserocchi, Anna, Landré, Elisabeth, Turak, Bares, Varlet, Pascale, Ferrand-Sorbets, Sarah, Fohlen, Martine, Bulteau, Christine, Edelvik, Anna, Shah, Mukesch J, Scheiwe, Christian, Delicado, Eva Gutierrez, Tisdall, Martin, Eltze, Christin, Akkol, Serdar, Deniz, Kaancan, Oz, Buge, Holthausen, Hans, Hartlieb, Till, Staudt, Martin, Casciato, Sara, Quarato, Pier P, Giangaspero, Felice, Streichenberger, Nathalie, Guenot, Marc, Isnard, Jean, Valentijn, Antonio, Chang, Amanda, Mullatti, Nandini, Zamecnik, Josef, Zarubova, Jana, Tomasek, Martin, Immonen, Arto, Saarela, Anni, Rauramaa, Tuomas, Lobrinus, Johannes A, Egervari, Kristof, Momjian, Shahan, Harti, Elisabeth, Lohr, Hannah, Kroell, Judith, Vermeulen, Lynn, Cleeren, Evy, Vlasov, Pavel, Kozlova, Antonia, Vorobyev, Alexey, Goeppel, Gudrun, Samueli, Sharon, Czech, Thomas, Hainfellner, Johannes, Puttinger, Gertraud, Schwarz, Gabriele, Stefanits, Harald, Weis, Serge, Spreafico, Roberto, Villani, Flavio, Rossini, Laura, Hermsen, Anke, Knake, Susanne, Nimsky, Christopher, Carl, Barbara, Belohlavkova, Anezka, Benova, Barbora, Bisschop, Jeroen, Colon, Albert, van Kranen-Mastenbroek, Vivianne, Rouhl, Rob PW, Hoogland, Govert, Rumiá, Jordi, Ramírez-Camacho, Alia, Candela-Cantó, Santiago, Ostrowsky-Coste, Karine, Panagiotakaki, Eleni, Montavont, Alexandra, Kosal, Pascale Keo, Gokce-Samar, Zeynep, Milleret, Clara, Buccoliero, Anna M, Giordano, Flavio, Sulentic, Vlatko, Mrak, Goran, Desnica, Andrej, CarfíPavia, Giusy, De Benedictis, Alessandro, Marras, Carlo E, Bascarevic, Vladimir, Vojvodic, Nikola, Ristic, Aleksandar, Rebelo, Olinda, Aledo-Serrano, Angel, Garcia-Morales, Irene, Anciones, Carla, and Braun, Kees P J

Published
2020
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7. Grading system for assessing the confidence in the epileptogenic zone reported in published studies: A Delphi consensus study

Author

Ryvlin, Philippe, primary, Barba, Carmen, additional, Bartolomei, Fabrice, additional, Baumgartner, Christoph, additional, Brazdil, Milan, additional, Fabo, Daniel, additional, Fahoum, Firas, additional, Frauscher, Birgit, additional, Ikeda, Akio, additional, Lhatoo, Samden, additional, Mani, Jayanti, additional, McGonigal, Aileen, additional, Metsahonkala, Eeva‐Liisa, additional, Mindruta, Ioana, additional, Nguyen, Dang Khoa, additional, Rheims, Sylvain, additional, Rocamora, Rodrigo, additional, Rydenhag, Bertil, additional, Schuele, Stephan, additional, Schulze‐Bonhage, Andreas, additional, Surges, Rainer, additional, Vulliemoz, Serge, additional, and Beniczky, Sandor, additional

Published
2024
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11. Surgical resection of cavernous angioma located within eloquent brain areas: International survey of the practical management among 19 specialized centers

Author

Zanello, Marc, Meyer, Bernhard, Still, Megan, Goodden, John R., Colle, Henry, Schichor, Christian, Bello, Lorenzo, Wager, Michel, Smits, Anja, Rydenhag, Bertil, Tate, Matthew, Metellus, Philippe, Hamer, Philip De Witt, Spena, Giannantonio, Capelle, Laurent, Mandonnet, Emmanuel, Robles, Santiago Gil, Sarubbo, Silvio, Martino González, Juan, Fontaine, Denys, Reyns, Nicolas, Krieg, Sandro M., Huberfeld, Gilles, Wostrack, Maria, Colle, David, Robert, Erik, Noens, Bonny, Muller, Peter, Yusupov, Natan, Rossi, Marco, Conti Nibali, Marco, Papagno, Costanza, Visser, Victoria, Baaijen, Hans, Galbarritu, Lara, Chioffi, Franco, Bucheli, Carlos, Roux, Alexandre, Dezamis, Edouard, Duffau, Hugues, and Pallud, Johan

Published
2019
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24. European trends in epilepsy surgery

Author

Baud, Maxime O., Perneger, Thomas, Rácz, Attila, Pensel, Max C., Elger, Christian, Rydenhag, Bertil, Malmgren, Kristina, Cross, J. Helen, McKenna, Grainne, Tisdall, Martin, Lamberink, Herm J., Rheims, Sylvain, Ryvlin, Philippe, Isnard, Jean, Mauguière, François, Arzimanoglou, Alexis, Akkol, Serdar, Deniz, Kaancan, Ozkara, Cigdem, Lossius, Morten, Rektor, Ivan, Kälviäinen, Reetta, Vanhatalo, Lotta-Maria, Dimova, Petia, Minkin, Krassimir, Staack, Anke Maren, Steinhoff, Bernhard J., Kalina, Adam, Krsek, Pavel, Marusic, Petr, Jordan, Zsofia, Fabo, Daniel, Carrette, Evelien, Boon, Paul, Rocka, Saulius, Mameniškienė, Rūta, Vulliemoz, Serge, Pittau, Francesca, Braun, Kees P.J., and Seeck, Margitta

Published
2018
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29. Timing of referral to evaluate for epilepsy surgery: Expert Consensus Recommendations from the Surgical Therapies Commission of the International League Against Epilepsy

Author

Jehi, Lara, primary, Jette, Nathalie, additional, Kwon, Churl‐Su, additional, Josephson, Colin B., additional, Burneo, Jorge G., additional, Cendes, Fernando, additional, Sperling, Michael R., additional, Baxendale, Sallie, additional, Busch, Robyn M., additional, Triki, Chahnez Charfi, additional, Cross, J. Helen, additional, Ekstein, Dana, additional, Englot, Dario J., additional, Luan, Guoming, additional, Palmini, Andre, additional, Rios, Loreto, additional, Wang, Xiongfei, additional, Roessler, Karl, additional, Rydenhag, Bertil, additional, Ramantani, Georgia, additional, Schuele, Stephan, additional, Wilmshurst, Jo M., additional, Wilson, Sarah, additional, and Wiebe, Samuel, additional

Published
2022
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31. Quality of life in patients with glioblastoma and their relatives

Author

Stahl, Pernilla, Henoch, Ingela, Smits, Anja, Rydenhag, Bertil, Ozanne, Anneli, Stahl, Pernilla, Henoch, Ingela, Smits, Anja, Rydenhag, Bertil, and Ozanne, Anneli

Abstract

Objectives Glioblastoma is the most aggressive primary brain tumour in adults. The rapid decline of physical and cognitive functions is likely to affect patients and relatives during the entire course of disease. The aim of this study was to describe and compare (a) health-related quality of life (HRQoL) and psychological symptoms between patients with glioblastoma and their relatives, and (b) HRQoL between patients and a general population over time. Methods At baseline, 63 patients and 63 relatives were included. The participants completed the Short Form Health Survey (SF-36) and the Hospital Anxiety and Depression scale (HADS) at seven different occasions from pre-surgery until two years post-surgery. A comparison of SF-36 was made between patients and an age- and gender-matched control group. Descriptive analysis, effect size and Wilcoxon signed-rank test were used. Results Relatives scored lower health-related quality of life (HRQoL) and higher symptoms of anxiety than patients, whilst patients scored worse in the physical parts of the SF-36. Three weeks post-surgery, relatives scored their lowest HRQoL and had the highest risk of anxiety symptoms. Comparing patients with controls, the patients rated worse in both the mental and physical component summaries in HRQoL at most time points. Conclusion Both patients and relatives showed deterioration of HRQoL. In addition, relatives showed high frequency of anxiety symptoms. Our data reveal that relatives of patients with glioblastoma need attention throughout the disease trajectory and they also need support at the right time point.

Published
2022
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35. Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe

Author

Mouthaan, Brian E., Rados, Matea, Barsi, Péter, Boon, Paul, Carmichael, David W., Carrette, Evelien, Craiu, Dana, Cross, Helen J., Diehl, Beate, Dimova, Petia, Fabo, Daniel, Francione, Stefano, Gaskin, Vladislav, Gil-Nagel, Antonio, Grigoreva, Elena, Guekht, Alla, Hirsch, Edouard, Hecimovic, Hrvoje, Helmstaedter, Christoph, Jung, Julien, Kalviainen, Reetta, Kelemen, Anna, Kimiskidis, Vasilios, Kobulashvili, Teia, Krsek, Pavel, Kuchukhidze, Giorgi, Larsson, Pål G., Leitinger, Markus, Lossius, Morten I., Luzin, Roman, Malmgren, Kristina, Mameniskiene, Ruta, Marusic, Petr, Metin, Baris, Özkara, Cigdem, Pecina, Hrvoje, Quesada, Carlos M., Rugg-Gunn, Fergus, Rydenhag, Bertil, Ryvlin, Philippe, Scholly, Julia, Seeck, Margitta, Staack, Anke M., Steinhoff, Bernhard J., Stepanov, Valentin, Tarta-Arsene, Oana, Trinka, Eugen, Uzan, Mustafa, Vogt, Viola L., Vos, Sjoerd B., Vulliémoz, Serge, Huiskamp, Geertjan, Leijten, Frans S. S., Van Eijsden, Pieter, and Braun, Kees P. J.

Published
2016
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41. A randomized phase II trial of efficacy and safety of the immunotherapy ALECSAT as an adjunct to radiotherapy and temozolomide for newly diagnosed glioblastoma.

Author

Werlenius, Katja, Stragliotto, Giuseppe, Strandeus, Michael, Blomstrand, Malin, Carén, Helena, Jakola, Asgeir S, Rydenhag, Bertil, Dyregaard, Dorte, Dzhandzhugazyan, Karine N, Kirkin, Alexei F, Raida, Martin K, Smits, Anja, Kinhult, Sara, Werlenius, Katja, Stragliotto, Giuseppe, Strandeus, Michael, Blomstrand, Malin, Carén, Helena, Jakola, Asgeir S, Rydenhag, Bertil, Dyregaard, Dorte, Dzhandzhugazyan, Karine N, Kirkin, Alexei F, Raida, Martin K, Smits, Anja, and Kinhult, Sara

Abstract

Background: There is an urgent need for effective treatments against glioblastoma (GBM). In this trial, we investigated the efficacy and safety of an adoptive cell-based immunotherapy. Methods: Patients with newly diagnosed GBM were recruited at 4 study sites in Sweden. The patients were randomized 1:2 to receive either radiotherapy (RT), 60 Gy/30 fractions, with concomitant and adjuvant temozolomide (TMZ) only, or RT and TMZ with the addition of Autologous Lymphoid Effector Cells Specific Against Tumor (ALECSAT) in an open-label phase II trial. The primary endpoint was investigator-assessed progression-free survival (PFS). The secondary endpoints were survival and safety of ALECSAT. Results: Sixty-two patients were randomized to either standard of care (SOC) with RT and TMZ alone (n = 22) or SOC with ALECSAT (n = 40). Median age was 57 years (range 38-69), 95% of the patients were in good performance status (WHO 0-1). There was no significant difference between the study arms (SOC vs ALECSAT + SOC) in PFS (7.9 vs 7.8 months; hazard ratio [HR] 1.28; 95% confidence interval [CI] 0.70-2.36; P = .42) or in median overall survival (OS) (18.3 vs 19.2 months; HR 1.16, 95% CI 0.58-2.31; P = .67). The treatment groups were balanced in terms of serious adverse events (52.4% vs 52.5%), but adverse events ≥grade 3 were more common in the experimental arm (81.0% vs 92.5%). Conclusion: Addition of ALECSAT immunotherapy to standard treatment with radiochemotherapy was well tolerated but did not improve PFS or OS for patients with newly diagnosed GBM.

Published
2021
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48. Patterns of care and clinical outcome in assumed glioblastoma without tissue diagnosis : A population-based study of 131 consecutive patients

Author

Werlenius, Katja, Fekete, Boglarka, Blomstrand, Malin, Caren, Helena, Jakola, Asgeir S., Rydenhag, Bertil, Smits, Anja, Werlenius, Katja, Fekete, Boglarka, Blomstrand, Malin, Caren, Helena, Jakola, Asgeir S., Rydenhag, Bertil, and Smits, Anja

Abstract

Background Elderly patients with glioblastoma and an accumulation of negative prognostic factors have an extremely short survival. There is no consensus on the clinical management of these patients and many may escape histologically verified diagnosis. The primary aim of this study was to characterize this particular subgroup of patients with radiological glioblastoma diagnosis without histological verification. The secondary aim was to evaluate if oncological therapy was of benefit. Methods Between November 2012 and June 2016, all consecutive patients presenting with a suspected glioblastoma in the western region of Sweden were registered in a population-based study. Of the 378 patients, 131 (35%) met the inclusion criteria of the present study by typical radiological features of glioblastoma without histological verification. Results The clinical characteristics of the 131 patients (72 men, 59 women) were: age ≥ 75 (n = 99, 76%), performance status according to Eastern Cooperative Oncology Group ≥ 2 (n = 93, 71%), significant comorbidity (n = 65, 50%) and multilobular tumors (n = 90, 69%). The overall median survival rate was 3.6 months. A subgroup of 44 patients (34%) received upfront treatment with temozolomide, with an overall radiological response rate of 34% and a median survival of 6.8 months, compared to 2.7 months for those receiving best supportive care only. Good performance status and temozolomide treatment were statistically significant favorable prognostic factors, while younger age was not. Conclusion Thirty-five percent of patients with a radiological diagnosis of glioblastoma in our region lacked histological diagnosis. Apart from high age and poor performance status, they had more severe comorbidities and extensive tumor spread. Even for this poor prognostic group upfront treatment with temozolomide was shown of benefit in a subgroup of patients. Our data illustrate the need of non-invasive diagnostic methods to guide optimal individualized therap

Published
2020
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49. Short-term outcome following surgery for rare brain tumor entities in adults : a Swedish nation-wide registry-based study and comparison with SEER database

Author

Bartek Jr., Jiri, Dhawan, Sanjay, Thurin, Erik, Alattar, Ali, Gulati, Sasha, Rydenhag, Bertil, Henriksson, Roger, Chen, Clark C., Jakola, Asgeir Store, Bartek Jr., Jiri, Dhawan, Sanjay, Thurin, Erik, Alattar, Ali, Gulati, Sasha, Rydenhag, Bertil, Henriksson, Roger, Chen, Clark C., and Jakola, Asgeir Store

Abstract

Objective: To investigate outcomes after surgery for rare brain tumors using the Swedish Brain Tumor Registry (SBTR). Methods: This is a nationwide study of patient in the SBTR, validated in the Surveillance, Epidemiology, and End Results (SEER) registries. We included all adults diagnosed 2009-2015 with a rare brain tumor entity (n = 216), defined as ependymoma (EP, n = 64), subependymoma (SUBEP, n = 21), ganglioglioma (GGL, n = 54), pilocytic astrocytoma (PA, n = 56) and primitive neuroectodermal tumor (PNET, n = 21). We analyzed symptomatology, tumor characteristics and outcomes. Results: Mean age was 38.3 +/- 17.2 years in GGL, 36.2 +/- 16.9 in PA, 37.0 +/- 19.1 in PNET, 51.7 +/- 16.3 in EP and 49.8 +/- 14.3 in SUBEP. The most common symptom was focal deficit (39.6-71.4%), and this symptom was most common in GGL patients with 64.2% of GGL presenting with seizures. Most patients had no or little restriction in activity before surgery (Performance Status 0-1), although up to 15.0% of PNET patients had a performance status of 4. Gross total resection was achieved in most (> 50%) tumor categories. Incidence of new deficits was 11.1-34.4%. In terms of postoperative complications, 0-4.8% had a hematoma of any kind, 1.9-15.6% an infection, 0-7.8% a venous thromboembolism and 3.7-10.9% experienced a complication requiring reoperation. There were 3 deaths within 30-days of surgery, and a 1-year mortality of 0-14.3%. Conclusion: We have provided benchmarks for the current symptomatology, tumor characteristics and outcomes after surgery for rare brain tumors as collected by the SBTR and validated our results in an independent registry. These results may aid in clinical decision making and advising patients.

Published
2020
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50. Pre-traumatic conditions can influence cortisol levels before and after a brain injury

Author

Sorbo, Ann, Eiving, Ingrid, Theodorsson, Elvar, Rydenhag, Bertil, Jonsdottir, Ingibjorg H., Sorbo, Ann, Eiving, Ingrid, Theodorsson, Elvar, Rydenhag, Bertil, and Jonsdottir, Ingibjorg H.

Abstract

Objective Satisfactory anabolic reactions, including the activation of the hypothalamic-pituitary-adrenal (HPA) axis, are essential following severe traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH). Many factors may influence this activation. This study aimed to investigate whether individuals who reported chronic diseases, psychosocial afflictions, or stressful events before a severe brain injury display a different pattern regarding cortisol levels retrospectively and up to three months compared with those who did not report stressful experiences. Materials and Methods Fifty-five patients aged 16-68 years who were admitted to the neurointensive care unit (NICU) were included. Hair cortisol measurements offer a unique opportunity to monitor cortisol levels retrospectively and after the trauma. Hair strands were collected as soon as possible after admission to the NICU and every month until three months after the injury/insult. The participants/relatives were asked about stressful events, psychosocial afflictions and recent and chronic diseases. Results The group who reported chronic diseases and/or stressful events before the brain injury had more than twice as high median hair cortisol levels before the brain injury compared with those who did not report stress, but the difference was not statistically significant (P = .12). Those who reported stress before the brain injury had statistically significantly lower hair cortisol values after the brain injury and they remained until three months after the injury. Conclusions Stressful events and/or chronic disease before brain injury might affect mobilization of adequate stress reactions following the trauma. However, the large variability in cortisol levels in these patients does not allow firm conclusions and more studies are needed., Funding Agencies|Health and Medical Care Committee of Region Vastra Gotaland; Department of Research and Development-NU Hospital Organization, Region Vastra Gotaland; Department of Research Sodra Alvsborg Hospital; Sodra Alvsborg Research Council, Region Vastra Gotaland, Sweden

Published
2020
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