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This article considers further development of the mathematical model that allows predicting the socio-economic situation and choosing the optimal management strategy in conditions of a mass disease. The model is a dynamic optimal control problem with a delay in phase variables. It takes into account social, biological and economic factors. The proposed modification of the model consists in simultaneous use of several quality criteria for evaluating management strategies, for which two approaches are proposed. The first approach is based on the reduction of criteria to same unit of measurement, which is the value of a statistical life. The second one consists of normalization of the criteria. Computational experiments were carried out using both modifications of the model; in particular, for the second approach, a series of calculations with different combinations of criteria significance was performed. The experiments used the values of the model parameters estimated on the basis of statistical data on the COVID-19 pandemic in the Russian Federation and the Ulyanovsk region. A modification of the numerical parameterization method developed by the authors was used to find a solution. The optimal solutions obtained for the Russian Federation and the Ulyanovsk region do not coincide when using the same objective functional. Such a result may indicate that it is desirable to choose a specific management strategy for each region.

Published in 2021, both monographs on Tennessee Williams — Stanley Gontarski’s Tennessee Williams, T-shirt Modernism and the Refashionings of Theater and Laura Michiels’ The Metatheater of Tennessee Williams: Tracing the Artistic Process Through Seven Plays perform the dual task of offering new perspectives on the playwright’s wellstudied plays and elaborating on the lesser-known material with its non-obvious cultural functions. Researchers show the complexity of Williams’ late oeuvre, demonstrating how his plays of the 1960s and early 1980s continue theatrical experiments of the second half of the 20th century. Developing the themes of his earlier period (theatricality of life and experience, the vulnerability of beauty and artistry, the fragility of memory, and the conflicts between the strong and the weak), Williams has enriched both poetic and naturalistic theater styles through absurdist aesthetics, his use of stylistic excess and an emphasis on metatheatre — spectacles about spectacles. Gontarski's book discusses Williams' influence on subsequent popular culture and its representation of the images of masculinity. Gontarski shows how Williams' success across the Atlantic depended on censorship (“The Lord Chamberlain’s Blue Pencil” being an intriguing part of Chapter 2) or greater stage freedom (Sweden). Late plays (In the Bar of a Tokyo Hotel, Two-Character Play, Clothes for a Summer Hotel) allow the author to take a closer look at Williams’ absurdist poetics and the intriguing process of “becoming Beckett,” which the American playwright reenacts. Laura Michiels explores different types of metatheater in Williams’s work: “mythical” (Orpheus Descending), “esoteric” (Two-Character Play), “marauding” (Clothes for the Summer Hotel), “multiplying" and “negotiating” (Sweet Bird of Youth, Something Cloudy, Something Clear). Michiels shows how Williams' dramas open up to issues important for contemporary interdisciplinary studies: the audience’s emotional and affective responsiveness, the work of memory, and intermedial dialogism. Michiels’ book offers a wide range of tools for unpacking metatheatricality of the 20th-century drama.

Mentoring in higher education is a necessity and an obligatory process of transferring the experience of teaching staff to young teachers. Statistics show that the younger generation is not eager to devote themselves to teaching, sometimes because they are not aware of all aspects of the profession. The mentoring task in higher education is to involve the younger generation in a unique pedagogical process. The work is complex, requiring from the parties a creative approach and the ability to turn a young specialist in the direction of pedagogy. Everything is important in this process from understanding the financial component to recognizing the social significance of the activity. Mentoring for young teachers, graduate students, masters in teaching economic disciplines, along with the regularities of the process has its own significant features, which arise from the economic reality study specifics, as well as the presence of numerous concepts and theories that interpret this economic reality itself and on the basis of this proposing a certain state economic policy. The issue becomes relevant also because the approaches to the federal state educational standards are being transformed in Russia.

This research explores the environmentally friendly consumer behavior of Millennials in Kazakhstan through a quantitative approach. The study targets the pressing issue of sustainable consumption practices among this generation, which holds significant implications for environmental conservation. This study is aimed at exploration of determinants, patterns, and motivations behind environmentally friendly consumer behavior among Millennials in Kazakhstan. It seeks to identify the main factors influencing their choices, the extent to which eco-consciousness guides their decisions, and the influence of external factors, such as marketing strategies and peer influence. This research holds both scientific and practical significance contributing to the existing literature and offering insights into the emerging trends of green consumerism among Millennials in a Central Asian context. Moreover, it provides a quantitative assessment of the factors shaping their eco-friendly consumption, allowing for a nuanced understanding of their behavior. The research methodology involves the administration of structured surveys to a representative sample of Millennials in Kazakhstan. Data analysis performed with the use of such statistical methods as regression analysis and hypothesis testing to draw meaningful conclusions. Preliminary findings suggest that while environmental awareness plays a role in Millennials' consumer choices, other factors such as affordability and convenience also significantly influence their behavior. The research underscores the need for targeted strategies to encourage more sustainable consumption practices among this demographic. In conclusion, this research contributes valuable insights into the environmentally friendly consumer behavior of millennials in Kazakhstan, shedding light on the factors driving their choices and serving as a basis for the development and implementation of effective sustainability campaigns. It has the potential to inform policymakers, marketers, and businesses seeking to align their strategies with the preferences of this eco-conscious generation. Key words: millennials, environmentally friendly consumer behavior, Kazakhstan, sustainability.

Background. Anemia represents one of the most frequent complications in inflammatory bowel disease and severely impairs the quality of life of affected patients. The etiology of anemia in inflammatory bowel disease patients can be multifactorial, often involving a combination of iron deficiency anemia and anemia of chronic disease. The choice of therapy, focused on the leading cause of anemia, allows for individualized therapy, minimizing the risk of side effects and the cost of therapy.Aim. A comparative analysis of blood parameters before and after treatment was performed.Materials and methods. For 5 years, 47 patients (15 women, 32 men) with inflammatory bowel disease with a median age of 48 years (from 28 to 65 years) were studied. Two groups were formed: patients with iron deficiency anemia and patients with anemia of chronic disease. Patients with combination of iron deficiency anemia and anemia of chronic disease D (n = 21) were not included. A division was also made according to the type of treatment performed.Results. In the iron deficiency anemia group, a statistically significant increase in hemoglobin level was revealed as a result of the use of intravenous iron. During therapy with oral iron and B vitamin therapy, as well as therapy aimed only at correcting gastrointestinal tract pathology, no reliable dynamics of the studied parameters was observed. In the anemia of chronic disease group, there were no significant changes in red blood cell parameters with any of the treatment options (p >0.05).Conclusion. The effectiveness of various therapeutic approaches to correct anemia is controversial. Further follow-up and an increase in the sample size are needed, which will help individualize therapy and improve the patients’ quality of life.

Abstract CsqR (YihW) is a local transcription factor that controls expression of yih genes involved in degradation of sulfoquinovose in Escherichia coli. We recently showed that expression of the respective gene cassette might be regulated by lactose. Here, we explore the phylogenetic and functional traits of CsqR. Phylogenetic analysis revealed that CsqR had a conserved Met25. Western blot demonstrated that CsqR was synthesized in the bacterial cell as two protein forms, 28.5 (CsqR-l) and 26 kDa (CsqR-s), the latter corresponding to start of translation at Met25. CsqR-s was dramatically activated during growth with sulfoquinovose as a sole carbon source, and displaced CsqR-l in the stationary phase during growth on rich medium. Molecular dynamic simulations revealed two possible states of the CsqR-s structure, with the interdomain linker being represented by either a disordered loop or an ɑ-helix. This helix allowed the hinge-like motion of the N-terminal domain resulting in a switch of CsqR-s between two conformational states, “open” and “compact”. We then modeled the interaction of both CsqR forms with putative effectors sulfoquinovose, sulforhamnose, sulfoquinovosyl glycerol, and lactose, and revealed that they all preferred the same pocket in CsqR-l, while in CsqR-s there were two possible options dependent on the linker structure.

Russian aggression adversely affected the economy of Ukraine and emphasized the need to adapt the best practices of EU countries to determine steps to restore the country’s competitiveness. This study aims to determine the influence of the innovative development of countries on their competitiveness and identify prospects for Ukraine’s post-war economic recovery. The study constructed neural networks to assess the relationships between the factors of innovative development and the competitiveness of the EU countries and Ukraine. Six main factors of innovative development of countries are identified: “innovations in business (S1),” “intellectual property (S2)”, “innovations in industry (S3),” “eco-innovations (S4),” “innovation management (S5),” and “digital innovations (S5).” Groups of factors are determined by the strength of influence (strong, moderate, or weak). For Ukraine, S1 and S6 have a strong effect (33.3%), S5 shows moderate (16.7%), S2, S3, and S4 show weak effects (50%). For EU countries, S1 and S6 have a strong influence, S2 and S3 – moderate, S5 and S4 – weak. This comparative analysis concluded that EU countries consider intellectual property, green economy, and state innovation policy as key components of their competitiveness. The results discovered a weak relationship between intellectual property protection, innovation in industry, and competitiveness of Ukraine compared to EU countries. However, digital innovations significantly and positively affect Ukraine’s competitiveness.

The research deals with estimating the potential of Russian enterprises of tube industry and possibilities of their efficient adaptation to fast changes. Academic results of the research include systematization, summarizing and author’s appraisal of processes taking place in Russian tube industry, as well as proposals aimed at its development. According to the research, Russian tube industry rather quickly adapts to changes and is still stable in spite of difficult situation and high sectoral risks. Today the potential of the increase in home demand for tubes is not realized in full, especially for products with high added value. Tube industry is facing the problem of importsubstitution in equipment purchase and production modernization. To resolve it a set of measures is necessary, such as starting the mechanism of innovation development in machine-building manufacturing; working-out the program of developing home industry of electronics, software, systems of management and engineering; motivating the growth in production capacities of machine-building enterprises. It is necessary to raise investment from countries importing tube products in Asia, Africa and Middle East. These regions can become both the marketing targets and sources of investment. In conditions of instability tube industry is strategically important for the country and needs measures of state support.

The paper continues the research of R. Kronover and J. Minlor, H.-O. Peitgen and P. H. Richter. Using mathematical methods and computer experiments, the first- and second-order framings of the Mandelbrot sets of three families of the quadratic polynomials of a complex variable are revealed. The connection between the first-and second-order framings of Mandelbrot sets of the functions [f.sub.2](z) = [z.sup.2] + cz, [f.sub.3](z) = [z.sup.2] + z + c, and [f.sub.4](z) = c[z.sup.2] + c with remarkable curves (cardioid, lemniscate, and circle) was established. The algorithms of constructing the framings of Mandelbrot sets of considered functions in the mathematical package MathCad and Pascal programs have been worked out. Algorithms for constructing Mandelbrot sets in Pascal programs are developed., Mandelbrot sets are very complex mathematical objects, which are currently intensively studied and applied [1,2,4-17]. Following [2], by the Mandelbrot set of the quadratic polynomial we will mean the set [...]

Objectives. To investigate the regularities of the process of joint production of epoxycyclohexane, cyclohexanol, and cyclohexanone using the cyclohexene epoxidation reaction with cyclohexyl hydroperoxide in the presence of an ammonium paramolybdate catalyst, representing an alternative to the method of cyclohexanol and cyclohexanone synthesis by alkaline catalytic decomposition of cyclohexyl hydroperoxide.Methods. The qualitative and quantitative analysis of the obtained intermediate and target compounds was determined using modern physicochemical research methods: gas–liquid chromatography using the Chromatec-Crystal 5000.2 hardware and software complex with a flame ionization detector and infrared spectroscopy on an RX-1 infrared Fourier spectrometer. The content of hydroperoxide in the oxidation products was determined using iodometric titration, while the carboxylic acid content was determined by the titrimetric method based on the neutralization reaction.Results. The presented method for obtaining cyclohexanol and cyclohexanone together with epoxycyclohexane by the reaction of cyclohexene epoxidation with cyclohexyl hydroperoxide containing cyclohexane in the products of high-temperature liquid-phase oxidation is experimentally substantiated. The influence of various technological parameters on the process of liquid-phase oxidation of cyclohexane to hydroperoxide is described. The conditions for carrying out this reaction are determined to ensure the achievement of a content of cyclohexyl hydroperoxide of 1.5 wt % in the products of oxidation. The regularities of the epoxidation reaction of the synthesized cyclohexyl hydroperoxide with cyclohexene in the presence of an ammonium paramolybdate catalyst are analyzed.Conclusions. Epoxidation of cyclohexene with cyclohexyl hydroperoxide produced epoxycyclohexane at a yield of 80–90% and a conversion of cyclohexane hydroperoxide of 85%.

Currently, adsorption gas sensors are of great interest for environmental monitoring. The approaches to improving their properties include synthesis of nanostructured materials of various shapes and modification of the metal oxide chemical composition. The aim of this work is to develop ways to improve the sensor properties of zinc oxide nanowires by changing the surface structure during processing in solutions of tin and iron compounds, as well as adding special precursors during their synthesis. The layers consisting of zinc oxide nanowires were produced by hydrothermal method. Ternary Zn-Sn-O and Zn-Fe-O nanosystems were synthesized as a result of processing of zinc oxide nanowires in solutions containing potassium stannate and iron sulfate, respectively. ZnO nanowires were also synthesized in a solution containing sodium bromide in addition to the general precursors. The surface chemical composition was analyzed using X-ray photoelectron spectroscopy. Sensor properties were investigated by detecting acetone, isopropanol and methanol vapors. It was shown that the sensor response of the produced samples exceeds the response of the initial zinc oxide nanowires. The samples of Zn-Sn-O ternary oxide system have the best response. The improvement of the sensor response may be associated with an increase in the content of adsorbed oxygen ions on the surface of the samples, the presence of metal cations with different properties as well as the formation of heterostructures.

Peter Kunze’s book Staging a Comeback: Broadway, Hollywood, and the Disney Renaissance is a (overwhelmingly) well-researched study of the transmedial migration of popular narratives in the 1980s and the 1990s. Focused on Disney’s appropriation of the Broadway integrated musical (H. Ashman, A. Menken), the study demonstrates how the musical theatre conventions improved the quality of Disney’s main product — the animated film. Kunze engages in close reading of an extended episode from the history of cultural production (the Disney Renaissance), showing the complexity and unpredictability of various media convergences. For instance, the book reconfigures the roles of managerial and creative labourers behind the Disney transformation, wittily (and convincingly) bringing to the forefront 1982 as annus mirabilis, which triggered immense changes in the cultural sector. After discussing Disney's appropriation of the musical Broadway, the book reveals how the updated animated musical comes back to the theatrical stage and transforms ‘respectable’ Broadway by alternative styles and agendas (Julie Taymor’s The Lion King). Apart from other sources, the research uses hardto- access archival materials, the author's interviews with the practitioners and their entourage.

Neither Jane Austen’s writing, nor film adaptations of her novels made in the heritage film tradition seem particularly uncanny. Linked in the viewers’ minds with the representation of the English countryside stability, the films promote traditional values and take the spectators away from the problems and anxieties of the contemporary status quo. However, Patricia Rozema’s Mansfield Park (1999) uses Austen’s plot to question the colonial past by creating uncanny effects. Understood in this paper as an eerie resurfacing of the hidden (following Friedrich Wilhelm Joseph Schelling, Sigmund Freud, John Hodgkins, Barbara Creed), the uncanny becomes a tool for inquiring into how contemporary filmmakers and their audiences revisit old stories. Rozema creates two subplots for the main narrative: a story about an artist’s growth (Fanny Price becomes a writer) and a colonial narrative, which foregrounds the Bertrams’ dependence on their property in Antigua and their use of slave labour. Both plot lines enrich the film with uncanny effects linked to the inherent intermediality of film adaptations. Grotesquely frightening verbal images from Fanny’s writing (extracts from Austen’s Juvenilia) and the uncanny visuality of Tom Bertram’s drawings frame the viewer’s revisitation of Mansfield Park while reminding him/her of a subversive potential – of the uncanny and film adaptations.

Purpose. To assess the ecological condition of the Sumy region's soils and to develop priority directions for the protection of land resources of any form of ownership. Methods. The theoretical method of system analysis, comparison and generalization were used in the framework of the conducted research. Current legal acts and research by scientists on land use problems served as the theoretical basis. Statistical data on the state of land resources of the Sumy region served as an information base for the analysis and comparison of phenomena. Results. The ecological condition of the agricultural lands of the Sumy region was analyzed. Weaknesses in the existing soil protection system of the region were identified. Modern land use in most cases is not rational. Excessive plowing of agricultural land leads to depletion of land resources, depression of rural areas, disruption of the natural process of soil formation. Measures to improve and preserve the land cover and its rational use in the Sumy region are proposed. The use of analytical studies allows to thoroughly characterize the economic potential of agricultural lands of the Sumy region, to determine the prospects for their use, reproduction and increase in fertility, which corresponds to the interests of the state, territorial communities, their population and economic entities on the land. The land reform, which is being carried out in Ukraine, sets itself the main task of opening a free land market, is a nationwide phenomenon and relies on the support of the rural population.The work also deals with the issues of land management, land management planning taking into account rational nature management and the land protection system. Conclusions. Land protection is becoming increasingly important as it affects the protection of the natural environment, including forests, waters, subsoil, wildlife and atmospheric air. Improving the state of land resources is a prerequisite for increasing the volume of agricultural production and creating an effective agricultural land market in Ukraine. Therefore, it is important to implement an effective model of land relations and build a perfect legal framework to ensure rational land use.

IntroductionDifficult choices between two equally attractive options result in a cognitive discrepancy between dissonant cognitions such as preferences and actions often followed by a sense of psychological discomfort known as cognitive dissonance. It can lead to changes in the desirability of options: the chosen option becomes more desirable, whereas the rejected option is devalued. Despite the ample experimental evidence to show this effect, the neural mechanisms and timing of such choice-induced preference changes are not fully understood.MethodsIn this study, we used transcranial direct current stimulation (tDCS) to modulate the activity of the posterior medial frontal cortex (pMFC), which has been associated with conflict monitoring and choice-induced preference changes in neuroimaging studies. Prior to a revised version of Brehm’s free-choice paradigm, participants in two experiments underwent cathodal (inhibitory) or anodal (excitatory) tDCS of the pMFC compared to sham (placebo) stimulation prior to the choice phase.ResultsOur results showed that cathodal tDCS significantly decreased the choice-induced preference change relative to a sham, but only in direct comparisons of rejected options. No significant effect of anodal tDCS in comparison with sham was observed.DiscussionThis study replicates the general behavioral effect of cognitive dissonance and provide partial support for the theory of the pMFC contribution to choice-related cognitive dissonance and subsequent preference changes, with possible limitations of an under-sampling for the obtained effect size and an asymmetry in the inhibitory-excitatory effects of non-invasive tDCS.

In the conditions of а mass disease, governing bodies of an economic system face a number of tasks related to the need to minimize its negative effects. This requires a tool that allows timely predicting the dynamics of the situation and determining what measures need to be taken. In this paper, a specialized mathematical model is proposed as such a tool, taking into account socio-biological and economic factors. The model is a dynamic optimal control problem with a delay in phase variables. The values of the model parameters were estimated using statistical data on the COVID-19 pandemic in the Russian Federation and the Ulyanovsk region. As target functionals, the following are considered: “social criterion” — a decrease in the number of cases; “economic criterion” — an increase in the relative profit of an economic system. To solve the problem, the authors apply a modification of the numerical parameterization method developed in their early studies. The article presents and analyzes the results of the numerical experiment aimed at studying the obtained optimal solutions. It is shown that: the optimal solution for social and economic criteria when changing budgets is stable; most of the parameters of the optimal solution are weakly elastic relative to the values of variables considered; the parameters of the optimal solution when using the economic criterion are more susceptible to change than when using the social criterion; the nature of the change in the parameters of the optimal solution for the Ulyanovsk region and for the Russian Federation is similar. Thus, the paper offers a tool for analyzing an economic problem in conditions of mass disease and confirms the applicability of the tool for finding optimal management strategies in various economic systems.

The proposed article describes the methodology for performing a multi-stage mathematical-informational task "Newton's Method for Complex Polynomials", aimed at developing the creative qualities of students. It notes creative activities that the student performs in the course of solving multifaceted problems. A scheme-plan for the implementation of a multi-stage mathematical and information task has been built. Examples of Julia sets of rational functions obtained by applying Newton's method to polynomials are given. The aesthetics of Julia sets are indicated, with the help of which students are invited to create artistic compositions. The integration of mathematics and programming is mentioned. The creative qualities have been identified, which are formed in students in the process of performing multi-stage mathematical and information task. When performing the tasks, students establish connections between iterations of rational functions of a complex variable and quadratic polynomials, discover for themselves Julia sets having complex fractal structure. They analytically calculate the fixed points of rational functions, determining their character. At the next stages, the study is visualized: with the help of a computer program, the orbits of the points of the studied functions and their Julia set are built. The introduction of color classification for different points allows you to get a more informative image of the fractal. The resulting image at the final stage is used to create some artistic compositions. The proposed method of function study makes it possible to develop flexibility of thinking, intuition, overcome stereotypes of thinking, develop aesthetic ideas, which positively affects the development of students' creative qualities.

Geopolitical tensions are on the rise. The competitive struggle in the field of educational services export does not stand aside either. In a fierce confrontation, a rich arsenal of modern technologies is used. Using the information onslaught, the ideology, the mentality of the younger generation, its worldview positions become the goal of this struggle. Russia has always been a competitive country in the export of educational services. However, in today’s conditions of fierce competition, it is necessary to defend one’s positions, find advantages in the Russian educational system, relying both on accumulated experience and using innovative approaches. In order to be competitive in the modern world community, during the transition to a new technological order, it is necessary to offer innovative products in the field of education, expand the range of the subjects of the educational environment on various regional platforms.

Successful achievement of the 17 Sustainable Development Goals (SDGs), including SDG 7: Affordable and Clean Energy, is impossible without proper financial support, especially after the devastating impact of the COVID-19 pandemic. Despite more than million academic papers related to SDG 7, only very few of them address the financial aspects of achieving SDG 7. To test the hypothesis, “SDG 7 related academic studies ignore the issue of investment in general and responsible investment in particular”, a meta-analysis is performed that includes a number of specific instruments and technics such as SciVal by Elsevier, VosViewer, Google trends, Google Books Ngram Viewer and Google Data. The results show a lack of appropriate academic support (methodology, empirical results, econometric models etc.) for practitioners to fill the existing financial gap and successfully achieve SDG 7. Among 1.2 million SDG 7 related papers, less than 100 deal with the financial gap problem measured by trillions of dollars in achieving SDG 7. This paper identifies the most promising and relevant topics for study related to SDG 7 and investment: the impact of the pandemic on decisions in the energy sector; efficiency of SDG 7 investment support and methodology for its assessment; green bonds, green loans, sovereign green bonds as responsible investment tools to advance SDG 7. Acknowledgments Inna Makarenko gratefully acknowledges support from the Supreme Council of Ukraine (0122U201796).The research was supported by the Scientific Grant Agency of the Ministry of Education, Science, Research, and Sport of the Slovak Republic and the Slovak Academy Sciences (VEGA), project No 1/0364/22: Research on eco-innovation potential of SMEs in the context of sustainable development.

The aim of the study was to evaluate the feasibility of using single-photon emission computed tomography (SPECT) with [99mTc]Tc-1-THIO-D-glucose in the detection of brain tumor malignancy. Material and methods. The study included 70 patients diagnosed with grade II–Iv malignant brain tumors and 10 patients with benign brain tumors. The control group consisted of 20 patients who had no pathological changes in the brain at the time of diagnosis. All patients underwent single-photon emission computed tomography of the brain 40 minutes after intravenous injection of [99mTc]Tc-1-THIO-D-glucose at a dose of 500 MBq. The [[99mTc]Tc-1-THIO-D-glucose radiopharmaceutical was prepared directly in the nuclear medicine department in strict accordance with the instructions. The head and neck of the patient fell into the field of view of the detectors of the gamma camera, 32 projections were recorded in a matrix of 256×256 pixels without hardware magnification. High-resolution low-energy collimators were used. Results. In patients with verified diagnosis of malignant brain tumors, SPECT with [99mTc]Tc-1-THIO-D-glucose correctly visualized tumors in all cases. The tumor was visualized as a zone of increased accumulation of [99mTc]Tc-1-THIO-D-glucose of varying intensity and size. However, benign brain lesions did not show [99mTc]Tc-1-THIO-D-glucose uptake. Physiological accumulation of [99mTc]Tc-1-THIO-D-glucose was observed in soft tissues of the aponeurotic helmet, the choroid of the brain, the mucous membranes of the nasal cavity, and the sinuses of the skull bones. Pathological changes in the brain revealed by SPECT were confirmed by MRI with contrast enhancement. Conclusion. The study demonstrated a high efficiency of SPECT with [99mTc]Tc-1-THIO-D-glucose in visualization of malignant brain tumors. The sensitivity, specificity and accuracy of SPECT with [99mTc]Tc-1-THIO-D-glucose in the imaging of malignant brain tumors were 93–100 %, 65–100 %, 95–100 %, respectively. The data obtained suggest that [99mTc]Tc-1-THIO-D-glucose SPECT as an additional method for the detection of malignant brain tumors can increase access to radionuclides for this group of patients and improve the quality of cancer care.

Introduction. In modern oncology, the identification of sentinel lymph nodes (SLN), the first nodes that stand on the way of malignant tumor metastasis, is of increasing interest. Detection of SLN followed by morphological examination allows personalizing the surgical intervention for early breast cancer, melanoma, head and neck tumors, neoplasms of the cervix and endometrium. Currently, there is an active development of specific radiopharmaceuticals for SLN imaging. Within the framework of the grant from the Federal Target Program "Pharma-2020", an original radiopharmaceutical using gamma aluminum oxide – [99mТс]-Al2O3 was developed. Preclinical studies have been demonstrated its effectiveness and safety. Pharmacokinetic studies of [99mTc]-Al2O3 showed that 24 hours after its subcutaneous administration, about 12 % of the administered dose is accumulated in the SLN, which gives possibility for its detection.Aim. To study the possibility of clinical [99mTc]-Al2O3 using for visualization of SLN in breast, larynx and laryngopharyngeal cancer.Materials and methods. The definition of SLN was carried out in 55 patients with breast cancer and 30 patients with malignant tumors of the larynx and laryngopharynx. The study included peritumoral radiopharmaceutical injection, single-photon emission computed tomography with qualitative and quantitative analysis of the images and radioguided surgery detection of lymph nodes with their subsequent morphological examination.Results and discussion. Clinical studies have shown that radionuclide imaging of SLN using [99mTc]-Al2O3 is characterized by high sensitivity in breast cancer, larynx and laryngopharyngeal cancer patients (94.5 and 90 %, respectively), due to the high-intensity accumulation of this radiopharmaceutical in the lymph nodes. The optimal time point for SPECT and radioguided examination is an interval of 18–20 hours after injection of [99mTc]-Al2O3, which allows visualizing the maximum possible number of lymph nodes with the most optimal level of radioactivity for their detection.Conclusion. Application of radionuclide imaging of SLN with the use of [99mTc]-Al2O3 as a radiopharmaceutical is useful in planning surgical treatment of patients with tumors of the breast, larynx and laryngopharynx to determine the extent of surgery.

The article is devoted to solving the problems of predicting the education of Ukrainian staff in the current COVID-2019 conditions in order to improve the efficiency of their work. Theoretical approaches regarding the characteristics of modeling and prediction of education have been studied, systematic and summarized. Factors that significantly complement the theory and methodology of the scientific provisions of the economy have been identified, taking into account the peculiarities of their work in the modern economic environment, structural changes, and new changes. The pros and cons of studying modeling approaches have been identified. The main features of structural change have been studied and it has been established that the modeling and forecasting of staff education has significant features.

The article examines the development of theoretical and methodological approaches and practical recommendations for improving the ecological and economic foundations of land management and land management at the local level in the example of the European Union.In practice, regional, spatial, strategic, landscape, and integrated types of land use development planning are most often used in the European Union. With the development of the market economy of European society, environmental problems arose, which prompted the development of landscape planning, both landscape-ecological and socio-economic aspects of territorial development. The experience of landscape planning was introduced in Germany, which later became used in almost all European countries.The study and direct comparison of existing landscape planning systems in different European countries, and their reduction to several basic features are not possible and impractical because these systems are very different. This is due to a number of reasons: history, features of political systems, cultural traditions, level of economic development, the nature of legal systems and property relations. Landscape planning in the European Union is going to be one of the tensest areas of activity in the future, and Ukraine must take an active part in this process.

A study of Smart City functioning leads to the conclusion that Fourth Industrial Revolution poses threatening challenges, which require the close attention of scientists to eliminate existential threats to humanity and turn the Smart City functioning into a human centred system. The analysis of indicators and descriptors that determine the content of the smart city phenomenon and the essence of this concept remains relevant nowadays. The purpose of the article is to analyse the Smart Cities global network, countries, regional clusters and the urbanisation scale for the possible potential threats emergence to the artificial intelligence application in the Smart City: socio-economic, ethical, psychological, environmental and political. Using the methods of foresight, benchmarking and comparative analysis the authors have formulated and revealed the content of the political and reputational nature threats. These threats are linked to increasing polarisation in society, “hybrid” wars emergence, personal data losses, the labour market and employments problems, increasing ecological pressure on the environment and the line blurring between machine and human. The results of the study contribute to knowledge about the potential and negative aspects of the information technologies use in urban environments.

The Horizon Europe project ISIDORe is dedicated to pandemic preparedness and responsiveness research. It brings together 17 research infrastructures (RIs) and networks to provide a broad range of services to infectious disease researchers. An efficient and structured treatment of data is central to ISIDORe’s aim to furnish seamless access to its multidisciplinary catalogue of services, and to ensure that users’ results are treated FAIRly. ISIDORe therefore requires a data management plan (DMP) covering both access management and research outputs, applicable over a broad range of disciplines, and compatible with the constraints and existing practices of its diverse partners. Here, we describe how, to achieve that aim, we undertook an iterative, step-by-step, process to build a community-approved living document, identifying good practices and processes, on the basis of use cases, presented as proof of concepts. International fora such as the RDA and EOSC, and primarily the BY-COVID project, furnished registries, tools and online data platforms, as well as standards, and the support of data scientists. Together, these elements provide a path for building an umbrella, FAIR-compliant DMP, aligned as fully as possible with FAIR principles, which could also be applied as a framework for data management harmonisation in other large-scale, challenge-driven projects. Finally, we discuss how data management and reuse can be further improved through the use of knowledge models when writing DMPs and, how, in the future, an inter-RI network of data stewards could contribute to the establishment of a community of practice, to be integrated subsequently into planned trans-RI competence centres.