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4. The Cochlea

Author

Rybak, Leonard P., Ramkumar, Vickram, editor, and Rybak, Leonard P., editor

Published
2018
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17. Drug-Induced Hearing Loss

Author

Rybak, Leonard P., Talaska, Andra E., Schacht, Jochen, Fay, Richard R., editor, Popper, Arthur N., editor, and Schacht, Jochen, editor

Published
2008
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24. Role of [beta]-arrestin1/ERK MAP kinase pathway in regulating adenosine [A.sub.1] receptor desensitization and recovery

Author

Jajoo, Sarvesh, Mukherjea, Debashree, Kumar, Sunny, Sheth, Sandeep, Kaur, Tejbeer, Rybak, Leonard P., and Ramkumar, Vickram

Subjects
Adenosine -- Physiological aspects, Adenosine -- Genetic aspects, Cell receptors -- Physiological aspects, Cell receptors -- Research, Mitogen-activated protein kinases -- Physiological aspects, Mitogen-activated protein kinases -- Genetic aspects, Biological sciences
Abstract

Am J Physiol Cell Physiol 298: C56-C65, 2010. First published October 14, 2009; doi:10.1152/ajpcell.00190.2009.--Exposure of cells to adenosine receptor (AR) agonists leads to receptor uncoupling from G proteins and downregulation of the [A.sub.1]AR. The receptor levels on the cell surface generally recover on withdrawal of the agonist, because of either translocation of the sequestered [A.sub.1]AR back to plasma membrane or de novo synthesis of [A.sub.1]AR. To examine the mechanism(s) underlying [A.sub.1]AR downregulation and recovery, we treated ductus deferens tumor ([DDT.sub.1] MF-2) cells with the agonist R-phenylisopropyladenosine (R-PIA) and showed a decrease in membrane [A.sub.1]AR levels by 24 h, which was associated with an unexpected 11-fold increase in [A.sub.1]AR mRNA. Acute exposure of these cells to R-PIA resulted in a rapid translocation of [beta]-arrestin1 to the plasma membrane. Knockdown of [beta]-arrestin1 by short interfering RNA (siRNA) blocked R-PIA-mediated downregulation of the [A.sub.1]AR, suppressed R-PIA-dependent ERK1/2 and activator protein-1 (AP-1) activity, and reduced the induction of [A.sub.1]AR mRNA. Withdrawal of the agonist after a 24-h exposure resulted in rapid recovery of plasma membrane [A.sub.1]AR. This was dependent on the de novo protein synthesis and on the activity of ERK1/2 but independent of [beta]-arrestin1 and nuclear factor-[kappa]B. Together, these data suggest that exposure to [A.sub.1]AR agonist stimulates ERK1/2 activity via [beta]-arrestin1, which subserves receptor uncoupling and downregulation, in addition to the induction of [A.sub.1]AR expression. We propose that such a pathway ensures both the termination of the agonist signal and recovery by priming the cell for rapid de novo synthesis of [A.sub.1]AR once the drug is terminated. G protein-coupled receptor; activator protein-1 transcription factor; radioligand binding; short interfering RNA

Published
2010

26. Contributors

Author

Agrawal, Sumit K., Anderson, Shane R., Arriaga, Moisés A., Aylward, Alana, Banakis Hartl, Renee M., Berenholz, Leonard P., Brackmann, Derald E., Brown, C. Scott, Carey, John P., Carrau, Ricardo L., Casazza, Geoffrey C., Cass, Nathan D., Cass, Stephen P., Cassis, Adam M., Chang, Ray C., Chen, Douglas A., Christopher, Laura H., Connell, Sarah S., Corrales, C. Eduardo, Crane, Benjamin T., Crowson, Matthew G., Cullen, Robert D., Cumpston, Evan C., DeTorres, Alvin, Dewyer, Nicholas A., Dornhoffer, John, Eppsteiner, Robert W., Erbele, Isaac D., Eshraghi, Adrien A., Fayad, Jose N., Friedman, Rick A., Gantz, Bruce J., Gardner, Gale, Gary, Celeste C., Goddard, John C., Gubbels, Samuel P., Gurgel, Richard K., Handzel, Ophir, Hetzler, Laura T., Hillman, Todd A., House, John W., Isaacson, Brandon, Jackler, Robert K., Jenkins, Herman A., Jones, Joel W., Kassam, Amin B., Kaylie, David M., Kesser, Bradley W., Kutz, J. Walter, Jr., Lee, John Y.K., Lippy, William H., Littlefield, Philip D., Liu, Yuan F., London, Nyall R., Jr., Lupo, J. Eric, Mahboubi, Hossein, Manzoor, Nauman, Maxwell, Anne K., McElveen, John T., Jr., McKenna, Michael J., McRackan, Theodore R., Mehta, Rahul, Minor, Lloyd B., Monsell, Edwin M., Muelleman, Thomas J., Nadol, Joseph B., Jr., Nassiri, Ashley M., Netterville, James L., Otto, Steven R., Parnes, Lorne S., Patel, Neil S., Peng, Kevin A., Perry, Brian P., Poe, Dennis S., Prevedello, Daniel M., Redleaf, Miriam I., Rivas, Alejandro, Roberson, Joseph B., Jr., Roberts, Daniel S., Roche, Joseph P., Roland, Peter S., Rybak, Leonard P., Santa Maria, Peter L., Schwam, Zachary G., Schwartz, Marc S., Shea, Martin Coyle, Jr., Sheehy, James L., Shelton, Clough, Shibata, Seiji B., Sinha, Saurabh, Slattery, William H., III, Sowder, Justin C., Sullivan, C. Blake, Sullivan, Christopher A., Syms, Charles A., III, Syms, Mark, Tawfik, Kareem O., Telian, Steven A., Telischi, Fred F., Tjellström, Anders, Wackym, P. Ashley, Wanna, George B., Ward, P. Daniel, Weiner, Joseph P., Weinreich, Heather M., Wiet, R. Mark, Wiet, Richard J., and Wilkinson, Eric P.

Published
2023
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27. Contributors

Author

Adunka, Oliver F., primary, Arriaga, Moisés A., additional, Ator, Gregory A., additional, Benecke, James E., additional, Berenholz, Leonard P., additional, Boyev, K. Paul, additional, Brackmann, Derald E., additional, Buchman, Craig A., additional, Carey, John P., additional, Carrau, Ricardo L., additional, Cass, Stephen P., additional, Chang, Ray C., additional, Chen, Douglas A., additional, Chen, Henry H., additional, Chen, Joseph M., additional, Connell, Sarah S., additional, Crane, Benjamin T., additional, De la Cruz, Antonio, additional, Cullen, Robert D., additional, Cunningham, Calhoun D., additional, Dashti, Shervin R., additional, Jennifer Derebery, M., additional, Desai, Shaun C., additional, Deshmukh, Vivek R., additional, Dornhoffer, John L., additional, Eshraghi, Adrien A., additional, Fayad, Jose N., additional, Fisch, Ugo, additional, Friedland, David R., additional, Friedman, Rick A., additional, Fukushima, Takanori, additional, Gantz, Bruce J., additional, Gardner, Gale, additional, Gardner, Paul A., additional, Giddings, Neil A., additional, Glasscock, Michael E., additional, Gubbels, Samuel P., additional, Handzel, Ophir, additional, Harvey, Steven A., additional, Hillman, Todd A., additional, Hitselberger, William E., additional, Hoskins, Barbara Stahl, additional, House, Howard P., additional, House, John W., additional, House, William F., additional, Isaacson, Brandon B., additional, Jackler, Robert K., additional, Gary Jackson, C., additional, Janecka, Ivo P., additional, Jannetta, Peter J., additional, Jenkins, Herman A., additional, Kassam, Amin B., additional, Kaylie, David M., additional, Kesser, Bradley W., additional, Kutz, Joe W., additional, Kwartler, Jed A., additional, Leonetti, John P., additional, Levine, Robert E., additional, Lin, James, additional, Lippy, William H., additional, Littlefield, Philip D., additional, Lo, Teresa M., additional, Lundy, Larry B., additional, Luxford, William M., additional, McElveen, John T., additional, McKenna, Michael J., additional, Minor, Lloyd B., additional, Monsell, Edwin M., additional, Nadol, Joseph B., additional, Nedzelski, Julian M., additional, Gail Neely, J., additional, Netterville, James L., additional, Otto, Steven R., additional, Packer, Mark D., additional, Parnes, Lorne S., additional, Perkins, Rodney, additional, Perry, Brian P., additional, Pilkington, Thomas M., additional, Poe, Dennis S., additional, Prasad, Sanjay, additional, Prevedello, Daniel M., additional, Redleaf, Miriam I., additional, Roberson, Joseph B., additional, Roberts, Michael A., additional, Robinson, Mendell, additional, Rodgers, Grayson K., additional, Roland, Peter S., additional, Runge-Samuelson, Christina L., additional, Rybak, Leonard P., additional, Schaitkin, Barry M., additional, Schuknecht, Harlod F., additional, Sekula, Raymond F., additional, Shannon, Robert V., additional, Shea, M. Coyle, additional, Sheehy, James L., additional, Shelton, Clough, additional, Sim, David W., additional, Singleton, George T., additional, Slattery, William H., additional, Snyderman, Carl H., additional, Spetzler, Robert F., additional, Strasnick, Barry, additional, Sullivan, Christopher A., additional, Syms, Mark J., additional, Syms, Charles A., additional, Telian, Steven A., additional, Telischi, Fred F., additional, Teufert, Karen B., additional, Tjellström, Anders M.R., additional, Tucci, Debara L., additional, Wackym, P. Ashley, additional, Daniel Ward, P., additional, Warren, Frank M., additional, Welling, D. Bradley, additional, Wiet, Richard J., additional, and Wilkinson, Eric P., additional

Published
2010
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29. Contributors

Author

Abuzeid, Waleed M., primary, Adams, Meredith E., additional, Adamson, Peter A., additional, Adenis, Antoine, additional, Akst, Seth, additional, Albers, Sheri L., additional, Albert, David, additional, Alexander, Ronda E., additional, Archbold, Sue, additional, Armstrong, William B., additional, Arriaga, Moisés A., additional, Arts, H. Alexander, additional, Ashram, Yasmine A., additional, Aviv, Jonathan E., additional, Aygun, Nafi, additional, Backous, Douglas D., additional, Baker, Shan R., additional, Balkany, Thomas J., additional, Baloh, Robert W., additional, Barkmeier-Kraemer, Julie, additional, Baroody, Fuad M., additional, Bartlett, Nancy L., additional, Baskin, Jonathan Z., additional, Bastian, Robert W., additional, Bauer, Carol A., additional, Benninger, Michael S., additional, Bhama, Prabhat K., additional, Bhatti, Nasir Islam, additional, Blitzer, Andrew, additional, Boardman, Simone, additional, Boss, Emily F., additional, Brackmann, Derald E., additional, Bradford, Carol R., additional, Branstetter, Barton F., additional, Braun, Edward B., additional, Briggs, Robert J.S., additional, Brodie, Hilary A., additional, Brown, Carolyn J., additional, Brown, David J., additional, Brown, Kevin D., additional, Browne, J. Dale, additional, Buatti, John M., additional, Buchmann, Luke, additional, Byrne, Patrick J., additional, Galzada, Gabriel G., additional, Carey, John P., additional, Casselbrant, Margaretha L., additional, Castelnuovo, Paolo, additional, Chang, Steven, additional, Chegar, Burke E., additional, Chen, Amy, additional, Chen, Eunice Y., additional, Chen, Theodore, additional, Chepeha, Douglas B., additional, Cheuk, Alice, additional, Chheda, Neil N., additional, Chien, Wade, additional, Choi, Sukgi S., additional, Chole, Richard A., additional, Christian, James M., additional, Chu, Eugene A., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Collins, Savita, additional, Collop, Nancy A., additional, Contencin, Philippe, additional, Cook, Raymond, additional, Corey, Jacquelynne, additional, Cotton, Robin T., additional, Couch, Marion Everett, additional, Courey, Mark S., additional, Crane, Benjamin T., additional, Crumley, Roger L., additional, Cruz, Oswaldo Laércio M., additional, Culicchia, Frank, additional, Cummings, Charles W., additional, Cunningham, Calhoun D., additional, Davis, Greg E., additional, Davis, Larry E., additional, Day, Terry A., additional, De la Cruz, Antonio, additional, Santina, Charles C. Della, additional, Denlinger, Chadrick, additional, Derkay, Craig S., additional, Diaz, Rodney C., additional, Dobie, Robert A., additional, Galli, Suzanne K. Doud, additional, Duncan, Newton O., additional, Eggers, Scott D.Z., additional, Eisbruch, Avraham, additional, Eisele, David W., additional, El-Kashlan, Hussam K., additional, Elluru, Ravindhra G., additional, Ende, Kevin H., additional, Erman, Audrey B., additional, Fakhri, Samer, additional, Fakhry, Carole, additional, Farrior, Edward H., additional, Farrior, Richard T., additional, Faust, Russell A., additional, Ferguson, Berrylin J., additional, Flint, Paul W., additional, Francis, Howard W., additional, Fried, Marvin P., additional, Friedland, David R., additional, Friedman, Oren, additional, Frodel, John L., additional, Funk, Gerry F., additional, Gantz, Bruce J., additional, Garrett, C. Gaelyn, additional, Gartner-Schmidt, Jackie, additional, Gay, William Donald, additional, Ge, Norman N., additional, Gillespie, M. Boyd, additional, Girod, Douglas A., additional, Goding, George S., additional, Goldberg, Andrew N., additional, Goldenberg, David, additional, Graney, Daniel O., additional, Grant, Nazaneen N., additional, Grégoire, Vincent, additional, Gries, Heike, additional, Gubbels, Samuel P., additional, Guss, Joel, additional, Ha, Patrick, additional, Hamilton, Grant S., additional, Hanna, Ehab Y., additional, Harker, Lee A., additional, Harréus, Uli, additional, Harrison, Robert V., additional, Haughey, Bruce H., additional, Hellstein, John W., additional, Herzer, Kurt, additional, Hildebrand, Michael S., additional, Hilgers, Frans J.M., additional, Hill, Justin D., additional, Hinni, Michael L., additional, Hoffman, Henry T., additional, Holbrook, Eric H., additional, Holinger, Lauren D., additional, Holzapfel, Allison MacGregor, additional, Hom, David B., additional, House, John W., additional, House, Joyce Colton, additional, Hullar, Timothy E., additional, Husein, Murad, additional, Ing, Steven, additional, Iseli, Tim A., additional, Ishman, Stacey, additional, Jackler, Robert K., additional, Jameson, Brian, additional, Jenkins, Herman A., additional, Jin, Hong-Ryol, additional, Joe, John K., additional, Joe, Stephanie A., additional, Johnson, Gary, additional, Johnson, Rhonda, additional, Johnson, Tiffany A., additional, Johnson, Timothy M., additional, Jones, Nick S., additional, Kabaker, Sheldon S., additional, Karnell, Lucy H., additional, Kashima, Matthew L., additional, Kellman, Robert M., additional, Kelly, Paul E., additional, Kennedy, David W., additional, Khalid, Ayesha N., additional, Kies, Merrill S., additional, Kileny, Paul R., additional, Kim, David W., additional, Kim, Jason H., additional, Kim, Theresa B., additional, Kimberling, William J., additional, Koh, Jeffrey, additional, Kokot, Niels, additional, Koltai, Peter J., additional, Kozak, Frederick K., additional, Krakovitz, Paul R., additional, Kridel, Russell W.H., additional, Kumar, Parvesh, additional, Kunduk, Melda, additional, Laccourreye, Ollivier, additional, Lacey, JoAnne, additional, Lai, Stephen Y., additional, Lal, Devyani, additional, Lalwani, Anil K., additional, Lambert, Paul R., additional, Lassig, Amy Anne, additional, Latchaw, Richard E., additional, Leahy, Kevin P., additional, Lee, Daniel J., additional, Lee, Ken K., additional, Lee, Nancy, additional, Lefebvre, Jean-Louis, additional, Lefton-Greif, Maureen A., additional, Leopold, Donald A., additional, Lewis, James S., additional, Li, Daqing, additional, Lian, Timothy S., additional, Licameli, Greg R., additional, Limb, Charles J., additional, Logemann, Jeri A., additional, Loh, Thomas, additional, Lonsbury-Martin, Brenda L., additional, Lopez, Manuel A., additional, Lusk, Rodney P., additional, Lustig, Lawrence R., additional, Lysakowski, Anna, additional, MacArthur, Carol J., additional, Maisel, Robert H., additional, Malone, James P., additional, Mandel, Ellen M., additional, Mandel, Susan J., additional, Manning, Scott C., additional, Mark, Lynette, additional, Markt, Jeffery C., additional, Marsh, Michael, additional, Martin, Glen K., additional, Mattox, Douglas E., additional, McCaffrey, Thomas V., additional, McCulloch, Timothy M., additional, McGee, JoAnn, additional, McGuire, John F., additional, McJunkin, Jonathan, additional, McMurray, J. Scott, additional, Merati, Albert L., additional, Merchant, Saumil N., additional, Messner, Anna H., additional, Michelson, James, additional, Milczuk, Henry A., additional, Minor, Lloyd B., additional, Mobley, Steven Ross, additional, Muntz, Harlan, additional, Murakami, Craig S., additional, Myer, Charles M., additional, Naclerio, Robert M., additional, Nadol, Joseph B., additional, Nassif, Paul S., additional, Nedzelski, Julian, additional, Nicolai, Piero, additional, Nielsen, David R., additional, Niparko, John K., additional, Norton, Susan J., additional, Nouraei, S.A. Reza, additional, Nuss, Daniel W., additional, Nussenbaum, Brian, additional, Odland, Rick M., additional, O'Donoghue, Gerard, additional, Oliver, Eric R., additional, O’Malley, Bert W., additional, O’Reilly, Robert C., additional, Ospina, Juan Camilo, additional, Ossoff, Robert H., additional, Otto, Kristen J., additional, Packer, Mark D., additional, Pallanch, John, additional, Palmer, James N., additional, Park, Stephen S., additional, Patel, Sundip, additional, Patterson, G. Alexander, additional, Pearson, Bruce W., additional, Pellitteri, Phillip K., additional, Perkins, Jonathan A., additional, Perkins, Stephen W., additional, Pero, Colin D., additional, Pignatari, Shirley S.N., additional, Pletcher, Steven D., additional, Popovtzer, Aron, additional, Postma, Gregory N., additional, Potsic, William P., additional, Poznanovic, Sheri A., additional, Quatela, Vito C., additional, Rabinov, C. Rose, additional, Ramachandran, Virginia, additional, Randolph, Gregory W., additional, Rassekh, Christopher H., additional, Rauch, Steven D., additional, Reinisch, Lou, additional, Richardson, Mark, A., additional, Richter, Gresham T., additional, Ridgway, James M., additional, Robbins, K. Thomas, additional, Roediger, Frederick C., additional, Rogers, Jeremy, additional, Ronen, Ohad, additional, Rosenfeld, Richard M., additional, Rotter, Bruce E., additional, Rubinstein, Jay T., additional, Ruckenstein, Michael J., additional, Rumboldt, Zoran, additional, Runge-Samuelson, Christina L., additional, Rybak, Leonard P., additional, Sadoughi, Babak, additional, Salassa, John R., additional, Salinas, Thomas J., additional, Samant, Sandeep, additional, Samlan, Robin A., additional, Samy, Ravi N., additional, Sandel, Henry D., additional, Sandhu, Guri S., additional, Sando, Isamu, additional, Sauder, Cara, additional, Scarlett, Jeremy A., additional, Scher, Richard L., additional, Schessel, David A., additional, Schmalbach, Cecelia E., additional, Schwedt, Todd J., additional, Sciubba, James J., additional, Sequeira, Sunitha, additional, Seshamani, Meena, additional, Shelton, Clough, additional, Shepard, Neil T., additional, Ship, Jonathan A., additional, Shirley, W. Peyton, additional, Shnayder, Yelizaveta, additional, Shvidler, Joseph, additional, Sie, Kathleen C.Y., additional, Simmen, Daniel B., additional, Smith, Marshall E., additional, Smith, Richard J.H., additional, Sofferman, Robert A., additional, Soma, Marlene, additional, Stach, Brad A., additional, Staecker, Hinrich, additional, Stamm, Aldo Cassol, additional, Stankiewicz, James A., additional, Stavinoha, Rose, additional, Sterni, Laura M., additional, Steward, David L., additional, Stocks, Rose Mary S., additional, Sudhoff, Holger H., additional, Sunwoo, John B., additional, Swanson, Neil A., additional, Swanson, Veronica C., additional, Swarm, Robert A., additional, Sykes, Jonathan M., additional, Tan, Luke, additional, Tardy, M. Eugene, additional, Tatum, Sherard A., additional, Taylor, S. Mark, additional, Teissier, Natacha, additional, Telian, Steven A., additional, Terris, David J., additional, Teufert, Karen B., additional, Thomas, J. Regan, additional, Thompson, James N., additional, Toriumi, Dean M., additional, Torres, Alejandro I., additional, Travers, Joseph B., additional, Travers, Susan P., additional, Tsue, Terance T., additional, Tufano, Ralph P., additional, Tunkel, David E., additional, Turner, Michael D., additional, Uppaluri, Ravindra, additional, Vaezi, Michael F., additional, Van den Abbeele, Thierry, additional, van den Brekel, Michiel W.M., additional, Vaysberg, Mikhail, additional, Vokes, David E., additional, Wackym, P. Ashley, additional, Wakefield, Tamekia L., additional, Walner, David L., additional, Walsh, Edward J., additional, Walvekar, Rohan R., additional, Wang, Tom D., additional, Warren, Frank M., additional, Weber, Randal S., additional, Wein, Richard O., additional, Weinstein, Gregory S., additional, Weitzel, Erik Kent, additional, Welling, D. Bradley, additional, Wemer, Richard D., additional, Wetmore, Ralph F., additional, Weymuller, Ernest A., additional, Wiatrak, Brian J., additional, Wiet, Gregory J., additional, Wiggins, Richard H., additional, Willey, Andrea, additional, William, William N., additional, Williams, Glenn B., additional, Wippold, Franz J., additional, Woodson, Gayle Ellen, additional, Woolley, Audie L., additional, Wootten, Christopher T., additional, Wormald, Peter-John, additional, Yingling, Charles D., additional, Yueh, Bevan, additional, Yung, Rex C., additional, Zaldívar, Renzo A., additional, Zalzal, George H., additional, Zee, David S., additional, Zimbler, Marc S., additional, Zinreich, S. James, additional, and Zwolan, Teresa A., additional

Published
2010
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41. Identification of A1 adenosine receptors in rat cochlea coupled to inhibition of adenylyl cyclase

Author

Ramkumar, Vickram, Ravi, Radhika, Wilson, Marty C., Gettys, Thomas W., Whitworth, Craig, and Rybak, Leonard P.

Subjects
Adenylate cyclase -- Inhibitors, Cell receptors -- Research, Polymerase chain reaction -- Observations, Biological sciences
Abstract

Radioligand binding, PCR amplification of reverse-transcribed RNA and photoaffinity labeling of A1 adenosine receptors (A1AR) in rat cochlea reveal the association of the receptor with adenylyl cyclase activity inhibition through Gi proteins. Specific labeling of a 36-kDa receptor is identified by photoaffinity labeling of the receptor with its agonist. PCR amplification of the reverse-transcribed RNA results in a A1AR cDNA hybridizing 770-bp product.

Published
1994

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