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4. Report-Back of Personal Air Sampling Results and Study Participants' Perceived Knowledge, Attitudes, and Awareness of Air Pollution

Author

Ryan, Patrick H., Wolfe, Chris, Parsons, Allison, Brokamp, Cole, Turner, Ashley, Ingram, Sherrill, and Haynes, Erin

Subjects
Biological monitoring -- Reports, Geospatial data -- Reports, Air pollution -- Reports, Environmental issues, Health
Abstract

Introduction Report-back of chemical exposure data to participants in biomonitoring studies has been shown to be beneficial to participants and researchers, and guidebooks are available regarding best practices to develop [...]

Published
2023
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5. Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

Author

Smith, P.B., Newby, K.L., Jacobson, L.P., Catellier, D.J., Gershon, R., Cella, D., Alshawabkeh, A., Aschner, J., Merhar, S., Ren, C., Reynolds, A., Keller, R., Pryhuber, G., Duncan, A., Lampland, A., Wadhawan, R., Wagner, C., Hudak, M., Mayock, D., Walshburn, L., Teitelbaum, S.L., Stroustrup, A., Trasande, L., Blair, C., Gatzke-Kopp, L., Swingler, M., Mansbach, J., Spergel, J., Puls, H., Stevenson, M., Bauer, C., Deoni, S., Duarte, C., Dunlop, A., Elliott, A., Croen, L., Bacharier, L., O’Connor, G., Kattan, M., Wood, R., Hershey, G., Ownby, D., Hertz-Picciotto, I., Hipwell, A., Karagas, M., Karr, C., Mason, A., Sathyanarayana, S., Lester, B., Carter, B., Neal, C., Smith, L., Helderman, J., Leve, L., Ganiban, J., Neiderhiser, J., Weiss, S., Zeiger, R., Tepper, R., Lyall, K., Landa, R., Ozonoff, S., Schmidt, R., Dager, S., Schultz, R., Piven, J., Volk, H., Vaidya, R., Obeid, R., Rollins, C., Bear, K., Pastyrnak, S., Lenski, M., Msall, M., Frazier, J., Washburn, L., Montgomery, A., Barone, C., McKane, P., Paneth, N., Elliott, M., Herbstman, J., Schantz, S., Porucznik, C., Silver, R., Conradt, E., Bosquet-Enlow, M., Huddleston, K., Bush, N., Nguyen, R., O'Connor, T., Samuels-Kalow, M., Miller, Rachel L., Schuh, Holly, Chandran, Aruna, Aris, Izzuddin M., Bendixsen, Casper, Blossom, Jeffrey, Breton, Carrie, Camargo, Carlos A., Jr., Canino, Glorisa, Carroll, Kecia N., Commodore, Sarah, Cordero, José F., Dabelea, Dana M., Ferrara, Assiamira, Fry, Rebecca C., Ganiban, Jody M., Gern, James E., Gilliland, Frank D., Gold, Diane R., Habre, Rima, Hare, Marion E., Harte, Robyn N., Hartert, Tina, Hasegawa, Kohei, Khurana Hershey, Gurjit K., Jackson, Daniel J., Joseph, Christine, Kerver, Jean M., Kim, Haejin, Litonjua, Augusto A., Marsit, Carmen J., McEvoy, Cindy, Mendonça, Eneida A., Moore, Paul E., Nkoy, Flory L., O’Connor, Thomas G., Oken, Emily, Ownby, Dennis, Perzanowski, Matthew, Rivera-Spoljaric, Katherine, Ryan, Patrick H., Singh, Anne Marie, Stanford, Joseph B., Wright, Rosalind J., Wright, Robert O., Zanobetti, Antonella, Zoratti, Edward, and Johnson, Christine C.

Published
2023
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8. Health Research in the Wake of Disasters: Challenges and Opportunities for Sensor Science

Author

Volckens, John, Haynes, Erin N., Croisant, Sharon P., Cui, Yuxia, Errett, Nicole A., Henry, Heather F., Horney, Jennifer A., Kwok, Richard K., Magzamen, Sheryl, Rappold, Ana G., Ravichandran, Lingamanaidu, Reinlib, Les, Ryan, Patrick H., and Shaughnessy, Daniel T.

Subjects
Environmental health -- Research, Disasters -- Health aspects -- Social aspects -- United States, Medical research -- Management, Medicine, Experimental -- Management, Sensors -- Usage -- Health aspects -- Environmental aspects, Company business management, Environmental issues, Health
Abstract

Background: Disaster events adversely affect the health of millions of individuals each year. They create exposure to physical, chemical, biological, and psychosocial hazards while simultaneously exploiting community and individual-level vulnerabilities that allow such exposures to exert harm. Since 2013, the National Institute of Environmental Health Sciences (NIEHS) has led the development of the Disaster Research Response (DR2) program and infrastructure; however, research exploring the nature and effects of disasters on human health is lacking. One reason for this research gap is the challenge of developing and deploying cost-effective sensors for exposure assessment during disaster events. Objectives: The objective of this commentary is to synergize the consensus findings and recommendations from a panel of experts on sensor science in support of DR2. Methods: The NIEHS convened the workshop, 'Getting Smart about Sensors for Disaster Response Research' on 28 and 29 July 2021 to discuss current gaps and recommendations for moving the field forward. The workshop invited full discussion from multiple viewpoints, with the goal of identifying recommendations and opportunities for further development of this area of research. The panel of experts included leaders in engineering, epidemiology, social and physical sciences, and community engagement, many of whom had firsthand experience with DR2. Discussion: The primary finding of this workshop is that exposure science in support of DR2 is severely lacking. We highlight unique barriers to DR2, such as the need for time-sensitive exposure data, the chaos and logistical challenges that ensue from a disaster event, and the lack of a robust market for sensor technologies in support of environmental health science. We highlight a need for sensor technologies that are more scalable, reliable, and versatile than those currently available to the research community. We also recommend that the environmental health community renew efforts in support of DR2 facilitation, collaboration, and preparedness. https://doi.org/10.1289/EHP12270, Introduction Disasters are on the rise around the world. (1) Notwithstanding the loss of housing and infrastructure, events such as hurricanes, floods, and wildland fires frequently expose individuals to chemical, [...]

Published
2023
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10. Pediatric asthma incidence rates in the United States from 1980 to 2017

Author

Johnson, Christine C., Havstad, Suzanne L., Ownby, Dennis R., Joseph, Christine L.M., Sitarik, Alexandra R., Biagini Myers, Jocelyn, Gebretsadik, Tebeb, Hartert, Tina V., Khurana Hershey, Gurjit K., Jackson, Daniel J., Lemanske, Robert F., Jr., Martin, Lisa J., Zoratti, Edward M., Visness, Cynthia M., Ryan, Patrick H., Gold, Diane R., Martinez, Fernando D., Miller, Rachel L., Seroogy, Christine M., Wright, Anne L., and Gern, James E.

Published
2021
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11. Air pollution, epigenetics, and asthma

Author

Ji, Hong, Biagini Myers, Jocelyn M, Brandt, Eric B, Brokamp, Cole, Ryan, Patrick H, and Khurana Hershey, Gurjit K

Subjects
Biomedical and Clinical Sciences, Immunology, Lung, Climate-Related Exposures and Conditions, Asthma, Genetics, Aetiology, 2.2 Factors relating to the physical environment, Respiratory, Traffic pollution, Epigenetics, Allergy
Abstract

Exposure to traffic-related air pollution (TRAP) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant as large segments of the global population resides in zones that are most impacted by TRAP and schools are often located in high TRAP exposure areas. Recent findings shed new light on the epigenetic mechanisms by which exposure to traffic pollution may contribute to the development and persistence of asthma. In order to delineate TRAP induced effects on the epigenome, utilization of newly available innovative methods to assess and quantify traffic pollution will be needed to accurately quantify exposure. This review will summarize the most recent findings in each of these areas. Although there is considerable evidence that TRAP plays a role in asthma, heterogeneity in both the definitions of TRAP exposure and asthma outcomes has led to confusion in the field. Novel information regarding molecular characterization of asthma phenotypes, TRAP exposure assessment methods, and epigenetics are revolutionizing the field. Application of these new findings will accelerate the field and the development of new strategies for interventions to combat TRAP-induced asthma.

Published
2016

12. Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

Author

Achten, Niek, Ainsworth, John, Akkerman, Nonna, Anderson, Elizabeth, Anderson, Larry J., Andrews, Howard, Armagost, Elizabeth, Aubuchon, Mary Ann, Bach, Julia, Bacharier, Leonard, Barnes, Kathrine L., Barone, Charles, Bauer, Irma, Beamer, Paloma, Becker, Patrice, Bednarek, Alyssa, Bellemore, Stacey, Bendixsen, Casper G., Biagini Myers, Jocelyn M., Billheimer, Dean, Billstrand, Christine, Birg, Geraldine, Blocki, Shirley, Bloomberg, Gordon, Bobbitt, Kevin, Bochkov, Yury, Bourgeois, Karen, Boushey, Homer, Brockman-Schneider, Rebecca, Brunwasser, Steven M., Budrevich, Richard, Burkle, Jeffrey W., Busse, William, Calatroni, Agustin, Campbell, Janice, Carlson-Dakes, Kirsten, Cassidy-Bushrow, Andrea, Chappell, James D., Chasman, Deborah, Chipps, Teresa M., Chirkova, Tatiana, Cole, Deanna, Connolly, Alexandra, Cootauco, Michelle, Costello, Kaitlin, Couch, Philip, Coull, Brent, Craven, Mark, Crisafi, Gina, Cruikshank, William, Curtsinger, Kristi, Custovic, Adnan, Das, Suman R., DaSilva, Douglas, Datta, Soma, Davidson, Brent, De La Ossa, Lydia, DeVries, Mark, Di, Qian, Dixon, Samara, Donnerbauer, Erin, Dorst, Marian, Doyle, Susan, Dresen, Amy, Dupont, William D., Durrange, Janet, Erickson, Heidi, Evans, Michael D., Ezell, Jerel, Farnham, Leanna, Filardo-Collins, Roxanne, Finazzo, Salvatore, Flege, Zachary, Fleurat, Conner, Floerke, Heather, Floerke, Dorothy, Foss, Terry, Freie, Angela, Frome, Wayne, Fye, Samantha, Gagalis, Lisa, Gammell, Rebecca, Gangnon, Ronald E., Ge, James E., Gebretsadik, Tebeb, Gergen, Peter, Gern, James E., Gibson, Heike, Gjerasi, Edlira, Gold, Diane R., Gonzalez, Nicole, Goodman, Kayla, Gress, Lisa, Grindle, Kristine, Groeschen, Taylor, Hallmark, Brian, Halonen, Marilyn, Hart, Jaime, Hartert, Tina V., Havstad, Suzanne, Heinritz, Patrick, Hensley Alford, Sharon, Herbstman, Julie, Hernandez, Kellie, Hoepner, Lori, Jackson, Daniel J., Jadhao, Samadhan J., Jaffee, Katy, James, Peter, Jezioro, Jacqueline, Jimenez Pescador, Marcia, Johnson, Christine C., Johnson, Tara, Johnson, Camille, Jones, Amelia, Jones, Kyra, Jones, Paul, Jordan, Carolina, Joseph, Christine LM, Kattan, Meyer, Keidel, Kristina, Keifer, Matthew C., Kelley, Rick, Khurana Hershey, Gurgit K., Kim, Haejin, Kloog, Itai, Koepel, Tammy Kronenwetter, Koerkenmeier, Clint, Ladick, Laura, Lamm, Carin, Larkin, Emma, Lederman, Howard, Lee-Parritz, Aviva, Leimenstoll, Stephanie, Lemanske, Jr., Robert F., LeMasters, Grace K., Levin, Albert M., Levine, Jessica, Liu, Xinhua, Liu, Zhouwen, Lopez, Silvia, Lothrop, Nathan, Lovinsky-Desir, Stephanie, Lukacs, Nicholas, Lynch, Susan, Lynch, Christian, Mann, Erik, Martin, Jennifer, Martin, Lisa, Martinez, Fernando D., Matsui, Elizabeth, McCauley, Katherine, Mccollum, Megan, McCullough, Judith, McKennon, Chris G., Meece, Jennifer, Mendonca, Eneida, Mikus, Lance, Miller, Rachel L., Minton, Patricia, Mitchell, Herman, Moon, Vicki, Moore, Paul E., Morgan, Wayne, Morgan, Valerie, Morgan, David, Murrison, Liza, Nicholas, Charlotte, Nicolae, Daniel, Nunez, Adam, O'Connor, George, O'Toole, Sharon, Ober, Carole, Olson, Brent F., Ong, Irene, Osmundson, Sarah, Ownby, Dennis, Pappas, Tressa, Perera, Frederica, Perzanowski, Matthew, Peterson, Edward, Pierce, Marcela, Price-Johnson, Penny, Rajamanickam, Victoria, Ramirez, Judyth, Ray, Kimberly, Renneberg, Megan, Requia, Weeberb, Riley, Kylie, Rivera, Janelle, Rivers, Neisha, Roberg, Kathy, Rogers, Theresa, Rosas-Salazar, Christian, Russell, Pat, Ryan, Patrick H., Sadovsky, Yoel, Salazar, Lisa, Sampson, Hugh, Sandel, Megan, Schoettler, Nathan, Schwartz, Joel, Scott, Dena, Seroogy, Christine M., Sharp, Renee, Shilts, Meghan H., Sigelman, Steve, Singh, Anne Marie, Sitarik, Alexandra, Smartt, Ernestine, Sorkness, Ronald, Sorkness, Christine, Spangenberg, Amber, Sperling, Rhoda, Spies, David, Stern, Debra A., Stoffel, Brandy, Peebles, R. Stokes, Stouffer, Gina, Strauchman Boyer, Cathey, Suddeuth, Caitlin, Tachinardi, Umberto, Tang, Deliang, Tang, Zhengzheng, Tate, Jena, Taylor, William, Tensing, Krista, Tesson, Elizabeth, Thompson, Kathy, Thompson, Emma, Tisler, Christopher, Togias, Alkis, Turi, Kedir, Turner, Victoria, Tuzova, Marina, VanWormer, Jeffrey J., Visness, Cynthia M., Vrtis, Rose, Wahlman, Anthony, Wang, Lena, Wegienka, Ganesa, Wells, Karen, Wentworth-Sheilds, William, Wheatley, Lisa, Whitney, Nitsa, Williams, L. Keoki, Witter, Frank, Wolfe, Christopher, Wood, Robert A., Woodcroft, Kimberley, Woodward, Kim B., Wright, Anne L., Wright, Rosalind, Wu, Pingsheng, Yaeger, Melissa, Yaniv, Perri, Zanobetti, Antonella, Zhang, Shirley, Zook, Patricia, Zoratti, Edward M., McKennan, Chris G, Magnaye, Kevin M, Altman, Matthew C, Washington, Charles, 3rd, Stanhope, Catherine, Naughton, Katherine A, Rosasco, Mario G, Bacharier, Leonard B, Gold, Diane R, Hartert, Tina, Khurana Hershey, Gurjit K, Hogarth, D Kyle, Jackson, Daniel J, Johnson, Christine C, Lemanske, Robert F, Lynch, Susan V, Mendonca, Eneida A, Miller, Rachel L, Naureckas, Edward T, O'Connor, George T, Seroogy, Christine M, White, Steven R, Wood, Robert A, Wright, Anne L, Zoratti, Edward M, Martinez, Fernando D, Nicolae, Dan L, Levin, Albert M, and Gern, James E

Published
2020
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13. Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution

Author

Somineni, Hari K, Zhang, Xue, Myers, Jocelyn M Biagini, Kovacic, Melinda Butsch, Ulm, Ashley, Jurcak, Noelle, Ryan, Patrick H, Hershey, Gurjit K Khurana, and Ji, Hong

Subjects
Biomedical and Clinical Sciences, Immunology, Lung, Genetics, Climate-Related Exposures and Conditions, Clinical Research, Pediatric, Asthma, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Respiratory, 5-Methylcytosine, Adolescent, Air Pollution, Alleles, Case-Control Studies, Child, CpG Islands, Cytosine, DNA Methylation, DNA-Binding Proteins, Epigenesis, Genetic, Epithelial Cells, Female, Gene Expression, Humans, Male, Mixed Function Oxygenases, Nasal Mucosa, Promoter Regions, Genetic, Proto-Oncogene Proteins, RNA, Messenger, Risk Factors, Vehicle Emissions, DNA methylation, TET1, 5-hmC, nasal epithelial cells, cross-tissue marker, traffic-related air pollution, asthma, Allergy
Abstract

BackgroundAsthma is a complex disorder influenced by genetics and the environment. Recent findings have linked abnormal DNA methylation in T cells with asthma; however, the potential dysregulation of methylation in airway epithelial cells is unknown. Studies of mouse models of asthma have observed greater levels of 5-hydroxymethylcytosine (5-hmC) and ten-eleven translocation 1 (TET1) expression in lungs. TET proteins are known to catalyze methylation through modification of 5-methylcytosine to 5-hmC.ObjectiveWe sought to examine the association of TET1 methylation with asthma and traffic-related air pollution (TRAP).MethodsTET1 methylation levels from DNA derived from nasal airway epithelial cells collected from 12 African American children with physician-diagnosed asthma and their nonasthmatic siblings were measured by using Illumina 450K arrays. Regions of interest were verified by means of locus-specific pyrosequencing in 35 sibling pairs and replicated in an independent population (n = 186). Exposure to TRAP in participants' early life and at current home addresses was estimated by using a land-use regression model. Methylation studies in saliva, PBMCs, and human bronchial epithelial cells were done to support our findings.ResultsLoss of methylation at a single CpG site in the TET1 promoter (cg23602092) and increased global 5-hmC levels were significantly associated with asthma. In contrast, TRAP exposure at participants' current homes significantly increased methylation at the same site. Patterns were consistent across tissue sample types. 5-Aza-2'-deoxycytidine and diesel exhaust particle exposure in human bronchial epithelial cells was associated with altered TET1 methylation and expression and global 5-hmC levels.ConclusionsOur findings suggest a possible role of TET1 methylation in asthmatic patients and response to TRAP.

Published
2016

16. Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

Author

Miller, Rachel L., primary, Schuh, Holly, additional, Chandran, Aruna, additional, Aris, Izzuddin M., additional, Bendixsen, Casper, additional, Blossom, Jeffrey, additional, Breton, Carrie, additional, Camargo, Carlos A., additional, Canino, Glorisa, additional, Carroll, Kecia N., additional, Commodore, Sarah, additional, Cordero, José F., additional, Dabelea, Dana M., additional, Ferrara, Assiamira, additional, Fry, Rebecca C., additional, Ganiban, Jody M., additional, Gern, James E., additional, Gilliland, Frank D., additional, Gold, Diane R., additional, Habre, Rima, additional, Hare, Marion E., additional, Harte, Robyn N., additional, Hartert, Tina, additional, Hasegawa, Kohei, additional, Khurana Hershey, Gurjit K., additional, Jackson, Daniel J., additional, Joseph, Christine, additional, Kerver, Jean M., additional, Kim, Haejin, additional, Litonjua, Augusto A., additional, Marsit, Carmen J., additional, McEvoy, Cindy, additional, Mendonça, Eneida A., additional, Moore, Paul E., additional, Nkoy, Flory L., additional, O’Connor, Thomas G., additional, Oken, Emily, additional, Ownby, Dennis, additional, Perzanowski, Matthew, additional, Rivera-Spoljaric, Katherine, additional, Ryan, Patrick H., additional, Singh, Anne Marie, additional, Stanford, Joseph B., additional, Wright, Rosalind J., additional, Wright, Robert O., additional, Zanobetti, Antonella, additional, Zoratti, Edward, additional, Johnson, Christine C., additional, Smith, P.B., additional, Newby, K.L., additional, Jacobson, L.P., additional, Catellier, D.J., additional, Gershon, R., additional, Cella, D., additional, Alshawabkeh, A., additional, Aschner, J., additional, Merhar, S., additional, Ren, C., additional, Reynolds, A., additional, Keller, R., additional, Pryhuber, G., additional, Duncan, A., additional, Lampland, A., additional, Wadhawan, R., additional, Wagner, C., additional, Hudak, M., additional, Mayock, D., additional, Walshburn, L., additional, Teitelbaum, S.L., additional, Stroustrup, A., additional, Trasande, L., additional, Blair, C., additional, Gatzke-Kopp, L., additional, Swingler, M., additional, Mansbach, J., additional, Spergel, J., additional, Puls, H., additional, Stevenson, M., additional, Bauer, C., additional, Deoni, S., additional, Duarte, C., additional, Dunlop, A., additional, Elliott, A., additional, Croen, L., additional, Bacharier, L., additional, O’Connor, G., additional, Kattan, M., additional, Wood, R., additional, Hershey, G., additional, Ownby, D., additional, Hertz-Picciotto, I., additional, Hipwell, A., additional, Karagas, M., additional, Karr, C., additional, Mason, A., additional, Sathyanarayana, S., additional, Lester, B., additional, Carter, B., additional, Neal, C., additional, Smith, L., additional, Helderman, J., additional, Leve, L., additional, Ganiban, J., additional, Neiderhiser, J., additional, Weiss, S., additional, Zeiger, R., additional, Tepper, R., additional, Lyall, K., additional, Landa, R., additional, Ozonoff, S., additional, Schmidt, R., additional, Dager, S., additional, Schultz, R., additional, Piven, J., additional, Volk, H., additional, Vaidya, R., additional, Obeid, R., additional, Rollins, C., additional, Bear, K., additional, Pastyrnak, S., additional, Lenski, M., additional, Msall, M., additional, Frazier, J., additional, Washburn, L., additional, Montgomery, A., additional, Barone, C., additional, McKane, P., additional, Paneth, N., additional, Elliott, M., additional, Herbstman, J., additional, Schantz, S., additional, Porucznik, C., additional, Silver, R., additional, Conradt, E., additional, Bosquet-Enlow, M., additional, Huddleston, K., additional, Bush, N., additional, Nguyen, R., additional, O'Connor, T., additional, and Samuels-Kalow, M., additional

Published
2023
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30. Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop

Author

Bousquet, Jean, Gern, James E., Martinez, Fernando D., Anto, Josep M., Johnson, Christine C., Holt, Patrick G., Lemanske, Robert F., Jr., Le Souëf, Peter N., Tepper, Robert S., von Mutius, Erika R.M., Arshad, S. Hasan, Bacharier, Leonard B., Becker, Allan, Belanger, Kathleen, Bergström, Anna, Bernstein, David I., Cabana, Michael D., Carroll, Kecia N., Castro, Mario, Cooper, Philip J., Gillman, Matthew W., Gold, Diane R., Henderson, John, Heinrich, Joachim, Hong, Soo-Jong, Jackson, Daniel J., Keil, Thomas, Kozyrskyj, Anita L., Lødrup Carlsen, Karin C., Miller, Rachel L., Momas, Isabelle, Morgan, Wayne J., Noel, Patricia, Ownby, Dennis R., Pinart, Mariona, Ryan, Patrick H., Schwaninger, Julie M., Sears, Malcolm R., Simpson, Angela, Smit, Henriette A., Stern, Debra A., Subbarao, Padmaja, Valenta, Rudolf, Wang, Xiaobin, Weiss, Scott T., Wood, Robert, Wright, Anne L., Wright, Rosalind J., Togias, Alkis, and Gergen, Peter J.

Published
2014
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43. Additional file 2 of Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study

Author

Hartley, Kim, Ryan, Patrick H., Gillespie, Gordon L., Perazzo, Joseph, Wright, J. Michael, Rice, Glenn E., Donovan, Geoffrey H., Gernes, Rebecca, Hershey, Gurjit K. Khurana, LeMasters, Grace, and Brokamp, Cole

Subjects
urogenital system, lipids (amino acids, peptides, and proteins)
Abstract

Additional file 2: Supplemental Figure 1. Directed acyclic graph (DAG) of child respiratory health and greenness.

Published
2022
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44. Additional file 1 of Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study

Author

Hartley, Kim, Ryan, Patrick H., Gillespie, Gordon L., Perazzo, Joseph, Wright, J. Michael, Rice, Glenn E., Donovan, Geoffrey H., Gernes, Rebecca, Hershey, Gurjit K. Khurana, LeMasters, Grace, and Brokamp, Cole

Subjects
respiratory system, circulatory and respiratory physiology, respiratory tract diseases
Abstract

Additional file 1: Supplemental Table 1. Analysis of Lung Function (percent predicted FEV1, percent predicted FVC, percent predicted FEV1/FVC) and NDVI.

Published
2022
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49. Impact of Personal, Subhourly Exposure to Ultrafine Particles on Respiratory Health in Adolescents with Asthma.

Author

Turner, Ashley L., Brokamp, Cole, Wolfe, Chris, Reponen, Tiina, and Ryan, Patrick H.

Subjects
AIR pollution, PARTICULATE matter, ASTHMA, SOCIAL networks, PSYCHOLOGICAL tests, FORCED expiratory volume, IMPACT of Event Scale, QUESTIONNAIRES, RESEARCH funding, SPIROMETRY
Abstract

Rationale: Ultrafine particle (UFP; particles <0.1 μm in diameter) concentrations exhibit high spatiotemporal variability; thus, individual-level exposures and health risks are difficult to estimate. Objectives: To determine the effects of recent UFP exposures on respiratory health outcomes in children and to determine if children with asthma are at increased risk. Methods: Personal sampling of UFPs was completed by adolescents in combination with repeated personal spirometry measurements and ecological momentary assessment of respiratory symptoms (wheeze, cough, and/or shortness of breath). We assessed the association between UFP exposures every 30 minutes up to 150 minutes before measuring forced expiratory volume in 1 second (FEV1), peak expiratory flow, and respiratory symptoms using mixed-effects models and interaction with asthma diagnosis. Results: Participants (N = 105; 43% with asthma) completed an average of 11 spirometry measurements and 16 symptom responses throughout sampling. After adjustments (maternal education, physical activity, season, and distance to nearest roadway), a 10-fold increase in UFP exposure was significantly associated with a 0.04-L decrease (95% confidence interval [CI], -0.07 to -0.001) in FEV1 90 minutes later. Asthma status modified this association in which participants with asthma had significantly lower FEV1 values in response to UFP exposures 30 minutes earlier than participants without asthma. We found a significant increase in the odds of reporting a respiratory symptom 30 minutes after increased UFP exposure (odds ratio, 1.8; 95% CI, 1.00 to 3.00). Conclusions: Greater UFP exposure conferred deleterious effects on lung function and respiratory symptoms within 90 minutes of exposure and was more pronounced among participants with asthma. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Childhood Asthma Incidence, Early and Persistent Wheeze, and Neighborhood Socioeconomic Factors in the ECHO/CREW Consortium.

Author

Zanobetti, Antonella, Ryan, Patrick H., Coull, Brent, Brokamp, Cole, Datta, Soma, Blossom, Jeffrey, Lothrop, Nathan, Miller, Rachel L., Beamer, Paloma I., Visness, Cynthia M., Andrews, Howard, Bacharier, Leonard B., Hartert, Tina, Johnson, Christine C., Ownby, Dennis, Khurana Hershey, Gurjit K., Joseph, Christine, Yiqiang, Song, Mendonça, Eneida A., and Jackson, Daniel J.

Published
2022
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