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1,323 results on '"Ryan, Kevin M."'

1. Enhanced Quasiparticle Relaxation in a Superconductor via the Proximity Effect

Author

Ryan, Kevin M. and Chandrasekhar, Venkat

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Mesoscale and Nanoscale Physics, Quantum Physics
Abstract

Quasiparticle relaxation in pure superconductors is thought to be determined by the intrinsic inelastic scattering rate in the material. In certain applications, i.e. superconducting qubits and circuits, excess quasiparticles exist at densities far beyond the thermal equilibrium level, potentially leading to dephasing and energy loss. In order to engineer superconductors with shorter overall quasiparticle lifetimes, we consider the impact of a proximity layer on the transport of quasiparticles in a superconductor. We find that a normal metal layer can be used to significantly increase the relaxation rate of quasiparticles in a superconductor, as seen by a large reduction in the quasiparticle charge imbalance in a fully proximitized Cu/Al bilayer wire. The mechanism for this effect may be useful for preventing quasiparticle poisoning of qubits using carefully chosen proximity bilayers consisting of clean superconductors and disordered normal metals., Comment: 8 pages, 6 figures

Published
2024

5. Autophagy and autophagy-related pathways in cancer.

Author

Debnath, Jayanta, Gammoh, Noor, and Ryan, Kevin M

Subjects
Humans, Neoplasms, Autophagy, Lysosomes, Tumor Microenvironment, Cancer, Aetiology, 2.1 Biological and endogenous factors, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Maintenance of protein homeostasis and organelle integrity and function is critical for cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates the delivery of various cellular cargoes to lysosomes for degradation and recycling. A myriad of studies demonstrate important protective roles for autophagy against disease. However, in cancer, seemingly opposing roles of autophagy are observed in the prevention of early tumour development versus the maintenance and metabolic adaptation of established and metastasizing tumours. Recent studies have addressed not only the tumour cell intrinsic functions of autophagy, but also the roles of autophagy in the tumour microenvironment and associated immune cells. In addition, various autophagy-related pathways have been described, which are distinct from classical autophagy, that utilize parts of the autophagic machinery and can potentially contribute to malignant disease. Growing evidence on how autophagy and related processes affect cancer development and progression has helped guide efforts to design anticancer treatments based on inhibition or promotion of autophagy. In this Review, we discuss and dissect these different functions of autophagy and autophagy-related processes during tumour development, maintenance and progression. We outline recent findings regarding the role of these processes in both the tumour cells and the tumour microenvironment and describe advances in therapy aimed at autophagy processes in cancer.

Published
2023

7. Characterization of Nb films for superconducting qubits using phase boundary measurements

Author

Ryan, Kevin M., Torres-Castanedo, Carlos G., Goronzy, Dominic P., Wetter, David A. Garcia, Reagor, Matthew J, Field, Mark, Kopas, Cameron J, Marshall, Jayss, Bedzyk, Michael J., Hersam, Mark C., and Chandrasekhar, Venkat

Subjects
Condensed Matter - Superconductivity
Abstract

Continued advances in superconducting qubit performance require more detailed understandings of the many sources of decoherence. Within these devices, two-level systems arise due to defects, interfaces, and grain boundaries, and are thought to be a major source of qubit decoherence at millikelvin temperatures. In addition to Al, Nb is a commonly used metalization layer for superconducting qubits. Consequently, a significant effort is required to develop and qualify processes that mitigate defects in Nb films. As the fabrication of complete superconducting qubits and their characterization at millikelvin temperatures is a time and resource intensive process, it is desirable to have measurement tools that can rapidly characterize the properties of films and evaluate different treatments. Here we show that measurements of the variation of the superconducting critical temperature $T_c$ with an applied external magnetic field $H$ (of the phase boundary $T_c - H$) performed with very high resolution show features that are directly correlated with the structure of the Nb films. In combination with x-ray diffraction measurements, we show that one can even distinguish variations quality and crystal orientation of the grains in a Nb film by small but reproducible changes in the measured superconducting phase boundary.

Published
2022
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9. Contributors

Author

Adams, Axel, primary, Affun-Adegbulu, Clara, additional, Al-Rasheed, Rakan S., additional, Alaska, Yasser A., additional, Aldawas, Abdulaziz D., additional, Alesa, Saleh Ali, additional, Alexander, George A., additional, Alhadhira, Abdullah Ahmed, additional, Alhajjaj, Fahad Saleha, additional, Alhazmi, Hazem H., additional, Alhussaini, Zainab Abdullah, additional, Aljerian, Nawfal, additional, Aljohani, Majed, additional, AlKhaldi, Khaldoon H., additional, Alkhattabi, Eyad, additional, Allen, Bryant, additional, Almand, Austin, additional, Alnoaimi, Moza M., additional, Alotaibi, Mohammad, additional, Alpert, Evan Avraham, additional, Alrusayni, Yasir A., additional, Alshammari, Mai, additional, Alsulimani, Loui K., additional, Amanullah, Siraj, additional, Anderson, Arian, additional, Arastehmanesh, David, additional, Ardalan, Ali, additional, Argote-Araméndiz, Killiam A., additional, Artenstein, Andrew W., additional, Bailey, Olivia E., additional, Baker, Russell, additional, Balsari, Satchit, additional, Banner, Gregory T., additional, M, Fermin Barrueto, additional, Bartels, Susan A., additional, Baugh, Joshua J., additional, Berg, Frederic, additional, Bhola, Vijai, additional, Binder, William, additional, Bortolin, Michelangelo, additional, Bounes, Vincent, additional, Bouton, Michael, additional, Brown, Natasha, additional, Jr, Frederick M. Burkle,, additional, Burnett, Lynn Barkley, additional, Burns, Michele M., additional, Sr, Nicholas V. Cagliuso,, additional, Cahill, John, additional, Callaway, David W., additional, Caneva, Duane C., additional, Cattamanchi, Srihari, additional, Caycedo, Alejandra, additional, Cetaruk, Edward W., additional, Chacko, Sneha, additional, Chang, James C., additional, Chiang, Crystal, additional, Chiu, David T., additional, Ciottone, Gregory R., additional, Ciottone, Jonathan Peter, additional, Ciottone, Melissa A., additional, Ciottone, Robert A., additional, Ciottone, Robert G., additional, Ciottone, Vigen G., additional, Clark, Alexander, additional, Clark, Jonathan, additional, Conley, Sean P., additional, Cono, Joanne, additional, Cooper, Arthur, additional, Cormier, Scott B., additional, Court, Michael F., additional, Cunningham, Cord W., additional, Czarnecki, Fabrice, additional, Davis, Supriya, additional, Davis, Timothy E., additional, DeMers, Gerard, additional, Dilling, Sharon, additional, Djalali, Ahmadreza, additional, Donahoe, Timothy, additional, Donahue, Joseph, additional, Dresser, Caleb, additional, Dylik, Jason, additional, Easter, Benjamin, additional, Eastman, Alexander, additional, Ebbeling, Laura, additional, Emetarom, Chigozie, additional, Eyal, Nir, additional, Eyre, Andrew J., additional, Freeman, David J., additional, Friedman, Franklin D., additional, Fritz, Christie, additional, Fung, Frederick, additional, Gallahue, Fiona E., additional, Garbern, Stephanie Chow, additional, Gebhart, Mark E., additional, Gluckman, William A., additional, Goolsby, Craig, additional, Gougelet, Robert M., additional, Granholm, Fredrik, additional, Greenough, P. Gregg, additional, Grimes, Jennifer O., additional, Grosse, Steve, additional, Grossman, Shamai A., additional, Jr, John T. Groves, additional, Guidotti, Tee L., additional, Guo, George, additional, Haessler, Sarah, additional, Hall, Matthew M., additional, Hardin, John W., additional, Harrell, Mason, additional, Hart, MD, Alexander, additional, Harvey, Melissa, additional, Hertelendy, PhD, Attila J., additional, Hiremath, Nishanth S., additional, Hitchens, Jordan, additional, Holstege, Christopher P., additional, Horne, Simon T., additional, Horng, Steven, additional, Hosin, Amer, additional, House, Hans R., additional, Ingrassia, Pier Luigi, additional, Issa, Fadi S., additional, Jacoby, Irving “Jake”, additional, Jaiswal, Rajnish, additional, Jay, Gregory, additional, Jenkins, J. Lee, additional, Joseph, Josh W., additional, Kappler, Shane, additional, Keim, Mark E., additional, Kelman, Julie, additional, Ketterer, Andrew R., additional, Khan, Anas A., additional, Kharel, Ramu, additional, Kharod, Chetan U., additional, Kirsch, Thomas D., additional, Knopov, Anita, additional, Kravitz, Max, additional, Lee, J. Austin, additional, Lemery, Jay, additional, Leventhal, Evan L., additional, Loughlin, Jesse, additional, Ludy, Stephanie, additional, Maguire, Brian J., additional, Mahon, Selwyn E., additional, Maniscalco, Paul M., additional, Manners, Philip, additional, Marcus, Leonard Jay, additional, Margus, Colton, additional, Masri, Taha M., additional, Matthews, Jeff, additional, McKay, Sean D., additional, McKinney, Zeke J., additional, McLellan, Robert K., additional, McNulty, Eric J., additional, Mehkri, Faroukh, additional, Mehta, Mandana, additional, Mendelsohn, Rebecca A., additional, Merin, Ofer, additional, Milsten, Andrew, additional, Molé, Dale M., additional, Molloy, Michael Sean, additional, Morelli, Ilaria, additional, Mothershead, Jerry L., additional, Mulhern, John, additional, Mullendore, Nicole F., additional, Musisca, Nicholas J., additional, Naganathan, Sonya, additional, Nathanson, Larry A., additional, Nelson, Erica L., additional, Nelson, Lewis S., additional, Newbury, Bradford A., additional, Newbury, Kimberly, additional, O’Neill, Ansley, additional, Obernier, Robert, additional, Olagnero, Jacopo M., additional, Oostrom-Shah, Leonie, additional, Ordun, Catherine Y., additional, Parazynski, Scott, additional, Park, Andrew J., additional, Partridge, Robert, additional, S, Jeffrey, additional, Phillips, James P., additional, Pinter, Emily, additional, IV, David P. Polatty, additional, Popieluszko, Patrick, additional, Porcaro, William, additional, Proano, Lawrence, additional, Pruitt, Peter B., additional, Qureshi, Moiz, additional, Ragazzoni, Luca, additional, Rashid, Murtaza, additional, Rega, Paul Patrick, additional, Reilly, Michael J., additional, Restuccia, Marc C., additional, Rifino, James J., additional, Robben, Paul M., additional, Rosenblatt, Joy L., additional, Ryan, Kevin M., additional, Rybasack-Smith, Heather, additional, Salway, Richard James, additional, Samo, Daniel, additional, Sanchez, Leon D., additional, Sanford, Shawn M., additional, Sarin, Ritu R., additional, Sarma, Deesha, additional, Schacht, Jesse, additional, Schwind, Valarie, additional, Shapiro, Geoffrey L., additional, Sheehan, Joshua, additional, Shreve, Brian, additional, Simonyan, Grigor, additional, Smith, Devin M., additional, MD, E. Reed Smith,, additional, MA, Jack E. Smith,, additional, Smith, Montray, additional, Smulowitz, Peter B., additional, Snyder, Angela M., additional, Solano, Joshua J., additional, Stenson, Bryan A., additional, Stewart, Charles, additional, Stewart, M. Kathleen, additional, Sullivan, Patrick, additional, Supple, Jared S., additional, Tin, Derrick, additional, Valente, Jonathan Harris, additional, Vear, Kathryn M., additional, Vidyalakshmi, P.R., additional, Vilas, Faith, additional, Vilke, Gary M., additional, Villano, Janna H., additional, Voskanyan, Amalia, additional, Watson, C. James, additional, Weber, Nancy, additional, Weiner, Scott G., additional, Weinstein, Brielle, additional, Weinstein, Eric S., additional, Werner, Jordan R., additional, MD, Roy Karl Werner,, additional, Whitledge, James D., additional, Wiener, Sage W., additional, Wiesner, Lauren, additional, Williams, Kenneth A., additional, Wing, Robyn, additional, Wolfe, Richard E., additional, Wong, Wendy Hin-Wing, additional, Woolard, Robert, additional, Wuthisuthimethawee, Prasit, additional, and Youssef, Nadine A., additional

Published
2024
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13. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Published
2023
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18. Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics

Author

Koessinger, Anna L., Cloix, Catherine, Koessinger, Dominik, Heiland, Dieter Henrik, Bock, Florian J., Strathdee, Karen, Kinch, Kevin, Martínez-Escardó, Laura, Paul, Nikki R., Nixon, Colin, Malviya, Gaurav, Jackson, Mark R., Campbell, Kirsteen J., Stevenson, Katrina, Davis, Sandeep, Elmasry, Yassmin, Ahmed, Asma, O’Prey, Jim, Ichim, Gabriel, Schnell, Oliver, Stewart, William, Blyth, Karen, Ryan, Kevin M., Chalmers, Anthony J., Norman, Jim C., and Tait, Stephen W. G.

Published
2022
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22. Improved Compatibility of α‐NaMnO2 Cathodes at the Interface with Ionic Liquid Electrolytes.

Author

Maresca, Giovanna, Ottaviani, Michela, Ryan, Kevin M., Brutti, Sergio, and Appetecchi, Giovanni B.

Subjects
SOLID electrolytes, IMPEDANCE spectroscopy, CYCLIC voltammetry, SURFACE morphology, IONIC liquids
Abstract

The behaviour and compatibility of monoclinic sodium manganite, α‐NaMnO2, cathodes at the interface with electrolytes based on the 1‐ethyl‐3‐methylimidazolium bis(fluorosulfonyl)imide (EMIFSI) and N‐trimethyl‐N‐butylammonium bis(fluorosulfonyl)imide (N1114FSI) ionic liquids is presented and discussed. The Na+ insertion process was analysed through cyclic voltammetry tests combined with impedance spectroscopy measurements and the cell performance was tested by charge‐discharge cycles. XPS and FIB‐SEM measurements allowed analysis of the surface composition and the morphology of post‐mortem cathodes. Overall, the α‐NaMnO2 cathode showed high reversibility in N1114FSI‐based electrolyte, delivering 60 % of the initial capacity after 1200 cycles in conjunction with a Coulombic efficiency above 99 %. To our knowledge, these very promising results are the best result obtained till now for monolithic α‐NaMnO2 cathodes, are ascribable to the formation of a stable passive layer onto the electrode surface, as confirmed by spectroscopic analysis. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Molecular definitions of autophagy and related processes

Author

Galluzzi, Lorenzo, Baehrecke, Eric H, Ballabio, Andrea, Boya, Patricia, Pedro, José Manuel Bravo‐San, Cecconi, Francesco, Choi, Augustine M, Chu, Charleen T, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Debnath, Jayanta, Deretic, Vojo, Dikic, Ivan, Eskelinen, Eeva‐Liisa, Fimia, Gian Maria, Fulda, Simone, Gewirtz, David A, Green, Douglas R, Hansen, Malene, Harper, J Wade, Jäättelä, Marja, Johansen, Terje, Juhasz, Gabor, Kimmelman, Alec C, Kraft, Claudine, Ktistakis, Nicholas T, Kumar, Sharad, Levine, Beth, Lopez‐Otin, Carlos, Madeo, Frank, Martens, Sascha, Martinez, Jennifer, Melendez, Alicia, Mizushima, Noboru, Münz, Christian, Murphy, Leon O, Penninger, Josef M, Piacentini, Mauro, Reggiori, Fulvio, Rubinsztein, David C, Ryan, Kevin M, Santambrogio, Laura, Scorrano, Luca, Simon, Anna Katharina, Simon, Hans‐Uwe, Simonsen, Anne, Tavernarakis, Nektarios, Tooze, Sharon A, Yoshimori, Tamotsu, Yuan, Junying, Yue, Zhenyu, Zhong, Qing, and Kroemer, Guido

Subjects
Animals, Autophagy, Caenorhabditis elegans, Drosophila melanogaster, Gene Regulatory Networks, Mice, Saccharomyces cerevisiae, Terminology as Topic, chaperone-mediated autophagy, LC3-associated phagocytosis, microautophagy, mitophagy, xenophagy, LC3‐associated phagocytosis, chaperone‐mediated autophagy, Biological Sciences, Information and Computing Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

Published
2017

28. The Development of Diphthongs in Vedic Sanskrit

Author

Ryan, Kevin M.

Subjects
Sanskrit language -- Usage, Phonetics -- Methods, Ethnic, cultural, racial issues/studies
Abstract

Old Indie diphthongs underwent a chain shift whereby e and o monophthongized (ai > e) and ai and au shortened, filling the gap (ai > ai). While it is clear that these changes were complete by the end of the Vedic period, it has been unclear when during (or before) that period they occurred. Based on the avoidance of superheavy syllables in metrical cadences, which is corroborated here, I argue that both shifts took place during the compositional period of the Rgveda. That is, they had not yet begun when the oldest material was composed, but were largely complete by later material, including book 10., In Old Indie metrics, syllable weight is conventionally treated as a binary opposition between heavy (guru) and light (laghu). Nevertheless, as Hoenigswald (1989) and Kobayashi (2001: 94-96) observe, the Rgvedic [...]

Published
2021

29. Structure‐Property Correlations in CZTSe Domains within Semiconductor Nanocrystals as Photovoltaic Absorbers.

Author

Ngoipala, Apinya, Ren, Huan, Ryan, Kevin M., and Vandichel, Matthias

Subjects
SEMICONDUCTOR nanocrystals, HETEROJUNCTIONS, SEMICONDUCTOR junctions, BAND gaps, OPTICAL materials, ABSORPTION spectra
Abstract

Semiconductor nanocrystals (NCs) are promising materials for various applications. Two of four recently identified CuαZnβSnγSeδ (CZTSe) domains demonstrate metallic character, while the other two exhibit semiconductor character. The presence of both metallic and semiconductor domains in one NC can hugely benefit future applications. In contrast to traditional band gap studies in the NC community, this study emphasizes that NC domain interfaces also affect the electronic properties. Specifically, the measured band gap of a tetrapod‐shaped CZTSe NC is demonstrated to originate from two specific domains (tetragonal I4¯$\bar 4$ and monoclinic P1c1 Cu2ZnSnSe4). The heterojunction between these two semiconductor domains exhibits a staggered type‐II band alignment, facilitating the separation of photogenerated electron‐hole pairs. Interestingly, tetrapod NCs have the potential to be efficient absorber materials with higher capacitance in photovoltaic applications due to the presence of both semiconductor/semiconductor interfaces and metal/semiconductor "Schottky"‐junctions. For the two photo‐absorbing domains, the calculated absorption spectra yield maximum photon‐absorption coefficients of about 105 cm−1 in the visible and UV regions and a theoretical solar power conversion efficiency up to 20.8%. These insights into the structure‐property relationships in CZTSe NCs will guide the design of more efficient advanced optical CZTSe materials for various applications. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Highly Efficient Inverted Light-Emitting Diodes Based on Vertically Aligned CdSe/CdS Nanorod Layers Fabricated by Electrophoretic Deposition

Author

Zhang, Yongliang, primary, Pham, Xuan-Manh, additional, Keating, Thomas, additional, Jia, Na, additional, Mullen, Anthony, additional, Laishram, Devika, additional, Gao, Mei-Yan, additional, Corbett, Brian, additional, Liu, Pai, additional, Sun, Xiao Wei, additional, Soulimane, Tewfik, additional, Silien, Christophe, additional, Ryan, Kevin M., additional, Ma, Zhenhui, additional, and Liu, Ning, additional

Published
2024
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35. BRD4-mediated repression of p53 is a target for combination therapy in AML

Author

Latif, Anne-Louise, Newcombe, Ashley, Li, Sha, Gilroy, Kathryn, Robertson, Neil A., Lei, Xue, Stewart, Helen J. S., Cole, John, Terradas, Maria Terradas, Rishi, Loveena, McGarry, Lynn, McKeeve, Claire, Reid, Claire, Clark, William, Campos, Joana, Kirschner, Kristina, Davis, Andrew, Lopez, Jonathan, Sakamaki, Jun-ichi, Morton, Jennifer P., Ryan, Kevin M., Tait, Stephen W. G., Abraham, Sheela A., Holyoake, Tessa, Higgins, Brian, Huang, Xu, Blyth, Karen, Copland, Mhairi, Chevassut, Timothy J. T., Keeshan, Karen, and Adams, Peter D.

Published
2021
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36. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Associazione Italiana per la Ricerca sul Cancro, Italian Institute for Genomic Medicine, Compagnia di San Paolo, Vitale, Ilio [0000-0002-5918-1841], Pietrocola, Federico [0000-0002-2930-234X], Guilbaud, Emma [0000-0001-5261-1944], Aaronson, Stuart A. [0000-0002-4643-0474], Dieter, Adam [0000-0002-5668-5032], Agostini, Massimiliano [0000-0003-3124-2072], Agostinis, Patrizia [0000-0003-1314-2115], Alnemri, Emad S. [0000-0002-7295-3383], Altucci, Lucia [0000-0002-7312-5387], Amelio, Ivano [0000-0002-9126-5391], Andrews, David W. [0000-0002-9266-7157], Aqeilan, Rami I. [0000-0002-6034-023X], Arama, Eli [0000-0001-5953-0629], Balachandran, Siddharth [0000-0003-2084-1803], Bano, Daniele [0000-0002-9617-5504], Bartek, Jiri [0000-0003-2013-7525], Bazan, Nicolas G. [0000-0002-9243-5444], Bernassola, Francesca [0000-0002-8883-8654], Bertrand, Mathieu J. M. [0000-0001-9000-0626], Bianchi, Marco Emilio [0000-0002-5329-6445], Blander, J. Magarian [0000-0001-9207-1700], Blandino, Giovanni [0000-0002-6970-2241], Blomgren, Klas [0000-0002-0476-7271], Bortner, Carl D. [0000-0002-5444-6628], Bove, Pierluigi [0000-0002-4788-2982], Boya, Patricia [0000-0003-3045-951X], Broz, Petr [0000-0002-2334-7790], Damgaard, Rune Busk [0000-0002-1709-6534], Calin, George A. [0000-0002-7427-0578], Campanella, Michelangelo [0000-0002-6948-4184], Candi, Eleonora [0000-0001-8332-4825], Carbone, Michele [0000-0001-8928-8474], Carmona-Gutierrez, Didac [0000-0001-7548-7771], Cecconi, Francesco [0000-0002-5614-4359], Chen, Guo‑Qiang [0000-0002-7226-1782], Cheng, Emily H. [0000-0002-3595-2648], Chipuk, Jerry E. [0000-0002-1337-842X], Cidlowski, John A. [0000-0003-1420-0516], Ciechanover, Aaron [0000-0001-9184-8944], Ciliberto, Gennaro [0000-0003-2851-8605], Conrad, Marcus [0000-0003-1140-5612], Czabotar, Peter E. [0000-0002-2594-496X], D’Angiolella, Vincenzo [0000-0001-8365-9094], Daugaard, Mads [0000-0001-8383-055X], Dawson, Valina L. 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[0000-0001-7872-0196], Walczak, Henning [0000-0002-6312-4591], Wallach, David [0000-0003-2724-9757], Wang, Ruoning [0000-0001-9798-8032], Weber, Achim [0000-0003-0073-3637], Yamazaki, Takahiro [0000-0002-7420-4394], Zakeri, Zahra [0000-0003-4386-8072], Zawacka-Pankau, Joanna E. [0000-0002-7415-2942], Zhivotovsky, Boris [0000-0002-2238-3482], Piacentini, Mauro [0000-0003-2919-1296], Kroemer, Guido [0000-0002-9334-4405], Galluzzi, Lorenzo [0000-0003-2257-8500 ], Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Dieter, Adam, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco Emilio, Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Bomer, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, T., Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chen, Guo‑Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, B., Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian María, Galassi, Claudia, Ganini, Carlo, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravinchandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strappazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, G, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, A., Villunger, Andreas, Von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Zahra, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibin, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Published
2023

37. Autophagy in malignant transformation and cancer progression

Author

Galluzzi, Lorenzo, Pietrocola, Federico, Bravo-San Pedro, José Manuel, Amaravadi, Ravi K, Baehrecke, Eric H, Cecconi, Francesco, Codogno, Patrice, Debnath, Jayanta, Gewirtz, David A, Karantza, Vassiliki, Kimmelman, Alec, Kumar, Sharad, Levine, Beth, Maiuri, Maria Chiara, Martin, Seamus J, Penninger, Josef, Piacentini, Mauro, Rubinsztein, David C, Simon, Hans-Uwe, Simonsen, Anne, Thorburn, Andrew M, Velasco, Guillermo, Ryan, Kevin M, and Kroemer, Guido

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Brain Disorders, Rare Diseases, Brain Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, Autophagy, Cell Transformation, Neoplastic, Humans, Neoplasms, Tumor Escape, Tumor Suppressor Proteins, adaptive stress responses, Beclin 1, inflammation, KRAS, mitophagy, Biological Sciences, Information and Computing Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.

Published
2015

39. Autophagy in major human diseases

Author

Klionsky, Daniel J, Petroni, Giulia, Amaravadi, Ravi K, Baehrecke, Eric H, Ballabio, Andrea, Boya, Patricia, Bravo‐San Pedro, José Manuel, Cadwell, Ken, Cecconi, Francesco, Choi, Augustine M K, Choi, Mary E, Chu, Charleen T, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Deretic, Vojo, Dikic, Ivan, Elazar, Zvulun, Eskelinen, Eeva‐Liisa, Fimia, Gian Maria, Gewirtz, David A, Green, Douglas R, Hansen, Malene, Jäättelä, Marja, Johansen, Terje, Juhász, Gábor, Karantza, Vassiliki, Kraft, Claudine, Kroemer, Guido, Ktistakis, Nicholas T, Kumar, Sharad, Lopez‐Otin, Carlos, Macleod, Kay F, Madeo, Frank, Martinez, Jennifer, Meléndez, Alicia, Mizushima, Noboru, Münz, Christian, Penninger, Josef M, Perera, Rushika M, Piacentini, Mauro, Reggiori, Fulvio, Rubinsztein, David C, Ryan, Kevin M, Sadoshima, Junichi, Santambrogio, Laura, Scorrano, Luca, Simon, Hans‐Uwe, Simon, Anna Katharina, Simonsen, Anne, Stolz, Alexandra, Tavernarakis, Nektarios, Tooze, Sharon A, Yoshimori, Tamotsu, Yuan, Junying, Yue, Zhenyu, Zhong, Qing, Galluzzi, Lorenzo, and Pietrocola, Federico

Published
2021
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45. Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

Author

Baquero, Pablo, Dawson, Amy, Mukhopadhyay, Arunima, Kuntz, Elodie M., Mitchell, Rebecca, Olivares, Orianne, Ianniciello, Angela, Scott, Mary T., Dunn, Karen, Nicastri, Michael C., Winkler, Jeffrey D., Michie, Alison M., Ryan, Kevin M., Halsey, Christina, Gottlieb, Eyal, Keaney, Erin P., Murphy, Leon O., Amaravadi, Ravi K., Holyoake, Tessa L., and Helgason, G. Vignir

Published
2019
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