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3. Prophylactic maintenance with venetoclax/azacitidine after reduced-intensity conditioning allogeneic transplant for high-risk MDS and AML

Author

Garcia, Jacqueline S., Kim, Haesook T., Murdock, H. Moses, Ansuinelli, Michela, Brock, Jennifer, Cutler, Corey S., Gooptu, Mahasweta, Ho, Vincent T., Koreth, John, Nikiforow, Sarah, Romee, Rizwan, Shapiro, Roman, DeAngelo, Daniel J., Stone, Richard M., Bat-Erdene, Denbaa, Ryan, Jeremy, Contreras, Manuel E., Fell, Geoffrey, Letai, Anthony, Ritz, Jerome, Lindsley, R. Coleman, Soiffer, Robert J., and Antin, Joseph H.

Published
2024
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8. Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

Author

Zhang, Qi, Riley-Gillis, Bridget, Han, Lina, Jia, Yannan, Lodi, Alessia, Zhang, Haijiao, Ganesan, Saravanan, Pan, Rongqing, Konoplev, Sergej N., Sweeney, Shannon R., Ryan, Jeremy A., Jitkova, Yulia, Dunner, Jr, Kenneth, Grosskurth, Shaun E., Vijay, Priyanka, Ghosh, Sujana, Lu, Charles, Ma, Wencai, Kurtz, Stephen, Ruvolo, Vivian R., Ma, Helen, Weng, Connie C., Ramage, Cassandra L., Baran, Natalia, Shi, Ce, Cai, Tianyu, Davis, Richard Eric, Battula, Venkata L., Mi, Yingchang, Wang, Jing, DiNardo, Courtney D., Andreeff, Michael, Tyner, Jeffery W., Schimmer, Aaron, Letai, Anthony, Padua, Rose Ann, Bueso-Ramos, Carlos E., Tiziani, Stefano, Leverson, Joel, Popovic, Relja, and Konopleva, Marina

Published
2022
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9. Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

Author

Zhang, Qi, Riley-Gillis, Bridget, Han, Lina, Jia, Yannan, Lodi, Alessia, Zhang, Haijiao, Ganesan, Saravanan, Pan, Rongqing, Konoplev, Sergej N., Sweeney, Shannon R., Ryan, Jeremy A., Jitkova, Yulia, Dunner, Jr, Kenneth, Grosskurth, Shaun E., Vijay, Priyanka, Ghosh, Sujana, Lu, Charles, Ma, Wencai, Kurtz, Stephen, Ruvolo, Vivian R., Ma, Helen, Weng, Connie C., Ramage, Cassandra L., Baran, Natalia, Shi, Ce, Cai, Tianyu, Davis, Richard Eric, Battula, Venkata L., Mi, Yingchang, Wang, Jing, DiNardo, Courtney D., Andreeff, Michael, Tyner, Jeffery W., Schimmer, Aaron, Letai, Anthony, Padua, Rose Ann, Bueso-Ramos, Carlos E., Tiziani, Stefano, Leverson, Joel, Popovic, Relja, and Konopleva, Marina

Published
2022
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10. Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active

Author

Garcia, Jacqueline S., Kim, Haesook T., Murdock, H. Moses, Cutler, Corey S., Brock, Jennifer, Gooptu, Mahasweta, Ho, Vincent T., Koreth, John, Nikiforow, Sarah, Romee, Rizwan, Shapiro, Roman, Loschi, Fiona, Ryan, Jeremy, Fell, Geoffrey, Karp, Hannah Q., Lucas, Fabienne, Kim, Annette S., Potter, Danielle, Mashaka, Thelma, Stone, Richard M., DeAngelo, Daniel J., Letai, Anthony, Lindsley, R. Coleman, Soiffer, Robert J., and Antin, Joseph H.

Published
2021
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12. Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

Author

Bhatt, Shruti, Pioso, Marissa S., Olesinski, Elyse Anne, Yilma, Binyam, Ryan, Jeremy A., Mashaka, Thelma, Leutz, Buon, Adamia, Sophia, Zhu, Haoling, Kuang, Yanan, Mogili, Abhishek, Louissaint, Abner, Jr., Bohl, Stephan R., Kim, Annette S., Mehta, Anita K., Sanghavi, Sneha, Wang, Youzhen, Morris, Erick, Halilovic, Ensar, Paweletz, Cloud P., Weinstock, David M., Garcia, Jacqueline S., and Letai, Anthony

Published
2020
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13. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.

Author

Sarosiek, Kristopher, Fraser, Cameron, Muthalagu, Nathiya, Bhola, Patrick, Chang, Weiting, McBrayer, Samuel, Cantlon, Adam, Fisch, Sudeshna, Golomb-Mello, Gail, Ryan, Jeremy, Deng, Jing, Jian, Brian, Corbett, Chris, Goldenberg, Marti, Madsen, Joseph, Liao, Ronglih, Walsh, Dominic, Sedivy, John, Murphy, Daniel, Carrasco, Daniel, Robinson, Shenandoah, Moslehi, Javid, and Letai, Anthony

Subjects
apoptosis, c-Myc, cardiotoxicity, cell death regulation, chemosensitivity, neurotoxicity, pediatric cancer, radiosensitivity, side effects of chemotherapy, side effects of radiation therapy, Age Factors, Animals, Apoptosis, Doxorubicin, Humans, Mice, Mitochondria, Neoplasms, Organ Specificity, Proto-Oncogene Proteins c-myc, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein
Abstract

It is not understood why healthy tissues can exhibit varying levels of sensitivity to the same toxic stimuli. Using BH3 profiling, we find that mitochondria of many adult somatic tissues, including brain, heart, and kidneys, are profoundly refractory to pro-apoptotic signaling, leading to cellular resistance to cytotoxic chemotherapies and ionizing radiation. In contrast, mitochondria from these tissues in young mice and humans are primed for apoptosis, predisposing them to undergo cell death in response to genotoxic damage. While expression of the apoptotic protein machinery is nearly absent by adulthood, in young tissues its expression is driven by c-Myc, linking developmental growth to cell death. These differences may explain why pediatric cancer patients have a higher risk of developing treatment-associated toxicities.

Published
2017

14. Figure S11 from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts

Author

Olesinski, Elyse A., primary, Bhatia, Karanpreet Singh, primary, Wang, Chuqi, primary, Pioso, Marissa S., primary, Lin, Xiao Xian, primary, Mamdouh, Ahmed M., primary, Ng, Shu Xuan, primary, Sandhu, Vedant, primary, Jasdanwala, Shaista Shabbir, primary, Yilma, Binyam, primary, Bohl, Stephan, primary, Ryan, Jeremy A., primary, Malani, Disha, primary, Luskin, Marlise R., primary, Kallioniemi, Olli, primary, Porkka, Kimmo, primary, Adamia, Sophia, primary, Chng, Wee Joo, primary, Osato, Motomi, primary, Weinstock, David M., primary, Garcia, Jacqueline S., primary, Letai, Anthony, primary, and Bhatt, Shruti, primary

Published
2024
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15. Data from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts

Author

Olesinski, Elyse A., primary, Bhatia, Karanpreet Singh, primary, Wang, Chuqi, primary, Pioso, Marissa S., primary, Lin, Xiao Xian, primary, Mamdouh, Ahmed M., primary, Ng, Shu Xuan, primary, Sandhu, Vedant, primary, Jasdanwala, Shaista Shabbir, primary, Yilma, Binyam, primary, Bohl, Stephan, primary, Ryan, Jeremy A., primary, Malani, Disha, primary, Luskin, Marlise R., primary, Kallioniemi, Olli, primary, Porkka, Kimmo, primary, Adamia, Sophia, primary, Chng, Wee Joo, primary, Osato, Motomi, primary, Weinstock, David M., primary, Garcia, Jacqueline S., primary, Letai, Anthony, primary, and Bhatt, Shruti, primary

Published
2024
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16. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

Author

Townsend, Elizabeth C, Murakami, Mark A, Christodoulou, Alexandra, Christie, Amanda L, Köster, Johannes, DeSouza, Tiffany A, Morgan, Elizabeth A, Kallgren, Scott P, Liu, Huiyun, Wu, Shuo-Chieh, Plana, Olivia, Montero, Joan, Stevenson, Kristen E, Rao, Prakash, Vadhi, Raga, Andreeff, Michael, Armand, Philippe, Ballen, Karen K, Barzaghi-Rinaudo, Patrizia, Cahill, Sarah, Clark, Rachael A, Cooke, Vesselina G, Davids, Matthew S, DeAngelo, Daniel J, Dorfman, David M, Eaton, Hilary, Ebert, Benjamin L, Etchin, Julia, Firestone, Brant, Fisher, David C, Freedman, Arnold S, Galinsky, Ilene A, Gao, Hui, Garcia, Jacqueline S, Garnache-Ottou, Francine, Graubert, Timothy A, Gutierrez, Alejandro, Halilovic, Ensar, Harris, Marian H, Herbert, Zachary T, Horwitz, Steven M, Inghirami, Giorgio, Intlekofer, Andrew M, Ito, Moriko, Izraeli, Shai, Jacobsen, Eric D, Jacobson, Caron A, Jeay, Sébastien, Jeremias, Irmela, Kelliher, Michelle A, Koch, Raphael, Konopleva, Marina, Kopp, Nadja, Kornblau, Steven M, Kung, Andrew L, Kupper, Thomas S, LeBoeuf, Nicole R, LaCasce, Ann S, Lees, Emma, Li, Loretta S, Look, A Thomas, Murakami, Masato, Muschen, Markus, Neuberg, Donna, Ng, Samuel Y, Odejide, Oreofe O, Orkin, Stuart H, Paquette, Rachel R, Place, Andrew E, Roderick, Justine E, Ryan, Jeremy A, Sallan, Stephen E, Shoji, Brent, Silverman, Lewis B, Soiffer, Robert J, Steensma, David P, Stegmaier, Kimberly, Stone, Richard M, Tamburini, Jerome, Thorner, Aaron R, van Hummelen, Paul, Wadleigh, Martha, Wiesmann, Marion, Weng, Andrew P, Wuerthner, Jens U, Williams, David A, Wollison, Bruce M, Lane, Andrew A, Letai, Anthony, Bertagnolli, Monica M, Ritz, Jerome, Brown, Myles, Long, Henry, Aster, Jon C, Shipp, Margaret A, Griffin, James D, and Weinstock, David M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biotechnology, Clinical Trials and Supportive Activities, Orphan Drug, Clinical Research, Hematology, Cancer, Rare Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Good Health and Well Being, Animals, Antineoplastic Agents, Biomarkers, Tumor, Cell Lineage, Female, Gene Expression Profiling, Genes, p53, Heterografts, Humans, Internet, Isoquinolines, Leukemia, Leukemia, Experimental, Lymphoma, Male, Mice, Mice, Inbred NOD, Molecular Targeted Therapy, Neoplasm Proteins, Neoplasm Transplantation, Phenotype, Piperazines, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Proteome, Proto-Oncogene Proteins c-mdm2, Random Allocation, Randomized Controlled Trials as Topic, Research Design, Tissue Banks, Transcriptome, Xenograft Model Antitumor Assays, Neurosciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease.

Published
2016

23. MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

Author

Dammert, Marcel A., Brägelmann, Johannes, Olsen, Rachelle R., Böhm, Stefanie, Monhasery, Niloufar, Whitney, Christopher P., Chalishazar, Milind D., Tumbrink, Hannah L., Guthrie, Matthew R., Klein, Sebastian, Ireland, Abbie S., Ryan, Jeremy, Schmitt, Anna, Marx, Annika, Ozretić, Luka, Castiglione, Roberta, Lorenz, Carina, Jachimowicz, Ron D., Wolf, Elmar, Thomas, Roman K., Poirier, John T., Büttner, Reinhard, Sen, Triparna, Byers, Lauren A., Reinhardt, H. Christian, Letai, Anthony, Oliver, Trudy G., and Sos, Martin L.

Published
2019
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24. Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

Author

Seyfried, Felix, Demir, Salih, Hörl, Rebecca Louise, Stirnweiß, Felix Uli, Ryan, Jeremy, Scheffold, Annika, Villalobos-Ortiz, Mariana, Boldrin, Elena, Zinngrebe, Julia, Enzenmüller, Stefanie, Jenni, Silvia, Tsai, Yi-Chien, Bornhauser, Beat, Fürstberger, Axel, Kraus, Johann Michael, Kestler, Hans Armin, Bourquin, Jean-Pierre, Stilgenbauer, Stephan, Letai, Anthony, Debatin, Klaus-Michael, and Meyer, Lüder Hinrich

Published
2019
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26. Table S3 from An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

Author

Flümann, Ruth, primary, Rehkämper, Tim, primary, Nieper, Pascal, primary, Pfeiffer, Pauline, primary, Holzem, Alessandra, primary, Klein, Sebastian, primary, Bhatia, Sanil, primary, Kochanek, Moritz, primary, Kisis, Ilmars, primary, Pelzer, Benedikt W., primary, Ahlert, Heinz, primary, Hauer, Julia, primary, da Palma Guerreiro, Alexandra, primary, Ryan, Jeremy A., primary, Reimann, Maurice, primary, Riabinska, Arina, primary, Wiederstein, Janica, primary, Krüger, Marcus, primary, Deckert, Martina, primary, Altmüller, Janine, primary, Klatt, Andreas R., primary, Frenzel, Lukas P., primary, Pasqualucci, Laura, primary, Béguelin, Wendy, primary, Melnick, Ari M., primary, Sander, Sandrine, primary, Montesinos-Rongen, Manuel, primary, Brunn, Anna, primary, Lohneis, Philipp, primary, Büttner, Reinhard, primary, Kashkar, Hamid, primary, Borkhardt, Arndt, primary, Letai, Anthony, primary, Persigehl, Thorsten, primary, Peifer, Martin, primary, Schmitt, Clemens A., primary, Reinhardt, Hans Christian, primary, and Knittel, Gero, primary

Published
2023
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27. Data from An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

Author

Flümann, Ruth, primary, Rehkämper, Tim, primary, Nieper, Pascal, primary, Pfeiffer, Pauline, primary, Holzem, Alessandra, primary, Klein, Sebastian, primary, Bhatia, Sanil, primary, Kochanek, Moritz, primary, Kisis, Ilmars, primary, Pelzer, Benedikt W., primary, Ahlert, Heinz, primary, Hauer, Julia, primary, da Palma Guerreiro, Alexandra, primary, Ryan, Jeremy A., primary, Reimann, Maurice, primary, Riabinska, Arina, primary, Wiederstein, Janica, primary, Krüger, Marcus, primary, Deckert, Martina, primary, Altmüller, Janine, primary, Klatt, Andreas R., primary, Frenzel, Lukas P., primary, Pasqualucci, Laura, primary, Béguelin, Wendy, primary, Melnick, Ari M., primary, Sander, Sandrine, primary, Montesinos-Rongen, Manuel, primary, Brunn, Anna, primary, Lohneis, Philipp, primary, Büttner, Reinhard, primary, Kashkar, Hamid, primary, Borkhardt, Arndt, primary, Letai, Anthony, primary, Persigehl, Thorsten, primary, Peifer, Martin, primary, Schmitt, Clemens A., primary, Reinhardt, Hans Christian, primary, and Knittel, Gero, primary

Published
2023
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28. Supplementary Data from An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

Author

Flümann, Ruth, primary, Rehkämper, Tim, primary, Nieper, Pascal, primary, Pfeiffer, Pauline, primary, Holzem, Alessandra, primary, Klein, Sebastian, primary, Bhatia, Sanil, primary, Kochanek, Moritz, primary, Kisis, Ilmars, primary, Pelzer, Benedikt W., primary, Ahlert, Heinz, primary, Hauer, Julia, primary, da Palma Guerreiro, Alexandra, primary, Ryan, Jeremy A., primary, Reimann, Maurice, primary, Riabinska, Arina, primary, Wiederstein, Janica, primary, Krüger, Marcus, primary, Deckert, Martina, primary, Altmüller, Janine, primary, Klatt, Andreas R., primary, Frenzel, Lukas P., primary, Pasqualucci, Laura, primary, Béguelin, Wendy, primary, Melnick, Ari M., primary, Sander, Sandrine, primary, Montesinos-Rongen, Manuel, primary, Brunn, Anna, primary, Lohneis, Philipp, primary, Büttner, Reinhard, primary, Kashkar, Hamid, primary, Borkhardt, Arndt, primary, Letai, Anthony, primary, Persigehl, Thorsten, primary, Peifer, Martin, primary, Schmitt, Clemens A., primary, Reinhardt, Hans Christian, primary, and Knittel, Gero, primary

Published
2023
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29. Data from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Author

Chonghaile, Triona Ni, primary, Roderick, Justine E., primary, Glenfield, Cian, primary, Ryan, Jeremy, primary, Sallan, Stephen E., primary, Silverman, Lewis B., primary, Loh, Mignon L., primary, Hunger, Stephen P., primary, Wood, Brent, primary, DeAngelo, Daniel J., primary, Stone, Richard, primary, Harris, Marian, primary, Gutierrez, Alejandro, primary, Kelliher, Michelle A., primary, and Letai, Anthony, primary

Published
2023
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30. Supplementary Figure S6 from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Author

Chonghaile, Triona Ni, primary, Roderick, Justine E., primary, Glenfield, Cian, primary, Ryan, Jeremy, primary, Sallan, Stephen E., primary, Silverman, Lewis B., primary, Loh, Mignon L., primary, Hunger, Stephen P., primary, Wood, Brent, primary, DeAngelo, Daniel J., primary, Stone, Richard, primary, Harris, Marian, primary, Gutierrez, Alejandro, primary, Kelliher, Michelle A., primary, and Letai, Anthony, primary

Published
2023
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31. Supplementary Table S4 from Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

Author

Stover, Elizabeth H., primary, Baco, Maria B., primary, Cohen, Ofir, primary, Li, Yvonne Y., primary, Christie, Elizabeth L., primary, Bagul, Mukta, primary, Goodale, Amy, primary, Lee, Yenarae, primary, Pantel, Sasha, primary, Rees, Matthew G., primary, Wei, Guo, primary, Presser, Adam G., primary, Gelbard, Maya K., primary, Zhang, Weiqun, primary, Zervantonakis, Ioannis K., primary, Bhola, Patrick D., primary, Ryan, Jeremy, primary, Guerriero, Jennifer L., primary, Montero, Joan, primary, Liang, Felice J., primary, Cherniack, Andrew D., primary, Piccioni, Federica, primary, Matulonis, Ursula A., primary, Bowtell, David D.L., primary, Sarosiek, Kristopher A., primary, Letai, Anthony, primary, Garraway, Levi A., primary, Johannessen, Cory M., primary, and Meyerson, Matthew, primary

Published
2023
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32. Supplementary Figures from Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

Author

Pan, Rongqing, primary, Hogdal, Leah J., primary, Benito, Juliana M., primary, Bucci, Donna, primary, Han, Lina, primary, Borthakur, Gautam, primary, Cortes, Jorge, primary, DeAngelo, Daniel J., primary, Debose, LaKeisha, primary, Mu, Hong, primary, Döhner, Hartmut, primary, Gaidzik, Verena I., primary, Galinsky, Ilene, primary, Golfman, Leonard S., primary, Haferlach, Torsten, primary, Harutyunyan, Karine G., primary, Hu, Jianhua, primary, Leverson, Joel D., primary, Marcucci, Guido, primary, Müschen, Markus, primary, Newman, Rachel, primary, Park, Eugene, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian, primary, Ryan, Jeremy, primary, Schindela, Sonja, primary, Zweidler-McKay, Patrick, primary, Stone, Richard M., primary, Kantarjian, Hagop, primary, Andreeff, Michael, primary, Konopleva, Marina, primary, and Letai, Anthony G., primary

Published
2023
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33. Data from Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

Author

Pan, Rongqing, primary, Hogdal, Leah J., primary, Benito, Juliana M., primary, Bucci, Donna, primary, Han, Lina, primary, Borthakur, Gautam, primary, Cortes, Jorge, primary, DeAngelo, Daniel J., primary, Debose, LaKeisha, primary, Mu, Hong, primary, Döhner, Hartmut, primary, Gaidzik, Verena I., primary, Galinsky, Ilene, primary, Golfman, Leonard S., primary, Haferlach, Torsten, primary, Harutyunyan, Karine G., primary, Hu, Jianhua, primary, Leverson, Joel D., primary, Marcucci, Guido, primary, Müschen, Markus, primary, Newman, Rachel, primary, Park, Eugene, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian, primary, Ryan, Jeremy, primary, Schindela, Sonja, primary, Zweidler-McKay, Patrick, primary, Stone, Richard M., primary, Kantarjian, Hagop, primary, Andreeff, Michael, primary, Konopleva, Marina, primary, and Letai, Anthony G., primary

Published
2023
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34. Data from Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

Author

Stover, Elizabeth H., primary, Baco, Maria B., primary, Cohen, Ofir, primary, Li, Yvonne Y., primary, Christie, Elizabeth L., primary, Bagul, Mukta, primary, Goodale, Amy, primary, Lee, Yenarae, primary, Pantel, Sasha, primary, Rees, Matthew G., primary, Wei, Guo, primary, Presser, Adam G., primary, Gelbard, Maya K., primary, Zhang, Weiqun, primary, Zervantonakis, Ioannis K., primary, Bhola, Patrick D., primary, Ryan, Jeremy, primary, Guerriero, Jennifer L., primary, Montero, Joan, primary, Liang, Felice J., primary, Cherniack, Andrew D., primary, Piccioni, Federica, primary, Matulonis, Ursula A., primary, Bowtell, David D.L., primary, Sarosiek, Kristopher A., primary, Letai, Anthony, primary, Garraway, Levi A., primary, Johannessen, Cory M., primary, and Meyerson, Matthew, primary

Published
2023
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35. Data from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

Author

Lin, Shan, primary, Larrue, Clément, primary, Scheidegger, Nastassja K., primary, Seong, Bo Kyung A., primary, Dharia, Neekesh V., primary, Kuljanin, Miljan, primary, Wechsler, Caroline S., primary, Kugener, Guillaume, primary, Robichaud, Amanda L., primary, Conway, Amy Saur, primary, Mashaka, Thelma, primary, Mouche, Sarah, primary, Adane, Biniam, primary, Ryan, Jeremy A., primary, Mancias, Joseph D., primary, Younger, Scott T., primary, Piccioni, Federica, primary, Lee, Lynn H., primary, Wunderlich, Mark, primary, Letai, Anthony, primary, Tamburini, Jérôme, primary, and Stegmaier, Kimberly, primary

Published
2023
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36. Supplementary Tables from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

Author

Lin, Shan, primary, Larrue, Clément, primary, Scheidegger, Nastassja K., primary, Seong, Bo Kyung A., primary, Dharia, Neekesh V., primary, Kuljanin, Miljan, primary, Wechsler, Caroline S., primary, Kugener, Guillaume, primary, Robichaud, Amanda L., primary, Conway, Amy Saur, primary, Mashaka, Thelma, primary, Mouche, Sarah, primary, Adane, Biniam, primary, Ryan, Jeremy A., primary, Mancias, Joseph D., primary, Younger, Scott T., primary, Piccioni, Federica, primary, Lee, Lynn H., primary, Wunderlich, Mark, primary, Letai, Anthony, primary, Tamburini, Jérôme, primary, and Stegmaier, Kimberly, primary

Published
2023
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37. Supplementary Data from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

Author

Lin, Shan, primary, Larrue, Clément, primary, Scheidegger, Nastassja K., primary, Seong, Bo Kyung A., primary, Dharia, Neekesh V., primary, Kuljanin, Miljan, primary, Wechsler, Caroline S., primary, Kugener, Guillaume, primary, Robichaud, Amanda L., primary, Conway, Amy Saur, primary, Mashaka, Thelma, primary, Mouche, Sarah, primary, Adane, Biniam, primary, Ryan, Jeremy A., primary, Mancias, Joseph D., primary, Younger, Scott T., primary, Piccioni, Federica, primary, Lee, Lynn H., primary, Wunderlich, Mark, primary, Letai, Anthony, primary, Tamburini, Jérôme, primary, and Stegmaier, Kimberly, primary

Published
2023
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38. Supplementary Table 2 from Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

Author

Pan, Rongqing, primary, Hogdal, Leah J., primary, Benito, Juliana M., primary, Bucci, Donna, primary, Han, Lina, primary, Borthakur, Gautam, primary, Cortes, Jorge, primary, DeAngelo, Daniel J., primary, Debose, LaKeisha, primary, Mu, Hong, primary, Döhner, Hartmut, primary, Gaidzik, Verena I., primary, Galinsky, Ilene, primary, Golfman, Leonard S., primary, Haferlach, Torsten, primary, Harutyunyan, Karine G., primary, Hu, Jianhua, primary, Leverson, Joel D., primary, Marcucci, Guido, primary, Müschen, Markus, primary, Newman, Rachel, primary, Park, Eugene, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian, primary, Ryan, Jeremy, primary, Schindela, Sonja, primary, Zweidler-McKay, Patrick, primary, Stone, Richard M., primary, Kantarjian, Hagop, primary, Andreeff, Michael, primary, Konopleva, Marina, primary, and Letai, Anthony G., primary

Published
2023
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39. Supplementary Methods from Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

Author

Pan, Rongqing, primary, Hogdal, Leah J., primary, Benito, Juliana M., primary, Bucci, Donna, primary, Han, Lina, primary, Borthakur, Gautam, primary, Cortes, Jorge, primary, DeAngelo, Daniel J., primary, Debose, LaKeisha, primary, Mu, Hong, primary, Döhner, Hartmut, primary, Gaidzik, Verena I., primary, Galinsky, Ilene, primary, Golfman, Leonard S., primary, Haferlach, Torsten, primary, Harutyunyan, Karine G., primary, Hu, Jianhua, primary, Leverson, Joel D., primary, Marcucci, Guido, primary, Müschen, Markus, primary, Newman, Rachel, primary, Park, Eugene, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian, primary, Ryan, Jeremy, primary, Schindela, Sonja, primary, Zweidler-McKay, Patrick, primary, Stone, Richard M., primary, Kantarjian, Hagop, primary, Andreeff, Michael, primary, Konopleva, Marina, primary, and Letai, Anthony G., primary

Published
2023
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40. Supplementary figures and supplementary table legends from Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

Author

Stover, Elizabeth H., primary, Baco, Maria B., primary, Cohen, Ofir, primary, Li, Yvonne Y., primary, Christie, Elizabeth L., primary, Bagul, Mukta, primary, Goodale, Amy, primary, Lee, Yenarae, primary, Pantel, Sasha, primary, Rees, Matthew G., primary, Wei, Guo, primary, Presser, Adam G., primary, Gelbard, Maya K., primary, Zhang, Weiqun, primary, Zervantonakis, Ioannis K., primary, Bhola, Patrick D., primary, Ryan, Jeremy, primary, Guerriero, Jennifer L., primary, Montero, Joan, primary, Liang, Felice J., primary, Cherniack, Andrew D., primary, Piccioni, Federica, primary, Matulonis, Ursula A., primary, Bowtell, David D.L., primary, Sarosiek, Kristopher A., primary, Letai, Anthony, primary, Garraway, Levi A., primary, Johannessen, Cory M., primary, and Meyerson, Matthew, primary

Published
2023
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41. Supplementary methods from Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

Author

Stover, Elizabeth H., primary, Baco, Maria B., primary, Cohen, Ofir, primary, Li, Yvonne Y., primary, Christie, Elizabeth L., primary, Bagul, Mukta, primary, Goodale, Amy, primary, Lee, Yenarae, primary, Pantel, Sasha, primary, Rees, Matthew G., primary, Wei, Guo, primary, Presser, Adam G., primary, Gelbard, Maya K., primary, Zhang, Weiqun, primary, Zervantonakis, Ioannis K., primary, Bhola, Patrick D., primary, Ryan, Jeremy, primary, Guerriero, Jennifer L., primary, Montero, Joan, primary, Liang, Felice J., primary, Cherniack, Andrew D., primary, Piccioni, Federica, primary, Matulonis, Ursula A., primary, Bowtell, David D.L., primary, Sarosiek, Kristopher A., primary, Letai, Anthony, primary, Garraway, Levi A., primary, Johannessen, Cory M., primary, and Meyerson, Matthew, primary

Published
2023
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42. Supplementary Figure Legends from Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

Author

Pan, Rongqing, primary, Hogdal, Leah J., primary, Benito, Juliana M., primary, Bucci, Donna, primary, Han, Lina, primary, Borthakur, Gautam, primary, Cortes, Jorge, primary, DeAngelo, Daniel J., primary, Debose, LaKeisha, primary, Mu, Hong, primary, Döhner, Hartmut, primary, Gaidzik, Verena I., primary, Galinsky, Ilene, primary, Golfman, Leonard S., primary, Haferlach, Torsten, primary, Harutyunyan, Karine G., primary, Hu, Jianhua, primary, Leverson, Joel D., primary, Marcucci, Guido, primary, Müschen, Markus, primary, Newman, Rachel, primary, Park, Eugene, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian, primary, Ryan, Jeremy, primary, Schindela, Sonja, primary, Zweidler-McKay, Patrick, primary, Stone, Richard M., primary, Kantarjian, Hagop, primary, Andreeff, Michael, primary, Konopleva, Marina, primary, and Letai, Anthony G., primary

Published
2023
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43. Supplementary Figures from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

Author

Lin, Shan, primary, Larrue, Clément, primary, Scheidegger, Nastassja K., primary, Seong, Bo Kyung A., primary, Dharia, Neekesh V., primary, Kuljanin, Miljan, primary, Wechsler, Caroline S., primary, Kugener, Guillaume, primary, Robichaud, Amanda L., primary, Conway, Amy Saur, primary, Mashaka, Thelma, primary, Mouche, Sarah, primary, Adane, Biniam, primary, Ryan, Jeremy A., primary, Mancias, Joseph D., primary, Younger, Scott T., primary, Piccioni, Federica, primary, Lee, Lynn H., primary, Wunderlich, Mark, primary, Letai, Anthony, primary, Tamburini, Jérôme, primary, and Stegmaier, Kimberly, primary

Published
2023
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44. Supplementary Table 1 from Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

Author

Pan, Rongqing, primary, Hogdal, Leah J., primary, Benito, Juliana M., primary, Bucci, Donna, primary, Han, Lina, primary, Borthakur, Gautam, primary, Cortes, Jorge, primary, DeAngelo, Daniel J., primary, Debose, LaKeisha, primary, Mu, Hong, primary, Döhner, Hartmut, primary, Gaidzik, Verena I., primary, Galinsky, Ilene, primary, Golfman, Leonard S., primary, Haferlach, Torsten, primary, Harutyunyan, Karine G., primary, Hu, Jianhua, primary, Leverson, Joel D., primary, Marcucci, Guido, primary, Müschen, Markus, primary, Newman, Rachel, primary, Park, Eugene, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian, primary, Ryan, Jeremy, primary, Schindela, Sonja, primary, Zweidler-McKay, Patrick, primary, Stone, Richard M., primary, Kantarjian, Hagop, primary, Andreeff, Michael, primary, Konopleva, Marina, primary, and Letai, Anthony G., primary

Published
2023
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45. Supplementary Figures from Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy

Author

Deng, Jing, primary, Paulus, Aneel, primary, Fang, Douglas D., primary, Manna, Alak, primary, Wang, Guangfeng, primary, Wang, Hengbang, primary, Zhu, Saijie, primary, Chen, Jianyong, primary, Min, Ping, primary, Yin, Yan, primary, Dutta, Navnita, primary, Halder, Nabanita, primary, Ciccio, Gina, primary, Copland, John A., primary, Miller, James, primary, Han, Bing, primary, Bai, Longchuan, primary, Liu, Liu, primary, Wang, Mi, primary, McEachern, Donna, primary, Przybranowski, Sally, primary, Yang, Chao-Yie, primary, Stuckey, Jeanne A., primary, Wu, Depei, primary, Li, Caixia, primary, Ryan, Jeremy, primary, Letai, Anthony, primary, Ailawadhi, Sikander, primary, Yang, Dajun, primary, Wang, Shaomeng, primary, Chanan-Khan, Asher, primary, and Zhai, Yifan, primary

Published
2023
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46. Supplementary Tables from Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy

Author

Deng, Jing, primary, Paulus, Aneel, primary, Fang, Douglas D., primary, Manna, Alak, primary, Wang, Guangfeng, primary, Wang, Hengbang, primary, Zhu, Saijie, primary, Chen, Jianyong, primary, Min, Ping, primary, Yin, Yan, primary, Dutta, Navnita, primary, Halder, Nabanita, primary, Ciccio, Gina, primary, Copland, John A., primary, Miller, James, primary, Han, Bing, primary, Bai, Longchuan, primary, Liu, Liu, primary, Wang, Mi, primary, McEachern, Donna, primary, Przybranowski, Sally, primary, Yang, Chao-Yie, primary, Stuckey, Jeanne A., primary, Wu, Depei, primary, Li, Caixia, primary, Ryan, Jeremy, primary, Letai, Anthony, primary, Ailawadhi, Sikander, primary, Yang, Dajun, primary, Wang, Shaomeng, primary, Chanan-Khan, Asher, primary, and Zhai, Yifan, primary

Published
2023
Full Text
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47. Supplementary Data from Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy

Author

Deng, Jing, primary, Paulus, Aneel, primary, Fang, Douglas D., primary, Manna, Alak, primary, Wang, Guangfeng, primary, Wang, Hengbang, primary, Zhu, Saijie, primary, Chen, Jianyong, primary, Min, Ping, primary, Yin, Yan, primary, Dutta, Navnita, primary, Halder, Nabanita, primary, Ciccio, Gina, primary, Copland, John A., primary, Miller, James, primary, Han, Bing, primary, Bai, Longchuan, primary, Liu, Liu, primary, Wang, Mi, primary, McEachern, Donna, primary, Przybranowski, Sally, primary, Yang, Chao-Yie, primary, Stuckey, Jeanne A., primary, Wu, Depei, primary, Li, Caixia, primary, Ryan, Jeremy, primary, Letai, Anthony, primary, Ailawadhi, Sikander, primary, Yang, Dajun, primary, Wang, Shaomeng, primary, Chanan-Khan, Asher, primary, and Zhai, Yifan, primary

Published
2023
Full Text
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48. Data from BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death

Author

Dutta, Chaitali, primary, Day, Tovah, primary, Kopp, Nadja, primary, van Bodegom, Diederik, primary, Davids, Matthew S., primary, Ryan, Jeremy, primary, Bird, Liat, primary, Kommajosyula, Naveen, primary, Weigert, Oliver, primary, Yoda, Akinori, primary, Fung, Hua, primary, Brown, Jennifer R., primary, Shapiro, Geoffrey I., primary, Letai, Anthony, primary, and Weinstock, David M., primary

Published
2023
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49. Supplementary Methods, Figures 1-3 from BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death

Author

Dutta, Chaitali, primary, Day, Tovah, primary, Kopp, Nadja, primary, van Bodegom, Diederik, primary, Davids, Matthew S., primary, Ryan, Jeremy, primary, Bird, Liat, primary, Kommajosyula, Naveen, primary, Weigert, Oliver, primary, Yoda, Akinori, primary, Fung, Hua, primary, Brown, Jennifer R., primary, Shapiro, Geoffrey I., primary, Letai, Anthony, primary, and Weinstock, David M., primary

Published
2023
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50. Supplementary Table 2 from BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death

Author

Dutta, Chaitali, primary, Day, Tovah, primary, Kopp, Nadja, primary, van Bodegom, Diederik, primary, Davids, Matthew S., primary, Ryan, Jeremy, primary, Bird, Liat, primary, Kommajosyula, Naveen, primary, Weigert, Oliver, primary, Yoda, Akinori, primary, Fung, Hua, primary, Brown, Jennifer R., primary, Shapiro, Geoffrey I., primary, Letai, Anthony, primary, and Weinstock, David M., primary

Published
2023
Full Text
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